Defining American Psychology. The Correspon-dence Between Adolf Meyer and Edward BradfordTichener. Ruth Leys and Rand B. Evans, Eds. JohnsHopkins University Press, Baltimore, 1990. xvi, 292 pp.,illus. $42.50.Demographic and Programmatic Consequences

of Contraceptive Innovations. Sheldon J. Segal, Amy0. Tsui, and Susan M. Rogers, Eds. Plenum, New York,1989. xx, 318 pp., illus. $69.50. Reproductive Biology.From a conference, Washington, DC, Oct. 1988.

Dictionary of Scientific Biography. Supplement II(vols. 17 and 18). Frederic L. Holmes, Ed. Scribner,New York, 1990. xii, 1076 pp., illus. $160.

Dietary Fiber. Chemistry, Physiology, and HealthEffects. David Kritchevsky, Charles Bonfield, and JamesW. Anderson, Eds. Plenum, New York, 1990. xx, 499pp., illus. $95. From a conference, Washington, DC,April 1988.

Differentiation and Functions of Glial Cells.Giulio Levi, Ed. Wiley-Liss, New York, 1990. xxviii, 429pp., illus. $102. Neurology and Neurobiology, voL 55.From a meeting, Rome, April 1989.Digging Dinosaurs. John R. Homer and James

Gorman. Illustrated by Donna Braginetz and Kris Ell-ingsen. Harper and Row, New York, 1990. 210 pp.Paper, $8.95. Reprint, 1988 ed.Dlscordant ifarmonles. A New Ecology for the

Twenty-first Century. Daniel B. Botkin. Oxford Univer-sity Press, New York, 1990. xii, 241 pp., illus. $19.95.

Disorders of Upid Metabolism. Guido V. Mari-netti. Plenum, New York, 1990. xiv, 226 pp., illus. $50.

Drifting Continents and Colliding Paradigms.Perspectives on the Geoscience Revolution. John A.Stewart. Indiana University Press, Bloomington, 1990.xvi, 285 pp., illus. $35. Science, Technology, and Soci-ety.The Early Universe. Edward W. Kolb and Michael

S. Turner. Addison-Wesley, Redwood City, CA, 1990.xxii, 547 pp., illus. $48.50. Frontiers in Physics: LectureNote Senes, 69.Ecology and Field Biology. Robert Leo Smith. 4th

ed. Harper and Row, New York, 1990. xx, 922 pp.,illus., + glossary, bibliography, and index. With studentresource manual. $47.25.Essence of Creativity. A Guide to Tackling Difficult

Problems. Steven H. Kim. Oxford University Press, NewYork, 1990. x, 134 pp., illus. $29.95.

Evolution Biologique. Quelques Donnees Actuelles.Jacques Bons and Michel Delsol, Eds. Editions Boubee,Paris, and Association A.A.A., Lyon, 1989. 314 pp.,illus. Paper, FF220. Ecole Pratique des Hautes Etudes.Originaly published with the support of Naturalia etBiorogia. From a colloquium, Lyon, July 1987.Exact Solutions of Relativistic Wave Equations.

V. G. Bagrov and D. M. Gitman. Kluwer, Boston, 1990.x, 323 pp., illus. $113. Mathematics and Its Applications(Soviet Series), vol. 39.Facets of Modern Blogeochemistry. Festschrift for

E. T. Degens. V. Ittekkot et al., Eds. Springer-Verlag,New York, 1990. xiv, 433 pp., illus. $75.The Facts on File Dictionary of Biology. Elizabeth

Tootill, Ed. Facts on File, New York, 1990. viii, 326 pp.,illus. Paper, $12.95. Reprint, 1988 ed.The Facts on Flie Dictionary of Chemistry. John

Daintith, Ed. Facts on File, New York, 1990. vi, 249pp., illus. Paper, $12.95. Reprint, 1988 ed.The Facts on Flie Dictionary of Marine Science.

Barbara Charton. Facts on File, New York, 1990. vi, 326pp., illus. Paper, $12.95. Reprint, 1988 ed.Financing a College Education. The Essential

Guide to the 90s. Judith B. Margolin. Plenum, NewYork, 1989. xii, 307 pp., illus. $14.95.

Fire and Ice. The Greenhouse Effect, Ozone Deple-tion, and Nudear Winter. David E. Fisher. Harper andRow, New York, 1990. vi, 232 pp., illus. $19.95.The Fishes of New Mexico. James E. Sublette,

Michael D. Hatch, and Mary Sublette. University ofNew Mexico Press, Albuquerque, 1990. xvi, 393 pp.,illus., + plates. $50.Formal Methods In Human-Computer Inter-

action. Michael Harrison and Harold Thimbleby. Cam-bridge University Press, New York, 1990. xviii, 323 pp.,illus. $39.50. Cambridge Series on Human-ComputerInteraction, 2.Formation and Control of Optical Wavefronts. P.

P. Pashinin, Ed. Nova, New York, 1989. viii, 209 pp.,illus. $62. Proceedings ofthe Institute ofGcneral PhysicsAcademy of Sciences of the USSR, vol. 7. Translatedfrom the Russian edition (1987) by Kevin S. Hendzel.

Free-Electron Lasers. Charles A. Brau. AcademicPress, San Diego, CA, 1990. xii, 420 pp., illus. Paper,$79.95. Advances in Electronics and Electron Physics,22.

Freud at the Crossroads. Alexander Grinstein. In-ternational Universities Press, Madison, CT, 1990. xviii,612 pp., illus. $65.Human Resource Strategies for Organization in

Transition. Richard J. Niehaus and Karl F. Price, Eds.Plenum, New York, 1990. viii, 335 pp., illus. $69.50.From a symposium, Newport, RI, June 1989.

Hypertext and Hypermedia. Jakob Nielsen. Aca-demic Press, San Diego, CA, 1990. xii, 263 pp., illus.$29.95.

Identity and Reality. Emile Meyerson. Gordon andBreach, New York, 1989. ii, 495 pp. Paper, $39. Classicsin the History and Philosophy of Science, vol. 4. Trans-lated from the French edition (1908) by Kate Loewen-berg. Reprint, 1929 ed.

Imagery. Current Perspectives. Joseph E. Shorr et al.,Eds. Plenum, New York, 1989. viii, 200 pp., illus. $55.From conferences, Toronto, Canada, June 1987, andNew Haven, CT, June 1988.

Information and the Origin of Ufe. Bemd-OlafKuppers. MIT Press, Cambridge, MA, 1990. xxiv, 215pp., illus. $22.50. Translated from the German edition(Munich, 1986).

inswcticide Action. From Molecule to Organism.Toshio Narahashi and Janice E. Chambers, Eds. Plenum,New York, 1989. viii, 275 pp., illus. $69.50. From asymposium, Los Angeles, Sept. 1988.

Introduction to Functional Histology. Ira R. Tel-ford and Charles F. Bridgman. Harper and Row, NewYork, 1990. xxii, 598 pp., illus., + plates. $47.50.Uthium and Cell Physlology. Ricardo 0. Bach and

Vincent S. Gallicchio, Eds. Springer-Verlag, New York,1990. x, 174 pp., illus. $69.Uves at Risk. Public Health in Nineteenth-Century

Egypt. LaVeme Kuhnke. University of Califomia Press,Berkeley, 1990. x, 233 pp. $40. Comparative Studies ofHealth Systems and Medical Care, vol. 24.Managing Coastal Erosion. Committee on Coastal

Erosion Zone Management, National Research Council.National Academy Press, Washington, DC, 1990. xvi,182 pp., illus. $24.50.Managing Troubled Waters. The Role of Marine

Environmental Monitoring. Committee on a SystemsAssessment of Marine Environmental Monitoring, Na-tional Research Council, Washington, DC, 1990. x, 125pp., illus. $24.50.Marsh Management in Coastal Louisiana. Effects

and Issues-Proceedings of a Symposium (Baton Rouge,LA, June 1988). Walter G. Duffy and Darryl Clark, Eds.U.S. Fish and Wildlife Service, Washington, DC, andLouisiana Department of Natural Resources, BatonRoute, 1989. viii, 378 pp., illus. Paper. U.S. Fish andWildlife Services Biological Report 89 (22).Measurement of Nigh-Spoed Signal In Solid

State Devices. Robert B. Marcus, Ed. Academic Press,San Diego, CA, 1990. xvi, 438 pp., illus. $85. Semicon-ductors and Semimetals, vol. 28.Membrane Technology. Roberto Vema, Ed. Raven,

New York, 1989. xii, 155 pp., illus. $66. Serono Sym-posia Publications, vol. 64. From a course and sympo-sium, Rome, June 1989.Membrane Transport and Information Storage.

Roland C. Aloia, Cyril C. Curtain, and Larry M. Gor-don, Eds. Wiley-Liss, New York, 1990. x, 260 pp., illus.$137. Advances in Membrane Fluidity, vol. 4.The Merger of Knowledge with Power. Essays in

Critical Science. J. R. Ravetz. Mansell, New York, 1990.x, 326 pp., illus. $49.50.

MetaAiNzed Plastics 1. Fundamental and AppliedAspects. K. L. Mittal and J. R. Susko, Eds. Plenum, NewYork, 1990. x, 284 pp., illus. $65. From a symposium,Chicago, Oct. 1988.Methods In Neurotransmitter Receptor Analysls.

Henry I. Yamamura, S. J. Enna, and Michael J. Kuhar,Eds. Raven, New York, 1990. xii, 267pp., illus. $55.Moiecular Electronics. Biosensors and Biocomput-

ers. Felix T. Hong, Ed. Plenum, New York, 1989. xii,454 pp., illus. $95. From a symposium, Santa Clara, CA,July 1988.

lolecular Evolution. Michael T. Clegg2 and StephenJ. O'Brien, Eds. Wiley-Liss, New York, 1990. xviii, 322pp., illus. $86. UCLA Symposia on Molecular andCellular Biology, vol. 122. From a colloquium, LakeTahoe, CA, March 1989.

Molecular Machinery. The Principles and Powers ofChemistry. Andrew Scott. Basil Blackwell, Cambridge,MA, 1989. viii, 192 pp., illus. $19.95.

Molecular Mechanisms in DNA Repiication andRecombination. Charles C. Richardson and I. RobertLehman, Eds. Wiley-Liss, New York, 1990. xxii, 415pp., illus. $110. UCLA Symposia on Molecular andCellular Biology, New Series, vol. 127. From a sympo-sium, Keystone, CO, April 1989.

Newton's Madness. Further Tales of Clinical Neu-rology. Harold L. Klawans. Harper and Row, NewYork, 1990. xiv, 218 pp. $17.95.1939-1989: Fifty Years Progress in Allergy. A

Tribute to Paul Kall6s. Byron H. Waksman, Ed. Karger,New York, 1990. xii, 284 pp., illus. $168. ChemicalInmmunology, vol. 49.Novel Approaches to the Treatment of Alzhe-

lmer's Disease. Edwin M. Meyer, James W. Simpkins,and Jyunji Yamamoto, Eds. Plenum, New York, 1989.xiv, 386 pp., illus. $85. Advances in Behavioral Biology,vol. 36. From a workshop, St. Petersburg, FL, Mar.1989.Nuclear Matter and Heavy Ion Coliisions.

Madeleine Soyeur et al., Eds. Plenum, New York, 1989.xii, 500 pp., illus. $125. NATO Advanced ScienceInstitutes Series B, vol. 206. From a workshop, LesHouches, France, 1989.Nucleic Acid Methylation. Gary A. Clawson et al.,

Eds. Wiley-Liss, New York, 1990. xx, 425 pp., illus.$120. UCLA Symposia on Molecular and Celular Biol-ogy, vol. 128. From a colloquium, Frisco, CO, April1989.Number Theory and Physics. J.-M. Luck, P.

Moussa, and M. Waldschmidt, Eds. Springer-Verlag,New York, 1990. xiv, 311pp., illus. $58.30. SpringerProceedings in Physics, vol. 47. From a winter school,Les Houches, France, March 1989.Oncogenes and the Molecular Origins of Cancer.

Robert A. Weinberg, Ed. Cold Spring Harbor Labora-tory, Cold Spring Harbor, NY, 1989. xii, 367 pp., illus.Paper, $55. Monograph Series 18.

Politics and Public Health In Revolutionary Rus-sia, 1890-1918. John F. Hutchinson. Johns HopkinsUniversity Press, Baltimore, 1990. xxii, 253 pp., illus.$42. Henry E. Sigerist Series in the History ofMedicine.Power In the Hlghest Degree. Professionals and the

Rise of a New Mandarin Order. Charles Derber, WilliamA. Schwartz, and Yale Magrass. Oxford University Press,New York, 1990. x, 275 pp. $24.95.

Principles of Anatomy and Physiology. Gerard J.Tortora and Nicholas P. Anagnostakos. 6th ed. Harperand Row, New York, 1990. xxvi, 956 pp., illus., +appendix, bibliography, and index. $53.35.Proceedings of the Xlth Congress of the Interna-

tional Society of Blometeorology. (West Lafayette,IN, Sept. 1987.) D. Driscoll, E. 0. Box, and H. Lieth,Eds. SPB, The Hague, 1989. xviii, 407 pp., illus. Paper,$95.Proceedings of the Fourth European Symposium

on Thermal Analysis and Calorimetry. (Jena,G.D.R., Aug. 1987.) D. Schultze, Ed. Wiley, Chichester,U.K., and Akademiai Kiado, Budapest, 1989. 2 vols.1297 pp., illus. $60. Journal of Thermal Analysis, vol.33.Race to Save the Tropics. Ecology and Economics

for a Sustainable Future. Robert Goodiand, Ed. IslandPress, Washington, DC, 1990. xvi, 219 pp. $45; paper,$24.95.

Radiation Exchange. An Introduction. Jack H. Tay-lor. Academic Press, San Diego, CA, 1990. xii, 127 pp.,illus. $24.95.Spinors and Calibrations. F. Reese Harvey. Aca-

demic Press, San Diego, CA, 1990. xiv, 323 pp., illus.$39.95. Perspectives in Mathematics, vol. 9.

Spotiight on the Cities. Improving Urban Health inDeveloping Countries. I. Tabibzadeh, A. Rossi-Espag-net, and R. Maxwell. World Health Organization,Geneva, 1989 (U.S. distributor, WHO PublicationsCenter, Albany, NY). vi, 174 pp., illus. Paper, $24.Squid as Experimental Animals. Daniel L. Gilbert,

William J. Adelman, Jr., and John M. Arnold, Eds.Plenum, New York, 1990. xxxii, 516 pp., illus. $75.

Straight and Devious Pathways from Childhoodto Adulthood. Lee N. Robbins and Michael Rutter,Eds. Cambridge University Press, New York, 1990. xxii,389 pp., illus. $59.50. Based on a meeting, Oct. 1987.Stress Proteins In Biology and Medicine. Richard

I. Morimoto, Alfred Tissieres, and Costa Georgopoulos,Eds. Cold Spring Harbor Laboratory, Cold Spring Har-bor, NY, 1990. x, 450 pp., illus. $97. Cold SpringHarbor Monograph Series.

Transition Metals in Total Synthesis. Peter J.Harrington. Wiley-Interscience, New York, 1990. xviii,484 pp., illus. $59.95.Unexplalned Infertility. Basic and Clinical Aspects.

Giovanni Spera and Lucio Gnessi, Eds. Raven, NewYork, 1990. xii, 303 pp., illus. $78. Serono SymposiaPublications from Raven Press, vol. 62. From a sympo-sium, Rome, March 1989.Western Apache Language and Culture. Essays in

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Rush Presbyterian-St. Luke's Medical Center seeksapplicants with Ph.D. in physics, biomedical engineer-ing, or a related field; experience and publications incardiovascular applications, image processing, and three-dimensional display; and interest in MRI pulse program-ming. Position includes appointment as ASSISTANTPROFESSOR in diagnostic radiology and nuclear med-icine and includes responsibility for teaching graduatestudents in medical physics, as well as participation in anMRI research program. Send curriculum vitae, reprintsof relevant publications, and cover letter to: David A.Turner, M.D., 1653 West Congress Parkway, Chi-cago, IL 60612, by 3 August 1990. Rush-Presbyterian-St.Luke's Medical Center is an Equal Opportunity/AfirmativeAction Employer.

PERMANENT TRACK (ASSISTANT/ASSOCI-ATE OR FULL PROFESSOR). Position in develop-mental immunology and/or immunological aspects ofhematopoiesis. Successful applicants will be expected todevelop outstanding independent research programswhich could involve, for example: B or T cell ontogeny,development of T cell repertoire, or cytokine regulationof lymphocyte development. Strong interest in graduateand postdoctoral education programs required. Highlyinteractive, academic immunology department of tenindependent laboratories located within Mayo Clinicmedical complex. Excellent laboratory facilities. Start-upfunds are available. Candidates with proven productivityand credentials please send curriculum vitae, statement ofresearch interests, and names of three references to:Larry R. Pease, Ph.D., Department of Immunology,Mayo Clinic, Rochester, MN 55905. An Equal Oppor-tunity/Afirmative Action Employer.

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PROTEIN BIOCHEMISTCangene Corporation, The Canadian Genetic Engineering Company, hasdeveloped a new and novel expression technology which the Company is

using to produce a range of biopharmaceuticals. The Company Is seekingan outstanding Indivdual to fill a challenging postion within itsBiochemistry Group.

The selected candidate will contribute to the direction of the research ofmicrobial proteases related to the Company's expression system and applyexisting techniques or develop new methodologies for their isolation,purification and characterization. This individual will also be responsible fordeveloping the knowledge required for the understanding of the proteases'mechanism of action and their activity Inhibition.The successful candidate will have:* A Ph.D In an area related to Chemistry/Biochemistry of proteins* Strong updated scientific background and at least three years of post-graduate experience in the area of protease activity and its inhibition

* Sound experience In Isolation, purification and characterization ofproteins, preferably proteases

* Ability to scientifically direct and manage small project team* Sound verbal and written communication skills* Ability to interact in an interdisciplinary manner.

Cangene Corporation Is located near Toronto, one of North America's mostlivable cities. The Company offers an attractive compensation package andthe opportunity to work In'a highly creative, goal-oriented atmosphere.Candidates are required to submit, In strictest confidence, quoting file#0529, their curriculum vitae and the names of three referees to: Manager,Human Resources, Cangene Corporation, 3403 American Drive,Mississauga, Ontario, Canada L4V 1T4.

The Canadian Genetic_E- _ engmeermge;~~~~ompany

RESEARCH SCIENTISTprotein chemistryOur client, a major Detroit manufacturing company with modernplant locations throughout the United States, has an exceptionalopportunity available for a Research Scientist in ProteinChemistry.You will be working with a specialized group of scientists in theareas of molecular biology and fermentation. This highlychallenging project involves the use of protein engineering in thedesign of proteins for therapeutic use in humans.This position requires that you have a Ph.D. or M.S. andexperience in state-of-the-art protein chemistry techniques. Astrong background in protein purification and characterizationalong with experience in a wide variety of protein chemistrytechniques and instrumentation is essential.Our client offers a competitive compensation and completebenefits package. Qualified candidates are invited to send theirresume to: Confidential Reply Service, Dept. AJK, ThompsonRecruitment Advertising, 3000 Town Center, Suite 1600,Southfield, Ml 48075. All replies will be forwarded to our clientunopened. No phone calls please. Our client is an equalopportunity employer M/F/H/V.

Confidential Reply Service

Thompson Recruitment Advcrtising *29 JUNE 1990

POSITIONS OPEN

PROFESSOR AND CHAIRPERSONDEPARTMENT OF PHARMACOLOGY

The College ofMedicine ofHoward University invitesapplications and nominations for the position of chair-person of the Department of Pharmacology. The candi-date should possess a Ph.D. degree in pharmacology orthe M.D. degree with significant research contributionsin pharmacology. Applicants should have a demonstratedrecord of accomplishment in research, teaching, andadministration. The Department of Pharmacology isresponsible for educational programs for medical, dental,pharmacy, and graduate students. The department hasstrong research programs in several specialty areas ofbasic and clinical pharmacology.Nominations and applications should be received be-

fore September 1990. pplcations, consisting of a letterof intent, curriculum vitae, and three references, shouldbe sent to: Allen R. Rhoads, Ph.D., Chairman of theSearch Committee, Department of Biochemistry,College of Medicine, Howard University, 520 WStreet, N.W., Washington, DC 20059. Howard Univer-sity is an Equal Opportunity/Afrmative Aaion Employer.

- ^ - Agricultural United StatesResearch Department ofService Agriculture

CENTER DIRECTORWESTERN REGIONAL

RESEARCH CENTER (WVRRC)ALBANY, CALIFORNIA

ARS is seeking applicants for the position of director,WRRC, the mission of which is to provide, throughchemical, biological, biotechnological, and other researchapproaches, solutions to problems affecting the qualityand quantity of the nation's food supply. In addition toproviding leadership and operational accountability forWRRC's multidisciplinary research programs, the direc-tor participates with agency management in planning,coordinating, and evaluating overall area research pro-grams. The center has a budget of over $13 milGion,employing 200+ scientific and support personnel. This isa senior executive service position with a current salaryrange of $71,200 to $83,600 (a significant increase isexpected in January 1991). Ph.D. is desirable. Candi-dates must address managerial and technical evaluationfactors listed in announcement. For copy of announce-ment, call Mr. Lee Triplett at 301-344-4622 by 20 July1990. Applications must be received by 30 July 1990.ARS is an Equal Opportunity Employer. Women and minori-ties are encouraged to apply.

CHIEF OPERATING OFFICER. For universityconsortium to work with major DOE contractor onsponsored research and educational activities. Shouldhave experience in research management at the highestlevels and the demonstrated ability to work effectively incomplex organizations. This position will report directlyto a board composed of the presidents of four publicinstitutions and will be charged with the development ofprocedures required to implement an existing coopera-tive agreement among the institutions and the DOEcontractor. Eamed doctorate in a technical field pre-ferred; salary commensurate with experience. By 23 July1990, send curriculum vitae and letters of reference to:Dr. Robert E. Alexander, Chair, SCUREF SearchCommittee, University of South Carolina-Aiken,171 University Parkway, Aiken, SC 29801. An Affir-mative Action/Equal Opportunity Employer.

LABORATORY CHIEF POSMIION. At the Ad-diction Research Center. A position is available to directa small laboratory, composed of staff fellows and supportstaff, within the neuroscience branch. The mission of thelaboratory is the utilization of molecular, neurochemical,neuroanatomical, and pharmacologic techniques to ex-plore the mechanism of action of drugs, drug abuse, anddependence. The role of the chief will be to recruit andsupervise staff, plan and conduct experimental studies,and to publish results. The position requires an investi-gator with a Ph.D. or M.D. degree and a substantialtrack record of achievement. Salary range is $59,216 to$76,982 depending on experience and qualifications.U.S. citizenship is required. Send curriculum vitae to: Dr.Michael J. Kuhar, NIDA Addiction Research Center,P.O. Box 5180, Baltimore, MD 21224. The Akohol,DTugAbuse, and Mental HealthAdministration (ADAMHA)is an Equal Opportunity Employer. ADAMHA is smokefreeand drugfree.

I674

DIRECTOR, Prince William Sound Science Center,Cordova, Alaska, a private, nonprofit institution support-ing basic and applied research in the Prince WilliamSound region. Requirements: earned doctorate in anenvironment-relevant discipline, or equivalent institu-tional leadership experience; administrative exprience;ability to generate financial support; and supenor inter-personal communication skills. To apply or obtain fur-ther details, call 907-424-5800 by 18 July 1990.

COMPUTER SIMULATION/TOXICOLOGY.Anticipated expansion of our Biosimulation ResearchProgram will make a position available for a Ph.D. (orequivalent) to develop biologically based computer sim-ulation models. Models currently under developmentinclude: physiologically based pharmacokinetics, bio-chemical mechanisms of toxicity, and chemical carcino-genesis. Solid background in biology/biochemistry/chemistry, with interest in applying these skills to com-puter simulation, desired. Simulation model developmentwill complement ongoing and proposed laboratory stud-ies. Publication of all results and presentation at nationalmeetings is encouraged. Title and salary will be commen-surate with background and experience. Interested individ-uals should send curriculum vitae, together with namesand addresses ofthree references, to: Ms. Lois Doncaster,Human Resources/05, NSI Technology Services Cor-poration, Environmental Sciences, A ManTech Inter-national Company, 101 Woodman Drive, Suite 12,Dayton, OH 45431.NSI Technology Servics Corporation is an Equal Opportu-

nity Employer.

ENVIRONMENTAL HEALTHThe Program in Social Ecology at the University of

California, Irvine, is recruiting for an ASSISTANTPROFESSOR, tenure-track position in the area ofEnvironmental Health Science and Policy. Applicantsshould have received a Ph.D. in environmental sciences,environmental chemistry, molecular and environmentalbiotechnology, or biochemistry. The successful candidateshould have demonstrated experience in laboratory orfield research related to environmental sciences or health.Ability to teach statistics and environmental testingmethodology is desirable.The Program in Social Ecology grants B.A., M.A., and

Ph.D. degrees. The 30 full-time faculty have multidis-ciplinary interests and expertise in environmental sci-ences, public health, demography, urban planning, envi-ronmental law, and environmental psychology. TheSocial Ecology Building houses four laboratories: ultra-clean monitoring, water quality, microbial ecology andbioremediation laboratory, radiocarbon dating and envi-ronmental chemistry laboratory, and a full-scale environ-mental simulation laboratory.

Candidates should submit a letter of application, cur-riculum vitae, and names of three references to:

Dr. Betty H. Olson, ChairEnvironmental Health Search Comnmittee

Program in Social EcologyUniversity of California

Irvine, CA 92717Closing date for applications is 30 November 1990.

The University of Cal:fiomia is an Equal Opportunity/Affir-mative Action Employer.

FACULTY POSMTIONSIN CELL BIOLOGY

Tenure-track ASSISTANT/ASSOCIATE PRO-FESSOR positions available in a Department of CellBiology. The department currently has strong researchprograms in cell biology, molecular biology, neurobiol-ogy, reproductive biology, and developmental biology;we are seeking candidates who can interact in any ofthese areas and have potential to develop independentresearch careers. Teaching responsibility is in the area ofcell biology/histology. Send curriculum vitae and threeletters of reference to: Reid L. Norman, Cell Biologyand Anatomy, Texas Tech University Health SciencesCenter, Lubbock, TX 79430. Texas Tech UniversityHealth Sciences Center is an Equal Opportunity/AffirmativeAction Employer.

SCIENCE welcomes placement of line classified adsby FAX. Please include name and telephone number forour confirmation call when transmitting ad to:

FAX NUMBER: 202-682-0816

ENVIRONMENTAL ENGINEER, AIR POL-LUTION. After consultation with clients, gather andanalyze data to determine environmental hazardous airpollution; data is gathered by on-site inspection, usingclient-provided engineering or architectural drawings,sometimes gather air material samples. Analyze data inthe office, sometimes using a personal computer utilizingFORTRAN or PASCAL computer language, sometimesusing air pollution dispersion modeling. Devise andpropose problem solution, such as: change client's man-ufacturing process or install or change pollution controldevices. Supervise other environmental engineers. Re-quires Ph.D. degree in environmental engineering. Alsorequires 1 year of experience in the job to be performed.Must have taken at least one college-level course inFORTRAN and PASCAL computer languages, air pol-lution dispersion modeling, and at least four graduate-level courses on air pollution. Will accept 1 year ofexperience as college research assistant, environmentalengineering, air pollution, in lieu of the job experience.Experience can be during academic career. May completePh.D. coursework in lieu of actual degree. Hours: 9:00a.m. to 5:00 p.m., 40 hours per wee at $40,000 peryear salary. Please send resume to: illnois Departmentof Employment Security, 401 South State Street-3South, Chicago, IL 60605, Attention: L. Donegan,Reference #1509-D. An employer-paid ad.

FACULTY POSMON, DEPARTMENT OFPATHOBIOLOGICAL SCIENCES

SCHOOL OF VETERINARY MEDICINEUNIVERSITY OF WISCONSIN-MADISONANATOMICAL PATHOLOGIST. Faculty posi-

tion at rank of ASSISTANT PROFESSOR OR AS-SOCIATE PROFESSOR. Responsibilities includenecropsy/surgical pathology service for the VeterinaryMedical Teaching Hospital, veterinary student teaching,and research. Excellent opportunities and resources avail-able in department for infectious disease research.D.V.M. or D.V.M./Ph.D. degrees or equivalents. ACVPcertification or an intention to achieve certification isdesired.Send curriculum vitae and names of at least three

references to: Dr. R D. Schultz, Professor and Chair-man, Department ofPathobiological Sciences, Schoolof Vetennary Medicine, University of Wisconsin-Madison, 2015 Linden Drive West, Madison, WI53706. Telephone: 608-263-9888. An Equal Opportu-nity/Affimative Action Employer.

OKLAHOMA CENTEROF MOLECULAR MEDICINE

ENDOWED CHAIRSPositions: Four full-time, tenure-track chair positions

are available in the Oklahoma Center of MolecularMedicine. These chairs are professional positions in theCollege of Medicine of the University of OklahomaHealth Sciences Center. The chair holders will havefull-time appointments in departments of the College ofMedicine of their choosing.

Salary: Salary will be commensurate with rank andexperience.

Responsibilities: The individuals who hold the en-dowed chairs in molecular medicine will be expected tohave active and productive research careers. These indi-viduals will play important roles in the research programof their departments, in the Oklahoma Center of Molec-ular Medicine and the Medical/Scientist Training Pro-gram. In addition to being active research scientists, thesechair holders will serve as model research professors andresources for students, junior faculty, and other researchscientists.

Requirements: Any postbaccalaureate degree such asPh.D., Sc.D., M.D., or other professional degree will beacceptable. No specific areas of endeavor are specified,but preference will be given to individuals whose re-search is in the neurosciences and in protein structure andfunction with NMR experience.

Deadline: The deadline for applications is 1 September1990 or until filled.Address application to:

John R. Sokatch, Ph.D., ChairmanDepartment of Biochemistry and Molecular BiologyUniversity of Oklahoma Health Sciences Center

P.O. Box 26901Oklahoma City, OK 73190

The University of Oklahoma is an Equal Opportunity!Affirmative Action Employer.

SCIENCE, VOL. 248

POSITIONS OPEN POSITIONS OPEN

Cargill, a world leader in industry and agribusiness, is seekingtwo talented chemists who have a demonstrated history ofindependent accomplishments. The successful candidates willbe working to develop new products or new processes basedon the separation, manipulation, or modification of agriculturalmaterials. To qualify, a Ph.D. in organic chemistry, biochemis-try or related field, or a M.S. plus a minimum of 5 years experience.Senior Research Chemist LipidsThis position focuses on lipids in agricultural materials such astriglycerides in fats and oils, and phospholipids in vegetable oils.The areas of research will include:* Enzymatic modification of lipids;* Determining the effect of processing conditions of fatty acid

distribution;* Chemical and physical characteristics of phospholipids in anon-aqueous environment.

Senior Research Chemist CarbohydratesThis position focuses on Carbohydrates in agricultural materials,particularly the production and utilization of new carbohydratesyrups.* Lead and conduct several technical projects simultaneously;* Convert the technologydeveloped into commercial processesand/or products;

* Increase knowledge in enzymology, food technology partic-ularly related to syrups.

Cargill offers a competitive salary, pleasant work environment,and a strong benefits package. If you wish to be a member ofa dedicated team of professionals, please send your resume toDonna Bloom.

CargillHRD #10, Box 9300Minneapolis, MN 55440

An Equal Opportunity Emplover

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Explore your future at the forefront of some oftoday's most significant advances in biotech-nology. Aggressive, goal-driven research givesSchering-Plough its competitive edge in thehealthcare industry. This is your opportunity toapply your innovative thinking in exciting areasof research that include the following:Molecular Biology-You will be part of aresearch project focused on cloning and ex-pression of the immunoglobulin repertoirederived from immunization of human lympho-cytes/b7 vltro. This will involve a multidisciplinaryapproach involving cell culture, cDNA cloningusing the polymerase chain reaction, construc-tion of antibody chimeras, and heterologousgene expression in E co//and/or mammaliancells. Requires a Ph.D. in Molecular/Cell Bio-logy, Immunology, Biochemistry or relatedfield. Familiaritywith recombinant DNA/geneticengineering technology preferred.

Biochemistry-To conduct research on thestructure of recombinant cytokines and relatedpolypeptides usingNMR spectroscopy. Requiresa Ph.D. in Biochemistry or related disipline,and a background in the physical biochemistryof proteins and polypeptides, including ex-perience in two-dimensional NMR techniquesand distance geometry measurements.At Schering-Plough, you'll receive all the sup-port and recognition to pursue your best ideas.In addition to outstanding resources and anexciting research environment, we offer an at-tractive salary and benefits package. For im-mediate, confidential consideration, forwardyourresumeandsalaryhistoryto: Mr. G. Czuba,Schering-Plough Research, 60 Orange Street,Bloomfield, NJ 07003. We are an equal oppor-tunity employer.

56~0 Schering-Plough

FACULTY OF MEDICINE

UNITED ARAB EMIRATES UNIVERSITY

Applications are invited for appointment at Assistant, Associate andfull Professorial rank in the Department of Biochemistry.Candidates must possess a medical degree and/or PhD degree or anequivalent higher professional degree from an accredited university orinstitution of higher learning, or any higher professional certificate suchas Membership or Fellowship in the Royal College of the UK, Ireland,Canada, Australia and New Zealand (MRCP, FRCS, MRC Path, MRCPsych., FFARCS, MRCOG, FRCR), or the certificate of the AmericanBoard or the Arab Board for Medical Specializations. The language ofinstruction is English.Candidates for these positions must be able to demonstrate leadershipexperience in the development of teaching, research and, whereappropriate, clinical service programmes.

Persons interested in additional information on applying should send acurriculum vitae including list of publications, copies of certificates andthe names of three current referees to:

Joel H. Lanphear, Ph.D.Associate Dean

Faculty of MedicineUAE UniversityPO Box 17666

Al AinUnited Arab EmiratesFax No: 971 3 638247

Applications will be closed six weeks after date of publication orSeptember 15, 1990 whichever occurs first.

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Southern California Location

Baxter Healthcare

Corporation, an inter-

national leader in the

pharmaceutical

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exceptional career

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for experienced

professionals in our

Hyland Division located

in Duarte, CA.

* PROCESS ANALYSIS SCIENTIST Responsibil-ities include planning and implementing thetesting of patient samples from cataloging andshipping through actual testing, developingnew assays, and conducting process and assayvalidation. The ability to develop chemical,biochemical and immunological assays is essen-tial. We also require either a BS degree in Bio-chemistry or a related field and at least 3-5years experience or an MS degree and 1-3 yearsof experience, thorough knowledge of specializedlaboratory instruments and familiarity with safespecimen handling practices. (Dept. MB-5)

* VIROLOGY SCIENTIST You will review andimplement specific R&D objectives involvingvirology. Additional responsibilities include viralinfectivity assays, process validation, evaluation ofantiviral agents, immunochemical and biochemicalassays in retrovirology and process development.To qualify, you must have a BS in Microbiology,Biology, Biochemistry or a related field and atleast 3-5 years experience, or an MS with 1-3years experience. Experience should encompassretrovirology or related lab discipline, backgroundin HIV-1 infectivity assays, familiarity with pro-cess validation and GLP and computer literacy.Excellent communication skills and strict inter-pretation and compliance with sterile techniqueand biohazard containment a must. (Dept. MB-10)

* IMMUNOLOGY SENIOR SCIENTIST Concen-trating in antibody-based infectious disease treat-ment, you will assist in developing new tech-nologies/products and processes. We requirea Ph.D. in Immunology or related discipline,or Master's degree with at least 2-5 years ex-perience in industrial research and develop-ment. You must have a thorough knowledge ofimmunologic and biochemical techniques withan emphasis on immunochemical characteriza-tion and structural and biologic function anal-

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ysis. We prefer individuals with experience inantibody affinity constant determination, andepitope/specificity mapping and molecularimmunology. Strong verbal and written commu-nication skills are essential. (Dept. MB-20)

* IMMUNOLOGY SCIENTIST Primary respon-sibilities include basic and applied research relatingto product support, and assisting with new tech-nology/product development and research effortsin the areas of infectious disease treatment. Thisposition will also support the implementationof monoclonal antibody technologies. We requirea BS in Immunology or a related field, and atleast 2-5 years experience in industrial R&D.Demonstrated expertise in techniques necessaryfor mammalian tissue culture, monoclonal anti-body production and ELISA/Western methoddevelopment essential. Must have good verbaland written communication skills. (Dept. MB-25)

* FORMULATIONS SCIENTIST This positioninvolves conducting research for developing newformulations technology, and assisting the managerin defining project objectives. Requirements in-clude a BS with at least 5-7 years experience, oran MS with 3-5 years in the area of formulations.Background in and understanding of the physical/chemical changes that occur during lyophilizationrequired. Working knowledge of basic proteinand drug delivery systems a must. (Dept. MS-01)

* CHARACTERIZATION SUPERVISOR Super-vising R&D activities in our characterization lab,you will develop analytical techniques/methods,and recommend project timelines, staff andbudget. We require a Ph.D. in Biochemistry/Ana-lytical Chemistry with at least 2-3 years in proteincharacterization and structure/function analysis.Proficiency in HPLC, carbohydrate analysis,amino acid analysis/sequences, CD, ORD, MMRand mass spectroscopy needed. (Dept. BF-50)

* CHARACTERIZATION SCIENTIST Respon-sibilities involve the development of methods formolecular characterization of proteins in processand final products, and scanning densitometryof gels. Methods include gel electrophoresis,isoelectric focusing and liquid chromatography ofcarbohydrates. A BS in Chemistry or Biochemistrycoupled with 5+ years experience or an MS re-quired. Knowledge of biochemical methods andfamiliarity with PCs important. Protein chem-istry experience desirable. (Dept. BF-60)

* PURIFICATION SCIENTISTS Opportunitiesinvolve developing new techniques and assaymethods for evaluating product purity, trainingthe research and production staff in new tech-niques, and interpreting and communicating ex-periment results. Senior positions will involvethe design/review of project objectives andassisting in timeline/budget projections. Werequire a Ph.D. or MS in Biochemistry or a BSwith 3+ years related experience. Knowledgeof protein purification, development of assaymethods, and GLP/GMP essential. Senior levelpositions require 3+ years industrial or post-graduate academic research experience with1+ years supervisory responsibility. Ability towork flexible hours important. (Dept. BF-70)

* Make Baxter-and sunny southern California-your place of choice. Enjoy year-round warmweather and the rewards of a Fortune 100 company,including a smoke free working environment, anattractive salary, and comprehensive benefits.Employment consideration contingent upon theresults of a drug screening test. For confidentialconsideration, please send your resume with salaryrequirements (please indicate appropriateDept.) to: Baxter, Hyland Division, HumanResources, 4501 W. Colorado Blvd., Los Angeles,CA 90039.We are an equal opportunity employer. U

Baxter

POSITIONS OPEN

FACULTY POSITION-ALBERT EINSTEINCOLLEGE OF MEDICINE, X-RAY CRYSTAL-LOGRAPHY. The Department of Biochemistry at theAlbert Einstein College of Medicine is seeking a facultymember with experience in solving biochemical prob-lems by x-ray crystallography for a tenure-track position.Faculty rank will be determined by prior experience. Acomplete protein x-ray crystallography laboratory includ-ing area detector and computer graphics is in operationand will be expanded to meet the needs of the candidate.Applicants should send curriculum vitae, names of threeor more references, and a summary of research interestsand future research plans to: Dr. Howard Steinman,Department of Biochemistry, Albert Einstein Collegeof Medicine, Jack and Pearl Resnick Campus, 130Morris Park Avenue, Bronx, NY 10461. Applicationswill be reviewed beginning 1 July 1990. The AlbertEinstein College ofMedicine ofYeshiva University is an EqualOpportunity/Affinnative Action Employer.

The Department of Animal Sciences, University ofArizona, invites applications for two tenure-track FAC-ULTY POSMIIONS. Areas of research could include,but are not limited to, reproductive biology, genetics,muscle or growth biology, or nutrition. Preference willbe given to individuals whose research complementsongoing departmental programs in cellular/molecularbiology. Ability to secure extramural funding is essential.Qualifications include a Ph.D. in a discipline of biologicalscience. A letter of application including area of interestand proposed direction of future research, a resume,transcripts, and names, addresses, and telephone num-bers of three individuals to provide references should besent to: Dr. Mark E. Wise, Search Committee Chair,Department ofAnimal Sciences, Shantz 228, Univer-sity of Arizona, Tucson, AZ 85721. Application reviewis 1 September 1990; will continue unti[position is filled.The University ofArizona is an Equal Opportunity/Affir-mative Action Employer. Women and minorities are urged toapply.

UNIVERSITY OF TENNESSEE, KNOXVILLEThe Department of Pathobiology, College of Veteri-

nary Medicine, University of Tennessee, has a tenure-track FACULTY POSITION available for a veterinarypathologist. The successful candidate will be expected todevelop a strong independent and collaborative researchprogram in cellular/molecular pathogenesis of diseaseand to participate in departmental teaching and serviceprograms. ACVP Board certification is desirable as isexperience in zoo or laboratory animal pathology. Aca-demic rank and salary will be commensurate with back-ground and experience. Applications will be reviewedbeginning 1 August 1990. Applicants should send cur-riculum vitae, letters of reference, and a statement ofcareer goals to: Dr. R M. Shull, Department ofPathobsology, College of Veterinary Medicine, P.O.Box 1071, Knoxville, TN 37901-1071. Telephone:615-546-9230, ext. 250.The University of Tennessee is an Equal Opportunity!

Affirmative ActionVTitle IX/Section 504 Employer.FACULTY POSITION

MOLECULAR GENETICSThe Department of Molecular Genetics of the Beck-

man Research Institute of the City of Hope invitesqualified candidates to apply for a tenure-track facultyposition at the ASSISTANT RESEARCH SCIEN-TIST level (equivalent to an assistant professor appoint-ment at a university). Candidates should have a Ph.D. orcombined M.D./Ph.D. degree and at least 2 years ofpostdoctoral experience. In particular, we are seekingapplicants with strong research backgrounds in molecu-lar or classical genetics as applied to problems in eukary-otic gene reguLation and/or DNA recombination.The Beckman Research Institute ofthe City ofHope is

a nonprofit, basic research facility affiliated with the Cityof Hope National Medical Center. The Department ofMolecular Genetics is part of the Division of Biology,which is comprised of 15 full-time faculty members.The campus is located in a suburban community in thegreater Los Angeles area and has convenient access tomajor academic and cultural centers of this region.Interested persons should send a letter of interest,curriculum vitae, statement of research interests, andthe names, addresses, and telephone numbers of threeprofessional references to: Dr. John J. Rossi, SearchCommittee, Department of Molecular Genetics,Beckman Research Institute of the City of Hope,1450 East Duarte Road, Duarte, CA 91010.

SENSORY SCIENCE FACULTY POSMONTenure track. Research and graduate teaching. Strong,

self-sustaining research program in an area of sensory/neural information processing essential. Rank and salaryopen. Send curriculum vitae, statement of goals, andnames of three references to: H. G. Sperling, TheUniversity of Texas Health Science Center at Hous-ton, Sensory Sciences Center, 6420 Lamar FlemingAvenue, Houston, TX 77030. Equal Opportunity Em-ployer. Women and minorities are encouraged to apply.

The Departnent of Botany, Tel Aviv University, isseeking applicants to fill two tenure-track positions atLECTURER/SENIOR LECTURER level in repro-ductive biology of higher plants, starting 1991-92, andin plant physiology starting 1992-93. Applicants arerequired to establish active research groups, have a Ph.D.in botany or related biological sciences, and have at least2 years of postdoctoral research experience. Applicantsshould submit a letter of application, curriculum vitae,and names and addresses of at least three professionalreferences by 30 September 1990 to: Professor D.Eisikowitch Search Committee, Department of Bot-any, Tel Aviv University, Tel Aviv 69978, Israel.

LECTURERMICROBIOLOGY, CELL AND

MOLECULAR BIOLOGY LABORATORIESDEPARTMENT OF BIOLOGY

THE UNIVERSITY OF MICHIGANThe Department of Biology at the University of

Michigan announces the availability of a nontenure-tracklecturer position. The term ofappointment is for a periodof 3 years and is subject to renewal based on satisfactoryperformance. The lecturer will serve as coordinator andsupervisor of instruction in upper-level laboratorycourses in microbiology and in cell and molecular biol-ogy. A relevant Ph.D. degree is required, along withexperience in teaching undergraduate courses in areassimilar to microbiology and cellular and molecular biol-ogy. In addition to general supervisory matters, dutieswill include working with faculty to update laboratoryexperiments and training of graduate student teachingassistants who serve in the laboratories. Appointmentsare on a 12-month basis and include a liberal benefitspackage: This position is available 1 January 1991, andthe deadline for receipt of applications is 1 September1990. Applicants should provide curriculum vitae andthree letters of recommendation to:

Dr. Robert BenderDepartment of Biology

The University of AEchganAnn Arbor, MI 481091048

The University of Michigan is an Equal Opportunity!Affirmative Action Employer.

GEOPHYSICS

Scripps Institution of Oceanography of the Universityof California at San Diego (UCSD) invites applicationsfor tenured or tenure-track positions in global seismol-ogy, geomagnetism, or theoretical geophysics. The levelof appointment(s) will depend upon the qualifications ofthe candidate and the salary wilt be based upon the payscale of the University of California. Candidates for thelevel of ASSISTANT PROFESSOR will be expectedto show evidence of their potential through a publicationrecord appropriate for their experience and letters ofrecommendation; candidates for ASSOCIATE ORFULL PROFESSOR must show evidence of a strongresearch record. Applicants must hold a Ph.D. (or equiv-alent) degree at time of appointment. Applicationsshould include the names of five references and curricu-lum vitae giving teaching and research experience, andshould be addressed to: Chairman, Geophysics SearchCommittee, A-008, Scripps Institution of Oceanog-raphy, UCSD, La Jolla, CA 92093. Applications re-ceived after 1 October 1990 may not be considered.UCSD is an Equal Opportunity/AfrmativeAction Employer.

THE SCHOOL FOR FIELD STUDIESMARINE MAMMALOGISTS (two): Baja, Mexico.

Teach marine mammal biology/ecology and superviseresearch in semester programs. Desired qualifications:Ph.D., research in Baja, experiential teachmg, Spanish.Nine-month position. Year option. Start August 1990.

Send letter, curriculum vitae, and three references withtelephone numbers to: S-Search, School for FieldStudies, 16 Broadway, Beverly, MA 01915.

I678

HEALTH SCIENTISTThe Environmental Criteria Assessment Office

(ECAO) ofthe Environmental Protection Agency (EPA)is seeking candidates for health scientist positions, GS11-13 ($29,891 to $55,381 per year, based on qualifi-cations), located at Research Triangle Park, North Caro-lina. The principal duties include performance or supportof health hazard assessments for air pollutants, includingthe development of inhalation reference doses; researchto improve the scientific bases of risk assessments ofinhaled chemicals; and technology transfer to state andregional agencies. Only U.S. citizen are eligible. Theessential qualifications include an advanced degree intoxicology or a closely related biological discipline suchas pharmacology, physiology, biochemistry, or Immunol-ogy (equivalent experience may be substituted); a mini-mum of 1 year of professional experience as a principalinvestigator in toxicology or health risk assessment re-search; and publications and presentations at nationalscientific meetings on toxicology or health risk assess-ment. Expertise in inhalation toxicology, metal toxicol-ogy, immunotoxicology, pharmacokinetics, or epidemi-ology is desirable, but not required. Please submit SF-171 and supporting documentation by 27 July 1990 to:Dr. Chon Shoaf, c/o Dorothy Carr, EPA MD-29,Research Triangle Park, NC 27711. For further infor-mation, call: Dorothy Carr, 919-541-0074. EPA is anEqual Opportunity/Afirmative Action Employer.

HEMATOLOGISTOR CLINICAL BIOCHEMIST

Tenure-track position at Michigan State University.Requires Ph.D. in appropriate field of study, nationalcertification, and experience in clinical laboratory sciencesor specialty. Strong commitment to teaching and re-search is essential. Review of applicants wil begin 1October 1990. Send curriculum vitae, four letters ofreference, and a statement of research and teaching goalsto: N. Barratt, Ph.D., Medical Technology Program,E-37 McDonel Hall, Box 3, East Lansing, MI 48825.

MOLECULAR BIOLOGISTPACIFIC NORTHWEST

RESEARCH FOUNDATIONSEATTLE, WASHINGTON

Applications are invited for a research staff position atthe ASSISTANT, ASSOCIATE, OR PROFESSORlevel in a multidisciplinary research laboratory. Housedin a new 45,000-square-foot facility in scenic Seattle,research programs include immunology, toxicology, andbiochemistry, with more specific programs in AIDS andcancer research. Candidates must have demonstratedexceptional research ability in dynamic areas of molecularbiology with an independent research program as well asa record of peer-reviewed grants and research publica-tions. Preference will be given to individuals who haveexpertise and commitment in the area of molecularbiology, more specifically that related to cancer and/orgenetic disorders. The Pacific Northwest Research Foun-dation provides competitive salaries and benefits, a stim-ulating research environment, and opportunities for in-teraction with faculty at nearby institutions. Interestedapplicants should send complete curriculum vitae, thenames of three recent references, and a briefstatement ofresearch interests to: WVilliam B. Hutchinson, M.D.,Director, Pacific Northwest Research Foundation,720 Broadway, Seattle, WA 98122. Telephone: 206-726-1210. FAX: 206-726-1217.An Equal Opportunity!AffirmativeAction Employer.

MOLECULAR IMMUNOLOGISTCandidates are sought at the ASSISTANT or ASSO-

CIATE PROFESSOR level, tenured or tenure track, toundertake research using molecular approaches to immu-nology. Candidates are expected to establish a vigorousresearch program and participate in graduate studenteducation. The closing date for receipt of inquirie si1August 1990. Please send curriculum vitae and names ofthree references to: Search Committee, Department ofPathology and Laboratory Medicine, 709 WoodruffMemorial Building, Emory University School ofMedicine, Atlanta, GA 30322. Emory University is anEqual Opportunity/Afimrative Action Employer.

SCIENCE recruitment ads reach thousands of scien-tists in all disciplines, worldwide. Classified Advertisingtelephone: 202-326-6555. FAX: 202-682-0816.

SCIENCE, VOL. 24.8

POSITIONS OPEN POSITIONS OPEN

nvestigate a Careerwith a Leader.Searle, a world-wideleader in the pharma-ceutical industry, in-vites you to investigatea career with us as aSenior Research Investi-gator. We are currentlyseeking such a profes-sional for our DrugMetabolism Depart-ment.

The individual in thisposition will be respon-sible for developing,validating and transfer-ring bioanalyticalmethods, indudingimmunoassays andspecial chemistries, fornaturally occurringconstituents. In addi-tion, the candidate weselect will supervise allactivities associatedwith maintaining aneffective and produc-tive BioanalyticalImmunoassay/ SpecialChemistry Laboratory.

We require a profes-sional with a Ph.D. inBiochemistry, or a relat-ed field. Additionally,2-3 years experience inimmunoassay and re-ceptor binding methoddevelopment is requir-ed, and establishedsupervisory skills aredesirable.

All the evidence pointsto Searle for a success-ful career. For consider-ation, please send yourresume, in confidence,to:

Searle, HumanResources, Dept. PB3,4901 Searle Pkwy.,Skokie, IL 60077.

An equal opportunityemployer M/F/H

STEaRLETogether, we can do a world of good.

DEPARTMENT OF NUTRITIONAL SCIENCESUniversity of Connecticut

The Department of Nutritional Sciences at the University ofConnecticut is seeking applicants for the following anticipatedpositions:DEPARTMENT HEAD/PROFESSOR-(Search Reopened).Candidates should have strong distinguished teaching and re-search record as the department has a strong teaching and a well-funded interdisciplinary research program. Responsibilities in-clude providing initiative and vision to departmental developmentand administering teaching, research and extension. Contact:Gretel Pelto, Ph.D., Chair, Search Committee. Phone (203) 486-1783. (Search #OA271).ASSISTANT PROFESSOR (9-month, tenure-track). Qualifica-tions include a Ph.D., M.D., D.PH. or equivalent degree. Post-doctoral experience preferred. Candidates who have studiedhuman metabolism using techniques such as stable isotopes,molecular biology or nutritional epidemiology are encouraged toapply. Responsibilities include research and teaching at theundergraduate and graduate levels. Send CV, transcripts, adescription of research plans and contact information for threereferences to: Carol J. Lammi-Keefe, Ph.D., Chair, SearchCommittee. Phone (203) 486-0116. (Search #OA272).Interested applicants should send information to the contactperson indicated above at The University of Connecticut, Depart-ment of Nutritional Sciences, U-17, Storrs, CT 06269-4017.Closing date for application is August 1, 1990.

The University of Connecticut is an Affirmative Action/Equal Opportunity Employer.

THENIVERSITY OF

flCONNECTICUT

Mrd,( GLAXO INSTITUTE FOR MOLECULAR BIOLOGY

The Geneva molecular biology research institute of one of the world's most successful healthcare groups is recruiting

MOLECULAR BIOLOGISTSto identify and isolate novel genes

Two positions are available. The successful candidates will have leading roles in two different project groups. One groupis investigating the molecular biology of neurotransmission on several levels from receptor to cellular response. Thesecond project group is working to understand the molecular mechanisms underlying signalling through cell-cell contact.Experience with direct expression cloning and expression of cDNA sequences in mammalian cells would be a distinctadvantage. The ideal candidates will have a PhD and a proven track record of research.

The Glaxo Institute for Molecular Biology carries out long term research to support the company-wide effort to discovereffective new medicines. It provides a dynamic research environment, and encourages the publication of scientificresults as well as collaborative projects with academic groups.

We offer an excellent salary and benefits package and opportunities for career development in one of the most attractiveparts of Europe.

If you are interested in one of these positions, please send your Curriculum Vitae with a list of publications and the namesof three referees to:Rita Gloor, Personnel Manager, GLAXO IMB S.A., 46, route des Acacias, 1211 Geneva 24, Switzerland.

_Mmr.

I

POSITIONS OPEN

PHARMACOKINETICIST. To design and executeprotocols for clinical trials of drug products. Conductpharmacokinetic and statistical data analyses of results ofclinical trials. Lending scientific support for analysis ofdrug products in biological fluids. Will prepare reportson results for IND andNDA for submission to the FDA.A Ph.D. with minimum of 2 years of postdoctoral workexperience (in a pharmaceutical industry) required in thedesign, modification, and use of pharmacokinetic andanalytical research methods (including modeling).Knowledge of FORTRAN and statistical analyses re-

quired. Salary for 5 days, approximately 40 hours perweek: $46,000 per year. Mail r6sume and copy of thisadvertisement to: Department of Economic and Em-ployment Development, 1100 North Eutaw Street,Room #212, Baltimore, MD 21201. Job Order No.8944457. Job location: Rockville, Maryland. Proof oflegal right to work in the United States required.

PLANT TISSUE CULTURE. The Land, EPCOTCenter, is seeking to fill a position in plant cell and tissueculture. Responsibilities include the application and de-velopment of regeneration techniques for a wide varietyof food crop species, routine clonal propagation of amerchandised tissue culture product, and laboratorymaintenance. Requirements include an M.S. degree andan excellent ability to work with people. Please sendresume and three letters of recommendation to: Mr.Paul Buss, Professional Staffing, Walt Disney WorldCompany, P.O. Box 10090, Lake Buena Vista, FL32830.

PHYSICIANS WANTEDAn international organization is currently seeking

medical staff for a new children's hospital to be located inKiev, U.S.S.R., that will study the multiple after-effectsof the Chemobyl accident. Pediatric physicians withspecial qualifications in endocrinology, hematology, andimmunology are required immediately. Other subspecial-ties will be required before the end of 1990. Contractualperiods of service for 1 year are desired but shorterperiods will be considered. Salary is negotiable and willbe paid in U.S. dollars. Knowledge of Ukrainian or

Russian is not essential.Reply to: Box 65, SCIENCE.

POSTDOCTORAL POSITION

Available immediately to study spinal and supraspinalfactors regulating the activity o sympathetic pregangli-onic neurons. A variety of neurophysiological and neu-roanatomical techniques will be used. Experience inextracellular single-unit recording preferable. Contact: L.P. Schramm, Department ofBiomedical Engineering,The Johns Hopkins School of Medicine, 226 TraylorBuilding, 720 Rutland Avenue, Baltimore, MD21205-2195.

POSTDOCTORAL POSITION INDEVELOPMENTAL NEUROPHYSIOLOGYPosition available for fall of 1990 to study changes in

electrical and pharmacological properties of spinal mo-toneurons during embryonic development and after in-jury. Experiments are conducted using isolated spinalcords of rat embryos and spinal cord-muscle explants inorgan culture. Send curriculum vitae and three letters of

erence to: Dr. Lea Ziskind-Conhaim, Departmentof Physiology, University of Wisconsin, 1300 Uni-versity Avenue, Madison, WI 53706. Telephone:608-263-3382. FAX: 608-262-2327.

POSTDOCTORAL POSITIONMOLECULAR PLANT VIROLOGY

Applications are invited for a postdoctoral position inthe applied molecular biology section, Plant BiologyDivision, of the Samuel Roberts Noble Foundation. Theposition will be for 3 years and is available immediately.We are looking for motivated applicants with back-grounds in molecular virology and/or molecular biology.Projects include (i) identifying the symptom determi-nants of an infectious cDNA clone from an attenuatedstrain of tobacco mosaic virus and (ii) implementingnovel molecular approaches for the production of virus-resistant crop plants. Please send a resume and a list ofthree references to: Dr. Richard Nelson, Plant BiologyDivision, Samuel Roberts Noble Foundation, P.O.Box 2180, Ardmore, OK 73402. FAX: 405-221-7362. The position will be open until filled.

i68o

POSITIONS OPEN

Two POSTDOCTORAL POSMIONS are availableto study the gene expression of proteoglycans in humancolon cancer and cancer cells. These studies are anintegral part of two recently funded NIH grants. Salaryrange: $20,000 to $25,000, dependent on experience.Candidates should have a Ph.D./M.D. with strong back-ground in molecular biology and biochemistry. Sendcurriculum vitae and names, addresses, and telephonenumbers of three references to: Rento V. Iozzo, M.D.,Department of Pathology and Cell Biology, ThomasJefferson University, Room 249, Jefferson AlumniHall, Philadelphia, PA 19107-6799. Telephone:215-955-2208. FAX: 215-923-2218. Equal Opportu-nity Employer.

POSITIONS AVAILABLE, POSTDOCTORALthrough ASSISTANT PROFESSOR level. Geneexpression and structure in colon cell differentiation andtransformation. Forward resume and names of referencesto: Leonard H. Augenlicht, Ph.D., Molecular Oncol-ogy Program, Albert Einstein Cancer Center, Mon-tefiore and Albert Einstein Medical Centers, 111 East210th Street, Bronx, NY 10467.

POSTDOCTORAL POSITION available, Univer-sity of Florida. Support is available for an individual witha Ph.D., or equivalent degree, in biochemistry, molecularbiology, immunology, or microbiology to pursue sub-unit vaccine development for the rickettsial parasite,Anaplasma marginale. Parasite surface proteins involved ininvasion of host erythrocytes will be identified, cloned,and characterized, and recombinant products based onthese surface proteins will be isolated and tested for theirimmunoprotective efficacy in cattle. Interested individu-als should send curriculum vitae, statement of researchgoals, and three letters of reference to: Dr. David R.AlUred, Department of Infectious Diseases, Building471, Mowry Road, IFAS 633, University of Florida,Gainesville, FL 32611. The University of Florida is an

Equal Opportunity/Affirmative Action Employer.

POSTDOCTORAL POSITION IN MOLECU-LAR NEUROBIOLOGY. For studies of nicotinicacetylcholine receptors and related proteins. Graduate orpostgraduate experience with hybridomas, monoclonalantibodies, and protein purification is required. You willwork closely with postdoctoral researchers experiencedwith molecular genetics, and, to some extent, cross-trainone another. Research will be conducted at the Institutefor Neurological Sciences at the University of Pennsyl-vania in Philadelphia. Send curriculum vitae and names,addresses, and telephone numbers of at least three refer-ences, including your current mentor, to: Dr. Jon Lind-strom, The Salk Institute, P.O. Box 85800, SanDiego, CA 92138-9216.

POSTDOCTORAL SCHOLAR, 100% time,$18,000 per year. Postdoctoral position available to investi-gate posttranslational lipid modification of keratin-ocyte enzyme. Recent Ph.D. in biochemistry and at least1 year of experience in keratinocyte culture, HPLC, fattyacid biosynthetic pathways in animals, isolation of en-zymes from epidermal tissues, immunochemical tech-niques, and peptide chemistry required. Should havepublication record in intemational journals and ability towork independently. Place of employment and inter-views: Davis, California. Send this ad and your resumeto: Job #BLW15379, P.O. Box 9560, Sacramento,CA 95823-0560, no later than 14 July 1990.

A POSTDOCTORAL POSMIION in forest soils/hydrology is available immediately to plan and conductstudies in forest ecosystem recovery and restorationresearch related to the effects ofhurricane Hugo. Focus ison stream and groundwater quality and treatments toenhance vegetation recovery. Applicant must be a U.S.citizen and have a Ph.D. with a strong background inforest soils and hydrology. Familiarity with watershedresearch techniques, soil and water analytical techniques,and principles of plant ecology are desirable. Position islocated at the U.S. Department of Agriculture ForestService, Forestry Sciences Laboratory, Charleston, SouthCarolina; research site is the Santee Experimental Forestnear Huger, South Carolina. Initial appointment is notto exceed 2 years but may be extended for an additional2 years, if necessary. Salary is $35,825. Please sendcurriculum vitae and Application for Federal Employ-ment SF-171 to: Nathan Presley, Personnel Section,Southeastern Forest Experiment Station, P.O. Box2680, Asheville, NC 28802. Deadline for applicationsis 1 August 1990.

POSITIONS OPEN

POSTDOCTORAL POSITION. A postdoctoralposition is immediately available to study mechanisms ofchemical carcinogenesis at the molecular level. A candi-date with skills in molecular cloning is desired forresearch involving the identification and cloning of novelmammalian transforming genes (oncogenes, tumor sup-pressor genes). EHRT, Inc., is an established, expandingsmall business located in Research Triangle Park, NorthCarolina, and provides excellent benefits and competitivesalary. For further information, contact: Jessica A. Las-ley, Project Leader, P.O. Box 12199, Research Tri-angle Park, NC 27709.

COGNITIVE NEUROPHYSIOLOGY POST-DOCTORAL POSMONS. To identify synaptic path-ways generating cognitive potentials during memory andlanguage tasks using (i) magnetoencephalography (twoposts in Rennes, France); (ii) human depth electrodes(temporal, parietal, and frontal; one post in Rennes); or(iii) primate hippocampal recordings (one post in LosAngeles). Please send a letter, curriculum vitae, and threereferences to: Eric Halgren, Ph.D., BRI 73-364 CHS,University of California 176118, Los Angeles, CA90024. Equal Opportunity Employer.

POSTDOCTORAL POSITIONS. Available imme-diately in an NIH-supported postdoctoral training pro-gram to study (i) the structure/evolution of the albumin-AFP-DBP gene family [see PNAS 86, 9360-9364(1989)] with Professor Achilles Dugaiczyk and (ii) cel-lular and molecular regulation of B lymphopoiesis [seeAnnu. Rev. Immunol. 8, 111-137 (1990)] with ProfessorKen Dorshkind. Applicants must be U.S. citizens or perma-nent residents. Contact: Program Director, Division ofBiomedical Sciences, University of California, River-side, CA 92521. An Affirmative Action/Equal OpportunityEmployer.

POSTDOCTORAL FELLOWSHIPThe Oregon Regional Primate Research Center

(ORPRC) is pleased to announce the availability of a2-year postdoctoral fellowship ($18,000 salary per yearplus fringe benefits), as weU as a $5,000 aboratoryallowance per year to support research in the laboratoryof a center scientist. Approximately 30 ORPRC staffscientists conduct research in the Divisions of Reproduc-tive Biology and Behavior, Neuroscience, and PrimateMedicine. Research approaches range from molecularand cell biology through whole animal physiology. Ap-plicants must be U.S. citizens or havepermanent residency statusin the United States. A formal application in conjunctionwith a staff scientist must be submitted on an NIHPHS-398 form by 1 December 1990. Funding can beginon 1 January 1991.

For a complete list of scientists, research programs, andother information concerning ORPRC, please contact:

Office of the DirectorOregon Regional Primate Research Center

505 N.W. 185th AvenueBeaverton, OR 97006

The ORPRC is an Equal Opportunity/Affirmative ActionEmployer.

YALE UNIVERSITYPOSTDOCTORAL TRAINING FELLOWSHIP

MEDICAL PHYSICSThe Department of Therapeutic Radiology at Yale

University School of Medicine seeks applications for theposition of a postdoctoral fellow. Principal area of re-search is the physics of radiation therapy. Current areasinclude radiation dosimetry, development ofnew sourcessuch as americium-241 and palladium-103 for novelapplications in brachytherapy, Monte Carlo simulationsof radiation effects at macro- and micro-levels, super-heated drop detectors for neutrons, and biophysicalaspects of radiobiology. This postdoctoral training posi-tion is funded by the National Cancer Institute (NCI)and is meant for a Ph.D. in physics who is interested inpursuing a research career in developing applications ofphysics to cancer causation, prevention, diagnosis, andtreatment. The salary provided by the NCI ranges from$20,000 to $34,000 per annum depending upon previ-ous research experience. The position is for 2 years.Applicants must be U.S. citizens or have a pemnanent visastatus. Send curriculum vitae to: Ravinder Nath, Ph.D.,Professor, Department of Therapeutic Radiology,Yale University School of Medicine, 333 CedarStreet-HRT #221, New Haven, CT 06510.

Yale University School ofMedicine is an Equal OpportunitylAffirmative Action Employer.

SCIENCE, VOL. 248

POSITIONS OPEN

POSTDOCTORAL FELLOWSHIP. Immediateopening for a 2-year position studying transcriptionalregulatory mechanisms in baculoviruses. The candidatemust have Ph.D. and a strong background in molecularbiology. Experience in animal cell tissue culture wouldalso be an asset. Salary is $32,239 including benefits.Send curriculum vitae and names of three references to:Dr. David A. Theilmann, Agriculture Canada Re-search Station, 6660 N.W. Marine Drive, Vancouver,B.C., Canada V6T 1X2. FAX: 604-666-4994.

MOLECULAR NEUROBIOLOGY POSTDOC-TORAL FELLOWSHIP. To study the molecular basisof synaptogenesis, neural circuitry formation, nerve re-generation, and pathogenesis of medically importantneuropathies. Research insulin-like growth factor geneexpression and neurotrophic effects (see Proc. Nad. Acad.Sci. U.SA. 86, 2898; Molec. Brain Res. 6, 109) underNIH grants. Domestic/foreign applicants equally wel-come. Submit curriculum vitae with names and tele-phone numbers of three references to: Professor Dou-glas N. Ishii, Physiology Department, Colorado StateUniversity (CSU), Fort ColEins, CO 80523. CSU is anEqual Opportunity/Affirmative Action Employer.

POSTDOCTORAL FELLOW POSMONS. Inneuroscience at the Addiction Research Center. Topicsof research include: characterization and purification ofdrug and neurotransmitter receptors, cocaine receptors,neurotransmitters of reward and addiction, and effectsof drugs on neurotransmitter systems. Salaries rangefrom $29,000 to approximately $49,000 depending onexperience and qualifications. Benefits and relocationexpenses may be available. Previous postdoctoral experi-ence desirable but not necessary. Send curriculum vitaeto: Dr. Michael J. Kuhar, NIDA Addiction ResearchCenter, P.O. Box 5180, Baltimore, MD 21224. TheAkohol, Drug Abuse, and Mental Health Administration(ADAMHA) is an Equal Opportunity Employer.ADAMHA is smokefree and drug free.

VICTORIA UNIVERSITY OF WELLINGTONNEW ZEALAND

UGC POSTDOCTORAL FELLOWSHIPIN CHEMISTRY

Applications are invited for a postdoctoral fellow toundertake research on a project designed to developimproved processes for selectively removing metals, ascations, from solution. Address inquiries to: ProfessorN. F. Curtis or Dr. G. R. Burns, Department ofChemistry.The fellowship is tenable for 2 years and carries an

annual salary of $NZ35,500. A limited travel grant isavailable. Conditions of appointment and method ofapplication available from: Appointments Administra-tor, Victoria University ofWellington, P.O. Box 600,Wellington, New Zealand (FAX: 04-711-700), withwhom applications close on 17 August 1990.

The University is an Equal Opportunity Employer.

HARVARD MEDICAL SCHOOLDEPARTMENT OF DERMATOLOGY

POSTDOCTORAL TRAINING PROGRAMFOR Ph.D.'s

The research program is supported by an NIH traininggrant and participants spend a minimum of 2 yearsengaged in basic research under the supervision of ourfaculty. The WeUlman Laboratories of Photomedicine aswell as the newly established Cutaneous Biology Re-search Center provide additional opportunities for fruit-ful research careers.

The Harvard Medical School Department ofDermatology isa committed Equal Opportunity/Affirmative Action Employer.Minorities, women, handicapped, and veterans are encouraged toapply.

Inquiries to: Howard P. Baden, M.D., ProgramDirector, Department of Dermatology, Massachu-setts General Hospital, Boston, MA 02114.

POSTDOCTORAL FELLOW/RESEARCH AS-SOCIATE. Position available for Ph.D. or equivalent tostudy the role of erythrocyte-endothelial interaction inthe pathogenesis of vascular disease. Emphasis on sicklecell anemia and related disorders. Background in molec-ular or cell biology or biochemistry preferred. Sendcurriculum vitae and references to: Dr. Robert Wein-stein, Department of Biomedical Research, St. Eliza-beth's Hospital of Boston, 736 Cambridge Street,Boston, MA 02135. An Equal Opportunity Employer.

29 JUNE 1990

Sandoz Pharmaceuticals Corporation is responsible for products that improve the qualityof life. Our developments are the result of research conducted by professionals who

specialize in many different fields.

The Sandoz Research Institute has an opening for a Postdoctoral Scientist to work in ahighly interdisciplinary setting using molecular biology, biochemistry, and molecularmodeling to explore, at a molecular level, the mechanisms of enzyme action. Theresearch area will focus on targets in lipoprotein metabolism and atherosclerosis as partof an overall effort to develop novel therapeutics in these areas. The candidate is

expected to serve as a bridge between disciplines, designing projects in collaborationwith the molecular biology, chemistry, and molecular modeling groups. This is a one-year,industry-based position which may be extended up to two years by mutual agreement.

The successful candidate will have a Ph.D. in Biochemistry, Molecular Biology, Bio-

Organic Chemistry, or the equivalent with 0-3 years of postdoctoral experience. Experi-ence with molecular biological and biochemical approaches to understanding structure/function relationships of enzymes, and working knowledge at a molecular level of

enzymatic reaction required. Some experience with essential computational chemicaltools for studying proteins and/or peptides would be preferred.

Positions at Sandoz offer personal satisfaction, professional opportunity/challenge, com-petitive salaries and an excellent benefits package. Our campus-like facilities are con-

veniently located in northern New Jersey.

For prompt consideration, please send a curriculum vitae, a list of professional referencesand a brief summary of prior research experience, to:

SANDOZ

Department of Human Resources (403/1)SANDOZ RESEARCH INSTITUTE

SANDOZ PHARMACEUTICALS

CORPORATIONEast Hanover, New Jersey 07936

An Equal Opportunity Employer M/F/H/V

MOLECULAR EVOLUTIONCOLORADO STATE UNIVERSITY

The Department of Biology invitesapplications for a full professor to initiate aprogram in Molecular Evolution. The personselected must have a Ph.D., a fully fundedresearch program, and experience and ascholarly record commensurate with fullprofessorship. It is required that thecandidate have a strong background in celland molecular biology and use currentmethodologies to elucidate evolutionaryrelationships among a broad spectrum oforganisms: protists, fungi, prokaryotes,plants, & animals. Teaching responsibilitieswill be to participate in courses such asevolution, molecular genetics, and molecularbiology, and in graduate education. Salarycommensurate with qualifications. Startingdate about 1 January 1991. Applicants areasked to send a resume, reprints ofrefereed papers, and three letters ofreference. Closing date: 30 July 1990.Send applications to: William C. Marquardt,Chair, Molecular Evolution SearchCommittee, Department of Biology,Colorado State University, Fort Collins, CO80523 USA

CSU is an AA/EOE Employer. EqualOpportunity Office, 314 Student ServicesBldg.

BRANCH CHIEFPharmaceutical and RegulatoryAffairs Branch, TreatmentResearch Program, Division ofAIDS, National Institutes ofAllergy and Infectious Diseases,NIH is seeking an experiencedscientist with a diverse medicaland pharmacological background.Requirements include: experi-ence with drug developmentprojects; knowledge of FDAregulations and procedures;experience in clinical trials andprotocol management; MD/PhD or

equivalent relevant experience.Position involves significantinteraction with pharmaceuticalcompanies, the FDA, and othercomponents of NIH. ImmediateOpening. Salary commensuratewith experience and training.Send CV and/or Application forFederal Employment (SF-1 71) to:

DAIDS/TRP/PRAB Room 202N6003 Executive BoulevardBethesda, Maryland 20892

U.S. Citizenship RequiredNIH is an Equal Opportunity

Employer

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I

GlenroseRehabilitationHospital

The Glenrose Rehabilitation Hospital is aleading facility in Canada dedicated toproviding excellence in patient care, researchand education in rehabilitation for bothchildren and adults. In the spring of 1990,we will be moving into a new building andwnumbe taking that opportunity to introduce anumber of new Initiatives.

Department ofRehabilitation TechnologyThis department will focus on the research,development and clinical application oftechnology, and engineering methods inrehabilitation. We are seeking an energetic,results-oriented person to establish thisdepartment as a leader in rehabilitationtechnology.Interested applicants should possess a postgraduate degree in a recognized engineeringdiscipline with preference given to those withexperience In rehabilitation or biomedicalengineering. The successful candidate willdemonstrate good communication skills,creativity and a strong Interest In Improvingthe quality of life for disabled people.Interested applicants are asked to forwardtheir curriculum vitae, references and salaryexpectations to:

Ms. K. CookActing Director of PersonnelGLENROSE REHABILITATION

HOSPITAL10230- 111 AvenueEdmonton, Alberta

CanadaT5G 0B7

THE MIAMI P TOJECOT CURE PALYSIS

Research Associate/Postdoctoral positions areavailable in an integrated, multidisciplinary re-search group focusing on anatomical, cellular,molecular, electrophysiological, and functionalcorrelates of spinal cord injury (SCI) and repairmechanisms. Specific areas of research include:Schwann cell and central neuroglial cell biology,including their role in regeneration after SCI andtransplantation (R. Bunge, M. Bunge, N. Kleit-man, P. Wood); plasticity, repair, and behavioralrecovery of motor and autonomic pathways (V.Holets); pharmacology of acute SCI and ische-mia (A. Martinez); molecular biological ap-

proaches to CNS regeneration (S. Whittemore);anatomical and functional plasticity of spinal so-matosensory pathways (R. Yezierski); recovery

of locomotor function following SCI (J. Kim), andclinical neurophysiology of SCI (B. Calancie).Send curriculum vitae and names of 3 referencesto Dr. Richard Bunge, Scientific Director, TheMiami Project to Cure Paralysis, University ofMiami School of Medicine, 1600 N.W., 10th Ave.(R48), Miami, FL 33136. The Miami Project is anEqual Opportunity/Affirmative Action Employer.

M1| !UNIVERSITY OF

SCHOOL OF MEDICINE

POSTDOCTORALRESEARCH ASSOCIATES

Capital District Center forDrug Abuse Research andTreatment (CDCDART)

The CDCDART, in the Albany area of northeasternNew York, is a new multidisciplinary consortium ofsixteen investigators from three institutions: the Rens-selaer Polytechnic Institute (Department of Chemistry:S. Archer, A. Schultz; Department of Psychology: L.Reid), the Albany Medical College (Department ofPharmacology and Toxicology: S. Glick, L. Hough, A.Schneider, M. Teitler, R. Mankes, J. Carlson, R.Keller), and the State University of N.Y.School ofPublic Health (Department of Environmental Healthand Toxicology: D. Carpenter, W. Shain, A. DeCaprio,R. Seegal, A. Snyder-Keller, R. Waniewski). Thefocus of the CDCDART is the development of newpharmacotherapies for drug abuse. The research pro-gram includes a broad range of biomedical technolo-gy, including medicinal chemistry, receptor and bio-chemical pharmacology, analytical neurochemistry,morphological toxicology, in vitro and in vivo neuro-physiology, and behavioral pharmacology. We haverecently received a grant from the Aaron DiamondFoundation to provide research training for threepostdoctoral research associates. These positions willbe funded for up to three years; the stipend is $25,000for the first year (inflationary increases for years 2 and3). It is anticipated that one postdoctoral researchassociate will be located at each of the three memberinstitutions. These positions are available immediate-ly. For further information, contact one of the follow-ing: S. Glick (518 445-5303), S. Archer (518 276-6339), D. Carpenter (518 458-6772). To apply, sendcurriculum vitae and three letters of reference to:Administrative Director, CDCDART, c/o Department ofPharmacology and Toxicology (A-136), Albany Medi-cal College, Albany, N.Y. 12208. Equal OpportunitylAffirmative Action Employer.

Faculty Positions In

The Biotechnology Center, in collaboration with academic depart-ments within the colleges of Biological Sciences, Medicine andPharmacy, invites applications for three joint tenure track facultypositions. Successful candidates will occupy new laboratories onthe Neurobiology floor of the Biotechnology Center and join exist-ing faculty whose research efforts focus on gene expression in ner-vous tissue during development and aging. This group will shortlyexpand to 10 faculty.Applicants for Assistant Professorships should demonstrateexceptional potential to develop strong research programs thatapply tools of molecular biology to address significant problems inneurobiology. Senior candidates with ongoing programs of excel-lence will be considered for an Associate Professorship. Qualifiedmolecular neurobiologists working with vertebrate or invertebratesystems will receive careful consideration. Candidates who utilizetransgenic mice in the course of their research are especiallyencouraged to apply.The Ohio State University is establishing an outstanding programin molecular neurobiology and neuroscience which is reflected byquality research facilities and highly competitive start-up fundsand salary.Screening of candidates will begin on August 15, 1990. Applicantsshould submit a curriculum vitae, statement of research plans, and

names and addresses of threev v ; ; .* x ; ^;references to Dr. Anthony Young,Chairperson, Molecular Neuro-

THE biology Search Committee, OhioState Biotechnology Center,

HIIO Rightmire Hall, 1060 CarmackRd., Columbus, OH 43210. The

STATE Ohio State University is an EqualOpportunity/Affirmative ActionUNIVERSITY Employer.

We'll Help You BuildA New Lab

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Let the free Science product informa-tion service put you in touch with the ven-dors whose products you will need.

Simply write us a letter stating thespecifics about your proposed lab and theinstruments and supplies you need. We willdo the rest. Write to:

SCIENCE MagazineNew Lab Service Department1515 Broadway Sc . ThPGllWMklyOlRe5lrCMNew York, NY 10036 CIENCE

.l

iS'- 4l ~NCOLD SPRING HARBOR LABORATORY FACULTY OF MEDICINE

SIX FACULTY POSITIONS_ MOLECULAR NEUROBIOLOGY | | | UNITED ARAB EMIRATES UNIVERSITYWe seek applicants for six new facultypositions in the fields of vertebrate and Applications are invited for appointment at Assistant, Associate andfull Professorial rank In the Department of Pharmacology (Clini-invertebrate Molecular Neurobiology. cal, Toxicology).This new area of research at ColdSpring Harbor Laboratory will Candidates must possess a medical degree and/or PhD degree or anSompring nt the long standing program

equivalent higher professional degree from an accredited university orcomplement the long standing program institution of higher learning, or any higher professional certificate suchof courses and lectures in neuroscience as Membership or Fellowship in the Royal College of the UK, Ireland,held at the Laboratory each Summer. Canada, Australia and New Zealand (MRCP, FRCS, MRC Path, MRCThe successful applicants will occupy Psych., FFARCS, MRCOG, FRCR), or the certificate of the Americanthe new Beckman Neuroscience Board or the Arab Board for Medical Specializations. The language ofBuilding which is scheduled for instruction is English.completion in mid 1991. Both senior Candidates for these positions must be able to demonstrate leadershipand junior faculty positions will be experience in the development of teaching, research and, whereconsidered. appropriate, clinical service programmes.Curriculum vitae, and brief statement of Persons interested in additional information on applying should send aresearch interests and names of curriculum vitae including list of publications, copies of certificates andreferences should be submitted to: the names of three current referees to:

Dr. Bruce Stillman Joel H. Lanphear, Ph.D.Cold Spring Harbor Laboratory Associate DeanP.O. Box 100 Faculty of MedicineCold Spring Harbor, NY 11724 UAE UniversityPO Box 17666

Al Ain

Cold Spring Harbor Laboratory | ||United Arab Emirates

0 Cold Spring Harbor Laboratory Fax No: 971 3 638247An equal opportunity/affirmative action employer. Applications will be closed six weeks after date of publication or

September 15, 1990 whichever occurs first.

Research Opportunities InENZYME STRUCTURE AND MECHANISM Postdoctoral Training

The Department of Biochemistry at Wake Forest University Medical Center is in the Toxicology and Carcinogenesisprocess of strengthening its research programs in the areas of protein engineeringand molecular genetics. State-of-the-art facilities for automated protein sequence Positions available for study in various aspects of canceranalysis and peptide and oligonucleotide syntheses are already available through therecently established institutional Program in Molecular Genetics. In addition, research and toxicology through the Departments ofdepartmental faculty have access to the GCG sequence analysis software and databaseupdates through a VAX-based network A new Evans & Sutherland ESV moecular Biochemistry, Chemistry, Medicine, Pharmacology, andgraphics worktation will be delivered in the sunmer of 1990. Plans have beenfinalized to include laboratories for both high-resolution nmr studies and X-ray Pathology. Areas of ivestigation iclude syntheticciystallographic analyses of protein and nucleic acid structures in a new 240,000 chemistry related to toxic chemicals, mechanistic bio-square foot research building scheduled for completion in 1993. organic chemistry, chemistry of heavy metal antidotes,The Department of Biochemistry presently has openings at both faculty andpostdoctoral levels for research in enzyme structure and mechanism, as described DNA-carciogen physical interactions, enzymology ofbelow: animal and human cytochromes P-450 and chromatin1) AssistanVAssociate Professor- applicants at the Asistant Professor level proteins, the basis of metal carcinogenesis, chromatinshould have 2 years' postdoctoral experience in enzyme structural or mechanistic function, hepatocarcinogenesis, eicosanoids, regulationwork, focusing on applications of modem mutagenesis approaches. Applicants at theAssociate Professor rnk should also have a strong independent research programn in of glutathione metabolism, and NMR and mass spectro-place with a solid track record of extramurl funding. metry. Salaries are negotiable.2) Assistant Professor- applicants should have at least 2 years' postdoctoralexperience including research on the mechanisms of coenzyme-requiring enzymes Facultyand expression of doned genes for these studies. Ian A. Blair Thomas M. Harris3) Postdoctoral fellows - expertise ranging from prokaryotic molecular biology to Robert C. Briggs Mark M. Jonesexpression and mutagenesis of cloned genes, protein structure-function studies. Raymond F. Burk R. Stephen LloydSalaries are competitive and negotiable, depending on rank and experience. Send CV Peter Gettins Lawrence J. Marnettand list of publications and arrange to have three letters of reference sent to: F. Peter Guengerich

Dr. Moseley Waite, Chairman Applicants should submit curriculum vitae and threeDepartment of BlochemistryWake Forest University Medical Center letters of recommendation to Dr. F. P. Guengerich,300 South Hawthonme Road Director, Center in Molecular Toxicology, VanderbiltWinston-Salem, NC 27103Phone: (919) 7484373 University, School of Medicine, Nashville, TN 37232.

An Affirmative ActionlEqual Opportunity Employere-mail: ALC@MRIPS.BGSM.WFU.EDU

An Equal Opportunity/Afflnnative Action Employer

POSITIONS OPEN

COASTAL MARINE SCHOLAR POSTDOC-TORAL PROGRAM. Program aims to promote excel-lence in research in any aspect of marine science, coastalzone management, or related discipline. Twenty-onemonths of stipend will be provided ($27,300 for 12months). Scholars encouraged to pursue own researchinterests and to contact faculty sponsors regarding sup-plementary support. Preference will be given to canli-dates whose interests overlap those of faculty. Appoint-ment available 1 January 1991. All requirements forPh.D. must be completed at time of appointment. Ap-plications encouraged from students near completionand recent graduates with interest in any marine science-related discipline. Candidates should send a completeresume, detailed statement ofresearch interests, andhavethree letters of recommendation sent directly to: Dr.Roger Flood, Coastal Marine Scholar ProgramMS&C, State University ofNew York (SUNY) StonyBrook, Stony Brook, NY 11794-5000. Closing date:31 July 1990. SUNY Stony Brook is an AfilmtiveActonlEqual Opportunity Educator and Employer. AK 101.

AIDS RESEARCHPOSTDOCTORAL FELLOW/RESEARCH IN-

VESTIGATOR to study transepithelial transmission ofHIV using a cell culture system. Recent M.D. or Ph.D.degree (or equivalent) required. Send curriculum vitaeand the names and addresses of three references to:David M. Phillips, The Population Council, 1230York Avenue, New York, NY 10021.

POSTDOCTORAL ASSOCIATE. Study the mo-lecular and biochemical mechanisms of normal and neo-plastic cellular differentiation. Research is concernedwith mechanisms by which certain drugs induce leukemiccells to mature to adult forms devoid of cancerouspotential. Introduce certain genes into malignant cells toidentify the pathways that control the maturation pro-gram of cancer cells. Requires completion of all require-ments for Ph.D. in biochemistry or molecular biology.No specific experience required. Requires strong back-ground in cell culture, cloning sequencing, gene regula-tion, protein purification and expression, and immuno-assay techniques as evidenced by specific researchtraining or authored publications for scientific journals inthese disciplines. Monday to Friday, 9:00 a.m. to 5:00p.m.; $18,500 per year. Please send resume to: JobService Technical Unit, Connecticut Department ofLabor, 200 Foily Brook Boulevard, Wethersfield, CT06109. Refer to: Job Order #3072666. No callsaccepted.

POSTDOCTORAL RESEARCH POSITION.Available to study the biochemistry and cell biology ofthe actin cytoskeleton and/or endocytosis in the amocbaDictyostelium discoideum. Please send your credentials andthe names of the scientists who best know your work to:Theodore L. Steck, M.D., Department of Biochemis-try and Molecular Biology, University of Chicago,920 East 58th Street, Chicago, IL 60637. The Univer-sity of Chicago is an Afirmative Action/Equal OpportunityEmployer.

POSTDOCTORAL/RESEARCH ASSOCIATEMOLECULAR BASIS OF CANCER

Positions available to: (i) study the molecular basis oftumor suppressor gene action; (ii) identify and donenovel genes which modulate expression ofthe tumor cellphenotype; and (iii) study the biochemical, immunolog-ical, and molecular events mediating or associated withthe induction of terminal differentiation in human tu-mors. Expertise in current molecular biological tech-niques, such as cDNA doning, library screening, andPCR required. To a:pply, send curriculum vitae, state-ment of research goals, and three letters of reference to:Dr. P. B. Fisher, Columbia University, College ofPhysicians and Surgeons, 650 West 168th Street,New York, NY 10032. FAX: 212-305-5498. EqualOpportunity Employer.

RESEARCH SCIENTIST with Ph.D. in immunol-ogy and strong background in microbiology to head upprogram in Pediatric Otolaryngology ImmunobiologicResearch at Children's Hospital of Buffalo. Experiencerequired at postdoctoral level. Salary competitive. Sendcurriculum vitae to: Linda Brodsky, Department ofOtolaryngology, Children's Hospital of Buffilo, 219Bryant Street, Buffalo, NY 14222.

I684

POSIDOCTORAL OR RESEARCH ASSOCI-ATE in biochemistry, cell, or molecular biology to studythe regulation of synthesis and secretion ofmucin glyco-proteins. Studies will involve characterization of pro-teins, oligosaccharide chains, and glycosyltransferasesand metabolic studies with isolated mucus-secreting cells.Recombinant DNA techniques will be utilized to exam-ine the regulation of expression and genes encodingmucin glycoproteins and glycosyltransferases.

Please send curriculum vitae to: Dr. Joseph Mcndi-cino, Department of Biochemistry, University ofGeorgia, Athens, GA 30602.

POSTDOCTORAL RESEARCH ASSOCIATEThe U.S. Department of Agriculture (USDA), Agri-

cultural Research Service (ARS), Corn and SoybeanResearch Unit, Wooster, Ohio, is seeking a RE-SEARCH GENETICIST/MOLECULAR BIOLO-GIST, GS-11/12, to study the genetic, biological, andmolecular basis of resistance to maize dwarfmosaic virusin maize (see Mol. Pl.-Mcobe Inter. 2, 309-314). Ph.D.with knowledge of molecular biology and genetics re-qired; experence with PFGE and doning in yeastdesirable. Ph.D. must have been received within past 3years. Salary commensurate with experience. CS-11starting salary is $29,891; GS-12 starting slary is$35,825. Temporary, full-time, 2-year appointment, eli-gible to enroll in benefits. For further information,contact: Dr. Michael McMullen, USDA-ARS, De-partment of Agronomy, OARDC, Wooster, OH44691. Telephone: 216-263-3894. Apnlications re-ceived in response to this ad must be marked ON031.ARS is an Equal Opportunity Employer. Women and minori-ties are encouraged to apply.

POSTGRADUATE RESEARCH, ENVIRON-MENTAL PROTECTION AGENCY (EPA). Posi-tions available in environmental or chemical engineeringat Risk Reduction Engineering Laboratory in Cincin-nati, Ohio, and Edison, New Jersey. Experience inmunicipal wastewater system management or stormwaterrunoff characterization preferred. Contact: EPA, Post-gradluate Research Program, Science/E Ed-ucation Division, Oak Ridge AssocatU itiesP.O. Box 117, Oak Ridge, TN 37831-0117. Tele-phone: 615-576-3456.

RESEARCH ASSOCIATE. Position for a molecu-lar biologist to study gene regulation ofearly mammalianheart development utilizing gene knokout approacheswith retroviruses and modified antisense oligonudeo-tides in whole embryo culture, $30,000+ per annum.Send resume and three letters of reference to: Dr.Michael Solursh, Department of Biology, UniversityofIowa, Iowa Cit, IA 52242. The University ofIowa isan Equal Opportnity/nfinnatveAction Employer.

RESEARCH ASSOCIATEMOLECULAR BIOLOGY/VIROLOGY

Two positions immediately available to join an activeresearch group in gene regulation in human immuno-cytes and its relationship to retroviral infection. Famil-iarity with molecular biology and its application, and aPh.D. or equivalent is required. Two-year initial appoint-ment, with potential for advancement. Send resume to:Jewrey Laurence, M.D., or Susan Astrin, Ph.D., Cor-nell University Medical College, 411 East 69 Street,Newv York, NY 10021.

ASSISTANT/ASSOCIATERESEARCH BIOCHEMIST

METABOLIC RESEARCH UNITThe Metabolic Research Unit has a position availablk

starting 1 July 1990 for a Ph.D. or M.D. molecularbiologist with an established research interest and pro-gram on the mechanism of action of the estrogen recep-tor. Expenrence in genetic analysis of receptor action andoverexpression of steroid receptors for stuctural studiesrequired. Ability to obtain extramural funding is neces-sary for this position. Appointment and salary will becommensurate with the candidate's qualifications.Send a one-page summary ofresearch plan, curriculum

vitae, and three letters of recommendation to: Dr. JohnBaxter, Chairman, Search Committee, Metabolic Re-search Unit, 671-HSE, University of California, SanFrancisco, CA 94143-0516. T7he University of Caltfor-nia, San Francisco, is an Equal Opportunity/AfitnmativeActionEmployer. Women and minorities are encouraged to apply.

RESEARCH ASSOCIATE. To study the interac-tion of interleukins and of the hypothalmic-pituitary-adrenal-axis on intermediary metabolism. Experience msmall animal surgery, RLA, ELISA, and HPLC. Knowl-edge of tissue culture helpful. Joint appointment atShriners Burns Institute, Massachusetts General Hospi-tal, and Harvard Medical School. Send r6sumi to: LynneL. Levitsky, M.D., 51 Blossom Street, Boston, MA02114. Equal Opportunity Employer.

RESEARCH ASSOCIATE, BIOCHEMISTRY.Research involves the identification and characterizationofthe cell-specific xenobiotic binding proteins, their rolein the activation of drug-induced gene expression, andpleiotropic response. Clone the promoter regions ofxenobiotic responsive genes and use these for the devel-opment of transgenic animals. This is done, e.g., byextracting protein from rat liver, purify it by affinitychromatography, characterize it by polyacrylamide gelelectrophoresis. Inject protein into rahbsts to raise anti-bodies. Check results by immunoblottin". Isolate ge-nomic clones; sequence the DNA by di-deoxy chaintermination. Determine functions of the protein. Tabu-late, analyze, and publish results. Requires Ph.D. degreein biochemistry. Also requires 3 years ofexperience in thejob to be performed or 3 years of experience as apostdoctoral fellow or research assistant, biochemistry.In lieu of actual Ph.D. degree, may have finished allrequirements: experience required must be in biochemi-cal research, can be during Ph.D. program, and mustinclude: purification of proteins, affinity chromatogra-phy isolation and sequen of DNA. Must havepublished eight scholarly articles in scientific journals.Hours: 9:00 a.m. to 5:00 p.m., 40 hours per week, at$28,062 per year salary. Please send resume to: IllinoisDepartment of Employment Security, 401 SouthState Street-3 South, Chicago, IL 60605, Attention:L. Donegan, Refrence #1468-D.An employer-paid ad.

RESEARCH SCIENTIST. Ph.D. with 4 years ofexpenence in the area of enzymology and protein puri-fication. Fractionation of enzymes with various columnchromatographic techniques and resins, including affinitypurification schemes and applications of gel electropho-resis and of centrifugation methods. Use of radioactivematerials for the analysis of products of enzymatic reac-tions. Affinity labeling and active site titrations, enzymekinetics, and determination of kinetic parameters. Use ofoptical methods to assay biochemical reactions. Familiar-ity with methods of molecular biology for protein engi-neering. Experience with nudeic acid substrates andpreferably transfer RNAs. Salary range: $25,000 to$30,000. Please submit resume to: Mr. KennethHewitt, Room E19-230, Personnel Office, Massachu-setts Institute of Technology (M.I.T.), CambridgeMA 02139. M.LT. is an Equal Opportunity/AffinnasiveAction Employer.

RESEARCH SCIENTISTPHYSIOLOGY/TOXICOLOGY

A position is available in the Department of Physiol-ogy and Pharmacology for an assistant research scientist.This is a nontenure-track faculty position carryng all thetights and privileges of an assistant professor appoint-ment with the exception of tenure. Applicants shouldhave general interest in toxicology of the endocrinesystem and ideally the interaction of heavy metals withthe pituitary. While the position is intended to befull-time research, teaching opportunities at undergrad-uate, graduate, and professional levels may be arranged.Salary dependent upon qualifications. Please submit cur-rent curriculum vitae, statement of research interests, andnames, addresses, and telephone numbers of four refer-ences to: Dr. C. Michael Moriarty, Office of the ViCePresident for Research, 616 Boyd Graduate StudiesReearch Center, The University of Georgia, Athens,GA 30602. The University ofGeorgia is an Equal Opportu-nitylAffirmative Aaton Institution.

SCIENCE, VOL. 248

CIENCEcan publish YOUR LOGO with your one-

column line classified ad. No extra fee is assessed:you will be billed at our regular line rate for thenumber of lines the logo occupies. For details,call Classified Advertising: 202-326-6555.I

POSITIONS OPEN POSITIONS OPEN

df

STAFF SCIENTISTS &

POSTDOCTORAL

FELLOWS

Regeneron Pha... D [.ated todeveloping therapeutic agen'tsg"" r"d"eg"enerative and traumaticneurological diseases, is seeking to apply recent advances inthe understanding of neuronal growth and regeneration.

Regeneron offers an exciting, collegial environment in whichstate-of-the-art molecular skills are brought to bear onoutstanding problems in neurobiology and medicine. Keyprojects focus on the discovery, purification and molecularcloning of novel neurotrophic growth factors, and on theassessment of their biological roles as well as therapeuticpotentials using innovative cell culture methods and animalmodels.

Positions in Neurobiology require expertise in the areas of:

* Neural Regeneration (PNS/CNS)* Models of Neuronal Disease

All positions in Neurobiology require a strong neuronatomicalbackground. Experience with receptor autoradiographyand/or in situ hybridization is desirable.

Additional openings in Molecular and Cell Biology requireskills in the areas of'

* Protein Biochemistry* Manunalian Expression Vectors* Molecular Genetics* Monoclonal Antibodies

Regeneron's modern facility is located on a 275-acre woodedcampus in Westchester County, 20 miles north of Manhattan,near major universities and medical centers. We offerexcellent compensation packages, including generous stockoptions. Suburban Westchester features attractive andaffordable housing, outstanding public schools andrecreational facilities along with ready access to the culturaland business centers of New York City.

Please forward your resume, in confidence, to: Ms. CarolDeaken, Regeneron Pharmaceuticals, Inc. 777 Old Saw MillRiver Road, Tarrytown, NY 10591-6706. Equal opportunityemployer.

REGENERONPharmaceuticals, Inc.

Applied bioTechnology is a growing companyspecializing in* genetically engineered vaccines for the humanand veterinary markets* novel products for cancer therapeutics anddiagnosticsSeveral excellent opportunities exist for highlymotivated individuals who have a BS or MS in theBiological Sciences and relevant laboratory experience.Positions involve preparation of DNA and RNA,construction and isolation of recombinant plasmids,restriction mapping, nucleic acid hybridization,in vitro mutagenesis, and DNA sequence analysis.Challenging work environment with competitivesalary and excellent benefits.Please submit your resume to:Applied bioTechnology, Inc.80 Rogers Street, Cambridge, MA 02142An eid cr&prl w0boyermfl

AppliedbioTechnology, Inc-

ASSOCIATESCIENTISTMOLECULAR BIOLOGYThe Bristol-Myers Squibb Company Industrial Division. aleader in biotechnology and a major internationalmanufacturer of pharmaceutical products, has an excellentresearch opportunity in its Biological Process DevelopmentGroup in Syracuse. New York. The Biological ProcessDevelopment Group is rapidly expanding with a new proteinrecovery and purification facility currently under construction.The successful candidate will be responsible for thedevelopment of microbial strains that produce increased titersof current antibiotics through molecular manipulation orenzymes for biotherapeutics and bioconversions.Qualifications include a BS or MS in Molecular Biology orrelated discipline and a strong background in gene cloning.Additional experience in molecular biology of fungalmicroorganisms is desirable.Bristol-Myers Squibb offers an excellent salary andcomprehensive benefits. For prompt. confidentialconsideration, forward your resume with salary history andrequirement to: MANAGER OF EMPLOYMENT

/tt BRISTOL-MYERS SQUIBB COMPANYINDUSTRIAL DIVISION

w 0\ P.O. Box 4755, Syracuse. New York 13221-4755An equal opportunity employer MF;'H,V

11VII

I

SITUATIONS WANTED

RESEARCH DIRECTORUBIQUITN BIOTECHNOLOGY

Proteonix, a biotechnology company involved in thedevelopment and commercialization of a proprietaryubiquitin-fusion technology, is seeking a research direc-tor. thisperson will be responsible for formulating andimplementing research programs to develop applicationsof ubiquitin-protein fusions and ubiquitin-dependentproteolysis in the production of research and pharmaceu-tical products. We are looking for a highly motivated,accomplished molecular biologist/biochemist who canprovide creative leadership to an initially small team ofresearchers, with the potential to expand into a largeresearch group. Applicants must hold a Ph.D. in molec-ular biology/biochemistry, with at least 2 years of rele-vant postdoctoral experience. Detailed knowledge ofandfirsthand research experience with the ubiquitin systemare highly desirable. As this is primarily a researchposition, business experience is an advantage, but not anecessity. This position will be available starting in early1991, in our Cambridge, Massachusetts, laboratories.

Proteonix offers a competitive salary, benefits, andstock option program.

Applications, comprising curriculum vitae and thenames of three references, should be sent to the followingaddress by 15 July 1990:

Richard J. MasseyProteonix Inc.

1530 East Jefferson StreetRockville, MD 20852

Proteonix is an Equal Opportunity Employer.

^ Agricultural RESEARCHResearch IMMUNOLOGISTService

A senior research position in immunology (permanentfull time, GS-12/13/14/15) is available at the U.S. De-partment of Agriculture (USDA)-ARS Regional Poul-tryResearch Laboratory, East Lansing, Michigan. Thelaboratory conducts a basic mission-oriented, multidis-ciplinary program focused on oncogenic viruses, recom-binant DNA vaccines, and host genes that determinedisease resistance in poultry. Goal of the position is tooptimize host cellular immune responses to immunogensin chickens. Salary commensurate with experience(range: $35,825 to $59,216). Experience in cellularimmunology and U.S. citizenship required. Ph.D. or equiv-alent desirable. Send curriculum vitae with three refer-ences to: Dr. R. L. Witter, USDA-ARS RegionalPoultry Research Laboratory, 3606 East Mt. HopeRoad, East Lansing, MI 48823 by 15 July 1990.Applications must be marked ON038. An Equal Oppor-tunity Employer.

NUCLEIC ACID/PROTEIN INTERACTIONSThis major Canadian biopharmaceuticals company of-

fers outstanding opportunities for innovative and practi-cal scientists of proven accomplishment. Positions areavailable for RESEARCH SCIENTISTS with severalyears of research experience, desirably industrial, as wellas for POSTDOCTORAL FELLOWS:

* MOLECULAR BIOLOGISTS with experience inengineering proteins.

* NUCLEIC ACID CHEMISTS for the synthesis ofmodified oligonucleotides.

Allelix Biopharmaceuticals, located near Toronto, isfinanced by several leading Canadian concerns. Thecompany offers a competitive compensation package.

For consideration, please forward r&sum6s with threereferences, quoting file #AB9004, to:

Mr. Walter GagenAllelix Biopharmaceuticals

6850 Goreway DriveMississauga, Ontario L4V lPl, Canada

CELL BIOLOGIST. The Department of Surgery atStanford invites applicants for full-time RESEARCHPOSITION (Ph.D. required), to supervise fellows andconduct research in cytokine/hormone interactions andmechanisms of actions in hepatocyte cultures. Sendresume: Fletcher Starnes, Stanford University Medi-cal Center, Room S067, Stanford, CA 94305-5101.Telephone: 415-723-5672. AfinmativeAcion/Equal Op-portunity Employer.

FISHERY RESEARCH. The Texas Parks and Wild-life Department seeks a research specialist to design,perform, and report applied quantitative research intobroad aspects offishery management; manage data bases;and support technical programs. Qualifications includean M.S. degree in fishery science, biology, statistics, orrelated field. Contact: Steve Gutreuter, Ph.D., TexasParks and Wildlife Department, 4200 Smith SchoolRoad, Austin, TX 78744. Equal Opportunity/AfimnativeAation Employer.

SURGICAL RESEARCHER. The Department ofSurgery and the Research Institute at The Mary ImogeneBassett Hospital, a major teaching affiliate of ColumbiaUniversity, are seeking a Ph.D. to conduct basic surgicalresearch in an area ofgeneral surgery. Laboratory spaceand iitial support provided. Competitive salary, with afine benefits package and academic appointment. Locatedin Cooperstown, New York, a rural four-season resortvillage with excellent schools and unusual recreationaland cultural opportunities. Reply: Michael S. Gold,M.D., Surgeon-in-Chief; The Mary Imogene BassettHospital, Cooperstown, NY 13326. Telephone: 607-547-3968 or Thomas A. Pearson, M.D., Ph.D., Di-rector, Research Institute, The Mary Imogene BassettHospital, Cooperstown, NY 13326. Telephone:607-547-3045.

RESEARCH FELLOW A. Medical facility in north-eastern Ohio. Studies the structural similarities and dif-ferences between the two forms of angiotensin-con-verting enzyme (ACE). Isolates the gene(s) encoding theisozymic forms ofACE to determine if they are productsof one gene or two genes. Clones and characterizesmyotropin, and studies its role in hypertrophy of theheart. Uses the techniques of constructing and screeningcDNA libraries, screening genomic libraries, Northernand Southern blotting, DNA sequencing, in vitro tran-scription, in vitro translation, primer extension analysis,S1 nuclease mapping, CAT assays, and polymerase chainreactions. Must possess knowledge of hormone-inducedgene regulation as evidenced by either work experience,published materials, or academic projects. RequiresPh.D. in biology. No experience required. Forty hoursper week, 8:00 a.m. to 5:00 p.m.; $23,000 per year. Musthave proofoflegal authority to work permanendy in the UnitedStates. Send resume in duplicate (no calls) to: J. Davies,JO# 1084568, Ohio Bureau of Employment Serv-ices, P.O. Box 1618, Columbus, OH 43216.

ANNOUNCEMENTS

HELP! Scientists in all fields interested in writingserious evaluative book reviews of current trade booksfor children and young adults in their fields are needed byAppraisal: Science Books For Young People, a quarterlynonprofit book review journal based at Boston Univer-sity. Your payment will be the books you review. Reviewas many or few as you wish, for any age group you prefer.No specialty is too obscure. Write to: litor of Ap-praisl, Boston University School of Education, 605Commonwealth Avenue, Boston, MA 02215.

NATIONAL TRANSGENICDEVELOPMENT FACILITY

OPERATED BY DNX, INCORPORATEDUnder contract with National Institute of Child

Health and Human Development (NICHD) we willmicroinject your DNA construct and provide transgenicmice.

Production costs will be subsidized by NICHD. Forfurther information contact:

DNX Transgenic ServicesAttention: Dr. Carl A. Pinkert

303B College Road EastPrinceton, NJ 08540

Telephone: 609-520-0300, ext. 99

i686

BIOCHEMIST, Ph.D. Protein, enzymes, monoclo-nal polyclonal antibody, affinity chromatography recep-tor purification, RIA, ELISA, hemopoietic growth fac-tors. R&D position. Waheed, 4724 Denbigh Court,AlLison Park, PA 15101.

BIOCHEMIST/MOLECULAR BIOLOGIST,Ph.D. (1986). Must relocate to Syracuse/Utica/Norwich,New York, area. Experienced in protein purification,plant genetic engineering. Box 52, SCIENCE.

BIOLOGICAL OCEANOGRAPHER, M.S., with14 years of experience. Zooplankton research, environ-mental consulting, teaching, administration. Seeks per-manent academic/aquarium/private industry position.Box 60, SCIENCE.

BIOLOGIST, D.Phil. MBA (expected). Biasedtoward free-market environmentalism, against excessivelegislation. Seeks policy/management/research position,industry or non-profit. Box 53, SCIENCE.

CELLULAR IMMUNOLOGIST, Ph.D. Experi-ence: cytokines, marrow transplantation, adoptive cellu-lar immunotherapy. Seeks cha-engig position in hospi-tal, academia, or large company. Box 54, SCIENCE.

ELECTRON MICROSCOPIST, Ph.D. Integratedimaging and analysis of biological materials, projectresearch, system development, and facility management.Industrial/academic position. Box 61, SCIENCE.

MOLECULAR BIOLOGIST, Ph.D.; 3 years ofpostdoctoral: in situ hybridization, cDNA cloning, blots(S/N/W), tissue culture, fungal genetics. Industry, gov-ernment, academia. Box 55, SCIENCE.

MOLECULAR BIOLOGIST/VIROLOGIST.Ph.D. biochemistry (1981). Experience in gene expres-sion, recombinant DNA, PCR, immunochemistry. Seeksresearch/industry position. Box 56, SCIENCE.

NEUROETHOLOGIST. Active research, inverte-brate visual perception. Experience: 10 years of businessmanagement, 2 years of laboratory management, exten-sive teaching. Seeking academic position. Box 57,SCIENCE.

NEUROSCIENTIST. Broad biological background.Skills in electrophysiology, computer programming, ran-dom and deterministic models. Likes to teach. Washing-ton, D.C., area preferred. Box 58, SCIENCE.

Ph.D. BIOCHEMISTRY (1978). Teaching/researchexperience in enzymology, protein purification, molecu-lar biology, immunology, HIV. Seeks industrial or re-search position anywhere. Box 59, SCIENCE.

SCIENCE WRITER. Commercially published au-thor/teacher, Ph.D. neuroscience, seeks academic, indus-trial, or government writing/editing position. WestCoast preferred. Dean R. Lambe, P.O. Box 14, Water-town, OH 45787. Telephone: 614-749-3476.

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Research Genetics

SCIENCE, VOL. 248

More than150,000 peoplepaicoto see your ad

in

SCIENCEClassified Advertising Department

Telephone: 202-326-6555FAX: 202-682-0816

POSITIONS OPEN POSITIONS OPEN

Faculty Positionsin Molecular Physiologyand BiophysicsHS-F-0024-90-05-S

The Department of Physiology andBiophysics invites applications for twotenure track positions, preferably atthe level of assistant professor butoutstanding applications for associateand full professor positions will alsobe considered. Candidates mustpossess a Ph.D. in either Physiology,Biophysics, Molecular Biology,Biochemistry or in a related field.Candidates with strong credentials inmembrane protein structure andfunction and/or the molecularmechanism of hormone action whoemploy electrophysiological,biophysical, and molecular biologyapproaches are especiallyencouraged to apply; however,excellent candidates in all areas ofcellular and molecular physiologyand biophysics will be given seriousconsideration. Terms are highlycompetitive and the positions willprovide an excellent opportunity todevelop a strong, independentresearch program in facilities whichare state-of-the-art in an expandingdepartment and research community.Submit curriculum vitae, briefstatement of present and proposedresearch interests, representativereprints, and names of fourreferences to:

Dr. Simon J. Pilkis, M.D., Ph.D.Department of Physiologyand Biophysics

Basic Science Tower, T-6, Room 140Health Sciences CenterState University of New YorkStony Brook, NY 11794-8661

SUNY Stony Brook is an affirmativeaction/equal opportunity educator andemployer.

StonyBrook I

We're givingscientific professionalsthe opportunit todiscover their potential.

Ethicon, Inc. is a Johnson & Johnson Company anda world leader in the manufacture of surgical closuredevices. Determined to build on our success, we'reinvestigating a wide range of opportunities in woundclosure and wound healing technologies that will offeryou personal and professional challenges. The follow-ing opportunities are currently available:

SECTION MANAGER!PRINCIPLE SCIENTISTSurgical PhannacologyYou will oversee development activities related to dos-age forms for parenteral and topical applications. Thisincludes preclinical formulations; initiation, monitoringand documentation of formulation stability studies;and process development, scale-up and documenta-tion, according to GLP and GMP regulations. You'llalso participate on project development teams and actas liaison between our research and clinical manufac-turing areas.A Ph.D. or equivalent in Pharmacy, PharmaceuticalScience or a related discipline, and 3-5 years of indus-trial experience in pharmaceutical development, arerequired. Experience in formulations development, sta-bility studies design and analysis, process develop-ment and scale-up, and preclinical formulations ishighly desirable; knowledge of protein drug and paren-teral formulations, and topical dosage forms is a plus.Supervisory experience is preferred.

SCIENTISTAnalytical ChemistryYou will be responsible for analytical methods devel-opment, troubleshooting and problem-solving in sup-port of product and process development or poly-meric and drug substances utilizing a variety oftechniques, including HPLC, GC, Ion Chromatography,AA, WIVIS, pH, and Titrimetry. To qualify, we requirea Ph.D. in Analytical or Physical Chemistry or equiva-lent, and 0-5 years of post doctoral experience ingeneral analytical and instrumental analysis. Industrialanalytical chemistry laboratory experience is desirable.

Conveniently located within an hour's drive of Phila-delphia and New York, we offer a challenging work en-vironment, competitive salary and the comprehensiveJohnson & Johnson Company benefits package, in-cluding on-premises total health and wellness facilityand complete medical and dental plans. Please sendyour resume, indicating position of interest, in confi-dence to: Employment Manager, Ethicon, Inc., P.O.Box 151, Somerville, NJ 08876-0151. We are an equalopportunity employer.

ETH I CO N1a company

AIDS Books from AAAS

AIDS 1988: AAAS Symposia PapersEdited by Ruth Kulstad

Foreword by C. Everett Koop

This volume contains many of the ground-breaking papers on AIDS presented at the1988 AAAS Annual Meeting.

The wide variety ofthe papers presentedhere reflects the current thinking aboutAIDS research today-that control overthe AIDS epidemic must be achievedthrough a collaborative, multi-disciplinaryeffort that includes not only the medicaland biological sciences, but the social andbehavioral sciences as well.

This fully indexed volume is organizedinto five major sections: The first explores.he epidemiology and natural history ofAIDS and the HIV infection both in theUnited States and internationally. It alsolooks at the difficulty of predicting thecourse of the virus-statistical issues;

patterns of HIV-1 incubation, infectious-ness, and transmission; and approaches todemographic impact modeling.

Section two discusses the social conse-quences of AIDS as they relate to gender,intravenous drug users, and public policy,and it examines the dilemmas that AIDSpresents to the medical community.The third section focuses on the AIDS

prevention strategies currently employedaround the world.

Section four considers the economic,political, ethical and legal issues surround-ing the epidemic.

The final section presents several recentmedical and biological studies on AIDSand HIV.

AIDS 1988 is a timely, authoritativesource ofinformation on the growing bodyofAIDS research being conducted aroundthe world. It is essential for medical,biological, social, and behavioral scien-tists, and for everyone who is profession-ally or personally concerned about theAIDS epidemic.

1988; 478 pp.; softcoverindex; 12 appendices#88-19S - $29.95 (members $23.95)

AIDS: Papers from Science,1982-1985

Edited by Ruth Kulstad

This collection includes frequently citedresearch papers and news reports on AIDSthat were published in Science betweenAugust 1982 and September 1985.

Many of the papers relate directly toAIDS research, while others touch onrelevant aspects of the immune system.The news stories help to explain the ongo-ing research, while focusing on some ofthe sociological questions raised by thedisease. The book is arranged chronologi-cally, enabling the reader to trace the his-

tory of the AIDS epidemic through Sep-tember 1985-a history that is of greatsociological interest.

This fully indexed collection is valuablenot only for the experimental data andconclusions, but also as an excellent bib-liographic reference of AIDS work in majorjournals worldwide.

1986; 654 pp.; softcoverdetailed indexes and illustrations#85-23S - $19.95 (members $15.95)

American Association for the Advancement of Science