Ks Topikal
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Transcript of Ks Topikal
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3120
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KortikosteroidAnti inflamasi / Anti Alergi
Imunosupresif
Anti proliferatif / Anti mitotik
Vasokonstriksi
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Obat topikalAbsorbsi perkutan
kulit - sawar
Epidermis Stratum corneum
Stratum granulosumStratum spinosum
Stratum basalis
Lipofilik
HidrofilikDermis
Jar. Lemaksubkutan
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Obat topikalZat aktif
Vehikulum
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Vehikulum
- Melarutkan- Membawa- Menahan- Melepaskan
Melembabkan kulit Meningkatkan permeabilitas kulit Meningkatkan penetrasi
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Kortikosteroidtopikal
Transepidermal Interseluler Transeluler
Transappendageal
Transekrinal Transfolikuler
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DepoStratum corneum
Stratum granulosumStratum spinosum
Stratum basalisMetabolismeReseptor
SistemikDepo
Difusi
Kapiler
DermisLemak subkutis
KS
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Fosfolipase A2
Mediatorinflamasi
• Tromboksan• Prostaglandin• Lekotrien
Kortikosteroid
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DNA
Absorbsi
Lipokortin
KS
Binding
Translocation
Transkripsi RNA
Phospholipase A2 —
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Sawar / Integritas kulit
Absorbsi perkutan KS
Kerusakankeradanganpenebalan
Suhu / kelembaban Oklusif Vehikulum
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Vehikulum
Kelarutan KS Pelepasan KS Kestabilan Efek hidrasi humectan
• Propilen glikol• Gliserol• Polietilen glikol
Optimizing vehicle
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Pedoman Penggunaan KS
1. Pemilihan KS2. Indikasi3. Kondisi kulit4. Lokasi tubuh5. Usia6. Bentuk sediaan7. Cara memakai
Efek samping
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POTENSI KS• Golongan I : sangat kuat Klobetasol propionat krim 0,05% Betametason dipropionat 0,05%
• Klobetasol propionat ointment 0,05%
• Golongan II : poten Mometason furoat ointment 0,1% • Desoksimetason krim 0,25%• Golongan III : poten Flutikason propionat ointment 0,005% • Triamsinolon asetonid ointment 0,1%• Golongan IV : intermediate Flusinolon asetonid ointment 0,025% Hidrocortison 17-valerat ointment 0,2%
• Mometason furoat 0,1% krim/lotion
• Golongan V : intermediate Flutikason propionat krim 0,05% Flusinolon asetonid krim 0,025% Hidrocortison 17-valerat krim 0,2%
• Prednikarbat krim 0,1%• Hidrokortison butirat krim 0,1%
• Golongan VI : lemah Aklometason krim 0,05% Desonide krim 0,05%
• Triamnisolon asetonid krim 0,1%• Hidrokortison butirat solution 0,1%
• Golongan VII : sangat lemah Deksametason krim 0,1% • Hidrokortison krim 1,25%
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Efek samping KSEpidermis penipisan epidermis
hambatan melanosit
Dermis sintesis kolagen striae perdarahan kapiler -
purpura Vaskular Rebound
vasodilatasi edema
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Efek samping KS
LOKAL : - Atrofi- Infeksi- Rosasea- Dermatitis perioral- Hipertrikhosis- DKA
SISTEMIK
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