Kluk, K.*, Tan, C.M.*, Gilpin, H.*, Fitt N.*, John, M.S.**, Picton, T.W.**
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Kluk, K.*, Tan, C.M.*, Gilpin, H.*, Fitt N.*, John, M.S.**, Picton, T.W.** * Human Communication and Deafness Research Group,University of Manchester, Manchester,UK; **Rotman Research Institute, University of Toronto, Toronto, Canada -mail: [email protected] MEASURING TRAINING-INDUCED AUDITORY PLASTICITY USING AUDITORY STEADY-STATE RESPONSES
description
MEASURING TRAINING-INDUCED AUDITORY PLASTICITY USING AUDITORY STEADY-STATE RESPONSES. Kluk, K.*, Tan, C.M.*, Gilpin, H.*, Fitt N.*, John, M.S.**, Picton, T.W.** * Human Communication and Deafness Research Group ,University of Manchester, Manchester,UK; - PowerPoint PPT Presentation
Transcript of Kluk, K.*, Tan, C.M.*, Gilpin, H.*, Fitt N.*, John, M.S.**, Picton, T.W.**
Kluk, K.*, Tan, C.M.*, Gilpin, H.*, Fitt N.*, John, M.S.**, Picton, T.W.**
* Human Communication and Deafness Research Group,University of Manchester, Manchester,UK; **Rotman Research Institute, University of Toronto, Toronto, Canada
E-mail: [email protected]
MEASURING TRAINING-INDUCED AUDITORY PLASTICITY USING
AUDITORY STEADY-STATERESPONSES
INTRODUCTION
Kluk, K. and B.C. Moore, Dead regions in the cochlea and enhancement of frequency discrimination: Effects of audiogram slope, unilateral versus bilateral loss, and hearing-aid use. Hear Res, 2006. 222(1-2): p. 1-15.
Plasticity - re-mapping of the primary auditory cortex - may be induced by deprivation
INTRODUCTIONPlasticity - re-mapping of the primary auditory cortex - may be induced by deprivation or training.
EXPERIMENTAL DESIGN
Normally-hearing, right-handed, non-musicians
R L
ASSRs
Day 1
L
Training
Days 2, 3, and 4
R
ASSRs
Day 5
1 2
EXPERIMENT 1
R L
ASSRs Pitch Training ASSRs
L
100% AM41 & 45 Hz83 & 87 Hz
R L
1 2 kHz 1 kHz
Pure Tone70 dBSPL3 X 2 hours
the same as pre-training
EXPERIMENT 1 Pure Tone results
Training:3 x 2-hour sessions, 24 hours apart5000 presentations of pure tone at 1 kHz3AFC
Right 40 Hz
0 1000 2000
Res
pons
e am
plitu
de (n
V)
0.00
0.02
0.04
0.06
0.08
0.10
0.12
0.14
0.16 Pre-trainingPost-training
EXPERIMENT 1 ASSR Amplitude
Right 80 Hz
Carrier Frequency (Hz)0 1000 2000
Res
pons
e A
mpl
itude
(nV
)
0.00
0.02
0.04
0.06
0.08
0.10
0.12
0.14
0.16Left 80 Hz
Carrier Frequency (Hz)0 1000 2000
Res
pons
e A
mpl
itude
(nV
)
0.00
0.02
0.04
0.06
0.08
0.10
0.12
0.14
0.16
Left 40 Hz
0 1000 2000
Res
pons
e A
mpl
itude
(nV
)
0.00
0.02
0.04
0.06
0.08
0.10
0.12
0.14
0.16
1 2 4
EXPERIMENT 2
R L
ASSRs FM Training ASSRs
L
MM :40 & 80 Hz
R L
2 kHz
FM Tone Modulatedat 10 Hz3 X 2 hours
1 2 4 kHz
the same as pre-training
EXPERIMENT 2 FM results
Training:3 x 2-hour sessions,
24 hours apart2- kHz FM tone modulated at 10-Hz3AFC
EXPERIMENT 2 ASSR Amplitude
1 2 4
EXPERIMENT 3
R L
ASSRs AM Training ASSRs
R
100 % AM40 & 80 Hz
R L
2 kHz
AM Tone Modulated at4, 32, 128 Hz3 X 2 hours
1 2 4 kHz 1 2 4 1 2 4 kHz
the same as pre-training
EXPERIMENT 3 AM results
Training:3 x 2-hour sessions,
24 hours apart2- kHz AM tone4, 32, 128 Hz3AFC
4 Hz
32 Hz128 Hz
Left 40 Hz
Carrier frequncy (kHz)
1 2 41 2 4
Res
pons
e A
mpl
itude
(uV
)
0.0
0.1
0.2
0.3
0.4Pre-trainingPost-training
EXPERIMENT 3 ASSR Amplitude
CONCLUSIONS
1. It is possible to measure training induced plasticity using ASSRs.
2.When Training using Pure Tones or Frequency Modulated Tones improvement on behavioural task is correlated with increased ASSR amplitude.
3.When training using Amplitude Modulated Tones there is no improvement on behavioural task nor an increase in ASSR amplitude.
CONCLUSIONS 4. The increase of the ASSR amplitude after training
may be caused by the reorganization of the
primary auditory cortex and not by better
synchronization of neural firing.
Acknowledgements
• Members and students of Human Communication
and Deafness Research Group, Manchester, UK.
• Faculty of Human and Medical Sciences Start-up
Fund, The University of Manchester, UK
E-mail: [email protected]
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