The Future and All That Jazz: Communicating about AI

Safety with Diverse Audiences using Diverse (and

Surprising!) Means – Poetry, Music, Sound Bytes 

Kim Solez, MD

Rich Sutton (UAlberta) Future of AI meeting Puerto Rico Jan

3, 2015

Acceptance. Share power. The AIs will not all be under our control. They will compete and cooperate with us just like other people, except with greater diversity and asymmetries We need to set up mechanisms (social, legal, political, cultural) to ensure that this works out well Inevitably, conventional humans will be less important Step 1: Lose your sense of entitlementStep 2: Include AIs in your circle of empathy

What Human Beings Will Look Like in 2045!

Nephrologists & Renal Pathologists May Be Only People Still Employed in 2045!

25 years ago Kim Solez and Lorraine Racusen Directed the First Banff Meeting Which Created the Banff Classification of Transplant Pathology

Banff Classification of Kidney Transplant Pathology

Histologic criteria for the diagnosis of rejection and other conditions in the transplanted kidney, began 1991, updated and expanded every two years in consensus meeting.

1991 First Conference 1993 First Kidney International publication 1995 Integration with CADI 1997 Integration with CCTT classification 1999 Second KI paper. Clinical practice guidelines. Implantation biopsies. 2001 Classification of antibody-mediated rejection: Regulatory agencies

participating 2003 Genomics focus, ptc cell accumulation scoring 2005 Gene chip analysis. Elimination of CAN, identification of chronic

antibody-mediated rejection. 2007 First meeting far from a town called “Banff” – La Coruna, Spain. 2009 Working groups. Meeting in Banff, Alberta, Canada 2013 Establishment of Banff Foundation for Allograft Pathology

BANFF Classification - Milestones

Significance of ‘Banff papers’• More than 5,000 citations of the 14 Banff meeting reports• My work has 17,000 citations.• 962 Banff / Transplantation papers in PubMed• Banff 2003 meeting report (ABMR criteria) = most cited

American Journal of Transplantation paper• 3 Banff meeting reports are among the top 4 cited AJT articles

Tissue Engineering Pathology Added Soon!•

The Banff ProcessConsensus communication in renal transplantation

a

The Banff lesions

g, i, t, v - score

The Banff communityPathologistsNephrologistsTx-SurgeonsLab-Medicine

established by

consensus in 1991

The Banff classificationCurrent consensus for diagnostics

moderatedBanff meetings

thesis-antithesis-synthesis

tentative

thresholds

participate

refinementBanff Working Groups

Feedback concerning weaknesses and strengths by results from independent research

New membersBiostaticiansMolecular Biologists“Omics”-specialists

Off-springsLiverPancreasLung, HeartCTA

Organizational structure of the Banff Foundation For Allograft Pathology

Board of Trustees: K. Solez (Chair), L. Racusen, D. Glotz, J. Demetris, M. Mengel, M. Mihatsch, D. Seron

2015 Local Conference chair: Michael Mengel

Organ Steering committee Chairs: Composite tissues: Linda CendalesHeart : Patrick BrunevalKidney: Mark HaasLiver: Jake DemetrisLung: William Wallace and Carol FarverPancreas: Cinthia Drachenberg

Banff Working Group (BWG) Leads: Molecular transplantation pathology: Michael Mengel, Banu SisIsolated v-lesions: Banu Sis, Ed KrausQuality assurance in transplantation diagnostics: Michael Mengel and Parmjeet RandhawaC4d-negative ABMR: Mark Haas, Banu Sis, Alexandre LoupyFibrosis scoring: Robert Colvin, Brad Farris, Michael MengelDigital Pathology in Transplantation: Jake Demetris

2015 Scientific program committee: Alex Loupy (Chair)Mark Haas, Banu Sis, Kathryn Tinkham, Candice Rofousse, Chris Bellamy, Lynn Cornell, Carmen LeFaucheurComposite tissues: Linda CendalesHeart : Patrick BrunevalLiver: Jake DemetrisLung: William Wallace and Carol FarverPancreas/Islets: Cinthia Drachenberg and John Papadimitriou

Secretary/Treasurer: Michael Mengel

funding

collaboration

reports to

reports to

collaboration

collaboration

reports to

collaborationprogress reports to Budged

proposal and accountability for meeting costs

support

The World is Changing Rapidly!

The World is Changing Rapidly!

The World is Changing Rapidly!

The World is Changing Rapidly!

The Technological Singularity

Podocytes go wandering into the interstitium! Song et al.

Song et al. Interstitium, vessels, and glomeruli with missing cells. Disordered tubule formation with multiple interconnecting lumina of differing sizes. “Can you really call this a kidney?” (Yes!)

In our original location we had mule deer poking their heads

into the meeting rooms!We’ve come a long way!

Patricia Bacus: A new profession within pathology: Robot liaison/advocate: The best human friend a robot

ever had!

The pathologist’s continuity of care, Self-aware artificial

intelligence could assert itself at any point!

The pathologist’s continuity of care, Self-aware artificial

intelligence could assert itself at any point!

The pathologist’s continuity of care, Self-aware artificial

intelligence could assert itself at any point!

The pathologist’s continuity of care, Self-aware artificial intelligence could asssert

itself at any point!

The pathologist’s continuity of care, Self-aware artificial

intelligence could assert itself at any point!

The pathologist’s continuity of care, Self-aware artificial

intelligence could assert itself at any point!

Rich Sutton (UAlberta) Future of AI meeting Puerto Rico Jan

3, 2015

Acceptance. Share power. The AIs will not all be under our control. They will compete and cooperate with us just like other people, except with greater diversity and asymmetries We need to set up mechanisms (social, legal, political, cultural) to ensure that this works out well Inevitably, conventional humans will be less important Step 1: Lose your sense of entitlementStep 2: Include AIs in your circle of empathy

Plans Invigorated by Mentoring Award:1. Tissue Engineering Pathology2. Mainstreaming AI & Future Education

(Rich Sutton)3. The Future and All That Jazz (Mallory

Chipman)

The Future and All That Jazz

Future and All That Jazz:1. Two local prototype events January 19th

and March 8th at Rouge Lounge.2. Event planned in London August 16th-

17th. 3. Correcting imbalance between 9,000

people we are reaching & 80 million reached by Big Bang Theory.

Life Sized Cutout of Sheldon (Big Bang Theory) Reminds Us