Telephone: (201) 267-8670www.modularprocess.com

KOCH MODULAR

PROCESS SYSTEMS

Designing Separation Systems for Bio-Produced Chemicals

Prepared for: Pacific Rim Summit on Industrial

Biotechnology

Date: December 2014

45 E isenhow er Dr ive , Su i te 350 , Param us, NJ 07652 | Te l : (201 ) 267 -8670 | Fax : (201 ) 368 -8989 | w w w.m odularprocess .com

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WHO IS ?

Koch Modular Process Systems (KMPS) is a joint venture with Koch-

Glitsch LP, one of the world's most prominent suppliers of mass

transfer equipment. Koch-Glitsch's parent company is Koch Industries,

one of the largest privately held corporations in the United States.

For over 20 years KMPS has successfully designed and constructed

mass transfer systems for the worldwide Chemical Processing

Industry. Our customer’s rely upon KMPS for our quality products and

technical expertise.

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Telephone: (201) 267-8670www.modularprocess.com

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What We Do

Specialists in Process Design and Construction of Modular Mass Transfer Systems for Solvent Recovery, Wastewater Stripping, Product Purification, Organic Chemical Separations, Acid Gas Treating and Environmental Applications. KMPS also provides engineered components and engineering services, including equilibrium data development, process development and pilot plant testing.

Objective:

Provide economic solutions to separation problems.

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Telephone: (201) 267-8670www.modularprocess.com

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Who We Are

Chemical Engineers Other Engineers

Process Mechanical

Project Civil / Structural

Control & Automation Electrical

Business Development Instrumentation

Design Drafting Other Technical

Piping Design Pilot Plant Operations

Vessel Analytical Chemist

Structural Quality Control

Process / P&ID

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Telephone: (201) 267-8670www.modularprocess.com

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Areas of Expertise

Process Simulation Liquid-Liquid Extraction

Continuous Distillation Gas Absorption

Steam Stripping Reaction Kinetics

Batch Distillation Reactive Distillation

High Vacuum Distillation Process Chemistry

Azeotropic Distillation Thermal Design of Shell/Tube Exchangers

Extractive Distillation

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Telephone: (201) 267-8670www.modularprocess.com

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Process Applications

We service the Chemical, Electronics , Alternative Energy, Pharmaceutical, Petrochemical, Biotech, Food and Flavor & Fragrance with typical applications such as:

Purification of Silicon & Silanes Separations for Biomass

Fermentor Products &Cellulosic Ethanol Production

High Vacuum Separations of Citrus Oils and Flavor & Fragrance Products

Solvent Recovery Systems Aqueous Waste VOC Removal

Pharmaceutical Intermediates Multicomponent Separations Solvent Drying Pilot Plants/Semi-Works Purification of Organic/Inorganic Products Organic/Inorganic Chemical Manufacture Acid Gas (e.g., CO2 & H2S) Removal from

Syngas, Natural Gas, Flue Gas or LPG

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Telephone: (201) 267-8670www.modularprocess.com

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Products

Modular Mass Transfer Systems

Liquid-Liquid Extractors

KARR® Column, SCHEIBEL® Column

Engineered Equipment

Process Control Systems – DeltaV, PLC & DCS

Engineering Services:

Process Development & Process Simulations VLE Data Generation/Regression

Process Feasibility Studies Heat Exchanger Thermal Design

Engineering Packages Troubleshooting Existing Equipment

Pilot Plant Testing Startup Assistance and Operator Training

KARR® and SCHEIBEL® are registered trademarks of Koch-Glitsch, LP.

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M O D U L A R P R O C E S S S Y S T E M S | D I S T I L L A T I O N | L I Q U I D E X T R A C T I O N | E N G I N E E R I N G | P I L O T T E S T I N G

Telephone: (201) 267-8670www.modularprocess.com

Modular Mass Transfer

Systems

Extensive experience providing distillation systems designed to recover high purity chemicals. This particular project employed extractive distillation.

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Telephone: (201) 267-8670www.modularprocess.com

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Proven Separations Experience

Acetaldehyde Aniline Carbon TetraCl Esters

Acetic Anhydride Benzene Chloroform Ethanol

Acetic Acid Benzophenone Cyclohexane Ethyl Acetate

Acetone BHT Cresols Ethylbenzene

Acetonitrile Br Hydrocarbons Cumene Ethyl Dichloride

Acrylonitrile Butadiene DCPD Formaldehyde

Amines Butanol Dioxane Formic Acid

Ammonia Butyl Acetate DMAC Furfural

Amyl Acetate Caffeine DMF

Amyl Alcohol Carbon Dioxide DMSO

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Telephone: (201) 267-8670www.modularprocess.com

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Proven Separations Experience

Geraniol Isopropyl Ether Napthalenes Pyridines

Glycols Isopropyl Acetate n-methyl Pyrrolidone Refrigerants

H2S Isopropyl Alcohol Nitroethane Styrene

Hexane Limonene Nitromethane THF

HMDO Linalool Nitrophenol Thionyl Chloride

Heptane MEK Perfumes Toluene

Indene Methanol Phenol Trichloroethane

Ionones Methyl Acetate Phenylenediamine Trichloroethylene

IPA Methylene Chloride Piperidine Water

Isophorone MIBK Propanol Xylene & Xylenols

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Telephone: (201) 267-8670www.modularprocess.com

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KMPS and Bio-Technology

• Recently – large emphasis on production of chemicals from biomass (fermentation, algae)

• Many Bio-Technology companies need help developing optimal separation process for recovery and purification

• KMPS has the expertise, experience and pilot plant facility to optimize the design of the separation systems

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Telephone: (201) 267-8670www.modularprocess.com

Biofuel & Biochemical

Our liquid-liquid extraction and distillation technologies are critical resources for the product recovery and purification needs of this important and developing sector of the industry

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Telephone: (201) 267-8670www.modularprocess.com

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KMPS Pilot Plant (Houston, TX)

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KMPS maintains a pilot plant dedicated to distillation and extraction R & D and applications testing. We generate data for accurate scale-up.

M O D U L A R P R O C E S S S Y S T E M S | D I S T I L L A T I O N | L I Q U I D E X T R A C T I O N | E N G I N E E R I N G | P I L O T T E S T I N G

Telephone: (201) 267-8670www.modularprocess.com

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Full range of services:

Feasibility Studies

Process Design

VLE/LLE Data Development

Pilot Plant Testing

Process Expertise:

Distillation

Liquid-Liquid Extraction

Steam Stripping

Absorption

Successful Pilot Plant Testing =

Process Performance Guarantee

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Telephone: (201) 267-8670www.modularprocess.com

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Fermentation Process with LLE

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Fermentation

Additional Dist.Product(s) Purification

Distillation (Solvent Recovery)

Broth TreatmentFiltration

CentrifugeCell Disruption

Liquid-Liquid Extraction

Solvent Stripping

Recycle Solvent

Spent Broth Recycle

Solvent

Extract

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Telephone: (201) 267-8670www.modularprocess.com

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Recovery of Carboxylic Acids from

Fermentation Broth• Broth generated by fermenting

cellulosic materials – ~5% acids

• LLE Goal: >95% recovery (high purity) and minimal solvent use

• Ethyl acetate solvent – but emulsified easily

Preliminary Data in RDC Columns

• Difficult operation due to emulsification

• < 90% acid recovery

• High S/F ratio – 2.0

KARR® Column Required

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Telephone: (201) 267-8670www.modularprocess.com

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Recovery of Carboxylic Acids from Broths

Using a Low Boiling Solvent

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FermentationBroth

5 % carboxylicacids

Solvent:Ethyl Acetate

Extraction

Raffin

ate

Stripp

ing

Solve

nt

Re

cove

ry

Raffinate

RecycledEthylAcetate

Extract

Carboxylic Acids

Aqueous Raffinate

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Telephone: (201) 267-8670www.modularprocess.com

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Pilot KARR® Column for Carboxylic

Acids - 1” diameter x 12’ Plate Stack

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Hot Oil

Whole Broth Feed Ethyl Acetate

Aqueous Out

(Raffinate)

Organic Out (Extract Phase)

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Telephone: (201) 267-8670www.modularprocess.com

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Extraction Testing Results

• KARR® Column is correct design for this process which failed in RDC column

• S/F ratio improved to 1.5 (client expected 2)

• 96-97% recovery at room temperature and 98-99% recovery at 40-45 °C. Approximately 7 theoretical stages generated.

• Design capacity 26.5 m3/m2hr

• Complete system (LLE + distillations) designed, fabricated, and installed including KARR® Column installed on right

• LLE testing identified “unknown” component

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Telephone: (201) 267-8670www.modularprocess.com

Recovery of Carboxylic

Acids from Fermentation

Fabrication and installation of a complete modular system including LLE column, solvent recovery column and steam stripping column. Modules contain all equipment, exchangers, pumps, and tanks along with piping, instrumentation, and electrical wiring preinstalled.

M O D U L A R P R O C E S S S Y S T E M S | D I S T I L L A T I O N | L I Q U I D E X T R A C T I O N | E N G I N E E R I N G | P I L O T T E S T I N G

Telephone: (201) 267-8670www.modularprocess.com

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Summary - Options for LLE Testing

• KMPS Pilot Plant – Houston, Texas

• Purchase Pilot Column from KMPS

• Rent Pilot Column from KMPS – Column alone or complete set-up

KMPS personnel are available for set-up and testing at client facility

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M O D U L A R P R O C E S S S Y S T E M S | D I S T I L L A T I O N | L I Q U I D E X T R A C T I O N | E N G I N E E R I N G | P I L O T T E S T I N G

Telephone: (201) 267-8670www.modularprocess.com

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CONCLUSIONS

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KMPS expertise is in design and supply of separation systems

The pilot plant allows us to optimize processes using actual process liquid and provide process performance guarantees

Modular construction provides fully assembled units shipped directly to the job site.