A review of human carcinogens—volume 100 Part A: Pharmaceuticals

Hormonal treatments assessed by the IARC Monograph Working Group, Vol. 100, 2009

The Lancet Oncology, volume 10, 13-14, January 2009

A review of human carcinogens—Vol. 100 - Part A: Pharmaceuticals

Antineoplastic drugs, and other drugs evaluated by the IARC Monograph Working GroupVol. 100, 2009

The Lancet Oncology, volume 10, 13-14, January 2009

A review of human carcinogens—volume 100 Part B: Biological Agents

Biological agents assessed by the IARC Monograph Working Group - Vol. 100, 2009

The Lancet Oncology, volume10, 321-322, April2009

A review of human carcinogens—volume 100 Part B: Biological Agents

Biological agents assessed by the IARC Monograph Working Group - Vol. 100, 2009

The Lancet Oncology, volume10, 321-322, April2009

A review of human carcinogens—volume 100 Part C: Metals, arsenic, dusts, and fibres

Metals, arsenic, dusts, and fibres assessed by the IARC Monograph Working Group Vol. 100, 2009

The Lancet Oncology, volume10, 453-454, May 2009

ASBESTO: Crisotilo, Amosite, Crocidolite, Tremolite, Actinolite, Antofillite

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. A Review of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts. Vol.100 C , 2011.

• There is sufficient evidence in humans for the carcinogenicity of all forms of asbestos.

EVALUATION

– Asbestos causes mesothelioma and cancer of the lung, larynx, and ovary [sufficiente].

• There is sufficient evidence in experimental animals for the carcinogenicity of all forms of asbestos.

PA Bertazzi, UNIMI

– Also positive associations have been observed between exposure to all forms of asbestos and cancer of the pharynx, stomach, and colo-rectum [limitato].

Camargo C.M. et al. Env Hlth Perspect. 2011

Esposizione occupazionale ad amianto e tumore ovarico

PA Bertazzi, UNIMI

Camargo C.M. et al. Env Health Perspect. 2011

Esposizione occupazionale ad amianto e tumore ovaricoAnalisi dei sei studi su alta esposizione

PA Bertazzi, UNIMI

Laringe • The IOM conducted a meta-analysis of cohort studies examining

the association between asbestos exposure and cancer of the larynx. For studies examining “any” versus no exposure, the summary relative risk was 1.4 (95%CI: 1.19–1.64).For studies comparing “high” versus no exposure, the lower bound summary relative risk was 2.02 (95%CI: 1.64–2.47), and the upper bound summary relative risk was 2.57 (95%CI:1.47–4.49).

• The IOM also conducted a meta-analysis of the published case–control studies examining the association between asbestos exposure and cancer of the larynx (IOM, 2006). This meta-analysis calculated a summary relative risk of 1.43 (95%CI: 1.15–1.78), before adjusting for consumption of tobacco and alcohol. After adjusting for tobacco and alcohol consumption, the association of cancer of the larynx with asbestos exposure persisted, with an adjusted summary relative risk of 1.18 (95%CI: 1.01–1.37).

PA Bertazzi, UNIMI

ASBESTO: Crisotilo, Amosite, Crocidolite, Tremolite, Actinolite, Antofillite

All forms of asbestos are carcinogenic to humans (Group 1).Talc containing asbestiform fibres is carcinogenic to humans (Group 1)

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. A Review of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts. Vol.100 C , 2011.

• There is sufficient evidence in humans for the carcinogenicity of all forms of asbestos.

EVALUATION

– Asbestos causes mesothelioma and cancer of the lung, larynx, and ovary [sufficiente].

– Also positive associations have been observed between exposure to all forms of asbestos and cancer of the pharynx, stomach, and colo-rectum [limitato].

• There is sufficient evidence in experimental animals for the carcinogenicity of all forms of asbestos.

PA Bertazzi, UNIMI

IARC Monographs Vol. 100 C, 2012

Esposizione occupazionale ad amianto e cancro colo-rettale

RR per le categorie di esposizione più alta a confronto con i non esposti

PA Bertazzi, UNIMI

Malattie per le quali Denuncia è Obbligatoria Lista 1- Elevata probabilità di origine lavorativa-Gruppo 6:

– MM in sede pleurica, pericardica, peritoneale e della tunica vaginale del testicolo per esposizione ad ‘asbesto’

– MM pleurico per esposizione ad ‘erionite’.Inoltre

– MM pleurico per esposizione a ‘talco contenente fibre asbestiformi.’

Lista 2 - Limitata probabilità di origine lavorativa - Gruppo 6– Tumore laringeo per esposizione ad ‘asbesto’

Lista 3 - Possibile origine lavorativa - Gruppo 6– Tumori gastroenterici per esposizione ad ‘asbesto’

Inoltre– Mesotelioma pleurico per esposizione a ‘fibre ceramiche’

MINISTERO DEL LAVORO E DELLA PREVIDENZA SOCIALE - DECRETO 14 gennaio 2008Elenco delle malattie per le quali è obbligatoria la denuncia ai sensi e per gli effetti dell'articolo 139 del testo

unico approvato con decreto del Presidente della Repubblica 30 giugno 1965, n. 1124, e successive modificazioni e integrazioni

SUPPLEMENTO ORDINARIO ALLA GAZZETTA UFFICIALE SERIE GENERALE N. 70 22.3.2008

PA Bertazzi, UNIMI

Nuova Tabella Malattie Professionali

Figurano nella Nuova Tabella delle Malattie Professionali nell’Industria: – MM insorto in sede pleurica, pericardica, peritoneale e della

tunica vaginale del testicolo a causa di ‘Lavorazioni che espongano all’azione di fibre di asbesto’

– MM pleurico e peritoneale insorto a causa di ‘Estrazione e utilizzazione di erionite’.

MINISTERO DEL LAVORO E DELLA PREVIDENZA SOCIALE - DECRETO 14 Gennaio 2008Nuove Tabelle delle Malattie professionali nell’Idustria e nell’Agricoltura

SUPPLEMENTO ORDINARIO ALLA GAZZETTA UFFICIALE SERIE GENERALE N. 169 21.7.2008

PA Bertazzi, UNIMI

A review of human carcinogens—volume 100 Part D: Radiation

Chemical agents and related occupations assessed by the IARC Monograph Working Group Vol. 100, 2009

The Lancet Oncology,vol.10, 751-752, August 2009

A review of human carcinogens—volume 100 Part E: Lifestyle factors

Chemical agents and related occupations assessed by the IARC Monograph Working Group Vol. 100, 2009

The Lancet Oncology,vol.10, 1033-1034, November 2009

• Aflatoxins, • 4-Aminobiphenyl, • Benzene, • Benzidine,• Dyes metabolized to benzidine, • Bis(chloromethyl)ether & chloromethyl

methyl ether (technical grade), • 1,3-Butadiene, • Ethylene oxide, • Formaldehyde, • 4,4 -methylenebis(2-chloroaniline), ′• Mustard gas, • 2-Naphthylamine, • 2,3,7,8-TCDD, • 2,3,4,7,8-PeCDF, • PCB 126, • o-Toluidine, • Vinyl chloride, • Benzo[a]pyrene,

• Soot, as found in occupational exposure of chimney-sweeps,

• Coal gasification, • Occupational exposures during coal-tar

distillation, • Coke production, • Coal-tar pitch, • Untreated or mildly treated mineral oils, • Shale oils • Occupational exposures during aluminum

production, • Auramine production, • Occupational exposures during iron and steel

founding, • Isopropyl alcohol manufacture by the strong-

acid process, • Magenta production, Occupational exposure

as a painter, • Occupational exposures in the rubber

manufacturing industry, • Mists from strong inorganic acids were found

to be carcinogenic to humans (Group1).

Auramine and magenta were found to be possibly carcinogenic to humans (Group 2B).

A review of human carcinogens—volume 100 Part F:Chemical agents and related occupations

Chemical agents and related occupations assessed by the IARC Monograph Working Group Vol. 100, 2009

A review of human carcinogens—volume 100 Part F: Chemical agents and related occupations

Chemical agents and related occupations assessed by the IARC Monograph Working Group Vol. 100, 2009

A review of human carcinogens - Part F: Chemical agents and related occupations

• Formaldehyde was confirmed as carcinogenic to humans. There is sufficient evidence in humans of an increased incidence of nasopharyngeal carcinomas. In addition, the epidemiological evidence on leukemia has become stronger, and new mechanistic studies support a conclusion of sufficient evidence in humans. This highlights the value of mechanistic studies, which in only 5 years have replaced previous assertions of biological implausibility with new evidence that formaldehyde can cause blood-cell abnormalities that are characteristic of leukemia development.

• Occupational exposure as a painter causes cancers of the lung, urinary bladder and pleural mesothelioma in humans. Due to the diversity and complexity of the exposures, it is difficult to identify causal agents or a causal mechanism, although there is strong evidence that the exposures are genotoxic. The Working Group found limited evidence of an association between maternal exposure to painting before and during pregnancy and an increased risk of childhood leukemia in the offspring. These findings confirm those of a previous Working Group (2007).

IARC Monograph Working Group Vol. 101, 2011

The Lancet Oncology, Volume 12, 328-329, April 2011