Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor,...

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Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics, Univ. of Texas Houston Adj. Professor, Oral & Maxillofacial Surgery, Univ. of Texas Houston Founder, OsteoBiologics, Inc. Founder, Xilas Medical, Inc. Founder, VidaCare, Corp. Founder, CyTex, Ltd. T he road ahead must forge through research & commercialization Cyprus Entrepreneurship Competition , Nicosia, Cyprus December 17, 2003

Transcript of Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor,...

Page 1: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

Kyriacos A. AthanasiouPresident, Biomedical Engineering SocietyProfessor, Bioengineering, Rice UniversityAdj. Professor, Orthopaedics, Univ. of

Texas HoustonAdj. Professor, Oral & Maxillofacial

Surgery, Univ. of Texas Houston

Founder, OsteoBiologics, Inc.Founder, Xilas Medical, Inc.Founder, VidaCare, Corp.Founder, CyTex, Ltd.

The road ahead must forge

through research &

commercialization

Cyprus Entrepreneurship Competition,

Nicosia, Cyprus

December 17, 2003

Page 2: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

• Traditional technology transfer paradigm (e.g., OsteoBiologics, Xilas, VidaCare, CyTex)

• A novel approach for commercialization

• Proposal for establishment of a research institute in Cyprus

OUTLINE

Page 3: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

Technology transfer paradigmMODUS OPERANDI

New

technology

New

company

Academic

research

Page 4: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

University-based research leads to an orthopaedic company

Page 5: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

Applied research leads to a diabetes company

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VidaCare Corporation

University-based research leads to an emergency care medical

company

Page 7: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

A company with anti-cholesterol product (natural cocktail of

statins)

Page 8: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

Newtechnology

Technology transfer paradigmPROPOSED

New companies

Centres of Excellence in Applied Research

Development

Corporation

Page 9: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

What do I propose?

INSTITUTE

Centre of Excellence

non-profit

Development Corporation

business

Page 10: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

•Each centre should be based on the pursuit of applied research with commercializable potential

•Centres should be created around particular people – not areas

•The human factor should be the underpinning of this effort

The underlying principles

Page 11: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

• A Centre of Excellence in biomedical research – applied research

• Along with a Development Corporation for technology commercialization

• Areas of concentration: Orthopaedic, Musculoskeletal Tissue Engineering (orthopaedics and maxillofacial), Cardiovascular, and Diabetes

• Disclaimer

Cyprus Biomedical Institute

Page 12: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

Examples of new technologies:

• Biodegradable materials used in orthopaedic applications

• Regeneration of articular cartilage and the meniscus

• Devices related to the prevention of diabetes effects on the lower extremity

• Reduction of blood lipids (e.g., cholesterol and triglycerides)

The Institute:A highly focused effort

Page 13: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

The Centre of Excellence• A traditional, not-for-profit conduit of applied research in few biomedical areas

• Members as research associates – Centre’s key leaders joint academic appointments

• Attract outstanding graduate students and fellows from all over the world – primarily from the University of Cyprus

• Studies: publishable in prestigious, peer-reviewed journals

• Competitive and vigorous pursuit of research grants

Page 14: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

Engineered articular cartilage

Page 15: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

Scaffolds for meniscus regeneration

Page 16: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

The Development Corporation• Business direction; investment fund • Evaluation of research results with

commercialization in mind• Small team (2-3 people) with deep

understanding of entire process • Clear exit strategy aimed at maximizing

returns to investment• 5 years: financial benefits, if mature

technologies selected • Arduous and failure prone process --

one or two success stories… Success breeds success

Page 17: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

BIOMEDICAL INSTITUTE(President, management team)

Development Corporation

business entity

Scientific Advisory Board

Board of Directors

Centre of Excellence

non-profit academic organization

Lab 1 Lab 2 Lab 3Lab 4

Page 18: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

• Dual mission of Institute:

• Act as a repository of research projects at the cutting edge of applied biomedicine•Few, well-respected, outstanding, pre-selected people•Only a few biomedical areas•Active laboratories •Competitive grants•Work presented at international forums

• Be a financial success•Self-sustained•One financially and commercially viable company

Success criteria

Page 19: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

THE PLAN• People-centred Institute• Focused & sustained effort• Applied research in Cyprus recognized to be on par with that of best centres in the world

• Change perception of Cyprus as lacking innovative, biomedical industry

• Convince investors that Cyprus is a suitable place for investment in biomedicine

• Be a financial success• Diversification of the Cyprus economy

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Musculoskeletal Bioengineering

Page 21: Khkhkhkhkhkhkhkhkh Kyriacos A. Athanasiou President, Biomedical Engineering Society Professor, Bioengineering, Rice University Adj. Professor, Orthopaedics,

National Institutes of Health, NHTSA, Binational Science Foundation, Arthritis Foundation, Whitaker Foundation, Industrial sources (Arthrex, OsteoBiologics, DePuy, Nutramax, VidaCare, Xilas)

Funding from: