Know your basic parts Supply the body with Oxygen Dispose of Carbon dioxide.
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Transcript of Know your basic parts Supply the body with Oxygen Dispose of Carbon dioxide.
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Know your basic parts
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Supply the body with Oxygen Dispose of Carbon dioxide
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Respiratory zone:◦ Actual site of gas
exchange◦ (some exchange -
Respiratory bronchioles, alveolar ducts) alveoli (major site)
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Conducting zone:◦ Conduits – purify,
humidify, and warm incoming air
◦ Include all other respiratory passageways
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Provide airway for respiration
Moisten & warm air Filter air (mucus & cilia)
(breath in thru nose & out thru mouth)
Site of olfactory (smell) receptors
Resonating chamber for sound waves (hold your nose closed & see how you sound!)
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Mucus traps the “junk” and the cilia sweeps it up toward your throat so you can swallow it or spit it out.
Smoking kills cilia so smoker’s constantly have to cough to clear the mucus out!
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The cilia in your nose become sluggish & slow when they are cold & do not move the mucus down into your throat
Mucus in the nasal cavity accumulates & dribbles out
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Nasal Conchae aka. NasalTurbinates= increase SA of mucosa exposed to air to help warm & filter it – also increase turbulence (mini tornado effect) of air – more inhaled particles swirled onto mucus and trapped
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Nasal cavity separated from oral cavity by the palate (roof of mouth)◦ Anterior – hard
palate◦ Posterior – soft
palate
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Lighten skull Act a resonance chamber Produce mucus
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Pharynx serves as common passageway for food (& fluids) and air.
Color code the 3 parts of the pharynx on the diagram in your notes
The names give you location clues!
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Nasopharynx – air only◦ During swallowing, Soft palate & uvula rise
upward to close off nasopharynx which prevents food & fluids from entering it
Oropharynx & Laryngopharynx – food, liquids & air◦ Food will be directed posteriorly to the
esophagus◦ Air will go anteriorly into the larynx
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Pharyngeal tonsils: aka. Adenoids – located in nasopharynx
Palatine tonsils: located in oropharynx Lingual tonsils: located at base of tongue All tonsils are lymph nodes & work with
immune system You will be labeling these on the back page
diagram
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Provides patent (open) airway
Act as a switching mechanism (between respiratory & digestive systems)
Voice production (location of vocal cords)
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Know this: Laryngeal prominence on the thyroid cartilage
Seen externally as Adam’s apple
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9th cartilage When air is flowing into the larynx – free
edge projects upward During swallowing:
◦ Larynx is pulled upward◦ Epiglottis is tipped back and down to cover
laryngeal inlet into trachea◦ Routes food/fluid into esophagus
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Initiated if anything other than air enters the larynx
Pressure from air moves object upward out of the larynx◦ Reflex does not work when unconscious so not a
good idea: To give fluids to an unconscious
person Also a reason why people in an
alcoholic coma often die from aspirating their own vomit.
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The ciliated mucosa (mucociliary escalator) continuously propels the mucus which contains dust particles and debris to the throat so it can be expelled or swallowed.
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Diminishes ciliary activity Coughing is ONLY method of preventing
mucus accumulation in the lungs Smokers should never be given medications
that INHIBIT the cough reflex.
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Trachea is reinforced internally by 16-20 C shaped rings (Be able to explain – see diagram on next slide also)
Outer portion of C – causes trachea to stay patent (open) and not collapse
Inner portion (open part) of C – allow trachea to be flexible and gives esophagus a place to expand into upon swallowing.
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Heimlich manuver is the same principle as a cough
Used to press air out of lungs in case someone cannot inhale to initiate a cough
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-ostomy = cut a hole into Used in cases of:
◦ Abnormalities◦ Cancers◦ Obstructions◦ Injuries to area◦ Etc.
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Trachea divides into right and left primary bronchi at the level of the sternal angle (where manubrium and body of sternum meet).
Inhaled objects usually lodge in the right primary bronchus since it is wider, shorter, and at a more vertical angle
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Left lung is smaller, consisting of 2 lobes and contains a cardiac notch
Right lung has 3 lobes FYI: Bronchopulmonary segments
◦ Served by own artery, vein, and individual segmental bronchus
◦ Left lung has 8 segments while right lung has 10.
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Respiratory therapists and surgeons use this info about the different bronchopulmonary segments so they can treat the patient as needed◦ Even to the point of removing the diseased
segment and leaving the good tissue
The lungs weigh approximately 2.5 pounds
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Parietal vs. visceral Function of pleural fluid
◦ Lubricate layers so they can slide across each other
◦ Cause them to cling tightly to each other through surface tension (helps maintain pressure differences necessary for inhaling/exhaling)
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Begins as the terminal bronchioles which feed into the respiratory bronchioles which end in the alveoli chambers where gas exchange (external respiration) takes place.
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Composed of simple squamous – much thinner than a sheet of paper
Membrane has gas on one side and blood on the other.
Account for the largest portion of lung volume and provide a tremendous surface area for gas exchange
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Gas exchanges occur through simple diffusion
Approximate surface area = 50-70 square meters (40x greater than skin SA)
A moist membrane is required so the TYPE II cuboidal cells secrete a substance called surfactant that coats the membrane & interferes with surface tension.
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Pulmonary ventilation: air is moved in and out of the lungs
External respiration: gas exchange between blood and alveoli
Respiratory gas transport: CV system transports oxygen and carbon dioxide between lungs & tissues (discussed in Blood chapter)
Internal respiration: gas exchange between blood & tissue cells Definition: Cellular respiration: actual use of
oxygen & production of carbon dioxide in the cells (this is why we have to breathe!!)
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Pulmonary ventilation: - Moving air into and out of the lungs Depends on pressure changes Breathing Inspiration = moving air into the lungs Expiration = moving air out of lungs
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Intrapulmonary pressure Pressure within the alveoli (lungs) Changes with phases of breathing Always equalizes itself with atmospheric
pressure Intrapleural pressure
Pressure within intrapleural space (between the pleural membranes )
Always 4 mmHg less than intrapulmonary pressure
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Any conditions that causes intrapulmonary pressure to equal intrapleural pressure will cause the lungs to collapse
This means they lose the ability to move air since there is NO more pressure difference
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term for lung collapse
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Air in the intrapleural space due to trauma – causes lung collapse
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Question: Why does breathing happen? ONLY acceptable answer: The RULE:
Volume changes lead to pressure changes which lead to the flow of gases to equalize the pressure
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Boyle’s Law = Pressure & Volume have an INVERSE relationship.
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Main inspiratory muscles Diaphragm & external intercostals
Thoracic dimensions change to increase volume of thoracic cavity by 0.5 liters
Intrapulmonary pressure drops 1-3 mmHg and air rushes info normal quiet inspiration
A deep forced (active) inspiration requires activation of accessory muscles – see diagram in notes
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A passive process dependent on natural lung elasticity
lungs recoil when inspiration stops – so alveoli compress –which leads to a volume
decreases -causing intrapulmonary pressure to rise - gas outflows to equalize the pressure with atmospheric pressure
Forced (active) expiration requires contraction of abdominals, etc – see diagram
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Bronchial sounds: produced by air rushing through trachea & bronchi
Vesicular sounds: produced by air filling alveoli
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Wheezing: whistling sound
Rales: rasping sound
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Basic Lung Sounds – Bronchial Auscultating The Lungs - Reference Guide
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Pulmonary ventilation can be influenced by 4 physical factors Respiratory passage resistance Lung compliance Lung elasticity Alveolar surface tension forces
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Resistance due to increased friction as air moves through passages Smooth muscle
bronchoconstriction Disorders such as asthma – when bronchi constrict
Local accumulations of mucus, infectious material, and tumors – also block air passage
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The ease with which lungs can readily expand
Affected by the elasticity of the lungs and the thoracic cage which can be diminished by 2 main factors: Fibrosis of the lung tissue Ossification and/or muscle paralysis impairs
flexibility of the thoracic cage
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Essential for normal expiration
Emphysema: tissue becomes less elastic and more fibrous loss of elasticity & increase in fibrous tissue
causes enormous effort to exhale – at end stages, alveolar walls break down and surface area is lost for gas exchange
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Surface tension is caused by the tendency of polar molecules such as water to stick to each other with hydrogen bonds
this can cause the walls of the alveoli to stick together like plastic wrap every time you exhale.
Large amounts of energy /effort will be required to simply re-expand the lungs and
allow you to inhale (IRDS)
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Surfactant – interferes with cohesion of water molecules so less energy needed to expand lungs – this is one of the things that keeps our lungs partially expanded at all times. (the other thing is the pressure difference previously discussed)
Secreted by Type II cells in lungs
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AKA: Hyaline Membrane DiseaseCaused by lack of surfactant due to prematurity 28 weeks of gestation is considered
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Measurements made as part of pulmonary function tests;
Volumes that move in and out during the normal breathing cycle, and with deliberate additional effort
can be measured directly by spirometry with the subject breathing through a closed circuit in and out of a cylinder inverted over water, or into a vitalograph, or by pneumotachograph
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Table 1: Lung volumes
Tidal Volume Volume of inspired/expired air moving in and out with each breath
Inspiratory and expiratory reserve volumes
Used when tidal volume increases above that at rest
Vital capacity Volume that can be inspired/expired after full expiration/inspiration
Forced expiratory volume in1s
Volume exhaled in the first second, with maximal effort after full inspiration
Functional residual capacity
Volume remaining in the lungs at end-expiration; decreases as tidal volume increases
Residual volume Remains after a maximal expiratory effort; cannot be exhaled
Total lung capacity Vital capacity + residual volume
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Internal & External RespirationEvents #2 & 4
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Used to determine the individual pressures of each gas in a mixture of gases
Based on % of total of 760 mmHg of total atmospheric pressure
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Gas exchanges that occur: Between the blood and the alveoli AND Between the blood and the tissue cells Take place by simple diffusion Depends on partial pressures of oxygen & carbon
dioxide that exist on opposite sides of the exchange membrane (Dalton’s law of partial pressures)
Always flowing from high to low
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states that the solubility of a gas in a liquid is directly proportional to the pressure of that gas above the surface of the solution (IOW: the higher the pressure of the gas, the more gas will be shoved into the liquid thus increasing solubility)
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Solubility (of a gas) and partial pressure have a direct relationship
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The solubility coefficient of the gas also affects this process – the higher the #, the more the gas “likes” to dissolve into a liquid (based on molecular structure, etc.)
Each gas will dissolve in a liquid in proportion to the ratio between its partial pressure gradient and its solubility coefficient CO2 = .57 O2 = .024 N2 = .012
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Solubility & temperature have an inverse relationship.
Increase in temperature causes increase in kinetic energy causes more molecular motion which allows molecules to break the intermolecular bonds and escape from solution
And vice versa
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Partial pressure gradients and gas solubilities Oxygen = has low
solubility but steep partial pressure gradient (105 mmHg in alveoli – 40 mmHg in blood = 65 mmHg pressure gradient)
Carbon dioxide = has solubility ~20x greater than oxygen but partial pressure gradient is only 5 mmHg
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Partial pressure gradients and gas solubilities Due to the ratios of solubility coefficients and
pressure gradients: ~Equal amounts of gases are exchanged
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Thickness of respiratory membranes 0.5 to 1.0 micrometers edematous (swollen) tissue can be caused by
congestion and pneumonia - hinders diffusion leading to hypoxia oxygen deprivation
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Surface Area 50-70 square
meters for gas exchange
Emphysema or cancer
Walls of alveoli break down
Less surface area for gas exchange
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The phrenic & intercostal nerves transmit impulses to the respiratory muscles Irritation to phrenic
nerve is responsible for hiccups (spasm of diaphragm muscle)
Neural centers are located in medulla & pons
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Eupnea = normal respiration rate Approx 12-15 breaths per min
Hyperpnea = higher than normal rate Apnea = No rate Dyspnea = general term for abnormal rate Physical factors, conscious control,
emotional factors, and chemical factors all influence rate & depth of breathing.
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Deep & rapid respiration, too much CO2 is vented out of the body so:
Not enough acid productionH2O + CO2 = H2CO3 (carbonic acid)
Respiratory alkalosis results Treatment: trap the CO2 and
rebreathe it till breathing returns to normal
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Slow & shallow respiration with not adequate expiration so CO2 is not vented out of the body
Production of excess acid H2O + CO2 = H2CO3 (carbonic acid)
Respiratory acidosis results Usually caused by disease process:
COPD Asthma Obesity Trauma Pneumonia