KUTNER BLOOD PRESSURE DATA -- UNBALANCED DESIGN … · kutner blood pressure data -- unbalanced...

KUTNER BLOOD PRESSURE DATA -- UNBALANCED DESIGN 1

BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGE08:01 Monday, April 19, 2004

Obs DRUG DISEASE ISBP MISS BSBP FSBP

1 1 1 42 0 142 184

2 1 1 44 0 136 180

3 1 1 36 0 118 154

4 1 1 13 0 114 127

5 1 1 19 0 107 126

6 1 1 22 0 116 138

7 1 2 33 0 125 158

8 1 2 26 0 115 141

9 1 2 33 0 132 165

10 1 2 21 0 115 136

11 1 3 31 0 119 150

12 1 3 -3 0 92 89

13 1 3 25 0 121 146

14 1 3 25 0 117 142

15 1 3 24 0 111 135

16 2 1 28 0 109 137

17 2 1 23 0 116 139

18 2 1 34 0 126 160

19 2 1 42 0 139 181

20 2 1 13 0 112 125

21 2 2 34 0 116 150

22 2 2 33 0 134 167

23 2 2 31 0 127 158

24 2 2 36 0 119 155

25 2 3 3 0 76 79

26 2 3 26 0 98 124

27 2 3 28 0 118 146

28 2 3 32 0 115 147

29 2 3 4 0 100 104

30 2 3 16 0 97 113

31 3 1 1 0 95 96

32 3 1 29 0 102 131

33 3 1 19 0 114 133

34 3 2 11 0 104 115

35 3 2 9 0 115 124

36 3 2 7 0 126 133

37 3 2 1 0 104 105


BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGE08:01 Monday, April 19, 2004

Obs DRUG DISEASE ISBP MISS BSBP FSBP

38 3 2 -6 0 97 91

39 3 3 21 0 125 146

40 3 3 1 0 107 108

41 3 3 9 0 99 108

42 3 3 3 0 109 112

43 4 1 24 0 121 145

44 4 1 9 0 95 104

45 4 1 22 0 99 121

46 4 1 -2 0 104 102

47 4 1 15 0 107 122

48 4 2 27 0 113 140

49 4 2 12 0 117 129

50 4 2 12 0 82 94

51 4 2 -5 0 96 91

52 4 2 16 0 89 105

53 4 2 15 0 107 122

54 4 3 22 0 105 127

55 4 3 7 0 83 90

56 4 3 25 0 121 146

57 4 3 5 0 101 106

58 4 3 12 0 92 104


BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEDRUG EFFECT ON FOLLOWUP B.P., UNADJUSTED

08:01 Monday, April 19, 2004

The GLM Procedure

Class LevelInformation

Class Levels Values

DRUG 4 1 2 3 4

Number of observations 58



08:01 Monday, April 19, 2004

The GLM Procedure

Dependent Variable: FSBP

Source DFSum of

Squares Mean Square F Value Pr > F

Model 3 9895.46897 3298.48966 6.98 0.0005

Error 54 25502.60000 472.27037

Corrected Total 57 35398.06897

R-Square Coeff Var Root MSE FSBP Mean

0.279548 16.79248 21.73178 129.4138

Source DF Type III SS Mean Square F Value Pr > F

DRUG 3 9895.468966 3298.489655 6.98 0.0005

Parameter EstimateStandard

Error t Value Pr > |t|

Intercept 115.5000000 B 5.43294562 21.26 <.0001

DRUG 1 29.2333333 B 7.81035143 3.74 0.0004

DRUG 2 23.5000000 B 7.81035143 3.01 0.0040

DRUG 3 1.3333333 B 8.29896152 0.16 0.8730

DRUG 4 0.0000000 B . . .

NOTE: The X'X matrix has been found to be singular, and a generalized inverse was used to solve the normal equations. Terms whoseestimates are followed by the letter 'B' are not uniquely estimable.



08:01 Monday, April 19, 2004

The GLM ProcedureLeast Squares Means

DRUG FSBP LSMEANStandard

Error Pr > |t|LSMEAN

Number

1 144.733333 5.611122 <.0001 1

2 139.000000 5.611122 <.0001 2

3 116.833333 6.273425 <.0001 3

4 115.500000 5.432946 <.0001 4

Least Squares Means for effect DRUGPr > |t| for H0: LSMean(i)=LSMean(j)


i/j 1 2 3 4

1 0.4731 0.0016 0.0004

2 0.4731 0.0110 0.0040

3 0.0016 0.0110 0.8730

4 0.0004 0.0040 0.8730

NOTE: To ensure overall protection level, only probabilities associated with pre-planned comparisons should be used.


BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEREGRESSION OF FOLLOWUP ON BASELINE 08:01 Monday, April 19, 2004

The GLM Procedure



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEREGRESSION OF FOLLOWUP ON BASELINE 08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 1 30786.10565 30786.10565 373.82 <.0001

Error 56 4611.96332 82.35649



0.869711 7.012427 9.075048 129.4138

Source DF Type I SS Mean Square F Value Pr > F

BSBP 1 30786.10565 30786.10565 373.82 <.0001


BSBP 1 30786.10565 30786.10565 373.82 <.0001



Intercept -52.35507204 9.47658426 -5.52 <.0001

BSBP 1.64445394 0.08505371 19.33 <.0001


BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEDRUG EFFECT ON Baseline B.P. 08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4




The GLM Procedure

Dependent Variable: BSBP

Source DFSum of


Model 3 2358.44770 786.14923 4.70 0.0055

Error 54 9025.98333 167.14784


R-Square Coeff Var Root MSE BSBP Mean

0.207164 11.69641 12.92857 110.5345


DRUG 3 2358.447701 786.149234 4.70 0.0055



Intercept 102.0000000 B 3.23214170 31.56 <.0001

DRUG 1 16.6666667 B 4.64649645 3.59 0.0007

DRUG 2 11.4666667 B 4.64649645 2.47 0.0168

DRUG 3 6.0833333 B 4.93717800 1.23 0.2232

DRUG 4 0.0000000 B . . .





DRUG BSBP LSMEANStandard


Number

1 118.666667 3.338142 <.0001 1

2 113.466667 3.338142 <.0001 2

3 108.083333 3.732156 <.0001 3

4 102.000000 3.232142 <.0001 4



i/j 1 2 3 4

1 0.2756 0.0392 0.0007

2 0.2756 0.2871 0.0168

3 0.0392 0.2871 0.2232

4 0.0007 0.0168 0.2232



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEDRUG EFFECT ON FOLLOWUP B.P., ADJUSTED FOR BASELINE B.P.

08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4




08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 4 32112.35031 8028.08758 129.50 <.0001

Error 53 3285.71866 61.99469



0.907178 6.084105 7.873671 129.4138


DRUG 3 1326.24466 442.08155 7.13 0.0004

BSBP 1 22216.88134 22216.88134 358.37 <.0001



Intercept -44.52743930 B 8.67952910 -5.13 <.0001

DRUG 1 3.08505894 B 3.14889757 0.98 0.3317

DRUG 2 5.50998722 B 2.98508703 1.85 0.0705

DRUG 3 -8.21078682 B 3.04878232 -2.69 0.0095

DRUG 4 0.00000000 B . . .

BSBP 1.56889646 0.08287623 18.93 <.0001




08:01 Monday, April 19, 2004


Coefficients for DRUG Least Square Means

DRUG Level

Effect 1 2 3 4

Intercept 1 1 1 1

DRUG 1 1 0 0 0

DRUG 2 0 1 0 0

DRUG 3 0 0 1 0

DRUG 4 0 0 0 1

BSBP 110.534483 110.534483 110.534483 110.534483



Number

1 131.974779 2.141777 <.0001 1

2 134.399707 2.047445 <.0001 2

3 120.678933 2.281993 <.0001 3

4 128.889720 2.091638 <.0001 4



i/j 1 2 3 4

1 0.4080 0.0008 0.3317

2 0.4080 <.0001 0.0705

3 0.0008 <.0001 0.0095

4 0.3317 0.0705 0.0095



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEDRUG BY DISEASE EFFECTS ON FOLLOWUP B.P., UNADJUSTED

08:01 Monday, April 19, 2004

The GLM Procedure

Class Level Information

Class Levels Values

DRUG 4 1 2 3 4

DISEASE 3 1 2 3




08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 11 15468.63563 1406.23960 3.25 0.0024

Error 46 19929.43333 433.24855



0.436991 16.08378 20.81462 129.4138


DRUG 3 10191.88576 3397.29525 7.84 0.0002

DISEASE 2 2181.69748 1090.84874 2.52 0.0917

DRUG*DISEASE 6 3018.68300 503.11383 1.16 0.3434



Intercept 114.6000000 B 9.30858261 12.31 <.0001

DRUG 1 17.8000000 B 13.16432377 1.35 0.1829

DRUG 2 4.2333333 B 12.60388043 0.34 0.7385

DRUG 3 3.9000000 B 13.96287391 0.28 0.7813

DRUG 4 0.0000000 B . . .

DISEASE 1 4.2000000 B 13.16432377 0.32 0.7511

DISEASE 2 -1.1000000 B 12.60388043 -0.09 0.9308

DISEASE 3 0.0000000 B . . .

DRUG*DISEASE 1 1 14.9000000 B 18.22518099 0.82 0.4178

DRUG*DISEASE 1 2 18.7000000 B 18.81009436 0.99 0.3254

DRUG*DISEASE 1 3 0.0000000 B . . .

DRUG*DISEASE 2 1 25.3666667 B 18.22518099 1.39 0.1707

DRUG*DISEASE 2 2 39.7666667 B 18.42221570 2.16 0.0361

DRUG*DISEASE 2 3 0.0000000 B . . .

DRUG*DISEASE 3 1 -2.7000000 B 20.64043947 -0.13 0.8965

DRUG*DISEASE 3 2 -3.8000000 B 18.81009436 -0.20 0.8408

DRUG*DISEASE 3 3 0.0000000 B . . .

DRUG*DISEASE 4 1 0.0000000 B . . .



08:01 Monday, April 19, 2004

The GLM ProcedureDependent Variable: FSBP



DRUG*DISEASE 4 2 0.0000000 B . . .

DRUG*DISEASE 4 3 0.0000000 B . . .




08:01 Monday, April 19, 2004




Number

1 144.633333 5.448445 <.0001 1

2 141.577778 5.448445 <.0001 2

3 117.366667 6.140739 <.0001 3

4 115.633333 5.222893 <.0001 4



i/j 1 2 3 4

1 0.6935 0.0018 0.0004

2 0.6935 0.0050 0.0013

3 0.0018 0.0050 0.8307

4 0.0004 0.0013 0.8307


DISEASE FSBP LSMEANStandard


Number

1 134.675000 4.936621 <.0001 1

2 133.650000 4.844340 <.0001 2

3 121.083333 4.702524 <.0001 3

Least Squares Means for effect DISEASEPr > |t| for H0: LSMean(i)=LSMean(j)


i/j 1 2 3

1 0.8828 0.0522

2 0.8828 0.0691

3 0.0522 0.0691




08:01 Monday, April 19, 2004


DRUG DISEASE FSBP LSMEANStandard


Number

1 1 151.500000 8.497534 <.0001 1

1 2 150.000000 10.407312 <.0001 2

1 3 132.400000 9.308583 <.0001 3

2 1 148.400000 9.308583 <.0001 4

2 2 157.500000 10.407312 <.0001 5

2 3 118.833333 8.497534 <.0001 6

3 1 120.000000 12.017328 <.0001 7

3 2 113.600000 9.308583 <.0001 8

3 3 118.500000 10.407312 <.0001 9

4 1 118.800000 9.308583 <.0001 10

4 2 113.500000 8.497534 <.0001 11

4 3 114.600000 9.308583 <.0001 12

Least Squares Means for effect DRUG*DISEASEPr > |t| for H0: LSMean(i)=LSMean(j)


i/j 1 2 3 4 5 6 7 8 9 10 11 12

1 0.9116 0.1365 0.8068 0.6573 0.0092 0.0377 0.0043 0.0179 0.0127 0.0028 0.0053

2 0.9116 0.2139 0.9093 0.6128 0.0249 0.0655 0.0123 0.0377 0.0304 0.0093 0.0147

3 0.1365 0.2139 0.2304 0.0788 0.2874 0.4189 0.1600 0.3247 0.3070 0.1406 0.1829

4 0.8068 0.9093 0.2304 0.5178 0.0234 0.0681 0.0112 0.0376 0.0294 0.0081 0.0136

5 0.6573 0.6128 0.0788 0.5178 0.0061 0.0226 0.0029 0.0110 0.0080 0.0020 0.0036

6 0.0092 0.0249 0.2874 0.0234 0.0061 0.9372 0.6799 0.9803 0.9979 0.6593 0.7385

7 0.0377 0.0655 0.4189 0.0681 0.0226 0.9372 0.6757 0.9252 0.9374 0.6608 0.7240

8 0.0043 0.0123 0.1600 0.0112 0.0029 0.6799 0.6757 0.7272 0.6947 0.9937 0.9398

9 0.0179 0.0377 0.3247 0.0376 0.0110 0.9803 0.9252 0.7272 0.9830 0.7115 0.7813

10 0.0127 0.0304 0.3070 0.0294 0.0080 0.9979 0.9374 0.6947 0.9830 0.6761 0.7511

11 0.0028 0.0093 0.1406 0.0081 0.0020 0.6593 0.6608 0.9937 0.7115 0.6761 0.9308

12 0.0053 0.0147 0.1829 0.0136 0.0036 0.7385 0.7240 0.9398 0.7813 0.7511 0.9308



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEDRUG BY DISEASE DIFFERENCES IN BASELINE B.P.

08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4

DISEASE 3 1 2 3




08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 11 4513.51437 410.31949 2.75 0.0081

Error 46 6870.91667 149.36775


R-Square Coeff Var Root MSE BSBP Mean

0.396464 11.05683 12.22161 110.5345


DRUG 3 2478.198048 826.066016 5.53 0.0025

DISEASE 2 749.163007 374.581504 2.51 0.0925

DRUG*DISEASE 6 1218.234164 203.039027 1.36 0.2511



08:01 Monday, April 19, 2004


DRUG BSBP LSMEANStandard


Number

1 118.638889 3.199134 <.0001 1

2 115.022222 3.199134 <.0001 2

3 107.622222 3.605624 <.0001 3

4 102.088889 3.066698 <.0001 4



i/j 1 2 3 4

1 0.4282 0.0269 0.0005

2 0.4282 0.1316 0.0054

3 0.0269 0.1316 0.2484

4 0.0005 0.0054 0.2484


DISEASE BSBP LSMEANStandard


Number

1 112.858333 2.898609 <.0001 1

2 113.904167 2.844425 <.0001 2

3 105.766667 2.761155 <.0001 3



i/j 1 2 3

1 0.7979 0.0831

2 0.7979 0.0458

3 0.0831 0.0458




08:01 Monday, April 19, 2004


DRUG DISEASE BSBP LSMEANStandard


Number

1 1 122.166667 4.989451 <.0001 1

1 2 121.750000 6.110805 <.0001 2

1 3 112.000000 5.465670 <.0001 3

2 1 120.400000 5.465670 <.0001 4

2 2 124.000000 6.110805 <.0001 5

2 3 100.666667 4.989451 <.0001 6

3 1 103.666667 7.056150 <.0001 7

3 2 109.200000 5.465670 <.0001 8

3 3 110.000000 6.110805 <.0001 9

4 1 105.200000 5.465670 <.0001 10

4 2 100.666667 4.989451 <.0001 11

4 3 100.400000 5.465670 <.0001 12



i/j 1 2 3 4 5 6 7 8 9 10 11 12

1 0.9581 0.1762 0.8124 0.8173 0.0038 0.0376 0.0864 0.1299 0.0265 0.0038 0.0051

2 0.9581 0.2404 0.8699 0.7958 0.0104 0.0589 0.1327 0.1806 0.0494 0.0104 0.0124

3 0.1762 0.2404 0.2828 0.1501 0.1325 0.3554 0.7188 0.8084 0.3836 0.1325 0.1403

4 0.8124 0.8699 0.2828 0.6626 0.0105 0.0672 0.1541 0.2110 0.0553 0.0105 0.0129

5 0.8173 0.7958 0.1501 0.6626 0.0049 0.0345 0.0776 0.1121 0.0265 0.0049 0.0060

6 0.0038 0.0104 0.1325 0.0105 0.0049 0.7301 0.2548 0.2429 0.5432 1.0000 0.9714

7 0.0376 0.0589 0.3554 0.0672 0.0345 0.7301 0.5383 0.5009 0.8644 0.7301 0.7160

8 0.0864 0.1327 0.7188 0.1541 0.0776 0.2548 0.5383 0.9227 0.6073 0.2548 0.2608

9 0.1299 0.1806 0.8084 0.2110 0.1121 0.2429 0.5009 0.9227 0.5611 0.2429 0.2477

10 0.0265 0.0494 0.3836 0.0553 0.0265 0.5432 0.8644 0.6073 0.5611 0.5432 0.5377

11 0.0038 0.0104 0.1325 0.0105 0.0049 1.0000 0.7301 0.2548 0.2429 0.5432 0.9714

12 0.0051 0.0124 0.1403 0.0129 0.0060 0.9714 0.7160 0.2608 0.2477 0.5377 0.9714



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEDRUG BY DISEASE EFFECTS ON FOLLOWUP B.P., ADJUSTED FOR BSBP

08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4

DISEASE 3 1 2 3




08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 12 32632.94394 2719.41200 44.26 <.0001

Error 45 2765.12502 61.44722



0.921885 6.057181 7.838828 129.4138


DRUG 3 1004.31971 334.77324 5.45 0.0028

DISEASE 2 77.44095 38.72047 0.63 0.5371

DRUG*DISEASE 6 480.01760 80.00293 1.30 0.2759

BSBP 1 17164.30831 17164.30831 279.33 <.0001



Intercept -44.08633346 B 10.12112729 -4.36 <.0001

DRUG 1 -0.53427757 B 5.07762456 -0.11 0.9167

DRUG 2 3.81185569 B 4.74671300 0.80 0.4262

DRUG 3 -11.27319523 B 5.33623888 -2.11 0.0402

DRUG 4 0.00000000 B . . .

DISEASE 1 -3.38659762 B 4.97844733 -0.68 0.4998

DISEASE 2 -1.52147765 B 4.74671300 -0.32 0.7500

DISEASE 3 0.00000000 B . . .

DRUG*DISEASE 1 1 6.41776239 B 6.88237665 0.93 0.3561

DRUG*DISEASE 1 2 3.71120124 B 7.14046097 0.52 0.6058

DRUG*DISEASE 1 3 0.00000000 B . . .

DRUG*DISEASE 2 1 1.76391853 B 7.00741651 0.25 0.8024

DRUG*DISEASE 2 2 3.30885035 B 7.27268983 0.45 0.6513

DRUG*DISEASE 2 3 0.00000000 B . . .

DRUG*DISEASE 3 1 14.89669169 B 7.84420858 1.90 0.0640

DRUG*DISEASE 3 2 -2.11408942 B 7.08463646 -0.30 0.7668

DRUG*DISEASE 3 3 0.00000000 B . . .



08:01 Monday, April 19, 2004




DRUG*DISEASE 4 1 0.00000000 B . . .

DRUG*DISEASE 4 2 0.00000000 B . . .

DRUG*DISEASE 4 3 0.00000000 B . . .

BSBP 1.58054117 0.09456791 16.71 <.0001




08:01 Monday, April 19, 2004




Number

1 131.823986 2.190358 <.0001 1

2 134.484721 2.095324 <.0001 2

3 121.969614 2.328955 <.0001 3

4 128.981942 2.122921 <.0001 4



i/j 1 2 3 4

1 0.3673 0.0042 0.3857

2 0.3673 0.0003 0.0821

3 0.0042 0.0003 0.0276

4 0.3857 0.0821 0.0276




Number

1 131.002058 1.872085 <.0001 1

2 128.324076 1.852009 <.0001 2

3 128.619063 1.827475 <.0001 3



i/j 1 2 3

1 0.3097 0.3740

2 0.3097 0.9121

3 0.3740 0.9121




08:01 Monday, April 19, 2004


DRUG DISEASE FSBP LSMEANStandard


Number

1 1 133.114854 3.383973 <.0001 1

1 2 132.273413 4.060386 <.0001 2

1 3 130.083690 3.508369 <.0001 3

2 1 132.807144 3.627652 <.0001 4

2 2 136.217196 4.121088 <.0001 5

2 3 134.429823 3.333471 <.0001 6

3 1 130.854866 4.572114 <.0001 7

3 2 115.709205 3.507901 <.0001 8

3 3 119.344772 3.919740 <.0001 9

4 1 127.231370 3.541742 <.0001 10

4 2 129.096490 3.333471 <.0001 11

4 3 130.617967 3.634277 <.0001 12



i/j 1 2 3 4 5 6 7 8 9 10 11 12

1 0.8687 0.5346 0.9486 0.5431 0.7922 0.6992 0.0009 0.0110 0.2465 0.4223 0.6317

2 0.8687 0.6836 0.9196 0.4808 0.6936 0.8208 0.0036 0.0270 0.3630 0.5620 0.7702

3 0.5346 0.6836 0.5902 0.2603 0.3765 0.8944 0.0058 0.0472 0.5711 0.8402 0.9167

4 0.9486 0.9196 0.5902 0.5208 0.7518 0.7439 0.0015 0.0155 0.2858 0.4707 0.6819

5 0.5431 0.4808 0.2603 0.5208 0.7476 0.3983 0.0005 0.0049 0.1125 0.2037 0.3322

6 0.7922 0.6936 0.3765 0.7518 0.7476 0.5228 0.0003 0.0052 0.1379 0.2448 0.4262

7 0.6992 0.8208 0.8944 0.7439 0.3983 0.5228 0.0115 0.0621 0.5301 0.7528 0.9672

8 0.0009 0.0036 0.0058 0.0015 0.0005 0.0003 0.0115 0.4929 0.0251 0.0079 0.0048

9 0.0110 0.0270 0.0472 0.0155 0.0049 0.0052 0.0621 0.4929 0.1421 0.0640 0.0402

10 0.2465 0.3630 0.5711 0.2858 0.1125 0.1379 0.5301 0.0251 0.1421 0.6974 0.4998

11 0.4223 0.5620 0.8402 0.4707 0.2037 0.2448 0.7528 0.0079 0.0640 0.6974 0.7500

12 0.6317 0.7702 0.9167 0.6819 0.3322 0.4262 0.9672 0.0048 0.0402 0.4998 0.7500



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEREGRESSION OF CHANGE ON BASELINE 08:01 Monday, April 19, 2004

The GLM Procedure



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEREGRESSION OF CHANGE ON BASELINE 08:01 Monday, April 19, 2004

The GLM Procedure

Dependent Variable: ISBP

Source DFSum of


Model 1 4728.191853 4728.191853 57.41 <.0001

Error 56 4611.963320 82.356488


R-Square Coeff Var Root MSE ISBP Mean

0.506222 48.06874 9.075048 18.87931

Source DF Type I SS Mean Square F Value Pr > F

BSBP 1 4728.191853 4728.191853 57.41 <.0001


BSBP 1 4728.191853 4728.191853 57.41 <.0001



Intercept -52.35507204 9.47658426 -5.52 <.0001

BSBP 0.64445394 0.08505371 7.58 <.0001


BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEDRUG BY DISEASE EFFECTS ON CHANGE IN B.P., UNADJUSTED

08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4

DISEASE 3 1 2 3




08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 11 4259.338506 387.212591 3.51 0.0013

Error 46 5080.816667 110.452536



0.456024 55.66750 10.50964 18.87931


DRUG 3 2997.471860 999.157287 9.05 <.0001

DISEASE 2 415.873046 207.936523 1.88 0.1637

DRUG*DISEASE 6 707.266259 117.877710 1.07 0.3958



08:01 Monday, April 19, 2004


DRUG ISBP LSMEANStandard


Number

1 25.9944444 2.7510078 <.0001 1

2 26.5555556 2.7510078 <.0001 2

3 9.7444444 3.1005583 0.0029 3

4 13.5444444 2.6371232 <.0001 4



i/j 1 2 3 4

1 0.8860 0.0003 0.0021

2 0.8860 0.0002 0.0013

3 0.0003 0.0002 0.3554

4 0.0021 0.0013 0.3554


DISEASE ISBP LSMEANStandard


Number

1 21.8166667 2.4925800 <.0001 1

2 19.7458333 2.4459856 <.0001 2

3 15.3166667 2.3743802 <.0001 3



i/j 1 2 3

1 0.5561 0.0653

2 0.5561 0.2003

3 0.0653 0.2003




08:01 Monday, April 19, 2004


DRUG DISEASE ISBP LSMEANStandard


Number

1 1 29.3333333 4.2905426 <.0001 1

1 2 28.2500000 5.2548201 <.0001 2

1 3 20.4000000 4.7000540 <.0001 3

2 1 28.0000000 4.7000540 <.0001 4

2 2 33.5000000 5.2548201 <.0001 5

2 3 18.1666667 4.2905426 0.0001 6

3 1 16.3333333 6.0677436 0.0099 7

3 2 4.4000000 4.7000540 0.3541 8

3 3 8.5000000 5.2548201 0.1126 9

4 1 13.6000000 4.7000540 0.0058 10

4 2 12.8333333 4.2905426 0.0045 11

4 3 14.2000000 4.7000540 0.0041 12



i/j 1 2 3 4 5 6 7 8 9 10 11 12

1 0.8738 0.1671 0.8350 0.5421 0.0722 0.0869 0.0003 0.0036 0.0172 0.0092 0.0216

2 0.8738 0.2713 0.9719 0.4835 0.1440 0.1445 0.0015 0.0108 0.0433 0.0278 0.0522

3 0.1671 0.2713 0.2588 0.0696 0.7272 0.5988 0.0201 0.0982 0.3116 0.2405 0.3558

4 0.8350 0.9719 0.2588 0.4393 0.1292 0.1353 0.0009 0.0081 0.0355 0.0213 0.0435

5 0.5421 0.4835 0.0696 0.4393 0.0286 0.0378 0.0002 0.0016 0.0070 0.0038 0.0088

6 0.0722 0.1440 0.7272 0.1292 0.0286 0.8062 0.0358 0.1609 0.4766 0.3840 0.5362

7 0.0869 0.1445 0.5988 0.1353 0.0378 0.8062 0.1268 0.3342 0.7234 0.6399 0.7823

8 0.0003 0.0015 0.0201 0.0009 0.0002 0.0358 0.1268 0.5637 0.1730 0.1917 0.1472

9 0.0036 0.0108 0.0982 0.0081 0.0016 0.1609 0.3342 0.5637 0.4731 0.5261 0.4230

10 0.0172 0.0433 0.3116 0.0355 0.0070 0.4766 0.7234 0.1730 0.4731 0.9046 0.9285

11 0.0092 0.0278 0.2405 0.0213 0.0038 0.3840 0.6399 0.1917 0.5261 0.9046 0.8309

12 0.0216 0.0522 0.3558 0.0435 0.0088 0.5362 0.7823 0.1472 0.4230 0.9285 0.8309



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEDRUG BY DISEASE EFFECTS ON CHANGE IN B.P., ADJUSTED FOR BSBP

08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4

DISEASE 3 1 2 3




08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 12 6575.030151 547.919179 8.92 <.0001

Error 45 2765.125021 61.447223



0.703953 41.52073 7.838828 18.87931


DRUG 3 1004.319714 334.773238 5.45 0.0028

DISEASE 2 77.440949 38.720474 0.63 0.5371

DRUG*DISEASE 6 480.017598 80.002933 1.30 0.2759

BSBP 1 2315.691646 2315.691646 37.69 <.0001



Intercept -44.08633346 B 10.12112729 -4.36 <.0001

DRUG 1 -0.53427757 B 5.07762456 -0.11 0.9167

DRUG 2 3.81185569 B 4.74671300 0.80 0.4262

DRUG 3 -11.27319523 B 5.33623888 -2.11 0.0402

DRUG 4 0.00000000 B . . .

DISEASE 1 -3.38659762 B 4.97844733 -0.68 0.4998

DISEASE 2 -1.52147765 B 4.74671300 -0.32 0.7500

DISEASE 3 0.00000000 B . . .

DRUG*DISEASE 1 1 6.41776239 B 6.88237665 0.93 0.3561

DRUG*DISEASE 1 2 3.71120124 B 7.14046097 0.52 0.6058

DRUG*DISEASE 1 3 0.00000000 B . . .

DRUG*DISEASE 2 1 1.76391853 B 7.00741651 0.25 0.8024

DRUG*DISEASE 2 2 3.30885035 B 7.27268983 0.45 0.6513

DRUG*DISEASE 2 3 0.00000000 B . . .

DRUG*DISEASE 3 1 14.89669169 B 7.84420858 1.90 0.0640

DRUG*DISEASE 3 2 -2.11408942 B 7.08463646 -0.30 0.7668

DRUG*DISEASE 3 3 0.00000000 B . . .



08:01 Monday, April 19, 2004

The GLM ProcedureDependent Variable: ISBP



DRUG*DISEASE 4 1 0.00000000 B . . .

DRUG*DISEASE 4 2 0.00000000 B . . .

DRUG*DISEASE 4 3 0.00000000 B . . .

BSBP 0.58054117 0.09456791 6.14 <.0001




08:01 Monday, April 19, 2004


DRUG ISBP LSMEANStandard


Number

1 21.2895030 2.1903578 <.0001 1

2 23.9502380 2.0953245 <.0001 2

3 11.4351316 2.3289553 <.0001 3

4 18.4474594 2.1229207 <.0001 4



i/j 1 2 3 4

1 0.3673 0.0042 0.3857

2 0.3673 0.0003 0.0821

3 0.0042 0.0003 0.0276

4 0.3857 0.0821 0.0276


DISEASE ISBP LSMEANStandard


Number

1 20.4675757 1.8720848 <.0001 1

2 17.7895931 1.8520092 <.0001 2

3 18.0845802 1.8274747 <.0001 3



i/j 1 2 3

1 0.3097 0.3740

2 0.3097 0.9121

3 0.3740 0.9121




08:01 Monday, April 19, 2004


DRUG DISEASE ISBP LSMEANStandard


Number

1 1 22.5803717 3.3839729 <.0001 1

1 2 21.7389305 4.0603864 <.0001 2

1 3 19.5492069 3.5083688 <.0001 3

2 1 22.2726611 3.6276523 <.0001 4

2 2 25.6827129 4.1210882 <.0001 5

2 3 23.8953402 3.3334706 <.0001 6

3 1 20.3203833 4.5721139 <.0001 7

3 2 5.1747222 3.5079012 0.1471 8

3 3 8.8102892 3.9197398 0.0295 9

4 1 16.6968869 3.5417419 <.0001 10

4 2 18.5620068 3.3334706 <.0001 11

4 3 20.0834845 3.6342770 <.0001 12



i/j 1 2 3 4 5 6 7 8 9 10 11 12

1 0.8687 0.5346 0.9486 0.5431 0.7922 0.6992 0.0009 0.0110 0.2465 0.4223 0.6317

2 0.8687 0.6836 0.9196 0.4808 0.6936 0.8208 0.0036 0.0270 0.3630 0.5620 0.7702

3 0.5346 0.6836 0.5902 0.2603 0.3765 0.8944 0.0058 0.0472 0.5711 0.8402 0.9167

4 0.9486 0.9196 0.5902 0.5208 0.7518 0.7439 0.0015 0.0155 0.2858 0.4707 0.6819

5 0.5431 0.4808 0.2603 0.5208 0.7476 0.3983 0.0005 0.0049 0.1125 0.2037 0.3322

6 0.7922 0.6936 0.3765 0.7518 0.7476 0.5228 0.0003 0.0052 0.1379 0.2448 0.4262

7 0.6992 0.8208 0.8944 0.7439 0.3983 0.5228 0.0115 0.0621 0.5301 0.7528 0.9672

8 0.0009 0.0036 0.0058 0.0015 0.0005 0.0003 0.0115 0.4929 0.0251 0.0079 0.0048

9 0.0110 0.0270 0.0472 0.0155 0.0049 0.0052 0.0621 0.4929 0.1421 0.0640 0.0402

10 0.2465 0.3630 0.5711 0.2858 0.1125 0.1379 0.5301 0.0251 0.1421 0.6974 0.4998

11 0.4223 0.5620 0.8402 0.4707 0.2037 0.2448 0.7528 0.0079 0.0640 0.6974 0.7500

12 0.6317 0.7702 0.9167 0.6819 0.3322 0.4262 0.9672 0.0048 0.0402 0.4998 0.7500



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEASSESSMENT OF DRUG BY BSBP INTERACTION -- TEST OF HOMOGENEITY OF SLOPES

08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEASSESSMENT OF DRUG BY BSBP INTERACTION -- TEST OF HOMOGENEITY OF SLOPES

08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 7 32453.95927 4636.27990 78.74 <.0001

Error 50 2944.10969 58.88219



0.916829 5.929409 7.673473 129.4138


DRUG 3 271.33816 90.44605 1.54 0.2167

BSBP 1 18288.60540 18288.60540 310.60 <.0001

BSBP*DRUG 3 341.60897 113.86966 1.93 0.1361



Intercept -23.34840426 B 16.58997516 -1.41 0.1655

DRUG 1 -54.31126788 B 26.20952684 -2.07 0.0434

DRUG 2 -18.58725894 B 22.13291416 -0.84 0.4050

DRUG 3 -6.17007090 B 29.73375116 -0.21 0.8365

DRUG 4 0.00000000 B . . .

BSBP 1.36125887 B 0.16155576 8.43 <.0001

BSBP*DRUG 1 0.51283950 B 0.23464594 2.19 0.0336

BSBP*DRUG 2 0.23335626 B 0.20607458 1.13 0.2629

BSBP*DRUG 3 -0.00719433 B 0.27892730 -0.03 0.9795

BSBP*DRUG 4 0.00000000 B . . .



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEASSESSMENT OF DRUG EFFECT WITH NESTED SLOPE MODEL

08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEASSESSMENT OF DRUG EFFECT WITH NESTED SLOPE MODEL

08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 7 32453.95927 4636.27990 78.74 <.0001

Error 50 2944.10969 58.88219



0.916829 5.929409 7.673473 129.4138


DRUG 3 271.33816 90.44605 1.54 0.2167

BSBP(DRUG) 4 22558.49031 5639.62258 95.78 <.0001



Intercept -23.34840426 B 16.58997516 -1.41 0.1655

DRUG 1 -54.31126788 B 26.20952684 -2.07 0.0434

DRUG 2 -18.58725894 B 22.13291416 -0.84 0.4050

DRUG 3 -6.17007090 B 29.73375116 -0.21 0.8365

DRUG 4 0.00000000 B . . .

BSBP(DRUG) 1 1.87409836 0.17017184 11.01 <.0001

BSBP(DRUG) 2 1.59461513 0.12793150 12.46 <.0001

BSBP(DRUG) 3 1.35406454 0.22737673 5.96 <.0001

BSBP(DRUG) 4 1.36125887 0.16155576 8.43 <.0001



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEASSESEMENT OF HOMOGENEITY OF SLOPES IN THE COMPLETE DESIGN

08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4

DISEASE 3 1 2 3



BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEASSESEMENT OF HOMOGENEITY OF SLOPES IN THE COMPLETE DESIGN

08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 23 33106.78967 1439.42564 21.36 <.0001

Error 34 2291.27930 67.39057



0.935271 6.343355 8.209176 129.4138


DRUG 3 161.62330 53.87443 0.80 0.5028

DISEASE 2 162.03311 81.01655 1.20 0.3130

DRUG*DISEASE 6 93.94756 15.65793 0.23 0.9631

BSBP 1 11489.86351 11489.86351 170.50 <.0001

BSBP*DRUG*DISEASE 11 473.84572 43.07688 0.64 0.7827


BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGEMODEL WITH SEPARATE SLOPES WITHIN CELLS

08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4

DISEASE 3 1 2 3




08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 23 33106.78967 1439.42564 21.36 <.0001

Error 34 2291.27930 67.39057



0.935271 6.343355 8.209176 129.4138


DRUG 3 161.62330 53.87443 0.80 0.5028

DISEASE 2 162.03311 81.01655 1.20 0.3130

DRUG*DISEASE 6 93.94756 15.65793 0.23 0.9631

BSBP(DRUG*DISEASE) 12 17638.15403 1469.84617 21.81 <.0001



Intercept -34.40673828 B 29.02948761 -1.19 0.2441

DRUG 1 -66.66088762 B 48.75036454 -1.37 0.1805

DRUG 2 -12.98110670 B 38.15047574 -0.34 0.7358

DRUG 3 -21.98090217 B 56.12558147 -0.39 0.6978

DRUG 4 0.00000000 B . . .

DISEASE 1 0.17891570 B 52.30450371 0.00 0.9973

DISEASE 2 22.56005320 B 39.51441177 0.57 0.5718

DISEASE 3 0.00000000 B . . .

DRUG*DISEASE 1 1 30.89778332 B 73.17430616 0.42 0.6755

DRUG*DISEASE 1 2 31.23429580 B 89.12760257 0.35 0.7282

DRUG*DISEASE 1 3 0.00000000 B . . .

DRUG*DISEASE 2 1 -13.90158646 B 70.69508275 -0.20 0.8453

DRUG*DISEASE 2 2 76.48940794 B 86.16440140 0.89 0.3809

DRUG*DISEASE 2 3 0.00000000 B . . .

DRUG*DISEASE 3 1 -5.67575179 B 94.80203246 -0.06 0.9526

DRUG*DISEASE 3 2 0.21386327 B 73.69675468 0.00 0.9977

DRUG*DISEASE 3 3 0.00000000 B . . .



08:01 Monday, April 19, 2004




DRUG*DISEASE 4 1 0.00000000 B . . .

DRUG*DISEASE 4 2 0.00000000 B . . .

DRUG*DISEASE 4 3 0.00000000 B . . .

BSBP(DRUG*DISEASE) 1 1 1.81302259 0.26820594 6.76 <.0001

BSBP(DRUG*DISEASE) 1 2 1.62031439 0.57092203 2.84 0.0076













BSBP = BASELINE, FSBP = FOLLOWUP, ISBP = F - B CHANGENO INTERACTION MODEL WITH COMMON SLOPE FOR BSBP

08:01 Monday, April 19, 2004

The GLM Procedure


Class Levels Values

DRUG 4 1 2 3 4

DISEASE 3 1 2 3




08:01 Monday, April 19, 2004

The GLM Procedure


Source DFSum of


Model 6 32152.92635 5358.82106 84.22 <.0001

Error 51 3245.14262 63.63025



0.908324 6.163838 7.976857 129.4138


DRUG 3 1263.43283 421.14428 6.62 0.0007

DISEASE 2 40.57604 20.28802 0.32 0.7284

BSBP 1 19702.97372 19702.97372 309.65 <.0001



08:01 Monday, April 19, 2004




Number

1 131.910254 2.188607 <.0001 1

2 134.399091 2.089746 <.0001 2

3 120.822956 2.322981 <.0001 3

4 128.868373 2.140399 <.0001 4



i/j 1 2 3 4

1 0.4022 0.0013 0.3525

2 0.4022 <.0001 0.0780

3 0.0013 <.0001 0.0123

4 0.3525 0.0780 0.0123




Number

1 130.189924 1.868146 <.0001 1

2 128.220025 1.855264 <.0001 2

3 128.590556 1.856401 <.0001 3



i/j 1 2 3

1 0.4545 0.5524

2 0.4545 0.8904

3 0.5524 0.8904


KUTNER BLOOD PRESSURE DATA -- UNBALANCED DESIGN … · kutner blood pressure data -- unbalanced...

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Transcript of KUTNER BLOOD PRESSURE DATA -- UNBALANCED DESIGN … · kutner blood pressure data -- unbalanced...