KYORITSU SEIYAKU CORPORATIONCORPORATE PROFILE

KYORITSU SEIYAKU CORPORATIONCORPORATE PROFILE

Established: May, 1955

ActivitiesProduction, Distribution,

Import and Export of Animal Health Products

Sales Turnover (Actual Sales from June. 2015 to May 2016)

JPY 41 billionUSD 373 million (USD 1= JPY 110)EUR 328 million (EUR 1= JPY 125)

Employees548 : Kyoritsu Seiyaku Corporation

1,313: Total KS Group (Oct. 31,2016)

RepresentativeTakaaki Takai, President

Headquarters1-11-5 Kudan-kita, Chiyoda-ku, Tokyo, Japan

395

413

442

475

523

7

7

7

3

3

108

116

121

127

134

0 100 200 300 400 500 600 700

2012

2013

2014

2015

2016

100 million JPY

Fiscal Year

Animal Health

Human Health

Emvironmental Hygiene

KS Group Annual Sales

Strength of ProductionExtensive portfolio of products: including biological products (vaccines), pharmaceuticals, feed additives, in feed and other medical devices.Three manufacturing sites: specialised by dosage formEffective production of small-volume medicinesAdvanced technology to ensure high quality, reliable supply

Companion Animal Product Range

Others: Nutraceutical products, Diagnostic kit, Royal Canin Veterinary Diet, Care tool

Production Animal Product Range

Bovivac 5 (IBR+BVD Ia&II+PI3+BRSV)Bovivac B5 (IBR+BVD Ib&II+PI3+BRSV)Swivac BPE (AR+ Pasturella+Recombinant SE)Swivac ERA(Recombinant SE)Suvaxyn Aujeszky (AD)

Fel-O-Vax3 (RCP)Anti Inflammatory

Sulfonamide

Poultry Vaccine

Antimicrobial

Diagnostic Kit / Medium

Bovine/Swine Vaccine

Salmonella Trivalent(SE+ST+SI, Inactivated)Poulvac MDcviPoulvac IB H120Poulvac COMBI (ND+IB)LT-VAX (ILT)Avivac BD(Gumboro)

JOHNELISA Ⅱ(M. paratub. ELISA)JOHNELISA Screening KSJohne First (Extraction Kit)Mycobactin Herrold’s Egg Yolk medium with MycobactinMycolisa MH (M. Hyo. ELISA)

Florfenicol (Premix, Inj.)Cefazolin (Inj.)Amoxicillin (Water Soluble)Mycillin Sol (PC / SM Inj.)CTC-S20FColistin 10 and others

Trioprin inj. (Sulfadoxin / TMP)S T powder (Sulfamethoxasol)

Metacam(Meloxicam)Sulpirin (Salicylic Acid, etc)Andress ointmentDexamethasone Injection “KMK” Prednisolone Injection “KMK”

Adrestan, Dorbene, Atipame, Delvosteron,

PimobeHeart, Ofloxacin

IntercatInterdog

M

My Flea Guard My Flea Guard α

MoxiHeart Tab KS

Medicines

Interferon

Flea & Tick Preventative

Heartworm Preventative

Canivac KC-3Canivac 5

Rabies TC Vaccine

Canine /Feline Vaccine

Production Animal Product Range 2 Aquaculture Product Range

Fel-O-Vax3 (RCP)Anti Metabolic

Mastitis

Digestive

Hormone

Anthelmintic

Estomal/Receptal (GnRH)Dalmazin(PGF2α)Spornen (GnRH)Antrin R(FSH)Gestoron (HCG)Ovapron V (Progesteron, IVD)Poston (Oxytocin)Serarumon (PMS)

Dicloxa syringe/jet/ointment SP ointment syringe (PC/SM)Neopenitube (NM/PC)Kayaten (NF)Cefazolin (CEZ)

Takaberine (Berberine) Geritomin powder (Berberine)Gastoline (Menthol)

Asedist Fine Granules (Bromophos)Noromectin (Ivermectin)Levamisole powder

E-S-E (Vitamin E / Selen) Vita Long Forte (AD3E)Electroplus A (Electrolyte)Neorunogen (Propylene Glycol)Iron 100/200 (Dextran)Newglon (Ca)Ketoplex inj (Propionic Acid)

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PISCIVAC LVPR/Oil(Lacto / Vibrio / Irido / Photobactinj. for yellowtail)

PISCIVAC LVS( Lacto / Vibrio / Strepto inj. for

amberjack)

PISCIVAC Three ways( Lacto / Vibrio / Irido inj. for yellowtail & amberjack)

PISCIVAC Vibrio + Rensa(Lacto / Vibrio inj. for yellowtail)

PISCIVAC Vibrio (Immersion use for salmonids)

Fish Vaccine

PISCIVAC

M-Vac Iniae(Streptococcus iniae for flounder fish)M-VAC Rensa(Lacto inj. for yellowtail)M-VAC S.I.P 3(S. iniae / S. Parauberis I & II for flounder fish )

Fish Vaccine

M-Vac

Feed / Premix

Ursodeoxycholic acidGlutathione powderNifurstylenate powderLincomycin powderOTC powderOxolinic acid powderErythromycin powderAmpicillin powder

Tsukuba Factory

Tsukuba factory manufactures biological products (vaccines), di-agnostic drugs, medium additives for bacteria and hormones. Our vaccines are targeted at poultry, swine, bovine and aquaculture. They are manufactured as freeze-dried, liquid and frozen with 3 production lines.

Established 1967Location Tsukuba-shi, Ibaraki-kenSite Area 29,419 square metresEmployees 72Number of products Vaccines 59

Hormones 18Diagnostic Drugs, medium additives etc 38

Global Supply Partners

JAPAN-Elanco Animal Health-Suntory-ASKA Pharmaceutical-Toray Industries-Idemitsu Kosan -Matsuken Pharmaceutical Industry-Adtec Company-PVG Japan -PIC BIO

ASIAKOREA -YuhanTAIWAN -Institute for Microbial ResourcesVIETNAM -Navetco

EUROPEUK -Dechra Pharmaceuticals-NorbrookITALY -Fatro-Agrolabo HOLLAND -Akzo NobelFRANCE -Royal Canin -Vétoquinol SPAIN -Hipra -SyvaFINLAND -Vetcare

NORTH AMERICAUSA-Zoetis-Pet-Ag-Milk Specialties-Addison Biological Laboratory-Animal Health Options-Vétoquinol USASouth AmericaArgentina-Syntex

Current Top 15 Animal Health Companies in the World

Ranking Company 2016 sales (million USD)Change

(%)

1 Zoetis (US) 4,888 +3

2 Merck/MSD Animal Health (US) 3,478 +4

3 Elanco (US) 3,158 -1

4 Merial (US) 2,997 +8

5 Bayer Animal Health (Germany) 1,685 +2

6 IDEXX Laboratories (US) 1,649 +11

7 Boehringer Ingelheim Animal Health (Germany) 1,616 +7

8 Ceva Sante Animale (France) 1,009 +6

9 Virbac (France) 965 +2

10 Phibro Animal Health (US) 703 +1

11 Kyoritsu Seiyaku (Japan) 434 +6

12 Huvepharma (Bulgaria) 420 +28

13 Vetoquinol (France) 388 +2

14 Dechra Pharmaceuticals (UK) 368 +22

15 Norbrook Laboratories (UK) 350 +11

Top 10 Animal Health Companies in Japan for FY 2014

Animal Health CompanyTotal PA

CA (Pharmaceuticals+Neutraceuticals)

140,828 100.0% 65,163 100.0% 75,665 100.0%

1 Kyoritsu Seiyaku Corporation 40,727 28.9% 9,294 14.3% 31,433 41.5%

2 ZENOAQ 16,523 11.7% 7,322 11.2% 9,201 12.2%

3 DS Pharma 13,913 9.9% 1,025 1.6% 12,888 17.0%

4 Zoetis 9,739 6.9% 4,542 7.0% 5,197 6.9%

5 Intervet 8,644 6.1% 6,748 10.4% 1,896 2.5%

6 Kyoto Biken Laboratories 6,810 4.8% 5,223 8.0% 1,587 2.1%

7 Meiji Seika Pharma 6,744 4.8% 5,639 8.7% 1,105 1.5%

8 Boehringer Ingelheim 6,009 4.3% 4,421 6.8% 1,588 2.1%

9 Novartis Animal Health 5,222 3.7% 935 1.4% 4,287 5.7%

10 Bayer Health Care 4,953 3.5% 3,557 5.5% 1,396 1.8%

PA: Production Animals CA: Companion Animals

Unit: Million JPY; Ex- Wholesaler

Source:Animal Pharm May 10, 2017c