INSIGHT2016 ANNUAL REPORT

KECK SCHOOL OF MEDICINE OF USCDEPARTMENT OF OPHTHALMOLOGY

Gayle and Edward Roski made a transformative $25 million gift in 2016 to endow and name the USC Roski Eye Institute, further advancing the institute’s position as one of the nation’s leading centers for advanced vision care, research and education.

“ Our gratitude to the Roski family is profound. With this gift, we will continue to

make progress toward our most ambitious goal — eliminating blindness.” Rohit Varma, MD, MPH, Director, USC Roski Eye Institute

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INSIGHT is the driving force behind everything we do at the USC Roski Eye Institute.Insight begins with envisioning a future without blindness.

Insight grows by learning from each courageous patient.

Insight deepens through continual discovery and invention.

Insight triumphs when we come together to preserve vision.

Insight renews as each new generation seeks and serves.

INSIGHT 2016 provides a glimpse into the accomplishments of our 41st year.

We are deeply indebted to the patients, families, philanthropists, physicians,

scientists, researchers, caregivers, residents, technicians, entrepreneurs,

administrators, managers, and countless others who join us in our mission to

eliminate blindness. All of you make the USC Roski Eye Institute everything it is,

and everything it will be.

With gratitude,

Rohit Varma, MD, MPH

Dean, Keck School of Medicine of USC May S. and John Hooval Dean’s Chair in Medicine Grace and Emery Beardsley Chair in Ophthalmology Director, USC Roski Eye Institute

(Opposite page, from left) Rohit Varma, Edward P. Roski Jr., Gayle Garner Roski, Robert Day, Niki Nikias, USC President C.L. Max Nikias, and Mark Humayun give the USC “Fight On” sign.

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VISION IS OUR MISSIONPRESERVE. PROTECT. RESTORE.

PRESERVE

The USC Roski Eye Institute diagnoses, treats and manages the most complex eye conditions, from in utero to advanced age.

Fulfillment of our mission is best expressed in the remarkable triumphs of our patients. Please read their stories in the pages ahead.

PROTECT

The USC Roski Eye Institute leads major research in the epidemiology of eye disease to help prevent blindness.

RESTORE

The USC Roski Eye Institute integrates and applies emerging technologies to develop new methods to restore sight to the blind.

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VISION IS OUR MISSIONPRESERVE. PROTECT. RESTORE.

Patient Care 6

Research 18

Preserving Sight 32

Clinical Education 37

Publications 50

INSIGHT2016 ANNUAL REPORT

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2016 AAO LIFE ACHIEVEMENT HONOR

AWARD

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Rohit Varma, MD, MPH, director, USC Roski Eye Institute, was presented with the award at the 2016 American Academy of Ophthalmology conference in Chicago.

Nation’s Best Hospitals for Ophthalmology

2016-17 Nationally Top Ranked Ophthalmology Program

BEST DOCTORS IN AMERICA®

2015-16Four USC Roski Eye Institute faculty

named among the best

#2 IN RESEARCH FUNDING 2016

by the National Eye Institute

World’s 100 Most Influential People in OphthalmologyAwarded by The Ophthalmologist From left, Carmen Puliafito, MD, MBA, Mark S. Humayun,

MD, PhD, and Farhad Hafezi, MD, PhD.

MAJOR ACCOLADES AND ACHIEVEMENTS

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#9 U.S. Ophthalmology

Residency Program 2016 by Doximity

SUPER DOCTORS OF SOUTHERN CALIFORNIA 2016

13 USC Roski Eye Institute faculty named among the best

National Medal of Technology

and Innovation The nation’s highest honor for

technology achievement

President Barack Obama and National Medal recipient Mark S. Humayun, MD, PhD, co-director of the USC Roski Eye Institute and director of the USC Institute for Biomedical Therapeutics.

NEW TEXTBOOKS FROM USC ROSKI EYE INSTITUTE FACULTY 2016

(Left to right) Advanced Glaucoma Surgery Editors: Ahmad A. Aref  and Rohit Varma; Clinical Neuro-Ophthalmology: The Essentials Authors: Neil R. Miller, Prem S. Subramanian and Vivek Patel; Corneal Collagen Cross-Linking (translated into Chinese) Authors: Farhad Hafezi and J. Bradley Randleman; Corneal Cross-Linking Editors: Farhad Hafezi and J. Bradley Randleman; Intraocular Inflammation Editors: Manfred Zierhut, Carlos Pavesio, Shigeaki Ohno, Fernando Orefice, Narsing A. Rao; Intraocular Lens Surgery Editor: J. Bradley Randleman; Optical Coherence Tomography and OCT Angiography Authors: Darrin A. Landry and Amir H. Kashani.

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INSIGHT

Patient CareThe USC Roski Eye Institute is dedicated to managing or curing eye conditions by applying the most advanced knowledge, skills, technologies and methods.

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CATARACTS

CORNEA AND EXTERNAL DISEASES

Blepharitis, Bullous Keratopathy, Chalazia/Styes, Conjunctivitis, Corneal Dystrophies, Fuchs Endothelial Dystrophy, Corneal Infection, Corneal Scarring, Dry Eye Syndrome, Herpes Keratitis, Keratoconus, Pterygium, Ocular Rosacea

GLAUCOMA

Angle Closure Glaucoma, Open-Angle Glaucoma, Congenital and Childhood Glaucoma, Pseudoexfoliation Glaucoma, Glaucoma Secondary to Eye Trauma, Neovascular Glaucoma, Normal Tension Glaucoma, Pigment Dispersion Glaucoma, Uveitic Glaucoma

LASER VISION CORRECTION

Anisometropia, Astigmatism, Hyperopia, Keratoconus, Myopia, Presbyopia

NEURO-OPHTHLAMOLOGY AND ADULT STRABISMUS

Blepharospasm, Double Vision, Hemifacial Spasm, Idiopathic Intracranial Hypertension, Optic Neuropathy, Papilledema, Stroke, Temporal Arteritis, Thyroid Eye Disease, Visual Field Defects

OCULAR ONCOLOGY

Anterior Segment and Iris Tumors, Basal Cell Carcinoma, Conjunctival Tumors, Conjunctival Melanoma, Lid Tumors, Lymphoma, Melanoma, Metastatic Lesions, Ocular Surface Squamous Neoplasia, Optic Nerve Lesions, Orbital Lesions, Sebaceous Cell Carcinoma of the Lid, Squamous Cell Carcinoma, Vascular Lesions, Uveal Lesions

OCULOFACIAL PLASTIC SURGERY

OPHTHALMIC MOLECULAR AND IMMUNOPATHOLOGY

PEDIATRIC OPHTHALMOLOGY

SPECIALTY CONTACT LENSES AND PROSE

UVEITIS AND OCULAR INFLAMMATION

Chorioretinitis, Herpetic Uveitis, HLA-B27 Iridocyclitis, Ocular Tuberculosis, Toxoplasmosis, Vogt-Koyanagi-Harada Disease

VITREORETINAL SURGERY AND RETINAL DISEASE

Age-related Macular Degeneration (Wet and Dry), Central Serous Chorioretinopathy, Diabetic Macular Edema, Diabetic Retinopathy, Macular Hole, Macular Pucker, Posterior Vitreous Detachment, Retinal Detachment, Retinal Tears, Retinal Vein Occlusion, Retinitis Pigmentosa

HIGHLY SPECIALIZED CARE FOR ADULTS AND CHILDREN

PATIENT CARE

The USC Roski Eye Institute treats the full spectrum of eye conditions — from the most common to the most complex.

109,461TOTAL

PATIENT VISITS

256 PEER-REVIEWED

PUBLICATIONS

WORLD WIDEPATIENT CARE

125FACULTY MEMBERS

36ACTIVE RESEARCH GRANTS

$56.3MILLION

FEDERAL GRANT EXPENDITURES

U S C E Y E . O R G

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Legally blind for most of her life, Jessica Marquez began the battle to save her vision as a young child. An extreme sensitivity to light and poor eyesight led to a diagnosis of glaucoma and cloudy corneas in both eyes. Over the years, treatment for Jessica’s condition included surgeries and setbacks that took a further toll on her vision.

Jessica eventually came to the USC Roski Eye Institute in hopes that her vision could be saved. A team of corneal, retinal and glaucoma specialists examined Jessica and developed a comprehensive plan to maximize the efficiency of treatment while reducing further trauma to her eyes. Her eye pressure is now under control and her eyesight has been preserved.

Despite having very little vision and enduring more than 40 eye surgeries, Jessica has achieved remarkable success. With her parent’s loving support, she kept her eyes on the future. She excelled in school, eventually earning a master’s degree and becoming a professor who teaches public speaking at Orange Coast College. “Education is power,” Jessica says. “Don’t let anything stand in your way.”

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Jessica Marquez

Congenital Glaucoma Corneal Edema/CloudinessOCULAR HISTORYPrevious treatment for glaucoma. Failed corneal transplant left significant scar tissue in right eye.

TREATMENTFull thickness corneal transplant and glaucoma valve revision.

OUTCOMECornea is clear in right eye. Vision improved dramatically.

Top image shows a normal optic nerve head. Bottom image shows damage to the optic nerve head from glaucomatous cupping.

Growing up with severe vision problems, Jessica never thought of herself as different.

Alena Reznik, MD, Amir Kashani, MD, PhD, and Jonathan Song, MD, are working together to preserve Jessica’s vision.

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I found great hope in the atmosphere here because I always feel like I am part of the family.

Jessica Marquez ” “

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REVOLUTIONIZING GLAUCOMA SURGERYApproved this year by the FDA, the new XEN® Glaucoma Treatment System redefines surgical intervention for glaucoma through the innovative application of a permanent, flexible implant that drains eye fluid to reduce intraocular pressure.

Developed by USC alumnus and entrepreneur Ron Bache, ’91 with scientific support from Rohit Varma, MD, MPH, the XEN gel stent was proven in large clinical trials to be effective with minimal side effects. Surgical implantation with a specially developed injector applicator simplifies and standardizes the procedure for optimal results that are easily replicated.

This revolutionary intervention has great potential to preserve vision for the nearly 80 billion people worldwide who are estimated to have or who will develop glaucoma by 2020.   

Rohit Varma, MD, MPH

Ron Bache, BS

The XEN® Glaucoma Treatment System reduces intraocular eye pressure with a tiny flexible stent that is implanted using an injector applicator.

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ADVANCING CORNEAL CROSS-LINKINGApproved this year by the FDA, corneal cross-linking (CXL) is an innovative procedure that provides effective treatment for keratoconus, an eye disease that destroys vision by distorting the cornea into a cone shape.

In the clinic, J. Bradley Randleman, MD, was a principal investigator for two FDA-sponsored U.S. clinical trials demonstrating that CXL can stabilize the cornea and halt the progression of the disease. In the field, Farhad Hafezi, MD, PhD, is leading a clinical study on the incidence of keratoconus in Saudi Arabia, where the disease is believed to be more prevalent.

Together, these USC Roski USC Eye Institute researchers are working to overcome a disease that is the leading cause of severe visual impairment among children and adults worldwide. 

J. Bradley Randleman, MD

Farhad Hafezi, MD, PhD

PATIENT CARE

J. Bradley Randleman, MD, performs the CXL procedure that uses a combination of ultraviolet-A light irradiation and application of riboflavin (vitamin B2) eye drops to stabilize the cornea.

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Keratoconus

OCULAR HISTORYGood vision in left eye with contact lens after corneal transplant 10 years ago. Poor vision in right eye from keratoconus. Contact lens intolerant.

TREATMENTUnderwent corneal cross-linking (CXL), a new treatment for keratoconus that stops the progression of the disease and can partially reverse some of the corneal changes.

OUTCOMEIn the healing phase and doing well.

With his cornea changing shape from keratoconus, Adam’s vision in his right eye worsened and he was no longer able to wear a contact lens. Jonathan Song, MD, examined Adam and recommended an innovative procedure called corneal cross-linking (CXL). The USC Roski Eye Institute is the first site in the Los Angeles region to have the approved device and offer CXL treatment.

CXL, recently approved by the FDA for use in the United States, is the first and only treatment that can actually halt the progression of keratoconus, and in some cases can partially reverse it. J. Bradley Randleman, MD, performed the procedure on Adam, which consists of dispersing riboflavin eye drops for 30 minutes followed by another 30 minutes of exposure to ultraviolet light.

The procedure was effective in helping to reshape the cornea. Adam’s eye is healing well and his vision is improving.

Adam Lyons

Adam enjoys travel and outdoor activities with his family.

Image of the cornea during CXL treatment. The green glow of the cornea results from the yellow riboflavin drops fluorescing under the blue ultraviolet light.

J. Bradley Randleman, MD, left, performed the CXL procedure on Adam’s right eye, and Jonathan Song, MD, previously performed a corneal transplant on his left eye.

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I’ve been in good hands throughout my exams, the corneal transplant and the new corneal cross-linking treament.

Adam Lyons ” “

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EVALUATING FITNESS-TRACKING EYEWEARImagine if eyeglasses could provide an edge in improving overall health. An innovative product that seamlessly integrates fitness-tracking technology into an optical frame is being distributed through the USC Roski Eye Institute as part of a pilot study.

The fashion-forward eyeglasses measure a wearer’s steps, calories burned, distance traveled and activity, and connect wirelessly to track progress through an accompanying smartphone application.

Gloria Chiu, OD, FAAO, FSLS, who leads the study’s eye care team, believes the eyeglasses will provide more reliable and consistent tracking than wristbands that are subject to vigorous hand movement or not being worn. The result is better vision and better fitness.

Gloria Chiu, OD, FAAO, FSLS

The eyeglasses, developed by VSP Global in partnership with the USC Center for Body Computing, are shown here with a clear temple that reveals the hidden accelerometer, magnetometer and gyroscope that provide biometric measurement.

“ The result is better vision and better fitness.”

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LAUNCHING THE RETINAL DEGENERATION CENTER Children and adults who inherit retinitis pigmentosa (RP) and similar conditions now have greater resources to help preserve their sight. The new Retinal Degeneration Center at the USC Roski Eye Institute combines clinical care and research to deliver a full spectrum of specialized care for these rare and potentially blinding diseases.

Through comprehensive ophthalmic electrophysiology testing, specialists diagnose RP, cone dystrophy, Usher syndrome, Stargardt disease, Best disease, choroideremia and achromatopsia, and then develop effective personalized treatment plans.

The center also conducts clinical and basic science research into gene therapy, stem cell–based therapies and retinal prosthesis, including the Argus II retinal prosthesis for advanced stages of RP. The result is better care today and more possibilities for tomorrow. Mark Borchert, MD

Hossein Ameri, MD, PhD

PATIENT CARE

The new Retinal Degeneration Center surrounds patients with advanced clinical care and breakthrough research.

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PROVIDING OPHTHALMIC PATHOLOGY EXPERTISE The USC Roski Eye Institute Ophthalmic Molecular and Immuno-Pathology laboratory, one of the few in the country, continues to expand. It excels in the study of delicate, often minute tissue samples, and provides an important resource for clinicians, educators and researchers.

An eye pathology fellowship was inaugurated in 2016 with the appointment of fellow Lei-Chi Wang, MD, an investigator from Taiwan, and a new eye pathology rotation delivers more robust diagnostic training.

The laboratory also added a medical examiner to support forensic investigations. In child abuse cases, for example, analysis of retinal bleeding can determine whether abuse is recent or recurring.

In its scope and size, the pathology laboratory is growing to meet increasing needs.

Narsing A. Rao, MD

Laboratory Director Narsing A. Rao, MD, promotes its local and global reach in clinical care, education and research.

Images of an injured eye examined for a forensic investigation.

“ The pathology laboratory is growing to meet increasing needs.”

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SAVING SIGHT VIRTUALLY ANYWHEREThe USC Roski Eye Institute is using virtual reality, artificial intelligence and wearable sensors to provide on-demand, 24/7, global access to expert eye care and information. This is made possible by becoming the first clinical partner in the Virtual Care Clinic program being developed by the USC Center for Body Computing.

Using a smartphone or tablet, patients can interact with “virtual doctor” avatars of USC Roski Eye Institute specialists, watch videos explaining diagnosis and use wearable sensors to track response to medication or treatments. On-demand eye care will not only increase convenience for patients, but will also provide access to the highest levels of ophthalmology expertise and care where it is currently unavailable.

Top: Rohit Varma, MD, MPH, in the Virtual Care Clinic photo scanning booth. Bottom: “Virtual doctor” avatars of Varma and Leslie Saxon, MD, executive director of the USC Center for Body Computing

Advanced technologies will connect USC Roski Eye Institute specialists with patients at any location.

PATIENT CARE

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INSIGHT

ResearchThe USC Roski Eye Institute improves lives through scientific discovery and technical innovation that results in new treatments that overcome visual impairment and blindness.

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HONORING A PASSION FOR INNOVATIONAs a child, Mark S. Humayun decided to dedicate his life to studying ophthalmology after helplessly watching his grandmother go blind. Decades later, he received the nation’s highest technology award for leadership in bridging medicine and engineering to help restore eyesight.

Humayun is best known for his role in developing Argus II, the only FDA-approved retinal prosthesis system that enables people with certain blinding diseases to regain some useful vision. Beyond pursuing further refinement of the artificial retina, Humayun is leading a multi-university consortium to develop a stem cell implant for age-related macular degeneration.

President Barack Obama presented the National Medal of Technology and Innovation to Mark Humayun, MD, PhD, at the White House on May 19, 2016.

“ The knowledge produced by these Americans today will carry our country’s legacy of innovation forward and continue to help countless others around the world.” President Barack Obama on the recipients of the National Medal of Technology and Innovation

RESEARCH

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Active Research Funding as of December 2016

PROJECT SOURCE PRINCIPAL INVESTIGATOR

Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease NIH Amir Kashani, MD, PhD

Functional Imaging in Hypoxic-Ischemic Retinal Disease NIH Amir Kashani, MD, PhD

Study of Subretinal Implantation of Human Embryonic Stem Cell-Derived RPE Cells in Advanced Dry AMD CIRM Amir Kashani, MD, PhD

OCT Angiography Research Consortium (OARC) Carl Zeiss Meditec, Inc. Amir Kashani, MD, PhD

Hyperspectral OCT System for Metabolic Retinal Imaging USC Amir Kashani, MD, PhD

Optimizing Stimulation Strategies for Cortical Visual Prostheses U.S. Army Andrew Weitz, PhD

Restoring Vision By Sheet Transplants of Retinal Progenitors and Retinal Pigment Epithelium (RPE) Derived from Human Embryonic Stem Cells (hESCs) CIRM Biju Thomas, PhD

Studies on Functionality of iPS-RPE Transplanted in Immunodeficient RCS Rats BrightFocus Foundation Biju Thomas, PhD

Parylene for Subconjunctival Patch Grafts and for Continuous Intraocular Pressure Sensors Whittier Foundation Damien Rodger, MD, PhD

An Experimental Approach to Maculopathy NIH David Hinton, MD

Research to Prevent Blindness Career Development Award RPB J. Martin Heur, MD, PhD

Mentoring for the Advancement of Physician-Scientists Award AGS Grace Richter, MD, MPH

Novel Ultra-Flexible Hybrid Circuits for Intracular Retinal Prostheses NIH James Weiland, PhD

Experimental and Clinical Investigations of Retinal Stimulation NIH James Weiland, PhD

INSPIRE: Bioelectronic Systems for Investigating Neural Plasticity NSF James Weiland, PhD

EFRI-BioFlex: Hybrid Polymer-Paper Based Multi-Sensor Implants for Continuous Remote Monitoring NSF James Weiland, PhD

Human Connectomes in Low Vision, Blindness and Sight Restoration NIH James Weiland, PhD

Retinal Prosthesis Neural Imaging: Measuring the Impact of Crossmodal Plasticity on Visual Restoration (Arnold O. Beckman Postdoctoral Fellow: Noelle Stiles) Beckman Foundation James Weiland, PhD

Enhanced Biocompatible Materials for the Repair of Ocular Injuries U.S. Army John Whalen, PhD

Retinal Nanophotoswitch NSF Mark Humayun, MD, PhD

Phase 1 Safety Assessment of CPCB-RPE1, hESC-derived RPE Cell Coated Parylene Membrane Implants, in Patients with Advanced Dry Age Related Macular Degeneration CIRM Mark Humayun, MD, PhD

Thermoresponsive Reversible Adhesive for Temporary Intervention of Ocular Trauma - II U.S. Army Mark Humayun, MD, PhD

Dual-frequency Intravascular Arrays for Functional Imaging of Atherosclerosis NIH Qifa Zhou, PhD

Characterizing Atherosclerosis by Integrated Multimodality Imaging System NIH Qifa Zhou, PhD

Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration NIH Qifa Zhou, PhD

High Resolution Elastography of Retina Under Prosthetic Electrical Stimulation NIH Qifa Zhou, PhD

Phase Resolved ARF Optical Coherence Elastography for Intravascular Imaging NIH Qifa Zhou, PhD

Mexican American Glaucoma Genetic Study NIH Rohit Varma, MD, MPH

African American Eye Disease Study NIH Rohit Varma, MD, MPH

Primary Open Angle African-American Glaucoma Genetics NIH Rohit Varma, MD, MPH

Research to Prevent Blindness (RPB) Unrestricted RPB Rohit Varma, MD, MPH

Novel Stem Cell Therapy for Dry Eye Syndrome with Enhanced Viability and Long-Term Efficacy RPB Sarah Hamm-Alvarez, PhD

Tear fluid and serum levels of Cathepsin S and its endogenous inhibitor Cystatin C as biomarkers for Sjögren's Syndrome

Sjögren's Syndrome Foundation

Sarah Hamm-Alvarez, PhD

Microtubule-Based Transport in Lacrimal Gland Function NIH Sarah Hamm-Alvarez, PhD

The Pediatric Eye Disease Consortium: a Pooled Analysis of Individual-Participant Data from Population-based Studies NIH Xuejuan Jiang, PhD

Helicobacter Pylori Infection and Primary Open-angle Glaucoma among Mexican Americans: an Example of Microbiota-Gut-Brain Axis? USC Xuejuan Jiang, PhD

Long-term Outcomes and Genetic Basis of Early-onset Refractive Errors in Preschool Children USC Xuejuan Jiang, PhD

AGS (American Glaucoma Society) • CIRM (California Institute for Regenerative Medicine) • GSK (GlaxoSmithKline) NIH (National Institutes of Health) • NSF (National Science Foundation) • RPB (Research to Prevent Blindness)

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Bosco Tjan, PhD, professor of psychology at the USC Dornsife College of Letters, Arts and Sciences and co-director of USC Dana and David Dornsife’s Cognitive Neuroimaging Center, died tragically Dec. 2, 2016.

Tjan was a world-renowned expert in the field of vision loss research and was principal investigator in the study to discover how the brain reacts to blindness.

During a tribute service on USC University Park Campus, he was remembered as an insightful and generous colleague, an outstanding teacher, a prolific researcher and an exceptional collaborator.

He is survived by his wife and son.

RESEARCH

Figure 1: Cortical thickness (medial view of the cortices).

Figure 2: Cortical response (fMRI) to light (medial view of the cortices).

IN MEMORIAM BOSCO TJAN, PhD

EXPLORING THE BRAIN’S ROLE IN BLINDNESS By understanding how the brain responds to low vision and blindness, USC Roski Eye Institute researchers strive to understand in unprecedented detail, the structural and functional connections of the visual brain.

A $4 million, four-year study funded by the National Institutes of Health will build upon the brain mapping techniques developed for the Human Connectome Project. Our team of researchers will recruit more than 100 patients with macular degeneration, retinitis pigmentosa and various optic nerve disorders, in their efforts to study how individual brains adapt to visual disorders over time.

Deeper understanding of the visual brain holds great promise for future innovations. If differences in the central visual pathways behind the retina and optic nerve caused by eye disorders can be observed earlier, treatments to preserve vision can be developed sooner.

Collaborating on study are Hossein Ameri, MD, PhD, Amir Kashani, MD, PhD, Andrew Moshfeghi, MD, MBA, Vivek Patel, MD, and James Weiland, PhD.

The doctors worked with skill and earned my confidence, and now I can see clearly again.

Mark Sweeney ” “

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Fuchs Dystrophy and CataractsOCULAR HISTORYVision loss from Fuchs dystrophy and cataracts caused difficulty with driving and enjoying activities.

TREATMENTCombined Descemet’s Membrane Endothelial Keratoplasty (DMEK) and cataract surgery.

OUTCOMEComplete restoration of vision one month after each surgery.

A continuing blur in his right eye led Mark Sweeney to contact the USC Roski Eye Institute. Karen Morgan, MD, examined Mark and determined that he had Fuchs dystrophy, a swelling and clouding of the cornea. She began conservative treatment with eye drops, but then determined that a more invasive approach was needed. J. Martin Heur, MD, PhD, recommended combined DMEK and cataract surgery. The procedure was successful, and within one month the vision in Mark’s right eye not only was clear, but also corrected so he would not need glasses. His vision began blurring in his left eye, so Mark was excited and confident to have Heur repeat the procedure so he would have sharp vision in both eyes. Mark was delighted to get back to playing golf and seeing all the details at concerts at the Hollywood Bowl —without wearing glasses. “I can finally see clearly,” Mark says. “It’s truly amazing.”

Mark Sweeney

Now that his vision has been restored, Mark has returned to outdoor activities and and attending concerts with renewed excitement.

Image of the eye shows corneal swelling and cloudiness from Fuchs dystrophy.

Karen Morgan, MD, and J. Martin Heur, MD, PhD, worked together to restore and improve vision in both eyes for Mark.

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Sarah Hamm-Alvarez (center) is surrounded by her research team (from left to right) Zhen Meng, Srikanth Janga, Maria Edman and Christina Fu.

DETECTING DISEASE WITH TEARDROPS By discovering a biomarker in teardrops, Sarah Hamm-Alvarez, PhD, and her research team may advance treatment of Sjögren’s syndrome. The disease can have devastating effects as immune cells attack mucous membrane and fluid-secreting glands. It starts with dryness in the eyes and mouth, but eventually progresses to damage major organs. No single test exists to confirm Sjögren’s syndrome, so diagnosis can take years.

“Our discovery will help diagnose and treat Sjögren’s syndrome more effectively, particularly the dry-eye side effect of the disease,” said Hamm-Alvarez. The promise of a simple tear-based test has the potential to improve life for the four million people in the U.S. who have Sjögren’s syndrome. Nine out of 10 patients are women who would be protected from the dire consequences of the disease.

Sarah Hamm-Alvarez, PhD

“ Our discovery will help diagnose and treat Sjögren’s syndrome.”

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SEEING WITH THE BRAIN — WITHOUT EYESElectrical stimulation of the visual neurons could enable the blind to see again—without using their eyes. Cortical visual implants use the brain to “see” by capturing images on a video camera built into specialty eyeglasses and relaying them to electrodes implanted in the visual cortex. A major challenge is to precisely stimulate target nerve cells to provide accurate vision. Andrew Weitz, PhD, and his research team developed a novel imaging technique to map the patterns of cells activated by electrical stimulation. They then identified stimulus waveform shapes that enable precise stimulation of nerve cells in the retina for retinal implants. Now the team is developing waveforms for the visual cortex. By enabling precise control of patterns of neurons stimulated by cortical visual implants, they hope to restore accurate vision to people who have lost their eyes.

A cortical visual prosthesis consists of a miniature video camera built into the nosepiece of eyeglasses, signal-processing electronics carried in a pocket and arrays of microelectrodes implanted in the primary visual cortex. (Courtesy of Nature Publishing Group)

Andrew Weitz, PhD

“ A novel imaging technique is advancing cortical implants.”

RESEARCH

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REVERSING BLINDNESS WITH ULTRASOUND What if blindness could be reversed without surgery. Current methods for restoring sight from lost retinal receptor cells involve implanting devices to stimulate surviving retinal neurons.

Ultrasound waves are known to stimulate sight-giving retinal neurons. Using ultrasound to restore sight would require a specialized device to deliver ultrasound waves and the ability to map stimulation patterns. USC Roski Eye Institute researchers Mark Humayun, MD, PhD, and Qifa Zhou, PhD, are taking on these challenges.

Their goal is to develop ultrasonic single-element transducer/phased arrays for retinal stimulation, and design an optimal stimulation paradigm to produce controllable, consistent retinal responses with high spatiotemporal resolution — and provide in vivo validation.

Ultrasound therapies hold the promise of ending blindness on a scale far beyond current methods.

Mark Humayun, MD, PhD

Qifa Zhou, PhD

In this figure, 15-20 MHz convex phased array will not only provide a larger viewing angle and field of view than traditional linear arrays, but it will also be better at providing enough acoustic output and uniform acoustic field to generate dynamic vibration of retinal tissue over the traditional array. The phase array can be changed focus beam by electronic scanning. Meanwhile, high resolution OCT can detect cell structure changes of the retina with ultrasonic stimulation.

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Accelerating Progress through CollaborationThe USC Roski Eye Institute works closely with many individual researchers and organizations to advance vision science and clinical ophthalmology. We gratefully acknowledge colleagues for their efforts in 2016.

INDIVIDUALSINDIVIDUALSBioengineering InitiativeCOLLABORATOR ORGANIZATIONTheodore Berger, PhD USC (Biomedical Engineering)Robert Chow, MD, PhD USC (Zilkha Neurogenetic Institute)Scott E. Fraser, PhD USC (Biomedical Engineering)Malancha Gupta, PhD USC (Materials Science)Hossein Hashemi, PhD USC (Electrical Engineering)Laurent Itti, PhD USC (Computer Science)Gianluca Lazzi, PhD University of Utah, UTMark Liker, MD USC (Neurosurgery)Gerard Medioni, PhD USC (Computer Science)Ellis Meng, PhD USC (Biomedical Engineering)Alapakkam Sampath, PhD UCLA Brain Research InstituteKirk Shung, PhD USC (Biomedical Engineering)Dong Song, PhD USC (Biomedical Engineering)Armand Tanguay, PhD USC (Electrical Engineering)

Cross-Linking and Refractive Surgical OutcomesCOLLABORATOR ORGANIZATIONWilliam J. Dupps, MD, PhD USC (Biomedical Engineering)

Farhad Hafezi, MD, PhD The USC Roski Eye Institute and ELZA Institute, Switzerland

Marcony Santhiago, MD, PhD University of Sao Paulo, Brazil and Federal University of Rio de Janeiro

Giuliano Scarcelli, PhD University of Maryland Fischell School of Engineering, MD

Human Connectome ProjectCOLLABORATOR ORGANIZATIONJames T. Becker, PhD University of Pittsburgh, PAAdam L. Boxer, MD, PhD USCF Memory and Aging CenterKyle Chard, PhD University of Chicago, ILKristi Clark, PhD USC (Neurology)Eric Deutsch, PhD Institute for Systems Biology, WAIvo Dinov, PhD University of Michigan, MIJames Duncan, PhD Yale University, CTJerome Engel, MD UCLA David Geffen School of MedicineIan Foster, PhD University of Chicago, ILGiovanni Frisoni, MD IRCCS Fatebenefratelli, ItalyGustavo Glusman, PhD Institute for Systems Biology, WA

Dana Goldman, PhD USC (Schaeffer Center for Health Policy and Economics)

Gerig Guido, PhD University of Utah, UTSusan Hayflick, MD Oregon Health & Science University, OR

Scott Holland, PhD Cincinnati Children’s Research Foundation, OH

Leroy Hood, MD, PhD Institute for Systems Biology, WA

John Van Horn, PhD USC (Neurology)

Carl Kesselman, PhD USC (Industrial and Systems Engineering)

Richard Leahy, PhD USC (Electrical Engineering)Robert Scott Mackin, PhD UCSF School of MedicineGeoffrey T. Manley, MD, PhD UCSF School of MedicineTom Nichols, PhD University of Warwick, United KingdomYuko Y. Palesch, PhD Medical University of South Carolina, SCNathan Price, PhD Institute for Systems Biology, WABruce Rosen, MD, PhD Massachusetts General Hospital, MAHoward Rosen, MD USCF Memory and Aging Center

Seth Seabury, PhD USC (Schaeffer Center for Health Policy and Economics)

Yonggang Shi, PhD USC (Neurology)Olaf Sporns, PhD Indiana University, IN

Michael Weiner, MD Northern California Institute for Research & Education, CA

Wenle Zhao, PhD Medical University of South Carolina, SC

Imaging InitiativeCOLLABORATOR ORGANIZATIONAntonio Capone, MD Oakland University, MIZhongping Chen, PhD UCI Samueli School of Engineering, CAThomas Karnowski, PhD Oak Ridge National Labs, TNMichael Trese, MD Oakland University, MIGeorge Williams, MD Oakland University, MI

Mark Wong, PhD National Aeronautics and Space Administration, MD

Ocular EpidemiologyCOLLABORATOR ORGANIZATIONStanley Azen, PhD USC (Preventive Medicine)Xiaoyi Gao, PhD University of Illinois at Chicago, ILJames Gauderman, PhD USC (Preventive Medicine)Joanne Katz, ScD Johns Hopkins University, MDRonald Klein, MD, MPH University of Wisconsin-Madison, WIRoberta McKean-Cowdin, PhD USC (Preventive Medicine)Joan M. O’Brien, MD University of Pennsylvania, PAJeremy Rotter, PhD Los Angeles Biomedical Institute, CAKristina Tarczy-Hornoch, MD Seattle Children's Hospital, WATien Wong, MD, PhD National University of Singapore

Regenerative Medicine for Blinding Eye DiseasesCOLLABORATOR ORGANIZATIONLarry A. Couture, PhD City of Hope, CA

Dennis Clegg, PhD UCSB Center for Stem Cell Biology and Engineering

Lincoln V. Johnson, PhD UCSB Center for the Study of Macular Degeneration

Population HealthCOLLABORATOR ORGANIZATION

Dana Goldman, PhD USC (School of Pharmacy), USC (Sol Price School of Public Policy)

Anupam Jena, MD, PhD Harvard University, MAGeoffrey Manley, MD, PhD UCSF School of Medicine

Mike Menchine, MD USC (Department of Emergency Medicine)

Sjögren’s SyndromeCOLLABORATOR ORGANIZATIONDaniel Arkfeld, MD USC (Department of Medicine)Stratos Christianakis, MD USC (Department of Medicine)Stan Louie, PhD USC (School of Pharmacy)Curtis Okamoto, PhD USC (School of Pharmacy)J. Andrew MacKay, PhD USC (School of Pharmacy)

Wendy Mack, PhD USC (Department of Preventive Medicine)

Kathleen Rodgers, PhD USC (School of Pharmacy)William Stohl, MD, PhD USC (Department of Medicine)Driss Zoukhri, PhD Tufts University School of Dentistry, MA

RESEARCH

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Choroidal MelanomaOCULAR HISTORYDiagnosed with a choroidal melanoma after continuous retinal issues, detachments and bleeding.

TREATMENTPatient decided to undergo plaque brachytherapy (radiation implant) to save the eye, regardless of impact on vision.

OUTCOMECancer controlled. Tumor regressing. No observable metastatic disease. Left eye preserved with vision loss.

Losing an eye to cancer was a real possibility for Arnold Michels. After a long and complicated history of retinal issues, detachments and bleeding in his left eye, he finally learned why: he had choroidal melanoma — eye cancer.

As an avid outdoorsman and photographer, Arnold first thought that he would have to abandon his passion for hiking and introducing children to nature as a volunteer. Without vision, he could not navigate the terrain.

After five difficult surgeries on his eye, Arnold came to the USC Roski Eye Institute with a specific goal. Already blind in his left eye, he wanted to avoid its removal. To achieve this goal, surgeons performed a long, complex surgery in which they implanted a device that would precisely target the tumor with radiation.

The procedure was a success. Arnold’s cancer is under control, the tumor is shrinking and he has no sign of metastatic disease. Best of all, he is delighted to still have his left eye. “They went above and beyond all my expectations,” Arnold says.

Arnold Michels

Retinal photograph of eye with a malignant choroidal melanoma.

Arnold enjoys playing with his grandchildren, Olivia and Colin.

Choroidal melanoma in the left eye after trans-retinal prognostic biopsy.

Jesse Berry, MD, performed the surgery that saved Arnold’s left eye from cancer.

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They went above and beyond all my expectations.Arnold Michels ” “

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SERVING THE UNDERSERVED AT LAC+USCThe USC Roski Eye Institute is the exclusive provider of vision care at the LAC+USC Medical Center, the hub of a Los Angeles County health system that serves 10 million people. This presents multiple opportunities to provide a wide array of complex, clinical care that profoundly enhances people’s lives.

USC Roski Eye Institute residents, shown with ophthalmologist Jesse Berry, MD, follow patients longitudinally throughout their residencies at LAC+USC for an exceptional clinical and personal experience.

The 600-bed Los Angeles County + USC Medical Center is one of the largest public hospitals in the country and one of the premier academic teaching hospitals in the nation.

LAC+USC Ophthalmology

200 Patients per day

10 Surgeries per day

5 Ophthalmology subspecialties

Recycle Vision Recycle Vision, started by USC’s Jesse Berry, MD, collects used eyeglasses and logs prescriptions. They then match prescriptions and give eyeglasses to patients who otherwise might not afford them.

55% Eyeglass Prescriptions Not Filled

67% Patients Concerned about Cost

300+ Pairs of Used Eyeglasses Provided

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Vulnerable patients will benefit from greater access to eye care as new studies are launched and new healthcare policies are adopted.

IMPROVING ACCESS, QUALITY AND EFFICIENCY The USC Roski Eye Institute is at the heart of USC’s latest efforts to tackle the challenges of healthcare system reform.

The newly established Keck-Schaeffer Initiative for Population Health Policy is led by Seth Seabury, PhD, associate professor in the USC Department of Ophthalmology and associate professor of research in the Leonard D. Schaeffer Center for Health Policy and Economics. Its mission is to identify evidence-based policies that improve access to care for underserved populations and increase the value of the services provided.

This collaboration between the Keck School of Medicine of USC and the USC Schaeffer Center will be the catalyst for new research and educational studies for improving population health and healthcare delivery.

Seth Seabury, PhD

“ We will strive to use cutting-edge research to help improve the health of vulnerable populations.”

RESEARCH

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INSIGHT

Preserving SightThe USC Roski Eye Institute champions preventive care, engages in partnerships and inspires philanthropy in our mission to eliminate visual impairment and blindness.

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Chandrasekhar Sankurathri, MD, visiting professor of ophthalmology, has dedicated his life to saving the vision of people who would otherwise go blind.

In 1989, he established the nonprofit Sankurathi Foundation as a memorial to his wife, son and daughter who were killed in an Air India terrorist bombing on July 23, 1985. The mission was to “empower the poor through better education, eye care and timely help to the needy.” His mission expanded in 1993 with the opening of the Srikiran Institute of Ophthalmology, named after his son. The eye hospital provides accessible and affordable services to all “irrespective of race, religion, caste, age, sex and other socioeconomic factors.”

From conducting preventive screenings to providing complex procedures, often without charge, the hospital is improving the lives of people in rural India.

IMPROVING

Life IN RURAL

India Clockwise from top: Srikiran Institute of Ophthalmology; Chandrasekhar Sankurathri, MD; cataract patients on post-op day one; 3rd-year resident Philip Storey, MD, MPH, examines a patient; Storey and USC Assistant Professor Jesse Berry, MD, during a rotation in India.

PRESERVING VISION

In its 23 years, the nonprofit Srikiran Institute of Ophthalmology has achieved an impressive record of service:

2,360 screening camps for adults

1,073 screening camps for children

2,170,855 outpatient visits

208,577 surgeries

PRESERVING SIGHT

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SHEDDING LIGHT TO PREVENT BLINDNESSNew National Eye Institute studies led by Rohit Varma, MD, MPH, suggest that vision screening for refractive error and early eye disease may reduce or prevent a high proportion of individuals from experiencing unnecessary vision loss and blindness. These findings will guide clinical care and health policy designed to protect and preserve the vision of all Americans.

EYE HEALTH IN

AMERICA

2050 FORECAST

VISUAL IMPAIRMENT AND BLINDNESS IN THE UNITED STATES, 2015-2050

3.22 MILLION

6.95 MILLION

2015 2050

VISUAL IMPAIRMENT

AGE 40+

16.4 MILLION

8.2 MILLION

2015 2050

VISUAL IMPAIRMENT & BLINDNESS

AGE 40+ FROM UNCORRECTED VISION

290K

529K

VISUAL IMPAIRMENT BLINDNESS

2.01 MILLION

1.02 MILLION

2015 2050

BLINDNESS AGE 40+

VISUAL IMPAIRMENT

1.38 MILLION

3.02 MILLION

1.84 MILLION

3.94 MILLION

FEMALE MALE

2015 2050

VISUAL IMPAIRMENT AND BLINDNESS BY GENDER, 2015-2050

2015 2050

BLINDNESS

490K 960K

520K 1.05 MILLION

BURDEN OF BLINDNESS AND VISUAL IMPAIRMENT AMONG WOMEN IS HIGHER AND EXPECTED TO INCREASE *

THE NUMBER OF CASES IS EXPECTED TO DOUBLE BY 2050 *

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THE LARGEST BURDEN WILL BE AMONG NON-HISPANIC WHITES AND IS EXPECTED TO INCREASE AMONG OTHER GROUPS *

PRESERVING SIGHT

CHINESE AMERICAN EYE STUDY KEY FINDINGS

• Greater prevalence of neovascular (wet) age-related macular degeneration

• Three times higher prevalence of visual impairment among those with type II diabetes than those without diabetes

LOS ANGELES LATINO EYE STUDY KEY FINDINGS

• Significantly lower quality of life for those with severe age-related macular degeneration in one or both eyes

• Less access and utilization of health care may contribute to quality of life decline

TWO STUDIES ON ADDITIONAL POPULATIONS PROVIDE MAJOR INSIGHTS The largest U.S. epidemiological studies ever conducted on Chinese Americans and Latinos were published in 2016 by the USC Roski Eye Institute.

VISUAL IMPAIRMENT AND BLINDNESS BY RACIAL/ETHNIC GROUPS, 2015-2050

VISUAL IMPAIRMENT 2015 2050

NON-HISPANIC WHITE 2.3 MILLION

3.9 MILLION

AFRICAN AMERICAN 500K 1.1 MILLION

LATINO 300K 1.4 MILLION

ASIAN AND OTHER 100K 500K

BLINDNESS 2015 2050

NON - HISPANIC WHITE 700K 1.1 MILLION

AFRICAN AMERICAN 200K 500K

LATINO 100K 400K

ASIAN AND OTHER 20K 50K

* For complete findings please refer to: Visual Impairment and Blindness in Adults in the United States: Demographic and Geographic Variations from 2015 to 2050. JAMA Ophthalmol. PMID: 27197072.

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GIVING GENEROUSLY TOADVANCE VISION CARE

Gayle and Edward Roski took a bold step in 2016 to improve vision and end blindness. They made a landmark $25 million gift to endow and name the USC Gayle and Edward Roski Eye Institute at Keck Medicine of USC.

Their generosity was inspired by personal experiences and deep concern for others. After Gayle Garner Roski, a plein-air watercolorist, received cataract treatment at the USC Eye Institute, her ability to see color and light values improved dramatically. To help others fully enjoy the gift of sight, they decided to make a major gift.

Their exceptional support will enable the USC Roski Eye Institute to continue its powerful influence on vision care, research and education around the world.

Edward and Gayle Roski accelerated the advancement of clinical ophthalmology and vision science through their landmark gift.

The vibrant paintings by Gayle Garner Roski, an accomplished watercolorist, have been exhibited in museums and galleries from California to Scotland.

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INSIGHT

Clinical EducationThe USC Roski Eye Institute equips and emboldens generations of clinician-scientists who revolutionize the diagnosis and treatment of eye conditions and diseases.

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ADVANCING OPHTHALMIC TECHNICIAN EDUCATION The USC Roski Eye Institute established a new Ophthalmic Technician Education Program (OTEP), joining only 14 centers nationwide offering this specialized training.

OTEP is a certificate program that integrates core academic knowledge with clinical and occupational skill mastery. It includes classroom and clinical experiences that prepare graduates to assist ophthalmologists in the prevention, detection and treatment of vision impairments in private practice offices, hospitals and community-based clinics. OTEP students have clinical rotations at the USC Roski Eye Institute, LAC+USC Medical Center and Children’s Hospital Los Angeles.

The U.S. Department of Labor projects a 21 percent increase in ophthalmic medical positions by 2021. The new program is designed to help meet this urgent need.

Joseph Cocozza, PhD, co-directs the Ophthalmic Technician Education Program.

Joseph Cocozza, assistant professor of research, instructs students in the new Ophthalmic Technician Education Program.

“ OTEP joins only 14 centers nationwide offering this specialized training.”

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CLINICAL EDUCATION

SHARPENING SKILLS FOR OCULOFACIAL SURGEONS WORLDWIDE

Sandy Zhang-Nunes, MD, organized the oculofacial surgical skills course with USC Roski Eye Institute staff.

Michael Burnstine, MD Director of the Oculofacial plastics fellowship program.

Participants from all over the world came together to share valuable skills.

The USC oculofacial surgical skills course brought together renowned faculty, fellows, and residents in oculoplastics, ophthalmology, ENT, and plastic surgery to learn from each other. American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) fellows from around the United States, as well as visiting scholars from around the world participated. After brief lectures, expert faculty rotated between fully equipped surgical stations that included surgical oculoplastic instruments, an endoscope, a drill, ultrasonic aspirator, plating material and a fresh cadaver head. Attendees learned new approaches and practiced valuable skills that will improve patient care.

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The PROSE procedure was a game changer. My eyes are no longer miserable all the time.

Jeremy Falk ” “

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Stevens-Johnson SyndromeOCULAR HISTORYDeveloped Stevens-Johnson Syndrome after taking Bactrim to treat an infection, resulting in eye pain, dryness, light sensitivity and irritation.

TREATMENTReceived custom-designed PROSE (prosthetic replacement of the ocular surface ecosystem) scleral devices.

OUTCOMEImproved comfort, vision and quality of life.

Extreme light sensitivity and sore, bloodshot eyes made life difficult for Jeremy Falk, an independent businessman, distance runner and self-proclaimed “power nerd.” A terrible reaction to an antibiotic left him with chronic, severe dry eyes. After years of seeking relief, he finally found it at the USC Roski Eye Institute.

To compensate for the lack of tears, Gloria Chiu, OD, FAAO, FSLS, initiated Boston Sight® PROSE (prosthetic replacement of the ocular system) treatment, available at only 12 sites nationwide. Now Jeremy’s eyes are protected and kept moist by a set of made-to-specification removable scleral devices that cover the entire outer surface of his eyes.

Initially, Jeremy was anxious about placing the lenses on his eyes. After some training, coaching and practice, he mastered the process. “Dr. Chiu was patient, gentle, professional and no nonsense,” Jeremy says. “She changed my life.”

Jeremy’s eyes are much better, and life has returned to normal. Armed with his “rock ‘n roll eyeball kit,” he faces the world with greater confidence and a brighter outlook.

Jeremy Falk

Jeremy’s active lifestyle includes cycling and distance running.

The gas-permeable PROSE device creates a smooth optical surface above the cornea and bathes the ocular surface with a reservoir of sterile saline. (Image courtesy of Boston Sight®.)

With training, patients eventually master application and use of the PROSE device.

Gloria Chiu, OD, FAAO, FSLS, prescribed and fitted the PROSE lenses that provide relief for Jeremy’s eye condition.

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A FORMER USC RESIDENT RETURNS TO USC ROSKI EYE INSTITUTE WITH INSIGHTS FOR SUCCESS.

On Career Choice

“ I took a biochemistry class at Francisco Bravo Medical Magnet High School, taught by USC’s Dr. Cocozza, that focused on the chemistry behind ophthalmology. I knew from that point that ophthalmology was what I wanted to do.”

On Residency Training

“ My advice is to find a program that is best suited to your individual needs. If you’re looking for strong clinical and surgical training, and to be an innovative leader, then USC is the place for you.”

“ USC has one of the most challenging ophthalmology residency programs in the country, hands down. I left the program so confident, so prepared to take on any challenge that came my way.”

On USC Faculty

“ A very strong teaching component with LAC+USC Medical Center allows faculty to play a big role in the training and mentorship of residents and fellows.”

SHARING ADVICE WITH FUTURE LEADERS

Sahar Bedrood, MD, PhD

Assistant Professor of Clinical Ophthalmology

MEDICAL SCHOOL| MD/PHD Keck School of Medicine of USC

OPHTHALMOLOGY RESIDENCY LAC+USC Medical Center

GLAUCOMA FELLOWSHIPThe Johns Hopkins Wilmer Eye Institute

RESEARCH• Structural characteristics of the optic nerve

lamina cribrosa

• Glaucoma disruption of patients’ daily functional ability

PROFESSIONAL ORGANIZATIONS• American Glaucoma Society • American Society of Cataract and Refractive Surgery • Los Angeles Society of Ophthalmology • Society of Heed Fellows

AWARDS

• Society of Heed Fellows Fellowship Award

• National Eye Institute ARVO Award

• P.E.O. Scholar Award

• Order of the Arete

• Remarkable Women of USC Award

41ST Anniversary Symposium Distinguished Ophthalmologists

Nisa Acharya, MD Director, Uveitis Service and Uveitis Fellowship, F.I. Proctor Foundation and Professor of Ophthalmology, University of California, San Francisco

Pravin U. Dugel, MD Clinical Professor, USC Roski Eye Institute, Keck School of Medicine of USC, Managing Partner, Retinal Consultants of Arizona and Founding Member, Spectra Eye Institute

Jonathan M. Holmes, MD Joseph E. and Rose Marie Green Professor of Visual Sciences and Professor of Ophthalmology and Former Chair, Department of Ophthalmology, College of Medicine, Mayo Clinic

Mark S. Humayun, MD, PhD Cornelius J. Pings Chair in Biomedical Sciences, Professor of Ophthalmology, Biomedical Engineering and Cell and Neurobiology, Director of the USC Institute for Biomedical Therapeutics and Co-Director of the USC Roski Eye Institute, Keck School of Medicine of USC

Sean Ianchulev, MD, MPH Chief Medical Officer and Vice President, Medical Affairs and Business Development, Transcend Medical

Guy G. Massry, MD Clinical Professor of Ophthalmology, Keck School of Medicine of USC

Neil R. Miller, MD Frank B. Walsh Professor of Neuro-Ophthalmology and Professor of Ophthalmology, Neurology and Neurosurgery, Johns Hopkins Medical Institutions

J. Bradley Randleman, MD Professor of Ophthalmology and Director of Cornea, External Disease and Refractive Surgery, USC Roski Eye Institute, Keck School of Medicine of USC

J. Timothy Stout, MD, PhD, MBA Director, Cullen Eye Institute and Chair, Department of Ophthalmology, Baylor College of Medicine

Young Hee Yoon, MD, PhD Professor of Ophthalmology, Asan Medical Center, University of Ulsan, South Korea

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CELEBRATING ADVANCEMENTS IN OPHTHALMOLOGYNearly 400 ophthalmologists and optometrists attended the USC Roski Eye Institute 41st Anniversary Symposium at the Huntington Library in Pasadena. The event’s distinguished speakers provided presentations on every subspecialty of ophthalmology.

Rohit Varma, MD, MPH, left, presented Neil R. Miller, MD, the Frank B. Walsh Professor of Neuro-Ophthalmology and professor of ophthalmology, neurology, and neurosurgery, Johns Hopkins Medical Institutions, with the USC Roski Eye Institute Laureate Award for 2016.

Preeminent vision experts shared their work with a capacity crowd.

USC Roski Eye Institute faculty members at the 41ST Anniversary Symposium.

CLINICAL EDUCATION

NEW FULL-TIME FACULTY FOR 2016

PREPARING AND INSPIRING THE NEXT LEADERS

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Name Title Specialty

Sahar Bedrood, MD, PhD Assistant Professor of Clinical Ophthalmology Glaucoma

Kent Nguyen, OD, FAAO Assistant Professor of Clinical Ophthalmology Comprehensive Eye Care in Primary Care, Ocular Disease, and Contact Lenses

J. Bradley Randleman, MD Professor of Clinical Ophthalmology Corneal and External Diseases and Corneal Cross-Linking

Seth Seabury, PhD Associate Professor of Research Ophthalmology Ophthalmology Health Policy and Economics

Mahnaz Shahidi, PhD Professor of Ophthalmology Retinal Imaging

Lan Yue, PhD Assistant Professor of Research Ophthalmology Retinal Prosthesis

Qifa Zhou, PhD Professor of Ophthalmology, Biomedical Engineering

Biomedical Engineering Ophthalmic Elastography, Ultrasonic Retinal and Brain Stimulation

The USC Roski Eye Institute residents and fellow train in four diverse and highly acute clinical and surgical settings: the USC Roski Eye Institute, Children’s Hospital Los Angeles, Los Angeles County Hospital (LAC+USC Medical Center) and Veterans Administration Downtown Los Angeles Medical Center.

NEW OPPORTUNITIES FOR 2016Each year, positions open for six new residents and eight new fellows. Hundreds of outstanding candidates apply to train at the USC Department of Ophthalmology.

VOLUNTARY RESIDENT ROTATION IN INDIA Residents will complete two-week, on-site comprehensive and subspecialty clinics at the Srikiran Institute of Ophthalmology in rural Andhra Pradesh, India.

NEW FELLOWSHIP IN EYE PATHOLOGY Fellows have extraordinary learning opportunities at USC’s ophthalmic molecular and immuno-pathology laboratory, one of the few in the United States.

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HISTORY• Hispanic female, age 66, presents to

the emergency department with worsening blurred vision over several weeks and a one-year history of intermittent binocular diplopia, pulsating left-ear pain and tinnitus.

• PMH: HTN, DM Type 2, Dyslipidemia Hyperthyroidism.

• ROS negative for headaches, nausea or sudden loss of vision.

EXAM FINDINGS• BCVA 20/20 OD, 20/30 OS, IOP WNL, no

RAPD, Ishihara color plates normal OU.

• Anterior segment exam on slit lamp only notable for 2+ NSC of the lens OU.

• Dilated fundus exam: normal appearing optic nerves with CDR 0.4 without evidence of swelling or atrophy.

DIFFERENTIAL DIAGNOSIS• Bilaterally swollen optic nerves with near

normal function. Elevated intercranial pressure (ICP) would suggest obstruction or abnormality. Normal ICP would suggest diabetic papillopathy, optic perineuritis or hypertensive papillopathy.

ADDITIONAL INVESTIGATIONS • MRI brain with and without contrast

was obtained to better characterize the etiology of the elevated ICP. (See Figures 1 and 2.)

DIAGNOSIS• Paraganglioma causing compression

of the left internal jugular vein.

• Jugular venous obstruction resulted in impaired CSF absorption, leading to elevated ICP.

• Sufficiently compartmentalized CSF pressure may allow some cases of elevated ICP to present without papilledema.

TREATMENT• Since malignant behavior is only seen in

4% of jugulotympanic paragangliomas, treatment options include observation, surgical resection with preoperative embolization, radiotherapy and radiosurgery.

• Patient was seen eight weeks after initial visit. Stable nature of the symptoms led us to monitor her with dilated fundus exams and Humphrey visual fields at subsequent visits. She is also being followed by neurology and ENT services as an outpatient for possible surgical intervention if symptoms worsen.

THIS CASE ILLUSTRATES THE IMPORTANCE OF THE CEREBRAL VENOUS SYSTEM IN THE REGULATION OF CSF PRESSURE AND NEUROIMAGING FEATURES THAT CAN SUPPORT A SUSPICION OF ELEVATED ICP.

Vivek Patel, MD, residency program director (left), and first-year resident Debarshi Mustafi, worked together on the “Double Trouble” case.

ROUNDSGRAND

INSPIRING CLINICAL EXCELLENCE THROUGH

THE USC ROSKI EYE INSTITUTE PRESENTS RESIDENTS WITH COMPLEX CLINICAL CHALLENGES, AS DEMONSTRATED BY THE CASE “DOUBLE TROUBLE” SUMMARIZED BELOW.

Figure 1. Axial (left) and sagittal (right) cuts demonstrate an absence of flattening of the back of the globe or tortuosity of the optic nerve that can be seen with elevated ICP.

Figure 2. MRI brain post-contrast, sequential axial T1 images reveal an avidly enhancing mass (blue arrow) measuring 23 x 15 x 24 mm (TV x AP x CC) within and expanding the left jugular foramen, and enveloping the left internal jugular vein (red arrow).

CLINICAL EDUCATION

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Jiun L. Do, MD, PhD

Third Year

Second Year

First Year

Stavros Moysidis, MD Billy Pan, MD Co-Chief Resident

Kelly Rue, MD Grace Shih, MD Philip Storey, MD, MPH

Co-Chief Resident

Walid F. Abdallah, MD, PhD

On-Tat Lee, MD Natasha Naik, MD Ananth Sastry, MD Brandon Wong, MD Arman Zaman, MD

Christine Greer, MD, MS

Arezu Haghighi, MD Ramon Lee, MD Debarshi Mustafi, MD, PhD

Luv Patel, MD Nadim Rayess, MD

Fellows and Clinical Instructors

The USC Roski Eye Institute offers clinical fellowship training in six subspecialty areas, including cornea and external disease, glaucoma, neuro-ophthalmology, ophthalmic plastic surgery, retina and uveitis.

Informal research fellowships are also awarded by each service and laboratory independently. The USC Roski Eye Institute attracts promising academic ophthalmologists from around the world who spend one or two years participating in research programs. Many return to their home countries where they assume positions of national or international leadership.

Brian Do, MDVitreoretinal

Kimberly Gokoffski, MD, PhD

Neuro-Ophthalmology

Humair Khan, MDCornea

Jessica Maslin, MDGlaucoma

Julie Kwon, MDMedical Retina

Nishant Soni, MD Cornea

Helen Merritt, MDOculo-Facial

Plastics

Julia Nemiroff, MDMedical Retina

Jeffrey Tan, MD Vitreoretinal

Brian Toy, MDVitreoretinal

Residents Six exceptional residents are recruited each year from hundreds of applicants.

USC ROSKI EYE INSTITUTE RESIDENTS AND FELLOWS 2016-17

PROGRAM LEADERSHIP

Rohit Varma, MD, MPHDirector, USC Roski Eye Institute

Vivek Patel, MDResidency Program Director

Jesse Berry, MDAssociate Residency Program Director

Malvin Anders, MD Chief of Ophthalmology, LAC+USC Medical Center

from top left to right

usceye.org

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Seth Seabury, PhD Associate Professor

John Whalen, PhDAssistant Professor

Lan Yue, PhD Assistant Professor

Sandy Zhang-Nunes, MDAssistant Professor

Qifa Zhou, PhD Professor

Hossein Ameri, MD, PhD

Assistant Professor

Jesse Berry, MDAssistant Professor

Sahar Bedrood, MD, PhD

Assistant Professor

Mark Borchert, MDAssociate Professor

Angela Buffenn, MD, MPH

Assistant Professor

Gloria Chiu, OD, FAAO, FSLS

Assistant Professor

David Cobrinik, MD, PhD

Associate Professor

Farzana Choudhury, MBBS, MPH, PhD

Assistant Professor

Joseph Cocozza, PhD Assistant Professor

Cheryl Craft, PhDProfessor

Charles Flowers Jr., MDAssociate Professor

Henry Fong, PhDAssociate Professor

Sarah Hamm-Alvarez, PhD

Professor

J. Martin Heur, MD, PhD

Associate Professor

Mark Humayun, MD, PhDProfessor

Veronica Isozaki, OD, FAAO

Assistant Professor

Shinwu Jeong, PhDAssistant Professor

Xuejuan Jiang, PhDAssistant Professor

Amir Kashani, MD, PhD

Assistant Professor

Jonathan Kim, MDAssociate Professor

Linda Lam, MD, MBAAssociate Professor

Carlos Lastra Gonzalez, MD Clinical Research

Instructor

Thomas Lee, MDAssociate Professor

Debbie Mitra, PhDAssistant Professor

Karen Morgan, MD Clinical Professor

Andrew Moshfeghi, MD, MBA

Associate Professor

Arlanna Moshfeghi, MD, MPH

Assistant Professor

A. Linn Murphree, MDProfessor

Sudha Nallasamy, MDAssistant Professor

Arthur Toga, PhDProvost Professor

Lernik Torossian OD, FAAO

Assistant Professor

Rohit Varma, MD, MPH Professor

Jonathan Song, MDAssociate Professor

Biju Thomas, PhDAssistant Professor

Paul Thompson, PhD Professor

J. Bradley Randleman, MD

Professor

Narsing Rao, MDProfessor

David Richardson, MDAdjunct Assistant

Professor

Bibiana Reiser, MD, MS

Assistant Professor

Mahnaz Shahidi, PhDProfessor

Vivek Patel, MDAssociate Professor

Andrew Weitz, PhDAssistant Professor

James Weiland, PhD Professor

Carmen Puliafito, MD, MBAProfessor

Kent Nguyen, OD, FAAO Assistant Professor

Damien Rodger, MD, PhD

Assistant Professor

Grace Richter, MD, MPH

Assistant Professor

Alena Reznik, MDAssistant Professor

USC ROSKI EYE INSTITUTE FACULTY

Tali Kolin, MD Adjunct Associate

Professor

Michael Burnstine, MD

Clinical Professor

Steven Dresner, MD Clinical Professor

CLINICAL EDUCATION

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Soma Agarwal, MDJohn Affeldt, MD Malvin Anders, MDRajat Agrawal, MD, MS

Selwa Al-Hazzaa, MD

Richard Apt, MD Joseph Boban, MDGregory Bearman, PhD

David Boyer, MDSwaraj Bose, MD Gerald Chader, PhD

Grace Chang, MD, PhD

Gerald Bowns, MD Brian Brown, MD Michael Colvard, MD

Lawrence Chong, MD

Gregg Feinerman, MD

Lauren Daskivich, MD

Kenneth Diddie, MD

Pravin Dugel, MD David Fuerst, MD David Goldenberg, MD

Wolfgang Fink, PhD

Sam Goldberger, MD

Farhad Hafezi, MD, PhD

Ronald Green, MD Houman Hemmati, MD, PhD

Leif Hertzog, MDLars Hertzog, MD Alan Horsager, PhD Lynn Huang, MD, MPH

John Hwang, MD

Phillip Phuc Le, MD, PhD

James Lambert, PhD

Sean Ianchulev, MD, MPH

Karim Jamal, MD Michael Koss, MDJoseph Kim, MD Derek Kunimoto, MD

Grant Lee, MD

Raghu Murthy, MDDouglas McCreery, PhD

Garlan Lo, MD Jonathan Macy, MD Alan Mandelberg, MD

Alfred Marrone, MD Guy Massry, MD William May, MD

USC ROSKI EYE INSTITUTE VOLUNTEER FACULTY

usceye.org

494949

Dante Pieramici, MD

Paul Prendiville, MD

Warren Reingold, MD

Kami Parsa, MD

Christopher Zoumalan, MD

Lee Wan, MD Kenneth Wright, MD

David Yu, MDErik Tu, MD Paul Urrea, MD, MPH

Artin Petrossians, PhD

Arvind Saini, MD

Donald Serafano, MD

John Shammas, MD

Holly Spanggord, MD

Warren Stout, MDMarc Shomer, MD, PhD

Donald Schwartz, MD, MPA

Steve Schallhorn, MD

David Samimi, MD

James Salz, MD

USC ROSKI EYE INSTITUTE VOLUNTEER FACULTY

Harold Reaves, MD

CLINICAL EDUCATION

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1. Abdallah WF, Louie SG, Zhang Y, Rodgers KE, Sivok E, G Sd, Humayun MS. Norleu3a(1-7) Accelerates Clear Corneal Full Thickness Wound Healing. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2187-94.

2. Adam MK, Rayess N, Rahimy E, Maguire JI, Hsu J. Radial Versus Raster Spectral-Domain Optical Coherence Tomography Scan Patterns for Detection of Macular Fluid in Neovascular Age-Related Macular Degeneration. Br J Ophthalmol. 2016 Apr;100(4):491-4.

3. Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Renteria ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivieres S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser A, Bernard M, Bis JC, Blanken LM, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chauhan G, Chen Q, Ching CR, Cuellar-Partida G, Braber AD, Doan NT, Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL, Gottesman RF, Greven CU, Grimm O, Griswold ME, Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liao J, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand A, Matarin M, Mather KA, Mattheisen M, Mazoyer B, McKay DR, McWhirter R, Milaneschi Y, Mirza-Schreiber N, Muetzel RL, Maniega SM, Nho K, Nugent AC, Loohuis LM, Oosterlaan J, Papmeyer M, Pappa I, Pirpamer L, Pudas S, Putz B, Rajan KB, Ramasamy A, Richards JS, Risacher SL, Roiz-Santianez R, Rommelse N, Rose EJ, Royle NA, Rundek T, Samann PG, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Thomson R, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Vaidya D, Van der Grond J, Van der Meer D, Van Donkelaar

MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Woldehawariat G, Wolf C, Wolfers T, Xu B, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Aggarwal NT, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Chen C, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Geus EJ, De Jager PL, de Zubicaray GI, Delanty N, Depondt C, DeStefano AL, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Erk S, Espeseth T, Evans DA, Fedko IO, Fernandez G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Goring HH, Grabe HJ, Green RC, Gruber O, Gudnason V, Guelfi S, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Pol HE, Ikeda M, Ikram MK, Jr CR, Jenkinson M, Johnson R, Jonsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaitre H, Liu X, Longo DL, Jr WT, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon KL, McMahon FJ, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Muhleisen TW, Muller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nothen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt

R, Schofield PR, Sigurdsson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Srikanth V, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Tiemeier H, Toga AW, Traynor BJ, Troncoso J, Turner JA, Tzourio C, Uitterlinden AG, Hernandez MC, Van der Brug M, Van der Lugt A, Van der Wee NJ, Van Duijn CM, Van Haren NE, Van TED, Van Tol MJ, Vardarajan BN, Veltman DJ, Vernooij MW, Volzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke HR, Zonderman AB, Deary IJ, DeCarli C, Schmidt H, Martin NG, De Craen AJ, Wright MJ, Launer LJ, Schumann G, Fornage M, Franke B, Debette S, Medland SE, Ikram MA, Thompson PM. Novel Genetic Loci Underlying Human Intracranial Volume Identified through Genome-Wide Association. Nat Neurosci. 2016 Dec;19(12):1569-82.

4. Al Shamrani M, Al Hati K, Alkatan H, Alharby M, Jastaneiah S, Song J, Edward DP. Pathological and Immunohistochemical Alterations of the Cornea in Congenital Corneal Opacification Secondary to Primary Congenital Glaucoma and Peters Anomaly. Cornea. 2016 Feb;35(2):226-33.

5. Albini TA, Puliafito CA. 8 Questions with Dr. Puliafito. Interview with Thomas A. Albini, Md. Ophthalmic Surg Lasers Imaging Retina. 2016 Apr 1;47(4):390-2.

6. Albreiki D, Al Belushi F, Patel V, Farmer J. When a Temporal Artery Biopsy Reveals a Diagnosis Other Than Temporal Arteritis: Eosinophilic Granulomatosis with Polyangiitis. Can J Ophthalmol. 2016 Jun;51(3):e108-9.

7. Alhusaini S, Whelan CD, Sisodiya SM, Thompson PM. Quantitative Magnetic Resonance Imaging Traits as Endophenotypes for Genetic Mapping in Epilepsy. Neuroimage Clin. 2016;12:526-34.

INSIGHT

2016 Faculty PublicationsFaculty members at USC Roski Eye Institute discover and disseminate vital information that improves lives by contributing to the advancement of ophthalmology and vision science.

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8. Ang M, Vasconcelos-Santos DV, Sharma K, Accorinti M, Sharma A, Gupta A, Rao NA, Chee SP. Diagnosis of Ocular Tuberculosis. Ocul Immunol Inflamm. 2016 Jul 5:1-9.

9. Ardestani A, Shen W, Darvas F, Toga AW, Fuster JM. Modulation of Frontoparietal Neurovascular Dynamics in Working Memory. J Cogn Neurosci. 2016 Mar;28(3):379-401.

10. Ashish N, Bhatt P, Toga AW. Global Data Sharing in Alzheimer Disease Research. Alzheimer Dis Assoc Disord. 2016 Apr-Jun;30(2):160-8.

11. Ashish N, Dewan P, Toga AW. The Gaain Entity Mapper: An Active-Learning System for Medical Data Mapping. Front Neuroinform. 2015;9:30.

12. Becker M, Guadalupe T, Franke B, Hibar DP, Renteria ME, Stein JL, Thompson PM, Francks C, Vernes SC, Fisher SE. Early Developmental Gene Enhancers Affect Subcortical Volumes in the Adult Human Brain. Hum Brain Mapp. 2016 May;37(5):1788-800.

13. Berry JL, Cobrinik D, Kim JW. Detection and Intraretinal Localization of an ‘Invisible’ Retinoblastoma Using Optical Coherence Tomography. Ocul Oncol Pathol. 2016 Apr;2(3):148-52.

14. Berry JL, Shih G, Moysidis SN, Jubran R, Wong K, Lee TC, Murphree AL, Kim JW. Patterns of Subretinal Fluid Resolution in Group D Eyes Treated with Chemoreduction: Experience from the Children’s Hospital Los Angeles/University of Southern California. Ophthalmic Genet. 2016 Mar 2:1-4.

15. Binder NR, Kruglyakova J, Borchert MS. Strabismus in Patients with Cortical Visual Impairment: Outcomes of Surgery and Observations of Spontaneous Resolution. J aapos. 2016 Apr;20(2):121-5.

16. Blokland GA, Wallace AK, Hansell NK, Thompson PM, Hickie IB, Montgomery GW, Martin NG, McMahon KL, de Zubicaray GI, Wright MJ. Genome-Wide Association Study of Working Memory Brain Activation. Int J Psychophysiol. Epub 2016 Sep 23.

17. Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Gimenez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martinez-Zalacain I, Mataix-Cols D, Menchon JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson PM, Stein DJ, van den Heuvel OA. Distinct Subcortical Volume Alterations in Pediatric and Adult Ocd: A Worldwide Meta- and Mega-Analysis. Am J Psychiatry. Epub 2016 Sep 9

18. Borchert MS, Bruce S, Wirta D, Yoelin SG, Lee S, Mao C, VanDenburgh A. An Evaluation of the Safety and Efficacy of Bimatoprost for Eyelash Growth in Pediatric Subjects. Clin Ophthalmol. 2016;10:419-29.

19. Brant Fernandes RA, Koss MJ, Falabella P, Stefanini FR, Maia M, Diniz B, Ribeiro R, Hu Y, Hinton D, Clegg DO, Chader G, Humayun MS. An Innovative Surgical Technique for Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigmented

Epithelium in Yucatan Mini Pigs: Preliminary Results. Ophthalmic Surg Lasers Imaging Retina. 2016 Apr 1;47(4):342-51.

20. Bressler NM, Varma R, Mitchell P, Suner IJ, Dolan C, Ward J, Ferreira A, Ehrlich JS, Turpcu A. Effect of Ranibizumab on the Decision to Drive and Vision Function Relevant to Driving in Patients with Diabetic Macular Edema: Report from Restore, Ride, and Rise Trials. JAMA Ophthalmol. 2016 Feb;134(2):160-6.

21. Brilliant MH, Vaziri K, Connor TB, Jr., Schwartz SG, Carroll JJ, McCarty CA, Schrodi SJ, Hebbring SJ, Kishor KS, Flynn HW, Jr., Moshfeghi AA, Moshfeghi DM, Fini ME, McKay BS. Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-Dopa and Age-Related Macular Degeneration. Am J Med. 2016 Mar;129(3):292-8.

22. Carr AR, Paholpak P, Daianu M, Fong SS, Mather M, Jimenez EE, Thompson PM, Mendez MF. An Investigation of Care-Based Vs. Rule-Based Morality in Frontotemporal Dementia, Alzheimer’s Disease, and Healthy Controls. Neuropsychologia. 2015 Nov;78:73-9.

23. Chadha N, Liu J, Maslin JS, Teng CC. Trends in Ophthalmology Resident Surgical Experience from 2009 to 2015. Clin Ophthalmol. 2016;10:1205-8.

24. Chahal JS, Heur M, Chiu GB. Prosthetic Replacement of the Ocular Surface Ecosystem Scleral Lens Therapy for Exposure Keratopathy. Eye Contact Lens. 2016 May 11.

25. Chiu GB, Theophanous C, Irvine JA. Prose Treatment in Atypical Ocular Graft-Versus-Host Disease. Optom Vis Sci. 2016 Nov;93(11):1444-8.

26. Cho A, Ratliff C, Sampath A, Weiland J. Changes in Ganglion Cell Physiology During Retinal Degeneration Influence Excitability by Prosthetic Electrodes. J Neural Eng. 2016 Apr;13(2):025001.

27. Choi J, Dixon DM, Dansithong W, Abdallah WF, Roos KP, Jordan MC, Trac B, Lee HS, Comai L, Reddy S. Muscleblind-Like 3 Deficit Results in a Spectrum of Age-Associated Pathologies Observed in Myotonic Dystrophy. Sci Rep. 2016;6:30999.

28. Choudhury F, Varma R, Klein R, Gauderman WJ, Azen SP, McKean-Cowdin R. Age-Related Macular Degeneration and Quality of Life in Latinos: The Los Angeles Latino Eye Study. JAMA Ophthalmol. 2016 Jun 1;134(6):683-90.

29. Colom R, Hua X, Martinez K, Burgaleta M, Roman FJ, Gunter JL, Carmona S, Jaeggi SM, Thompson PM. Brain Structural Changes Following Adaptive Cognitive Training Assessed by Tensor-Based Morphometry (Tbm). Neuropsychologia. 2016 Oct;91:77-85.

30. Conlon C, Asch S, Hanson M, Avins A, Levitan B, Roth C, Robbins M, Dworsky M, Seabury SA, Nuckols T. Assessing the Value of High-Quality Care for Work-Associated Carpal Tunnel Syndrome in a Large Integrated Health Care System: Study Design. Perm J. 2016 Fall;20(4):87-95.

31. Couvy-Duchesne B, Ebejer JL, Gillespie NA, Duffy DL, Hickie IB, Thompson PM, Martin NG, de Zubicaray GI, McMahon KL, Medland SE, Wright MJ. Head Motion and Inattention/Hyperactivity Share Common Genetic Influences: Implications for Fmri Studies of Adhd. PLoS One. 2016;11(1):e0146271.

32. Crawford KL, Neu SC, Toga AW. The Image and Data Archive at the Laboratory of Neuro Imaging. Neuroimage. 2016 Jan 1;124(Pt B):1080-3.

33. Cunningham SI, Shi Y, Weiland JD, Falabella P, Olmos de Koo LC, Zacks DN, Tjan BS. Feasibility of Structural and Functional Mri Acquisition with Unpowered Implants in Argus Ii Retinal Prosthesis Patients: A Case Study. Transl Vis Sci Technol. 2015 Dec;4(6):6.

34. da Cruz L, Dorn JD, Humayun MS, Dagnelie G, Handa J, Barale PO, Sahel JA, Stanga PE, Hafezi F, Safran AB, Salzmann J, Santos A, Birch D, Spencer R, Cideciyan AV, de Juan E, Duncan JL, Eliott D, Fawzi A, Olmos de Koo LC, Ho AC, Brown G, Haller J, Regillo C, Del Priore LV, Arditi A, Greenberg RJ. Five-Year Safety and Performance Results from the Argus Ii Retinal Prosthesis System Clinical Trial. Ophthalmology. 2016 Oct;123(10):2248-54.

35. Dagnelie G, Christopher P, Arditi A, da Cruz L, Duncan JL, Ho AC, Olmos de Koo LC, Sahel JA, Stanga PE, Thumann G, Wang Y, Arsiero M, Dorn JD, Greenberg RJ. Performance of Real-World Functional Vision Tasks by Blind Subjects Improves after Implantation with the Argus(R) Ii Retinal Prosthesis System. Clin Exp Ophthalmol. Epub 2016 Aug 6.

36. Daianu M, Mezher A, Mendez MF, Jahanshad N, Jimenez EE, Thompson PM. Disrupted Rich Club Network in Behavioral Variant Frontotemporal Dementia and Early-Onset Alzheimer’s Disease. Hum Brain Mapp. 2016 Mar;37(3):868-83.

37. DeBoer CM, Lee JK, Wheelan BP, Cable C, Shi W, Tai YC, Humayun MS. Biomimetic Accommodating Intraocular Lens Using a Valved Deformable Liquid Balloon. IEEE Trans Biomed Eng. 2016 Jun;63(6):1129-35.

38. DeLoss KS, Le HG, Gire A, Chiu GB, Jacobs DS, Carrasquillo KG. Prose Treatment for Ocular Chronic Graft-Versus-Host Disease as a Clinical Network Expands. Eye Contact Lens. 2016 Jul;42(4):262-6.

39. Deming JD, Pak JS, Shin JA, Brown BM, Kim MK, Aung MH, Lee EJ, Pardue MT, Craft CM. Arrestin 1 and Cone Arrestin 4 Have Unique Roles in Visual Function in an All-Cone Mouse Retina. Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7618-28.

40. Deming JD, Van Craenenbroeck K, Eom YS, Lee EJ, Craft CM. Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4. Adv Exp Med Biol. 2016;854:663-70.

41. Dennis EL, Hua X, Villalon-Reina J, Moran LM, Kernan C, Babikian T, Mink R, Babbitt C, Johnson J, Giza CC, Thompson PM, Asarnow RF. Tensor-Based Morphometry Reveals Volumetric Deficits in Moderate=Severe Pediatric Traumatic Brain Injury. J Neurotrauma. 2016 May 1;33(9):840-52.

42. Dinov ID, Heavner B, Tang M, Glusman G, Chard K, Darcy M, Madduri R, Pa J, Spino C, Kesselman C, Foster I, Deutsch EW, Price ND, Van Horn JD, Ames J, Clark K, Hood L, Hampstead BM, Dauer W, Toga AW. Predictive Big Data Analytics: A Study of Parkinson’s Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations. PLoS One. 2016;11(8):e0157077.

43. Dugel PU, Layton A, Varma R. Diabetic Macular Edema Diagnosis and Treatment in the Real World: An Analysis of Medicare Claims Data (2008 to 2010). Ophthalmic Surg Lasers Imaging Retina. 2016 Mar;47(3):258-67.

44. Duker JS, Puliafito CA. 8 Questions with Dr. Puliafito. Ophthalmic Surg Lasers Imaging Retina. 2016 Mar;47(3):299-300.

PUBLICATIONS

52 usceye.org

45. Duncan JL, Richards TP, Arditi A, da Cruz L, Dagnelie G, Dorn JD, Ho AC, Olmos de Koo LC, Barale PO, Stanga PE, Thumann G, Wang Y, Greenberg RJ. Improvements in Vision-Related Quality of Life in Blind Patients Implanted with the Argus Ii Epiretinal Prosthesis. Clin Exp Optom. Epub 2016 Aug 25.

46. Eandi CM, Charles Messance H, Augustin S, Dominguez E, Lavalette S, Forster V, Hu SJ, Siquieros L, Craft CM, Sahel JA, Tadayoni R, Paques M, Guillonneau X, Sennlaub F. Subretinal Mononuclear Phagocytes Induce Cone Segment Loss Via Il-1beta. Elife. Epub 2016;5.

47. Ediriwickrema LS, Chhadva P, Rodger DC, Ameri H, Rao NA. Intravenous Immunoglobulin in the Treatment of Juvenile Retinitis Pigmentosa-Associated Cystoid Macular Edema and Uveitis. Retin Cases Brief Rep. 2016 Nov 08.

48. Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, Hartung T, Rojas C, Rais R, Tsukamoto T, Semenza GL, Hanes J, Slusher BS, Le A. Combination Therapy with Bptes Nanoparticles and Metformin Targets the Metabolic Heterogeneity of Pancreatic Cancer. Proc Natl Acad Sci USA. 2016 Sep 6;113(36):E5328-36.

49. Falabella P, Stefanini FR, Lue JC, Pfister M, Reyes-Mckinley J, Koss MJ, Teixeira A, Schor P, Humayun MS. Intraocular Pressure Changes During Vitrectomy Using Constellation Vision System’s Intraocular Pressure Control Feature. Retina. 2016 Jul;36(7):1275-80.

50. Fan Q, Witzel T, Nummenmaa A, Van Dijk KR, Van Horn JD, Drews MK, Somerville LH, Sheridan MA, Santillana RM, Snyder J, Hedden T, Shaw EE, Hollinshead MO, Renvall V, Zanzonico R, Keil B, Cauley S, Polimeni JR, Tisdall D, Buckner RL, Wedeen VJ, Wald LL, Toga AW, Rosen BR. Mgh-Usc Human Connectome Project Datasets with Ultra-High B-Value Diffusion Mri. Neuroimage. 2016 Jan 1;124(Pt B):1108-14.

51. Fei C, Chiu CT, Chen X, Chen Z, Ma J, Zhu B, Shung KK, Zhou Q. Ultrahigh Frequency (100 Mhz-300 Mhz) Ultrasonic Transducers for Optical Resolution Medical Imagining. Sci Rep. 2016;6:28360.

52. Fei C, Li Y, Zhu B, Chiu CT, Chen Z, Li D, Yang Y, Kirk Shung K, Zhou Q. Contactless Microparticle Control Via Ultrahigh Frequency Needle Type Single Beam Acoustic Tweezers. Appl Phys Lett. 2016 Oct 24;109(17):173509.

53. Fini ME, Bauskar A, Jeong S, Wilson MR. Clusterin in the Eye: An Old Dog with New Tricks at the Ocular Surface. Exp Eye Res. 2016 Jun;147:57-71.

54. Fini ME, Schwartz SG, Gao X, Jeong S, Patel N, Itakura T, Price MO, Price FW, Jr., Varma R, Stamer WD. Steroid-Induced Ocular Hypertension/Glaucoma: Focus on Pharmacogenomics and Implications for Precision Medicine. Prog Retin Eye Res. Epub 2016 Sep 22.

55. Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJ, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santianez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Yao Y, Ho YY, Martin NG, Wright MJ, O’Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF. Genetic Influences on Schizophrenia and Subcortical Brain Volumes: Large-Scale Proof of Concept. Nat Neurosci. 2016 Mar;19(3):420-31.

56. Fu KA, Nathan R, Dinov ID, Li J, Toga AW. T2-Imaging Changes in the Nigrosome-1 Relate to Clinical Measures of Parkinson’s Disease. Front Neurol. 2016;7:174.

57. Gao X, Nannini DR, Corrao K, Torres M, Chen YI, Fan BJ, Wiggs JL, Taylor KD, James Gauderman W, Rotter JI, Varma R. Genome-Wide Association Study Identifies Wnt7b as a Novel Locus for Central Corneal Thickness in Latinos. Hum Mol Genet. Epub 2016 Sep 20.

58. Garg N, Chang TC, Reiser BJ, Cavuoto KM. A Novel Characterization of Posterior Keratoconus Using Anterior Segment Optical Coherence Tomography in an Infant: A Case Report. BMC Ophthalmol. 2015;15:158.

59. Garg SJ, Dollin M, Hsu J, Storey P, Vander JF. Effect of a Strict ‘No-Talking’ Policy During Intravitreal Injection on Post-Injection Endophthalmitis. Ophthalmic Surg Lasers Imaging Retina. 2015 Nov-Dec;46(10):1028-34.

60. Garg SJ, Dollin M, Storey P, Pitcher JD, 3rd, Fang-Yen NH, Vander J, Hsu J. Microbial Spectrum and Outcomes of Endophthalmitis after Intravitreal Injection Versus Pars Plana Vitrectomy. Retina. 2016 Feb;36(2):351-9.

61. Guadalupe T, Mathias SR, vanErp TG, Whelan CD, Zwiers MP, Abe Y, Abramovic L, Agartz I, Andreassen OA, Arias-Vasquez A, Aribisala BS, Armstrong NJ, Arolt V, Artiges E, Ayesa-Arriola R, Baboyan VG, Banaschewski T, Barker G, Bastin ME, Baune BT, Blangero J, Bokde AL, Boedhoe PS, Bose A, Brem S, Brodaty H, Bromberg U, Brooks S, Buchel C, Buitelaar J, Calhoun VD, Cannon DM, Cattrell A, Cheng Y, Conrod PJ, Conzelmann A, Corvin A, Crespo-Facorro B, Crivello F, Dannlowski U, de Zubicaray GI, de Zwarte SM, Deary IJ, Desrivieres S, Doan NT, Donohoe G, Dorum ES, Ehrlich S, Espeseth T, Fernandez G, Flor H, Fouche JP, Frouin V, Fukunaga M, Gallinat J, Garavan H, Gill M, Suarez AG, Gowland P, Grabe HJ, Grotegerd D, Gruber O, Hagenaars S, Hashimoto R, Hauser TU, Heinz A, Hibar DP, Hoekstra PJ, Hoogman M, Howells FM, Hu H, Hulshoff Pol HE, Huyser C, Ittermann B, Jahanshad N, Jonsson EG, Jurk S, Kahn RS, Kelly S, Kraemer B, Kugel H, Kwon JS, Lemaitre H, Lesch KP, Lochner C, Luciano M, Marquand AF, Martin NG, Martinez-Zalacain I, Martinot JL, Mataix-Cols D, Mather K, McDonald C, McMahon KL, Medland SE, Menchon JM, Morris DW, Mothersill O, Maniega SM, Mwangi B, Nakamae T, Nakao T, Narayanaswaamy JC, Nees F, Nordvik JE, Onnink AM, Opel N, Ophoff R, Paillere Martinot ML, Papadopoulos Orfanos D, Pauli P, Paus T, Poustka L, Reddy JY, Renteria ME, Roiz-Santianez R, Roos A, Royle NA, Sachdev P, Sanchez-Juan P, Schmaal L, Schumann G, Shumskaya E, Smolka MN, Soares JC, Soriano-Mas C, Stein DJ, Strike LT, Toro R, Turner JA, Tzourio-Mazoyer N, Uhlmann A, Hernandez MV, van den Heuvel OA, van der Meer D, van Haren NE, Veltman DJ, Venkatasubramanian G, Vetter NC, Vuletic D, Walitza S, Walter H, Walton E, Wang Z, Wardlaw J, Wen W, Westlye LT, Whelan R, Wittfeld K, Wolfers T, Wright MJ, Xu J, Xu X, Yun JY, Zhao J, Franke B, Thompson PM, Glahn DC, Mazoyer B, Fisher SE, Francks C. Human Subcortical Brain Asymmetries in 15,847 People Worldwide Reveal Effects of Age and Sex. Brain Imaging Behav. 2016 Oct 13.

62. Geruschat DR, Richards TP, Arditi A, da Cruz L, Dagnelie G, Dorn JD, Duncan JL, Ho AC, Olmos de Koo LC, Sahel JA, Stanga PE, Thumann G, Wang V, Greenberg RJ. An Analysis of Observer-Rated

Functional Vision in Patients Implanted with the Argus Ii Retinal Prosthesis System at Three Years. Clin Exp Optom. 2016 May;99(3):227-32.

63. Ghodasra DH, Chen A, Arevalo JF, Birch DG, Branham K, Coley B, Dagnelie G, de Juan E, Devenyi RG, Dorn JD, Fisher A, Geruschat DR, Gregori NZ, Greenberg RJ, Hahn P, Ho AC, Howson A, Huang SS, Iezzi R, Khan N, Lam BL, Lim JI, Locke KG, Markowitz M, Ripley AM, Rankin M, Schimitzek H, Tripp F, Weiland JD, Yan J, Zacks DN, Jayasundera KT. Erratum To: Worldwide Argus Ii Implantation: Recommendations to Optimize Patient Outcomes. BMC Ophthalmol. 2016;16(1):129.

64. Ghodasra DH, Chen A, Arevalo JF, Birch DG, Branham K, Coley B, Dagnelie G, de Juan E, Devenyi RG, Dorn JD, Fisher A, Geruschat DR, Gregori NZ, Greenberg RJ, Hahn P, Ho AC, Howson A, Huang SS, Iezzi R, Khan N, Lam BL, Lim JI, Locke KG, Markowitz M, Ripley AM, Rankin M, Schimitzek H, Tripp F, Weiland JD, Yan J, Zacks DN, Jayasundera KT. Worldwide Argus Ii Implantation: Recommendations to Optimize Patient Outcomes. BMC Ophthalmol. 2016;16:52.

65. Goossens ME, Isa F, Brinkman M, Mak D, Reulen R, Wesselius A, Benhamou S, Bosetti C, Bueno-de-Mesquita B, Carta A, Allam MF, Golka K, Grant EJ, Jiang X, Johnson KC, Karagas MR, Kellen E, La Vecchia C, Lu CM, Marshall J, Moysich K, Pohlabeln H, Porru S, Steineck G, Stern MC, Tang L, Taylor JA, van den Brandt P, Villeneuve PJ, Wakai K, Weiderpass E, White E, Wolk A, Zhang ZF, Buntinx F, Zeegers MP. International Pooled Study on Diet and Bladder Cancer: The Bladder Cancer, Epidemiology and Nutritional Determinants (Blend) Study: Design and Baseline Characteristics. Arch Public Health. 2016;74:30.

66. Gordon GM, LaGier AJ, Ponchel C, Bauskar A, Itakura T, Jeong S, Patel N, Fini ME. A Cell-Based Screening Assay to Identify Pharmaceutical Compounds That Enhance the Regenerative Quality of Corneal Repair. Wound Repair Regen. 2016 Jan-Feb;24(1):89-99.

67. Heiden D, Saranchuk P, Keenan JD, Ford N, Lowinger A, Yen M, McCune J, Rao NA. Eye Examination for Early Diagnosis of Disseminated Tuberculosis in Patients with Aids. Lancet Infect Dis. 2016 Apr;16(4):493-9.

68. Hintiryan H, Foster NN, Bowman I, Bay M, Song MY, Gou L, Yamashita S, Bienkowski MS, Zingg B, Zhu M, Yang XW, Shih JC, Toga AW, Dong HW. The Mouse Cortico-Striatal Projectome. Nat Neurosci. 2016 Aug;19(8):1100-14.

69. Hong BK, Say EA, Chevez-Barrios P, Lee TC, Kim JW. Anterior Chamber Cholesterolosis in a Patient with Retinoblastoma. Digit J Ophthalmol. 2016;22(1):35-7.

70. Hua X, Ching CR, Mezher A, Gutman BA, Hibar DP, Bhatt P, Leow AD, Jack CR, Jr., Bernstein MA, Weiner MW, Thompson PM. Mri-Based Brain Atrophy Rates in Adni Phase 2: Acceleration and Enrichment Considerations for Clinical Trials. Neurobiol Aging. 2016 Jan;37:26-37.

71. Hui J, Yu Q, Ma T, Wang P, Cao Y, Bruning RS, Qu Y, Chen Z, Zhou Q, Sturek M, Cheng JX, Chen W. High-Speed Intravascular Photoacoustic Imaging at 1.7 Mum with a Ktp-Based Opo. Biomed Opt Express. 2015 Nov 1;6(11):4557-66.

72. Humayun MS, de Juan E, Jr., Dagnelie G. The Bionic Eye: A Quarter Century of Retinal Prosthesis Research and Development. Ophthalmology. 2016 Oct;123(10s):S89-s97.

53

73. Israelsen PE, Sadda SR, Dorn JD, Humayun MS, Olmos de Koo LC. Optomap Widefield Imaging of the Argus Ii Retinal Prosthesis in Patients with Retinitis Pigmentosa. Retin Cases Brief Rep. 2016 Fall;10(4):382-5.

74. Jacobsen BH, Berry JL, Jubran R, Kim JW. Orbital Recurrence Following Aggressive Laser Treatment for Recurrent Retinoblastoma. Ocul Oncol Pathol. 2015 Dec;2(2):76-9.

75. Jen M, Nallasamy S. Ocular Manifestations of Genetic Skin Disorders. Clin Dermatol. 2016 Mar-Apr;34(2):242-75.

76. Jena AB, Schoemaker L, Bhattacharya J, Seabury SA. Authors’ Reply to Barbieri and Kovarik, Mariani, and Waxman and Kanzaria. Bmj. 2015;351:h6774.

77. Jena AB, Schoemaker L, Bhattacharya J, Seabury SA. Physician Spending and Subsequent Risk of Malpractice Claims: Observational Study. Bmj. 2015;351:h5516.

78. Jin Y, Huang C, Daianu M, Zhan L, Dennis EL, Reid RI, Jack CR, Jr., Zhu H, Thompson PM. 3d Tract-Specific Local and Global Analysis of White Matter Integrity in Alzheimer’s Disease. Hum Brain Mapp. 2016 Nov 24.

79. Junning L, Yonggang S, Toga AW. Transformation Invariant Control of Voxel-Wise False Discovery Rate. IEEE Trans Med Imaging. 2016 Oct;35(10):2243-57.

80. Kammen A, Law M, Tjan BS, Toga AW, Shi Y. Automated Retinofugal Visual Pathway Reconstruction with Multi-Shell Hardi and Fod-Based Analysis. Neuroimage. 2016 Jan 15;125:767-79.

81. Kang JH, Mollenhauer B, Coffey CS, Toledo JB, Weintraub D, Galasko DR, Irwin DJ, Van Deerlin V, Chen-Plotkin AS, Caspell-Garcia C, Waligorska T, Taylor P, Shah N, Pan S, Zero P, Frasier M, Marek K, Kieburtz K, Jennings D, Tanner CM, Simuni T, Singleton A, Toga AW, Chowdhury S, Trojanowski JQ, Shaw LM. Csf Biomarkers Associated with Disease Heterogeneity in Early Parkinson’s Disease: The Parkinson’s Progression Markers Initiative Study. Acta Neuropathol. 2016 Jun;131(6):935-49.

82. Kashani AH. Stem Cell Therapy in Nonneovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(5):ORSFm1-9.

83. Kashani AH, Zhang Y, Capone A, Jr., Drenser KA, Puliafito CA, Moshfeghi AA, Williams GA, Trese MT. Impaired Retinal Perfusion Resulting from Vitreoretinal Traction: A Mechanism of Retinal Vascular Insufficiency. Ophthalmic Surg Lasers Imaging Retina. 2016 Mar;47(3):1-11.

84. Keator DB, van Erp TG, Turner JA, Glover GH, Mueller BA, Liu TT, Voyvodic JT, Rasmussen J, Calhoun VD, Lee HJ, Toga AW, McEwen S, Ford JM, Mathalon DH, Diaz M, O’Leary DS, Jeremy Bockholt H, Gadde S, Preda A, Wible CG, Stern HS, Belger A, McCarthy G, Ozyurt B, Potkin SG. The Function Biomedical Informatics Research Network Data Repository. Neuroimage. 2016 Jan 1;124(Pt B):1074-9.

85. Kim AY, Chu Z, Shahidzadeh A, Wang RK, Puliafito CA, Kashani AH. Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):362-70.

86. Kim AY, Rodger DC, Shahidzadeh A, Chu Z, Koulisis N, Burkemper B, Jiang X, Pepple KL, Wang RK, Puliafito CA, Rao NA, Kashani AH. Quantifying Retinal Microvascular Changes in Uveitis Using Spectral Domain Optical Coherence Tomography

Angiography (Sd-Octa). Am J Ophthalmol. 2016 Nov;171:101-12.

87. Kim EL, Bernardino CR, Levin F. Orbital Volume Augmentation Using Expandable Hydrogel Implants in Acquired Anophthalmia and Phthisis Bulbi. Orbit. 2016;35(2):91-6.

88. Kim EL, Tran JS, Moshfeghi AA. Self-Reported Characteristics of Retina Specialists in the United States. Ophthalmology. 2016 Feb;123(2):438-40.

89. Kimel M, Leidy NK, Tschosik E, Dolan C, Souied EH, Varma R, Bressler NM. Functional Reading Independence (Fri) Index: A New Patient-Reported Outcome Measure for Patients with Geographic Atrophy. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6298-304.

90. Kochounian H, Zhang Z, Spee C, Hinton DR, Fong HK. Targeting of Exon Vi-Skipping Human Rgr-Opsin to the Plasma Membrane of Pigment Epithelium and Co-Localization with Terminal Complement Complex C5b-9. Mol Vis. 2016;22:213-23.

91. Kochunov P, Fu M, Nugent K, Wright SN, Du X, Muellerklein F, Morrissey M, Eskandar G, Shukla DK, Jahanshad N, Thompson PM, Patel B, Postolache TT, Strauss KA, Shuldiner AR, Mitchell BD, Hong LE. Heritability of Complex White Matter Diffusion Traits Assessed in a Population Isolate. Hum Brain Mapp. 2016 Feb;37(2):525-35.

92. Kochunov P, Ganjgahi H, Winkler A, Kelly S, Shukla DK, Du X, Jahanshad N, Rowland L, Sampath H, Patel B, O’Donnell P, Xie Z, Paciga SA, Schubert CR, Chen J, Zhang G, Thompson PM, Nichols TE, Hong LE. Heterochronicity of White Matter Development and Aging Explains Regional Patient Control Differences in Schizophrenia. Hum Brain Mapp. Epub 2016 Aug 1.

93. Kochunov P, Rowland LM, Fieremans E, Veraart J, Jahanshad N, Eskandar G, Du X, Muellerklein F, Savransky A, Shukla D, Sampath H, Thompson PM, Hong LE. Diffusion-Weighted Imaging Uncovers Likely Sources of Processing-Speed Deficits in Schizophrenia. Proc Natl Acad Sci U S A. 2016 Nov 9.

94. Kochunov P, Thompson PM, Winkler A, Morrissey M, Fu M, Coyle TR, Du X, Muellerklein F, Savransky A, Gaudiot C, Sampath H, Eskandar G, Jahanshad N, Patel B, Rowland L, Nichols TE, O’Connell JR, Shuldiner AR, Mitchell BD, Hong LE. The Common Genetic Influence over Processing Speed and White Matter Microstructure: Evidence from the Old Order Amish and Human Connectome Projects. Neuroimage. 2016 Jan 15;125:189-97.

95. Kontzialis M, Choudhri AF, Patel VR, Subramanian PS, Ishii M, Gallia GL, Aygun N, Blitz AM. High-Resolution 3d Magnetic Resonance Imaging of the Sixth Cranial Nerve: Anatomic and Pathologic Considerations by Segment. J Neuroophthalmol. 2015 Dec;35(4):412-25.

96. Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani AH, Brant R, Zhu D, Clegg DO, Hinton DR, Humayun MS. Subretinal Implantation of a Monolayer of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium: A Feasibility and Safety Study in Yucatan Minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug;254(8):1553-65.

97. Koulisis N, Moysidis SN, Siegel LM, Song JC. Long-Term Follow-up of Amniotic Membrane Graft for the Treatment of Symblepharon in a Patient with Recessive Dystrophic Epidermolysis Bullosa. Cornea. 2016 Sep;35(9):1242-4.

98. La Morgia C, Ross-Cisneros FN, Koronyo Y, Hannibal J, Gallassi R, Cantalupo G, Sambati L, Pan BX, Tozer KR, Barboni P, Provini F, Avanzini P, Carbonelli M, Pelosi A, Chui H, Liguori R, Baruzzi A, Koronyo-Hamaoui M, Sadun AA, Carelli V. Melanopsin Retinal Ganglion Cell Loss in Alzheimer Disease. Ann Neurol. 2016 Jan;79(1):90-109.

99. Lam KH, Li Y, Li Y, Lim HG, Zhou Q, Shung KK. Multifunctional Single Beam Acoustic Tweezer for Non-Invasive Cell/Organism Manipulation and Tissue Imaging. Sci Rep. 2016 Nov 22;6:37554.

100. Lee D, Lee C, Kim S, Zhou Q, Kim J, Kim C. In Vivo near Infrared Virtual Intraoperative Surgical Photoacoustic Optical Coherence Tomography. Sci Rep. 2016 Oct 12;6:35176.

101. Lee R, Khoueir Z, Tsikata E, Chodosh J, Dohlman CH, Chen TC. Long-Term Visual Outcomes and Complications of Boston Keratoprosthesis Type Ii Implantation. Ophthalmology. 2016 Aug 15.

102. Lei H, Johnson LA, Liu S, Moons DS, Ma T, Zhou Q, Rice MD, Ni J, Wang X, Higgins PD, Xu G. Characterizing Intestinal Inflammation and Fibrosis in Crohn’s Disease by Photoacoustic Imaging: Feasibility Study. Biomed Opt Express. 2016 Jul 1;7(7):2837-48.

103. Leng Y, Shi Y, Yu Q, Van Horn JD, Tang H, Li J, Xu W, Ge X, Tang Y, Han Y, Zhang D, Xiao M, Zhang H, Pang Z, Toga AW, Liu S. Phenotypic and Genetic Correlations between the Lobar Segments of the Inferior Fronto-Occipital Fasciculus and Attention. Sci Rep. 2016;6:33015.

104. Levine M, Flores J, Seabury SA, Sanko S, Eckstein M. Impact of the Use of Regional Poison Control Centers in an Urban Ems Dispatch System. J Med Toxicol. Epub 2016 Oct 7.

105. Li B, Shi J, Gutman BA, Baxter LC, Thompson PM, Caselli RJ, Wang Y. Influence of Apoe Genotype on Hippocampal Atrophy over Time - an N=1925 Surface-Based Adni Study. PLoS One. 2016;11(4):e0152901.

106. Li J, Gahm JK, Shi Y, Toga AW. Topological False Discovery Rates for Brain Mapping Based on Signal Height. Neuroimage. 2016 Nov 9.

107. Li J, Ma T, Mohar D, Steward E, Yu M, Piao Z, He Y, Shung KK, Zhou Q, Patel PM, Chen Z. Ultrafast Optical-Ultrasonic System and Miniaturized Catheter for Imaging and Characterizing Atherosclerotic Plaques in Vivo. Sci Rep. 2015;5:18406.

108. Li J, Shi Y, Toga AW. Transformation Invariant Control of Voxel-Wise False Discovery Rate. IEEE Trans Med Imaging. Epub 2016 Apr 14.

109. Li J, Shi Y, Toga AW. Mapping Brain Anatomical Connectivity Using Diffusion Magnetic Resonance Imaging: Structural Connectivity of the Human Brain. IEEE Signal Process Mag. 2016 May;33(3):36-51.

110. Li WL, Buckley J, Sanchez-Lara PA, Maglinte DT, Viduetsky L, Tatarinova TV, Aparicio JG, Kim JW, Au M, Ostrow D, Lee TC, O’Gorman M, Judkins A, Cobrinik D, Triche TJ. A Rapid and Sensitive Next-Generation Sequencing Method to Detect Rb1 Mutations Improves Care for Retinoblastoma Patients and Their Families. J Mol Diagn. 2016 Jul;18(4):480-93.

111. Li Y, Ma J, Martin K, Yu M, Ma T, Dayton P, Jiang X, Shung K, Zhou Q. An Integrated System for Super-Harmonic Contrast-Enhanced Ultrasound Imaging: Design and Intravascular Phantom Imaging Study. IEEE Trans Biomed Eng. Epub 2015 Dec 8.

PUBLICATIONS

54 usceye.org

112. Lupton MK, Strike L, Hansell NK, Wen W, Mather KA, Armstrong NJ, Thalamuthu A, McMahon KL, de Zubicaray GI, Assareh AA, Simmons A, Proitsi P, Powell JF, Montgomery GW, Hibar DP, Westman E, Tsolaki M, Kloszewska I, Soininen H, Mecocci P, Velas B, Lovestone S, Brodaty H, Ames D, Trollor JN, Martin NG, Thompson PM, Sachdev PS, Wright MJ. The Effect of Increased Genetic Risk for Alzheimer’s Disease on Hippocampal and Amygdala Volume. Neurobiol Aging. 2016 Apr;40:68-77.

113. Ly DP, Seabury SA, Jena AB. Differences in Incomes of Physicians in the United States by Race and Sex: Observational Study. Bmj. 2016;353:i2923.

114. Ma J, Luo Y, Sevag Packard RR, Ma T, Ding Y, Abiri P, Tai YC, Zhou Q, Shung KK, Li R, Hsiai T. Ultrasonic Transducer-Guided Electrochemical Impedance Spectroscopy to Assess Lipid-Laden Plaques. Sens Actuators B Chem. 2016 Nov 1;235:154-61.

115. MacEwan JP, Kamat SA, Duffy RA, Seabury SA, Chou JW, Legacy SN, Hartry A, Eramo A, Karson C. Hospital Readmission Rates among Patients with Schizophrenia Treated with Long-Acting Injectables or Oral Antipsychotics. Psychiatr Serv. 2016 Jul 15:appips201500455.

116. Mackey S, Kan KJ, Chaarani B, Alia-Klein N, Batalla A, Brooks S, Cousijn J, Dagher A, de Ruiter M, Desrivieres S, Feldstein Ewing SW, Goldstein RZ, Goudriaan AE, Heitzeg MM, Hutchison K, Li CS, London ED, Lorenzetti V, Luijten M, Martin-Santos R, Morales AM, Paulus MP, Paus T, Pearlson G, Schluter R, Momenan R, Schmaal L, Schumann G, Sinha R, Sjoerds Z, Stein DJ, Stein EA, Solowij N, Tapert S, Uhlmann A, Veltman D, van Holst R, Walter H, Wright MJ, Yucel M, Yurgelun-Todd D, Hibar DP, Jahanshad N, Thompson PM, Glahn DC, Garavan H, Conrod P. Genetic Imaging Consortium for Addiction Medicine: From Neuroimaging to Genes. Prog Brain Res. 2016;224:203-23.

117. Mandell JB, Kim AY, Shahidzadeh A, Ameri H, Puliafito CA, Moshfeghi AA. Widefield Oct Findings of a Patient with Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis. Ophthalmic Surg Lasers Imaging Retina. 2016 Aug 1;47(8):774-7.

118. Marvasti AH, Berry J, Sibug ME, Kim JW, Huang AS. Anterior Segment Scleral Fluorescein Angiography in the Evaluation of Ciliary Body Neoplasm: Two Case Reports. Case Rep Ophthalmol. 2016 Jan-Apr;7(1):30-8.

119. Maslin JS, Teng CC, Chadha N, Liu J. Effect of Supine Body Position on Central Corneal Thickness. Clin Exp Ophthalmol. 2016 Mar 14.

120. Maslin JS, Teng CC, Materin M. Free-Floating, Pigmented Cysts in the Anterior Chamber Causing Ocular Hypertension. Ocul Oncol Pathol. 2016 Oct;2(4):239-41.

121. Mendez MF, Joshi A, Daianu M, Jimenez E, Thompson PM. White Matter Changes Associated with Resting Sympathetic Tone in Frontotemporal Dementia Vs. Alzheimer’s Disease. PLoS One. 2015;10(11):e0142445.

122. Mercado CL, Toy BC, Kistler HB, Moshfeghi DM. Choroidal Metastases from Cutaneous Melanoma. Ophthalmic Surg Lasers Imaging Retina. 2016 May 1;47(5):497.

123. Merchant ND, Pirotta E, Barton TR, Thompson PM. Soundscape and Noise Exposure Monitoring in a Marine Protected Area Using Shipping Data and Time-Lapse Footage. Adv Exp Med Biol.

2016;875:705-12.

124. Merritt H, Pfeiffer ML, Richani K, Phillips ME. Erdheim-Chester Disease with Orbital Involvement: Case Report and Ophthalmic Literature Review. Orbit. 2016 Aug;35(4):221-6.

125. Montagne A, Nation DA, Pa J, Sweeney MD, Toga AW, Zlokovic BV. Brain Imaging of Neurovascular Dysfunction in Alzheimer’s Disease. Acta Neuropathol. 2016 May;131(5):687-707.

126. Montagne A, Toga AW, Zlokovic BV. Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research. JAMA Neurol. 2016 Jan;73(1):13-4.

127. Moysidis SN, Koulisis N, Olmos de Koo LC. Reply. Retin Cases Brief Rep. Epub 2016 Aug 3.

128. Moysidis SN, Koulisis N, Patel VR, Kashani AH, Rao NA, Humayun MS, Rodger DC. The Second Blind Spot: Small Retinal Vessel Vasculopathy after Vaccination against Neisseria Meningitidis and Yellow Fever. Retin Cases Brief Rep. Epub 2016 Sep 2.

129. Murakami Y, Wang D, Burkemper B, Lin SC, Varma R. A Population-Based Assessment of the Agreement between Grading of Goniophotographic Images and Gonioscopy in the Chinese-American Eye Study (Ches). Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4512-6.

130. Murali K, Kang D, Nazari H, Scianmarello N, Cadenas E, Tai YC, Kashani A, Humayun M. Spatial Variations in Vitreous Oxygen Consumption. PLoS One. 2016;11(3):e0149961.

131. Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome Analysis Reveals Rod/Cone Photoreceptor Specific Signatures across Mammalian Retinas. Hum Mol Genet. Epub 2016 Aug 9.

132. Nannini D, Torres M, Chen YD, Taylor KD, Rotter JI, Varma R, Gao X. Reply. Ophthalmology. 2016 Apr;123(4):e31-2.

133. Nannini D, Torres M, Chen YD, Taylor KD, Rotter JI, Varma R, Gao X. African Ancestry Is Associated with Higher Intraocular Pressure in Latinos. Ophthalmology. 2016 Jan;123(1):102-8.

134. Nemiroff J, Kuehlewein L, Rahimy E, Tsui I, Doshi R, Gaudric A, Gorin MB, Sadda S, Sarraf D. Assessing Deep Retinal Capillary Ischemia in Paracentral Acute Middle Maculopathy by Optical Coherence Tomography Angiography. Am J Ophthalmol. 2016 Feb;162:121-32.e1.

135. Nemiroff J, Phasukkijwatana N, Sarraf D. Optical Coherence Tomography Angiography of Deep Capillary Ischemia. Dev Ophthalmol. 2016;56:139-45.

136. Nemiroff J, Phasukkijwatana N, Vaclavik V, Nagiel A, Holz ER, Sarraf D. The Spectrum of Amalric Triangular Choroidal Infarction. Retin Cases Brief Rep. 2016 Oct 11.

137. Neu SC, Crawford KL, Toga AW. Sharing Data in the Global Alzheimer’s Association Interactive Network. Neuroimage. 2016 Jan 1;124(Pt B):1168-74.

138. Nguyen AH, Dastiridou AI, Chiu GB, Francis BA, Lee OL, Chopra V. Glaucoma Surgical Considerations for Prose Lens Use in Patients with Ocular Surface Disease. Cont Lens Anterior Eye. 2016 Aug;39(4):257-61.

139. Nho K, Horgusluoglu E, Kim S, Risacher SL, Kim D, Foroud T, Aisen PS, Petersen RC, Jack CR, Jr., Shaw LM, Trojanowski JQ, Weiner MW, Green RC,

Toga AW, Saykin AJ. Integration of Bioinformatics and Imaging Informatics for Identifying Rare Psen1 Variants in Alzheimer’s Disease. BMC Med Genomics. 2016;9 Suppl 1:30.

140. Ning B, Sun N, Cao R, Chen R, Kirk Shung K, Hossack JA, Lee JM, Zhou Q, Hu S. Ultrasound-Aided Multi-Parametric Photoacoustic Microscopy of the Mouse Brain. Sci Rep. 2015;5:18775.

141. Okada AK, Teranishi K, Isas JM, Bedrood S, Chow RH, Langen R. Diabetic Risk Factors Promote Islet Amyloid Polypeptide Misfolding by a Common, Membrane-Mediated Mechanism. Sci Rep. 2016;6:31094.

142. O’Keefe GA, Rao NA. Vogt-Koyanagi-Harada Disease. Surv Ophthalmol. Epub 2016 May 27.

143. Olmos de Koo LC, Puliafito CA. 8 Questions with Dr. Puliafito. Ophthalmic Surg Lasers Imaging Retina. 2016 Feb;47(2):194-6.

144. Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques. Ann Biomed Eng. 2016 Sep;44(9):2695-706.

145. Pak JS, Lee EJ, Craft CM. The Retinal Phenotype of Grk1-/- Is Compromised by a Crb1 Rd8 Mutation. Mol Vis. 2015;21:1281-94.

146. Perez-Straziota C, Randleman JB. Femtosecond-Assisted Lasik: Complications and Management. Int Ophthalmol Clin. 2016 Spring;56(2):59-66.

147. Pfeiffer ML, Hacopian A, Merritt H, Phillips ME, Richani K. Complete Vision Loss Following Orbital Cellulitis Secondary to Acute Dacryocystitis. Case Rep Ophthalmol Med. 2016;2016:9630698.

148. Plis SM, Sarwate AD, Wood D, Dieringer C, Landis D, Reed C, Panta SR, Turner JA, Shoemaker JM, Carter KW, Thompson PM, Hutchison K, Calhoun VD. Coinstac: A Privacy Enabled Model and Prototype for Leveraging and Processing Decentralized Brain Imaging Data. Front Neurosci. 2016;10:365.

149. Puliafito CA. Introduction. Ophthalmic Surg Lasers Imaging Retina. 2016 Apr;47(4 Suppl):S4.

150. Puliafito CA, Cousins SW, Bacharach J, Gonzalez VH, Holekamp NM, Merrill PT, Ohr MP, Parrish RK, 2nd, Riemann CD. Forming a Consensus: Data and Guidance for Physicians Treating Diabetic Macular Edema. Ophthalmic Surg Lasers Imaging Retina. 2016 Apr;47(4 Suppl):S4-s15.

151. Puliafito CA, Dugel PU, Cousins SW, Packo KH, Eaton AM, Parrish RK, 2nd, Kiss S, Reichel E. Improving Outcomes for Patients with Diabetic Macular Edema. Ophthalmic Surg Lasers Imaging Retina. 2015 Nov-Dec;46(10):S5-s15.

152. Qu Y, Ma T, He Y, Zhu J, Dai C, Yu M, Huang S, Lu F, Shung KK, Zhou Q, Chen Z. Acoustic Radiation Force Optical Coherence Elastography of Corneal Tissue. IEEE J Sel Top Quantum Electron. 2016 May-Jun;22(3).

153. Quinn LR, Meharg AA, van Franeker JA, Graham IM, Thompson PM. Validating the Use of Intrinsic Markers in Body Feathers to Identify Inter-Individual Differences in Non-Breeding Areas of Northern Fulmars. Mar Biol. 2016;163:64.

154. Rahimy E, Rayess N, Ho AC, Regillo CD. Treatment Outcomes for Neovascular Age-Related Macular

55

Degeneration Patients with Initial Vision Better Than 20/40 Using a Treat-and-Extend Regimen. Retina. 2016 May;36(5):875-80.

155. Rahimy E, Shahlaee A, Ehmann D, Rayess N, Fineman MS, Garg SJ, Ho AC, Hsu J. Early Optical Coherence Tomography Findings after Vitreomacular Traction Release. Ophthalmology. 2016 Sep;123(9):2046-7.

156. Raji CA, Merrill DA, Eyre H, Mallam S, Torosyan N, Erickson KI, Lopez OL, Becker JT, Carmichael OT, Gach HM, Thompson PM, Longstreth WT, Kuller LH. Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study. J Alzheimers Dis. 2016;52(2):719-29.

157. Randleman JB. Ectasia after Corneal Refractive Surgery: Nothing to Smile About. J Refract Surg. 2016 Jul 1;32(7):434-5.

158. Randleman JB, Khandelwal SS, Hafezi F. Corneal Cross-Linking. Surv Ophthalmol. 2015 Nov-Dec;60(6):509-23.

159. Rayess N, Rahimy E, Shah CP, Wolfe JD, Chen E, DeCroos FC, Storey P, Garg SJ, Hsu J. Incidence and Clinical Features of Post-Injection Endophthalmitis According to Diagnosis. Br J Ophthalmol. 2016 Aug;100(8):1058-61.

160. Rayess N, Rahimy E, Storey P, Shah CP, Wolfe JD, Chen E, DeCroos FC, Garg SJ, Hsu J. Postinjection Endophthalmitis Rates and Characteristics Following Intravitreal Bevacizumab, Ranibizumab, and Aflibercept. Am J Ophthalmol. 2016 May;165:88-93.

161. Rayess N, Rahimy E, Ying GS, Pefkianaki M, Franklin J, Regillo CD, Ho AC, Hsu J. Baseline Choroidal Thickness as a Predictor for Treatment Outcomes in Central Retinal Vein Occlusion. Am J Ophthalmol. 2016 Aug 24.

162. Reed DC, Juhn AT, Rayess N, Hsu J, Chiang A. Outcomes of Retinal Detachment Repair after Posterior Open Globe Injury. Retina. 2016 Apr;36(4):758-63.

163. Reichel E, Puliafito CA. 8 Questions with Dr. Puliafito. Ophthalmic Surg Lasers Imaging Retina. 2016 Jan;47(1):96-4.

164. Richter GM, Coleman AL. Minimally Invasive Glaucoma Surgery: Current Status and Future Prospects. Clin Ophthalmol. 2016;10:189-206.

165. Richter GM, Zhang X, Tan O, Francis BA, Chopra V, Greenfield DS, Varma R, Schuman JS, Huang D. Regression Analysis of Optical Coherence Tomography Disc Variables for Glaucoma Diagnosis. J Glaucoma. 2016 Aug;25(8):634-42.

166. Riedel BC, Thompson PM, Brinton RD. Age, Apoe and Sex: Triad of Risk of Alzheimer’s Disease. J Steroid Biochem Mol Biol. 2016 Jun;160:134-47.

167. Rodger DC, Kim EL, Rao NA. Ophthalmomyiasis Interna. Ophthalmology. 2016 Feb;123(2):247.

168. Roussotte FF, Narr KL, Small GW, Thompson PM. The C677t Variant in Mthfr Modulates Associations between Blood-Based and Cerebrospinal Fluid Biomarkers of Neurodegeneration. Neuroreport. 2016 Aug 17;27(12):948-51.

169. Ryabets-Lienhard A, Stewart C, Borchert MS, Geffner ME. The Optic Nerve Hypoplasia Spectrum: Review of the Literature and Clinical Guidelines. Adv Pediatr. 2016 Aug;63(1):127-46.

170. Sadun AA, Karanjia R, Pan BX, Ross-Cisneros FN,

Carelli V. Reactive Oxygen Species in Mitochondrial Optic Neuropathies: Comment. J Neuroophthalmol. 2015 Dec;35(4):445-6.

171. Samimi DB, Ediriwickrema LS, Bielory BP, Miller D, Lee W, Johnson TE. Microbiology and Biofilm Trends of Silicone Lacrimal Implants: Comparing Infected Versus Routinely Removed Stents. Ophthal Plast Reconstr Surg. Epub 2015 Nov 19.

172. Sanguansak T, Morley K, Morley M, Kusakul S, Lee R, Shieh E, Yospaiboon Y, Bhoomibunchoo C, Chai-Ear S, Joseph A, Agarwal I. Comparing Smartphone Camera Adapters in Imaging Post-Operative Cataract Patients. J Telemed Telecare. Epub 2016 Feb 4.

173. Santhiago MR, Smajda D, Wilson SE, Randleman JB. Relative Contribution of Flap Thickness and Ablation Depth to the Percentage of Tissue Altered in Ectasia after Laser in Situ Keratomileusis. J Cataract Refract Surg. 2015 Nov;41(11):2493-500.

174. Schallhorn SC, Venter JA, Teenan D, Hannan SJ, Hettinger KA, Pelouskova M, Schallhorn JM. Patient-Reported Outcomes 5 Years after Laser in Situ Keratomileusis. J Cataract Refract Surg. 2016 Jun;42(6):879-89.

175. Schallhorn SC, Venter JA, Teenan D, Schallhorn JM, Hettinger KA, Hannan SJ, Pelouskova M. Outcomes of Excimer Laser Enhancements in Pseudophakic Patients with Multifocal Intraocular Lens. Clin Ophthalmol. 2016;10:765-76.

176. Schwartz AL, Pesa J, Doshi D, Fastenau J, Seabury SA, Roberts ET, Grabowski DC. Medicaid Managed Care Penetration and Drug Utilization for Patients with Serious Mental Illness. Am J Manag Care. 2016 May;22(5):346-53.

177. Scott JA, Braskie MN, Tosun D, Maillard P, Thompson PM, Weiner M, DeCarli C, Carmichael OT. Cerebral Amyloid Is Associated with Greater White-Matter Hyperintensity Accrual in Cognitively Normal Older Adults. Neurobiol Aging. 2016 Aug 24;48:48-52.

178. Scott JA, Braskie MN, Tosun D, Thompson PM, Weiner M, DeCarli C, Carmichael OT. Cerebral Amyloid and Hypertension Are Independently Associated with White Matter Lesions in Elderly. Front Aging Neurosci. 2015;7:221.

179. Seabury SA. Letter. J Manag Care Spec Pharm. 2016 Nov;22(11):1222.

180. Shafrin J, Ganguli A, Gonzalez YS, Shim JJ, Seabury SA. Geographic Variation in the Quality and Cost of Care for Patients with Rheumatoid Arthritis. J Manag Care Spec Pharm. 2016 Dec;22(12):1472-81.

181. Shan ZY, Vinkhuyzen AA, Thompson PM, McMahon KL, Blokland GA, de Zubicaray GI, Calhoun V, Martin NG, Visscher PM, Wright MJ, Reutens DC. Genes Influence the Amplitude and Timing of Brain Hemodynamic Responses. Neuroimage. 2016 Jan 1;124(Pt A):663-71.

182. Shen KK, Dore V, Rose S, Fripp J, McMahon KL, de Zubicaray GI, Martin NG, Thompson PM, Wright MJ, Salvado O. Heritability and Genetic Correlation between the Cerebral Cortex and Associated White Matter Connections. Hum Brain Mapp. 2016 Jun;37(6):2331-47.

183. Shieh E, Lee R, Que C, Srinivasan V, Guo R, DeLuna R, Pandit S, Simavli H, Seevaratnam R, Tsikata E, de Boer J, Chen TC. Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans. Am J Ophthalmol. 2016 Sep;169:168-78.

184. Shin JA, Kim HS, Vargas A, Yu WQ, Eom YS, Craft CM, Lee EJ. Inhibition of Matrix Metalloproteinase 9 Enhances Rod Survival in the S334ter-Line3 Retinitis Pigmentosa Model. PLoS One. 2016;11(11):e0167102.

185. Sinha Roy A, Rocha KM, Randleman JB, Stulting RD, Dupps WJ, Jr. Corrigendum to “Inverse Computational Analysis of in Vivo Corneal Elastic Modulus Change after Collagen Crosslinking for Keratoconus” [Exp. Eye Res. 113c (2013) 92-104]. Exp Eye Res. 2016 Apr;145:472.

186. Sivakumar RR, Rao NA. Anterior Segment Ischemia in Viper Bite. Ocul Immunol Inflamm. 2016;24(1):49-54.

187. Soni NG, Hoover CK, Da Silva H, Jeng BH. Preservation of the Corneal Epithelium in Different Corneal Storage Media. Cornea. 2015 Nov;34(11):1400-3.

188. Soni NG, Jeng BH. Blood-Derived Topical Therapy for Ocular Surface Diseases. Br J Ophthalmol. 2016 Jan;100(1):22-7.

189. Sood AB, Debiec MR, Yeh S, Grossniklaus HE, Randleman JB. Microsporidial Stromal Keratitis and Endophthalmitis in an Immunocompetent Patient. J Ophthalmic Inflamm Infect. 2016 Dec;6(1):30.

190. Sousa MC, Biteli LG, Dorairaj S, Maslin JS, Leite MT, Prata TS. Suitability of the Visual Field Index According to Glaucoma Severity. J Curr Glaucoma Pract. 2015 Sep-Dec;9(3):65-8.

191. Sridhar J, Yonekawa Y, Kuriyan AE, Joseph A, Thomas BJ, Liang MC, Rayess N, Relhan N, Wolfe JD, Shah CP, Witkin AJ, Flynn HW, Jr., Garg SJ. Microbiologic Spectrum and Visual Outcomes of Acute-Onset Endophthalmitis Undergoing Therapeutic Pars Plana Vitrectomy. Retina. 2016 Oct 21.

192. Stewart C, Garcia-Filion P, Fink C, Ryabets-Lienhard A, Geffner ME, Borchert MS. Efficacy of Growth Hormone Replacement on Anthropometric Outcomes, Obesity, and Lipids in Children with Optic Nerve Hypoplasia and Growth Hormone Deficiency. Int J Pediatr Endocrinol. 2016;2016:5.

193. Storey P, Dollin M, Rayess N, Pitcher J, Reddy S, Vander J, Hsu J, Garg S. The Effect of Prophylactic Topical Antibiotics on Bacterial Resistance Patterns in Endophthalmitis Following Intravitreal Injection. Graefes Arch Clin Exp Ophthalmol. 2016 Feb;254(2):235-42.

194. Storey P, Philander SA, Ter-Zakarian A, Rao NA, Rodger DC. Ultra-Wide-Field Fluorescein Angiography in Microscopic Polyangiitis. Case Rep Ophthalmol Med. 2016;2016:9834684.

195. Storey P, Kim EL, Patel V. Ptosis, Miosis, and Intermittent Esotropia Following Pituitary Adenoma Resection. JAMA Ophthalmol. 2016 Aug 1;134(8):941-2.

196. Storey P, Murchison AP, Pizzi LT, Hark LA, Dai Y, Leiby BE, Haller JA. Impact of Physician Communication on Diabetic Eye Examination Adherence: Results from a Retrospective Cohort Analysis. Retina. 2016 Jan;36(1):20-7.

197. Storey P, Ter-Zakarian A, Rao N, Rodger DC. Severe Bilateral Retinal Vascular Occlusion as First Presentation of Systemic Lupus Erythematosus and Antiphospholipid Syndrome. Retin Cases Brief Rep. 2016 Aug 19.

PUBLICATIONS

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198. Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Forster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL. Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the Dian Study Group. PLoS One. 2016;11(3):e0152082.

199. Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Forster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL. Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the Dian Study Group. PLoS One. 2016;11(9):e0163669.

200. Suner IJ, Bressler NM, Varma R, Dolan CM, Ward J, Turpcu A. Responsiveness of the National Eye Institute Visual Function Questionnaire-25 to Visual Acuity Gains in Patients with Diabetic Macular Edema: Evidence from the Ride and Rise Trials. Retina. 2016 Sep 23.

201. Tamhankar MA, Lesniak SP, Nallasamy S, Woo JH. Tacrolimus-Induced Cerebral Blindness in a Liver Transplant Patient. Indian J Ophthalmol. 2016 Jul;64(7):541.

202. Tan JJ, George MS, Olmos de Koo LC. The Bandage Lens Technique: A Novel Method to Improve Intraoperative Visualization and Fluidic Stabilization During Vitrectomy in Cases of Penetrating Ocular Trauma. Retina. 2016 Jul;36(7):1395-8.

203. Tan JJ, Narang S, Purewal B, Langer PD, Blaydon S, Schwarcz RM, McCormick SA, Kim JY, Walrath JD, Burt BO, Shinder R. Extranodal Rosai-Dorfman Disease of the Orbit: Clinical Features of 8 Cases. Ophthal Plast Reconstr Surg. Epub 2015 Nov 11.

204. Tang M, Li Y, Chamberlain W, Louie DJ, Schallhorn JM, Huang D. Differentiating Keratoconus and Corneal Warpage by Analyzing Focal Change Patterns in Corneal Topography, Pachymetry, and Epithelial Thickness Maps. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):Oct544-9.

205. Tao C, Nichols TE, Hua X, Ching CR, Rolls ET, Thompson PM, Feng J. Generalized Reduced Rank Latent Factor Regression for High Dimensional Tensor Fields, and Neuroimaging-Genetic Applications. Neuroimage. Epub 2016 Sep 22.

206. Tate DF, Wade BS, Velez CS, Drennon AM, Bolzenius J, Gutman BA, Thompson PM, Lewis JD, Wilde EA, Bigler ED, Shenton ME, Ritter JL, York GE. Volumetric and Shape Analyses of Subcortical Structures in United States Service Members with Mild Traumatic Brain Injury. J Neurol. 2016 Oct;263(10):2065-79.

207. Terp S, Seabury SA, Arora S, Eads A, Lam CN, Menchine M. Enforcement of the Emergency Medical Treatment and Labor Act, 2005 to 2014. Ann Emerg Med. Epub 2016 Aug 1.

208. Thackeray SJ, Henrys PA, Hemming D, Bell JR, Botham MS, Burthe S, Helaouet P, Johns DG, Jones

ID, Leech DI, Mackay EB, Massimino D, Atkinson S, Bacon PJ, Brereton TM, Carvalho L, Clutton-Brock TH, Duck C, Edwards M, Elliott JM, Hall SJ, Harrington R, Pearce-Higgins JW, Hoye TT, Kruuk LE, Pemberton JM, Sparks TH, Thompson PM, White I, Winfield IJ, Wanless S. Phenological Sensitivity to Climate across Taxa and Trophic Levels. Nature. 2016 Jul 14;535(7611):241-5.

209. Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y, Nazari H, Stefanini F, Falabella P, Clegg DO, Hinton DR, Humayun MS. Survival and Functionality of Hesc-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in Rcs Rats. Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2877-87.

210. Thompson PM. Cracking the Brain’s Genetic Code. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15269-70.

211. Thompson PM, Andreassen OA, Arias-Vasquez A, Bearden CE, Boedhoe PS, Brouwer RM, Buckner RL, Buitelaar JK, Bulayeva KB, Cannon DM, Cohen RA, Conrod PJ, Dale AM, Deary IJ, Dennis EL, de Reus MA, Desrivieres S, Dima D, Donohoe G, Fisher SE, Fouche JP, Francks C, Frangou S, Franke B, Ganjgahi H, Garavan H, Glahn DC, Grabe HJ, Guadalupe T, Gutman BA, Hashimoto R, Hibar DP, Holland D, Hoogman M, Pol HE, Hosten N, Jahanshad N, Kelly S, Kochunov P, Kremen WS, Lee PH, Mackey S, Martin NG, Mazoyer B, McDonald C, Medland SE, Morey RA, Nichols TE, Paus T, Pausova Z, Schmaal L, Schumann G, Shen L, Sisodiya SM, Smit DJ, Smoller JW, Stein DJ, Stein JL, Toro R, Turner JA, van den Heuvel MP, van den Heuvel OL, van Erp TG, van Rooij D, Veltman DJ, Walter H, Wang Y, Wardlaw JM, Whelan CD, Wright MJ, Ye J. Enigma and the Individual: Predicting Factors That Affect the Brain in 35 Countries Worldwide. Neuroimage. Epub 2015 Dec 4.

212. Thornton Snider J, Seabury SA, Lopez J, McKenzie S, Goldman DP. Impact of Type 2 Diabetes Medication Cost Sharing on Patient Outcomes and Health Plan Costs. Am J Manag Care. 2016 Jun;22(6):433-40.

213. Thulasi P, Khandelwal SS, Randleman JB. Intraocular Lens Alignment Methods. Curr Opin Ophthalmol. 2016 Jan;27(1):65-75.

214. Thulasi P, Kim SW, Shetty R, Randleman JB. Recalcitrant Epithelial Ingrowth after Smile Treated with a Hydrogel Ocular Sealant. J Refract Surg. 2015 Dec;31(12):847-50.

215. Thylur DS, Jacobs RE, Go JL, Toga AW, Niparko JK. Ultra-High-Field Magnetic Resonance Imaging of the Human Inner Ear at 11.7 Tesla. Otol Neurotol. 2016 Oct 12.

216. Toga AW, Neu SC, Bhatt P, Crawford KL, Ashish N. The Global Alzheimer’s Association Interactive Network. Alzheimers Dement. 2016 Jan;12(1):49-54.

217. Tomkins-Netzer O, Lightman S, Drye L, Kempen J, Holland GN, Rao NA, Stawell RJ, Vitale A, Jabs DA. Outcome of Treatment of Uveitic Macular Edema: The Multicenter Uveitis Steroid Treatment Trial 2-Year Results. Ophthalmology. 2015 Nov;122(11):2351-9.

218. Toy BC, Aguinaldo T, Eliason J, Egbert J. Non-Mydriatic Fundus Camera Screening for Referral-Warranted Diabetic Retinopathy in a Northern California Safety-Net Setting. Ophthalmic Surg Lasers Imaging Retina. 2016 Jul 1;47(7):636-42.

219. Toy BC, Myung DJ, He L, Pan CK, Chang RT, Polkinhorne A, Merrell D, Foster D, Blumenkranz MS. Smartphone-Based Dilated Fundus Photography and

near Visual Acuity Testing as Inexpensive Screening Tools to Detect Referral Warranted Diabetic Eye Disease. Retina. 2016 May;36(5):1000-8.

220. Toy BC, Schachar IH, Tan GS, Moshfeghi DM. Chronic Vascular Arrest as a Predictor of Bevacizumab Treatment Failure in Retinopathy of Prematurity. Ophthalmology. 2016 Oct;123(10):2166-75.

221. Tsikata E, Lee R, Shieh E, Simavli H, Que CJ, Guo R, Khoueir Z, de Boer J, Chen TC. Comprehensive Three-Dimensional Analysis of the Neuroretinal Rim in Glaucoma Using High-Density Spectral-Domain Optical Coherence Tomography Volume Scans. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5498-508.

222. Usui Y, Rao NA, Takase H, Tsubota K, Umazume K, Diaz-Aguilar D, Kezuka T, Mochizuki M, Goto H, Sugita S. Comprehensive Polymerase Chain Reaction Assay for Detection of Pathogenic DNA in Lymphoproliferative Disorders of the Ocular Adnexa. Sci Rep. 2016 Nov 10;6:36621.

223. Varma R, Choudhury F, Chen S, Wu S, Hsu C, Torres M, Klein R, Azen SP, McKean-Cowdin R. Prevalence of Age-Related Macular Degeneration in Chinese American Adults: The Chinese American Eye Study. JAMA Ophthalmol. Epub 2016 Apr 7.

224. Varma R, Jiang X. The Role of Contextual Factors in Racial/Ethnic Disparities in Eye Care Use. JAMA Ophthalmol. Epub 2016 Aug 25.

225. Varma R, Kim JS, Burkemper BS, Wen G, Torres M, Hsu C, Choudhury F, Azen SP, McKean-Cowdin R. Prevalence and Causes of Visual Impairment and Blindness in Chinese American Adults: The Chinese American Eye Study. JAMA Ophthalmol. 2016 Jul 1;134(7):785-93.

226. Varma R, Torres M, McKean-Cowdin R, Rong F, Hsu C, Jiang X. Prevalence of Refractive Error in Adult Chinese Americans: The Chinese American Eye Study. Am J Ophthalmol. 2016 Oct 18.

227. Varma R, Vajaranant TS, Burkemper B, Wu S, Torres M, Hsu C, Choudhury F, McKean-Cowdin R. Visual Impairment and Blindness in Adults in the United States: Demographic and Geographic Variations from 2015 to 2050. JAMA Ophthalmol. 2016 Jul 1;134(7):802-9.

228. Varma R, Wen G, Jiang X, Hsu C, Torres M, Klein R, Azen SP, McKean-Cowdin R. Prevalence of Diabetic Retinopathy in Adult Chinese American Individuals: The Chinese American Eye Study. JAMA Ophthalmol. Epub 2016 Apr 7.

229. Vaziri K, Schwartz SG, Flynn HW, Jr., Kishor KS, Moshfeghi AA. Eye-Related Emergency Department Visits in the United States, 2010. Ophthalmology. 2016 Apr;123(4):917-9.

230. Vaziri K, Schwartz SG, Kishor KS, Fortun JA, Moshfeghi AA, Smiddy WE, Flynn HW, Jr. Rates of Reoperation and Retinal Detachment after Macular Hole Surgery. Ophthalmology. 2016 Jan;123(1):26-31.

231. Wade BS, Joshi SH, Njau S, Leaver AM, Vasavada M, Woods RP, Gutman BA, Thompson PM, Espinoza R, Narr KL. Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder. Neuropsychopharmacology. 2016 Sep;41(10):2481-91.

232. Wang B, Weiland JD. Analysis of the Peak Resistance Frequency Method. IEEE Trans Biomed Eng. Epub 2015 Dec 17.

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233. Wang B, Weiland JD. Analysis of the Peak Resistance Frequency Method. IEEE Trans Biomed Eng. 2016 Oct;63(10):2086-94.

234. Weitz AC, Nanduri D, Behrend MR, Gonzalez-Calle A, Greenberg RJ, Humayun MS, Chow RH, Weiland JD. Improving the Spatial Resolution of Epiretinal Implants by Increasing Stimulus Pulse Duration. Sci Transl Med. 2015 Dec 16;7(318):318ra203.

235. Wendelken LA, Jahanshad N, Rosen HJ, Busovaca E, Allen I, Coppola G, Adams C, Rankin KP, Milanini B, Clifford K, Wojta K, Nir TM, Gutman BA, Thompson PM, Valcour V. Apoe Epsilon4 Is Associated with Cognition, Brain Integrity and Atrophy in Hiv over Age 60. J Acquir Immune Defic Syndr. Epub 2016 May 25.

236. Whelan CD, Hibar DP, van Velzen LS, Zannas AS, Carrillo-Roa T, McMahon K, Prasad G, Kelly S, Faskowitz J, deZubiracay G, Iglesias JE, van Erp TG, Frodl T, Martin NG, Wright MJ, Jahanshad N, Schmaal L, Samann PG, Thompson PM. Heritability and Reliability of Automatically Segmented Human Hippocampal Formation Subregions. Neuroimage. 2016 Mar;128:125-37.

237. Wolle MA, Randleman JB, Woodward MA. Complications of Refractive Surgery: Ectasia after Refractive Surgery. Int Ophthalmol Clin. 2016 Spring;56(2):127-39.

238. Wood EH, Moshfeghi AA, Nudleman ED, Moshfeghi DM. Evaluation of Visunex Medical’s Panocam(Tm) Lt and Panocam(Tm) Pro Wide-Field Imaging Systems for the Screening of Rop in Newborn Infants. Expert Rev Med Devices. 2016 Aug;13(8):705-12.

239. Xu BY, Israelsen P, Pan BX, Wang D, Jiang X, Varma R. Benefit of Measuring Anterior Segment Structures Using an Increased Number of Optical Coherence Tomography Images: The Chinese American Eye Study. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6313-9.

240. Xu SC, Chow J, Liu J, Li L, Maslin JS, Chadha N, Chen B, Teng CC. Risk Factors for Visual Impairment Associated with Corneal Diseases in Southern China. Clin Ophthalmol. 2016;10:777-82.

241. Yang X, Shi L, Daianu M, Tong H, Liu Q, Thompson PM. Blockwise Human Brain Network Visual Comparison Using Nodetrix Representation. IEEE Trans Vis Comput Graph. 2016 Aug 5.

242. Yang Y, Joshi SH, Jahanshad N, Thompson PM, Baker LA. Neural Correlates of Proactive and Reactive Aggression in Adolescent Twins. Aggress Behav. 2016 Oct 21.

243. Yu WQ, Eom YS, Shin JA, Nair D, Grzywacz SX, Grzywacz NM, Craft CM, Lee EJ. Reshaping the Cone-Mosaic in a Rat Model of Retinitis Pigmentosa: Modulatory Role of Zo-1 Expression in Dl-Alpha-Aminoadipic Acid Reshaping. PLoS One. 2016;11(3):e0151668.

244. Yue L, Weiland JD, Roska B, Humayun MS. Retinal Stimulation Strategies to Restore Vision: Fundamentals and Systems. Prog Retin Eye Res. 2016 Jul;53:21-47.

245. Zhang J, Stonnington C, Li Q, Shi J, Bauer RJ, 3rd, Gutman BA, Chen K, Reiman EM, Thompson PM, Ye J, Wang Y. Applying Sparse Coding to Surface Multivariate Tensor-Based Morphometry to Predict Future Cognitive Decline. Proc IEEE Int Symp Biomed Imaging. 2016 Apr;2016:646-50.

246. Zhang W, Shi J, Stonnington C, Bauer RJ, 3rd, Gutman BA, Chen K, Thompson PM, Reiman EM, Caselli RJ, Wang Y. Morphometric Analysis of Hippocampus and Lateral Ventricle Reveals Regional Difference between Cognitively Stable and Declining Persons. Proc IEEE Int Symp Biomed Imaging. 2016 Apr;2016:14-8.

247. Zhang X, Dastiridou A, Francis BA, Tan O, Varma R, Greenfield DS, Schuman JS, Sehi M, Chopra V, Huang D. Baseline Fourier-Domain Oct Structural Risk Factors for Visual Field Progression in the Advanced Imaging for Glaucoma Study. Am J Ophthalmol. 2016 Dec;172:94-103.

248. Zhang X, Francis BA, Dastiridou A, Chopra V, Tan O, Varma R, Greenfield DS, Schuman JS, Huang D. Longitudinal and Cross-Sectional Analyses of Age Effects on Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness by Fourier-Domain Oct. Transl Vis Sci Technol. 2016 Mar;5(2):1.

249. Zhang X, Loewen N, Tan O, Greenfield DS, Schuman JS, Varma R, Huang D. Predicting Development of Glaucomatous Visual Field Conversion Using Baseline Fourier-Domain Optical Coherence Tomography. Am J Ophthalmol. 2016 Mar;163:29-37.

250. Zhu B, Xu J, Li Y, Wang T, Xiong K, Lee C, Yang X, Shiiba M, Takeuchi S, Zhou Q, Shung KK. Micro-Particle Manipulation by Single Beam Acoustic Tweezers Based on Hydrothermal Pzt Thick Film. AIP Adv. 2016 Mar;6(3):035102.

251. Zhu D, Berry JL, Ediriwickrema L, Wong K, Lee TC, Murphree AL, Kim JW, Jubran R. Long-Term Outcomes of Group B Eyes in Patients with Retinoblastoma Treated with Short-Course Chemoreduction: Experience from Children’s Hospital Los Angeles/University of Southern California. Ocul Oncol Pathol. 2015 Dec;2(2):105-11.

252. Zhu J, Qi L, Miao Y, Ma T, Dai C, Qu Y, He Y, Gao Y, Zhou Q, Chen Z. 3d Mapping of Elastic Modulus Using Shear Wave Optical Micro-Elastography. Sci Rep. 2016 Oct 20;6:35499.

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