HistoryHistory Developed by the Boots Group in the 1960’s Developed by the Boots Group in the 1960’s Made by Stewart Adams, John Nicholson, Andrew Made by Stewart Adams, John Nicholson, Andrew

RM Dunlop, Jeffrey Bruce Wilson, and Colin RM Dunlop, Jeffrey Bruce Wilson, and Colin BurrowsBurrows

Treated rheumatoid arthritis in the UK and the USTreated rheumatoid arthritis in the UK and the US Won Stewart Adams an OBE and the Boots Group Won Stewart Adams an OBE and the Boots Group

the Queen’s ATA for Ibuprofen’s developmentthe Queen’s ATA for Ibuprofen’s development The Boots Group originally licensed Ibuprofen to The Boots Group originally licensed Ibuprofen to

Whitehall Laboratories and UpjohnWhitehall Laboratories and Upjohn Boots had the patent until 1985, and marketing Boots had the patent until 1985, and marketing

rights until 1986rights until 1986 New “generic” brands were createdNew “generic” brands were created The Sterling Drugs company made Midol 200The Sterling Drugs company made Midol 200

Classification and NicknamesClassification and Nicknames NSAIDNSAID Some Brand namesSome Brand names:: Addaprin®Addaprin® Advil®Advil® Dayquil® Dayquil® Ibifon 600®Ibifon 600® Ibren®Ibren® Menadol®Menadol® Midol® Midol® Motrin®Motrin® Nuprin®Nuprin® Q-Profen®Q-Profen® Tab-Profen®Tab-Profen® Uni-Pro®Uni-Pro® Wal-Profen®Wal-Profen®

Side Effects And LegalitySide Effects And Legality LegalLegal Side effects:Side effects: ConstipationConstipation DiarrheaDiarrhea DizzinessDizziness NervousnessNervousness Unexplained weight gain Unexplained weight gain FeverFever ItchingItching HivesHives Excessive tirednessExcessive tiredness Loss of appetiteLoss of appetite Pale skinPale skin Back painBack pain Vision problemsVision problems HeadacheHeadache ConfusionConfusion

Possible DangersPossible Dangers Dangers:Dangers: NauseaNausea Heartburn Heartburn Gastrointestinal problemsGastrointestinal problems HeadacheHeadache DizzinessDizziness Sleepiness Sleepiness Can be minor/severeCan be minor/severe Someone with these Someone with these

symptoms should stop symptoms should stop taking ibuprofen, or talk to taking ibuprofen, or talk to their doctortheir doctor

Cut back on your dosage, Cut back on your dosage, or switch your pain or switch your pain medicationmedication

Bad enough=SeizuresBad enough=Seizures

Taking ibuprofen for to Taking ibuprofen for to long may result in:long may result in:Chest painsChest painsHeart problemsHeart problemsGastrointestinal problemsGastrointestinal problemsLiver problemsLiver problemsKidney problemsKidney problemsWhich can lead to: Which can lead to: Weakness Weakness Shortness of breathShortness of breathSlurred speechSlurred speechProblems with vision or Problems with vision or balancebalanceCoughing up blood or Coughing up blood or vomitvomitRapid weight gainRapid weight gain

OverdosageOverdosage Symptoms of overdosage: Symptoms of overdosage: DizzinessDizziness Fast eye movements Fast eye movements Slow breathingSlow breathing Blue color around the lips, mouth, Blue color around the lips, mouth,

and noseand nose Overdosage has become common Overdosage has become common

since it became over-the-counter since it became over-the-counter Overdosage symptoms include: Overdosage symptoms include: Abdominal painAbdominal pain NauseaNausea VomitingVomiting Drowsiness Drowsiness Dizziness Dizziness Headache Headache More severe symptoms:More severe symptoms: Gastrointestinal bleedingGastrointestinal bleeding SeizuresSeizures Metabolic acidosisMetabolic acidosis HyperkalaemiaHyperkalaemia HypotensionHypotension BradycardiaBradycardia TachycardiaTachycardia

Atrial fibrillationAtrial fibrillationComaComaHepatic dysfunctionHepatic dysfunctionAcute renal failureAcute renal failureCyanosisCyanosisRespiratory depressionRespiratory depressionCardiac arrestCardiac arrestToxic around 100 mg/kg above Toxic around 100 mg/kg above 400 mg/kg400 mg/kgDeadly amount will varyDeadly amount will varyWays to help an overdosage:Ways to help an overdosage:Stomach pumpingStomach pumpingTherapy for low blood pressureTherapy for low blood pressureGastrointestinal bleeding treatmentGastrointestinal bleeding treatmentAcidosis treatmentsAcidosis treatmentsTherapy for renal toxicityTherapy for renal toxicityThe overdose patient will be closely The overdose patient will be closely monitored in an intensive care unitmonitored in an intensive care unit