KenaLeen Cream and Vitiligo

8/16/2019 KenaLeen Cream and Vitiligo

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KenaRoots


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Chronic skin disease Other name = Leukoderma White spots occur when the skin

no longer forms melanin(pigment that determines thecolor of your skin, hair, and eyes)

The white patches of irregularshapes begin to appear on yourskin


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White patches of skin Whitening or graying of the hair on your

scalp, eyelashes, eyebrows or beard

Loss of color in the tissues that line theinside of your mouth Loss or change in color of the inner layer of

your eye


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Chalk white color Con e! margins

"mm to "cm ormore in diameter #ound, o al, or

elongated in shape AVRF

http://www.avrf.org/index.htmhttp://www.avrf.org/index.htm


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Focal pattern $the depigmentation is limitedto one or only a few areas

Segmental pattern $depigmented patchesde elop on only one side of the body

Generalized pattern $(most common)depigmentation occurs symmetrically on bothsides of the body

%ocal and segmental patterns do not spread&The generali'ed pattern is hard to predict andcan randomly stop


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Can appear at any age, usually first appears between the ages of and *

White patches may begin on your face abo e your eyes or on your neck, armpits, elbows,genitals, hands or knees

+ + of the world population de elops -ffects both genders and all races e.ually


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When no melanin isproduced, the in ol ed patchof skin becomes white

When a white patch grows orspreads the cause may be /itiligo

0!act cause is unknown 1ay be due to an immune

disorder, heredity, oren ironmental causes likesunburn or emotionaldistress that trigger thecondition


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- family history of itiligo

Look to see if there is arash, sunburn, or otherskin trauma that hasoccurred within or *months afterpigmentation wasdisco ered

2remature graying ofthe hair (before age *")

3tress or physicalillness

-lso they may ask foran eye e!amination(inflammation of youreye) and4or blood test(autoimmune disease)


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/itiligo is difficult to treat0arly treatment options include5

0!posure to intense ultra iolet light, such as narrow band6/7 therapy1edicines taken by mouth such as trimethylpsoralen(Trisoralen)

1edicines5Corticosteroid creams

8mmunosuppressants such as pimecrolimus (0lidel )and tacrolimus (2rotopic )#epigmenting agents such as metho!salen (O!soralen )

http://www.drugs.com/cdi/pimecrolimus.htmlhttp://www.drugs.com/elidel.htmlhttp://www.drugs.com/cdi/tacrolimus-ointment.htmlhttp://www.drugs.com/protopic.htmlhttp://www.drugs.com/cdi/methoxsalen-lotion.htmlhttp://www.drugs.com/cdi/oxsoralen-lotion.htmlhttp://www.drugs.com/cdi/oxsoralen-lotion.htmlhttp://www.drugs.com/cdi/methoxsalen-lotion.htmlhttp://www.drugs.com/protopic.htmlhttp://www.drugs.com/cdi/tacrolimus-ointment.htmlhttp://www.drugs.com/elidel.htmlhttp://www.drugs.com/cdi/pimecrolimus.html


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The use of steroid creams may be helpful in returning thecolor to the white patches

9octors often prescribe a mild topical corticosteroid creamfor children under + years old and a stronger one foradults

Cream must be applied to the white patches on the skin forat least * months before seeing any results

Corticosteriod creams are the simplest and safesttreatment for itiligo, but are not as effecti e as psoralen

photochemotherapy 3890 0%%0CT3 occur in areas where the skin is thin, suchas on the face and armpits, or in the genital region

› They can be minimi'ed by using weaker formulations of steroidcreams in these areas&


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Topical Calcineurin 8nhibitor s

RDNL

http://bp1.blogger.com/_PGA3lXdSci4/SBWkhQLlZ9I/AAAAAAAAAIc/MLNTgVOj4mo/s1600-h/Elidel+pimecrolimus+cream+vitiligo.jpghttp://www.rdnl.net/http://bp1.blogger.com/_PGA3lXdSci4/SBWkhQLlZ9I/AAAAAAAAAIc/MLNTgVOj4mo/s1600-h/Elidel+pimecrolimus+cream+vitiligo.jpghttp://www.rdnl.net/


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AVRF

http://www.avrf.org/index.htmhttp://www.uvbiotek.com/avrfhttp://www.avrf.org/index.htm


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1ost effecti e treatmenta ailable in the 6nited 3tates&

26/- therapy is to repigment the white patches

time consuming, and care must

be taken to a oid side effects 2soralen is a drug that containschemicals that react withultra iolet light to causedarkening of the skin&

2soralen is in:ected orally or isapplied to the skin

Then skin is carefully timede!posure to sunlight or toultra iolet - (6/-) light thatcomes from a special lamp&

WWHT Dermatology

http://www.westhertshospitals.nhs.uk/dermatology/light_treatment.asphttp://www.westhertshospitals.nhs.uk/dermatology/light_treatment.asp


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6sed for children years old and older who ha e small number white spots ina few areas

Treatments are done under an artificial 6/- light once or twice a week& 2soralen is applied to your depigmented patches about * minutes before

e!posing you to enough 6/- light to turn the affected area pink&

The doctor usually increases the dose of 6/- light slowly o er many weeks& 0 entually, the pink areas fade and a more normal skin color appears& SIDE EFFECTS:

› (+) se ere sunburn and blistering› ( ) too much repigmentation or darkening (hyperpigmentation) of the

treated patches or the normal skin surrounding the itiligo&

%or people with e!tensi e itiligo (affecting more than percent of the body)or for people who do not respond to topical 26/- therapy

;ot recommended for children under + years of age because it increases therisk of damage to the eyes caused by conditions such as cataracts&


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6sed for people with small patches of itiligo The doctor remo es sections of the normal, pigmented

skin and places them on the depigmented areas 8nfections may occur at the donor or recipient sites The recipient and donor sites may de elop scarring, a

cobblestone appearance, or a spotty pigmentation, ormay fail to cure the white spot area

Takes time and is ery costly

9octor creates blisters on your pigmented skin byusing heat, suction, or free'ing cold

The tops of the blisters are then cut out andtransplanted to a depigmented skin area

3890 0%%0CT35 scarring and lack of repigmentation Less risk of scarring with this procedure than with

other types of grafting&


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8mplanting pigment into the skin with a special surgical instrument Works best for the lip area, particularly in people with dark skin 9ifficult to match perfectly the color of the skin of the surrounding

area

The tattooed area will not change in color when e!posed to sun, whilethe surrounding normal skin will& Tattooing tends to fade o er time -lso tattooing of the lips may lead to episodes of blister outbreaks

caused by the herpes simple! irus

Takes a sample of your normal pigmented skin and places itin a laboratory dish containing a special cell culture solutionto grow melanocytes&

When the melanocytes in the culture solution ha emultiplied, the doctor transplants them to your depigmentedskin patches

Currently e!perimental and is impractical for the routine careof people with itiligo

/ery e!pensi e and its side effects are not known&


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Sunscree

n elps protect the skinfrom sunburn and longterm damage

1inimi'es tanning, which makes thecontrast between normaland depigmented skinless noticeable

7lue Li'ard 7aby>3ensiti e 3unscreen

AVRF

http://www.avrf.org/index.htmhttp://www.crownlaboratories.com/bluelizard/advertising.htmlhttp://www.avrf.org/index.htm


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Some vitiligo patients cover depigmented patches with stains, maklotions.

Dermablend, Lydia O’Leary, lini!ue, "ashion "lair, #itadye, and dyes that you may find helpful for covering up depigmented patche

Self tanning lotions have an advantage over makeup in that the coldays and will not come off with washing.

AVRF



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AVRF

April



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+);ational /itiligo %oundation

) /itiligo 3upport 8nternational*) -merican /itiligo #esearch %oundation 8nc&

SUPPORT

organizations

http://nvfi.org/index.phphttp://www.vitiligosupport.org/http://www.avrf.org/index.htmhttp://www.avrf.org/index.htmhttp://www.avrf.org/diversity/contributions.phphttp://www.avrf.org/index.htmhttp://www.avrf.org/index.htmhttp://www.vitiligosupport.org/http://nvfi.org/index.php


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;ation Library of 1edicine (1edicine 2lus) -merican /itiligo #esearch %oundation ;ational 8nstitutes of ealth, 9epartment of ealth an

d uman 3er ices 5 ;ational 8nstitute of -rthritis and 1usculoskeletaland 3kin 9iseases

9rugs&com (Treatments) youtube&com (Lee Thomas Turning White 4

8nter iew) ;ational /itiligo %oundation ( ideo gallery 0li'abeth

/argas 8nter iew)

http://www.avrf.org/index.htmhttp://www.niams.nih.gov/health_info/Vitiligo/default.asphttp://www.niams.nih.gov/health_info/Vitiligo/default.asphttp://www.drugs.com/enc/vitiligo.htmlhttp://www.youtube.com/watch?v=EIyQvcuTJYAhttp://nvfi.org/pages/video_gallery.phphttp://nvfi.org/pages/video_gallery.phphttp://www.youtube.com/watch?v=EIyQvcuTJYAhttp://www.drugs.com/enc/vitiligo.htmlhttp://www.niams.nih.gov/health_info/Vitiligo/default.asphttp://www.niams.nih.gov/health_info/Vitiligo/default.asphttp://www.avrf.org/index.htm


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+) ;ational /itiligo %oundation) -merican /itiligo #esearch %oundation 8nc&

*) /isuald!health?) #e olution ealth") WW T 9ermatology@)0lidelA) ;ational /itiligo %oundationB) /itiligo 3upport 8nternational

http://nvfi.org/pages/video_gallery.phphttp://www.avrf.org/index.htmhttp://www.visualdxhealth.com/adult/vitiligo.htmhttp://www.visualdxhealth.com/adult/vitiligo.htmhttp://www.avrf.org/index.htmhttp://nvfi.org/pages/video_gallery.php


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Lee Thomas

Ki s !oping "ith

Vitiligo

#liza$eth Vargas%nter&ie"


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Ingredient Main activesubstance

Action

Cocos nucifera oil

Coconut oilcontains essentialsaturated andunsaturated fattyacids, Highconcentration of

Vitamin E and K,high concentrationof Zinc and Iron.

Coconut oil is theonly ty e of oil that

one should use onone!s s"in for it isabsorbed easilyand "ee s the s"insoft# Coconut oilcontains Vitamin E

Al ha $oco herol#$his "ind ofVitamin is a %ell&"no%n otentantio'idant and isbene(cial to the

s"in.


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Action

)soralea

corylifolia e'tract

)soralea

corylifolia contains*avons,iso*avons,furanocoumarins,chalcones andcoumesterol grou

of com ounds%hich includessoralen,

iso soralen andbavichinin+.

Psoralea corylifolia appears tohave a purely local action with a

speci c e ect on the arterioles ofthe subcapillary plexuses, whichare dilated so that the plasma isincreased in this area. he s!inbecomes red and themelanoblasts "pi#ment$formin#cells% are stimulated. &nleu!oderma, melanoblasts do notfunction properly and theirstimulation by the dru# leads

them to form and exudatepi#ments, which #radually di useinto the white leu!odermicpatches.' Also, thephytochemically induced covalentbindin# of the dru# to pyrimidinebases is responsible for itstherapeutic e ect. hephotocon(unction involves thyminedimer adducts on the oppositestrands of )*A. Psoralen has beenfound to intercalate into )*A,where they form mono$ and di$adducts in the presence of lon#wavelen#th +V li#ht and thus areused for the treatment of hypo$pi#mented lesions of the s!in,such as leu!oderma.


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Action

erberis vulgaris

root e'tract

arberry includessuch al!aloids asberbamine, berberine,oxyacanthine, resinand tannins, andchelidonic acid.

arberry Root alsoconstituents the $vitamin thiamine,vitamin -, lutein,

eaxanthin, thecarotenoids beta$

carotene, chromium,inc, and cobalt.

arberry root hasantioxidant and

cytoprotectiveproperties.


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Action

)icrorhi-a "urroaroot e'tract

Picrorhi a !urroa rootextract contains/ut!in, )$0annitol

and Vanillic acid

Picrorhi a !urroa wasfound to be a potentimmunostimulant ofboth cell$mediatedand humoralimmunity. picrorhi a

was reported tostimulate cellmediated andhumoral componentsof the immunesystem includin#

stimulation ofpha#ocytosis.


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Action

MelaleucaAlternifolia.$ea$ree/ 0eaf 1il

erpineol , -ineol ,Pinene , erpinenes

)o%erful and broads ectrum anti&microbial agent.Anti&bacterial,anti&fungal andanti&mycotic

agent/, and it hasan immune systemstimulant e2ect


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Action

Emu oil 0inolinic acis and1leic acid

+sed by theAbori#inal people ofAustralia for thetreatment of muscleand (oint pain,contains a variety offatty acids. 0odernresearch into theproperties of emu oilhas found that this isthe #reatest s!inemollient in theworld, with deep s!inpenetrationproperties better than

any other natural oil.


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Action

Vitamin E.$oco herol/

Al ha&toco herol )o%erful anti&o'idant agent


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*atural pathway for P+VA therapy. Rich source of natural powerful anti$

oxidants. Rich source of essential minerals and

vitamins for vitili#o patients.

2afe with minor side e ects. -ost e ective.


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KenaLeen Cream and Vitiligo

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