Last Section 2007

Awards, Education, Centers and Institutes, and Organizations

A thick quartz section was photographed by using interference

cross-polarization photomicrography. The photomicrograph was

captured at 20x magnification, with a digital Nikon D100 single

lens reflex camera back, with the ISO rated at 200. The image was

created to demonstrate how most colorless, translucent specimens

(e.g., bone tissue, crystals), can be transformed to an image replete

with a full-color spectrum. The resulting images have pseudo-hues

that help delineate fine structures and details that might other-

wise have gone unnoticed. The image was created by Bob Turner,

director, BioMedical Graphics, as an example of this technique

for Scripps Research investigators to consider usng when illustrating

their science. The photomicrograph received honorable mention in

the 2007 Nikon Small World Photomicrography Competition.

Class of 2007

Kellogg School of Science and Technology

Staff Awards and Activities

Barbas, C.F. IIIFellow, American Association for theAdvancement of Science; In-Cites Highly CitedResearcher, Thomson Scientific, Philadelphia, Pennsyl-vania; Member, Faculty in Chemical Biology, Faculty1000, Biology Reports, Ltd.; Editorial Boards, Bioor-ganic and Medicinal Chemistry Letters, Bioorganicand Medicinal Chemistry.

Beutler, B.William B. Coley Award for DistinguishedResearch in Basic and Tumor Immunology, CancerResearch Institute; Gran Prix Charles-Leopold-Mayer,Grand Prize, French Academy of Sciences; Doctor ofMedicine Honoris Causa, Technical University of Munich,Munich, Germany.

Boger, D.L.ACS Ernest Guenther Award in NaturalProducts Chemistry, American Chemical Society; Fel-low, American Academy of Arts and Sciences; OlsenLecturer, Utah State University, Logan, Utah; Editor-in-Chief, Bioorganic and Medicinal Chemistry Letters;Editorial Boards, Tetrahedron Publications, OrganicReactions, Current Opinion in Drug Discovery andDevelopment, Current Drugs.

Bokoch, G.M.Editorial Boards, Journal of LeukocyteBiology, Journal of Biological Chemistry, MolecularPharmacology.

Brooks, C.L. IIIEditor-in-Chief, Journal of Computa-tional Chemistry.

Buchmeier, M.J.Fellow, American Academy of Micro-biology; Fellow, American Association for the Advance-ment of Science; Associate Director, Pacific SouthwestCenter for Biodefense and Emerging Infectious Diseases;Chair, American Society for Microbiology 6th AnnualBiodefense and Emerging Diseases Research Meeting;Member, Scientific Advisory Boards, Biodefense andEmerging Infections Research Resources Repository,PathoSystems Resource Integration Center (VirginiaBioInformatics Institute), Predictive Biology Initiative,Pacific Northwest National Laboratories; Member,National Multiple Sclerosis Society Study Section; Editor, Microbiology and Molecular Biology Reviews;Associate Editor, Journal of Virology, PloS Pathogens,Virology, Viral Immunology, BMC Microbiology, Virol-ogy Journal.

Case, D.A.Associate Editor, Biopolymers, Journal ofMolecular Biology; Editorial Board, Journal of Biomol-ecular NMR.

Chisari, F.V.Distinguished Scientist Award, Hepatitis

B Foundation; Fellow, American Academy of Microbi-

ology; Member, National Academy of Sciences; Member,

Institute of Medicine, National Academy of Sciences;

Member, Class IV Membership Committee, National

Academy of Sciences; Member, Scientific Advisory

Board, Center for the Study of HCV, Rockefeller Uni-

versity, New York, New York; Member, Scientific Advi-

sory Board, Northeast Biodefense Center; ISI Highly

Cited Researcher; Stone Memorial Lecture, Pennsylva-

nia State University, University Park, Pennsylvania;

Editorial Boards, Journal of Virology, Viral Immunol-

ogy, Virology, Microbial Pathogenesis, Journal of Clini-

cal Investigation.

Cleveland, J.L.Editor, Molecular and Cellular Biology;Senior Editor, Molecular Cancer Research; AssociateEditor, Molecular Biology of the Cell, Cell Death andDifferentiation.

Curtiss, L.K.Distinguished Achievement Award, Amer-ican Heart Association; Fellow, American Heart Asso-ciation; Associate Editor, Journal of Lipid Research;Editorial Board, Atherosclerosis, Thrombosis, and Vas-cular Biology.

Danuser, G.Associate Editor, IEEE Transactions onImage Processing; Editorial Board, Biophysical Journal.

Dawson, P.E.Member, Faculty in Chemical Biology,Faculty 1000, Biology Reports, Ltd.; Editorial Boards,International Journal of Peptide Research and Thera-peutics, Letters in Peptide Science.

Dyson, H.J.Editorial Boards, Journal of MagneticResonance, Biophysical Journal.

Elder, J.H.Editorial Boards, Virology, Journal of Virology.

Gascoigne, N.R.J.Member, Program Committee, Ameri-can Association of Immunologists; Member, Cellular andMolecular Immunology A Study Section, National Insti-tutes of Health; Section Editor, Journal of Immunology.

Gerace, L.Editorial Boards, Journal of Cell Biology,BMC Cell Biology.

Goodin, D.B.MERIT Award, National Institutesof Health.

Gottesfeld, J.M.Associate Editor, Journal of BiologicalChemistry.

Havran, W.L.Editorial Board, Immunological Reviews.

T H E S C R I P P S R E S E A R C H I N S T I T U T E 2 0 0 7 3 7 5

Janda, K.D.Section Head, Faculty in Chemical Biol-ogy, Faculty 1000, Biology Reports, Ltd.; EditorialBoards, Chemical Reviews, Journal of MedicinalChemistry, Combinatorial Chemistry Research andApplications, Bioorganic and Medicinal ChemistryLetters, Bioorganic and Medicinal Chemistry, Combi-natorial Chemistry High-Throughput Screening.

Johnson, E.F.Editor-in-Chief, Drug Metabolism andDisposition; Editorial Board, Molecular Pharmacology.

Joyce, G.F.Member, National Academy of Sciences;Member, External Advisory Board, Beckman Institute,California Institute of Technology, Pasadena, Califor-nia; Head, Faculty in Chemical Biology, Faculty 1000,Biology Reports Ltd.; Associate Editor, EvolutionaryComputation, Origins of Life and Evolution of theBiosphere.

Kenny, P.J.Travel Fellow, Winter College on BrainResearch, Snowmass, Colorado.

Lerner, R.A.Doctor of Science, honoris causa, OxfordUniversity, Oxford, England; 35th John Stauffer Lec-ture in Science, University of California, Los Angeles;Editorial Boards, Bioorganic and Medicinal Chemistry,Bioorganic and Medicinal, Chemistry Letters, CatalysisTechnology, Drug Targeting and Delivery, Journal ofVirology, Molecular Biology and Medicine, Molecular,Medicine, Vaccine, Angewandte Chemie.

Lotz, M.President, Osteoarthritis Research SocietyInternational; Member, Skeletal Biology and SkeletalRegeneration Study Section, National Institutes ofHealth; Member, Faculty in Medicine, Faculty 1000,Biology Reports, Ltd.; Associate Editor, ArthritisResearch and Therapy; Editorial Boards, Biotherapy,Osteoarthritis and Cartilage, Journal of OrthopedicResearch, Modern Rheumatology.

Miles, L.A.Chair, American Heart Association WesternStates Affiliate Young Investigators Forum; Chair, Ameri-can Heart Association Western States Affiliate PeerReview Committee 4B; Member, Faculty 1000, BiologyReports, Ltd.; Editorial Board, Frontiers in Bioscience.

Milner, R.Harry Weaver Neuroscience Scholar Award,National Multiple Sclerosis Society.

Mosier, D.E.Editorial Board, Journal of Virology.

Nicoalou, K.C.ISHC Senior Award Lecturer in Hetero-cyclic Chemistry International Society of HeterocyclicChemistry; Honorary Fellowship, Indian Academy ofSciences; Joshua Jortner Distinguished Lecturer in

Chemistry, Tel Aviv University, Tel Aviv, Israel; Co-Edi-tor-in-Chief, Chemistry and Biology; Editorial Boards,Tetrahedron Publications, Synthesis, CarbohydrateLetters, ChemistryA European Journal, Perspectivesin Drug Discovery and Design, Indian Journal ofChemistry, Section B, Current Opinion in BioorganicChemistry, Current Organic Chemistry, CombinatorialChemistry High-Throughput Screening, Organic Letters,ChemBioChem, Chemistry and Biodiversity, Bulletinfor the Chemical Society of Japan, ChemistryAnAsian Journal, International Journal of Oncology.

Oldstone, M.B.A.Fellow, American Academy of Micro-biology; Member, National Academy of Sciences,Institute of Medicine; Elected Member, ScandinavianSociety of Immunology; American Association of Physi-cians; American Society for Clinical Investigation;Member, Scientific Advisory Committee, Pew ScholarsProgram in the Biomedical Sciences; Winford P. Lar-son Award Lecture, University of Minnesota MedicalSchool, Minneapolis, Minnesota; Editor, Virology, Cur-rent Topics in Microbiology and Immunology; EditorialBoards, Immunity, Journal of Clinical Investigation.

Pollard, K.M.Member, External Advisory Committee,Center for Environmental Health Sciences, Universityof Montana, Missoula, Montana; Peer Reviewer, Reporton Assessing the Human Health Risks of Trichloroeth-ylene: Key Scientific Issues, National Research Council.

Polich, J.Editorial Boards, Brain Topography, Brainand Cognition, Journal of Psychophysiology.

Rebek, J., Jr.Distinguished Scientist Award, AmericanChemical Society; Evans Award, Ohio State University,Columbus, Ohio; Creativity Award in Chemistry, Dance,and Music, University of Oregon, Eugene, Oregon;Member, Academia Europaea; Wyeth Lecturer, Prince-ton University, Princeton, New Jersey; Haberman Lec-turer, Marquette University, Milwaukee, Wisconsin;Editorial Boards, Tetrahedron Publications, Bioorganicand Medicinal Chemistry Letters, Bioorganic andMedicinal Chemistry, Journal of the Chemical Soci-etyPerkin Transactions, Chemistry and Biology,Journal of Organic Chemistry, Current Opinion inChemical Biology, Progress in Physical OrganicChemistry, Journal of Supramolecular Chemistry.

Reed, S.I.Editorial Board, Molecular and Cellu-lar Biology.

Reisfeld, R.A.Coeditor, Journal of Clinical LaboratoryAnalysis; Editorial Boards, Bioconjugate Chemistry,

3 7 6 T H E S C R I P P S R E S E A R C H I N S T I T U T E 2 0 0 7

Cancer Biotherapy and Radiopharmaceuticals, CancerImmunology and Immunotherapy, Cancer Research,Clinical Cancer Research, Hybridoma, Interna-tional Journal of Oncology, Journal of Immunology,Tumor Targeting.

Salomon, D.R.Codirector, Center for Organ and CellTransplantation, Scripps Health, Green Hospital, LaJolla, California; Associate Editor, American Journal ofTransplantation; Editorial Board, Transplantation.

Schmid, S.L.MERIT Award, National Institutes ofHealth; Fellow, American Association for the Advance-ment of Science; Board Member and Treasurer,Athena, University of California, San Diego; Member,Study Section for Program Pathway to IndependenceAwards (K99/R00), National Institutes of Health;Editor-in-Chief, Molecular Biology of the Cell.

Sharpless, K.B.Marvel Lecture, University of Illinois,Urbana-Champaign, Illinois; K.T. Wang BioorganicLecture, Institute of Biological Chemistry, Taipei,Taiwan; Johnston Lecture, Emory University, Atlanta,Georgia; American Institute of Physics Nobel Laure-ates Minority Servicing Institutions Visitation Program,Texas Southern University, Houston, Texas; EditorialBoards, Advanced Synthesis and Catalysis, Arkivoc,Beilstein Journal of Organic Chemistry, Bulletin ofthe Chemical Society of Japan, ChemistryAn AsianJournal, Chirality, Current Opinion in Drug Discoveryand Development, Current Drug Discovery Technolo-gies, Enantiomer, Organic Letters, Synlett, Topics inStereochemistry.

Stevens, R.C.Editorial Boards, Protein Expressionand Purification, Biodrugs, Drug Discovery Today, TheProtein Journal.

Suhr, C.D.Ho-Am Prize in Medicine, Ho-Am Founda-tion, Seoul, Korea.

Sutcliffe, J.G.Member, International Advisory Board,International Institute of Molecular and Cell Biology,Warsaw, Poland; Editorial Boards, DNA and Cell Biol-ogy, Molecular Neurobiology Reviews, Journal of Neu-roscience Research, Journal of Molecular Neuroscience,Advances in Neuroscience, Journal of Neurochemistry.

Torbett, B.E.Consultant, Center for Biologics Evalua-tion and Research Response, Food and Drug Adminis-tration, States as Certifiers; Member, AIDS Molecularand Cellular Biology Study Section, National Instituteof Allergy and Infectious Diseases; Reviewer, SpecialEmphasis Panel, Program Project in Myeloid Biology,National Heart, Lung, and Blood Institute.

Vogt, P.K.Heinrich Pette Lecture, University of Ham-burg, Hamburg, Germany; Chairman, Scientific Advi-sory Board, Oncogene Research Institute, University ofSingapore; Member, Selection Committee, Robert KochFoundation; Member, Board of Directors, Foundationfor Advanced Cancer Studies; Editorial Boards, Virol-ogy, Journal of Virology, Current Topics in Microbiol-ogy and Immunology, Cancer Research, Proceedingsof the National Academy of Sciences, Blood Cells,Molecules and Diseases, Cell Cycle.

Weissmann, C.Sackler Lecture, Massachusetts Insti-tute of Technology, Boston, Massachusetts; InauguralSpeaker, Professor Severo Ochoa Lectures, New YorkUniversity, New York, New York; Editorial Board, Prion.

Whitton, J.L.Chair, Special Study Section on VaccineDevelopment, National Institutes of Health; Member,Advisory Committee on Fellowships, National MultipleSclerosis Society; Member, Advisory Board, BurroughsWellcome Fund; Ad Hoc Member, Experimental Virol-ogy and Virology study sections, National Institutes ofHealth; Editor, Virology; Acting Editor-in-Chief, ViralImmunology; Editorial Boards, Journal of Virology,FEMS Medical Microbiology and Immunology.

Wilson, I.A.Fellow, Royal Society of London; Fellow,American Academy of Arts and Sciences; Member, Sci-entific Advisory Board, Keystone Symposia; AssociateEditor, Journal of Molecular Biology, Immunity; EditorialBoards, Science, Journal of Experimental Medicine.

Wittenberg, C.Editorial Board, Molecular and Cellu-lar Biology.

Wright, P.E.Editor-in-Chief, Journal of Molecular Biol-ogy; Editorial Boards, Biochemistry, Current Opinionin Structural Biology, Journal of Biomolecular NMR.

Wthrich, K.Editor-in-Chief, Journal of BiomolecularNMR; Associate Editor, Advanced Science Letters;Editorial Boards, Biochimie, Biomolecular NMRAssignments, Biopolymers, ChemBioChem, ChemicalPhysics Letters, Current Opinion in Structural Biol-ogy, IUBMB Life, Journal of Magnetic Resonance,Journal of Membrane Biology, Journal of Structuraland Functional Genomics, Proteins, Structure.

Yagi, T.Special Reviewer, Neural Oxidative Metabo-lism and Death Study Section, National Institutes ofHealth; Editorial Board, Journal of Bioenergeticsand Biomembranes.


Kellogg School of Science and Technology

In 2007, the graduate program again had manyaccomplishments. At the beginning of the year, thegraduate office processed more than 400 domesticand international applications to the Kellogg School ofScience and Technology. During 3 weekends in Febru-ary and March, visiting students were immersed in asocial and academic whirlwind, including interviewswith faculty and opportunities to speak with currentstudents. The admissions committees offered positionsto 97 students; 32 accepted the offer, including 2 stu-dents who will study on the Florida campus (amongthem, the first biologist) and 3 Skaggs Oxford Scholars.

During the spring, the graduate program deans ini-tiated an external review of the administration of thegraduate program. The review panel, which consists ofW. James Nelson, Stanford University; Michael A. Mar-letta, University of California, Berkeley; Joanne Chory,The Salk Institute; and Larry Overman, University of Cal-ifornia, Irvine, met privately with students, faculty, andother groups to determine if adequate staffing was inplace to maintain the programs momentum of success.

In May, the annual commencement ceremony wasagain held at the Neurosciences Institute. Among the27 graduating students was the first from the Floridacampus, Porino Va. Marye Anne Fox, chancellor ofthe University of California, San Diego, gave the com-mencement address and received an honorary degree.

The new students started to arrive on the ScrippsResearch campuses in the summer. Events to easetheir transition included a luncheon with the dean andassociate deans, a picnic with the continuing students,and orientations by the graduate office and the humanresources department. At the beginning of August, thenew students began the required Critical Thinking andCommunication in Science course developed by Fran-cisco Asturias and Ashok Deniz, which includes infor-mation on applying for National Science Foundationand other fellowship awards.

The annual student/faculty symposium, held at theBahia Resort Hotel on Mission Bay, kicked off the aca-demic year for continuing students in California andFlorida. For the first time, Skaggs Oxford Scholars whoreside in the United Kingdom also attended the sympo-sium. Christopher Vanderwal, 2004 chemistry alumnusand professor at University of California, Irvine, wasguest speaker. A total of 165 students presented posters,and 17 students gave oral presentations. The gather-ing was honored to have Scripps Research trustee A.Brent Eastman, medical director, Scripps Health, jointhe luncheon.

As in previous years, the stipends and tuitions ofthe Kellogg School students were supported by gener-ous donations from individuals, foundations, and cor-porations, including gifts from the American ChemicalSociety, the ARCS Foundation, Inc., the Ann and BillBauce Family Foundation, the Donald E. and Delia B.Baxter Foundation, David and Ursula Fairchild, theGilula Memorial Fund, the Hertz Foundation, theFletcher Jones Foundation, the Koshland Foundation,Novartis, the Gustavus and Louise Pfeiffer ResearchFoundation, Lesly Starr Shelton, and the AndreaElizabeth Vogt Memorial Fund.

The administration of the Kellogg School continuesto work on the 3-year process for reaccreditation. Theinstitutional proposal to the Western Association ofSchools and Colleges was accepted on the first sub-mission, and the review panel considered it exemplary.The proposal is now being used as a model for otherinstitutions involved in the process. A survey is beingdeveloped for distribution to the students, faculty, and


Jeffery W. Kelly, Ph.D.

alumni to evaluate the overall effectiveness of graduateeducation at the Kellogg School.

With a graduate student population of 234, includ-ing 10 Florida students, 8 Skaggs Oxford Scholars, and2 University of California, San Diego, Medical Scientist

Training Program (M.D./Ph.D.) students, the facultyand administration of the graduate program are prepar-ing to face new challenges as these diverse intellectualindividuals begin their careers in science.


S T U D E N T S I N

C H E M I S T R Y A N D

C H E M I C A L B I O L O G Y

P R O G R A M S

Adrian AccursoDartmouth College, B.A.

Klaus AlbertshoferState Agriculture Egineering

School (Germany), B.S.

Erin Anderson Illinois Wesleyan University,

B.A.

Robert AversaCornell University, B.A.

Daniel Bachovchin Harvard College, A.B.

Catherine BarglowStanford University, B.S.

Robert BatesMassachusetts Institute of

Technology, B.S.

John Beierle Boston College, B.S.

Jacqueline Blankman Northwestern University, B.A.

William BrenzovichCollege of William and Mary,

B.S.

Steven BrownUniversity of Wisconsin,

Madison, B.S.

Noah BurnsColumbia University, B.A.

Bradley CharetteUniversity of Nebraska, B.S.

Jason ChenHarvard University, A.B.

Ming ChenBrown University, M.S.

Johnathan ChittuluruCornell University, B.A.

Chung-Han ChuNational Taiwan University,

B.S.

Ryan ClarkUniversity of California, San

Diego, B.S.

Elizabeth CulybaCollege of William and Mary,

B.S.

Trevor DaleSimon Fraser University, B.S.

Stephen DeanVanderbilt University, B.S.

Jessica DeMartinoUniversity of Delaware, B.S.

Michael DeMartinoUniversity of Delaware, B.S.

Damian EkiertUniversity of Chicago, B.A.

Shelby ElleryCedar Crest College, B.S.

Michael FrederickUniversity of Minnesota, B.S.

Brian FrezzaCarnegie Mellon University,

B.S.

Thomas GajUniversity of Arizona, B.S.

Joie GarfunkleBoston College, B.S.

Christine Fang GelinUniversity of California, Los

Angeles, B.S.

Ramesh GiriTribhuvan University, M.Sc.

Yevgeniy GrigoryevCity University of New York,

B.A.

Carlos GuerreroHarvard University, B.A.

Benjamin HafensteinerUniversity of Rochester, B.A.

Geoff HalvorsenUniversity of Illinois, B.S.

David HarrisCornell University, B.A.

Jennifer HazenFranklin and Marshall

College, B.A.

Simon HilcoveArizona State University, B.S.

Vu Hong University of California,

Berkeley, B.S.

Wooyoung HurPohang University, B.S.

Yoshihiro IshiharaMcGill University, M.S.

Valer JesoMassachusetts Institute of

Technology, B.S.

Robert JonesDuke University, B.S.

Daisuke KatoUniversity of California,

Davis, B.S.

Stephanie KazaneBoston College, B.S.

Dong-In KooBrown University, B.S.

Paul KrawczukNew York University, B.S.

Tun-Hsun KuoNational Taiwan University,

M.S.

Sen Wai KwokUniversity of California, San

Diego, B.S.

James LajinessHope College, B.S.

Jonathan LamUniversity of British

Columbia, B.S.

Jolene LauCalifornia Institute of

Technology, B.S.

Aaron Leconte Carleton College, B.A.

Hyun Soo LeePohang University, M.S.

Sangyeul LeeUniversity of California,

Berkeley, B.S.

Ang LiPeking University, B.S.

Weiwei LiNational University of

Singapore, M.S.

Yee Hwee LimUniversity of Bristol, B.Sc.

David LinStanford University, B.S.

Ricardo LiraUniversity of California, San

Diego, M.S.

Ewa LisCornell University, B.A.

Chang LiuHarvard University, B.A.

Jonathan LocknerUniversity of Illinois,

Urbana-Champaign, B.S.

Jonathan LongColumbia University, B.A.

Andre LoutchnikovUniversity of Toronto, M.S.

Colin LoweryUniversity of Virginia, B.S.

Costas LyssiotisUniversity of Michigan, B.S.

Karen MacMillanUniversity of California,

Davis, B.S.

Thomas MaimoneUniversity of California,

Berkeley, B.S.

Dena MarrinucciUniversity of Vermont, B.S.

Tiansheng MeiLanzhou University, B.S.

Jeremy MillsVanderbilt University, B.S.

Timothy NewhouseColby College, B.A.

Christine NguyenBoston College, B.S.

Andrea NoldIndiana University, B.S.

Daniel OMalleyRice University, B.S.

Derrick OngNational University of

Singapore, M.S.

Adrian OrtizUniversity of Arizona, B.A.

Katerina Otrubova San Diego State University,

M.S.

Paresma PatelUniversity of North Carolina,

Chapel Hill, B.S.

Francis PetersUniversity of New South

Wales, B.S.

Rajan PraganiGoucher College, B.A.

Benjamin PrattDartmouth College, B.A.

Stanislav PresolskiColby College, B.A.

Jessica RaushelTexas A&M University, B.S.

Timothy ReichartUniversity of Virginia, B.S.

Jeremy RichterButler University, B.S.

Tucker RobertsVanderbilt University, B.S.

William RobertsonUniversity of Colorado, B.A.

David SarlahUniversity of Ljubljana, B.S.

Martin SchnermannColby College, B.A.

Ian SeipleUniversity of California,

Berkeley, B.S.

Ryan ShenviPennsylvania State

University, B.S.

Jun ShiWuhan University, B.S

Sarah SiegelUniversity of Virginia, B.S.

Corin SlownYale University, B.S.

James SolomonUniversity of California, San

Diego, M.S.

Theresa TiefenbrunnCalifornia Institute of

Technology, B.S.

Jennifer TreweekCalifornia Institute of

Technology, B.S.

George Scott TriaBoston University, B.A.

Hillary Van AndaBryn Mawr College, A.B.

Amira Moreno VeraUniversity of Pennsylvania,

B.A.

Florina VoicaSmith College, B.A.

Donghui WangLanzhou University, B.S.

Jianhua WangUniversity of Montreal, M.S.

Sheng-Kai WangNational Tsing Hua

University, B.S.

Masayuki WasaBrandeis University, B.S.

John WhitakerWashington State University,

B.S.

Landon WhitbyUniversity of Utah, B.S.

SusAnn WinbushUniversity of California, Los

Angeles, B.S.

Isaac YonemotoUniversity of Chicago, B.S.

Travis YoungBoston College, B.S.

Wayne YuPortland State University, B.S.

Andrea ZuhlNorthwestern University, B.A.

S T U D E N T S I N B I O L O G Y

A N D B I O P H Y S I C S

P R O G R A M S

Phillip AotoUniversity of California,

Irvine, B.S.

Kathryn ApplegateCentenary College, B.S.

Rena AstronomoSimon Fraser University, B.S.

Michael BarnesUniversity of Notre Dame,

B.S.

Gira BhabhaUniversity of Chicago, B.A.

Eric BrustadPurdue University, B.S.

Anne BunnerIowa State University, B.S.

Russell BurgeArizona State University, B.S.

Stuart CahalanUniversity of California, San

Diego, B.S.

Joshua ChappieBrandeis University, M.S.

Stephen ChenRice University, B.S.

Yee-Ting ChongCornell University, B.A.

Eugene ChunUniversity of California,

Berkeley, B.A.

Ronald ColemanCalifornia State University,

Fullerton, B.S.

Corey DambacherSan Diego State University,

M.S.

Lorenzo de LichterveldeUniversity of Louvain, B.S.

Neekesh DhariaUniversity of California, San

Diego, B.S.

Melissa DixPennsylvania State

University, B.S.

Bao DuongUniversity of California, Los

Angeles, B.A.

Hunter ElliotColorado College, B.A.

Jason FiedlerUniversity of Minnesota, B.A.

Kelly FlanaganSaint Louis University, B.S.

Anna GalkinCornell University, B.S.

Marin GantnerUniversity of Puget Sound,

B.S.

Sulagna GhoshUniversity of Maryland, B.S.

Russell GordleySwarthmore College, B.A.

Daniel GroffAlbertson College, B.S.

Jing GuoPeking University, B.S.

Peter HawkinsBrigham Young University,

B.S.


WeiWei HeUniversity of Science and

Technology of China, M.S.

Christine Johanna HeidekerJulius Maximilians Universitt

Wrzburg, Diplom.

Ronald HillsFlorida State University, B.S.

David HorningHarvard University, A.B.

Amanda HoytUniversity of Washington, B.S.

Julie HsuUniversity of California,

Berkeley, B.A.

Pei-hsin HsuStanford University, M.S.

Audra JohnsonSan Francisco State

University, B.S.

Graham JohnsonJohns Hopkins University,

M.A.

Paul JohnsonUniversity of Minnesota, B.S.

Angeldeep KaurBryn Mawr College, B.A.

Piotr KazmierczakUniversity of Warsaw, M.Sc.

Donald KerkowUniversity of California, San

Diego, B.S.

Christopher KimberlinUniversity of California,

Santa Barbara, B.S.

Robert KirchdoerferUniversity of Wisconsin,

Madison, B.S.

Marina KolesnichenkoDartmouth College, B.A.

Heather Kiyomi KomoriAlbertson College, B.S.

Kristopher KoudelkaUniversity of Wisconsin,

River Falls, B.S.

Sherman KuGeorgia Institute of

Technology, B.S.

Jinny KwongUniversity of California, San

Diego, B.S.

Gabriel LanderState University of New

York, Binghamton, B.S.

Pick-Wei LauUniversity of Arizona, M.S.

Daniel LeamanUniversity of Pittsburgh, B.S.

Marvin Jie Rong LeeImperial College London,

B.Sc.

James LimMcGill University, B.S.

Tracey LincolnWilliams College, B.A.

Jingyun LiuUniversity of California,

Berkeley, B.A.

Jiaozhi LuUniversity of Alberta, B.S.

Victor Mitch LunaStanford University, B.S.

Rajan MannigeUniversity of Houston, B.S.

Katherine MarcucciNorthwestern University, B.A.

Christopher MartinTufts University, B.A.

Alexandre MatovTechnical University Varna,

M.Sc.

Mayako MichinoGeorgia Institute of

Technology, M.S.

Takashi MiyamotoUniversity of Tokyo, B.S.

Crystal MoranArizona State University, B.S.

Crystal MoyerUniversity of Pittsburgh, B.S.

Anke MulderPurdue University, B.S.

Amber MurrayMassachusetts Institute of

Technology, B.S.

Sherry NiessenMcGill University, M.S.

Katherine PetrieUniversity of Pittsburgh, B.S.

Emily PlummerUniversity of Utah, B.S.

Katie PodshivalovaUniversity of California,

Santa Barbara, B.S.

Ashley PrattUniversity of Colorado, B.A.

Randor RadakovitsStockholm University, M.Sc.

Sanjeev RanadeNortheastern University, M.S.

William RidgewayUniversity of California,

Berkeley, B.A.

Cory RillahanTufts University, B.S.

Sophie RozenzhakWayne State University, M.S.

Erin SchererUniversity of Arkansas, B.S.

Owen SiggsAustralian National

University, B.S.

Gabriel SimonUniversity of Pittsburgh, B.S.

Peter SmithPurdue University, B.S.

Sevil SofuevaInternational University

Bremen, B.Sc.

Luise SternbergUniversity of California, Los

Angeles, B.S.

Bogdan TanasaGr. T. Popa University of

Medicine and PharmacyIasi, M.D.

Shishi TangUniversity of Toronto, M.S.

Megan ThielgesArizona State University, B.S.

Miller TranUniversity of California, San

Diego, B.S.

Anne-Marie TurnerWake Forest University, B.S.

Lisa TuttleUniversity of Minnesota, M.S.

Sarah VoytekBrown University, B.S.

Laura WalkerUniversity of Wisconsin-

Madison, B.S.

Andrew WardDuke University, B.S.

Peter WatsonCarleton College, B.A.

Stuart WebbUniversity of California,

Santa Barbara, B.S.

Kathryn WeinellUniversity of Colorado, B.A.

Joann WuUniversity of California, San

Diego, B.S.

Fei XuUniversity of Science and

Technology of China, B.S.

Craig YoshiokaUniversity of Florida, B.S.

Jason YoungUniversity of Wisconsin, B.S.


The Center for IntegrativeMolecular Biosciences

The Center for Integrative Molecular Biosciences(CIMBio) was created in 2002 to foster collabo-rative research dedicated to elucidating the high-resolution structures, mechanisms of action, and in vivodynamic behaviors of the cells molecular machines.CIMBio now houses 20 research groups representingdisciplines including chemistry, cell and molecular biol-ogy, electron microscopy, x-ray crystallography, advancedlight microscopy, computational biology, and technol-ogy development. Floyd Romesberg, Philip Dawson,and Anette Schneemann have relocated their researchgroups here, occupying new laboratories on the secondfloor of the building and adding strengths in chemistryand structural biology.

Our faculty members have made a number of note-worthy scientific advances, a fact reflected in the numberof papers published in top-ranking scientific journals.The following list highlights some of this groundbreak-ing science. In the journal Cell, Clare Waterman-Storerand her coworkers described fundamental dynamicmolecular relationships that underlie rapid cell migrationover substrates. Geoffrey Chang and members of his

laboratory published an article in Science describingthe high-resolution structure of a membrane proteintransporter involved in multidrug resistance. Also inScience, Bridget Carragher, Clint Potter, Jack Johnson,and their colleagues reported the structure of an infec-tious phage, including visualization of the capsid; thetightly spooled, packaged DNA; and the tail machinerythat senses when packaging is complete. In an articlepublished in Nature, groups headed by Dr. Carragher,Dr. Potter, and William Balch described the underly-ing structure of the coat protein complex-II molecu-lar cage that mediates intracellular transport. Also inNature, Ron Milligan and colleagues described the mech-anism of minus-end directed motion by a microtubule-bound kinesin. In Nature Medicine, Mari Manchestersgroup reported the use of a fluorescently labeled plantvirus as a biosensor for vascular imaging. This novelmethod can be used to effectively image the completeembryonic vasculature and highlight the process ofangiogenesis in developing tumors.

It was a banner year for Clare Waterman-Storer.She received a number of honors and awards, includingthe R.R. Bensley Award in Cell Biology from the AmericanAssociation of Anatomists, the Directors Pioneer Awardfrom the National Institutes of Health, and an EstablishedInvestigatorship from the American Heart Association.

During November 2005, 41 students from theUnited States, Canada, and Europe attended a 9-daypractical course in molecular microscopy run by theNational Resource for Automated Molecular Microscopy,our Biomedical Technology Resource Center sponsoredby the National Center for Research Resources. Leadingscientists in the field participated in lectures, researchseminars, and practical sessions that covered the theoryand practice of electron microscopy and image analysis.The formal lectures and research seminars attractedmany attendees from the local scientific community. Inall, 27 instructors and 18 assistants were involved inthe course. Financial support for the course was pro-vided by the National Center for Research Resources;the Agouron Institute; FEI Company; Gatan Inc.; Pro-tochips Inc.; Tietz Video and Image Processing Systems;and Scripps Research.

The fourth in a series of training workshops on soft-ware for automated molecular microscopy was held inFebruary 2006. Representatives from 5 institutions(Oxford; Purdue; Brandeis; University of California,San Diego; and State University of New York) attendedand received intensive training on installation and use


Ronald A. Milligan, Ph.D.

Harold L. Dorris NeurologicalResearch InstituteT. Bartfai, Ph.D., Director

Major depression and schizophrenia affect mil-lions of people. Treatment of these conditionsrequires an understanding of their underpin-

nings, and this need is addressed by the Harold L. Dorris

Neurological Research Institute. Founded in 1999 as

the result of a $10 million long-term commitment by

Helen L. Dorris through the Harold L. Dorris Foun-

dation, named in her brothers honor, the institute has

attracted an international cadre of scientists from France,

Switzerland, Sweden, Mexico, and Italy in such disci-

plines as neurology, immunology, chemistry, molecular

biology, and endocrinology to study neurologic disorders.

The institute also funds the Helen Dorris Fellow in

Schizophrenia, a named fellowship position for a post-

doctoral researcher to study aspects of schizophrenia

and depression from the neurobiological perspectives.

The current fellow is Olivia Osborn, from Oxford Uni-

versity in England. The visiting professors at the insti-

tute in 2006 were the noted electrophysiologist and

member of the French Academy of Sciences Henri Korn

from the Pasteur Institute in Paris, France; noted phar-

macologist and member of the Royal Swedish Academy

of Sciences Lars Terenius from the Karolinska Institutet

in Stockholm, Sweden; and molecular immunologist

Hermann Gram from Basel, Switzerland.

In 2006, the faculty of the institute expanded beyond

the founding members with the election of 2 talented

young faculty members: Marisa Roberto, who is working

on substance addiction, and Dorian McGavern, who is

working on clearance of viral infections from the brain.

of software developed at the National Resource forAutomated Molecular Microscopy.

In the coming year, Scripps Research will be thefirst research institution worldwide to receive a novelcompact synchrotron light source. This Scripps campussynchrotron, to be housed in CIMBio, will significantlyaccelerate the pace of determining challenging proteinstructures (e.g., membrane proteins and large macro-molecular complexes) and structure-based drug designby enabling real-time experimental evaluation with high-intensity, tunable x-rays. This research is part of the newtechnology developments of the Accelerated TechnologiesCenter for Gene to 3D Structure (http://www.atcg3d.org)in the laboratories of Peter Kuhn and Raymond Stevens.

These activities and successes during the past yearhighlight the collaborative, interdisciplinary nature ofthe science being carried out at CIMBio. The enthusiasmof our faculty, staff, fellows, and students and their com-mitment to our collaborative mission are also evident atthe standing-room-only biweekly forumsshort seminarsdesigned to promote interdisciplinary interactions.


Tamas Bartfai, Ph.D.

The Institute for Childhood andNeglected Diseases

The Institute for Childhood and Neglected Diseases(ICND) was established to apply cutting-edgeresearch to understand the basic mechanismsthat underlie diseases of childhood and orphan diseasesthat lack efficacious treatments. Diseases of both cat-egories often affect populations in developing countries,where the health infrastructure may be too poor to sup-port major research efforts on these problems.

Examples of such diseases include malaria, epilepsy,mental retardation, cystic fibrosis, chronic pain, andsleep disorders. The human and economic costs ofthese diseases are staggering. According to the WorldHealth Organization, each year, the microorganism thatcauses malaria infects 300 million persons, and the

Helen L. Dorris Child andAdolescent Neuro-PsychiatricDisorder Institute

The sequencing of the human genome promisesto propel humans into the age of molecular medi-cine, where complex diseases are diagnosed andtreated in a patient- and target-specific manner. For the

nervous system, in particular, the postgenome era holdsthe potential to deliver groundbreaking new medicinesfor previously intractable psychiatric disorders includ-ing anxiety, depression, and schizophrenia.

However, in order to realize this goal, a new breedof research institute is needed that cultivates cross talkamong many experimental disciplines. Indeed, unravel-ing the complexities of the human brain and behaviorcan only be achieved by bringing together scientists fromdiverse backgrounds and expertise, including chemistry,physics, genetics, and behavior.

The Helen L. Dorris Child and Adolescent Neuro-Psychiatric Disorder Institute was established with agenerous gift from mental health advocate and San DiegoState University professor emeritus Helen L. Dorris. Herinterest in mental health advocacy led her to providethe funding to establish this institute, which has a strongemphasis on interdisciplinary approaches to studies ofneurologic and psychiatric disorders.

Specifically, the aim of scientists at the institute isto uncover the pathologic basis of mental disorders andto develop therapies for these disorders. Several tal-ented investigators have been recruited to join the insti-tute. Together, these investigators are addressingmany of the most challenging problems facing contem-porary molecular and behavioral neuroscience. Theirresearch promises to uncover fundamental mechanismsfor brain function and to reveal novel strategies andtargets for the treatment of nervous system disorders.


Ben Cravatt, Ph.D.

Steve Kay, Ph.D.

disease kills approximately 1 million persons. About90% of the people who have malaria are in Africa,where the annual costs associated with the diseaseare $12 billion. Malaria is the leading cause of child-hood mortality in African countries.

Epilepsy is another widespread and costly disease.It affects about 2.3 million persons in the United Statesand accounts for $12.5 billion in medical costs andreduced productivity each year.

Mental retardation is another condition that affectschildren everywhere; about 1% of American children3 to 10 years old have mental retardation. During the19951996 school year, about 600,000 6- to 21-year-olds with mental retardation in the United Statesreceived special educational services, at a cost ofabout $3.3 billion.

Housed in a state-of-the-art, 54,000-square-footbuilding on the east side of the Scripps Researchcampus, the ICND is a focus group within ScrippsResearch for young scientists who are working in areasrelevant to the ICND mission. The concept of the ICNDgrew out of conversations in 1996 and 1997 amongScripps Research president Richard Lerner; John Moores,who was interested in supporting research on illnessesthat affect people in developing countries; and thebrothers Bernard and Marc Chase, who were inter-ested in supporting research on childhood diseases.John and Rebecca Moores, Bill Bauce, and other auto-mobile enthusiasts donated a number of vintage auto-mobiles, which were auctioned to support the ICND.The Moores went on to contribute a valuable coin col-lection, as well as pledging $5 million to be awardedover 5 years.

The Human Genome Project has led to a deeperunderstanding than ever before of the mechanismsunderlying human disease. The ability to study the draftmouse and human genomes in parallel is providingan unprecedented opportunity to create a road mapfor assigning a physiologic function to all of the35,00045,000 human genes. This formidable chal-lenge requires complex multidisciplinary approachesthat allow scientists to create and implement the mostpowerful research tools available. Investigators at theICND use genomics, proteomics, and advanced micro-scopic imaging technologies; develop many noveltransgenic animal models; and aggressively applythese technologies in an effort to understand themechanisms of action of a variety of diseases andconditionsmalaria, mental retardation, neurodegen-

erative diseases, neuropathic pain, deafness, sleepdisorders, migraines, and epilepsy, for exampleandto devise treatments for these maladies. ICND scien-tists plan to systematically study not only the genesassociated with these abnormalities but also the inter-actions between the genes in living model systems.

ICND researchers have already been recognized bythe international scientific community during the first6 years of the institutes existence. In December 2002,3 of the highly prized Top Ten Breakthroughs of theYear of Science magazine were results produced byICND researchers working on the malarial genome,mechanisms of pain perception, and processes impor-tant for sleep disorders and seasonal depression. Thisremarkable level of achievement speaks to the invest-ment made in these research areas and bodes well forfurther rapid progress in the future.

Faculty Areas of Research

Steve A. Kay, Ph.D. Molecular mechanisms of circa-dian rhythms and sleep disorders,genetics of anxiety, novel targetsin neurodegenerative diseases

William E. Balch, Ph.D. Protein trafficking and the molec-ular basis for the hereditary child-hood disease cystic fibrosis

Kristin Baldwin, Ph.D. Molecular biology of the sense ofsmell, genetic mechanisms gov-erning neural circuit developmentin the olfactory system and cortex

Shelley Halpain, Ph.D. Organization and function of theneuronal cytoskeleton, mecha-nisms underlying potential treat-ments for Alzheimers diseaseand repair of neuronal damageafter trauma

Mark Mayford, Ph.D. Molecular basis of cognitivefunction, including learning andmemory disabilities and mentalretardation

Ulrich Mller, Ph.D. Molecular cell biology of mecha-nosensory perception and child-hood deafness

Ardem Patapoutian, Ph.D. Ion channels and receptorsinvolved in nociception and neu-ropathic pain

Elizabeth Winzeler, Ph.D. Functional genomic approaches toidentifying targets in Plasmodium,the parasite that causes malaria


Society of Fellows

In its 45th year, the Society of Fellows took pride inmaintaining its mission to serve the scientific com-munity at Scripps Research, with particular emphasison enhancing the trainee experience of junior scientists.We enjoyed a great year of bringing graduate students,postdoctoral fellows, and faculty members together inboth professional and social arenas.

Our Distinguished Lecturer Series brought severalprominent Nobel Laureates to lecture and, more impor-tantly, to interact with postdoctoral scholars. The soci-ety is thankful to the speakers, Sydney Brenner andAndrew Fire, for their excellent presentations.

The society also sponsored a wide range of careerdevelopment workshops and seminars, most notablyseveral postdoctoral career events. Events included aSan Diego lab management course for senior postdoc-torl scholars and junior faculty, talks by an industrycareer panel, a nonindustry career panel, and an eti-quette workshop and reception for postdoctoral schol-ars. These events were sponsored in partnership withRyan Wheeler, manager of the Office of PostdoctoralServices, which has greatly expanded our reach by pro-viding help in organizing events. We acknowledge Ryansoutstanding assistance and appreciate his commitmentto fulfilling the societys aims.

The Fall Research Symposium was organized todraw postdoctoral scholars, graduate students, andfaculty members together in an informal setting. Theevent, held in the Beckman Galleria, featured 72 posterand oral presentations covering research projects fromall departments.

This years social calendar was again packed withmany entertaining events, including trips to the opera(Don Giovanni in Orange County), a camping trip onCatalina island, and our annual Big Bear ski trip. Monthlyhappy hours were held to promote interaction amongscientists at Scripps Research and at nearby scienceinstitutions. This years summer bash was held at theHilton Torrey Pines in La Jolla. In addition, our Hal-loween yacht party was a memorable event with acruise around San Diego Bay. Other notable socialevents this year included a day at the Del Mar races,a hockey night at Anaheim, and a spring party atRock Bottom. The society also sponsored a play bythe Scripps Research drama group called the MobilityPond; the play was very well attended and enjoyed byall. We have also launched our first quarterly newsletter,which will keep the scientific community at ScrippsResearch abreast of all the societys events.

Finally, at the annual spring vendor show, thesociety played host to approximately 100 scientific ven-dors, who displayed their latest scientific equipmentand technology.


S O C I E T Y O F F E L L O W S E X E C U T I V E C O M M I T T E E : Left to right: back row: Kaustav Datta, Hunter Elliott, Gunnar Poplawski,

Stephan Meister, Geza Ambrus-Aikelin, Steve Johnson, Scott Westenberger, Ryan Wheeler, Ralph Pantophlet, BinQing Wei, Jilla Sabeti,

Roshni Mitra Chintalapati; front row: Anne Bellon, George Nicola, Vandana Ramachandran, Althea Capul, Olivier Harismendy.

The Society of Fellows executive committee expressesits sincere gratitude to the Office of the President andPostdoctoral Services at Scripps Research for enthusi-astic and continued support of the societys activities.

E X E C U T I V E C O M M I T T E E 2 0 0 6 2 0 0 7

Officers

Vandana Ramachandran President

George Nicola Vice President

Olivier Harismendy Treasurer

Stephan Meister Social Cochair

Althea Capul Social Cochair

Kaustav Datta Distinguished Lecturer Series Chair

BinQing Wei Career Development Committee Cochair

Steve Johnson Career Development Committee Cochair

Florence Brunel Vendor Show Cochair

Anne Bellon Vendor Show Cochair

Roshni Mitra Chintalapati Newsletter Editor

Ryan Wheeler Postdoctoral Services Office Liaison

Jilla Sabeti Network for Women in Science Liaison

BinQing Wei Website Comanager

George Nicola Website Comanager

Gunnar Poplawski Graduate Liaison

Others

Geza Ambrus-Aikelin Ralph Pantophlet

Michael Huber Chris Ramsey

Tina Marie-Mullen Scott WestenbergerLars Pache

Network for Women in Science

The Network for Women in Science (NWiS) atScripps Research was founded by graduate stu-dents, postdoctoral fellows, and faculty in 2003.In the past 4 years, NWiS has strived to provide sup-port, guidance, and opportunity for female scientistsat Scripps Research; create awareness of issues thataffect scientific career development and success; pro-mote diversity at Scripps Research; and make a posi-tive difference in the culture of science for the benefitof the entire scientific community.

During the past year, NWiS sponsored severalevents for career development and networking for juniorscientists at Scripps Research. NWiS has hosted men-toring lunches at which junior scientists have theopportunity to informally connect with Scripps Researchfaculty. These lunches have provided a unique opportu-nity for networking across departments. In addition,NWiS has collaborated with the Kellogg School of Sci-ence and Technology Distinguished Lecturer Series.Through the Distinguished Lecturer Series, we havehosted 2 outstanding female scientists, Dr. Erin OSheafrom Harvard University and Dr. Elaine Fuchs fromRockefeller University. These leaders in their fields metinformally with NWiS members to discuss obstaclesand opportunities that arose throughout the lectur-ers careers.

The NWiS officers express their appreciation tothe Kellogg School of Science and Technology for itsenthusiastic support of NWiS activities. In addition, wethank the following faculty for their participation andsupport of NWiS events: Linda Sherman, Erica Oll-man-Sapphire, Bridget Carragher, Natasha Kralli, ClareWaterman-Storer, Sandra Schmid, Jamie Williamson,Kerry Mowen, Kathryn Crossin, and Kristin Baldwin.

Officers 20062007

Anne Bunner Cochair

Kiyomi Komori Cochair

Jilla Sabeti Secretary


A U T H O R I N D E X

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340Partridge, J.P. 66Patapoutian, A. 65Patel, P. 84Patel, S. 223Pathak, R. 129Paulson, J.C. 266Pavlickova, P. 304Pawlak, J. 67Pawlinski, R. 147Payne, R.J. 107Payton, S. 116Pebernard, S. 260Pecheniuk, N. 312Pedrini, B. 207Pejchal, R. 190Pellequer, J.-L. 314Pelletier, N. 148

Pelmenschikov, V. 220, 222Pendri, K. 97Pendyala, G. 325Peng, H. 299Peng, X. 98Peram, M.M.R. 106Perego, M. 293295Perera, R. 103Perez-Pinera, P. 302Perlman, S.L. 217Perna, A. 163Perry, J.J. 197Peters, F. 103Petersen, H. 157Peterson, L.F. 306Peterson, S. 265Petrie, H.T. 33Petrie, K.L. 238Petrillo, J.E. 252Petrovan, R.J. 133Petrovic, G. 97Pham, D. 352Philipson, L.H. 71Phillips, E. 332Pian, J. 332Pilotte, J. 360, 363Pinacho Crisotomo, F.R. 17Piomell, D. 339Pique, M.E. 195, 197, 225Piran, R. 243Pitman, J.L. 23Pitram, S. 104Placzek, W.J. 207Pletcher, M.T. 27Pljevaljcic, G. 218Ploplis, V.A. 62Plutner, H. 45Poceta, J.S. 336Podda, G.M. 284Poddutoori, R. 98Podshivalova, K. 141Polat, T. 107Polet, D. 97Polich, J. 336Polis, I. 114, 117Pollard, K.M. 311Pond, S. 218Pontremoli, G. 97Poplawski, G. 55Pottekat, A. 45Potter, C.S. 47Powers, E.T. 95Powers, M.E. 100Pragani, R. 102Prasad, S. 351Pratt, B. 97Presolski, S. 89Priest, A. 22Prieto, H. 70Prinsen, R. 286Prinsen, R.C. 291Prudden, J. 260Pruneda, J. 22Przydzial, M. 27Pucadyil, T. 68Puckett, C. 163Puga, M. 106Pulcinelli, F.M. 288Pulokas, J. 47Pulvirenti, L. 114Purcell, R.H. 296Purdy, R.H. 114


Purton, J.F. 161Qiang, Z. 57Quello, S. 114, 116Quigley, J.P. 66Quiroz, A.L. 22Quispe, J. 47, 322Radakovits, R. 63Rae, C. 59Rai, M. 217Ralston, R. 152Ramachandran, R. 68Ramasastry, S.S.V. 240, 249Ramos, C. 63, 69Ramsey, C. 161Rao, P. 95Rao, S. 116Ratner, T. 243Raushel, J. 91, 104Rayl, T. 84Razi, N. 266Razvi, A. 45Reany, O. 243Rebek, J., Jr. 17Reddy, R. 234, 236Reddy, V. 153, 223Reddy, V.S. 251Reed, S.I. 255Reijmers, G.J. 61Rein, A. 71Reisfeld, R.A. 154Reixach, N. 307Repunte-Canonigo, V. 338Restorp, P. 17Reyes, C.L. 199Reynald, R.L. 278Reynolds, A. 63Reynolds, K. 98Rhee, J.K. 207Richards, M.R. 133Richardson, H.N. 114Richter, J.M. 83Ridgeway, W. 233Riewald, M. 155Ring, G. 233Rios, K. 337Rivas, F. 97Rivera, R. 265Roberto, M. 114, 120, 339,

340Roberts, A. 307Roberts, A.J. 337, 340Roberts, E. 98, 156Roberts, J. 284Roberts, T.C. 100Robertson, W. 84Rodionov, V. 89Rogel, J. 106Rojek, J.M. 330Romero, A. 84Romesberg, F.E. 100Rosen, H. 156Rosenstein, R. 225Ross, B. 335Rossier, J. 339Roth, C. 203Roth, J. 102, 332Rounbehler, R. 32Roush, W.R. 102, 156Rowcliffe, E. 131, 168Roy, R.S. 203Roychowdhury-Saha, M. 237Rozenshteyn, D. 314

Rozenzhak, S. 258Rudyak, S. 255Ruf, W. 134, 157Ruggeri, Z.M. 284, 288, 298Ruiz, C. 353, 369Ruse, C.I. 70Ruse, M. 144Russell, P. 258Ryba, T. 102Rybakin, V. 138Ryu, Y. 103Sa Prieto, P. 175Saban, S. 153Sabeti, J. 334Sabino, V. 114, 119Sabouri, M. 50Saez, E. 67Sagle, L.B. 100Saikatendu, K.S. 57, 203Salameh, A. 104Saldanha, A. 229Saldanha, S. 370Salerno, S. 135Sals, N. 175Salisbury, C. 49Salkowitz-Bokal, J. 149Salomon, D.R. 290Salzameda, N. 86, 92Sanathara, N. 143Sanchez, A. 326, 329Sanchez, S. 332Snchez-Alavez, M. 343, 344Sanchez Ruiz, A. 97Sanna, G. 156Sanna, P.P. 338Sanner, M.F. 225Sansen, S. 278Santa Marta, M. 240Saphire, E.O. 133, 158Sarlah, D. 97Sasaki, Y. 84Sauer, K. 159Saunders, A.A. 324Savage, B. 284Savage, J.H. 291Savas, . 278Sawa, M. 107Scalfaro, P. 137Scampavia, L. 370Scaramozzino, F. 293Schaeffer, M-.T. 156Schaffner, F. 157Scheele, C. 27Scheraga, H.A. 223Scherer, E.M. 131Schettini, J. 164Schiefner, A. 190Schiller, S. 103Schimmel, P. 234, 236Schmid, S.L. 68Schmidt, M. 65Schneemann, A. 71, 252Schnermann, M. 84Schramm, M. 17Schrantz, N. 163Schrier, R. 291Schroeder, C. 51Schroeder, R. 114Schuepbach, R.A. 155Schultheisz, H. 233Schultz, L.E. 27Schultz, P.G. 103

Schultz, T.F. 22Schwander, M. 63Schweitzer, P. 120, 339, 340Schwimmer, L.J. 240Scorah, J. 259Scott, D. 145Sczaniecka, A. 63Segatori, L. 95Seiple, I.B. 83Seit-Nebi, A. 261Selvarajah, S. 136, 137, 297Semenova, S. 264Seo, B.B. 281Serrano, P. 207Sette, A. 322, 323Sever, M. 103Sevilla, N. 326Sferrazza, G. 175Shabat, D. 240Shadan, F. 116Shaginian, A. 84Sharkey, L. 340Sharpless, K.B. 104Shaw, D. 97She, E. 128Shekhter, T. 51, 243Shenoy, S. 17Shenvi, R.A. 83Shepard, C. 223Sherman, A. 174Sherman, L.A. 160Shi, J. 33, 83, 304Shi, Y. 87Shia, W.-J. 306Shikhman, A. 276Shimada, S. 139Shin, D.S. 197Shin, Y. 353Shivakumar, D. 220Shore, D.A. 190Shoshani, S. 243Sidhpura, N. 341Sidney, J. 323Siefker, D. 60Siegel, S. 95Siggins, G.R. 120, 339, 340,

343Siggs, O. 128Siladi, M.E. 252Simanksi, S. 35Simon, G. 49Singh, P. 59, 251Sinha, M. 243Sinha, P.K. 281Sinha, S. 98Sinha, S.C. 247Sitia, G. 298Siuzdak, G. 231Skog, P. 151Slavin, D. 259Slown, C. 84Smider, V.V. 103, 245Smith, E. 174Smith, J.G. 152, 153Smith, L.H. 353, 372Smith, P.A. 100Sobieszczuk, P. 266Sofia, D. 32Solel, E. 243Sonderegger, M. 231Song, B.D. 106Song, X. 353

Soragni, E. 217Soreni, M. 243Sovath, S. 128Speir, J. 250Spencer, K. 55Sperling, E. 233Spicer, T. 370Spiropoulou, C. 326Sprent, J. 161Stagg, S. 45, 47Stamm, S. 84Stanfield, R.L. 131, 190Steardo, L. 119Steeves, M. 32Stefanko, R.S. 163, 190Steinbrecher, T. 220Steiniger, S. 92Stepan, A. 97Sternik, G. 138Stevens, J. 190Stevens, R.C. 203Stewart, L. 266Stewart, P.L. 153Stinus, L. 114Stouffer, D. 114, 117Stouffer, G. 332Stout, C.D. 200, 201, 253,

254, 291Stover, J. 84Stowers, L. 69Strosberg, A.D. 176Sturny, A. 175Su, S. 83Subbarao, G.V. 251Subramaniam, P. 370Subramanian, V. 57, 203Sudek, S. 206Sue, S.C. 213Sugase, K. 208Sugiyama, M. 107Suk, J.Y. 95Sullivan, L. 370Sullivan, N.L. 133Sun, P. 261Sundstrom, M. 253Supekova, L. 103Surh, C.D. 161Surka, M.C. 68Sutcliffe, J.G. 262264Suzuki, T. 97Swan, C.H. 291Szajner, P. 45Szewczyk, P. 199Szurmant, H. 293Szymczyna, B. 233Tabakof, B. 120Tabarean, I.V. 343, 345Tabarin, A. 114, 119Taffe, M.A. 114, 118Tagoe, C. 307Tainer, J.A. 71, 197Takaoka, L. 84Takeda, A.C. 308Takizawa, S. 84Talbot, A. 97Tan, J. 335Tanaka, F. 240, 249Tang, Y. 97Taniguchi, N. 277Tao, H. 84Tate, S. 47Taurog, R. 250


Taylor, E. 259Taylor, J.A. 71Taylor, K. 142Tellinghuisen, T.L. 177Teng, C. 328Tennant, L.L. 208, 211, 213Teyton, L. 163Theofilopoulos, A.N. 164Thielges, M.C. 100Thomas, D. 59Thomas, E.A. 263Thorpe, I.F. 223Tian, H. 266Tichenor, M. 84Tiefenbrunn, T. 51Tilley, R.E. 147Timmons, J.A. 27Ting, J.P.C. 322324Tiraby-Nguyen, C. 56Tishon, A. 326Torbett, B.E. 253, 286, 291Torres, B. 33Torres-Bacete, J. 281Tortosa, M. 102Toulon, A. 141Tran, M. 60Trauger, S. 231Treadaway, J.C. 177Trenney, R.L. 160Trepanier, V. 97Treweek, J. 92, 337Tria, G. 97Trifilo, M.J. 326, 328Trifiro, E. 288Tripp, J. 104Tripp, M.C. 223, 251Troseth, S.R. 106Trout, T. 206Truksa, J. 299Truong, P. 329Trzupek, J. 84Tsai, S. 217Tsao, M.-L. 103Tsatmali, M. 144Tschan, M.P. 291Tschulena, U. 240Tsuda, M. 277Tuan, T. 199Tubbs, J.L. 195Turner, C. 17, 97Tuttle, L.M. 213Ulbrich, A. 25Ulevitch, R.J. 167Ullmann, M. 222Umezawa, T. 97Unger, V.M. 71Unwin, N. 69Uritboonthai, W. 231Usui, K. 95Utsintong, M. 225Utsumi, N. 240, 249Uusitalo-Jarvinen, H. 157Uzzell, V. 65Va, P. 102Valadon, P. 135Valdez, C. 104Valenta, D.T. 133Vallee, S. 138Van Anda, H. 17van den Berg, A. 139Van der Schans, E.J.C. 218van der Stap, L. 338

van Drogen, F. 255van Leeuwen, E.M.M. 161Vanderklish, P.W. 360, 363Vanhnasy, J.A. 190Vanitha John, D. 291Vareille, G. 225Vela, J. 151Velasquez, J. 203Venkataraman, S. 251Vente, P.A. 252Verdeil, G. 160Verdino, P. 190Vereyken, E. 334Versteeg, H. 157Vetter, S. 254Villena, J.A. 56Vogt, P.K. 304Vojkovsky, T. 353Von Allmen-Zurcher, N. 163von Herrath, M. 324von Lhneysen, K. 144Vossman, N. 47Voytek, S.B. 238Waalen, J. 299Waas, W. 234, 236Wahlestedt, C. 27Walker, B.M. 114, 332Walker, R.C. 220Wang, C. 163Wang, G.Z. 145Wang, H. 106Wang, J. 97, 103, 218, 306Wang, L. 203Wang, M. 70, 131Wang, S.-K. 107Wang, X. 104Wang, Y. 95, 98Want, E. 231Ward, A. 199Ware, J. 288Warrington, J. 290Watanabe, M. 141Watry, D. 325Webb, S. 63Webb, W. 231Weber, J.L. 335Weber, K.L. 52Wee, S. 114Weerapana, E. 49Wei, B. 49Wei, C.H. 160Wei, Y. 145Weide, T. 91, 104Weiler, H. 312Weinell, K.M. 158Weinkam, P. 100Weiss, F. 341Weiss, Y. 243Weissmann, C. 174Welsh, D.K. 22Wentworth, A.D. 106Wentworth, P., Jr. 106Westra, W. 265Wheeler, M.C. 23Wheeler, R. 223Whiby, L. 84White, R.A. 293Whitefield, B. 83Whitelock, J. 141Whiting, M. 91Whitley, K. 128Whitmire, J.K. 298, 331

Whitten-Bauer, C. 297Whitton, J.L. 322, 331Wieland, S.F. 296, 297Wiethoff, C. 153Wikoff, W. 231Wilkes, J.J. 23Williams, A. 102Williams, J. 258Williams, R.S. 197Williamson, J.R. 233Willis, A. 92Wills, D. 332Wilson, A. 293Wilson, C.A. 290Wilson, I.A. 131, 168, 190Wilson, R.F. 254Wiltshire, T. 288Winbush, S. 102Witherden, D.A. 141Witkowski, J.A. 291Wittenberg, C. 256Wohlschlegel, J. 255Wojciak, J. 208Wong, C. 70Wong, C.-H. 107, 291Wong, D. 231Wong, J. 160Wong, T. 135Wong, V. 220Woo, H.K. 231Wood, T.I. 195Woodward, E.L. 263Wright, P.E. 208, 211, 213Wu, B. 57, 203Wu, C.C. 139Wu, J. 60, 233Wu, T. 97Wu, W. 146Wu, X. 303Wthrich, K. 207Xia, F. 335Xia, Y. 128Xiang, R. 154, 168Xiao, B. 65Xiao, N. 128Xie, J. 84, 88Xie, W. 234, 236Xiong, W. 63, 87Xu, C.R. 135Xu, F. 44Xu, H. 97Xu, L. 190Xu, T. 70Xu, X. 190, 312, 314Xu, Y. 87, 92Yachi, P. 138Yadav, M. 57Yagi, T. 281Yamada, Y. 258Yamagaki, T. 211Yamagata, A. 197Yamaguchi, J. 83Yamaguchi, M. 200Yamashita, T. 281Yan, M. 306Yanes, O. 231Yang, C. 32Yang, G. 50Yang, J. 290Yang, Q.-K. 145Yang, X. 312Yang, X.-L. 234, 236

Yang, Y. 159Yang, Y.-Y. 107Yarar, D. 68Yasuda, M. 61Yates, J.R. III 70, 286, 290Ye, M. 144Ye, X. 265Ye, Y. 240Ye, Z. 307Yeager, M. 71, 322Yegneswaran, S. 312Yi, J. 308Yi, K.S. 240Yin, X. 306Ying, G. 326Yoneda, Y. 92Yonemoto, I. 45, 95Yoon, S.I. 190York-DeFalco, C. 325Yoshida, K. 163Yoshimoto, K. 223Yoshioka, C. 47, 322Yoshizuka, N. 261Young, B.M. 27Young, T. 103Yu, J. 199Yu, W. 100Yu, Z. 95Yuan, Y. 240Yung, Y. 265Zadorozhny, V. 163Zadory, D. 353, 372Zajonc, D.M. 190Zampolli, A. 284Zandonatti, M. 325Zeeb, M. 208Zeng, Y. 266Zhang, D.-E. 306Zhang, E. 22Zhang, F. 44Zhang, H. 97, 129, 240, 249Zhang, H.-Y. 27Zhang, J. 297Zhang, Q. 203, 225Zhang, W. 220, 234, 236,

302Zhang, Y. 84Zhao, J. 26Zhao, L. 304Zhao, Q. 57, 203Zhao, Y. 114, 119, 225, 341Zheng, M. 139Zhou, B. 92Zhou, H. 92, 154, 168Zhou, M. 175Zhou, Q. 234, 236Zhou, W. 361Zhu, J.-H. 145Zhu, L. 265Zhu, X. 87, 190Zimmermann, J. 100Zlokovic, B.V. 312Zoni, C. 98Zorrilla, E.P. 114, 119, 341Zou, W. 306Zuhl, A. 84Zuniga, E. 326Zwick, M.B. 131, 168


S U B J E C T I N D E X 2 0 0 7

Acetogenins 248Actin 50, 52, 68, 276Activated protein C 155, 312,

314Acute respiratory distress

syndrome 157Adaptive immunity 148, 152,

163, 192Addiction 114, 117, 119, 337,

341Adipogenesis 351Adjuvants 152Adoptive immunity 326Aging 26, 62, 96, 307, 308,

344AIDS. See HIV infection.Alcohol 114, 117, 337, 339,

342Alcohol dependence 116Alcohol. See also Ethanol.Alcoholism 332Algae 60Alzheimers disease 26, 56, 96,

106, 256, 308Ammonium transport 223Amphetamines 118Amygdala 120, 340Amyloid diseases 95, 307Amyloidogenesis 95Anandamide 49Anaphase-promoting complex 35Anemia 301Angiogenesis 66, 146, 157, 236,

289, 290Annexins 134, 277Anthrax 252, 293Anthrax toxins 130, 136Antibiotics 97Antibodies 190, 245

fluorescent 193phage display 241to HIV 131, 241to tumors 241to viruses 133

Antibody genes 135Antibody repertoire 135, 245Antibody-catalyzed water

oxidation pathway 106Anticancer agents 97Antisense therapy 323Antitumor antibiotics 84Anxiety 335, 343Apolipoprotein AI 133Apomyoglobin 211Apoptosis 32, 312Arthritis 276Aspergers syndrome 99Asthma 243Asymmetric synthesis 240Ataxia telangiectasialike disorder

303Atheronals 106Atherosclerosis 133Atherothrombosis 146Auditory perception 63Autism 98Autoimmunity 135, 163, 311,

332

antitumor 166genetics of 164inhibition of cell cycle in 166role of p21 and p27 166

Autophagy 32B cells 135

antigen recognition by 152immune learning in 151induction of memory 149regulation of function 149role of Rho guanine nucleotide

exchange factors 139Bacteria

pilus 198sporulation of 294

Base J DNA 107Binding sites 228Biocatalysis 237Biofilms 295Bioinformatics 229, 251Biological chemistry 103Biomolecular computing 243Biomolecular detection 246Bioorganic chemistry 84Biosensors 223Botulinum 204Botulinum neurotoxin 92Breast cancer 70, 145, 286, 302Caenorhabditis elegans 233Calcium channels 334Calcium signaling 61Calorie restriction 345Cancer 32, 57, 66, 93, 154,

157, 164, 217, 255, 259, 261, 286, 292, 304, 306

design of therapeutic antibodies241

Cancer therapy 247Cannabinoids 339Cannabis dependence 116Carcinogenesis 145Cardiac gap junctions 72Cartilage 276Catalysis 52, 89, 104Catalytic antibodies 94, 103,

193, 240, 247in transgenic plants 244

Cavitands 17Cell cycle 35

checkpoints 258, 259, 303control in mammalian cells 255control in yeast cells 255regulation of 256

Cell migration 50Chaperones 96, 213Chaperonins 207, 215Charcot-Marie-Tooth disease 235Chemical biology 97Chemical ligations 52Chemical synthesis 97Chemobodies 242Chemokine receptors 292Chemokines 334Chlamydial infections 145Chloroplasts 60Chondrocytes 276Chondrogenesis 276Chromatin 352Chromosome segregation 50

Chronic wasting disease 328Circadian clocks 22, 195Circadian oscillators 23Clathrin 68Click chemistry 104Cloning 47Coagulation 134, 147, 155,

157, 312314Cocaine 342Cognition 61Combinatorial chemistry 87, 103Combinatorial libraries 247Complex I defects 282Computer modeling

of proteins and nucleic acids 220

Conformational diseases 45Consortium for Functional

Glycomics 267Coreceptor switching 150Creutzfelt-Jakob disease 178Cyclic peptides 93Cyclins 255Cycloadditions 91, 105Cyclophilins 137Cystic fibrosis 46Cytochrome ba3 201, 223Cytochrome c oxidases 201Cytochrome oxidases 200Cytochrome P450s 201, 278Cytokines 164, 236, 302, 345

control of expression 150in T-cell homeostasis 161in viral clearance 326

Cytoskeleton 50, 52, 129, 136Cytotoxic stress responses 258Deafness 64Demyelination 324Dendrites 363Dendritic cells 149, 326Dendritic spines 55Dengue fever 159Depression 262, 264, 335, 343

genetics of 27Despair 262Diabetes 23, 26, 67, 70, 142,

160, 163, 280, 286Diels-Alder reactions 84Differential gel analysis 309Directed evolution 238, 240Disease models 372DNA

in antiviral signaling 297DNA damage 101, 258, 259DNA enzymes 219DNA repair 198, 258, 260DNA replication 303DNA transcription

regulation of 44DNA-agent interactions 85Docking 226Drug abuse 94, 118, 337

mechanisms of 120, 340Drug addiction 353Drug dependence 114, 338Drug discovery 28, 370

computer aided 229Drug metabolism 369Drug repurposing 230

Dynamin 68Ecstasy 118Electron cryomicroscopy 71Electrostatics 222Emerging viruses 133Encapsulation 17Encephalitis 324Endocannabinoids 117Endocytosis

regulation of 68Endothelial cells 135, 155Endotoxin 167

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