Kawasaki Disease
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Transcript of Kawasaki Disease
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In life…
Brave Heart
oblivion …
countless illnesses Most important
Breaks the Heart
the real worryleft hidden…
puzzled
Never to lose heart
Fever
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OBJECTIVES To present a case of atypical
Kawasaki Disease that evolves to complete KD
To present the differential diagnoses of Kawasaki Disease
To review the management and prognosis of Kawasaki Disease
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GENERAL DATA
M.L.2 year old
FemaleFilipino
Pampanga, Davao City
GENERAL DATA
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CHIEF COMPLAINT
FEVER
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HISTORY OF PRESENT ILLNESS
• Remittent moderate to high grade fever, highest temperature at 40˚C and lowest at 38˚C with Paracetamol syrup at 11.7mkdose q4hours
• Headache, coryza, and non-productive cough
• Loose watery stool, yellowish, non-mucoid, non-blood streaked ~ ¼ cup/episode • Persistence of fever
• Redness of both eyes
• Erythematous non-pruritic macular rashes on the trunk and upper extremities
5 days PTA
2 days PTA CBC:Hgb: 111WBC: 9.1Neut: 84Mono: 16Plt: 220 Hct: 37
Advised to consult a
cardiologist if with
persistence of fever
1 days PTA
• 2D echo = moderate pulmonary hypertension with minimal pericardial effusion
• ESR = 61mm/hr
• CRP positive (>6mg/L)
• Given Maalox, Sildenafil, and Aspirin
• Refused admission
AM PTA
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PERSONAL/MEDICAL HISTORY
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REVIEW OF SYSTEMS
GENERAL: (+) irritability and decreased in appetite, (-) seizuresSHEENT: (+) hx of headache. No history of any head injury
No history of otorrhea, tinnitus or otalgiaNo history of epistaxis, gum bleeding, or
difficult swallowingNECK: No history pain, stiffness or limitation in movementRESPIRATORY: No hx of dyspnea or postnasal drip
No history of TB exposureCARDIO: No cyanosis, palpitations or easy fatigabilityGASTRO: No abdominal pain, tenderness or changes in bowel habitURINARY: No dysuria, polyuria or tea-colored urinePERIPHERAL: No phlebitis, pallor or edema MUSCULOSKELETAL: No limitations in movement or no weakness
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PHYSICAL EXAMAwake, afebrile, comfortable, not in
respiratory distress
Vital Signs:BP: 90/60mmHGCR: 120bpmTemp: 35.6˚CRR: 28cpm
Measurement:Wt: 12.73 kgHt: 90cmHC: 48cm
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PHYSICAL EXAM
50th percentile
25th Percentile
50th Percentile
50th Percentile
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PHYSICAL EXAM
SHEENT
• Skin brown, smooth, warm to touch, w/ good turgor
• Atraumatic and normocephalic head• AS w/ PPC; no conjunctival injection,
PERRLA• Dry lips with fissuring and chapping; moist
tongue, uvula at midline, no tonsillopharyngeal congestion
NECK
• Neck was supple with bilateral submandibular lymphadenopathy approximately 1x1 cm in size.
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PHYSICAL EXAM
CHEST
• Equal chest expansion, Clear breath sounds.
• No retraction or deformities
• Adynamic precordium with distinct heart sounds
• NRRR• No murmurs, thrills or heavesHEART
• Abdomen flat, soft, and non-tender with NABS
• Tympanitic on percussion except on areas of liver dullness
• No masses or organomegalyABDOMEN
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PHYSICAL EXAM
EXTREMITIES
• Pulses were strong on all extremities with CRT < 2secs. No edema, desquamation or rashes.
• No deformities and atrophy noted, no limitation on range of motion; no paralysis; no joint instability
MUSCULOSKELETAL
• Intact cranial nerve functions• No pathologic reflexes
NEURO
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SALIENT FEATURES
2 years old Female Moderate to high
grade fever for 5 days
Bilateral submandibular lymphadenopathies 1x1
chapping lips
Irritability headache Cough & coryza LBM Macular rashes on
the trunk and upper extremities
Redness of both eyes
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Fever
DIFFERENTIAL DIAGNOSIS
Scarlet Fever
Dengue Fever
Measles
Roseola InfantumKawasaki Disease
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DENGUE FEVER
Hematocrit 38 33
Platelet count 379 377
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MEASLES
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SCARLET FEVER
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ROSEOLA INFANTUM
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KAWASAKI DISEASE
Fever + 4 Clinical Criteria = Complete Kawasaki DiseaseFever + 2 or 3 Clinical Criteria = Incomplete Kawasaki
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ADMITTING IMPRESSION
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Day of Admission (5TH DOI)
LABS OF ADMISSION
CBCWBC 7.6RBC 4.8Hgb 12.8Hct 38Plt 379Neutro 33Lympho 52Mono 15Eo 0Baso 0
C-Xray: NormalStool Exam: Negative
U/AYellow, slightly cloudy, acidicSp. Gravity: 1.010
Albumin: trace Pus cells: 15-20/hpfMucus: +++
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MEDICATIONS
Paracetamol 250mg/5ml 3.5ml q 4
Sildenafil 50mg tablet ¼tab + 5ml water, 5ml BID
Diphenhydramine 13 mg IVTT 30 min prior IVIG
Al HO2/Mg (Maalox) syrup 5ml TID 30 mins before ASA
Aspirin 300mg 1tab + in 5 ml water, 5 ml TID (70.7mkd)
IVIG 250grams (2mg/kg)
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1ST HD, 6th DOIS/O•(+) Febrile Episodes•(-) Active losses•Fair appetite•Erythematous lips, cracking•Bilateral cervical lymphadenopathies 1x1
AKawasaki Disease,
Incomplete
P•Paracetamol given for fever•Sildenafil 50mg tablet ¼tab + 5ml water, 5ml BID•Aspirin 300mg 1tab + in 5 ml water, 5 ml TID•Maalox syrup 5ml TID 30 mins before ASA•Repeat U/A requested
Repeat U/APus cells: 8-10/hpfEpithelial: +Mucus: ++
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S/O•(-) Febrile episodes•Comfortable•Stable vital signs•Erythematous, cracked lips•Cervical lympadenopathies of about 1.5 x 1.5
AKawasaki Disease,
Complete
P•Paracetamol given for fever•Sildenafil 50mg tablet ¼tab + 5ml water, 5ml BID•Aspirin 300mg 1tab + in 5 ml water, 5 ml TID•Maalox syrup 5ml TID 30 mins before ASA•Repeat CBC requested
Neutro 39Lympho 51Mono
10Eo 0Baso 0
2nd HD, 7th DOI
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3rd HD, 8th DOIS/O•(-) Febrile Episodes x 35˚•(-) Active losses•Good appetite•Bilateral cervical lymphadenopathies 1x1
AKawasaki Disease,
Complete
P•MGH with home medications:•Sildenafil 50mg tablet ¼tab + 5ml water, 5ml BID•Aspirin 300mg 1tab + in 5 ml water, 5 ml TID•Maalox syrup 5ml TID 30 mins before ASA•Follow up with cardiologist after 1week•For repeat 2D-echo after 2 weeks
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Dr. Tomisaku Kawasaki Mucocutaneous lymph
node syndrome Infantile polyarteritis
nodosa an acute Febrile
Vasculitis of childhood UNKNOWN CAUSE
Nelson Textbook of Pediatrics 18th Edition
KAWASAKI DISEASE
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Prevalent in Japan
Children of Japanese ancestry
80% of children – less than 5 years old; median age of illness 2-3 y/o
Americans of Asian and Pacific Island descent
Boys > girls = ~1.5 to 1.7:1
Winter and spring
EPIDEMIOLOGY
Newburger JW, Takahashi M, Gerber MA, et al: Diagnosis, treatment, and long-term management of Kawasaki disease. Pediatrics 2004;114:1708–1733.Nelson Textbook of Pediatrics 19th Edition
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Average: 408 cases/year
M:F Ratio – 1.6:1
Age distribution:
28 days-1 year – 20-25%1-4 years old – 50%
Philippine Pediatric Society – May 2006- December 2008 (2.5 years)
EPIDEMIOLOGY
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Discussion
Clinical and epidemiologic features suggests an INFECTIOUS cause
Hypothesis:1.Infectious cause manifesting in genetically predisposed individuals2.Bacterial superantigenic toxin3.Antigen driven4.immune response to different microbial agents
PATHOGENESIS
Newburger JW, Takahashi M, Gerber MA, et al: Diagnosis, treatment, and long-term management of Kawasaki disease. Pediatrics 2004;114:1708–1733.
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Discussion
Acute or Subacute stages Edema of endothelial and smooth muscle cells Inflammatory infiltration of the vascular wall
– polymorphonuclear cells – Macrophages– lymphocytes (primarily CD8 T cells)– plasma cells IgA plasma cells - prominent in the
inflammatory infiltrate
PATHOGENESIS
Nelson Textbook of Pediatrics 18th Edition
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Discussion
In Severely affected vessels:
Inflammation of 3 layers of the vascular
wall
Destruction of the internal elastic lamina
Vessels weaken
Aneurysm formation
Thrombi
Blood Flow Obstruction
PATHOGENESIS
Nelson Textbook of Pediatrics 18th Edition
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Healing Phase
Fibrotic vascular wall
Stenotic occlusion of the vessel
PATHOGENESIS
Nelson Textbook of Pediatrics 18th Edition
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Acute Kawasaki disease- an inflammatory infiltrate present in certain nonvascular tissues host immune response
MyocardiumUpper respiratory tractPancreasKidneyBiliary tract
PATHOGENESIS
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Fever of at least 5 days duration plus 4 0f 5 criteria plus lack of another known disease process to explain the illness
Current Opinion in Infectious Diseases 2008, 21:263–270
CLINICAL FEATURES
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Bilateral conjunctival injection – 85%
Current Opinion in Infectious Diseases 2008, 21:263–270
CRITERIA
Changes of the mucous membranes of the upper respiratory tract: injected, fissured lips;
strawberry tongue – 90%
Polymorphous rash - 80%Changes of the extremities: peripheral edema, peripheral erythema, and periungual desquamation – 75%
Cervical adenopathy – 40%
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I. Acute Febrile Phase
II. Subacute Phase
III. Convalescent Phase
PHASES
Nelson Textbook of Pediatrics 19th Edition
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I. Acute Febrile Phase High grade Fever Irritable Bilateral conjunctivitis and rash Erythema and edema of hands and feet Red and cracked tongue and oral
mucosa Cardiac complications: myocarditis and
pericarditisParillo, Steven J., DO, FACOEP, FACEP. Pediatric Kawasaki Disease Follow-up.
emedicine.medscape.com/article/804960-followup#showall. March 18, 2010
PHASES
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II. Subacute Phase Fever and other signs have abated End by the 4th week persistent irritability Anorexia Conjunctival injection Risk of cardiac complications Thrombocytosis develops Desquamation of the fingertips and toes Aneurysm formation Greatest risk of sudden death
PHASES
Parillo, Steven J., DO, FACOEP, FACEP. Pediatric Kawasaki Disease Follow-up. emedicine.medscape.com/article/804960-followup#showall. March 18, 2010
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III. Convalescent Phase begins when all signs of illness
have disappeared ESR and CRP level return to normal presence of coronary artery
aneurysms
PHASES
Parillo, Steven J., DO, FACOEP, FACEP. Pediatric Kawasaki Disease Follow-up. emedicine.medscape.com/article/804960-followup#showall. March 18, 2010
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IV. Chronic Phase For patients who have cardiac
complications
PHASES
Parillo, Steven J., DO, FACOEP, FACEP. Pediatric Kawasaki Disease Follow-up. emedicine.medscape.com/article/804960-followup#showall. March 18, 2010
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Cardiovascular findingsMusculoskeletal SystemGastrointestinal Tract
Central Nervous SystemGenitourinary System
Nelson Textbook of Pediatrics 18th Edition
CLINICAL FINDINGS
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Primary Laboratory Findings - markers of systemic inflammation
1. ESR > 40 mm/hr
2. CRP > 3 mg/dl
Echocardiogram - recommended for all patients who meet 1 or both of these criteria
Newburger JW, Takahashi M, Gerber MA, et al: Diagnosis, treatment, and long-term management of Kawasaki disease. Pediatrics 2004;114:1708–1733.
LABORATORY FINDINGS
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Supplemental Laboratory Findings:
1. Albumin < 3 g/ d2. Anemia for age3. Increased alanine aminotransferase
(ALT)4. Platelet count > 450 X 103 /µl after
7 days of fever5. WBC > 15 X 103 / µL6. Urine WBC > 10/hpf
Newburger JW, Takahashi M, Gerber MA, et al: Diagnosis, treatment, and long-term management of Kawasaki disease. Pediatrics 2004;114:1708–1733.
LABORATORY FINDINGS
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A patient who meets ≥ 3 supplementary criteria qualifies
for treatment
Treatment may precede performance of echocardiogram
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Newburger JW, Takahashi M, Gerber MA, et al: Diagnosis, treatment, and long-term management of Kawasaki
disease. Pediatrics 2004;114:1708–1733.
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2. Aspirin Anti-inflammatory dose in acute phase: 80-100 mg/kg/day given every 6 hours
Antiplatelet / anti-thrombotic dose:3-5 mg/kg/day single dose, 2-3 days
after the fever lyses; given for 6 weeks and continued indefinitely if coronary abnormalities are observed
TREATMENT
Scheinfeld, Noah S. MD, JD, FAAD, et. al. Intravenous Immunoglobulin.emedicine.medscape.com/article/210367-overview#aw2aab6b7. May 9, 2011.
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3. Heparin/ Warfarin- anticoagulants
4. Corticosteroids
Others: Pentoxyfylline, Ulinastatin, Abciximab
TREATMENT
Scheinfeld, Noah S. MD, JD, FAAD, et. al. Intravenous Immunoglobulin.emedicine.medscape.com/article/210367-overview#aw2aab6b7. May 9, 2011.
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Risk Level Pharmacological Therapy
Physical Activity
Follow-up and Diagnostic
Testing
Invasive Testing
I. No coronaryartery changesat any stagesof illness
II. Transientcoronary arteryEctasisDisappearswithin 1st 6-8wks
III. 1 smallmediumcoronary arteryaneurysm/majorcoronary artery
None beyond 1st 6-8 wks
None beyond 1st 6-8 wks
Low dose aspirin (3-5 mkD), at least until aneurysm regression documented
No restrictions beyond 1st 6-8 wks
No restrictions beyond 1st 6-8 wks
Pt <11 yo, no restriction beyond 1st 6-8 wksPt 11-20yo,P.A guided by biennal stress test, evaluation of myocardial perfusion scan
Cardiovascular risk assesment, counseling at 5 yr intervals
Cardiovascular risk assesment, counseling at 3 to 5 yr intervals
Annual cardiology follow-up with echocardiogram +ECG, combined with cardiovascular risk assesment, counseling; biennal stress test,eval.myocardial perfusion scan
None recommended
None recommended
Angiography, if noninvasive test suggest ischemia
Newburger et al. Diagnosis, treatment and long-term management of KD. American Academy of Pediatrics.2004
RISK Level INo coronaryArtery changesat any stagesof illness
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Risk Level Pharmacological Therapy
Physical Activity
Follow-up and Diagnostic
Testing
Invasive Testing
I. No coronaryartery changesat any stagesof illness
II. Transientcoronary arteryEctasisDisappearswithin 1st 6-8wks
III. 1 smallmediumcoronary arteryaneurysm/majorcoronary artery
None beyond 1st 6-8 wks
None beyond 1st 6-8 wks
Low dose aspirin (3-5 mkD), at least until aneurysm regression documented
No restrictions beyond 1st 6-8 wks
No restrictions beyond 1st 6-8 wks
Pt <11 yo, no restriction beyond 1st 6-8 wksPt 11-20yo,P.A guided by biennal stress test, evaluation of myocardial perfusion scan
Cardiovascular risk assesment, counseling at 5 yr intervals
Cardiovascular risk assesment, counseling at 3 to 5 yr intervals
Annual cardiology follow-up with echocardiogram +ECG, combined with cardiovascular risk assesment, counseling; biennal stress test,eval.myocardial perfusion scan
None recommended
None recommended
Angiography, if noninvasive test suggest ischemia
RISK Level IITransientcoronary arteryEctasia disappearswithin 1st 6- 8wks
Newburger et al. Diagnosis, treatment and long-term management of KD. American Academy of Pediatrics.2004
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Risk Level Pharmacological Therapy
Physical Activity
Follow-up and Diagnostic
Testing
Invasive Testing
I. No coronaryartery changesat any stagesof illness
II. Transientcoronary arteryEctasisDisappearswithin 1st 6-8wks
III. 1 smallmediumcoronary arteryaneurysm/majorcoronary artery
None beyond 1st 6-8 wks
None beyond 1st 6-8 wks
Low dose aspirin (3-5 mkD), at least until aneurysm regression documented
No restrictions beyond 1st 6-8 wks
No restrictions beyond 1st 6-8 wks
Pt <11 yo, no restriction beyond 1st 6-8 wksPt 11-20yo,P.A guided by biennal stress test, evaluation of myocardial perfusion scan
Cardiovascular risk assesment, counseling at 5 yr intervals
Cardiovascular risk assesment, counseling at 3 to 5 yr intervals
Annual cardiology follow-up with echocardiogram +ECG, combined with cardiovascular risk assesment, counseling; biennal stress test,eval.myocardial perfusion scan
None recommended
None recommended
Angiography, if noninvasive test suggest ischemia
RISK Level III1 small mediumcoronary arteryaneurysm/majorcoronary artery
Newburger et al. Diagnosis, treatment and long-term management of KD. American Academy of Pediatrics.2004
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Risk Level Pharmacological Therapy
Physical Activity Follow-up and Diagnostic
Testing
Invasive Testing
IV. ≥ 1 large orgiant coronaryartery aneuryms,or multiple orcomplexaneuryms insame coronaryartery, withoutobstruction
V. Coronaryarteryobstruction
Long-term antiplatelet therapy and warfarin or low molecular-weight heparin, should be combine in giant aneurysm
Long-term low-dose aspirin; warfarin or low-molecular-weight heparin if giant aneurysm persists ; consider use of β
Contact or high impact sports should be avoided because of risk of bleeding; other physical activity recommendations guided by stress test/evaluation of myocardial perfusion scan outcome
Contact or high impact sports should be avoided because of risk of bleeding; other physical activity recommendations guided by stress test/myocardial perfusion scan outcome
Biannual follow up with echocardiogram +ECG; annual stress test/evaluation of myocardial perfusion scan
Biannual follow-up with echocardiogram and ECG; annual stress test/evaluation of myocardial perfusion scan
1st angiography at 6-12 mo or sooner if clinically indicated; repeated angiography if noninvasive test, clinical or laboratory findings suggest ischemia;elective repeat angiography
Angiography recommended to address therapeutic options
RISK Level IV ≥ 1 large or giant coronaryartery aneuryms, or multiple or
complex aneuryms insame coronary artery, without
obstruction
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Risk Level Pharmacological Therapy
Physical Activity Follow-up and Diagnostic
Testing
Invasive Testing
IV. ≥ 1 large orgiant coronaryartery aneuryms,or multiple orcomplexaneuryms insame coronaryartery, withoutobstruction
V. Coronaryarteryobstruction
Long-term antiplatelet therapy and warfarin or low molecular-weight heparin, should be combine in giant aneurysm
Long-term low-dose aspirin; warfarin or low-molecular-weight heparin if giant aneurysm persists ; consider use of β
Contact or high impact sports should be avoided because of risk of bleeding; other physical activity recommendations guided by stress test/evaluation of myocardial perfusion scan outcome
Contact or high impact sports should be avoided because of risk of bleeding; other physical activity recommendations guided by stress test/myocardial perfusion scan outcome
Biannual follow up with echocardiogram +ECG; annual stress test/evaluation of myocardial perfusion scan
Biannual follow-up with echocardiogram and ECG; annual stress test/evaluation of myocardial perfusion scan
1st angiography at 6-12 mo or sooner if clinically indicated; repeated angiography if noninvasive test, clinical or laboratory findings suggest ischemia;elective repeat angiography
Angiography recommended to address therapeutic options
RISK Level V Coronary artery obstruction
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Myocardial Infarction
Development and Rupture of Coronary artery aneurysms
American Heart Association, 2001
COMPLICATIONS
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Depends on : Severity of coronary artery involvement as a
risk for myocardial ischemia
Without proper treatment of IVIG: Risk to develop abnormalities in coronary
arteries is 20-25%
With proper treatment of IVIG : Risk to develop abnormalities in their
coronary arteries is 2-4%
American Heart Association, 2001
PROGNOSIS
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In general, the risk of death from cardiac complications is about 1% to 2% most commonly during the first 2-12 weeks of illness
American Heart Association, 2001
PROGNOSIS
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