Katalog kurser på forskarnivå VT12 - kiwas.ki.sekiwas.ki.se/kicoursecatalogueVT12.pdfDesign of...

Katalog kurser på forskarnivå

VT12

# Sjukdomslära * Allmänvetenskap Laboratory Animal Science 2012-03-12 -- 2012-03-31 (Engelska)1131 Laboratory Animal Science 2012-01-23 -- 2012-02-11 (Engelska)1131 Transcultural Mental Health - screening, intervention and evaluation 2012-05-21 -- 2012-05-25 (Engelska)1257 Cellular Signalling 2012-03-05 -- 2012-03-09 (Engelska)1280 Basic Course in Medical Statistics * 2012-05-14 -- 2012-05-25 (Engelska)1383 Basic Course in Medical Statistics * 2012-02-20 -- 2012-03-02 (Engelska)1383 Basic Course in Medical Statistics * 2012-03-19 -- 2012-03-30 (Engelska)1383 Basic Course in Medical Statistics * 2012-04-16 -- 2012-04-27 (Engelska)1383 Medicinsk vetenskapsteori och forskningsetik * 2012-02-20 -- 2012-02-24 (Svenska)1386 Philosophy of science and research ethics * 2012-05-07 -- 2012-05-11 (Engelska)1386 Medicinsk vetenskapsteori och forskningsetik * 2012-04-16 -- 2012-04-20 (Svenska)1386 Philosophy of science and research ethics * 2012-03-12 -- 2012-03-16 (Engelska)1386 Writing science and information literacy * 2012-05-21 -- 2012-06-01 (Engelska)1391 Vetenskapligt skrivande och informationskompetens * 2012-04-16 -- 2012-04-27 (Svenska)1392 Introductory course in SAS programming 2012-05-07 -- 2012-05-11 (Engelska)1447 Infections in the Tropics 2012-03-12 -- 2012-04-13 (Engelska)1472 Biostatistics II: Logistic regression for epidemiologists * 2012-01-30 -- 2012-02-07 (Engelska)1513 Experimental techniques in study of metabolic and endocrine disorders 2012-03-05 -- 2012-03-09 (Engelska)1559 Health risk assessment I: principles and applications 2012-03-26 -- 2012-03-30 (Engelska)1561 Epidemiology I: Introduction to epidemiology 2012-05-22 -- 2012-06-12 (Engelska)1577 Alzheimer's Disease: Clinical Features and Pathogenic Mechanisms 2012-02-06 -- 2012-02-10 (Engelska)1584 Epidemiology II. Design of epidemiological studies 2012-02-13 -- 2012-02-22 (Engelska)1622 Endothelial function and its relevance in cardiovascular disease 2012-05-07 -- 2012-05-11 (Engelska)1710 Cellular Imaging and Confocal Techniques 2012-05-21 -- 2012-06-01 (Engelska)1725 Pain mechanisms: From molecules to treatment 2012-06-11 -- 2012-06-15 (Engelska)1727 Cellular Imaging and Confocal Techniques - Theory 2012-05-21 -- 2012-05-25 (Engelska)1735 Studiedesign vid klinisk forskning 2012-03-02 -- 2012-04-27 (Svenska)1794 Datainsamling- och dataanalys I: Introduktion till kvalitativa metoder 2012-02-21 -- 2012-04-18 (Svenska)1816 Introduktion till test-teori och analys av kliniska test och enkäter 2012-03-05 -- 2012-03-29 (Svenska)1817 Interview techniques in health and care research 2012-01-17 -- 2012-02-15 (Engelska)1818 Introduction to multivariate data analysis 2012-04-23 -- 2012-05-09 (Engelska)1819 Global Malaria Eradication 2012-02-13 -- 2012-02-17 (Engelska)1823 Clinical Immunology in Infectious Diseases 2012-05-21 -- 2012-06-01 (Engelska)1832 Pathogen-Host Interactions Research Seminar Series 2012-01-25 -- 2012-05-16 (Engelska)1877 Biostatistics IV: Applied Longitudinal Data Analysis 2012-04-17 -- 2012-04-25 (Engelska)1895 Surgical techniques in rat and mouse 2012-06-08 -- 2012-06-15 (Engelska)1978 How to write a scientific paper - and get published * 2012-03-12 -- 2012-03-16 (Engelska)1988 How to write a scientific paper - and get published * 2012-05-07 -- 2012-05-11 (Engelska)1988 Advanced seminars in Tumor Biology 2012-01-10 -- 2012-06-19 (Engelska)2000 What is life? The future of biology. 2012-01-25 -- 2012-06-13 (Engelska)2001 Pathology # 2012-05-21 -- 2012-06-01 (Engelska)2044 GRUNDLÄGGANDE BIOSTATISTIK OCH EPIDEMIOLOGI * 2012-03-12 -- 2012-03-16 (Svenska)2045 GRUNDLÄGGANDE BIOSTATISTIK OCH EPIDEMIOLOGI * 2012-04-16 -- 2012-04-20 (Svenska)2045 Frontiers in leadership research 2012-02-14 -- 2012-05-08 (Engelska)2068 Qualitative Research Methods 2012-04-10 -- 2012-04-27 (Engelska)2076 Forskningsetik * 2012-01-24 -- 2012-02-14 (Svenska)2132 Vetenskapsteori * 2012-02-28 -- 2012-05-08 (Svenska)2133 To communicate science in different contexts * 2012-02-21 -- 2012-03-21 (Engelska)2144 Att kommunicera vetenskap i olika sammanhang * 2012-04-17 -- 2012-05-23 (Svenska)2144 From Science to Business -- Concepts in Biotechnology 2012-03-29 -- 2012-05-24 (Engelska)2159 Genetics of complex diseases 2012-04-16 -- 2012-04-27 (Engelska)2161 Exploring human movement with computerised movement analysis systems 2012-03-08 -- 2012-04-20 (Engelska)2194 Social kompetens: Presentationsteknik, samarbete och relationsbyggande * 2012-04-16 -- 2012-04-27 (Svenska)2198 Social skills: Presentation techniques, cooperation and relationships * 2012-03-26 -- 2012-03-30 (Engelska)2198 Basic Laboratory Safety * 2012-03-19 -- 2012-03-23 (Engelska)2211 Human embryonic stem cells 2012-05-21 -- 2012-05-25 (Engelska)2212 Redox regulation, oxidative stress and selenoproteins 2012-06-11 -- 2012-06-15 (Engelska)2214 Modern methods for DNA sequencing. 2012-03-12 -- 2012-03-16 (Engelska)2218 Bioinformatics for cell biologists * 2012-05-21 -- 2012-05-25 (Engelska)2219 Management and research 2012-02-09 -- 2012-06-07 (Engelska)2234 Scientifically evaluated interventions in suicide prevention 2012-05-07 -- 2012-05-11 (Engelska)2236 Statistical modeling and inference using likelihood 2012-02-06 -- 2012-06-15 (Engelska)2261 The Yin and Yan of endocytosis in health and disease 2012-04-19 -- 2012-04-25 (Engelska)2271

The Yin and Yan of endocytosis in health and disease 2012-04-19 -- 2012-04-25 (Engelska)2271 Basic immunology 2012-02-07 -- 2012-03-08 (Engelska)2302 Functional Fluorescence Microscopy Imaging (fFMI) in biomedical research 2012-05-21 -- 2012-06-01 (Engelska)2348 Observation och video som forskningsmetod inom vårdområdet 2012-01-25 -- 2012-03-27 (Svenska)2350 Positron emission tomography imaging of the CNS 2012-03-12 -- 2012-03-16 (Engelska)2362 Antigen presentation and T cell activation 2012-03-05 -- 2012-03-09 (Engelska)2363 Practical Proteomics 2012-04-02 -- 2012-04-13 (Engelska)2371 The symbiotic concept: autoimmunity and tumorimmunity 2012-03-12 -- 2012-03-16 (Engelska)2373 Communication - retorics, dialogue, memory technique and group dynamics 2012-05-21 -- 2012-06-01 (Engelska)2374 Biology of Inflammation 2012-01-13 -- 2012-06-08 (Engelska)2388 Aktuell Omvårdnadsvetenskap - teori och praxis 2012-02-02 -- 2012-03-09 (Svenska)2407 Gene Expression Analysis 2012-05-07 -- 2012-05-11 (Engelska)2409 Communicate your research! - A crash course in science communication * 2012-03-26 -- 2012-03-28 (Engelska)2415 Causal Inference for Epidemiological Research 2012-02-13 -- 2012-02-22 (Engelska)2416 Principles of nucleic acid structure 2012-01-23 -- 2012-02-23 (Engelska)2430 Career skills for scientists 2012-02-01 -- 2012-03-07 (Engelska)2463 Calcium signaling 2012-04-30 -- 2012-05-11 (Engelska)2464 PASW I (SPSS) - datahantering för att beskriva dina data 2012-02-15 -- 2012-02-17 (Svenska)2475 Methods and ethics in research with children 2012-02-20 -- 2012-02-24 (Engelska)2476 Manuscript writing * 2012-07-02 -- 2012-07-06 (Engelska)2490 Analysis of cancer with the next generation of high through put technologies 2012-04-16 -- 2012-04-20 (Engelska)2493 Basics of Qualitative research 2012-03-26 -- 2012-03-30 (Engelska)2518 Research documentation: theory and real examples * 2012-02-13 -- 2012-02-17 (Engelska)2521 Research documentation: theory and real examples * 2012-05-07 -- 2012-05-11 (Engelska)2521 Computational neuroscience and Neuroinformatics 2012-04-23 -- 2012-05-04 (Engelska)2534 Brain Imaging: Measurement of Brain Morphology using Magnetic Resonance Images 2012-03-19 -- 2012-03-23 (Engelska)2552 Writing Science and Information Literacy * 2012-02-06 -- 2012-03-30 (Engelska)2561 Electron tomography -reconstruction and image processing with IMOD 2012-01-23 -- 2012-01-27 (Engelska)2563 Functional regulation in development and disease 2012-02-27 -- 2012-03-02 (Engelska)2565 Developmental and Pediatric Endocrinology 2012-03-19 -- 2012-03-23 (Engelska)2566 Basic principles in molecular imaging for medical diagnostics through magnetic resonance physics 2012-04-16 -- 2012-04-272568

(Engelska) Introduction to R statistical analysis for biologists 2012-02-13 -- 2012-02-17 (Engelska)2570 Psykoneuroimmunologi 2012-03-19 -- 2012-05-25 (Svenska)2571 Microdosimetry - a course on principles and applications in radiation dosimetry biophysics and medical physics. 2012-06-04 --2572

2012-06-30 (Engelska) In vivo imaging of tissue transplanted into the anterior chamber of the eye. 2012-02-13 -- 2012-02-24 (Engelska)2573 Advanced diagnostic methods for hearing impaired children 2012-06-04 -- 2012-08-31 (Engelska)2574 Transplantation immunology 2012-05-07 -- 2012-05-11 (Engelska)2575 Cochlear Implants 2012-01-23 -- 2012-06-08 (Engelska)2579 Non-coding RNA and cancer 2012-05-14 -- 2012-05-18 (Engelska)2583

Title : Laboratory Animal Science

1131Kursnummer : 4.5Antal högskolepoäng :

2012-03-12 -- 2012-03-31Datum : EngelskaSpråk :

ForskarnivåNivå : Comparative medicineKursansvarig institution :

Särskild behörighet : After the course, the student will possess the following qualifications 1.Humane use of animals. Know how toKursens lärandemål :

handle laboratory animals in a humane manner. 2.The Swedish law and required permissions. Knows the legal requirements inSweden for conducting animal experiments. Knows where and how to apply for required permissions. Capable to translate legal andethical requirements into the practical design of new animal experiments. 3.Housing and breeding of laboratory animals. Candiscuss laboratory environments vs. animal quality of life and hygienic needs. Handles both wild type and genetically modifiedanimals effectively and safely. Can explain how animal nutrition may impact on research results. 4. Laboratory animal diseases andhealth risks. Knows microbes and parasites that commonly infect laboratory animals. Can explain how these may impact onexperimental results. Can demonstrate how common health risks and preventable adverse events in laboratory animals can beminimised. 5. Practice. Can handle laboratory animals appropriately with respect to species differences. Can identify and applyappropriate methods for experimental treatment, such as administration of analgesia or anaesthesia, surgery including perioperativecare, and euthanasia. 6. Alternative methods, species selection, and power calculations. Can systematically explore and evaluateanimal free research methods. Can appropriately select animal species, where needed for new research activities. Can calculate thestatistical power of a study and minimal sample size to minimise the use of animals. Complies with good laboratory practice (GLP)requirements where needed.

The course contents are in accordance with recommendations from the Federation of European LaboratoryKursens innehåll : Animal Science Associations (FELASA) and with the European legislation. Contents include introduction to laboratory animalscience, design of animal experiments, legislation, laboratory animal genetics, behaviour, stress and homeostasis, allergies andother health hazards, gnotobiology, nutrition, animal welfare, environment and experimental procedures, transgenic technologies,alternatives to animal use, good laboratory practice, Diseases of laboratory animals, preventions of infections, anaesthesia, surgery,euthanasia, ethics, animal protection. Demonstrations/laboratory sessions (in smaller groups): Techniques for handling and restraint,injection, sampling and anaesthesia (rabbit, rat, mouse). Additionally, students will prepare an experimental protocol and analyse ascientific paper. A written examination is included.

Lectures, group assignments and laboratory practice.Arbetsformer : Written exam and group assignments Examination :

All practical sessions, all group works and some of the lectures are cumpulsory. Missed parts can beObligatoriska moment : completed after agreement with Veterinary Resources.

30 - 80Antal studenter : Registered doctoral students at KI and at other Swedish Universities have priority. Do not forget to give theUrval av studenter :

date of your registration as a doctoral student. Only complete applications with full contact details as name, group leader/supervisor,department address, e-mail and telephone number, will be considered. We do not consider applications from PharmaceuticalCompanies or Universities outside Sweden.

It is important to know that the course is full time studies Monday to Friday from 8 am to 5 pm under aYtterligare information : three weeks period. Location at KI Campus Solna. The course is accredited at a C level by the Federation of Laboratory AnimalScience Association (FELASA). Leading International specialists such as Prof Jann Hau, Vera Baumans, René Remie and RicardoFeinstein will lectures within their fields. The course has both theoretical and practical moments. All moments are mandatory. Theofficial course language is English. Please observe that examination takes place on a saturday.

Kursansvarig : Dude GigliottiKomparativ [email protected]

Berzelius väg 13

171 77STOCKHOLM

Kontaktpersoner : Dude GigliottiKomparativ [email protected]

Berzelius väg 13

171 77

STOCKHOLM

Title : Laboratory Animal Science



ForskarnivåNivå : Comparative medicineKursansvarig institution :

Särskild behörighet : After the course, the student will possess the following qualifications 1.Humane use of animals. Know how toKursens lärandemål :

handle laboratory animals in a humane manner. 2.The Swedish law and required permissions. Knows the legal requirements inSweden for conducting animal experiments. Knows where and how to apply for required permissions. Capable to translate legal andethical requirements into the practical design of new animal experiments. 3.Housing and breeding of laboratory animals. Candiscuss laboratory environments vs. animal quality of life and hygienic needs. Handles both wild type and genetically modifiedanimals effectively and safely. Can explain how animal nutrition may impact on research results. 4. Laboratory animal diseases andhealth risks. Knows microbes and parasites that commonly infect laboratory animals. Can explain how these may impact onexperimental results. Can demonstrate how common health risks and preventable adverse events in laboratory animals can beminimised. 5. Practice. Can handle laboratory animals appropriately with respect to species differences. Can identify and applyappropriate methods for experimental treatment, such as administration of analgesia or anaesthesia, surgery including perioperativecare, and euthanasia. 6. Alternative methods, species selection, and power calculations. Can systematically explore and evaluateanimal free research methods. Can appropriately select animal species, where needed for new research activities. Can calculate thestatistical power of a study and minimal sample size to minimise the use of animals. Complies with good laboratory practice (GLP)requirements where needed.

The course contents are in accordance with recommendations from the Federation of European LaboratoryKursens innehåll : Animal Science Associations (FELASA) and with the European legislation. Contents include introduction to laboratory animalscience, design of animal experiments, legislation, laboratory animal genetics, behaviour, stress and homeostasis, allergies andother health hazards, gnotobiology, nutrition, animal welfare, environment and experimental procedures, transgenic technologies,alternatives to animal use, good laboratory practice, Diseases of laboratory animals, preventions of infections, anaesthesia, surgery,euthanasia, ethics, animal protection. Demonstrations/laboratory sessions (in smaller groups): Techniques for handling and restraint,injection, sampling and anaesthesia (rabbit, rat, mouse). Additionally, students will prepare an experimental protocol and analyse ascientific paper. A written examination is included.

Lectures, group assignments and laboratory practice.Arbetsformer : Written exam and group assignments Examination :

All practical sessions, all group works and some of the lectures are cumpulsory. Missed parts can beObligatoriska moment : completed after agreement with Veterinary Resources.

10 - 30Antal studenter : Registered doctoral students at KI and at other Swedish Universities have priority. Do not forget to give theUrval av studenter :

date of your registration as a doctoral student. Only complete applications with full contact details as name, group leader/supervisor,department address, e-mail and telephone number, will be considered. We suggest that applicants apply for both, January andMarch 2012 courses. We do not consider applications from Pharmaceutical Companies or Universities outside Sweden.

It is important to know that the course is full time studies Monday to Friday from 8 am to 5 pm under aYtterligare information : three weeks period. Location at KI Campus Solna. The course is accredited at a C level by the Federation of Laboratory AnimalScience Association (FELASA). Leading International specialists such as Prof Jann Hau, Vera Baumans, René Remie and RicardoFeinstein will lectures within their fields. The course has both theoretical and practical moments. All moments are mandatory. Theofficial course language is English. Please observe that examination takes place on a saturday.

Kursansvarig : Dude GigliottiKomparativ [email protected]

Berzelius väg 13

171 77STOCKHOLM


Berzelius väg 13

171 77

STOCKHOLM

Title : Transcultural Mental Health - screening, intervention and evaluation



ForskarnivåNivå : Department of Neurobiology, Care Sciences and SocietyKursansvarig institution :

Särskild behörighet : At the end of the module students will be able to: - identify transcultural mental health key concepts - discussKursens lärandemål :

transcultural research methods, some basic and relevant research obstacles, ethical issues, and factors determining the variationsin mental health among different immigrant groups - assess methods for transcultural mental health and mental health promotionsstrategies - reflect about own values and norms in research questions, methods, and outcomes and evalutation

Review relevant research literature. Some basic and relevant research obstacles, paradigms, ethical issues andKursens innehåll : questions in transcultural mental health research. An overview of different qualitative research methods, validity, trustworthiness,tranferability and implications of contextualized findings, an explorative case. Physiological, psychosocial and diagnosticmeasurement of mental health assessment among refugee groups, prospective design. How to perform a survey based on register:Migration, access to employment and mental health Circumstances of and treatment and other services provided for patients withmental illness in a multicultural area, skills in using traditional and internet tools in collecting data

The course will consist of 1 week, fulltime, and 1 week of reading material before the start. Leaning activities includeArbetsformer : lectures, group work, video-conference lecture and discussion, individual assignments and and interactive seminars

Individual project/thesis description, title and study area; study design and methods. Oral presentation of group workExamination : It is compulsory to attend all the lectures. Absence will be compensated for by extra individualObligatoriska moment :

assignments provided by the course organizers10 - 20Antal studenter :

Students will be selected based on: 1. Written motivation 2. Date of registration as a doctoral student. Urval av studenter : Ytterligare information :

Kursansvarig : Solvig EkbladInstitutionen för lärande, informatik, management och [email protected]

Berzelius väg 3, plan 4

171 77Stockholm

Kontaktpersoner : Anna SillenInstitutionen för neurobiologi, vårdvetenskap och samhälle08-524 868 [email protected]

Title : Cellular Signalling



ForskarnivåNivå : Department of Laboratory MedicineKursansvarig institution :

Särskild behörighet : Kursen syftar till att ge en bred teoretisk kunskap med forskningsinriktad vetenskap inom området cellulärKursens lärandemål :

signalering samt väcka intresse för signaleringsvägar i normala och defekta eller sjuka vävnader. Efter genomförd kurs skallstudenten: - kunna grundläggande teoretiska kunskaper inom cellulär signaleringsområdet. - få vetenska om nya moderna metoder,som används inom forskningsområdet. - kunna redogöra muntlig en kortfattad vetenskaplig rapport inom visst forskningsprojekt somkritiskt granskas. - kunna använda kunskap för sin egen forskningsprojekt.Kursens innehåll :

Föreläsningar, presentationer och grupp diskussioner. Arbetsformer : Muntlig presentationExamination :

Närvaron på alla seminarier är obligatorisk, frånvaro kompenseras med en skriftlig resumé. Obligatoriska moment : 15 - 30Antal studenter :

Selection will be based on 1. Date of registration as doctoral student 2. Clinical project which will have benefitUrval av studenter : from the course. 3. A very short motivation, on how the course will contribute positively for the research project.

Date and Time: Week 10 (Monday until Friday), from 9:00 AM until 15:00 PM Examination: OralYtterligare information : presentations Presentations: All Lectures are compelsary Contant of the course: An over view ..... Domains and modules in signaltransduction, Beston Nore (LabMed, KI) Insulin signalling: Implemented model in signal transduction, Anna Krook (FyFa, KI) Antigenreceptor signaling, Edvard Smith (LabMed, KI) Protein tyrosine kinase receptors, Johan Lennartsson (Ludwig Inst., Uppsala) Signaling of Innate Immune Recepetors, Steve Applequist (CIM, KI) G-protein coupled receptors, Gunnar Schulter (FyFa, KI) Frizzled Signaling, Gunnar Schulte (FyFa, KI) Cytokine receptor signalling, Lars-Arne Haldosén (BioNut, KI) Cell cycle andapoptosis, Klas Wiman (CCK, KI) Intracellular signalling of phosphorylated inositols, Chris Barker (MolMed, KI) Proteomic tools todissect TGFb signalling, Serhiy Souchelnytski (Biomics, KI) Sonic hedehog signalling pathways, Stephan Teglund (BioNut, KI) Nuclear Receptor Signalling, Eckardt Treuter (BioNut, KI) The role of ubiquitination in cellular signalling, Kristina Lindsten (CMB, KI) Protein serine/threonine kinase receptors and smad signalling, Aristidis Moustakas (Ludwig Inst., Uppsala) Signaling through smallGTPases, Pontus Aspenström (MTC, KI) Cell-matrix adhesion complexes as a signaling hub, Staffan Strömblad (BioNut, KI) Geneknockout strategies in signal transduction (BioNut, KI) Assignments in Signal Transduction (Oral Presentation for examination)

Kursansvarig : Beston NoreInstitutionen för [email protected]

Hälsovägen 7-9Clinical Research Center, KFC-Novum14186Stockholm

Kontaktpersoner : Hanna ErikssonInstitutionen för [email protected]

Edvard SmithInstitutionen för laboratoriemedicin

[email protected]

Title : Basic Course in Medical Statistics



ForskarnivåNivå : Department of Learning, Informatics, Management and EthicsKursansvarig institution :

Särskild behörighet : The course participants shall after the course be able to perform basic summaries, analyses andKursens lärandemål :

presentation of data, as well as have enhanced their ability to recognise, understand and critically view the statistics being presentedin medical articles.

The course is an introduction to basic statistical principles and how statistics play a part in medical research.Kursens innehåll : Concepts being treated are hypothesis, type I error, type II error, estimate, measurement of dispersion, regression analysis,inference making and how to present the results.

Classroom course: The course will consist of four scheduled half or whole days per week for two weeks. LecturesArbetsformer : will be mixed with seminars, where the course participants have group discussions, and manual exercises. Distance course: Thefirst and last day of the course will be face-to-face. The course will be a distance course by using the platform Pingpong. The rest ofthe time will be spent working on computer based homework and reading the course literature.

Course requirements: - Correct answers on the computer based exercises. - Active participation in the manualExamination : calculations. - Active participation in the seminars.

Attendance is mandatory for the manual exercises and the seminars. If the student is absent, he or sheObligatoriska moment : can compenste the absence by handing in written answers to questions concerning the compulsory moments.

35 - 40Antal studenter : The selection for this general basic science course will be based on (1) your ranking of the applied course andUrval av studenter :

(2) your registration date as a PhD student at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KI in your personal profile and that you have ranked the courses you have applied for. Please observe:To this course you have to reply by December the 4th 2011 at the latest after getting a preliminary acceptance offer.

This is a distance course. Type of teaching: The first and last day of the course will be face-to-face. TheYtterligare information : course will be a distance course by using the platform Pingpong where videolectures will be available and the platform KIDU for theexercises.

Kursansvarig : Mesfin TessmaInstitutionen för lärande, informatik, management och etik

[email protected]

Kontaktpersoner : Margareta Krook-BrandtInstitutionen för lärande, informatik, management och [email protected]















[email protected]














The course will consist of four scheduled half or whole days per week for two weeks. Course dates: 19/3 -Ytterligare information : 20/3, 22/3 - 23/3, 26/3 - 27/3, 29/3 - 30/3; 2012


[email protected]
















[email protected]


Title : Medicinsk vetenskapsteori och forskningsetik


2012-02-20 -- 2012-02-24Datum : SvenskaSpråk :


NejSärskild behörighet : Doktoranden ska kunna presentera och sätta sin egen forskning i ett vetenskapsteoretisk och forskningsetiskKursens lärandemål :

sammanhang och kunna problematisera den i relation till vetenskapliga normer för vad som är normalvetenskap, vetenskapligargumentation och god forskningssed. Ska också kunna problematisera vad som förstås vid ett vetenskapligt faktum, veta skillnadenmellan vetande och kunnande, hur vetenskapen kan utveckla sig, synen på falibilism samt den historiska utvecklingen av detinformerade samtycket och Helsingforsdeklarationerna, etikprövningsnämndernas verksamhet och bedömningsgrunder.

Följande rubriker illustrerar innehållet i kursen: Vad förstås vid ett vetenskapligt paradigm? Vad förstås vid ettKursens innehåll : vetenskapligt faktum? Är observation en teorifri aktivitet? Varifrån kommer hypoteser? Hur ser vetenskaplig argumentation ut? Ärvetenskaplig forskning värderingsfri? Har försökspersoner en moralisk skyldighet att ställa upp i klinisk forskning? Vad är villkoren föratt vi får bedriva forskning med människor och djur? Hur kan vi rättfärdiga användningen av djur i medicinsk forskning med avsiktenatt göra gott och inte skada människor?

Introducerande föreläsningar, grupparbeten och plenumdiskussioner.Arbetsformer : Deltagarna skriver en egen vetenskapsteoretisk eller forskningsetisk reflektion över sitt eget forskningsprojekt.Examination :

Vid frånvaro krävs särskilt utförliga svar på de fall som diskuterats. Gruppdiskussionerna ochObligatoriska moment : plenumdiskussionerna är obligatoriska.

25 - 30Antal studenter : Urvalet till denna allmänvetenskapliga baskurs baseras på (1) din rangordning av den sökta kursen och (2) detUrval av studenter :

datum som du registrerades som doktorand vid Karolinska Institutet. Var vänlig se till att du lagt in korrekt registreringsdatum när duregistrerades som doktorand i din personliga profil, samt att du rangordnat kurserna du sökt. Var vänlig observera: Till denna kursmåste du svara senast den 4 december 2011 när du har fått ett preliminärt antagningsbesked.

Berzelius väg 3, plan 4, Solna. Ytterligare information :

Kursansvarig : Niels LynoeInstitutionen för lärande, informatik, management och etik

[email protected]

Kontaktpersoner : -

Title : Philosophy of science and research ethics




NoSärskild behörighet : The doctoral students is supposed to be capable to present his/her own research within the framework ofKursens lärandemål :

philosophy of science and research ethics and able to debate it in relation to scientific norms on what is understood as normalscience, scientific argumentation and good research practice. The doctoral student is also supposed to question what is understoodas a scientific fact, acknowledge the difference between knowing how and knowing that, how science develop, the current view onfallibilism as well as the historical development of informed consent and the Helsinki Declarations, the research ethics committeesand their ethical and legal framework.

The subsequent headings illustrate the course contents: What is a scientific paradigm? What is a scientific fact?Kursens innehåll : Is observation a theory free activity? Where does the hypothesis come from? How does scientific argumentation look like? Is thescientific enterprise value-free? Do patients and research persons have moral duties to participate in clinical research? What are theconditions for human beings and animals to participate in medical research? How do we justify the use of animals for the benefit ofmankind?

Introducing lectures, group work and general discussions.Arbetsformer : - The doctoral students write a short informal essay on a scientific or research ethical theme related to their ownExamination :

research. - Attendance is mandatory for the group work and general discussions. - If the student is absent, he or sheObligatoriska moment :

can compenste by handling in written answers concerning the cases that have been discussed.25 - 30Antal studenter :

The selection for this general basic science course will be based on (1) your ranking of the applied course andUrval av studenter : (2) your registration date as a PhD student at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KIin your personal profile and that you have ranked the courses you have applied for. Please observe:To this course you have to reply by December the 4th 2011 at the latest after getting a preliminary acceptance offer. Ytterligare information :


[email protected]

Kontaktpersoner : Emma KarlssonInstitutionen för lärande, informatik, management och etik08-524 83 [email protected]

Title : Medicinsk vetenskapsteori och forskningsetik




NejSärskild behörighet : Doktoranden ska kunna presentera och sätta sin egen forskning i ett vetenskapsteoretisk och forskningsetiskKursens lärandemål :

sammanhang och kunna problematisera den i relation till vetenskapliga normer för vad som är normalvetenskap, vetenskapligargumentation och god forskningssed. Ska också kunna problematisera vad som förstås vid ett vetenskapligt faktum, veta skillnadenmellan vetande och kunnande, hur vetenskapen kan utveckla sig, synen på falibilism samt den historiska utvecklingen av detinformerade samtycket och Helsingforsdeklarationerna, etikprövningsnämndernas verksamhet och bedömningsgrunder.

Följande rubriker illustrerar innehållet i kursen: Vad förstås vid ett vetenskapligt paradigm? Vad förstås vid ettKursens innehåll : vetenskapligt faktum? Är observation en teorifri aktivitet? Varifrån kommer hypoteser? Hur ser vetenskaplig argumentation ut? Ärvetenskaplig forskning värderingsfri? Har försökspersoner en moralisk skyldighet att ställa upp i klinisk forskning? Vad är villkoren föratt vi får bedriva forskning med människor och djur? Hur kan vi rättfärdiga användningen av djur i medicinsk forskning med avsiktenatt göra gott och inte skada människor?

Introducerande föreläsningar, grupparbeten och plenumdiskussioner.Arbetsformer : Deltagarna skriver en egen vetenskapsteoretisk eller forskningsetisk reflektion över sitt eget forskningsprojekt.Examination :

Vid frånvaro krävs särskilt utförliga svar på de fall som diskuterats. Gruppdiskussionerna ochObligatoriska moment : plenumdiskussionerna är obligatoriska.


datum som du registrerades som doktorand vid Karolinska Institutet. Var vänlig se till att du lagt in korrekt registreringsdatum när duregistrerades som doktorand i din personliga profil, samt att du rangordnat kurserna du sökt. Var vänlig observera: Till denna kursmåste du svara senast den 4 december 2011 när du har fått ett preliminärt antagningsbesked. Ytterligare information :


[email protected]


Title : Philosophy of science and research ethics




NoSärskild behörighet : The PhD students is supposed to be capable to present his/her own research within the framework ofKursens lärandemål :

philosophy of science and research ethics and able to debate it in relation to scientific norms on what is understood as normalscience, scientific argumentation and good research practice. The PhD student is also supposed to question what is understood asa scientific fact, acknowledge the difference between knowing how and knowing that, how science develop, the current view onfallibilism as well as the historical development of informed consent and the Helsinki Declarations, the research ethics committeesand their ethical and legal framework.

The subsequent headings illustrate the course contents: What is a scientific paradigm? What is a scientific fact?Kursens innehåll : Is observation a theory free activity? Where does the hypothesis come from? How does scientific argumentation look like? Is thescientific enterprise value-free? Do patients and research persons have moral duties to participate in clinical research? What are theconditions for human beings and animals to participate in medical research? How do we justify the use of animals for the benefit ofmankind?

Introducing lectures, group work and general discussions.Arbetsformer : - The PhD students write a short informal essay on a scientific or research ethical theme related to their ownExamination :

research. - Attendance is mandatory for the group work and general discussions. - If the student is absent, he or sheObligatoriska moment :

can compenste by handling in written answers concerning the cases that have been discussed.25 - 30Antal studenter :

The selection for this general basic science course will be based on (1) your ranking of the applied course andUrval av studenter : (2) your registration date as a PhD student at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KIin your personal profile and that you have ranked the courses you have applied for. Please observe:To this course you have to reply by December the 4th 2011 at the latest after getting a preliminary acceptance offer. Ytterligare information :


[email protected]


Title : Writing science and information literacy



ForskarnivåNivå : Karolinska Institutet University LibraryKursansvarig institution :

Särskild behörighet : After the course, you should: - be able to organize, write and revise a research report based on own data -Kursens lärandemål :

know how applications are evaluated and have some idea about what makes applications successful - have practiced writing aboutresearch for a general audience - be able to recognize and correct common structural and stylistic writing weaknesses - be aware ofethical considerations in connection with the writing process - know how to submit a paper and understand the scientificcommunication system - be able to analyze scientific problems from an information needs perspective - be able to apply theprinciples of medical information retrieval - know about medical sciences databases and other information resources - be able toretrieve, evaluate and cite the medical sciences literature - understand what Open Access implies

Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structureKursens innehåll : and style, Ethical issues in writing, Publication process, Principles of medical information retrieval, Getting started with referencemanagement -- Endnote, Tips and tricks with Word, Literature evaluation tools for the medical sciences, Open Access

Individual writing and rewriting, lectures, working in pairs and groups, web-based teaching, demonstrations,Arbetsformer : computer exercises and individual study

Writing a grant application with popular science summary and rewriting (including references) based on peer andExamination : teacher feedback

The course writing assignment is obligatory and has to be submitted about 10 days BEFORE course start.Obligatoriska moment : All scheduled teaching is complusory (except where clearly stated otherwise). Absence can be compensated for by reading andindividual work after consultation with course leaders.


(2) your registration date as a PhD student at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KIin your personal profile and that you have ranked the courses you have applied for. Please observe:To this course you have to reply by December the 4th 2011 at the latest after getting a preliminary acceptance offer. Ytterligare information :

Kursansvarig : david herronKarolinska Institutet [email protected]

Berzelius 7B

17177Stockholm

Kontaktpersoner : -

Title : Vetenskapligt skrivande och informationskompetens




Särskild behörighet : Efter kursen ska du: - kunna organisera, skriva och revidera en forskningsrapport baserad på egna data -Kursens lärandemål :

känna till hur ansökningar utvärderas och några av framgångsfaktorerna - ha prövat att skriva populärvetenskapligt - känna igenoch kunna korrigera de vanligaste strukturella och stilistiska svagheterna i text - vara medveten om etiska överväganden vidvetenskapligt skrivande - känna till ansökningsförfarandet och det vetenskapliga publiceringssystemet - kunna analyseravetenskapliga frågeställningar ur ett informationsperspektiv - kunna tillämpa principer för medicinsk databassökning - känna till ettantal biomedicinska databaser och andra informationsresurser - kunna söka, värdera och citera medicinsk vetenskaplig information - förstå vad Open Access innebär

Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structureKursens innehåll : and style, Ethical issues in writing, Publication process, Principer för medicinsk databassökning, Introduktion till referenshantering --Endnote, Tips och råd i Word, Evalueringsverktyg för medicinsk vetenskap, Open Access.

Individuella skrivuppgifter och revision, föreläsningar, par- och grupparbeten, webbaserat lärande, demonstrationer,Arbetsformer : datorövningar och individuella studier. Obs. kursdelen som behandlar vetenskapligt skrivande hålls på engelska

Skrivande av en anslagsansökan (på engelska) med populärvetenskaplig sammanfattning (på svenska) samtExamination : bearbetning (med referenser) baserat på "peer"- och lärarkommentarer.

Skrivuppgiften är obligatorisk och måste inlämnas cirka 10 dagar FÖRE kursens början. Obligatoriska moment : 30 - 34Antal studenter :

Urvalet till denna allmänvetenskapliga baskurs baseras på (1) din rangordning av den sökta kursen och (2) detUrval av studenter : datum som du registrerades som doktorand vid Karolinska Institutet. Var vänlig se till att du lagt in korrekt registreringsdatum när duregistrerades som doktorand i din personliga profil, samt att du rangordnat kurserna du sökt. Var vänlig observera: Till denna kursmåste du svara senast den 4 december 2011 när du har fått ett preliminärt antagningsbesked.Ytterligare information :


Berzelius 7B

17177Stockholm

Kontaktpersoner : david herronKarolinska Institutet [email protected]

Berzelius 7B

17177Stockholm

Title : Introductory course in SAS programming



ForskarnivåNivå : Department of Public Health SciencesKursansvarig institution :

Basic computer skillsSärskild behörighet : After successfully completing this course you as a student are expected to be able to: - apply the SASKursens lärandemål :

system when importing and exporting data. - manipulate data using SAS labels and formats. - manipulate data using SAS functionsand programming statements. - perform descriptive statistics using adequate SAS procedures. - describe how to use the SAS helpmanual (SAS OnlineDoc).

The course is designed to give fundamental insights in the SAS system and basic skills in the SAS programmingKursens innehåll : language. The course embraces commands for definition, description, modification, selection and analysing of data, and covers: -Introduction to the SAS Windows - SAS data sets, creating, importing and exporting data - Data handling, programming statementsand SAS functions - SAS procedures for descriptive statistics

Full-time in supervised computer lab with a mixture of interactive lectures and excercises. Every morning a quiz,Arbetsformer : recapitulating the previous days' lectures.

To pass the course, the student has to show that the learning outcomes have been achieved. The course will endExamination : with an examination consisting of both an individually written and individually computerized exam where the covered commands areused. Students who do not obtain a passing grade in the first examination will be offered a second chance to resubmit theexamination within two months of the final day of the course. Students who do not obtain a passing grade at the first twoexaminations will be given top priority for admission the next time the course is offered.

Only the examination is compulsory. Obligatoriska moment : 12 - 22Antal studenter :

1. Registered doctoral students from KI 2. Registered doctoral students from outside KI 3. Others Within eachUrval av studenter : category, students will be prioritised according to the relevance of the course content for their research. To be considered, studentsare advised to submit a completed application form. Please, give all information requested, including a motivation why applying forthe course as well as a description of current research and previous courses taken.

Basic computer skills are required. Ytterligare information :

Kursansvarig : Jette MöllerInstitutionen för folkhä[email protected]

Kontaktpersoner : Jette MöllerInstitutionen för folkhä[email protected]

Title : Infections in the Tropics



ForskarnivåNivå : Department of Medicine, SolnaKursansvarig institution :

Särskild behörighet : To understand and be made familiar with the conditions under which the major infectious diseases in theKursens lärandemål :

Tropics arise and how they are prevented/treated locally. To be acquaited with the conditions for biomedical research in the Tropicsand be exposed to some of the current local research issues.

Field studies under local and Swedish supervision at the primary,secondary och tertiary health care level. JointKursens innehåll : seminars (mutual presentations of research projects ) at local research institute. Formulation and presentation at the end of thecourse of elective projects.

Bedside and benchside teachings at hospitals and polyclinics/health care centers. Seminars. Elective works.Arbetsformer : Presentation of elective projects to local and Swedish faculty. Oral exam possibly on patients/samplesExamination :

Obligatoriska moment : 7 - 12Antal studenter :

Doctoral students with an interest of infectious diseases and international medicine.Urval av studenter : Time: 1/Five seminar sessions between 1700-1830 Feb/March on the major tropical infection, internationalYtterligare information :

health and the culture/geography of the country (Ethiopia or Ghana) for the field study. Venue; Dept Infect Dis,KS. 2/ A field coursein Ethiopia or Ghana ( to be decided later) March10-April 1st,2012 3/ Reports on elective projects and exam April10-13,2012 (week1).Easter week free for prepararation of elective projects. Venue; Dept Infect Dis,KS Lay-out; Part one; brief theoretical exposure ofthe major Tropical infections and identification of elective projects Part two; Visits to primary, secondary and tertiary healthinstitutions of host country (Ethiopia or Ghana) under guidance of local staff and faculty together with the course organizer(SB).Clinical rounds, night duty attendance, mother and child health care center attendance, vaccine campaigns. Work on electiveprojects. A joint Seminar time with Ph students in Ethiopia/Ghana where paticipants and local students, respectively present anddiscuss their projects together with local supervisors and course organizer(SB) Part three; Reporting of elective projects ( groups of1 or two students). Oral exam. Costs; A fee for contribution to expences of full board accommodation and local transport will berequested against receipt whereas all other expences including international flights will be covered. Course organizer; Sven Britton,professor of Infectious Diseases. Information; [email protected]. tel 0736870738.

Kursansvarig : Sven BrittonInstitutionen för medicin, [email protected]

Kontaktpersoner : Sven BrittonInstitutionen för medicin, [email protected]

Title : Biostatistics II: Logistic regression for epidemiologists



ForskarnivåNivå : Department of Medical Epidemiology and BiostatisticsKursansvarig institution :

Knowledge in epidemiology and biostatistics equivalent to "Epidemiology I: Introduction to epidemiology" andSärskild behörighet : "Biostatistics I: Introduction for epidemiologists" or corresponding courses.

After successfully completing this course you as a student are expected to be able to: - choose a suitableKursens lärandemål : regression model for assessing a specific research hypothesis using data collected from an epidemiological study, fit the modelusing standard statistical software, evaluate the fit of the model, and interpret the results. - explain the concept of confounding inepidemiological studies and demonstrate how to controll/adjust for confounding using statistical models. - apply and interpretappropriate statistical models for studying effect modification. - critically evaluate the methodological aspects (design and analysis)of a scientific article reporting an epidemiological study. Learning outcomes are classified according to Bloom´s taxonomy:knowledge, comprehension, application, analysis, synthesis, and evaluation.

This course focuses on the application of logistic regression in the analysis of epidemiological studies. TopicsKursens innehåll : covered include a brief introduction to categorical data analysis, simple logistic regression, interpretation of parameters forcontinuous and categorical predictors, multivariate logistic regression, confounding and interaction, model fitting and modeldiagnostics, conditional logistic regression. Multinomial and ordinal logistic regression will be outlined.

Lectures, computer lab with exercises focusing on analysis of real data sets using statistical software, exercises notArbetsformer : requiring statistical software, group discussions, literature review.

To pass the course, the student has to show that the learning outcomes have been achieved. The course grade isExamination : based solely on a written examination. The focus of the exam will be on understanding concepts and their application to analysis ofepidemiological studies rather than mathematical detail. The course examination will be held within one week of the final day of thecourse. Students who do not obtain a passing grade in the first examination will be offered a second examination within two monthsof the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority foradmission the next time the course is offered. If the course is not offered during the following two academic terms then a thirdexamination will be scheduled within 12 months of the final day of the course.

Only the examination is compulsory. Obligatoriska moment : 12 - 25Antal studenter :

Prior knowledge equivalent to Epidemiology I and Biostatistics I or corresponding courses. Eligible doctoralUrval av studenter : students will be prioritized according to 1) the relevance of the course for their research , and 2) the stated motivation for attendingthe course. To be considered, submit a completed application form and give all information requested including a short description ofcurrent research and motivation for attending, as well as an account of previous courses taken.

The course is extended over 2 weeks (but still 5 course days) to promote reflection and active learning.Ytterligare information : Course participants are expected to attend class at Karolinska Institutet Campus Solna each course day (January 30, February 1, 3,6, and 7).

Kursansvarig : Rino BelloccoInstitutionen för medicinsk epidemiologi och [email protected]

Brännkyrkagatan 45

11822Stockholm

Kontaktpersoner : Kerstin MothanderInstitutionen för medicinsk epidemiologi och [email protected]

Title : Experimental techniques in study of metabolic and endocrine disorders



ForskarnivåNivå : Department of Molecular Medicine and SurgeryKursansvarig institution :

Särskild behörighet : After the course the students will be able i) to measure glucose transport in isolated rodent skeletal muscle;Kursens lärandemål :

ii) to measure lipolysis in isolated adipocytes; iii) to dissect out mouse pancreatic islets and measure the insulin release; iv) to judgeand analyze obtained data. The students will learn possibilities and limitations of the described above techniques.

The aim of this course is to provide methodology to solve pre-clinical problems in metabolic and endocrineKursens innehåll : research. The course is laboratory based, aiming to give all participants hands on experience with isolation of pancreatic islets,skeletal muscle and adipose tissue. Theoretical and practical considerations will be presented and discussed.

The course meets for five days full time, including three full day laboratory practical sessions. The first day willArbetsformer : consist of several lectures to give a background to the metabolic questions which will be addressed in the practical part of thecourse. Our aim is to provide the student with a hands on experience of each technique covered. In order to achieve this, for thelaboratory work the course participants will be subdivided into smaller groups.

The laboratory notebook examination, a short oral presentation of the project work.Examination : All three laboratory tasks are compulsory; as an exception, a written task could be given to a participant toObligatoriska moment :

compensate absence.6 - 18Antal studenter :

Students will be prioritised according to the relevance of the course content for their research and on theirUrval av studenter : motivation.

The course will start March 5, 2012 at 8:45, KI Solna Campus. Thereafter students will be divided intoYtterligare information : three groups. Each group will be working with three different experimental techniques from Tuesday until Thursday. See the locationbelow: Skeletal muscle; Alexander Chibalin, Ph.D. Lubna Al-Khalili, Ph.D. at KI, Solna Campus. Beta cell biology; Neil Portwood,Ph.D. at Karolinska University Hospital Solna. Adipose biology; Jurga Laurencikiene, Ph.D. at Karolinska University HospitalHuddinge.

Kursansvarig : Lubna KhaliliInstitutionen för molekylär medicin och [email protected]

von Eulersväg 4aintegrative physiology17177Stockholm

Kontaktpersoner : Alexander ChibalinInstitutionen för molekylär medicin och [email protected]

Lubna KhaliliInstitutionen för molekylär medicin och [email protected]

von Eulersväg 4aintegrative physiology17177Stockholm

Title : Health risk assessment I: principles and applications



ForskarnivåNivå : Institute of Environmental MedicineKursansvarig institution :

Särskild behörighet : After the course the student shall have aquired knowledge and understanding of the methods andKursens lärandemål :

procedures used in health risk assessment. The student shall also have aquired a professional attitude in interpretation oftoxicological and epidemiological studies for use in health risk assessment.

The course will include fundamental concepts in toxicology and risk assessment, epidemiology, exposureKursens innehåll : assessment, and will also cover risk assessment in regulatory decision-making, critical effects, extrapolation, uncertainty factors andallocation of health-based guidance values. Furthermore, attention will be paid to interpretation possibilities and evaluation of datafrom different test systems, handling of uncertainties and data gaps, and other problems in health risk assessment. Specificproblems created by carcinogens and other types of chemicals will also be discussed.

The course consists mainly of lectures, but also includes group work that are presented orally and discussed.Arbetsformer : The examination is the presentation and discussion of group work. If necessary this is complemented by oralExamination :

questioning (for individual examination).Participation in the group work is compulsory. Absence can be compensated with an individual task.Obligatoriska moment :

5 - 20Antal studenter : The selection of students is based on the relevance of previous training and experience as well as on theUrval av studenter :

individual motivation. The course is one-week, full-time. It is held at the Institute of Environmental Medicine, Nobels väg 13, KIYtterligare information :

Campus Solna.

Kursansvarig : Annika HanbergInstitutet för miljö[email protected]

Kontaktpersoner : Anna MarcusInstitutet för miljö[email protected]

Title : Epidemiology I: Introduction to epidemiology




Särskild behörighet : After successfully completing this course students are expected to be able to: -give examples of theKursens lärandemål :

contribution of epidemiology to science and discuss the importance of epidemiology as a research discipline. -estimate and in ageneral way interpret measures of disease occurrence and measures of association, and describe how a specific measure isgoverned by the study design. -explain strengths and weaknesses of common epidemiological study designs. -identify and explainpossible sources of bias in epidemiological studies. -describe theoretical models for causation and discuss the principles of causalmechanisms. -apply knowledge of epidemiological concepts when critically reviewing scientific literature. Learning outcomes areclassified according to Bloom´s taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation.

The course gives an introduction to epidemiological theory and practice. It comprises basic principles regardingKursens innehåll : design, interpretation, and analysis of epidemiological studies. It introduces the concept of causation, concepts related to measuresof disease occurrence and measures of association, common designs for epidemiological studies (with main focus on cohortstudies), and the role of bias.

The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon theArbetsformer : knowledge, rather than memorising facts. Different strategies for teaching and learning will be used, such as lectures, groupdiscussions and various forms of group exercises on selected topics.

To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methodsExamination : used are group assignments along with written and oral individual tasks. The examination is viewed as contributing to thedevelopment of knowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examinationwill be offered a second chance to resubmit the examination within two months of the final day of the course. Students who do notobtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered.

The examination tasks are compulsory. Obligatoriska moment : 12 - 25Antal studenter :

Eligible registered doctoral students will be prioritized according to 1) the relevance of the course content forUrval av studenter : their research, and 2) the stated motivation for attending the course. To be considered, please submit a completed application formand give all information requested, including a description of current research and motivation for attending, as well as an account ofprevious courses taken.

This time, the course is given with a Blended learning design, meaning a mix of traditional learningYtterligare information : activities in the classroom and computer mediated learning activities carried out outside the classroom. Course participants areexpected to attend class (at Campus Solna) on May 22 and May 30. At these occasions there will be traditional lectures as well asgroup sessions where participants will work together solving different tasks. The remaining learning activities during May 22 to June12 will consist of web based assignments, mainly in groups but also individually. The main tool for the web based learning will be thePingPong-platform.

Kursansvarig : Anita BerglundInstitutet för miljömedicin

[email protected]

Kontaktpersoner : Karin LeanderInstitutet för miljö[email protected]

Box 210 (Nobels väg 13), KI

171 77Stockholm

Title : Alzheimer's Disease: Clinical Features and Pathogenic Mechanisms




Särskild behörighet : After the course the student will have acquired up-to-date knowledge of different aspects of Alzheimer'sKursens lärandemål :

disease from clinical symptoms and diagnosis to molecular mechanisms and future perspectivesThis course provides up-to-date knowledge of different aspects of Alzheimer's disease (AD) from clinicalKursens innehåll :

symptoms and diagnosis to molecular mechanisms and future therapeutics.The pedagocic framing is based on lectures by invited Swedish and international scientist that will cover the topicsArbetsformer :

of clinical signs and symptoms, diagnosis, pathology, epidemiology, genetics, molecular mechanisms, animals models, therapeuticstrategies. Group work, preparation of seminars and presentation of group work.

Group examination of the topics by an examinator.Examination : Both Lectures and the Group work are compulsory. Absence from any of these should be compensated forObligatoriska moment :

by essay(s) on the topic(s) missed in agreement with the course director.10 - 40Antal studenter :

Doctoral students working on Alzheimer's disease or other neurodegenerative disorders will be prioritizedUrval av studenter : according to theirs motivation.

Monday-Friday from 9:00 - 16:00Ytterligare information :

Kursansvarig : Eirikur BenedikzInstitutionen för neurobiologi, vårdvetenskap och samhälle

[email protected]

Kontaktpersoner : -

Title : Epidemiology II. Design of epidemiological studies




Knowledge in epidemiology equivalent to "Epidemiology I: Introduction to epidemiology" or correspondingSärskild behörighet : courses.

After successfully completing this course you as a student are expected to be able to: - in a self-directedKursens lärandemål : manner, formulate the principles of different types of common epidemiological study designs. - mainly independently, explain how aspecific measure of disease occurrence and measure of association is governed by the study design. - in a self-directed manner,explain and discuss epidemiological concepts, including accuracy, in the context of different epidemiological study designs. - drawconclusions from epidemiological scientific papers and to review and criticize these regarding study design, results and accuracy.Learning outcomes are classified according to Bloom's taxonomy: knowledge, comprehension, application, analysis, synthesis, andevaluation.

The course focus on issues related to study design (primarily case-control methodology), study base, studyKursens innehåll : efficiency, matching in epidemiological studies, induction time, interpretation of epidemiologic evidence.

Lectures, group discussions and various forms of group exercises on selected topics, will be used. The courseArbetsformer : focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorisingfacts.

To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methodsExamination : used are group tasks along with written and oral individual tasks.The examination is viewed as a contributing to the development ofknowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examination will be offered asecond examination within two months of the final day of the course. Students who do not obtain a passing grade at the first twoexaminations will be given top priority for admission the next time the course is offered.

Only the examination tasks are compulsory.Obligatoriska moment : 12 - 25Antal studenter :

Previous knowledge equivalent to Epidemiology I: Introduction to epidemiology or corresponding courses. Urval av studenter : Eligible doctoral students will be prioritized according to 1) the relevance of the course for their research, and 2) the statedmotivation for attending the course. To be considered, please submit a completed application form and give all informationrequested including a short description of current research and motivation for attending, as well as an account of previous coursestaken.

The course is extended over 2 weeks (but still 5 course days) to promote reflection and active learning.Ytterligare information : Course participants are expected to attend class at Karolinska Institutet Campus Solna each course day 9.00-16.00 (February 13,15, 17, and 20 and 22). The learning activities within the course will consist of lectures, group sessions as well as individualassignments to be performed at home.

Kursansvarig : Lars AlfredssonInstitutet för miljömedicin

[email protected]

Kontaktpersoner : Anita BerglundInstitutet för miljömedicin

[email protected]

Title : Endothelial function and its relevance in cardiovascular disease




Särskild behörighet : After the course, the students should have acquired fundamental molecular and cellular biology ofKursens lärandemål :

endothelial cell, and shall be able to relate their own research projects to the cutting-edge developments in cardiovascular research. The course will cover the following topics: endothelial cell produced vasoactive substances, endothelial cells inKursens innehåll :

immune and inflammatory response, molecular control of angiogenesis, endothelial progenitor cell, cardiovascular risk factors andendothelial dysfunction, endothelial cell phenotype, signaling of intercellular junctions.

The course will consist of lectures and seminars given by experts in the respective fields. The course also involvesArbetsformer : group work, literature studies and oral presentation.

Final examination is based on the group work. The students will be assigned with research subjects/scientificExamination : questions related to topics of the course, and required to give an oral presentation and a brief written summary reflecting the subjectof the group work.

Lectures, project work and presentation of project are compulsory. Missed lectures and seminars can beObligatoriska moment : compensated by other activities after discussion with the course leader.

12 - 20Antal studenter : 1. Short written motivation 2. Date of registration.Urval av studenter :

May 7-10. lectures, group discussions; May 11. group presentation. The course will be held at CMM,Ytterligare information : Karolinska University Hospital, Solna. Lectures will be given in English by renowned scientists and clinicians in the field ofcardiovascular research.

Kursansvarig : Zhong-Qun YanInstitutionen för medicin, [email protected]

CMM L8:03, Karolinska Hospital

17176Stockholm

Kontaktpersoner : Anders GabrielsenInstitutionen för medicin, Solna

[email protected]

Ann HellstromInstitutionen för medicin, Solna

[email protected]

Title : Cellular Imaging and Confocal Techniques



ForskarnivåNivå : Department of NeuroscienceKursansvarig institution :

Särskild behörighet : Knowledge and understanding: After completion of the course, the graduate student should be able to 1)Kursens lärandemål :

account for the different microscopy techniques which are being used for imaging of different types of cells and their properties, 2)account for the theoretical bases of different imaging techniques, 3) describe the principles to follow in selecting the suitable imagingtechnique for a particular scientific problem. Skills: The graduate student should be able to 1) describe the principles of operation ofdifferent microscopy systems, 2) independently select and apply a suitable imaging technique for a particular preparation, 3)describe the principles to follow in optimization and problem-solving in the use of different imaging techniques. Professionalattitudes: The graduate student should be able to 1) evaluate the suitability of different imaging techniques for different types ofpreparations and scientific problems, 2) evaluate how different imaging techniques have been utilized in scientific articles, 3) criticallyconsider pros and cons of different imaging techniques, 4) summarize and communicate his/her knowledge and understanding toother users of different microscopy systems.

Different methods for microscopic imaging, with an emphasis on fluorescence and confocal techniques, will beKursens innehåll : considered in detail. Techniques for imaging of fixed preparations, as well as live cell imaging of dynamic processes, will also becovered.

The course duration is two weeks. First week (full-time, scheduled): Morning lectures (4 hours/day); afternoons -Arbetsformer : project work in groups with practical exercises and demonstrations on different imaging systems (4 hours/day; 4-5 systems to beused in parallel), seminars. Second week: Group work with project compilation and presentations.

Group presentations of project work; individual, written exam.Examination : The compulsory parts of the course are the practical exercises and project presentations, and a writtenObligatoriska moment :

exam. To compensate for absence from a compulsory part the graduate student will have the opportunity to complement the projectwork, and to write an extra exam.

15 - 25Antal studenter : The primary selection criteria are 1) the usefulness of the course for the doctoral student in his/her researchUrval av studenter :

project, and 2) the motivation given in the application to the course.This course is directed towards doctoral students that work with, or plan to work with projects involvingYtterligare information :

cellular imaging techniques, including confocal microscopy. The course aims at providing a thorough and up-to-date theoreticalbackground as well as practical experience of confocal and other imaging techniques. The course duration is two weeks. First week(full-time, scheduled): Morning lectures (4 hours/day); afternoons - project work in groups with practical exercises anddemonstrations on different imaging systems (4 hours/day; 4-5 systems to be used in parallel), seminars. Second week: Group workwith project compilation and presentations. Lectures and seminars: Large Seminar Room (A2 319), MBB, KI, Campus Solna.

Kursansvarig : Peter WallénInstitutionen för [email protected]

Retzius väg 8, A3-5

171 77Stockholm

Kontaktpersoner : Per UhlenInstitutionen för medicinsk biokemi och [email protected]

Title : Pain mechanisms: From molecules to treatment



ForskarnivåNivå : Department of Physiology and PharmacologyKursansvarig institution :

-Särskild behörighet : - Identify the major anatomical structures associated with pain transmission from the peripheral through theKursens lärandemål :

central nervous system. - Identify the fundamental biological structural components and pathways of pain signaling from a cellularperspective and outline the pain signals propagation by neural transmission from where it originates in the periphery through thesynaptic networks of the central nervous system. - Describe systems and mechanisms that either facilitate or inhibit paintransmission in either the peripheral or central nervous system. - Describe current knowledge on gender- or sex-based differences inpain signaling or perception in animals and man. - Categorize the diversity of common pain conditions in patients in terms ofpresentation, etiology, and proposed neurobiological mechanisms and treatment. - Contrast pre-clinical and clinical models of paintransmission and analgesia. - Discuss the evaluation and statistical analysis of preclinical and clinical pain data. - Summarize thecurrent pharmacological approaches used for pain management and describe putative peripheral and central targets for newanalgesic drugs. - Discuss the several non-pharmacological, complementary and alternative techniques that are applied for painmanagement. - Discuss the opportunities offered for the future by broad spectrum gene and protein array approaches, functionalimaging etc for the study of pain and analgesia.

Basic Science Nociceptors, nociception and pain Mediators, receptors, ion channels and intracellular signaling.Kursens innehåll : Dorsal horn structure and function. Ascending nociceptive pathways. Descending inhibition and facilitation. Peripheral and centralsensitization. Neuroimmune interactions in chronic pain. Role of glial activation in pain. Genetics of pain and species and sexdifferences in anatomy, molecular biology and behavior. Genomics and pain. Proteomics and pain. Assessment of pain andnociception, neuroimaging and statistical analysis Overview of clinical pain testing. Placebo and nocebo. Sensory assessment inanimals. Neuroimaging and pain. Statistical analysis of preclinical and clinical pain data. Chronic pain in the clinic and animalmodels. Clinical states with inflammatory pain. Animal models of acute and chronic inflammatory pain. Neuropathic pain in the clinic.Animal models of neuropathic pain. Musculoskeletal pain, fibromyalgia. Cancer pain: causes, consequences and Therapeuticopportunities. Animal models of cancer pain. Visceral pain. Headache, migraine, whiplash pain. Treatment of pain Mechanisms ofaction of established analgesic drugs and targets for new analgesic drugs. Clinical pharmacology of analgesic drugs. Surgicalapproaches in pain management and CNS stimulation for neuropathic, ischemic and visceral pain. Psychotherapeutic approaches totreat chronic pain. Complementary and alternative therapies for chronic pain.

Lectures, seminars, round table discussions, laboratory demonstrations, clinical demonstrationsArbetsformer : The examination for all students will consist of some multiple choice questions from each teacher. In addition, essaysExamination :

and/or project presentations and discussions for all students will be included. -Obligatoriska moment :

15 - 50Antal studenter : Those with a PhD project involving pain research will be prioritized.Urval av studenter :

This course is co-directed by Karolinska Institutet and the University of Minnesota in Minneapolis, USAYtterligare information : and is taught by a team of more than 20 internationally recognized experts. The course takes place at KI Campus Solna during oneweek with lectures or demos/lab excercises both before and after the lunch breaks (08:00-17:30).

Kursansvarig : Ernst BrodinInstitutionen för Fysiologi och Farmakologi

[email protected]

Kontaktpersoner : Camilla SvenssonInstitutionen för Fysiologi och Farmakologi

[email protected]

Title : Cellular Imaging and Confocal Techniques - Theory




-Särskild behörighet : Knowledge and understanding: After completion of the course, the graduate student should be able to 1)Kursens lärandemål :

account for the different microscopy techniques which are being used for imaging of different types of cells and their properties, 2)account for the theoretical bases of different imaging techniques, 3) describe the principles to follow in selecting the suitable imagingtechnique for a particular scientific problem. Skills: The graduate student should be able to 1) describe the principles of operation ofdifferent microscopy systems, 2) describe the principles to follow in optimization and problem-solving in the use of different imagingtechniques. Professional attitudes: The graduate student should be able to 1) evaluate the suitability of different imaging techniquesfor different types of preparations and scientific problems, 2) evaluate how different imaging techniques have been utilized inscientific articles, 3) critically consider pros and cons of different imaging techniques, 4) summarize and communicate his/herknowledge and understanding to other users of different microscopy systems.

Different methods for microscopic imaging, with an emphasis on fluorescence and confocal techniques, will beKursens innehåll : considered in detail. Techniques for imaging of fixed preparations, as well as live cell imaging of dynamic processes, will also becovered.

The course duration is one week (full-time, scheduled): Morning lectures (4 hours/day); afternoons - individualArbetsformer : studies. One full day: Demonstrations of different imaging systems.

Individual, written exam.Examination : The compulsory part of the course is a written exam. To compensate for absence the graduate student willObligatoriska moment :

have the opportunity to write an extra exam.15 - 25Antal studenter :

The primary selection criteria are 1) the usefulness of the course for the graduate student in his/her graduateUrval av studenter : work, and 2) the motivation given in the application to the course.

This course is directed towards graduate students that work with, or plan to work with projects involvingYtterligare information : cellular imaging techniques, including confocal microscopy. The course aims at providing a thorough and up-to-date theoreticalbackground of confocal and other imaging techniques. The course duration is one week (full-time, scheduled): Morning lectures (4hours/day); afternoons - individual studies. One full day: Demonstrations of different imaging systems. Lectures and seminars: LargeSeminar Room (A2 319), MBB, KI, Campus Solna.

Kursansvarig : Peter WallénInstitutionen för [email protected]

Retzius väg 8, A3-5

171 77Stockholm

Kontaktpersoner : Per UhlenInstitutionen för medicinsk biokemi och [email protected]

Title : Studiedesign vid klinisk forskning




-Särskild behörighet : Efter kursen ska kursdeltagaren kunna: 1) beskriva och tillämpa grundläggande begrepp inomKursens lärandemål :

klinisk/epidemiologisk forskning. 2) beskriva och förklara de viktigaste felkällorna och kausalitetsbegreppet. 3) argumentera för såvälfördelar som nackdelar med olika studiedesigner på ett vetenskapligt konstruktivt sätt. 4) reflektera över bästa möjliga studiedesignvid planering av en vetenskaplig studie.

Följande innehåll presenteras: 1) Introduktion till grundläggande begrepp, 2) Mått på sjukdomsförekomst ochKursens innehåll : mått på samband/effekt, 3) Observationella studier; kohort/fall-kontrollstudier, 4) Systematiska fel, slumpmässiga fel och kausalitet,5) Experimentella studier; randomiserade kliniska prövningar och sensitivitet/specificitet, 6) Livskvalitet i klinisk forskning, 7) Muntligexamination och kursutvärdering. En stor del av kursen ägnas åt ett omfattande projektarbete (examinationsuppgift 1): ¿Att designasin egen studie¿. Examinationsuppgift 2 innebär aktivt deltagande vid granskning av vetenskapliga artiklar. Kursen riktar sig tillforskarstuderande med intresse för klinisk/epidemiologisk forskning i allmänhet och till kliniskt verksamma forskarstuderande isynnerhet. Det är en fördel att gå kursen tidigt under forskarutbildningen.

Kursen fokuserar på ett individuell projektarbete där kursdeltagaren ska utarbeta ett välskrivet protokoll för enArbetsformer : planerad vetenskaplig studie. Under kursens gång ges föreläsningar och handledning till stöd för kursdeltagaren vid det individuellaprojektarbetet samt artikelgranskningarna. Föreläsningarna blandas med diskussioner och peer feedback ingår i det individuellaprojektarbetet.

För att bli godkänd på kursen måste studenten aktivt delta i examinationsformerna: 1) Skriftlig och muntligExamination : presentation och argumentation avseende ett individuellt projektarbete med syfte att komma fram till bästa möjliga studiedesignsamt kritisk granskning och diskussion av andra deltagares projektarbeten. 2) Kritisk granskning och diskussion av vetenskapligaartiklar där olika studiedesigner jämförs.

Obligatorisk närvaro vid schemalagda kurs- och examinationsdagar. Frånvaro vid obligatorisktObligatoriska moment : kursmoment kompenseras med skrftliga inlämningsuppgifter.

10 - 15Antal studenter : Företräde ges till dem som är tidigt i sin forskarutbildning och som har ett kliniskt forskningsämne där nyttan avUrval av studenter :

studiedesign är som störst. Registreringsdatum som doktorand används vid urval.Kursen ges generellt på fredag eftermiddagar mellan kl. 14-16.15 på Norra Stationsgatan 67. FöreläsareYtterligare information :

kommer att vara disputerade forskare i professor Jesper Lagergrens forskningsgrupp, övre gastrointestinal forskning. Kursen riktarsig till kliniskt verksamma doktorander med preferens för klinisk epidemiologisk forskning. Vi inriktar oss på registerbaseradforskning och kliniska prövningar. Artiklar kommer att väljas med tonvikt på gastroenterologisk och kirurgisk forskning men fokusligger på för - och nackdelar i studiedesign. Stor vikt läggs vid tillämpning av kunskapen inriktad mot det egna ämnet och egnaplanerade forskningsstudier.

Kursansvarig : Tomas BexeliusInstitutionen för molekylär medicin och kirurgi

[email protected]

N Stationsgatan 67

17670Stockholm

Kontaktpersoner : Margrete GellervikInstitutionen för molekylär medicin och kirurgi

[email protected]

Title : Datainsamling- och dataanalys I: Introduktion till kvalitativa metoder




Särskild behörighet : Efter kursens slut ska studenten kunna att *Förstå principerna som ligger till grund för beslut angående valKursens lärandemål :

av metod i kvalitativ datainsamling och dataanalys. *Förstå olika sätt att tillgodose trovärdighet i kvalitativ forskning. *Förstå olikametoder för datainsamling och analys av kvalitativa data och dess användbarhet inom forskning i vårdvetenskap *Applicera en avmetoderna på studentens egen forskning.

Vetenskaplig och filosofisk hemvist för kvalitativ forskning Metoder för datainsamling och -analys som vanligenKursens innehåll : förekommer i kvalitativ vårdvetenskapsforskning Validering av kvalitativ forskning

Kursen kommer att bestå av föreläsningar, handledning och seminarier. Kursen är fördelad på 5 veckor med 5Arbetsformer : kurstillfällen. Den första är en introduktion och de följande tre är föreläsingar med seminarier. Mellan dessa kurstillfällen skastudenterna göra individuella studier med tillgång till elektronisk handledning. Det femte och sista kurstillfället kommer att vara ettkritiskt granskande diskussionsseminarium.

Examinationen består genomgång av forskningslitteratur som ska avrapporteras både skriftligt och diskuteradeExamination : muntligt på seminarier.

Deltagandet i alla seminarier är obligatoriskt. Frånvaro från seminarier måste kompenseras med enObligatoriska moment : skriftlig granskande diskussion på ett tema relaterat till seminarieinnehållet.

10 - 20Antal studenter : Företräde ges till doktorander vid Nationella Forskarskolan i Vårdvetenskap. Urval sker utifrån sökandesUrval av studenter :

motivering till att gå kursen.Datum för kurstillfällen är 21-22 februari, 28-29 feb, 13-14 mars samt avslutar den 17-18 april medYtterligare information :

examinationer. Kursen ges vid Örebro Universitet.

Kursansvarig : Lena KochInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]


Title : Introduktion till test-teori och analys av kliniska test och enkäter




Särskild behörighet : Målet med kursen är att utrusta kursdeltagarna med en djupare förståelse för koncept och principer för attKursens lärandemål :

guida till rätt val av kvantitativ datainsamlingsmetod och analytiska processer inom vårdvetenskaplig forskning. Efter kursen skastudenterna kunna: - Analysera, värdera, och välja passande metod för kvantitativa datainsamlingsprocedurer - Analysera, värdera,och välja passande metod för analys och tolkning av kvantitativa data - Analysera och diskutera kvalitetskriterier för kvantitativforskning inom vårdvetenskap

Kursinnehållet är i första hand baserat på aspekter relaterade till systematiska insamlingsprocesser förKursens innehåll : kvantitativa data. Kursen introducerar: - Mätningsprocessen och de olika aspekter/steg inkluderade i denna process - Moderntestteori och och aktuella definitioner på koncept (validitet, reliabilitet etc) - Olika kvantitativa datainsamlingsmetoder -Tillvägagångssätt for konstruktion, applikation, analys, och värdeing av kliniska tester/enkäter Kursinnehållet är individuellt anpassatför studier av en specifik aspekt i datainsamlingsprocessen (en klinisk test/enkät) som väljs av studenten och som är relaterat tillhans/hennes eget doktorandprojekt. Denna aspekt presenteras av studenten på kursdag 1 och kommer att vägleda den individuellalärandeprocessen under kursen.

Den pedagogiska inramningen på kursen är centrerad kring studentens egna forskningprojekt. Kursens innehållArbetsformer : introduceras genom föreläsningar och kliniska tillämpningar. Studenterna använder sig sedan av de processer/metoder de lärt sig iworkshops och i grupparbeten med handledning. Resultaten presenteras och diskuteras i seminarieform. Slutligen använderstudenten kursinnehållet på en individuellt vald aspekt på kvantitaiva datainsamlingprocesser i hans/hennes egna forskningsprojekt.

Examinationen består av en skriftlig uppgift baserad på en individuellt vald aspekt av kvantitativExamination : datainsamlingsprocess i studentens egna forskningprojekt. Kvaliteten på uppgiften bedöms utifrån lärandemålen i relation tillspecifikt givna kriteria på kursen. Rapporten/uppgiften presenteras även på ett seminarium.

Seminarier är obligatoriska. En student ska kunna kompensera frånvaro med en skriftlig inlämningsuppgift.Obligatoriska moment : 10 - 20Antal studenter :

Förtur ges till doktorander vid Nationella Forskarskolan i vårdvetenskap. Urval sker utifrån sökandesUrval av studenter : motivering till att gå kursen.

Kursdatum: 120305, 120306, (120309), (120312), 120314, 120315, 120322, 120329Ytterligare information :

Kursansvarig : Anders KottorpInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Kontaktpersoner : Anders KottorpInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Lena KochInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Title : Interview techniques in health and care research



ForskarnivåNivå : Department of Clinical NeuroscienceKursansvarig institution :

Särskild behörighet : After the course the student is expected to be able to identify and understand the content of a researchKursens lärandemål :

interview. Demonstrating and mastering necessary interview tools in order to, independently, being able to analyze and adapt thisknowledge and practical skills in order to compose; i.e. to plan, design and to conduct a research interview. Communicating andgiving feedback to other students relating knowledge with practical demonstrations. Furthermore to have gained an increasedunderstanding and a professional attitude of the researcher as an instrument for data collection which can be applied and enhancethe quality of data in future research interviews.

*different perspectives and knowledge for conducting interviews the role of empathy in communication theKursens innehåll : researcher´s role as an instrument in data collection *intersubjectivity, biases and ethical considerations of interviewing *how to planan interview guide *how to formulate questions *how to conduct an interview with respect for culture and vulnerable groups

The course will be offered part-time, either mornings (9-12 a.m.) or afternoons (1-4 p.m.), on average 8 hours perArbetsformer : week including; lectures, video demonstrations covering various interviews and interview techniques, interview technique trainingseminars in small groups, supervision seminars (interview guide), literature seminars and self-monitored studies and practise. Sinceinterview training is a process which requires testing ¿in vivo¿, improvements, reflection between training, the course covers a5-week period.

Examination will consist of an interview guide and of an individually taped documentation of an interview with aExamination : research subject in the own research field presented in the course group. The presentation will furthermore be within a theoreticalframe of reference including the course literature, discussing interviews, interview techniques, potential biases challenging thequality of the interview responses. The reason behind choosing this kind of examination is that it has been proven to give earlierinterview student-groups valuable learning experiences which immediately can be applied in their research area.

The education will be compulsory scheduled all through the course. If the student is unable to be presentObligatoriska moment : he/she has to consult the course leader/examinator for adequate opportunities to recover missed hours (usually in the form of writtenassignments, besides the video-taped interview).

8 - 12Antal studenter : Förtur ges till doktorander i Nationella Forskarskolan för Vårdvetenskap. Urval sker utifrån sökandesUrval av studenter :

motivering till att gå kursen.Tis 17/1 13-16, Ons 18/1 8-11, Tis 24/1 13-16, Ons 25/1 8-11, Tis 31/1 13-16, Ons 1/2 8-11, Tis 7/2Ytterligare information :

13-16, Ons 8/2 8-11, Tis 14/2 9-16 (obs! Heldag; Examination), Ons 15/2 9-16 (obs! Heldag; Examin.)

Kursansvarig : Gunnel BackenrothInstitutionen för klinisk [email protected]


Title : Introduction to multivariate data analysis




Särskild behörighet : After the course the participants should be able to apply the methods of linear and logistic regression toKursens lärandemål :

analyse data and to know which assumptions these methods rely on.The course will focus on regression analysis, multiple linear regression, logistic regression and regressionKursens innehåll :

methods for ordinal data. Apart from this core a simple nonparametric regression will be introduced as an exploratory method.Methods for the analysis of longitudinal data will be discussed. Other multivariate methods including factor analysis and structuralequation modelling will also be discussed.

The course will consist of lectures, seminars and computer exercises. The lectures will cover the theoretical materialArbetsformer : illustrated with relevant examples. Some material will be presented in seminar form typically discussing an article that theparticipants have read. In the computer exercises the participants will apply their knowledge practically. This work will be handed inand be part of the examination.

The course examination will consist of written work from the computer exercises where results will be presentet andExamination : discussed.

Preparation for and active participation in the seminars. If absent from a seminar the participant will haveObligatoriska moment : to hand in a written assessment.

10 - 20Antal studenter : Urval sker efter motivering att gå kursen.Urval av studenter :

Kursdatum är: 23, 26, 30 april, 3, 7 samt 9 maj. Ytterligare information :

Kursansvarig : Kimmo SorjonenInstitutionen för klinisk neurovetenskap

[email protected]


Title : Global Malaria Eradication



ForskarnivåNivå : Department of Microbiology, Tumor and Cell BiologiKursansvarig institution :

Särskild behörighet : After the course the students will have knowledge about (1) the past and present efforts of human beings toKursens lärandemål :

eliminate malaria (2) how currently observed genetic properties of parasite, mosquito and human have been diverse in variousenvironments and how they are affecting malaria transmission, infection and disease, (3) skills to analyze their associations, and (4)altitude to think about in their research subjects what is a better elimination strategy in this area-specific context ,

Aims The UN Millennium Goals have adopted malaria as a top priority. A major problem is howeverKursens innehåll : area-specific diversity, which affects disease and intervention. The completion of the genome sequences of Homo sapiens,Plasmodium falciparum, and Anopheles gambiae heralds a new era. We apply the new insights to the on-going research in isolatedareas. Islands provide natural experiments. The expansion of parasites is coinciding with humans. Tracing the routes from mainlandAfrica to islands, we aim at a better understanding of how humans, parasites and mosquitoes have co-evolved over time andresulted in the diversity. Our ultimate goal is to develop a novel area-specific strategy in the malaria eradication challenge of the 21stcentury. Contents The course consists of the following topics: 1. Historical thoughts about the efforts of human beings to eliminatemalaria 2. Area-specific diversities of the biological agents in malaria transmission: a) human (immunity/ drug metabolism), b)parasite (antigenicity/ drug resistance) & c) vector (refractoriness/ insecticide resistance) with neutral markers, 3. Evolutionary andecological processes to promote diversities: a) historical human settlement patterns, b) natural environments; climate, island size,fauna and flora, c) socio-cultural environments; inter- and intra-island human movements, language, and community, and d)modernization and development; agriculture, local health system, malaria chemotherapy, use of bed nets, and poverty. e)co-evolutionary processes of biological agents through extension of transmission dynamics & population genetics; 4. Implications ofbiodiversities on immunities and interventions against malaria infection and disease, toward improved malaria elimination strategiesin relation to local characteristics.

Lectures, seminars and small group works.Arbetsformer : Students are asked to write a short essay on a subject selected from the topics in the course. It is to be reviewed byExamination :

a peer student. Assessment will be based on both the original essay and the review report.Obligatoriska moment :

10 - 25Antal studenter : By interviewUrval av studenter :

Professor Noboru Minakawa, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan NoboruYtterligare information : is one the most active entomologist working on the malaria research in Tropical Africa.

Kursansvarig : Akira KanekoInstitutionen för mikrobiologi, tumör- och [email protected]

Nobelsv 16MTC17177Stockholm

Kontaktpersoner : Akira KanekoInstitutionen för mikrobiologi, tumör- och [email protected]

Nobelsv 16MTC17177Stockholm

Title : Clinical Immunology in Infectious Diseases



ForskarnivåNivå : Department of Medicine, HuddingeKursansvarig institution :

Särskild behörighet : By completing this course the students will be able to account for different immunological processes in theKursens lärandemål :

host defence against pathogens. In particular, the students will be able to explain the concepts of innate and adaptive immunity andtheir important roles at different stages in the host defence against pathogens. Student will also be able to describe differences inacute and chronic infections with respect to immunological processes. In addition, the students will be able to give details aboutdifferent pathogens and explanations for their different strategies of immune deviation. Finally, this course will increase thestudents-- skills to communicate research projects.

This course is mainly made up of lectures and seminars. Review articles related to the lectures distributedKursens innehåll : during the course. In addition, some parts of the course involve team-work. The following will be covered during the course:Immunological processes important in the host defense against pathogens; Innate and adaptive immunity; Strategies used bypathogens to subvert the host immune system to avoid eradication; Acute and Chronic infections; Emerging infections; Infectionsand the link to autoimmune disease; Pathogens that will be covered are bacteria, viruses, parasites and fungi; The latest therapiesused in the clinics to fight infections. The course also involves site visits to the Infectious disease clinic and the intensive care unit.As exam, the students will have both a written and oral assignment. This includes writing a brief research proposal within the field ofinfection and immunity as well as presenting the proposed research for the course participants.

Lectures, team-work and project assignment (written and oral), peer-and self assesement and oral presentations.Arbetsformer : Project assignment (written and oral presentation)Examination :

Lectures, project work (written assignment) and the day of examination (oral exam), is compulsory.Obligatoriska moment : Compensation for absence from oral presentation may be possible after discussion with the course organisers. Possible actions mayinclude an oral examen at a separate occasion with the course organizers.

15 - 20Antal studenter : Priority will be given to students on basis of their motivation and topic of their PhD thesis project, and secondlyUrval av studenter :

depending on length since registration.The course will be held at Karolinska University Hospital in Huddinge.Ytterligare information :

Kursansvarig : Linda JohanssonInstitutionen för medicin, Huddinge

[email protected]

Kontaktpersoner : Anna SörensenInstitutionen för mikrobiologi, tumör- och cellbiologi

[email protected]

Title : Pathogen-Host Interactions Research Seminar Series




Särskild behörighet : By completing this course the students are expected to have improved their knowledge of the mechanismsKursens lärandemål :

regulating host-microbe interactions, and they should be more aware of the frontline research activities of the scientific community inthe field. More specifically, they will be able to compare and differentiate the different processes and the different molecular playersthat are involved in the interactions between the host and the various microbial agents such as viruses, bacteria, parasites etc. Sincethe course is organized to encourage analytical and critical thinking, they should also be able to evaluate the relevance of the topicsdiscussed for their future research activities and PhD studies. Finally, this course will increase the students' skills to communicatescience.

This course is made up of fifteen lectures/seminars held by invited speakers from Karolinska Institutet and otherKursens innehåll : institutions in Sweden, who are experts on topics related to host pathogen interactions and infection biology. In addition, 2-3international keynote speakers will be invited. The speakers will be asked to organize their talks to give a comprehensivepedagogical review of the area as well as a description of their own research work. Review articles related to the lectures aredistributed during the course. By discussing selected examples of host/microbe interactions during the lectures, the course willparticularly focus on the routes and mechanisms of infection, the susceptibility and the response of the host to such infections, andthe molecular and physiological events leading to the clearance of microbes or a diseased state. Innate and adaptive immunity,inflammation, and the biology of membranes and receptors will thus also represent main topics for the discussions, which will beheld to meet the students¿ main scientific interests. As examination, the students prepare and present a for the course participants.

Seminars, teamwork and project assignment (oral), peer-and self-assessment and oral presentations. Each seminarArbetsformer : will be followed by a scientific discussion led by the course organizers, where the students are expected to actively interact with theinvited speaker. They are therefore required to prepare before hand by reading literature pertinent to the talk, which will be providedby organizers upon speakers¿ suggestion.

For the final examination, the students will be divided into groups and assigned a scientific subject related to aExamination : specific area of host-microbe interactions. Full credit (3 credits) will be given to the students following an exam that will take the formof an oral presentation, based on the implementation of provided literature with the concepts and ideas discussed during the courseon the specific subject. The students will be required to peer-review other groups¿ work by asking them questions and filling in aquestionnaire at the end of the exam. The overall assessment of the students will thus be based on their presentation, theparticipation to the discussion, and the questionnaire.

Keynote lectures (held by leading experts from abroad) are compulsory. Students who cannot attendObligatoriska moment : seminars will be required to write a half page summary of the seminar material for each of the seminars they did not attend. Groupassignment and the day of examination (oral exam) are also compulsory. Compensation for absence from oral presentation may bepossible after discussion with the course organizers. Possible actions may include an oral exam at a separate occasion with thecourse organizers.

10 - 25Antal studenter : Priority will be given to students on basis of their motivation (topic of phD project) and secondly depending onUrval av studenter :

length since registration.Seminars will be held weekly on Wednesdays at 1pm (MTC, Room A302, Nobels väg 16, Solna). ThereYtterligare information :

will be no seminars on April 4 and 11, the weeks before and after Easter. An exam will be held during the last week of the course(May 16). This is in the form of an oral presentation of specific subjects based on the implementation of provided literature wihconcepts and ideas discussed during the course. 2-3 keynote speakers will be invited to give seminars. Attendance at keynotelectures is compulsory. If a student is unable to attend a seminar they will be required to write a half page summary of the courseliterature for that seminar.

Kursansvarig : Anna SörensenInstitutionen för mikrobiologi, tumör- och cellbiologi

[email protected]

Kontaktpersoner : Antonio RothfuchsInstitutionen för mikrobiologi, tumör- och cellbiologi

[email protected]

Nobels väg 16

171 77Stockholm

Susanne NylenInstitutionen för mikrobiologi, tumör- och [email protected]

Nobelsväg 16

171 77Solna

Title : Biostatistics IV: Applied Longitudinal Data Analysis




Knowledge in epidemiology and biostatistics equivalent to "Epidemiology I: Introduction to epidemiology",Särskild behörighet : "Biostatistics I: Introduction for epidemiologists" and "Biostatistics II: Logistic regression for epidemiologists" or correspondingcourses.

After successfully completing this course you as a student are expected to be able to: 1) Describe theKursens lärandemål : statistical methods utilized to analyze longitudinal data in a variety of settings and with a variety of types of outcome variables. 2)Analyze a scientific problem that requires repeated measurements, identify an appropriate design, and identify the statisticalmethods required to analyze the data. 3) Utilize statistical software (e.g., Stata) to perform longitudinal analyses of data generatedfrom randomized and observational studies with repeated measures designs. 4) Apply modern methods for the analysis oflongitudinal data to a range of settings encoutered in biomedical and public health research. 5) Interpret and communicate theclinical/scientific meaning of the results of a longitudinal analysis. Learning outcomes are classified according to Bloom's taxonomy:knowledge, comprehension, application, analysis, synthesis, and evaluation.

The course gives an introduction to modern methods for the analysis of longitudinal and repeated measuresKursens innehåll : studies which are commonly used in epidemiological studies and in clinical trials. The defining feature of a longitudinal study is thatmeasurements of the response are taken repeatedly through time. The primary goal of a longitudinal study is to characterize changein the response over time and the factors that influence change. A feature of longitudinal data that complicates their analysis is thepositive correlation (i.e., lack of independence) among repeated observations and possible heterogeneity of variability acrossmeasurement occasions. The first part of the course covers general linear regression models for longitudinal data when theresponse variable is continuous. The course covers the following topics: Introduction to longitudinal data, notation for correlateddata, modeling the mean response (analysis of response profiles, parametric and semi-parametric trends), modeling the covariance,growth curves, linear mixed effects models. The second part of course presents an overview of methods for analyzing andinterpreting the results of longitudinal studies when the outcome variable is discrete. This course covers general regression modelsfor longitudinal data when the response variable is discrete (e.g., binary or count data). Topics covered in the course will include:introduction to generalized linear models (e.g., linear, logistic, and Poisson regression), extensions of generalized linear models tolongitudinal data, marginal models and GEE, random effects models for categorical data (generalized linear mixed models),contrasting marginal and mixed effects models. The course is intended for all students interested in epidemiology, biostatistics andpublic health.

Lectures, computer lab with exercises focusing on analysis of real data sets using statistical software (Stata), groupArbetsformer : discussions, literature review.

To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methodsExamination : used are group assignments and an individual written examination. The focus will be on understanding concepts and theirapplication to analysis of epidemiological studies, rather than mathematical detail. The examination is viewed as a contributing to thedevelopment of knowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examinationwill be offered a second examination within two months of the final day of the course. Students who do not obtain a passing grade atthe first two examinations will be given top priority for admission the next time the course is offered. If the course is not offeredduring the following two academic terms then a third examination will be scheduled within 12 months of the final day of the course.

Only the examination is compulsory.Obligatoriska moment : 12 - 25Antal studenter :

Prior knowledge equivalent to "Epidemiology I", "Biostatistics I" and "Biostatistics II" or corresponding courses.Urval av studenter : Eligible doctoral students will be prioritized according to 1) the relevance of the course for their research, and 2) the statedmotivation for attending the course. To be considered, submit a completed application form and give all information requestedincluding a short description of current research and motivation for attending, as well as an account of previous courses taken.

Garrett Fitzmaurice, Associate Professor at the Department of Biostatistics, Harvard School of PublicYtterligare information : Health. He is also an adjunct faculty at the Department of Medical Epidemiology and Biostatistics. Dr. Fitzmaurice works withlongitudinal models and missing data problems and he is the first author (together with Professors Laird and Ware) of AppliedLongitudinal Analysis. Dr. Fitzmaurice is known worldwide to find the right balance between methodology and practical dataanalysis. For more information about the course, please see link:http://ki.se/ki/jsp/polopoly.jsp?d=32260&a=107895&cid=32262&l=en

Kursansvarig : Rino BelloccoInstitutionen för medicinsk epidemiologi och [email protected]

Brännkyrkagatan 45

11822Stockholm

Title : Surgical techniques in rat and mouse



ForskarnivåNivå : Department for Clinical Science, Intervention and TechnologyKursansvarig institution :

The student in the course should have passed the Karolinska Institute´s Lab Animal Science Course orSärskild behörighet : eqvivalent at another university.

After the course the participants are expected to 1.Be able to perform jugular vein cannulation 2.Be able toKursens lärandemål : identify and give examples of important surgical and ethical aspects on study design and methodology in research projects involvinganimals and to communicate this knowledge to peers.

Anaesthesia, analgesia and perioperative care, aseptic surgical techniques, basic surgical techniques includingKursens innehåll : instrumentation, suturing and tissue handling, vein and artery cannulation, explorative laparotomy and blood sampling techniques.Rat will be our main model during the course (as techniques is easier to learn in a larger model), but mouse will also be available.

A minor part of the learning activities are lectures (15%). The remaining part of learning activities are laboratoryArbetsformer : work with practical instructions and learning in groups (tutoring available).

Assessment of learning outcomes To satisfactorily complete the course the student must 1.Be able to performExamination : jugular vein cannulation 2.In a oral presentation and a written report of a provided fictive research projects demonstrate that youhave reached the learning outcome (no 2 above).

The learning in groups are compulsory. Absence can be compensated by a written report.Obligatoriska moment : 8 - 16Antal studenter :

Since the number of students is so limited the selection process will be based on: 1. the student has to haveUrval av studenter : very good practical experience with rats or mice 2. the student has to send in a strong motivation letter. Explain which technical skillsyou already have today when working with rats or mice 3. the student when selected has to hand in a summary of their researchproject and a list of publications 4. the doctoral students have to be already registered at KI

Aim of the course: To provide doctoral students, post docs and assistant professors knowledge aboutYtterligare information : surgical techniques in the rat and mouse. Intended learning outcome: After the course the participants are expected to: 1) haveknowledge to perform pre, peri and post-operative care of animals, including asepsis, anaesthesia and analgesia 2)be able toperform jugular vein cannulation and to collect blood Themes of the course are: Aseptic surgical techniques, analgesia andperi-operative care, basic surgical techniques including instrumentation, suturing and tissue handling, vein and artery cannulation,explorative laparotomy and blood sampling techniques. Rat will be our main model during the course, but mouse will also beavailable. The course is based on learning by practicing and in group projects. Therefore, the presence of participants is requiredduring all scheduled sessions. The language of the course is English. The course will be given at Karolinska Institutet, CampusSolna. The course is given in cooperation with Department of Physiology and Pharmacology and the Department of Zoophysiologyat the University of Gothenburg.

Kursansvarig : Solveig TjäderKomparativ medicin

[email protected]


Berzelius väg 13

171 77STOCKHOLM

Title : How to write a scientific paper - and get published




Särskild behörighet : The aim is that participants achieve a solid understanding of scientific written communication and raise theirKursens lärandemål :

competence in writing articles, and in handling the process of getting articles published. The students should have started theprocess of writing scientific articles already before the course. After the course the participants should know how to write articlesreporting both quantitative and qualitative data, how to avoid the most common mistakes, how to select an appropriate journal, howto respond to reviewers' comments and how to communicate with editors. The course is most useful for students in the researchfields of public health, caring sciences, clinical practice, epidemiology and applied medicine.

Science as communication The writing process: structure, language, style, the elements of a scientific article Kursens innehåll : Writing an article with quantitative data Writing an article with qualitative material Assignments to write parts of an article with ownmaterial Feedback on written assignments for group discussions and reflections Reviewing assignments by other students Casework on the review process Publishing articles from the Editor's point of view

Interactive plenary sessions are combined with group work with or without teachers. Group work includes focusedArbetsformer : exercises and case discussions. The course is based on participants' written assignments with material from their own research.These assignments are assessed by teachers and feedback regarding style and content is given during the course, both on anindividual and on a group level. The students are also assigned to comment on other students' exercises. Time is allocated forindividual work on assignments and for reading the course literature. One assignment should be delivered before the start of thecourse.

The examination takes the form of assessment of the students' competence to respond to feedback and improveExamination : their skills in scientific writing during the course. The level of performance regarding the final assignments are the basis for thisevaluation.

The plenary sessions and the group work are compulsory as well as the written assignments. AbsenceObligatoriska moment : has to be compensated at an individual level. A compulsory assignment has to be completed and sent to the course organisersabout two weeks before the course start.

28 - 35Antal studenter : 1. PhD students registered at KI who have at least started writing one article and who are doing their researchUrval av studenter :

within the research fields of public health, caring sciences, clinical practice, epidemiology and applied medicine. 2. Date ofregistration. Ytterligare information :

Kursansvarig : Rolf WahlstromInstitutionen för folkhä[email protected]

Kontaktpersoner : Kersti RadmarkInstitutionen för folkhälsovetenskap

[email protected]

Title : How to write a scientific paper - and get published




Särskild behörighet : The aim is that participants achieve a solid understanding of scientific written communication and raise theirKursens lärandemål :

competence in writing articles, and in handling the process of getting articles published. The students should have started theprocess of writing scientific articles already before the course. After the course the participants should know how to write articlesreporting both quantitative and qualitative data, how to avoid the most common mistakes, how to select an appropriate journal, howto respond to reviewers' comments and how to communicate with editors. The course is most useful for students in the researchfields of public health, caring sciences, clinical practice, epidemiology and applied medicine.

Science as communication The writing process: structure, language, style, the elements of a scientific article Kursens innehåll : Writing an article with quantitative data Writing an article with qualitative material Assignments to write parts of an article with ownmaterial Feedback on written assignments for group discussions and reflections Reviewing assignments by other students Casework on the review process Publishing articles from the Editor's point of view

Interactive plenary sessions are combined with group work with or without teachers. Group work includes focusedArbetsformer : exercises and case discussions. The course is based on participants' written assignments with material from their own research.These assignments are assessed by teachers and feedback regarding style and content is given during the course, both on anindividual and on a group level. The students are also assigned to comment on other students' exercises. Time is allocated forindividual work on assignments and for reading the course literature. One assignment should be delivered before the start of thecourse.

The examination takes the form of assessment of the students' competence to respond to feedback and improveExamination : their skills in scientific writing during the course. The level of performance regarding the final assignments are the basis for thisevaluation.

The plenary sessions and the group work are compulsory as well as the written assignments. AbsenceObligatoriska moment : has to be compensated at an individual level. A compulsory assignment has to be completed and sent to the course organisersabout two weeks before the course start.

28 - 35Antal studenter : 1. PhD students registered at KI who have at least started writing one article and who are doing their researchUrval av studenter :

within the research fields of public health, caring sciences, clinical practice, epidemiology and applied medicine. 2. Date ofregistration. Ytterligare information :

Kursansvarig : Rolf WahlstromInstitutionen för folkhä[email protected]


[email protected]

Title : Advanced seminars in Tumor Biology




Särskild behörighet : Efter kursen skall doktoranden kunna diskutera och förstå avancerade cell- och tumörbiologiskaKursens lärandemål :

frågeställningar som vanligen inte står att finna i läroböcker. De skall också kunna värdera och diskutera hur man löser problem,metodologiska tillvägagångssätt i forskningsfronten, även utanför sitt eget specifika kompetensområd. De skall framförallt kunnadiskutera och värdera nya data inom dessa områden, men också få en up-to-date översikt över ämnet som ingen lärobok kan ge,pga ämnets snabba progress. Detta sker i seminarieform som leds av en nationell eller internationell forskare, samt en av lärarna urkursledningen. Frågor och diskussion efter presentation av seminariehållaren.

Kursen kommer att belysa och diskutera forskningsfronten inom stora delar av ämnet tumörbiologi ochKursens innehåll : experimentell onkologi. Ämnen som berörs är cellcykel, apoptosis, signaltransduktion, cancergenetik, epigenetik inklhistonreglering, cancerstamceller, proteomik inkl ubiquitin reglering, tumörimmunologi, infektioner och cancer, matematiskmodellering, angiogenes, cell-cell communication, tumörers heterogenitet, vävnadsbiologi med anknytning till cancer, nyabehandlingskoncept, samt problem inom klinisk cancerforskning.

Föresläsningar och/eller seminarier i grupp med diskussion en gång/vecka. Föreläsningarna följs av diskussion medArbetsformer : studenterna. Komplettering med litteraturstudier av forskningsartiklar. Omfattningen är ca 18 veckor med sammanlagt ca 20seminarietillfällen, samt två-tre tillfällen i mindre grupp.

Skriftlig examination i slutet av kursen i form av hemtentamen. Essayfrågor för att visa förståelse och mognadsgrad,Examination : samt enstaka kunskapsfrågor.

Seminarierna är obligatoriska. Enstaka missade seminareitillfällen kan kompenseras på annat sätt efterObligatoriska moment : diskussion med kursledaren. Intagning sker efter diskussion med kursledaren.

8 - 20Antal studenter : Based on research area, motivation and need to take the course, and if equal level, on progress of studiesUrval av studenter :

measured by publications and time since registration.Lectures and seminars with discussions once a week. Litterature studies (research articles) on someYtterligare information :

subjects connected to the seminars. Leading scientists at KI and some top-scientits outside KI are invited as speakers. Appr 20seminars, incl 2 occassions in smaller groups. Most of the seminars are held on Tuesdays at 13.00 at MTC, KICampus. Writtenhome exam with essay questions at the end of the course. Subjects include cell cycle, apoptosis, signal transduction, cancergenetics, epigenetics, cancer stem cells, proteomics incl the ubiquitin-proteasome system, cell-cell communication, tumorheterogeneity, infections & cancer, tumor immunology, angiogenesis, mathematical modelling, new treatment concepts andproblems in clinical cancer research.

Kursansvarig : Ingemar ErnbergInstitutionen för mikrobiologi, tumör- och [email protected]

Box 280, Karolinska Institutet

17177Stockholm

Kontaktpersoner : Teresa FrisanInstitutionen för cell- och molekylä[email protected]

Berzelius väg 35

S-17177Stockholm

Title : What is life? The future of biology.




Särskild behörighet : After the course students shall be able to discuss: 1. Theories about complexity of biological systems 2. HowKursens lärandemål :

biocomplexity can be studied. 3. What is the place of computational simulations in modern biology? How simulations can be done?What the predictive power is. How mathematics can be used in simulating biological phernomena. 4. How one understands theorganizational principles of biological systems. If self-organization is a field for study or just a trivial phenomenon. 5. Howevolotionary theory can be formalized into mathematical models. 6. If quantum mechanical theory can have a role in molecularbiology. 7. How genetic information can be converted to mechanical or electrical force in biological system. The students will alsoaquire an understanding of the conceptual and technical challenges in future biomedicine and advance your ability to ask scientificquestions and identify significant - and possible - areas for problem solving.

Inspired by the seminal book by Erwin Schrödinger What is life? published 60 years ago we will adress thisKursens innehåll : question again, in view of the impressive development since then. There are many new concepts to consider in the future of biology,such as the consequencies of the -omics era, complexity, computation and simulation, as well as the role of mathematicss andphysics in biological theory. The course will cover areas such as biocomplexity, quantum mechanical theory in biology, computationand simulation (in silico biology), organization of biological systems, causality in biology, how does chemistry become electric andmagnetic forces and evolutionary theory in the light of molecular biology. Leading scientists with an overview perspective will beinvited to discuss in the seminar form the challenges that meet us today in biology, as a result of the --omics era, the availability oflarge amounts of data as a result of high through-put techniques, and the possibilities provided by mathematics, simulation theoryand computational biology. Young scientists in this areas are also invited to lecture from their perspective. Invited experts will reviewthese areas in lectures. They will also meet the students for an additional two hours in a workshop discussion of basic concepts.

Two seminars+worskhop every month for five months, 2,5-3 hrs on each occassion. Every occasion consists of aArbetsformer : appr 1-2 hour seminar/lecture with the invited expert followed by a two hour open discussion, i.e 3-4 hours on each occassion. Foreach seminar the students will usually be given at least one article on the topic to read. Active participation in discussions in groupswith invited speaker of high international standards is a key element. You also receive DVD-recordings of all lectures for further selfstudies at home.

Continuous by workshop discussions. Written home-exam (essay). Examination : The seminars are compulsory. Absence can be compensated for after discussion with the course leader.Obligatoriska moment :

8 - 20Antal studenter : Based on motivation and need to take the course, on area of research, and if equal level on progress ofUrval av studenter :

studies as measured by publications and time since registrationTwo teaching occassions/month, 15.00 - 18.00 including discussions with the students. The lectures andYtterligare information :

discussions are held at KI campus: lectures in one of the larger leture halls like Nobel Forum (Wallenberg lecture hall) and followingdiscussions in seminar room A 302, MTC, Nobels vög 16, KICampus. Comfirmed speakers are Howard Gardner, USA, Rob Riemen(NEXUS, Netherlands), Mark Ptashne, New York and bishop Antje Jacklén, Lund. So far not confirmed Freeman Dyson and RichardDawkins.



17177Stockholm

Kontaktpersoner : Yvonne StrandbergInstitutionen för mikrobiologi, tumör- och cellbiologi

[email protected]

Title : Pathology




The level of the course is adjusted for students with a background in natural science but is open for all PhDSärskild behörighet : students.

After the course the student has knowledge of basic pathological events and can analyse the connection ofKursens lärandemål : these events to the development of disease.

The course is divided into two parts. The first part illustrates cell injury, adaptation and inflammation.Kursens innehåll : Mechanisms of oxidative stress, cellular defence and ageing will be discussed as well as new methods in cellular and molecularpathology. During the second part of the course will focus on tumor development and malignancy. We will discuss how basicpathological responses to inflammation or injury might be the first steps on a multi-step path to malignancy.

This is a full time course with lectures, seminars, demonstrations and microscopy exercises.Arbetsformer : Presentation (individually) and discussion of group projects concerning different pathological events.Examination :

All demonstrations/microscopy/group work are compulsory. Absence must be compensated with a writtenObligatoriska moment : report.

20 - 30Antal studenter : Registration date as a doctoral student.Urval av studenter :

Place: Division of Pathology, Forskningsgatan, F58, Karolinska University Hospital HuddingeYtterligare information :

Kursansvarig : Barbro Ek-RylanderInstitutionen för [email protected]

Kontaktpersoner : Arja KramsuInstitutionen för laboratoriemedicin

[email protected]

Barbro Ek-RylanderInstitutionen för [email protected]

Title : GRUNDLÄGGANDE BIOSTATISTIK OCH EPIDEMIOLOGI




Särskild behörighet : Kursens epidemiologiska huvudsyfte är att studenten skall kunna förstå vissa grundläggandeKursens lärandemål :

epidemiologiska begrepp, som t ex confounding, effect modification och bias. Detta innebär att kursdeltagaren efter slutförande avkursen skall kunna kritiskt granska och diskutera vetenskapliga artiklar inom ämnet. Det biostatistiska huvudmålet är attkursdeltagaren skall lära sig att självständigt använda grundläggande statistiska metoder och kunna tillämpa dem på problem inomdet medicinska området. Studenten skall efter slutförande av kursen kunna beräkna enkla statistiska mått (medelvärde, median,standardavvikelse, etc), skapa diagram (histogram, lådagram, stapeldiagram, cirkeldiagram, etc), utföra parametriska och icke -parametriska tvågruppsanalyser (t-test, Chi2 test, Wilcoxon test, etc), samt utföra styrke - och stickprovsberäkningar. Dessutomkommer kursdeltagarna att få en introduktion till mer avancerade statistiska metoder i form av en kort översikt av linjär regressionoch variansanalys. Efter slutförande av kursen förväntas kursdeltagaren, att med hjälp av kursmaterialet, kunna avgöra vilken/vilkaanalysmetoder som är lämpliga att använda i det egna forskningsprojektet, samt att kunna utföra statistiska analyser med hjälp avprogramvaran STATA 10. Kursdeltagaren skall även kunna avgöra när mer avancerade statistiska metoder behöver användas ochom ett samarbete med en statistiker i så fall behöver inledas. Kursen är även tänkt att kunna ge tillräcklig baskunskap för meravancerade kurser inom epidemiologi och biostatistik.

Introduktion till epidemiologi och biostatistik. Deskriptiv statistik Hypotesprövning (parametriska metoder) Kursens innehåll : Hypotesprövning (Icke - parametriska metoder) Konfidens intervall, styrkeberäkningar, och stickprovsstorleksberäkningar Introduktion till regressionsanalys och variansanalys En kort introduktion till epidemiologiska begrepp

Föreläsningar med genomgång av teoretiska definitioner och statistiska antaganden, samt med tillämpandeArbetsformer : exempel från det medicinska och epidemilogiska området på förmiddagar. Sammanfattning av föreläsningar och praktiska övningar(under handledning) med STATA 10.0 på eftermiddagar. Deltagaren behöver inte ha förkunskaper i programmet STATA, vi delar utalla nödvändiga instruktioner i from av ett kurskompendium, samt har en grundläggande genomgång av programmet. Vid varjeövningsfråga anges vilket STATA kommando som kan användas. Granskning och diskussion av vetenskapliga artiklar iseminarieform och som hemuppgift.

Examination: Kursavsnitten examineras genom individuella datorlaborationer och skriftliga svar på teoretiska frågorExamination : som lämnas in varje dag. Skriftlig uppgift vid händelse av frånvaro på obligatoriska moment, inom 3 veckor efter att kursen avslutats.

Krav: Obligatorisk närvaro vid alla föreläsningar på förmiddagar och introduktion till datorlaborationer påObligatoriska moment : eftermiddagar. Frånvaro kompenseras genom extra. inlämningsuppgift avseende den del av kursen som frånvaron gäller.

12 - 15Antal studenter : Sökande prioriteras utifrån motivering och relevans för forskarplanen. Förkunskaper i programvara STATAUrval av studenter :

eller SAS, SPSS, STATISTICA är önskvärt.Plats: Institutionen för Neurobiologi, Vårdvetenskap och Samhälle (NVS)/Centrum för Allmänmedicin,Ytterligare information :

Alfred Nobels allé 12, Huddinge. Kriterier för att bedöma deltagarnas prestationer inför examination: Kursdeltagarna bedömsindividuellt. Studenterna tillåts att samarbeta under datorlaborationer men på examinationsmoment skall det tydligt framgå att varjeindivid har uppnått tillräcklig kunskap för att självständigt kunna analysera och tolka liknande problem i sina egna forskningsprojekt. -Underkänd: Ej svar på hela frågan, felaktigt svar, osammanhängande resonemang, irrelevanta faktorer som visar på bristandeförståelse. - Godkänd: Korrekt och relevant svar, besvarat hela frågan, korrekta och relevanta fakta, utförligt resonemang kringorsak och verkan.

Kursansvarig : Farhad AlinaghizadehInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Alfred Nobels allé 12

141 83Huddinge

Kontaktpersoner : -

Title : Frontiers in leadership research




Särskild behörighet : To provide the students with an opportunity to discover how leadership research is of relevance for theirKursens lärandemål :

research questions and how knowledge from this area can further illuminate their field of research. One purpose is to offer thestudents a broad network of research associates, senior colleagues and teachers with different research perspectives. After thecourse the students should be able to distinguish between leadership research and social sciences in general and betweencontemporary as well as historical paradigms and to apply knowledge from leadership research in their own research. They shouldbe able to identify when leadership issues must be taken into consideration in research on work environment, quality improvement,work health and organisational efficiency and profitability et cetera.

- Introduction; sketching out the field of leadership research, aspects of leadership in research and theory,Kursens innehåll : current issues and debates - History of leadership research - Contemporary leadership theories - Leadership theories applied inpublic organisations and business - Examination and discussion of students´ essays

Lectures, seminars and group work. Own work includes literature studies and essay writing. Participants who areArbetsformer : interested in distance learning (video conferencing) are welcome to discuss with the contact persons how and if this could bearranged.

The course will be examined in the form of a written term paper in which the students relate the course literature toExamination : their own research. This paper will also be presented and discussed in connection to the termination of the course. This type ofexamination is suitable for the aim of the course with individual outcomes dependent on the students-- background and researchperspective.

Active participation in the seminars which are compulsory. Absences from those activities will have to beObligatoriska moment : made up with written examinations.

10 - 20Antal studenter : The students will be selected firstly by motivation and secondly by time from registration as a doctoral student.Urval av studenter :

The course is a cooperation between Karolinska Institutet (Christer Sandahl), Stockholm School ofYtterligare information : Economics (Mats Tyrstrup), The Swedish Defence College (Gerry Larsson), The Swedish School of Sports and Health Sciences(Urban Bergsten), Stockholm University (Marianne Döös and Magnus Sverke) and KTH Royal Institute of Technology (Matti Kaulio).www.salkforum.se Seminars will be given full days at Karolinska Institutet in Solna the following Tuesdays: Feb 14, March 6, March27, April 17 and May 8.

Kursansvarig : Christer SandahlInstitutionen för lärande, informatik, management och [email protected]

Kontaktpersoner : Therese WahlströmInstitutionen för lärande, informatik, management och [email protected]

Title : Qualitative Research Methods




Särskild behörighet : At the end of the course the students should be able to: - understand and explain the theoretical basis for theKursens lärandemål :

main qualitative methods used in public health research - understand and explain the main differences between qualitative andquantitave research - know the main qualitative research methods used in public health research (content analysis, discourseanalysis, grounded theory, narrative analysis), understand the differences between them and know how to choose the method mostadequate for the research question at hand - plan and carry out a qualitative research interview, a focus group discussion and anobservation session, including know how to handle the information gathered and analyse the data - understand the ethical aspectsof qualitative research and how to handle them in a professional way - explain how the validity/quality is assessed in qualitativeresearch - plan and carry out a qualitative study - prepare the outline of an article based on data collected during the course

- Theoreticl basis for qualitative research - The main qualitative research methods in public health research(Kursens innehåll : participant selection, data collection, handling of data, analysis) - Validity/quality assessment of qualitative resarch - Ethics inqualitative resarch - Reading and writing qualitative research

- Lectures - Group work - Practising observations, interviewing and moderating focus group discussions - PractisingArbetsformer : handling of qualitative data by hand and using software - Practising how to analyse qualitative data and writing it up - Seminars todiscuss the experiences from the practical sessions

- an individual written examination to assess aquired knowledge and understanding of qualitative research -Examination : assessment of the practical assignments and how the experiences are presented in the seminars - the drafts for an article based onthe data collected in the practical assignments to assess the understanding of the process and ability to analyse data and condenseinformation

All practical assignments are compulsory and should to be carried out during the course. If a student isObligatoriska moment : absent compensation should be agreed on with the courseleader and if possible finalised during the course period.

17 - 20Antal studenter : If we have more applicants than places in the course, students who are working with data from low-incomeUrval av studenter :

countries will be prioritized.Ytterligare information :

Kursansvarig : Birgitta RubensonInstitutionen för folkhä[email protected]

Kontaktpersoner : courses-ihcar functionEj satt

[email protected]

Asli KulaneInstitutionen för folkhä[email protected]

Title : Forskningsetik




Särskild behörighet : Efter kursen skall doktoranderna ha tillägnat sig en generell kunskap om etik i forskning, samt förmåga attKursens lärandemål :

självständigt kunna reflektera över och kritiskt diskutera etiska problem som omgärdar den egna forskningsuppgiften samt forskningi allmänhet.

En introduktion till etiken i samband med forskning och en orientering om dess tillämpning på problem inom detKursens innehåll : vetenskapliga området. Kursen behandlar bl.a. följande teman: etiska teorier, forskningsetik, forskaretik, innehåll i och värdet avregelverk, forskningsfusk och vetenskaplig oredlighet.

Föreläsningar (ca 6t), gruppövningar, seminarier(ca 8t) och muntlig och skriftlig presentationArbetsformer : Examination består av aktivt deltagande i seminarier, ett kortare skriftligt PM där ett tema inom ramen för kursenExamination :

behandlas. Detta PM presenteras också muntligt för de andra kursdeltagarna. Doktoranden förväntas relatera temat till det egnaavhandlingsarbetet. Godkänd kurs innebär aktivt deltagande i seminarier och godkänd muntlig och skriftlig presentation avexaminationsuppgiften.

Obligatoriskt är att delta vid introduktionstillfället och vid seminarier. Vid frånvaro kan detta kompenserasObligatoriska moment : med utökat PM skrivande och muntlig presentation för kursen eller kursgivare.



Kursen ges en eftermiddag/vecka (tisdag). Det är obligatoriskt att delta vid alla kurstillfällen. Kursen hållsYtterligare information : på Anestesi- och intensivvårdskliniken, Karolinska Universitetssjukhuset, Huddinge.

Kursansvarig : Sigridur KalmanInstitutionen för klinisk vetenskap, intervention och [email protected]

Kontaktpersoner : Monika ArmuandInstitutionen för klinisk vetenskap, intervention och [email protected]

Title : Vetenskapsteori




Särskild behörighet : Efter kursen skall kursdeltagaren ha en bred kunskap i vetenskapsteori samt förmågan att självständigtKursens lärandemål :

reflektera över och kritiskt diskutera vetenskapsteoretiska problem i vetenskapligt arbete, för både den egna forskningsuppgiften ochforskning i allmänhet.

En introduktion till vetenskapsteorin och en förståelse för olika slag av vetenskapligt kunskapssökande. EnKursens innehåll : grundläggande orientering om vetenskapsteoretiska frågor ges. Följande teman behandlas: begreppet kunskap, vetenskap -pseudovetenskap, hypoteser - hypotesprövning, orsaker - förklaringar, vetenskap ¿ värderingar - samhälle.

Föreläsningar (ca 12 t), gruppövningar, seminarier (ca 14 t) och muntlig och skriftlig presentation.Arbetsformer : Examination består av aktivt deltagande i seminarier, i ett skriftligt PM där ett tema inom ramen för kursen fördjupasExamination :

och behandlas mer utförligt, och genom att detta PM presenteras muntligt för de andra kursdeltagarna. Doktoranden förväntasrelatera temat till det egna avhandlingsarbetet, alternativt andra (centrala) forskningsfrågor inom den egna disciplinen.Godkändlitteraturredovisning vid seminarier samt godkänd muntlig och skriftlig presentation av examinationsuppgift krävs för godkänd.

Obligatoriskt är att delta vid introduktionstillfället och vid seminarier. Vid frånvaro kan detta kompenserasObligatoriska moment : med utökad muntlig och skriftlig presentation vid seminarium eller för kursgivaren.



Kursen ges en eftermiddag/vecka (tisdag). Kursen hålls på Anestesi- och intensivvårdskliniken, KarolinskaYtterligare information : Universitetssjukhuset, Huddinge.

Kursansvarig : Sigridur KalmanInstitutionen för klinisk vetenskap, intervention och [email protected]

Kontaktpersoner : Monika ArmuandInstitutionen för klinisk vetenskap, intervention och [email protected]

Title : To communicate science in different contexts




Särskild behörighet : After the course the student is expected to be able to: 1. Orally present own research adapted to differentKursens lärandemål :

target groups. 2. Reflect on presentation skills and ability to adapt to different target groups.During the course each participant will be given the opportunity to develop practical and theoretical knowledgeKursens innehåll :

in: -- Communication, perception and learning -- Presentation techniques -- Rhetoric -- Use of different media (such as Posters,Overhead-projector, PowerPoint, Whiteboard) Each course participant will perform three oral presentations and receive feedback oncontent, presentation skills and adaptation towards target group.

The course design is based on reflective practice and includes self-directed learning, lectures and literature seminarArbetsformer : to process theoretical knowledge, and practical training in presentation skills.

The assessment consists of two different tasks: 1. Reflective statement based in experience, feedback andExamination : research/literature within communication and learning. 1. Oral presentation in a popular scientific context supported by PowerPointor similar. To pass the course the participant needs to show evidence that they reached the learning outcomes by fulfillment of theassessment criteria.

Compulsory sessions are: 1. Oral presentation in a popular science context (video recorded) 2. OralObligatoriska moment : presentation in a scientific context and observe and give feedback to an oral presentation made by a peer. Absence from thecompulsory sessions or assessment seminar can be compensated through supplementary activity.


(2) your registration date as a PhD student at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KI in your personal profile and that you have ranked the courses you have applied for. Please observe:To this course you have to reply by December the 4th 2011 at getting a preliminary acceptance offer.

The course is a two week course which requires time for independent work outside of scheduled classYtterligare information : time. Scheduled class room sessions (full day) are on the following dates: 21-22 February, 6-7 March and 20-21 March. The courseis given in ENGLISH.

Kursansvarig : Samuel EdelbringInstitutionen för lärande, informatik, management och etik

[email protected]

Kontaktpersoner : Ingrid SmedbergInstitutionen för lärande, informatik, management och etik08-524 837 [email protected]

Title : Att kommunicera vetenskap i olika sammanhang




Särskild behörighet : Vid slutet av kursen förväntas studenterna kunna: 1. Muntligt presentera egen forskning anpassad till olikaKursens lärandemål :

målgrupper. 2. Reflektera över färdigheter i presentationsteknik och förmågan att anpassa budskapet till olika målgrupper. Under kursen ges deltagarna möjlighet att utveckla praktiska och teoretiska kunskaper om: -Kommunikation,Kursens innehåll :

perception och lärande -Presentationteknik -Retorik -Användning av hjälpmedel såsom poster, overhead, PowerPoint, whiteboard Varje kursdeltagare genomför tre muntliga presentationer och får återkoppling på innehåll, presentationsteknik och anpassning tillmålgrupp.

Kursdesignen är baserad på reflekterande praktik och inkluderar självstudier, föreläsningar och litteraturseminariumArbetsformer : för att bearbeta det teoretiska innehållet, samt praktiska övningar för att träna färdigheter i presentationsteknik.

Examinationen består av två uppgifter: 1. En skriftlig reflektion baserad på erfarenheter av och återkoppling påExamination : presentation samt forskning/ litteratur inom kommunikation och lärande. 2. Muntlig presentation i ett populärvetenskapligtsammanhang med stöd av PowerPoint eller motsvarande. För att bli godkänd på kursen krävs att deltagaren visar att lärandemålenhar nåtts genom att uppfylla bedömningskriterierna.

Obligatoriska moment är: 1. Muntlig presentation i ett populärvetenskapligt sammanhang (spelas in påObligatoriska moment : video). 2. Genomföra en muntlig presentation i ett vetenskapligt sammanhang samt observera och ge återkoppling på enkurskamrats presentation. Frånvaro från obligatoriska moment eller examinerande moment kan kompenseras medersättningsuppgifter eller motsvarande.



Kursen motsvarar två veckors heltidsstudier och kräver eget arbete utanför schemalagd tid. FöljandeYtterligare information : dagar är schemalagda (heldagar): 17-18 april, 8-9 maj och 22-23 maj. KURSEN HÅLLS PÅ SVENSKA / COURSE IS GIVEN INSWEDISH.

Kursansvarig : Samuel EdelbringInstitutionen för lärande, informatik, management och etik

[email protected]

Kontaktpersoner : Ingrid SmedbergInstitutionen för lärande, informatik, management och etik08-524 837 [email protected]

Title : From Science to Business -- Concepts in Biotechnology




-Särskild behörighet : The learning outcomes for the course can be subdivided into two broad areas; i) Biotech business includingKursens lärandemål :

finance, strategy, law and regulations and ii) Entrepreneurship and innovation. After the course the candidates will be able to:Biotech business -express understanding for the field of biotechnology business -understand and demonstrate knowledge of thedevelopment and management of biotechnology businesses -argue for advantages and disadvantages with public and privatefinancing of early stage companies -communicate basics in strategy and tools for science based companies (business plan,collaboration between large and small companies, corporate intelligence, role of boards, human resource management etc) -demonstrate theoretical knowledge within the overall legal and regulatory framework for science based businesses (EU and UScorporate law, patenting law, regulatory authorities) -integrate knowledge of key skill-sets for early-stage entrepreneurship andhandle complexity within areas such as market and IP analysis, target product profile, business plan and budgeting.Entrepreneurship and innovation -understand and demonstrate how discoveries and inventions are commercialized -analyse, clearlycommunicate and discuss the context of entrepreneurship with both a specialist and non-specialist audience -analyse and clearlycommunicate and discuss the context of entrepreneurship to both a specialist and non-specialist audience -apply theirunderstanding and knowledge of the basics of innovation and entrepreneurship in a broader context and relate to their own field ofstudy -use their new skills and continue to independently learn more about the area of innovation and entrepreneurship -demonstrate understanding in the theory of clusters of innovation -express knowledge for the universities role in the innovationsystem

The knowledge intensive field of biotechnology has apart from being subject to high expectations from aKursens innehåll : macroeconomic perspective also attracted a strong interest from the large pharmaceutical companies and venture capitalists. Thecourse deals with the development and management of biotechnology businesses, with a focus on commercialising discoveries andinventions. The course consists of seminars based on practice and theory of the different stages of business development as well asa group-project presented in writing and orally. In the seminars the candidates meet practitioners and researchers with a Swedishand international background. The practitioners present specific experiences from starting and running knowledge intensive youngbusinesses or from the financial, legal, political or corporate strategy fields. The broad picture is given by researchers in sociology orbusiness administration with an insight in academic discoveries, start-up companies, venture capital, business expansion and sellingof companies. In the group-project and case studies candidates and students from different schools will work together on topic oftheir choice from one of the main areas of the course. The course is divided into four components: 1. innovation & entrepreneurship 2. law and regulations 3. finance 4. strategy

A combination of guest speakers with theoretical and real-life experiences of starting, running and developingArbetsformer : science based companies. Interactive seminars with focus on discussions on the different topics combined with actual use of theprovided knowledge.

Class attendance and participation. Group-thesis, case assignment and oral presentations.Examination : There is compulsory attendance in the seminars, case work and presentations. Failure to attend obligatoryObligatoriska moment :

parts of the course may be compensated for by completion of appropriate assignments, decided on in agreement with the courseleadership and judged on a case-to-case basis.

10 - 20Antal studenter : Students will be selected based on their written motivation.Urval av studenter :

The courses will run on Tuesday and Thursday evenings between 17:00 and 20:00 at KI campus Solna. Ytterligare information :

Kursansvarig : Carl J SundbergInstitutionen för lärande, informatik, management och etik

[email protected]

Kontaktpersoner : Madelen LekInstitutionen för lärande, informatik, management och etik

[email protected]

Title : Genetics of complex diseases



ForskarnivåNivå : Department of Biosciences and NutritionKursansvarig institution :

Särskild behörighet : After the course students should be able to * understand the mechanisms of complex diseases * useKursens lärandemål :

learned approaches for genetic studies to make their own project design * know how to use information from public databases. Course will cover topics such as 1- Beyond Human genome project: next generation sequencing 2- GeneticKursens innehåll :

linkage and association (study design and analysis) 3- Structural variation and copy number analysis 4- DNA methylation 5- Nextgeneration sequencing (study design and data analysis) 6- Bio-technology and database use

Lectures and group work with an assigned projects Arbetsformer : The exam is in a format of oral presentation for corresponding project work.Examination :

Obligatory attendance to all lectures and seminars. A written summary based on missing lecture(s) isObligatoriska moment : needed to compensate absence.

15 - 20Antal studenter : Selection 1) the usefulness of the course for the doctoral student for his/her individual study plan. 2) theUrval av studenter :

motivation given in the application to the course. The course will be held during 2012 April 16-27 at Department of Biosciences and Nutrition, NOVUM, CBTYtterligare information :

seminar room, Elevator E, 6th floor. Specific content: next generation sequencing application and data analysis

Kursansvarig : Hong JiaoInstitutionen för biovetenskaper och näringslä[email protected]

Kontaktpersoner : Monica AhlbergEj satt

[email protected]

Title : Exploring human movement with computerised movement analysissystems




Särskild behörighet : At the end of the course, the students should be able to: * formulate clear research questions in the field ofKursens lärandemål :

movement science and be able to set up adequate experiments for them. * in groups, conduct a scientific experiment in themovement laboratory. * analyse kinematic, kinetic and EMG data. * clearly present the results in oral and written form (includinggraphs). *-- evaluate their results by comparing them with the litterature.

* Working in the lab with computerised movement analysis systems: o Kalibrering, datainsamling och analys oKursens innehåll : Signal processing of movement trajectories from reflecting markers, of Electromyography (EMG) and force plate data. *Biomechanics * Motor control * Muscle physiology * Training in experimental skills * Training in presentation skills

This course has three parts. The first part is a theoretical part, in which the students learn the basics of movementArbetsformer : science by means of lectures, group work litterature studies and individual work (3 days). The second part is laboratory work inwhich the students learn a) the principals of computerised movement analysis systems with calibration, marker placement, EMG,and forceplate measurements; b) learn to formulate a movement scientific research question (PM); and c) learn to accomplish anlaboratory experiment - group work (5 days). The last part is the presentation part, in which the students present their laboratoryresults in both a written rapport and in zig-zaw group seminars (2 days).

The teachers give their judgement on the oral presentations and the written laboratory report. Moreover, student peerExamination : assessment on the oral presentations.

This course has three compulsory parts: 1. Oral presentation of the movement scientific research questionObligatoriska moment : (PM-presentation). 2. Active participation in the laboratory experiment. 3. Active participation in the zig-zaw group seminars. Absence at these compulsory parts, the students have to compensate this with: 1. A written presentation of the movement scientificresearch question (PM). 2. Participate in an other laboratory experiment. 3. A written summary of a number of laboratory reports,including reflecting comments.

6 - 20Antal studenter : Those students that have (the possibility to collect) own data are in priority, because collecting data at our labUrval av studenter :

is very time consuming. Otherwise, those that have reached their half-time seminar are the other group that will be offered a place inthe course in case of lack of places.

We run on the course on thursdays and fridays, 8-9 march, 15-16 march, 22-23 march, 29-30 march withYtterligare information : lots of space for working on your own data. The final seminars will be held during 19 and 20 april.

Kursansvarig : Wim GrootenInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Kontaktpersoner : -

Title : Social kompetens: Presentationsteknik, samarbete och relationsbyggande



ForskarnivåNivå : Department of Women's and children's healthKursansvarig institution :

Inga krav på förkunskaperSärskild behörighet : Efter genomgången kurs ska doktoranden ha: - verktyg för att på ett framgångsrikt sätt presentera sinaKursens lärandemål :

forskningsresultat - förståelse för hur vi påverkar en publik genom exempelvis vårt kroppsspråk - lärt sig ta till vara på sina styrkorsom talare - kunskap om hur man disponerar och strukturerar ett budskap respektive en presentation - en djupare förståelse för demekanismer som främjar respektive bryter ner samarbetet mellan individer eller inom en grupp - förståelse för varför samarbete ärsvårt, på vilket sätt människan är unik i djurvärlden i sitt sätt att samarbeta - en ökad förståelse för hur vi kan tillämpasamarbetsmekanismerna i en grupp

Presentationsteknik: Teoretiska övningar omfattar bland annat strukturering av ett budskap och en presentation,Kursens innehåll : vilka media vi har att tillgå för att nå ut till en publik samt vikten av kroppspråket. De praktiska momenten omfattar egnapresentationer. Alla kan träna upp sin förmåga att uttrycka sig engagerande, inspirerande och säkert, vare sig det handlar om attföreläsa inför en stor publik eller att framföra åsikter i en grupp. Genom improvisationsövningar lär du dig använda dina personligastyrkor medvetet för att bli mer självsäker, närvarande och uttrycksfull. Samarbete och relationsbyggande: Teori varvas medgruppövningar och vi går igenom samarbetets mekanismer och dynamik, hur vi kan påverka samarbetet i en grupp och hur detta serut i praktiken i er vardag som medlem i en forskargrupp. Genom att förstå och tillämpa de mekanismer som påverkar vårbenägenhet att samarbeta kommer vi att bli mer framgångsrika i våra relationer till andra människor, vare sig det gäller enprofessionell relation eller privat.

Gruppövningar, föreläsningar, handledning i grupp, muntliga presentationer, enskilt arbete.Arbetsformer : Presentationer och gruppövningar.Examination :

Obligatoriska moment: 1. analys av ett samarbetsproblem 2. gruppanalys och presentation avObligatoriska moment : mekanismerna bakom samarbete. Kompensation för eventuell frånvaro: skriftlig inlämningsuppgift motsvarande de missadekurstillfällena.

15 - 20Antal studenter : Urvalet sker på en sammanvägning av a) motiveringen till varför studenten vill genomgå kursen och b) hittillsUrval av studenter :

avlagd forskarutbildning, dvs halvtidskontroll, tid till planerad disputation, registeringsdatum.Välkommen att söka kursen i Social kompetens! Vi vill informera om att stor vikt läggs vid den personligaYtterligare information :

motiveringen i ansökan när kursplatserna fördelas och därför be dig lägga ner lite extra tid på att skriva några rader PÅ SVENSKAom varför den här kursen vore av betydelse för dig och dina doktorandstudier, vad du förväntar dig få ut av den, varför du tycker attsamarbete är viktigt för forskningen och dessutom något om dig själv och din forskning. Denna kurs ges på svenska och det är avavgörande betydelse att du behärskar språket i tal och skrift. (Kursen ges även på engelska.) Föreläsare på kursen är SofiaCzinkoczky, Carl-Adam Wachtmeister och Anna Hildenbrand Wachtmeister: Sofia Czinkoczky är skådespelare med stor erfarenhetav kurser i improvisationsteater och presentationsteknik. Sofia har tidigare arbetat som konstnärlig ledare på StockholmsImprovisationsteater. Sedan 1999 arbetar hon med utbildning och ger kurser i kommunikation, improvisation och kreativitet förföretag. Sofia brinner för att få människor att våga använda mer av sin inneboende kreativitet, vilket tydligt märks i hennes kurser ipresentationsteknik. Carl-Adam Wachtmeister är disputerad beteendebiolog med närmare 15 års erfarenhet av forskning ochundervisning om beteende hos människor och djur. Idag arbetar han som konsult och verkar både inom universitetsvärlden ochföretagsvärlden, med regelbundna uppdrag bl.a. för Karolinska institutet, Göteborgs universitet och Stockholms universitet.Carl-Adam har specialiserat sig på samarbete och kulturell förändring. Anna Hildenbrand Wachtmeister är disputerad vid KarolinskaInstitutet och certifierad ICC-coach. Hon driver idag eget företag med verksamhetsområdet förändring och utveckling inom olikabrancher och har många års erfarenhet som egen företagare och även som föreläsare. Undervisningen sker på Karolinskasjukhuset i Solna och i Gamla stan. Varmt välkommen! Samtliga frågor skickas till Anna Hildenbrand [email protected] mobil: 070-7890607

Kursansvarig : Kristina GemzellInstitutionen för kvinnors och barns hä[email protected]

Kontaktpersoner : Anna HildenbrandInstitutionen för kvinnors och barns hä[email protected]

Title : Social skills: Presentation techniques, cooperation and relationships




Särskild behörighet : After attending this cours the PhD student will: - have tools for presenting their research in a successfulKursens lärandemål :

manner - have gained an understanding of how an audience is influenced by for example our body language - have learned to makethe best out of him/herself as a speaker - have a deeper understanding of mechanisms promoting and reducing cooperationbetween individuals and within a group - understand why cooperation might be difficult and in which way humans are unique in theway we cooperate - understand more about how to apply the mechanisms of cooperation in a group

Presentation technique: Lectures on themes like body language and status. Practical sessions on bodyKursens innehåll : language, presentation, improvisation, and different techniques to make your presentation more interesting and help you delieveryour message. Everyone can improve their skills in expressing themselves in an inspiring, secure, and enthusiastic way, no matter ifthe purpose is to give a lecture in front of a big audience or to express your opinion within a group. With the help of someimprovisation exercises you will learn how to use your personal strengths in order to increase your self esteem. Cooperation andrelationships: Theory, economic games, discussions, and assignments will be mixed. You learn about the mechanisms anddynamics of cooperation; how you can influence cooperation in a group and how this can be translated to your every day work as amember of a research group. By understanding and applying the mechanisms which influence how prone we are to cooperate wewill become more successful in our relationships with other people, both professionally and in private life.

Group assignments, lectures, economic games, discussions, supervision in group, oral presentations, individualArbetsformer : assignments.

Oral presentation and individual assignments. Examination : Compulsory parts: 1. individual, written analysis of a cooperation problem 2. group assignment andObligatoriska moment :

presentation where the mechanisms behind cooperation are discussed Written assignments as compensation for missedcompulsory parts.

15 - 20Antal studenter : a) Personal motivation on why the doctoral student wishes to attend the course b) Date of half time control and Urval av studenter :

when dissertation is planned c) registration dateWelcome to apply for the course on Social Skills! We would like to inform you that we focus a lot on theYtterligare information :

personal motivation in the application when deciding who will participate in the course. Therefore we would like to ask you to spendsome extra time on writing something about why you are applying for this course, in which way it would be of value for yourself andyour doctoral studies, what you expect of the course, why you think cooperation is important in research and also something aboutyourself and your doctoral studies. This course is in English, including all lectures and assignments. (The course will also be given inSwedish.) Lecturers are Sofia Czinkoczky, Carl-Adam Wachtmeister and Anna Hildenbrand Wachtmeister: Sofia Czinkoczky is anactress with many years of experience in giving courses in improvisational theatre and presentation technique. Sofia has been headof Stockholms Improvisationsteater. Since 1999 she has been working in the field of education and giving courses incommunication, improvisation, and creativity for companies. Her passion is to make people dare using their innate creativity, whichalso show in her courses on presentation technique. Carl-Adam Wachtmeister did his PhD on behavioural biology and has about 15years of research and teaching experience in the field of human and animal behaviour. Today he is a senior consultant, withassignments in both universities and companies. In his work Carl-Adam is focusing on cooperation and cultural change. AnnaHildenbrand Wachtmeister did her PhD at Karolinska Institutet and is also a licenced ICF Executive and Leadership Coach, workingas a senior consultant in the field of business coaching, leadership development and cooperation within organizations. Schedule forthe course will be handed out on the first day of the course. Some of these days are scheduled for groupwork (half/full class) andsome are assigned for individual work.



Title : Basic Laboratory Safety




Experience of laboratory workSärskild behörighet : After successfully completing this course you as a student should be able to evaluate the risks associatedKursens lärandemål :

with experiments in the laboratory. The hazards could originate from chemicals, microbiological agents, blood/tissue and isotopes.You should also be able to identify the needs for personal protective equipment, routines for waste management and transport. Inaddition, you should be familiar with the regulatory framework that governs these topics, the basic needs of a safe laboratory, and beable to identify the chain of responsibilities.

The course aims at giving theoretical and practical aspects of laboratory safety.Kursens innehåll : The information will be given as lectures, group discussions, practical session and computer sessions during a totalArbetsformer :

of five days. The examination is based on individual written examination and a risk assessment.Examination :

Presence during all the scheduled activities are compulsory. Students can compensate for absenceObligatoriska moment : through individual assignments.


(2) your registration date as a PhD student at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KI in your personal profile and that you have ranked the courses you have applied for. Please observe:To this course you have to reply by December the 4th 2011 at the latest after getting a preliminary acceptance offer. Ytterligare information :

Kursansvarig : Roland MöllbyInstitutionen för mikrobiologi, tumör- och [email protected]

Kontaktpersoner : Jenny SjöbergUniversitetsfö[email protected]

karolinska Institutet i SolnaMiljöenheten, Berzelius väg 1317177Stockholm

Title : Human embryonic stem cells




Särskild behörighet : The objectives of this course are that at the conclusion of this course students should have a goodKursens lärandemål :

understanding of: ¿Folliculogenesis and Fertilization ¿Pre implantation Embryology ¿Criteria of selected or scoring the blastocystsfor isolation of ICM ¿Derivation methods of hESCs ¿Culture condition of hESCs ¿Main components of the culture system (culturemedia, tissue culture plastics, gases, incubators, workstations, laboratory environment, input materials) ¿Physical-chemicalproperties of culture system (osmolarity and pH of culture media, temperature, light levels) and how they can be influenced ¿Nutritional requirements of the blastocyst and hESCs ¿Functional characteristics of different tissue culture incubators ¿Theinfluence of the laboratory and clinic environment on hESCs ¿Developmental milestones ¿Students should know the prospectivepossibilities of having a good culture system ¿Students should be aware of the general aspects and implication of the stem cellsresearch and the potentiality that these represent for clinical application ¿Characterization of the embryonic stem cells and theimportance of the pluripotency of these cells ¿The different differentiations assay on stem cells and what is ongoing in this field ¿Theimmunorejection problem and the production of isogonics embryonic stem cells by somatic cell nuclear transfer or therapeutic clone(SCNT) ¿The pluripotence induction of somatic cell by transduction, (the iPS cells) ¿Finally the students will improve their capacityto produce coherent, logical and concise explanations of data and concepts - both written and oral, through consideration of thecourse material. ¿Students will also develop their ability to criticize scientific literature related with hESC technology andreproduction physiology in a constructive and informed fashion ¿Be aware of potential development of hESC technology in thefuture.

Divide in lectures and laboratory work 1. Embryology ¿theory¿ (lectures) 2.Culture system (lectures) 3.HumanKursens innehåll : Embryonic Stem cells culture (lectures) 4. Characterization (lectures) 5. Laboratory demonstrations 6. Genetics (lectures) 7.Induction of different cell types (lectures) 8. Reprogramming (lectures) 9. Stem cells therapy and challenge (lecture) 10. Future inhuman embryonic stem cells (lecture) Course test, evaluation, discussions, examination and closing of course:

The course (human embryonic stem cells) runs for one week every year, with lectures and laboratory practicalArbetsformer : demonstrations.

Writing individual- examenExamination : The laboratory parts are obligatory. If absent at laboratory activity; student should present a literature workObligatoriska moment :

related with the subject of the missing activity12 - 24Antal studenter :

Selection will be based on motivation.Urval av studenter : The course will be given at Karolinska University hospital, Huddinge.Ytterligare information :

Kursansvarig : Jose InzunzaInstitutionen för biovetenskaper och näringslära08-524 810 [email protected]

Hälsovägen 7, Novum

141 86Stockholm

Kontaktpersoner : Jose InzunzaInstitutionen för biovetenskaper och näringslära08-524 810 [email protected]

Hälsovägen 7, Novum

141 86Stockholm

Title : Redox regulation, oxidative stress and selenoproteins



ForskarnivåNivå : Department of Medical Biochemistry and BiophysicsKursansvarig institution :

Särskild behörighet : After the course, each student should have acquired the following knowledge: - Good knowledge ofKursens lärandemål :

structure-function relationships for the major low molecular-weight antioxidant compounds found in cells (GSH, Ascorbate,tocopherol) - Good knowledge of the major antioxidant and redox regulatory systems and redox sensitive signaling pathways(glutathione-dependent systems, thioredoxin systems, Nrf2/Keap1, Yap1, peroxiredoxins, methionine sulfoxide reductases,peroxidases, catalases, superoxide dismutase, NADPHoxidase, oxidative burst, PTP regulation, cyt c, ASK-1) - Good knowledge ofselenoprotein synthesis and selenoprotein function After the course, each student should also have the skill to present and discuss aredox-regulated research project at a level generally expected for presentations held at international cutting-edge conferences in thesubject.

The course is planned as a joint training encompassing an international exchange graduate course, withKursens innehåll : students and lecturer's primarily recruited from Karolinska Institutet and the Redox Biology Center of the University of Nebraska inLincoln (UNL), Nebraska, which is an NIH COBRE (Center of Biological Research Excellence) initative focused on research in redoxbiology. The course is planned to be annually held and will have the following major components: - Students from both UNL andKarolinska Institutet - Lecturers from both Karolinska Instituet and UNL - Held each spring, every second year at Karolinska Institutetand every second year at UNL Planned lectures will contain subjects such as the following examples: - "Glutathione S-transferasesin redox regulation and glutathione dependent catalysis" - "Nitric oxide (NO) signaling in relation to redox state" - "Calcium signalingin oxidative stress and in relation to apoptosis" - "Glutaredoxin and thioredoxin systems" - "The concepts and effects of redox cyclingand selenoprotein reactivity" - "Selenoproteomes and dedicated Cys- and/or Sec-dependent redox systems" - "Using proteincrystallography to probe the function of redox active enzymes" - "Redox activities of proline in a cellular context" - "The effects ofmetals on metabolism and oxidative stress in human disease" - "With the sight on redox: glutaredoxin and thioredoxin systems in theocular lens and their relation to cataract" - "Redox control of ion channels" - "How oxygen can be sensed in the carotid body" -"Mitochondrial production of reactive oxygen species in relation to human disease" s

The course it is built upon a pedagogic framework of discussions between graduate students in redox biology withArbetsformer : leading experts in the field, combined with cutting-edge lectures, training in oral presentation, career counceling sessions and awritten exam for control of detailed basic knowledge in redox biology. It is the firm belief of the course organizers that this pedagogicframework should well support the students to obtain the learning objectives of the course. It should furthermore help the students toprepare for their next level of a career beyond the doctoral examination. The type of teaching will be: - Morning sessions withlectures in basic concepts as well as cutting-edge front-line research findings in the field - Afternoon sessions with studentpresentations followed by discussions between lecturers and students - Career discussions and future perspectives in the field ofredox biology

The student skills are examined as follows: - Evaluation of the degree of participation in student-lecturer discussionsExamination : and the level of initiated comments and questions during those discussions (grade pass/not pass) - Evaluation of the presentation ofthe student's own project (grade pass/not pass) - Results at written examination (at least 60% right answers for the grade of pass)Attendence during compulsory parts of the course as well as the grade of "Pass" in all three parts of the examination must befulfilled for a final grade of "Pass".

Absence from any part of the course (lectures, student presentations, career discussions, exam and awardObligatoriska moment : ceremony) is generally not accepted but could in special cases be compensated by an individually tailored additional discussion anda special written examination organized by the course committee.

10 - 20Antal studenter : 1st priority: Doctoral students in redox biology before half-time; 2nd priority: beyond half-time; 3rd priority:Urval av studenter :

other research fields, before half-time; 4th priority: other fields beyond half-time Within each group, priority is according to motivationfor the course and scientific merits. Include a short project description when applying.

This course provides joint training encompassing an international exchange graduate course, withYtterligare information : students and lecturer's primarily recruited from Karolinska Institutet, Harvard Medical School, and Redox Biology Center of theUniversity of Nebraska in Lincoln (UNL), Nebraska, which is an NIH Center of Biological Research Excellence. The course is ratherdemanding and intense. The course is held annually and has the following major components: - Students from UNL, HarvardMedical School, and Karolinska Institutet - Lecturers from Karolinska Instituet, Harvard Medical School and UNL - Course is held inthe spring and rotates every year between the participating institutions - For 2012, the course will be held in Stockholm on June11-15 and hosted by Karolinska Institutet.

Kursansvarig : Elias ArnérInstitutionen för medicinsk biokemi och [email protected]

Kontaktpersoner : Elias Arnér

Institutionen för medicinsk biokemi och [email protected]

Title : Modern methods for DNA sequencing.



ForskarnivåNivå : Department of Cell and Molecular BiologyKursansvarig institution :

-Särskild behörighet : After the completed course, the students will be able to understand and describe the technology behind theKursens lärandemål :

major DNA sequencing platforms available today, their strengths and limitations. Furthermore, the students will be able to describethe most important applications and relate and apply them to the students' own research.

The course covers the following topics: The history of DNA sequencing. Introduction to modern DNAKursens innehåll : sequencing. Practical considerations, cost and dealing with a deluge of data. Applications: RNA sequencing, ChIP sequencing andmetagenomics. Future technologies and applications.

The learning activities on the course consist of lectures by invited speakers, and a site visit to a sequencingArbetsformer : laboratory. In addition, the students will be supervised in the preparation of presentations on modern DNA sequencing methods tobenefit their own research.

Oral examination in conjunction with the presentation of individual student projects.Examination : All lectures are compulsory. Absence from the obligatory moments is compensated according to theObligatoriska moment :

instructions of the course director.5 - 10Antal studenter :

The selection is based on the relevance of the course content for the doctoral project, and the personalUrval av studenter : motivation to attend the course.

The course is organized at the KI Solna Campus. The course director is Dr. Sten Linnarsson (MBB) andYtterligare information : the main examiner is Dr. Rickard Sandberg (CMB/Ludwig).

Kursansvarig : Matti NikkolaInstitutionen för cell- och molekylärbiologi

[email protected]

Kontaktpersoner : -

Title : Bioinformatics for cell biologists




-Särskild behörighet : After the completed course, the students will be able to utilize basic bioinformatics resources and tools, applyKursens lärandemål :

and integrate current, advanced computational biology methods in their research, and to make use of publicly availablegenome-wide sequencing data sets.

The course covers the use of most common bioinformatics resources such as public data bases and tools forKursens innehåll : sequence analysis. Practical excercises and discussions bridge sequence analysis to cellular function.

The learning activities on the course consist of lectures and practical computer excercises. In addition, the studentsArbetsformer : will be supervised in the preparation of presentations on bioinformatics to benefit their own research.

Formative examination with practical computer excercises. Summative oral examination in conjunction with theExamination : presentation of individual student projects.

The computer excercises are obligatory. Absence from the obligatory moments is compensated accordingObligatoriska moment : to the instructions of the course director.

10 - 14Antal studenter : The selection is based on the relevance of the course content for the doctoral project and the personalUrval av studenter :

motivation letter to attend the course.The course provides essential, practical knowledge about computational methods in biology with focus onYtterligare information :

developmental biology. The course is organized at the KI Solna campus. The course director is Dr. Rickard Sandberg.


[email protected]

Kontaktpersoner : -

Title : Management and research




None.Särskild behörighet : After attending the course the phd student should have: - a theoretical understanding of the effect we haveKursens lärandemål :

on people we work together with, for example through our way of acting and how others effect us - practical experience of how ourbody language affects our collegues and people in our surroundings - gained knowledge about management and exercise of powerout of a historical perspective and what we can expect of the future in the same area - a deeper understanding of mechanismsbuilding and breaking down cooperation betwen individuals or members of a group - understanding of moral considerations inleadership - gained knowledge about the basics of negociation techniques - learnt about experiences from leaders in business aswell as research

Today, research is contucted in groups and networks - nationally or worldwide. The work and responsibilities ofKursens innehåll : a research leader has many similarities with that of a leader within different areas of business. Never the less, education in this areais often neglected in the world of research. The aim of this course is to inspire the participants to continue learning within this veryimportant field and also to create insight on the mechanisms creating a more successful social behaviour - both as a research leaderand as a member of a research group. During the seminar series a number of speakers and lecturers with interesting and relevantknowledge and experience will talk about managment, leadership, social skills, presentation techniques, cooperation, ethics andmore.

Lectures, interactive seminares, practical exercises, log book writing.Arbetsformer : Log book and group assignment.Examination :

Individual assignment.Obligatoriska moment : 10 - 15Antal studenter :

1) motivation 2) planned dissertation date 3) half time seminar dateUrval av studenter : Lecturers planned for 2011: Åsa Nilsonne: Mindfulness. Professor medical psychology, writer andYtterligare information :

therapeut (KBT) Anders Wendelheim: Creating trust in a group, group processes and change. PhD in psychology Ian Wachtmeister:Leadership in politics and business. Business manager, politician, writer Jan Söderqvist: Leadership in the future. Journalist andwriter Johan Holm: Management and leadership in a historical perspective. PhD in history. Marc Bygdeman: Experience as aresearcher and clinician. Professor emeritus, head of clinic, head of WHO:s center for reproduction at KS, hedersledamot av RoyalCollege of Obstetrics and Gynecology och American College of Obstetricians and Gynecologists och har tilldelats Kungensguldmedalj för sina insatser inom forskning och utveckling. M. Bygdeman is author to more than 400 scientific papers. SofiaCzinkoczky: Practical exercise and improvisation on social status and body language. Actress with many years of experience onpresentation techniques. Carl-Adam Wachtmeister: "Mechanisms behind cooperation" PhD in behavoural biology focusing onfinancial psychology and cooperation. Richard von Plauen: How to be a leader - ethical considerations. Civ. ek. från HEC i Paris,filosofi på Ecole Normale Supérieure. Anna Hildenbrand Wachtmeister: "Coaching is a way to successful leadership" PhD fromKarolinska Institutet and licenced ICF executive coach. Johan Lagerbielke: Negociation techniques and communication. Researcherfinancial psychology, consultant in negociation techniques. The course will be given in English on Thursdays 18-21 at KarolinskaUniversity Hospital Solna.



Title : Scientifically evaluated interventions in suicide prevention




Särskild behörighet : Upon completing the course the student should: (1) be able to show in-depth knowledge of concepts andKursens lärandemål :

methods in research on the prevention of mental ill-health and suicide in populations and vulnerable population subgroups; (2) beable to critically reflect on the relevance of different scientific subdisciplines and of quantitative and qualitative methods whenplanning, carrying out, and interpreting results in population-based research;

Prevention of mental ill health and suicide; scientific contributions to understanding sucide; methodologicalKursens innehåll : issues in mental health research.

Lectures, seminars with discussions of students' own projectsArbetsformer : In addition to participating actively in the course, each student is required to present his or her own ongoing orExamination :

planned research in a seminar during the course week. All lectures and seminars are obligatory. Absence from a lecture or seminar may be compensated by aObligatoriska moment :

written assignment, on agreement with the course leader. 6 - 24Antal studenter :

Applicants will be prioritized on the basis of the content of their research and of their personal writtenUrval av studenter : motivation.

The specific theme this year is "evidence in mental health research". Lecturers and discussants of studentYtterligare information : projects include researchers from NASP and invited international scholars from different subdisciplines of suicidology and suicideprevention. Full-time active participation in the course is mandatory. Students are given time for a short presentation and discussionof their planned or ongoing research.

Kursansvarig : David TitelmanInstitutionen för folkhälsovetenskap

[email protected]

Kontaktpersoner : Birgit Frisen-AnderssonInstitutionen för folkhälsovetenskap

[email protected]

Asli KulaneInstitutionen för folkhä[email protected]

Title : Statistical modeling and inference using likelihood




Särskild behörighet : After successfully completing this course you as a student are expected to be able to: - presents the role ofKursens lärandemål :

likelihood in a whole range of statistical problems, from a simple comparison of two accident rates to complex studies. It will beemphasized that likelihood is not simply a device to produce an estimate, but more importantly it is a tool for modeling. - present keyapplications of likelihood modelling, including the generalized linear models, estimating equations, survival analysis and generalizedlinear mixed models. - derive and implement computational algorithms such iterative weighted least-squares algorithm. - understandand derive key theoretical results such as sufficiency and the asymptotic theory of the likelihood ratio statistic.

(From the chapter from the textbook) 1.Introduction, schools of inference: frequentist, Bayesian, FisherianKursens innehåll : (chapter 1) 2.Definition of likelihood, examples, Fisher information, standard errors and Wald statistics, invariance principle (chapter2) 3.Sufficiency and minimal sufficiency, profile likelihood, calibration in multi-parameter space (chapter 3) 4.Basic models: binomialand Poisson models (chapter 4) 5.Basic models: continuous models, Box-Cox transform (chapter 4) 6.Bias and variability ofestimates, confidence interval and densities (chapter 5) 7.Bootstrapping, exact inference (chapter 5) 8.Regression models: normal,logistic, Poisson, deviance (chapter 6) 9.Regression models: exponential family, GLM, IWLS algorithm, location-scale family(chapter 6) 10.Score function and Fisher information (chapter 8) 11.Large sample results: consistency and normality of MLE(chapter 9) 12.Distribution of likelihood ratio, higher order approximation (chapter 9) 13.Nuisance parameters, marginal andconditional likelihood (chapter 10) 14.Markov chains, censored survival data, hazard regression (chapter 11) 15.Poisson pointprocesses, discrete time processes (chapter 11) 16.EM algorithm, examples (chapter 12) 17.Robustness of likelihood (chapter 13) 18.Estimating equations, quasi-likelihood, robust estimation (chapter 14) 19.Random and mixed effects models (chapter 17) 20.Generalized linear mixed models (GLMM) (chapter 17)

The course is mainly based on a series of seminars given by the students, where they present (i) materials basedArbetsformer : on reading materials and review of literature and and (ii) exercises based on analysis of real data sets using statistical software, (iii)exercises not requiring statistical software and (iv) group discussions In doing the exercises and preparing their seminars thestudents work in groups. The seminars are one afternoon each week in 20 weeks. Then the students get home assignments that willtake 2days for the students to do.

To pass the course, a student has to show that the learning outcomes have been achieved. The course grade isExamination : based mainly on the oral presentations that the student makes, and also on a final project at the end of the course period, where thestudents have to write a report.

Weekly attendance is compulsary. Students that miss attendance will make a presentation at a separateObligatoriska moment : occasion.

10 - 15Antal studenter : Relevance of the course for the research program. No documentation is required. A written statement detailingUrval av studenter :

successfully completed courses and practical experience will suffice, covering at least: one year of calculus, including partialderivatives and multiple integrals, introductory theory of probability and statistics, applied statistics and experience with statisticalcomputing software such as Splus or R, one term of linear or matrix algebra¿.

The first meeting is 6 February 2012 at the Department of Medical Epidemiology and Biostatistics, NobelsYtterligare information : väg 12A, Karolinska Institutet.

Kursansvarig : Yudi PawitanInstitutionen för medicinsk epidemiologi och biostatistik

[email protected]


Title : The Yin and Yan of endocytosis in health and disease




Särskild behörighet : After the course, the students will be able to describe the molecular mechanisms that regulate intracellularKursens lärandemål :

trafficking. The student will also enhance their analytical and critical thinking to discuss and understand advanced problems beyondwhat is found in text books, and evaluate the relevance of the topics presented in the context of their own research activities andPhD studies.

The course will cover different aspects of the cellular membrane endocytosis and intracellular trafficking, suchKursens innehåll : as: the basic molecular mechanisms controlling plasma membrane retrieval, molecular regulation of vesicular trafficking. Part of thecourse will focus on the role of endocytosis in developmental biology, and the mechanisms by which viruses and bacteria hijack theendocytic pathway to promote their entry, replication and immune evasion in the host during infection.

The pedagogic learning activities on the course consist of cathedral lectures, student presentations, followed byArbetsformer : group discussions and research seminars.

The students are examined individually. As assessment the student will write an assay on one of the subjects withinExamination : the scope of the course. The assays will be evaluated by the course organizers.

Attendance to all the activities of the course and the written examination are mandatory. Absence fromObligatoriska moment : mandatory parts of the course will be compensated by other activities after discussion with the course leaders.

10 - 25Antal studenter : Selection is based on the relevance of the course content to the doctoral project, and the personal motivationUrval av studenter :

written in the course applicationThe course is full time and it takes place in the seminar room A216 at the Department of Cell andYtterligare information :

Molecular Biology at KI, entrance Berzelius v 35. The course faculty includes invited speakers from different universities in Europe,and local faculty. The speakers are recognized leaders in their respective fields. The course co-directors are Dr. Teresa Frisan andDr. Oleg Shupliakov at Karolinska Institutet. Email [email protected].


[email protected]

Kontaktpersoner : -

Title : The Yin and Yan of endocytosis in health and disease




Särskild behörighet : After the course, the students will be able to describe the molecular mechanisms that regulate intracellularKursens lärandemål :

trafficking. The student will also enhance their analytical and critical thinking to discuss and understand advanced problems beyondwhat is found in text books, and evaluate the relevance of the topics presented in the context of their own research activities andPhD studies.

The course will cover different aspects of the cellular membrane endocytosis and intracellular trafficking, suchKursens innehåll : as: the basic molecular mechanisms controlling plasma membrane retrieval, molecular regulation of vesicular trafficking. Part of thecourse will focus on the role of endocytosis in developmental biology, and the mechanisms by which viruses and bacteria hijack theendocytic pathway to promote their entry, replication and immune evasion in the host during infection.

The pedagogic learning activities on the course consist of cathedral lectures, student presentations, followed byArbetsformer : group discussions and research seminars.

The students are examined individually. As assessment the student will write an assay on one of the subjects withinExamination : the scope of the course. The assays will be evaluated by the course organizers.

Attendance to all the activities of the course and the written examination are mandatory. Absence fromObligatoriska moment : mandatory parts of the course will be compensated by other activities after discussion with the course leaders.

10 - 25Antal studenter : Selection is based on the relevance of the course content to the doctoral project, and the personal motivationUrval av studenter :

written in the course application. The course is full time and it takes place in the seminar room A216 at the Department of Cell andYtterligare information :

Molecular Biology at KI, entrance Berzelius v 35. The course faculty includes invited speakers from different universities in Europe,and local faculty. The speakers are recognized leaders in their respective fields. The course co-directors are Dr. Teresa Frisan andDr. Oleg Shupliakov at Karolinska Institutet. Email [email protected].


[email protected]

Kontaktpersoner : -

Title : Basic immunology




Särskild behörighet : To understand basic principles of innate and adaptive immunity and how different components of theKursens lärandemål :

immune system cooperate. To be able to relate, compare and understand experimental aspects of immune-related disease in aclinical perspective. To adapt knowledge gained of the function of the immune system by being able to analyze and discuss animmunological/clinical case (group project). To present the group project and discuss the results as well as work in pairs with clinicalcases.

The course is separated into two parts. In part 1 we discuss basic immunological mechanisms within the innateKursens innehåll : and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defence against infection, autoimmuneand allergic disease or transplantation. Part 1: Introduction An overview of the immune system T cells B cells Antigen-presentingcells Innate vs adaptive immune responses Methods to study immune reactions. Part 2: Immune defence against bacterial andviral infections Primary immunodeficiencies Autoimmune disease Allergy Vaccination Clinical Immunology Transplantation Tumour Immunology Questions and discussions Presentation of projects.

The course is given full-time during a total of six days separated into two parts. The teaching is mainly inArbetsformer : lecture/seminar form but also includes project work studying cases individually and pairwise, as well as in small groups. The groupprojects are then presented orally on the last day of the course. The project work requires studies between the two course parts,including meetings with mentors. Course literature (Abbas) and cases are handed out at the course start. An immunological quiz isconnected to the different chapters in the book so that the student will be able to digest the relatively big material. The course isdesigned so that clinically active doctors will be better able to combine it with work in the clinic (Mondays and Fridays contain noscheduled course work) .The purpose of dividing the course into two parts is that the participants should have time to thoroughlystudy the literature from part 1 (fundamental immunological mechanisms) before teaching of the applied immunology in part 2 starts.Considering the substantial literature requirement plus the cases and project work, we estimate that an extra 32h of study is needed,which is not included in the schedule.

Web-based exam on the course content. Oral presentations of small-group project work. At this occasion specialExamination : attention is given to that all students are actively participating. The clinical cases are examined by written reports.

Project work and attendance at the project presentation is compulsory as well as work with two clinicalObligatoriska moment : cases. In the case of absence a separate occasion is organized with presentation for the course organizers. The web-based exam ismandatory.

12 - 30Antal studenter : Selection of students is based on 1. Date of acceptance as doctoral student 2.Motivation to attend the course.Urval av studenter :

The course is separated into two parts (3+3 days). In part 1 we discuss basic immunological mechanismsYtterligare information : within the innate and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defence againstinfection, autoimmune and allergic disease or transplantation. Part 1: Introduction An overview of the immune system T cells Bcells Antigen-presenting cells Innate vs adaptive immune responses Methods to study immune reactions. Part 2: Immune defenceagainst bacterial and viral infections Primary immunodeficiencies Autoimmune disease Allergy Vaccination Clinical Immunology Transplantation Tumour Immunology Questions and discussions Presentation of projects

Kursansvarig : Jan WahlstromInstitutionen för medicin, [email protected]

Lungforskningslab L4:01Karolinska Universitetssjukhuset, Solna171 76Stockholm

Kontaktpersoner : -

Title : Functional Fluorescence Microscopy Imaging (fFMI) in biomedical research




Särskild behörighet : At the end of the course the student should be able: 1. to use fundamental aspects of molecular structure toKursens lärandemål :

describe molecule (matter) interaction with light (electromagnetic radiation) and the emission of fluorescence, and to use thisknowledge to discuss fluorescent properties of a fluorophore and different labeling strategies. 2. to understand the fluorescenceimaging instrumentation, to define elements of a fluorescent microscope and to describe instrumentation properties in terms ofsensitivity. 3. to describe the theoretical background behind fluorescence based methodologies for studying molecular interactionsin live cells. Discuss pros and contras in relation to the biological problem studied. 4. to specify instrumental requirements and todesign a fluorescence imaging assay for a biological problem of interest. 5. to apply a specific labeling strategy and perform a livecell fluorescence imaging assay. 6. to document experimental work in accordance with Good Laboratory Practice (GLP) guidelines. 7. to communicate the results in written and oral form. 8. to discuss the adequateness of the methodology used in the scientificliterature concerned.

Fluorescence microscopy and associated techniques are becoming indispensable research tools forKursens innehåll : investigating molecular mechanisms of biological processes. Versatility of fluorescence based methodologies comes from themultifaceted possibility to characterize fluorescence emission by position, intensity, wavelength, lifetime and polarization. Thesemethodologies bring new biological insight at an unprecedented rate and are of crucial importance for the development of lifesciences. The course covers the following topics: Luminescence and the nature of light (Fluorescence, Phosphorescence, Lightscattering, Rayleigh-Tyndall scattering, Raman scattering); Fluorescent markers and their photophysical properties (Organicfluorescent dyes for covalent conjugation (Rhodamine 6G, Alexa dyes, Cyanine dyes); Quantum dots; Intrinsically FluorescentProteins (Aequorea victoria (GFP, YFP), Discosoma coral (DsRFP) and Montipora (Keima) families); Selectively binding andintercalating dyes (DiI, DraQ 5). Labeling strategies for biomedical application. Instrumentation for fluorescence imaging (Lightsources, Wavelength selection, Detectors, Read-out devices, Sample holders, Problems of high blank values, Cuvettes, Solventsand Reagents, Other contaminants); Quantitation and Sensitivity (Instrumental sensitivity, Method sensitivity, Absolute sensitivity);Factors affecting quantitative accuracy (Adsorption, Photo-decomposition, Oxidation, Temperature, pH, Inner-filter effects,Quenching); Fluorescence based methodologies for studying molecular interactions in live cells (FRET, FLIM, FRAP).Single-molecule detection (Quantitative APD imaging, FCS and FCCS). Non-linear microscopy (Multi-photon excitation, STED).Spatially resolved fluorescence imaging (STORM, PALM).

The course includes lectures, laboratory sessions, discussion sessions and a project work.Arbetsformer : The final assignment consists of a written project report (5 pages) and an oral presentation of the project report (15Examination :

min). All sessions are compulsory. Please report any absence to the course leader in advance by e-mail.Obligatoriska moment :

Absence from any part of the course (lectures, laboratory sessions, discussion sessions and exam) is generally not accepted butcould in special cases be compensated by an individually tailored additional module and a special written examination organized bythe course committee.

8 - 12Antal studenter : This is an advanced course on fluorescence microscopy imaging. Number of participants is limited to 12.Urval av studenter :

Priority will be given to applicants who can concisely (max 250 words) show in their application an urgent need to begin theirindependent work with live cells fluorescence imaging. Ytterligare information :

Kursansvarig : Vladana VukojevicInstitutionen för klinisk [email protected]

CMM L8:01

17176Stockholm

Kontaktpersoner : -

Title : Observation och video som forskningsmetod inom vårdområdet




Särskild behörighet : At the end of the course the student should -know how to do direct/naturalistic observations within aKursens lärandemål :

deductive approach by developing and using an observation protocol - know how to do participatory and not participatoryobservations within an inductive approach - know how to use video-observation as a means for data-collection - know how to test forvalidity and reliability - have an understanding of different methods used (quantitative and qualitative) for analyzing data generatedfrom the observations.

Developing and testing a protocol which can be used for both naturalistic observations and videotapes orKursens innehåll : performing video-observation which should be transcribed into text and further analyzed; testing observed data for validity andreliability. The content of the course is built on how to investigate interaction between people exemplified from a caring situation.

Lectures, seminars and individual assignments/project workArbetsformer : The student will in her/his project work and with the individual assignments demonstrate her/his knowledge andExamination :

ability to use naturalistic and video observations as a means for investigate interaction in a caring situation.The course in its whole needs active involvement of the student through participation in the various typesObligatoriska moment :

of learning.10 - 20Antal studenter :

Företräde ges till doktorander vid Nationella Forskarskolan i vårdvetenskap. Urval sker utifrån sökandesUrval av studenter : motivering till att gå kursen.

Kursdatum 25-27/1, 6-7/2, 6-7/3 samt 26-27/3 2011 är schemalagda. Där emellan tillkommerYtterligare information : hemuppgifter.

Kursansvarig : Kyllike ChristenssonInstitutionen för kvinnors och barns hä[email protected]

Retziusväg 13A

171 77Stockholm


Title : Positron emission tomography imaging of the CNS




Särskild behörighet : On completion of the course the PhD students will understand the principles of positron emissionKursens lärandemål :

tomography, the methodology of neuroreceptor quantification, and the application of imaging biomarkers in the CNS area. Thestudents will be able to describe how PET can be applied to a clinical research question.

This course will cover the basic principles of positron emission tomography, development of radioligands andKursens innehåll : CNS drugs, and quantification of neurotransmitter systems. At an applied level, the course will focus on selected imaging biomarkersto study the pathophysiology and treatment of major CNS disorders such as schizophrenia, depression, attention-deficit hyperactivitydisorder and neurodegenerative disorders such as Alzheimer´s and Parkinson´s disease. Specific attention will be given to newapproaches for diagnostic purposes. Integration with other imaging modalities such as MRI will also be covered.

The course will include lectures in the morning and Jigsaw sessions or Group discussions on selected papers fromArbetsformer : the literature in the afternoon. An "hands-on" session on the analysis of PET data will be also organized.

Written exam (the student will write an essay describing the application of PET in a CNS-research area. The topicExamination : will be assigned. Review of the literature is allowed) and group discussions.

The participation in the lectures, the group discussions and the exam is compulsory. Special reasons ofObligatoriska moment : absence can be discussed with the course organizers. The compensation for the absence from any part will be done in the form of awritten assignment.

10 - 20Antal studenter : Priority will be given to students involved in neuroscience research and will be based on the date ofUrval av studenter :

registration as a doctoral student.The course will be given at the Z8 Building of the Karolinska Hospital, Solna. Lecturers will be from theYtterligare information :

Karolinska Institutet PET Centre and from the Turku PET Centre and are world expert within the field of molecular imaging with PET.

Kursansvarig : Andrea VarroneInstitutionen för klinisk [email protected]

Karolinska Hospital, Psychiatry BuildingFoUU-PET, R5:0217176Stockholm

Kontaktpersoner : Anton ForsbergInstitutionen för klinisk neurovetenskap

[email protected]

Title : Antigen presentation and T cell activation




Särskild behörighet : By completing this course the students will be able to account for different types of antigen capture andKursens lärandemål :

processing, antigen presentation pathways (MHC class I and II), the CD1 system, peptide/lipid/glycolipid presentation, immuneevasion of antigen presentation in terms of processing and presentation on cell surface and altered peptide ligands, as well as interms of some microbial dissemination strategies. Students will also have aquired knowledge about T lymphocyte recognition ofantigen-presentation with strong focus on lymphocyte and target cell apoptosis/survival signaling pathways within the cells. Thestudents will also have aquired knowledge about T cell activation and the effects of this at specific situations such as after stem cellor organ transplantation as well as mechanisms behind T cell mediated Autoimmunity.

Course Syllabus, Review articles and specific papers related to the lectures are distributed prior to the course.Kursens innehåll : The following will be covered during the course. Antigen capture (including endocytosis, phagocytosis) and some immune evasionstrategies related to this. This will be followed by a thorough walk-through of the antigen presentation pathways, both MHC class Iand II. Terms like altered peptide ligands, cross presentation, TCR recognition, allogeneic T cell activation, and NK cell receptors willbe covered. After this microbial immune evasion targeting antigen presentation pathways will be discussed and presented. The CD1system, presentation of lipids, glycolipids (including microbial interference, presentation to lymphocytes such as CD1 restricted Tcells and NKT Cells, lymphocyte mediated regulation of antigen presentation) will also be discussed. It will be finished off bycovering T cell activation and its effect after stem cell and organ transplantation and T cell mediated autoimmunity: Results ofantigen presentation to effector cells, with focus on T lymphocyte and target cell apoptosis and survival; signaling pathways andnetwork within the cells. Ending with a written exam and a small group work

The course will be based on lectures, as well as extra time for follow up discussions. In addition a smaller groupArbetsformer : work will enable the students to gain deeper knowledge in a small area of interest. The students are also given literature (see below)in order to prepare for the lectures and discussions.

Written Exam and a group work. The written examination will ensure that everybody takes active part as well as helpExamination : the students to clarify their gained knowledge.

All lectures and group sessions are considered mandatory. Missed events should be compensated for withObligatoriska moment : a written report on the subject.

10 - 40Antal studenter : In case of many applicants the admission is going to be ranked after motivation in first hand. Urval av studenter :

Ytterligare information :

Kursansvarig : Michael UhlinInstitutionen för mikrobiologi, tumör- och [email protected]

Kontaktpersoner : -

Title : Practical Proteomics



ForskarnivåNivå : Department of Oncology-PathologyKursansvarig institution :

biomedical education required (B.Sc. or M.Sc.), no special requirementsSärskild behörighet : After the course, the students will have an overview of modern proteomics technologies and will be able toKursens lärandemål :

perform by themselves 2D gel electrophoresis and MALDI TOF mass spectrometry (peptide mass fingerprinting). This course willallow the students to be qualified for an independent work with proteomics instrumentation.

The course will include lectures, seminars and practical training. Lectures will be delivered by scientists activelyKursens innehåll : working in proteomics. The significant part of the course will be devoted to a practical training of students in proteomicstechnologies. The course will consist of two blocks. The first is lectures about proteomics technologies and applications. The secondblock will contain practical training in experimental proteomics, such as protein separation in 2D-GE and protein identification byMALDI TOF mass spectrometry. For the first block, all students will attend lectures and seminars with discussions. For the secondblock, the students will be divided in groups of 3 to perform experimental training. The course will be concluded with a presentationof experimental projects performed by the students as a training in proteomics, and a summarizing discussion about results andopinions about the course.

The course will include lectures, seminars with discussions between students and lecturers, work with literature andArbetsformer : practical training.

Written examination, which will be designed in a way to ensure that the learning outcomes are reached. Examination : Presentation of results of experimental training: each student will have to present generated by her/him 2D gels and presentpersonally performed identification of proteins by MALDI TOF mass spectrometry. After written examination and presentation ofresults of training, discussion with students will take place to ensure that all objectives of the course have been achieved.

Lectures, seminars and practical training sessions are compulsory. Absence from compulsory parts will beObligatoriska moment : compensated according to instructions by the course organizer; lectures - by a written review of a missed subject, seminars - bydiscussion with the course organizer or lecturers, and practical training - by experimental work and a written report.

10 - 15Antal studenter : Three criteria will be applied: motivation in the application, requirement of proteomics technologies for a PhDUrval av studenter :

study of a student, and training in biochemistry and good basic knowledge in chemistry and physics. Course will be given during two weeks, full time. Start date is Monday the 2nd of April, and finish at theYtterligare information :

13th of April. lectures ¿Seminar Room/Jonkammaren (Z5:02), Practical training ¿ Laboratory at KBC, Z5:02

Kursansvarig : Serhiy SouchelnytskyiInstitutionen för [email protected]

KBC, Z5:01, KS Solna

17176Stockholm

Kontaktpersoner : Serhiy SouchelnytskyiInstitutionen för [email protected]

KBC, Z5:01, KS Solna

17176Stockholm

Title : The symbiotic concept: autoimmunity and tumorimmunity




Biology, genetics, biochemistry at BSc level or comparable studies.Särskild behörighet : At the end of the course the participant should be able to: 1) Discuss the principal immune tolleranceKursens lärandemål :

mechanisms at cellular and molecular levels. 2) Compare the function of tolerogenic mechanism in health and autoimmune diseaseand during the tumor progression. 3) Choose the right experimental system in vivo (animal models) and ex vivo (experimentaldesign, patients and control individual cohort recruitment) to comparatively analysis of tolerogenic mechanism operating in healthyand pathological conditions 4) Understand the principal strategy used in clinical development to induce immune tolerance inautoimmune disease patients and break tumor induced tolerance in neoplastic disease patients.

The Course will overview the most recent acquisition in the field of the immuno regulation with special emphasisKursens innehåll : on the tolerogenic mechanisms. How to translate basic knowledge on immuno tolerance in clinical field will be discussed as well.The topics covered will be cell biology, genetics, immunology, internal medicine and tumorbiology. The student will learn how theimmune tolerance positive and negative modulation is a mechanism behind the tumor progression or autoimmune disease. Keyconcept of the experimental technique will be introduced in theory and with practical exercitation as multiparametric FACs analysis,gene microchips.

The Course is partly theoretical, partly practical, where lectures and laboratory work are integrated, half of the timeArbetsformer : will be given to the lecturing and half to the student work. The students will have the possibility to present their ongoing researchproject and to discuss their results eventually relayted to the Course topic. The study work will be organized each day with 8 hoursper day of frontal lecturing, 4 hours student course study and 4 hours students presentation. Using the course lectures and studentongoing research activity the student will be asked to shape his/her project work as a grant application. In particular The participantwill receive an introduction on the following laboratory techniques: Facs analysis using multiparametric technique Intracytoplasmstaining and lymphocytes subset definitions, Selection of appropriate fluorochrome to evaluate the different lymphocytes populations Collection and Handling of patient¿s blood samples Correct use of gene microchips arrays.

The course participants must pass an oral examination. In particular: It will be asked to present a research projectExamination : aiming to develop new therapy strategy in tumor and autoimmune disease. The examination will be based on: 1) The student mustcritically discuss and describe the principal immune tolerance mechanisms at cellular and molecular levels of the disease of a givendisease.This disease it is the subject for the research project presentation. 2) The students must extrapolate the possible tolerogenicmechanism/s involved in the disease and they should be able to describe the therapy intervention to break them in the case ofneoplastic disease or how to restore them in the case of autoimmune disease. 3) It is crucial that the student use in its applicationthe information got during the lecture. To pass the exam the application must aim to address relevant question in the course fields.The proposed project should be feasible, the student should choose the appropriate animal models, the experimental design shouldinclude the description of ex vivo, translational part ex vivo (experimental design, patients and control individual cohort recruitment). 4) To pass the candidate must be able in 15 minute with power point presentation present a project that must contain relevantinformation on the background of autoimmune and tumor tolerogenic mechanism, the in vivo and ex vivo experimental design mustbe appropriate. Course faculty will asses that the student acquired knowledge by questioning him and discussing with him theproject

All theoretical and pratical sessions are compulsory. Absence will be compensated (for a maximum of 2Obligatoriska moment : days) providing him/her with the missed lectures power point and related literature, in case that the absence is related to laboratorywork, an oral synthesis of the work done in the lab will provided by the instructor, the student will have the opportunity to visit the laband get a theoretical information on the scientific apparatus used.

8 - 20Antal studenter : The students selection wil be made by their curriculum, they must have been undertaken courses in genetic,Urval av studenter :

biology, biochemistry, histology,physiology. The course will held during one whole week 12-16 March 2012. The Course will be located at departmentYtterligare information :

of Microbiology Cell and Tumorbiology, Nobelvagen 16 Solna campus. The Course will overview the most recent acquisition in thefield of the immuno regulation with special emphasis on the tolerogenic mechanisms. The potential clinical use of this knowledge willbe discussed as well. The topic covered will be cell biology, genetic, immunology, internal medicine and tumorbiology. Learning howthe immune tolerance positive and negative modulation are general mechanisms behind the tumor progression or autoimmunedisease. Key concept of the experimental technique will be introduced as multiparametric FACs analysis, gene microchips. Thefaculty is composed by leading international scientist among them: Veronika Groh, Thomas Spies, Angela Santoni, FedericaCavallo, Klas Karre.

Kursansvarig : Ennio CarboneInstitutionen för mikrobiologi, tumör- och cellbiologi

[email protected]

ostgotagatan 66

116 64 Stockholm

Kontaktpersoner : -

Title : Communication - retorics, dialogue, memory technique and groupdynamics




Särskild behörighet : After passing the course, the PhD student should have: - tools for memory technique - practiced and learntKursens lärandemål :

about presentation skills and tools for presentations - gained more awareness about how to handle different communicationsituations - feel more secure and confident in dialogue and speech situations and be able to execute this knowledge - be skilled inhow to build rapport, strengthen the personal confindence and create good relations in order to improve the possibilities of sharinginformation and experiences - knowledge on argumentation and how to structure argumentation - knowledge on how to outline aspeech - practical applications of dialogue - knowledge on the rhetorical listening techniques - knowledge on how to useargumentation in order to exchange information, knowledge and experience - knowledge and understanding on group dynamics andcooperation - ganined a deeper understanding on the mechanisms behind cooperation; what breaks down cooperation, what buidscooperation betwwen individuals in a group? - gained understanding about why cooperation is difficult, in what ways humans areunique in their whay of cooperation - learnt about how to apply the mechanisms of cooperation in a research group

This course can be taken separately without any previous knowledge. The course can also be seen as a kind ofKursens innehåll : continuation of the phd course "Social skills and presentation technique" - if you have attended the previous course possibly you canget credit for some of the theoretical parts of the groups dynamics part of the course. Rhetoric- and dialogue: The participants willgain more understanding about the conditions for communication situations, for instancelike presentations, speeches, talks anddialogue based on rhetorical theories. There will be shorter therory lessions combined with practice in group and individually. Thecourse will emphasize on practical applications of the matters given as learning goals. Personal feedback will be given on allpractical sessions. Course content: - Rhetorical perspectives on trust and credibility - Argumentation and structure of argumentation - Disposition - Memory technique - Technique of presentation and handling of technical tools - Prerequisitions for dialogue -Dialogue, speech and discussion - similarities and differences - Argumentation as exchange of knowledge and experience - Thenature, tools and possibilities of dialogue - Listening in theory and practice - Questioning technique - Practical implications ofdialogue Group dynamics: After a theory part on the mechanisms and dynamics behind cooperation and how cooperation affectsyou as a member of a research group, we focuse on analyzing different cooperation problems. We try to understand howcooperation problems and difficulties raise, what mechanisms are activated and what can be done to improve the situation. Thecourse participants will ge given the opportunity to analyze their own relevant problems, as well as standard scenarios given by thelecturer. By understanding and applying the mechanisms which influence our inclination to cooperate we will be more successful inour relations to other people, no matter in personal or business relations

Group assignments, lectures and individual practice.Arbetsformer : Active participation in group work and individual assignments according to the learning goals. The lecturer will check,Examination :

according to a list with all learning goals, that the student reaches enough knowledge and understanding in the different parts of thecourse.

Active participation in group work, workshops and seminars. Absence can be compensated by writtenObligatoriska moment : assignment or by participating in next terms course.

5 - 10Antal studenter : a) motivation b) date for planned dissertation c) date for (planned) half timeUrval av studenter :

Welcome to apply for the course in communication! Lecturers will be Hans Bourghardt who is a seniorYtterligare information : consultant, lecturing on retorics and Helen Lindahl, dramapedagog and consultant in the field of presentation techniques andretorics. The course lectures will be at Karolinska Sjukhuset i Solna. Please address all questions to: Anna HildenbrandWachtmeister, [email protected] cell phone: 070-7890607



Title : Biology of Inflammation



ForskarnivåNivå : Department of Medical Biochemistry and BiophysicsKursansvarig institution :

Särskild behörighet : Following successful completion of the course, the student will acquire a basic level of knowledge in theKursens lärandemål :

biology of inflammation and its role in inflammatory-related disease processes. In addition, students will be updated on recentfindings within these fields. Specifically, students will be able to: Reflect on the utility of inflammation-related research in terms ofhypothesis generation and experimental design. Relate to principle the appropriate applications of different experimental approachesand theory to questions of disease etiology. Theorize on the future development of inflammation-related research approaches andits role in observed pathologies, as well as motivate the answer.

This course will be focused on the following research areas: 1) To determine why chronic inflammationKursens innehåll : sometimes, but not always, results in increased atherosclerosis and leads to myocardial infarction or stroke (cardiovasculardisease). 2) To identify novel therapy targets and investigate the effects of targeted therapies against chronic inflammatory diseasesand cardiovascualr diseases Taken together, these two approaches will allow us to both understand the etiology and pathogenesisof chronic inflammatory diseases and cardiovascular disease and provide a basis for improved prevention and therapy for chronicinflammatory diseases and inflammatory cardiovascular disease, two major challenges to health in the population. The developmentof cardiovascular disease (CVD) is dependent both on metabolic and inflammatory events and it is the most common cause ofpremature death in many chronic inflammatory diseases (CID). In spite of this, our understanding of the chronic inflammatorymechanisms that contribute to CVD is limited. CERIC will address this problem in a novel way, utilizing resources and opportunitiesalready at hand in experimental and clinical research to form a world-leading research environment, where it will be possible to studythe molecular pathogenesis of CID and CVD in well-defined clinical materials and animal models. The course will cover a number ofdiverse topics through its seminar series that includes key areas involved in the pathology of inflammation. Atherosclerosis is aninflammatory disease that is associated with systemic immune responses and signs of inflammation. Its lesions are filled withimmune cells that can orchestrate and effect inflammatory responses. In fact, the first lesions of atherosclerosis consist ofmacrophages and T cells. Unstable plaques are particularly rich in activated immune cells, suggesting that they may initiate plaqueactivation. Experiments in gene-targeted mice have provided mechanistic evidence that immune mechanisms are involved inatherosclerosis. During recent years, we have seen a rapid increase in understanding of the mechanisms that govern therecruitment, differentiation and activation of immune cells in atherosclerosis. Experimental research has identified several candidateantigens and there is encouraging data suggesting that immune modulation as well as immunization can reduce the progression ofthe disease. This course will specifically address these areas: chronic inflammation and atherosclerosis mechanistic studies inexperimental models inflammatory signalling in atherosclerosis and chronic inflammation ¿ exploration of the transcriptome andproteome in human disease immune activation and autoimmune cross-reactions in chronic inflammatory disorders shared effectormolecules in the molecular pathogenesis of chronic inflammatory diseases The role of B lymphocytes in chronic inflammatorydiseases will be addressed with the aim of understanding pathogenic processes and identifying targets for therapeutic intervention.We will focus on Sjögren's syndrome and congenital heart block using basic molecular studies, analysis in experimental models andclinical investigations. This course will specifically address these areas: dissect genetic contribution to the autoimmune associatedcongential heart block delineate the role of TRIM21/Ro52 in regulation of interferon responses and development of chronicautoimmune disease Recent evidence suggests that a previously unnoticed cytomegalovirus (CMV) infection can be detected intissue specimens from patients with many inflammatory diseases such as cardiovascular diseases, autoimmune diseases as well ascertain cancers. CMV infects and is carried by 70-100% of the world¿s population. For many years, CMV was not considered to be amajor human pathogen, since the virus only caused rare cases of CMV inclusion disease in neonates. CMV is an importantpathogen in immunosuppressed patients such as transplant patients and AIDS patients. CMV disease in these groups of patientshas also high-lightened the role of the virus in the development of other inflammatory diseases. This course will specifically addressthese areas: To further understand how CMV is involved in the development of inflammatory diseases. To further understand therole of CMV as a link between rheumatic diseases and cardiovascular diseases. Arachidonic acid is the precursor of a broadspectrum of bioactive lipids in plants and animals. In mammals, the most well known classes are the prostaglandins, thromboxanes,leukotrienes and lipoxins which all have powerful and diverse biological activities related to a multitude of physiological as well aspathological conditions. We will focus on a family of lipid mediators called the leukotrienes (LT) involved in a number of inflammatoryand allergic diseases, in particular asthma, rheumatoid arthritis, and arteriosclerosis. Based on research on metabolites andproteins in the arachidonic cascade, a number of new drugs against inflammation, allergy, asthma and glaucoma have beendeveloped and new pharmacological principles continuously evolve from this research area. This course will specifically addressthese areas: Studies on the role of eicosanoids in atherosclerosis and CVD Elucidation of lipid and peptide mediator synergies in theinnate immune response Impact of CMV infection on cellular eicosanoid synthesis and actions Effects of anti-inflammatory,anti-rheumatic drugs on the eicosanoid cascade Antimicrobial peptides are effector molecules in innate immunity and can beconsidered endogenous antibiotics. The peptides are present in several blood cells with the highest concentration in neutrophils, thefirst cells recruited to a site of infection. The peptides represent key defense-components at epithelial surfaces, the barrier betweenthe external environment and the interior milieu in humans. It has been found that some pathogens are able to turn off theexpression of the endogenous antimicrobial peptides, resulting in serious infections. Interestingly, the short-chain fatty acid butyratecan counteract down-regulation as shown in experimental shigellosis. This course will specifically address this area: The role ofantimicrobial peptides and more specific LL-37 in chronic inflammatory diseases. There are a range of factors involved incardiovascular disease and it is important to identify and functionally characterise novel genes, genetic variants and pathways thatconfer susceptibility to coronary artery disease (CAD) and aneurysm formation. The tools to attain these goals comprise a

combination of large-scale genome-wide association studies (GWAS), quantitative trait locus (QTL) mapping in humans and rodentmodels and gene expression profiling in rodent and human target tissues for the gene discovery phase, whereas the functionalcharacterisation of candidate genes is performed in vitro as well as in vivo in model systems and in carefully phenotyped humansubjects. This course will specifically address these areas: To identify and functionally characterize susceptibility genes forcardiovascular disease, with particular emphasis placed on defining which allelic variants in immunoregulatory genes affect risk. Toclarify which immunoregulatory pathways control atherosclerosis, plaque instability and clinical events such as myocardial infarction.To establish an animal model of both rheumatoid arthritis (RA) and atherosclerosis and to explore genes known to affect arthritisand/or atherosclerosis in the arthritis/atherosclerosis model. To identify common mechanisms for chronic inflammatory disorders bycomparing genome wide scans of human cohorts suffering from either CAD, RA or multiple sclerosis. In order to obtain basicbiological knowledge explaining the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosisexperimental animal models are often used. The ultimate goal is then to identify prognostic markers and to establish new therapiesfor these diseases. This course will specifically address these areas: to develop an animal models and genetic platform for studies ofpathogenic mechaisms in chronic inflammatory diseases to investigate in depth the genetic contorl of oxiudation pathwayscontrolling autoimmunity and inflammation to validate new preventive and therapeutic possibilities for the future prevention andtreatrment of chronic inflammatory diseases Psoriasis is a common, hereditary and clinically highly heterogenous disease where thegenetic background in combination with environmental triggers determine disease phenotype, severity and likely response totreatment. The ultimate cause for psoriasis is still unknown. Using a Stockholm cohort of individuals diagnosed within maximum 12months of disease onset, we study disease triggers, phenotype/genotype correlation, clinical course, comorbidities and response totreatment. Healthy individuals matched for sex and age serve as control. Even though skin is the main target organ, psoriasis istoday considered as a systemic disease with significant co-morbidities such as arthritis and cardiovascular disease. Our cohort withcarefully phenotyped patients coupled with an extensive biobank provide serves as our main research tool. Another line of researchis the role for the human antimicrobial cathelicidin peptide LL-37 in chronic inflammation and as a driver for autoimmunity.. Thiscourse will specifically address these areas: Immunobiology of chronic inflammation Psoriasis , the metabolic syndrome andcardiovascular co-morbidity Common genes between psoriasis, MS and atherosclerosis ? The role of LL-37 in chronic inflammationand autoimmunity Since MS is caused by inflammation, which can be controlled, the disease should in principle be curable or atleast to be possible to prevent to a large extent. Some of the currently available therapies, and those emerging, are in fact able todampen the relapse rates up to 70 %. However, they broadly interfere with the immune system, which is needed in the defenceagainst infections, and may be risky at a long term perspective. Therefore, the primary goal in a long term perspective is to achievea more detailed knowledge on the exact modes and mechanisms in which the immune system is allowed to attack the nervoussystem in order to develop much more precise therapeutic interventions. In addition to the immune system, target-related factorsmay be important, both regarding local expression of molecules interacting with the immune system and factors relating to thesusceptibility of the CNS to inflammatory damage. Both environmental factors and gene variants contribute to the cause of MS. Thegenes involved are likely to be many, probably in the order of a hundred and therefore may differ between different individuals withMS. Nevertheless, exact knowledge of these risk genes may disclose critically regulated bottlenecks in disease pathogenesis. As forother autoimmune diseases this has been a working hypothesis for decades, but it is not until now, with recent technological andintellectual developments, that this can be properly studied. Classical hypothesis driven research focuses on single molecules. Itcarries the risk that years of work are spent on a mechanism of no relevance for disease. An alternative approach, which we havesuccessfully used since many years, is to identify natural gene variants affecting disease course and susceptibility in rat models topin point those molecular pathways which are central in disease pathogenesis. Once identified, these can then be dissected withclassical techniques. In addition, association of human orthologues with disease can be studied in large case-control materials. Thiscourse will specifically address these areas: Fine dissection of polymorphic genes regulating rat models of MS and inflammatoryneurodegeneration after nerve trauma using advanced intercross lines (AIL), a heterogeneous stock (HS) and recombinant congenicmapping under the assumption that interspecies conserved mechanism may be of relevance for human neuroinflammatory disease.By comparative genetics, study if the same gene, or genes in the same pathway, are of relevance in human disease. Functionallydissect these pathways in rodents, and also study potential therapeutic intervention. Study potential gene-environment interactionsin a large ongoing case-control study.

Research seminars and a written assignment.Arbetsformer : Satisfactory completion of the course will be assessed by written examination consisting of a research report on anExamination :

aspect of inflammation biology. The learning outcomes of the course have to be taken into account in this report. The exact subjectof the report may be chosen by the student, but must be approved by the course organizer. The final report must be 3 A4 pages orless (12 point font, 2.54 cm margins) including references and must be turned in within 2 weeks of course completion in order toreceive course credit (there is no minimum length). The report should make use of the journal articles and concepts discussedduring the course, which are expected to generate ideas for the reports. In the event of an unsatisfactory report, as determined bythe course organizer, the student will be given one additional week to re-write and resubmit the report.

Attendance at the seminars is required. In the case of necessary absence, the student will be required toObligatoriska moment : read an appropriate journal article on the missed material and then demonstrate sufficient understanding in a 5 minute oral interview.

5 - 50Antal studenter : All students with interest in the course material will be accepted.Urval av studenter :

As in past offerings, this course will be on Fridays from 15:00-16:00 throughout the spring academic term.Ytterligare information : The scheduled dates are: January 13th, January 20th, January 27th, February 3rd, February 10th, February 17th, February 24th,March 2nd, March 9th, March 16th, March 23rd, March 30th, April 13th, April 20th, April 27th, May 4th, May 11th, May 25th, June1st, June 8th

Kursansvarig : Craig WheelockInstitutionen för medicinsk biokemi och [email protected]

Kontaktpersoner : -

Title : Aktuell Omvårdnadsvetenskap - teori och praxis




Tidigare studier inom vårdområdet och närliggande områden i förhållande till forskningsprojektets inriktning.Särskild behörighet : Kursen syftar till fördjupning i omvårdnadsämnets begreppsliga och teoretiska grunder, samt granskning ochKursens lärandemål :

värdering av aktuell omvårdnadsvetenskaplig forskning. Mål för lärande är studerandes tillägnan av omvårdnadsvetenskapligbegrepps-och teorigrund samt pågående omvårdnadsvetenskapliga paradigm och diskurser. Studerande ska kunna ställa sammanvetenskapteroretiska grunder för teori och begreppsutveckling inom omvårdnad samt kunna tillämpa detta i relation till egenforskningsinriktning. Studerande ska kunna förklara den historiska utvecklingen av omvårdnad som vetenskap och kunnasammanfatta för innehållet i utvalda omvårdnadsteorier Studerande ska kunna kritiskt granska, analysera och värdera utvecklingenav omvårdnadsvetenskapliga begrepp relaterat till egen forskningsinriktning.

Vetenskapsteoretiska aspekter på omvårdnadsvetenskap Teoriutveckling och begreppsutveckling inom enKursens innehåll : vetenskap Omvårdnadsvetenskapens historia och utveckling fram till idag Granskning och värdering av aktuellomvårdnadsforskning samt pågående teoriutveckling

Målen bearbetas genom att studera andra universitet i Nordens utveckling och forskningsprogram inom omvårdnad-Arbetsformer : vårdvetenskap. På olika sätt bekantar vi oss med, analyserar och granskar kritiskt, paradigmutvecklingen inom ämnet idag. Kursenbygger på en huvuddel av självstudier av litteratur. Arbetsformerna på campus är seminarier samt föreläsningar.

Litteraturuppgifter på obligatorisk kurslitteratur samt integrativ granskning och analys av omvårdnadsteoretiskaExamination : grundbegrepp i relation till eget projekt.

Undervisningsmomenten på campus, föreläsningar och seminarier under kursen är obligatoriska. FrånvaroObligatoriska moment : kompenseras genom genom skriftliga eller muntliga extrauppgifter vilka beslutas av examinator.

12 - 30Antal studenter : Om urval måste ske, görs en bedömning utifrån kursens förmodade nytta för eget forskningsprojekt. AnsökanUrval av studenter :

ska därför innehålla en motivering för kursdeltagande. Kursen ges på halvfart med studier på campus Huddinge en torsdag samt 6 fredagar. VälkändaYtterligare information :

föreläsare, professorer inom omvårdnad- vårdvetenskap inleder kursdagarna. VT 2011 deltog KI:s Ann Langius, PO Sandman,Sirkka-Liisa Ekman, Kim Lutzén och Arne Rehnsfeldt. Inbjudna föreläsare har varit många genom åren; Katie Eriksson kommervarje år, Astrid Norberg, Ingegerd Bergbom, Carina Berterö, Berit Lundman har deltagit för att nämna några. Seminarier ochteoridialoger följer som fördjupning.

Kursansvarig : Maria Arman Institutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Kontaktpersoner : -

Title : Gene Expression Analysis




Särskild behörighet : Following successful completion of the course.. The student will be able to account for the main currentKursens lärandemål :

methods for analysis of gene expression data and and their advantages and disadvantages including what questions can beaddressed with each different method. The student will know the important tools, databases and resources for gene expressionanalysis available to the researcher on the internet. The student will know how to find the main commercial tools used in academiaand industry. The student will have hands on experience in every step of the process starting from preprocessed expression data topublication figure, with their own research data if available or with the data provided by the tutors. The student will have an overviewof the direction of the research field, both of new methods of measuring gene expression data, and of analysis methods.

Concepts that are discussed during lectures and literature seminar include: Analysis methods such as: t-test,Kursens innehåll : ANOVA, false discovery rate (FDR), principal component analysis (PCA), Genetic Networks, gene ontology (GO), gene setenrichment analysis (GSEA), cluster analysis Freely available resources and tools such as Kyoto Encyclopedia of Genes andGenomes (KEGG), SPRING, Gene Expression Omnibus (GEO), Bioconductor R. The future of gene expression analysis. Thecourse is practical, and focuses on different Work-Flows for analyzing gene expression data.

The course consists of lectures, literature seminar, teacher assisted computer exercises and home assignment.Arbetsformer : The examination will be in the form of A computer laboratory exercise and home assignment. Literature seminarExamination :

presentation concerning analysis methods or data collection methods. Completed gene expression analysis using one of the workflows presented in the course that fits the data set and question at hand. Furthermore the way the students are able to discuss theissues in connection with the lectures will form part of the examination.

Attendance at laboratory sessions is required. In the case of absence, the student will be required to doObligatoriska moment : the laboratory exercises at home.

8 - 20Antal studenter : Selection based on relevance of the course to the students doctoral project.Urval av studenter :

The course is given in KI campus Huddinge. Preliminary schedule: Lectures: Mon, Tue. Computer lab:Ytterligare information : Mon, Tue, Wed. Group work: Thu. Seminar: Friday

Kursansvarig : Andreas MonteliusInstitutionen för [email protected]

Karolinska University Hospital

14186Stockholm

Kontaktpersoner : Andreas MonteliusInstitutionen för [email protected]

Karolinska University Hospital

14186Stockholm

Title : Communicate your research! - A crash course in science communication




Särskild behörighet : At the end of the course the students are expected to be able to: Apply the basics in communication theoryKursens lärandemål :

and be able to reflect on why it is important to communicate science, understand how media works and the role of journalists, Writea short popular scientific text, give an short oral presentation about own research adapted to a non-scientific target group and reflecton presentation skills and ability to adapt to different target groups.

The course contains theoretical and practical sessions on communication theory, popular science writing andKursens innehåll : presentation skills. There will also be an introduction to media and how to give an interview. This is a practical session where thecourse participant will be interviewed by a journalist or a journalist student; a unique opportunity to experience a real life interviewsituation.

The course is 1 week full-time with scheduled lessons and practical training for 3 days. To increase the learningArbetsformer : process the students will write and send in forehand a short text in a popular scientific context. During the course the student willhave time to rewrite the text supported by feedback and course leaders input.

The examination of the course consists of fulfilling the compulsory session. Compulsory sessions are: 1. OralExamination : presentation in a popular science context. 2. Writing a short text in a popular scientific context. 3. Give feedback to a written popularscience text made by a peer. To pass the course the participant needs to show evidence that they reached the learning outcomes byfulfilment of the assessment criteria.

Students are expected to attend all lectures and presentations and provide a written assignment. In theObligatoriska moment : case of absence, the student will be asked to compensate through supplementary activity such as another writing assignment basedon a scientific paper given by the course organizers

10 - 15Antal studenter : According to date of admission as doctoral student at KI.Urval av studenter :

The course is one week full-time with scheduled lessons and practical training for three days (MarchYtterligare information : 26-28, 2012). To increase the learning process the students will write and send in a short popular science text before the coursestarts. The course is at Campus Huddinge.

Kursansvarig : Johanna ZilliacusInstitutionen för biovetenskaper och näringslä[email protected]

Kontaktpersoner : -

Title : Causal Inference for Epidemiological Research




The students are expected to have taken Epidemiology I, Epidemiology II, Biostatistics I, and Biostatistics II.Särskild behörighet : Exceptions can be made if the students have taken other courses with an equivalent content.

After the course the student will - be able to use counterfactuals to express and interpret causal queries - beKursens lärandemål : able to judge when standard statistical methodology is appropriate for causal inference, and when it is not - be able to use DirectedAcyclic Graphs to describe and analyze complex epidemiological scenarios - be able to use Marginal Structural Models to analyzelongitudinal data, with additional help from a skilled statistician

Causal inference from observational data is a key task of biostatistics and of allied sciences such as sociology,Kursens innehåll : education, behavioral sciences, demography, economics, health services research, etc. These disciplines share a methodologicalframework for causal inference that has been developed over the last decades. This course presents this unifying causal theory andshows how biostatistical concepts and methods can be understood within this general framework. The course emphasizesconceptualization but also introduces statistical models and methods for time-varying exposures. Specifically, this course strives toa) formally define causal concepts such as causal effect and confounding, b) identify the conditions required to estimate causaleffects, and c) use analytical methods that, under those conditions, provide estimates that can be endowed with a causalinterpretation. The (causal) methods can be used under less restrictive conditions than the traditional statistical methods. Forexample, causal methods allow one to estimate the causal effect of a time-varying exposure in the presence of time-dependentconfounders that lie on the causal pathway between exposure and outcome.

Lectures and group discussions.Arbetsformer : There will be a take-home exam handed out at the last day of the course. Students who fail will be given theExamination :

opportunity to write at a maximum 2 re-exams. Dates for the re-exams will be announced later.Obligatoriska moment :

12 - 25Antal studenter : Prerequisite knowledge is equivalent to the learning outcomes of Epi I(1577), Epi II(1622), Biostatistics IUrval av studenter :

(1579), and Biostatistics II(1513). Eligible PhD students will be prioritized according to 1) relevance of the course for their research,and 2) motivation for attending the course. To be considered, submit a completed application form. Give all information requestedincl. short description of current research project and motivation for attending and an account of previous taken courses.

The course is held 13, 15, 17, 20 and 22 February.Ytterligare information :

Kursansvarig : Yudi PawitanInstitutionen för medicinsk epidemiologi och biostatistik

[email protected]


Title : Principles of nucleic acid structure




Särskild behörighet : After the course, the participants will be able: - to describe and to visualize nucleic acid structures. - to applyKursens lärandemål :

principles regulating nucleic acid structures. - to explain the relation between structure and function in nucleic acid molecules - toevaluate critically experiments used to provide RNA or DNA structural information.

A general introduction to nucleic acids nomenclature. Structural and conformational features of nucleotides. Kursens innehåll : Physical properties. Hydrogen bonding and base stacking. Water and nucleic acid. Metal ion and nucleic acid. Secondary andtertiary structures of DNA and RNA. Methods to determine structures and dynamics of DNA and RNA systems (such as x-raycrystallography, NMR, theoretical approaches and so on) General consideration on protein-nucleic acid interactions, DNAsuper-helix, higher order nucleic acid structure. Small introduction to secondary structure predictions, structural database, molecularvisualization. Three invited lectures on specific topic.

The course consist in lectures, seminars, short presentations given by the participants. group activities under theArbetsformer : supervision of the course leader, computer tutorials on database and molecular visualization (14 meetings of three hours each) During the course period, the participants will work individually on an written assessment portfolio, give and receive feedback on thewritten work. In addition, the participants will prepare and discuss a seminar on an assigned topic. The participants should integrateeach lectures hour with homework and reading.

A final written exam will be used to assess the participant's ability to describe and apply the structural principles ofExamination : nucleic acid structures. The seminar and written assessment portfolio will be used to assess the participant's ability to explain therelation between structure and function in nucleic acid molecules and to evaluate critically experiments used to provide RNA or DNAstructural information.

The participant must participate actively by attending the lectures and the seminars, by completing theObligatoriska moment : assigned tasks. In addition, the participant must complete the assessment portfolio and final exam. Absence to a lecture will becompensated with extra assignments. The students will get some key questions on the corresponding lecture, and the answersshould be submit in written form for review and approval.

8 - 20Antal studenter : Priority will be given to KI students working on projects that required knowledge in nucleic-acid structure.Urval av studenter :

Selection is based on the motivation given in the application form. The course is in the blue seminar room in the NOVUM building, (Huddinge). The meetings will be onYtterligare information :

Monday, Wedsnesday and Thurday morning from 9-12 (except Thur 2/2 from 13-16 and Wed 22-2 no meeting)

Kursansvarig : Alessandra VillaInstitutionen för biovetenskaper och näringslä[email protected]

Hälsovägen 7NOVUM141 83Huddingen

Kontaktpersoner : -

Title : Career skills for scientists




Särskild behörighet : After the course the participants should be able to discuss options in academic and nonacademic careers.Kursens lärandemål :

The participants should be able to identify transferable skills achieved during doctoral training and be able to explain the value ofthese skills within as well as outside academia. They will also be able to describe the financing procedure of research projects,discuss project management and be able to apply what they have learned in the course to market their skills in different situations.

The course includes an introductory reflection of what career options that are available for the participant. ThisKursens innehåll : will be followed by sessions where academic and non-academic careers paths and entrepreneurial options are presented anddiscussed. The course covers financing of research activities, project management and different career paths. In addition, the courseincludes the process and steps in a job application procedure and how to use communication skills in various contexts.

The course will be highly interactive and will consist of lectures, discussions, individual projects and studentArbetsformer : presentations.

The participants will be examined with a small written individual project and group presentations.Examination : It is compulsory to attend all the lectures and workshops (except where clearly stated otherwise). AbsenceObligatoriska moment :

from compulsory parts will be compensated for according to instructions of the course director with an additional individual project.20 - 35Antal studenter :

The selection is based on the personal motivation letter on why to take the course. Preference will be given toUrval av studenter : students that 1) have completed half time control and 2) whishes to attend the PhD student internship program (Read more underdetailed information) and have written consent from the supervisor for taking the external internship.

The course is organized jointly by KI Career Service (KICS) and the Unit for Bioentrepreneurship (UBE).Ytterligare information : The course leaders are Kerstin Beckenius, Anethe Mansen and Michaela Prochazka (KICS). The course faculty consists of lecturersfrom the KICS network and from UBE. The course is part time (daytime), preliminary 1 day/week. More course information can befound at www.ki.se/careerservice and directly from the course leaders. This course is also given as a part of an Internship programfor doctoral students (registered at KI). The program consists of this course as well as an option to apply for a one month internshipin an organization within the private sector, public sector or the nonprofit sector. It aims at enhancing contacts betweenorganizations outside academia and KI researchers and to prepare PhD students for careers after obtaining their doctoral degree.

Kursansvarig : Madelen LekInstitutionen för lärande, informatik, management och etik

[email protected]

Kontaktpersoner : Kerstin BeckeniusUniversitetsförvaltningen

[email protected]

Anethe MansenUniversitetsförvaltningen

[email protected]

Michaela ProchazkaUniversitetsförvaltningen

[email protected]

Title : Calcium signaling



ForskarnivåNivå : Department of Clinical Science and Education, SödersjukhusetKursansvarig institution :

Särskild behörighet : At the end of the course the participants will understand the fundamental molecular proceses involved inKursens lärandemål :

maintaining intracellular Ca2+ homeostasis and their roles in the generation and decoding of Ca2+- and phospholipids-mediatedsignals. They will be able to analyse and interpret the existing literatures critically, and address new question in this area ofresearch. They will understand the principles of common methods including those of microscope based fluorometry in living cells,confocal and multiphoton imaging and electrophysiology. Participants will see actual demonstration of the methods used formeasurement of intracellular free Ca2+ concentration by microfluorometry and confocal microscopy. After completion of the course,participants will be able to come up with new ideas, generate new hypotheses and identify approaches to test them by using diversemethods and approaches.

1. Phospholipase C and inositol 1,4,5 trisphosphate-mediated signaling. 2. Identity and roles of molecularKursens innehåll : players involved in Ca2+ and phospholipid mediated signaling. 3. Preparation of Ca2+ buffers. 4. Methods used in the study ofcalcium and phospholipid signaling including fluorescent techniques, electrphysiology and imaging techniques. 5. regulation of ionchannels involved in Ca2+ signaling including voltage sensitive channels, transient receptor potential channels, store-operatedchannels and intracellular Ca2+ channels. 6. roles of Ca2+ and phospholipid mediated signaling in cellular processes including insecretion and apoptosis. 7. Mechanism of generation and decoding of Ca2+ signals. 8. spatial and temporal aspects of Ca2+signaling. 9. How to pick research problems in the areas of Ca2+ and phospholipid signaling and how to approach them.

This course will follow the classical seven steps approach of problem-based-learning (PBL). Emphasis will be onArbetsformer : self-directed learning through problem-solving in small groups rather than on cathedral lectures. However, generous small groupinteractive lectures by resource personnel and selected practical sessions will be provided. Participants will work on five givenproblems, in groups of about nine participants, under supervision of two trained facilitators who will be available during all of thesessions. Participants will be provided with an outline of the objectives, areas expected to cover, and reprints of selected learningmaterials. In practical sessions, participants will observe the use of fura-2-based microfluorometry and confocal microscopy formeasurement of cytoplasmic free Ca2+ concentration.

1. Observation by the facilitators of the participants role in the learning processes during group activitites. 2.Examination : Presentation of assignment in group-seminar. 3. Individual written reports.

Submission of a short written report is essential for obtaining a pass grade. The supervisors guides inObligatoriska moment : writing this report.

10 - 20Antal studenter : Selection will be based on: 1: Date of registration date 2. Motivation of attendingUrval av studenter :

The course starts at 09:00 and ends at 16:00 every day. The course will be given at the Department ofYtterligare information : Clinical Science and Education, Södersjukhuset.

Kursansvarig : Shahidul IslamInstitutionen för klinisk forskning och utbildning, Sö[email protected]

Kontaktpersoner : -

Title : PASW I (SPSS) - datahantering för att beskriva dina data




Grundläggande statistikkunskaperSärskild behörighet : Efter kursen skall doktoranden: - Ha grundläggande kunskaper om statistikprogrammet PASW (tidigareKursens lärandemål :

SPSS) för att skapa strukturerade datafiler, modifiera data, samt skapa grafer och tabeller med hjälp av programmets menysystem. - Självständigt kunna skapa en datafil utifrån ett protokoll/enkät och mata in data. - Självständigt kunna definiera, sortera, modiferaoch selektera data för enklare situationer. - Självständigt kunna skapa grafer och avancerade tabeller och göra enklare redigeringar. - Ha en grundläggande insikt om olika typer av fel som kan uppstå vid datahantering.

Syftet med kursen är att stödja doktoranden att snabbt komma igång med statistikprogrammet PASW. KursenKursens innehåll : vänder sig främst till kliniker och andra doktorander som planerar att använda PASW för datahantering och analys underforskarutbildningen och vill få en överblick över programmet och dess möjligheter på ett strukturerat sätt. Kursen fokuserar pådatahantering och att beskriva ett datamaterial. Statistiska tester för att jämföra grupper och tidpunkter behandlas ej. Därav följandeinnehåll: -Grunderna i PASW: Dataeditor, ouput-, syntaxfönster -Skapa nya variabler och bestämma format: numerisk, string, datum -Mata in, förklara och förtydliga data -Att definiera bortfall -Rutiner för att kontrollera data -Beskrivande statistik och korstabeller -Skapa och redigera avancerade tabeller -Sortera, selektera och skapa delgrupper i ett datamaterial -Koda om data och skapavariabler från dina befintliga variabler -Introduktion till syntaxer för att dokumentera datahanteringen -Introduktion till att räkna meddatumvariabler -Skapa och redigera grafer -Slå ihop datafiler -Praktiska tips och trix för att spara tid och minska risken för fel

Datorövningar kombinerat med katedrala moment. Föreläsaren går igenom och demonstrerar de olika momentenArbetsformer : och därefter får du själv arbeta med övningsuppgifter under handledning. Varje doktorand får tillgång till dator med PASW.

Varje doktorand lämnar enskilt in lösningar till ett antal uppgifter baserade på datorövningarna under kursen. Tid förExamination : att lösa dessa uppgifter avsätts under kursen med möjlighet till löpande feedback från lärare.

Vid frånvaro från datorövningarna får doktoranden göra kompletterande övningsuppgift/-er. Obligatoriska moment : 17 - 21Antal studenter :

1. Registrerade doktorander. 2. Tidpunkt för doktorandregistrering - den som är registrerad först väljs först. Urval av studenter : Heldagar 9-16 på KI SÖS, Södersjukhuset. Kurslokal meddelas senare Ytterligare information :

Kursansvarig : hans PetterssonInstitutionen för klinisk forskning och utbildning, Sö[email protected]

Kontaktpersoner : -

Title : Methods and ethics in research with children




Särskild behörighet : At the end of the course the students should: - know and describe the concept of childhood and itsKursens lärandemål :

development and variation - know the main aspects of children's rights and understand how theu affect the involvement of children inresearch - be familiar with methods to enhance children's participation in research - know, understand and discuss ethicalconsiderations when involving children in research

- Concepts of childhood historically and interculturally - The convention on the rights of the child - Methods forKursens innehåll : children's participation in research - Informed consent from minors, ethical considerations when involving minors

Lectures, seminars and literatureArbetsformer : A written assignment given on the first day of the course and to be handed in within one week after the course.Examination :

Seminars are compulsory and any absence must be compensated for after discussion and agreement withObligatoriska moment : the course-leader.

15 - 20Antal studenter : Students will be selected giving priority to students whose research projects include research involvingUrval av studenter :

children actively in the research process children and adolescents and in accordance with date of applicationThe course is a fultime course (09.00 - 16.00) and seminars are compulsory. We will work in groups toYtterligare information :

discuss and practice how to involve children in the data-gathering and analysis.

Kursansvarig : Birgitta RubensonInstitutionen för folkhä[email protected]


[email protected]

Title : Manuscript writing




IngenSärskild behörighet : After the the course the students will be able to write scientific manuscripts in English for publication inKursens lärandemål :

journals, choose words, structure a sentence and use punctuations properly, write clearly and concisely, maximize information andminimize words, organize a manuscript in paragraphs, present data effectively, review iterature and write a discussion, summarizeeffectively, understand the guidelines of authorship and the process of choosing an appropriate journal and submission of amanuscript, and write a rebuttal letter to address the comments of the referees.

1. Basic aspects of sentence structure. Choice of words. Writing in the active voice 2. Basic skills of writing.Kursens innehåll : Punctuations. Tips for clarity and brevity 3. How to maximize information and minimize words. How to organize a manuscript 4. Howto present data and describe tables and figures effectively 5. How to review the literature and write an effective discussion 6.Guidelines for authorship; choice of journals and submission of manuscript 7. How to address the comments of the referees. Detailsare as follows: Day 1. Lecture 1. Introduction. Basic aspects of sentence structure. Choice of words. Writing in the active voice. Group activity One: Editing exercise: revise sentences and change words for clarity and brevity Read a selected chapter ofSuccessful Scientific Writing Day 2. Lecture 2. How to maximize information and minimize words. Group activity Two: Choose alengthy article (2000+ words) from any magazine. Rewrite it about 500 words. Read a selected chapter of Successful ScientificWriting Day 3. Lecture 3. Basic skills of writing. Punctuations. Tips for clarity and brevity. Group activity Three: Write an introductionof your current focus of research. Peer review of the writings. Home work: Read a specified chapter from Successful ScientificWriting Conference 1. Discussion on writing exercises Day 4 Lecture 4: How to present data and describe tables and figureseffectively Group activity Four: Discuss specified journal articles that describe data in different ways. Home work: Prepare methodsand result section of your ongoing manuscript. Read a specified chapter from Successful Scientific Writing. Day 5 Lecture 5: How toreview the literature and write an effective discussion. Group activity Five: Write a short review on any topic in your area ofresearch. Examination:

1. Lectures will be in small groups and interactive 2. In group activity, students will work in small groups (3-5) onArbetsformer : given assignments 3. Home work will include reading specified chapters from specified books 4. Classroom exercises will includewriting of short reports and peer review 5. Conferences will include editing of writing and discussion on how to rewrite 6. Studentswill submit a written manuscript/report in English Supervisor will facilitate group activities, discussions and the overall learningprocess

Students will be given an assignment to write a text in English (about 1000 words). Examination : All participants will have to submit a written report/manuscript by the end of the course Obligatoriska moment :

10 - 20Antal studenter : We shall select first of all the doctoral students registered at the Karolinska Institutet. We shall select theUrval av studenter :

participants 1. based on their date of registration as doctoral student 2. based on the motivation to participate in the course. The course starts at 09:00, and ends at 16:00 every day. The course will be given at the Department ofYtterligare information :

Clinical Science and Education, Södersjukhuset.

Kursansvarig : Shahidul IslamInstitutionen för klinisk forskning och utbildning, Sö[email protected]

Kontaktpersoner : -

Title : Analysis of cancer with the next generation of high through puttechnologies




Särskild behörighet : After the course the students will be able to: Explain and discuss different areas of next generationKursens lärandemål :

HTP-methods in genomics, transcriptomics, proteomics, imaging in research of cancer. Describe the use of bioinformatics linked tothese tools. Know of the facilities of the joint laboratory between KI, KTH and SU - the Science for Life-laboratory.

The current use of modern methods for analysis and detection of cancer will be introduced by experts in theKursens innehåll : specific field. The course will include interactive assignments between lecturers and the PhD students. Specific areas: mapping thehuman proteome, sequencing the human genome, imaging of disease, finding disease biomarkers and bioinformatics of disease.The course will be held at the Science for Life-laboratory.

2-4 lecturers per day to cover the subject, with a possibility for the students to have a small interactive workshopArbetsformer : with the lecturer after each lecture ('Meet the scientist').

Fulfillment of interactive assignments. Examination : All parts are mandatory, as this information cannot be obtained thorugh the litterature. Absence will beObligatoriska moment :

compensated by separately organized discussion and assignment with the respective teacher.12 - 20Antal studenter :

The selection criteria are 1) the usefulness of the course for the doctoral student in his/her research project,Urval av studenter : and 2) the motivation given in the application to the course.

Full time every day, 9.00 - 17.00. Lectures, group discussions and demonstrations of techniques. EachYtterligare information : day will focus on one technology: the human proteome, human genome sequencing, imaging,disease biomarkers andbioinformatics. Lectures by Emma Lundberg, Joakim Lundeberg, Hjalmar Brismar, Jochen Schwenk and Thomas Svensson. Thecourse will be held at the new Science for Life-laboratory, next to KI campus.



17177Stockholm

Kontaktpersoner : -

Title : Basics of Qualitative research




Särskild behörighet : At the end of the course the participants will be able: 1. To describe experience of a classroom climate thatKursens lärandemål :

incorporates principles of respect, mutuality, cooperation, collaboration, and teamwork. 2. To apply knowledge of qualitativeresearch methods for discussing rationales for the design of the qualitative inquiry 3. To critically compare of qualitative andquantitative research (basic assumptions of the qualitative research paradigm as it compares to the quantitative paradigm) 4. Todescribe the common essential elements of qualitative research including How to select the appropriate: qualitative researchmethods based on phenomenon of interest setting for data collection study participants data generation strategies (includingindividual interviews, focus group discussion, written narratives, participants observation and field notes) and data analysis method5. To critically comments on/evaluate the weaknesses and strengths of the studies(published papers) using qualitative research interms of research question, aim and method 6. To design a qualitative research proposal in field of health

The course will provide some of the most important information which students need to understand andKursens innehåll : implement successful qualitative research methods (including the common essential elements of qualitative research). In additionthe course will provide step by step guidance to examine and apply current qualitative methodologies as a way to generate,manage, analysis qualitative data and moreover ,ethical considerations. The course will starts with the definition of qualitativeresearch, basic assumptions and characteristics of qualitative research in comparison to quantitative research. Following that will bethe notion of some common essential elements in qualitative methods such as: selecting the methods based on phenomenon ofinterest, using the literature review, choosing the setting for data collection, selecting participants, generating data and contentanalysis .After that , practical principle to do qualitative inquiry will be addressed. Finally ethical considerations in qualitativeresearch will be explained.

The learning activities on the course are a mix of lectures, discussions, individual and group; interview, seminar,Arbetsformer : field observation and individual presentations.

The course assessment will include formative and summative assessments. The formative assessment (50%) will beExamination : made through Peer learning Activity, critic a qualitative paper, individual and group presentation, while summative assessment(50%) will be through a written examination and individual qualitative proposal. In this way, the students are examined with bothgroup-wise and individual presentations.

Active participation in the class discussions, individual and group assignment (individual and groupObligatoriska moment : interview and field observation), written assignment (an abstract of a qualitative proposal) and student presentations is mandatory.Compensation according to the instructions of the course director, which means absentees less than 2 lectures is acceptable andshould be compensate by individual project related to absentee¿s session.

10 - 30Antal studenter : The primary selection criteria are 1) the usefulness of the course for the doctoral student in his/her researchUrval av studenter :

project, and 2) the motivation given in the application to the course.The course will be held at the Department of Clinical Science and Education, Södersjukhuset. This courseYtterligare information :

is intended to provide students with basic knowledge of qualitative research. It is help participants develop an understanding,knowledge, skills and comfort with qualitative research methods, as an additional alternative in health related research. Thequalitative paradigm will be presented as complimentary to quantitative methods rather than contradictory and competitive. Thelearning activities on the course are a mix of lectures, discussions, individual and group; interview, seminars, filed observation andindividual presentations. Invited Teachers: Professor Eva Johansson; Grounded theorist Professor Sirka Lisa Ekman ;Phenomenologist.

Kursansvarig : Hamid KhankehInstitutionen för klinisk forskning och utbildning, Södersjukhuset

[email protected]

Sjukhusbacken 10118 83

Stockholm

Kontaktpersoner : Jeanette Brynholt OhrmanInstitutionen för klinisk forskning och utbildning, Sö[email protected]

Title : Research documentation: theory and real examples




Särskild behörighet : After completion of the course the participants should be able to understand how to and document theirKursens lärandemål :

research in a way that ensures traceability and high quality according to the current legislation and rules. Among other things theparticipants will be able to utilise the electronic support systems for handling of research and research documentation available atKI. The participants should also be able to utilise the possibilities for large scale medical research that exist in Sweden.

The course includes an introduction to how research at KI should be documented and how electronic supportKursens innehåll : systems (ELN and LIMS) can be used to improve the documentation. Legislation regulating biobank samples and research registriesis presented and information is given regarding mandatory applications and how they can be used to complement the research. Theparticipants¿ own research (or, if necessary, course examples) will be used as examples and connects theory with practicalsessions that will make out the examination part of the course.

Lectures will be alternated with demonstrations and practical sessions for ELN, LIMS and application of the differentArbetsformer : parts of the course.

The examination of the course will be a written and oral presentation by the participants on how they can use whatExamination : they have learned during the course for their own research.

The whole course is mandatory. Absence from the practical sessions and/or the final presentationObligatoriska moment : (examination) must be compensated according to an agreement between the course responsible person/examiner and theparticipant in order to avoid a ¿non-pass-grade¿.

15 - 20Antal studenter : If the number of applicants exceeds the maximum number of students a selection will be based on time spentUrval av studenter :

as a doctoral student (with an advantage for those who have been registered for the longest time) and the motivation given by theapplicant for why he/she would like to participate in the course and how the course can help them in their doctoral studies.

The course will be held both in Huddinge and Solna. Ytterligare information :

Kursansvarig : Cecilia BjorkdahlInstitutionen för medicinsk epidemiologi och biostatistik08-524 872 [email protected]

Kontaktpersoner : -

Title : Computational neuroscience and Neuroinformatics




Särskild behörighet : At the end of the course the students will be able to describe the basic principles of modeling dynamic neuralKursens lärandemål :

processes and structural characteristics in the nervous system at both the subcellular-, the single cell- and neural network level. Thestudent should also be able to identify and use some selected neuroinformatics toolboxes.

In order to understand how complex systems, with a number of interactive processes function, modeling is aKursens innehåll : very important analytical tool in close interaction with experimental analyses. This course will introduce modeling at the intracellularmolecular level, for instance underlying synaptic plasticity, at the cellular level with the integrated interaction between different ionchannels, and finally the synaptic interaction within a network responsible for different aspect of behaviour and cognition. Also anoverview of standards for data screening, analysis, and storage of information in digital brain atlases is provided.

The course is two weeks full time, and is composed of lectures, demonstrations and laborations. Lectures byArbetsformer : international and Swedish scientists will present and discuss examples of modeling and databasing at the different levels oforganization as indicated above. There will also be practical demonstrations or laborations utilizing different modeling strategies. Anoverview of Neuroinformatics is provided through demos and lectures. Each participant will also try to identify how neuroinformaticsapproaches (modeling, databasing) can be of value for the student's own research field.

A written project report (around three pages) related to the value of neuroinformatics within the student's ownExamination : research field should be handed in at the end of the course. Peer assessment, where the course participants discuss each other'scontributions, is used to evaluate the result.

The graduate students are assumed to participate in all parts of the course. If the student is ill or unable toObligatoriska moment : take part, he/she should discuss with the course directors of how to compensate this.

12 - 50Antal studenter : Those with a PhD project where these approaches are applicable will be prioritized.Urval av studenter :

The course takes place at KI during two weeks. Most of the days there are lectures or demos/labYtterligare information : excercises both before and after the lunch break. The rooms where the lectures take place are to be annlounced later. Swedish aswell as international scientists participate, and the goal is to both learn the frontline approaches when it comes to informatics andcomputational approaches.

Kursansvarig : Jeanette HellgrenInstitutionen för neurovetenskap

[email protected]

Kontaktpersoner : Patrik KriegerInstitutionen för [email protected]

Title : Brain Imaging: Measurement of Brain Morphology using MagneticResonance Images




Särskild behörighet : After attending the course the graduate student should be able to: 1) Read the headers of the dicom imagesKursens lärandemål :

that contain all information about acquisition parameters. 2) Do image quality control. 3) Import and export images through thePACS system. 4) Convert between different image formats. 5) Run the basic commands from the main software available for themoment (SPM, Freesurfer, FSL, MNI pipeline etc.). 6) Initiate DTI image analysis. 7) Initiate fMRI image analysis.

The course focuses on in vivo image analysis for different neurodegenerative disorders by means of MRI. TheKursens innehåll : basic principles of MRI physics, including noise, inhomogeneities, optimization of pulse sequences will be introduced, together withfundamentals of digital image processing. The course covers the methodological approach of segmentation based on MR images,from manual outlining to completely automated brain atlas approaches. Deformation, voxel and tensor-based morphometry areaddressed, for single or multispectral data. Validity and reliability of the results will be discussed. Practical sessions will be part ofthe course and all presented methods will be available for the students to practice during the whole course period.

Lectures and seminars 5 full consecutive days. The students will perform group project including a criticalArbetsformer : assessment of relevant scientific literature.

The examination takes the form of a critical, in-depth discussion of the group project works, where a topic relevant toExamination : brain morphometry has been studied via a review of the scientific literature.

All parts of the course are mandatory. Absence is compensated for by a written summary of the literatureObligatoriska moment : the lecture is based on.

6 - 18Antal studenter : Students with a strong connection to MRI or fMRI brain imaging will be given precedence. Selection will beUrval av studenter :

performed from course relevance for research project and motivation.Please observe: The course will be given in english! Kontaktpersoner: Eva Örndahl, avd för sjukhusfysik,Ytterligare information :

C2-63 (visiting address R43) Karolinska univ sjukhuset Huddinge, 141 86 Stockholm, 08-58584807, e-mail:[email protected]. KI, Inst NVS, sektionen för klinisk geriatrik, Gabriela Spulber08-58582111, [email protected]. EricWestman, 08-58582889, [email protected]

Kursansvarig : Lars-Olof WahlundInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Kontaktpersoner : Anette EidehallInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Title : Writing Science and Information Literacy




Särskild behörighet : Demonstrate understanding of how to write an original scientific article and submit it for publication Kursens lärandemål :

Demonstrate ability to write other types of texts required for a scientific career Demonstrate ability to give, take, and make use ofconstructive criticism Demonstrate the ability to search and manage the medical sciences literature in a structured way Demonstratethe ability to use resources which facilitate choosing a journal to publish your research Describe aspects of post-publicationevaluation and processing of the medical sciences literature

Basic of scientific writing Writing an original scientific paper Supporting the text Writing in other contexts TheKursens innehåll : publication process Searching the literature Managing the literature Choosing a journal Evaluating published science KI-post-publication processing

This web-based course will be held using the learning management system PingPong. Content will be learnt withArbetsformer : various learning objects and learning practised by exercises. Formative feedback will be given by teachers/peer/self-assessment.Writing and IT skills will be developed.

The intended learning outcomes are assessed in the summative examination. Participants will write and rewrite aExamination : grant application and popular science summary based on teacher and peer feedback. Participants will also complete a number ofassignments which demonstrate their ability to use a number of relevant IT resources in a context of scientific communication.

There will be a number of obligatory tests and assignments to be completed.Obligatoriska moment : 18 - 22Antal studenter :

The selection for this general basic science course will be based on (1) your ranking of the applied course andUrval av studenter : (2) your registration date as a PhD student at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KIin your personal profile and that you have ranked the courses you have applied for. Please observe:To this course you have to reply by December the 4th 2011 at the latest after getting a preliminary acceptance offer.

This web-based course involves part-time (25%) study.Ytterligare information :


Berzelius 7B

17177Stockholm

Kontaktpersoner : -

Title : Electron tomography -reconstruction and image processing with IMOD




Särskild behörighet : After the course, the students can use IMOD software for reconstruction and image processing ofKursens lärandemål :

tomography data. Furthermore, the students will be able to describe the theory behind electron tomography, alignment andreconstruction methods, and critically evaluate and apply the methods learned on the course.

International experts in the field will share their knowledge on the selected topics, such as the theory behindKursens innehåll : tomography, alignment, reconstruction and image processing, by lectures and practical sessions. Also several research seminarswill be given by these experts about their tomography research. The practical sessions will provide opportunity for activeparticipation by the students.

The course is based on practical sessions, lectures and research seminars.Arbetsformer : Acquired knowledge and skills will be individually evaluated by practical computer exercises in the form of formativeExamination :

examination.All lectures, seminars and practical sessions are compulsory. Absence from obligatory moments isObligatoriska moment :

compensated according to the instructions of the course director.6 - 8Antal studenter :

Selection is based on the relevance of the course content for the doctoral project and the personal motivationUrval av studenter : letter to attend the course.

The course is organized at the KI Solna campus at CMB, seminar room D224, entrance von Eulers v 3.Ytterligare information : The course director is Lianne Den Hollander, email [email protected].


[email protected]

Kontaktpersoner : -

Title : Functional regulation in development and disease




Särskild behörighet : After the completed course, the participants will be able to describe the basic mechanisms of functionalKursens lärandemål :

regulation in non-disease cases from the gene level to the protein level, and at metabolite level, and compare and relate these todysregulation in disease. The participants will be able to describe and critically evaluate the weaknesses and strengths of thedifferent genomic technologies used in functional regulation studies.

Functional regulation in non-disease cases and dysregulation in diseases at gene level (genomic variationKursens innehåll : (SNPs), transcriptional variation, transcriptional regulation, post-transcriptional modifications, epigenomics, methylation, ncRNA,protein level (post-translational modifications) and at metabolite level. Novel technologies in gene level and protein level studies.Understanding development and disease through genomic technologies.

The course consists of lectures, discussion and seminars.Arbetsformer : The students will examined for knowledge and skills, individually based on the active participation in discussions andExamination :

groupwise with seminar presentations.The discussions and seminars are compulsory. Absence from compulsory parts is compensated accordingObligatoriska moment :

to the instructions from the course leader. 10 - 15Antal studenter :

Selection is based on the relevance of the course content for the doctoral project, and the personal motivationUrval av studenter : letter to attend the course.

The course is given in collaboration with the RIKEN Omics Science CenterYtterligare information : (http://www.osc.riken.jp/english/). The faculty consists of invited speakers from the RIKEN Omics Center and Karolinska Institutet.The course director is Dr. Carsten Daub at the RIKEN Omics Science Center. The course takes places at CMB seminar room A216,at KI Solna campus. Entrance Berzelius v 35.


[email protected]

Kontaktpersoner : -

Title : Developmental and Pediatric Endocrinology




Särskild behörighet : After the course the students will be able to: (i) Understand what the most important endocrine systems areKursens lärandemål :

during growth and development and how these systems act and what functions they have, (ii) integrate the obtained knowledge instudent¿s own doctoral projects, (iii) account for widely used models to assess regulation of growth and fertility.

The course aims to give students overview of endocrine systems and organs particularly important duringKursens innehåll : development and childhood. Accordingly, the course covers wide range of endocrine systems and glands related to pediatrics anddevelopment including GH/IGF system, thyroids, corticosteroids, sex hormones etc. Practical work will be focused on physiology ofgrowth and reproduction. By purpose the course is not covering fields of diabetes and obesity (specialized courses covering theseparticular fields are available within KI).

Lectures, formal and informal discussions, laboratory work, demonstrations and recommended literature. The mostArbetsformer : prominent local and international speakers are expected.

Examination is designed the way to facilitate use of obtained knowledge in student¿s own research projects. On theExamination : last day every student is supposed to give a 15 minutes presentation. The presentation should last 8 minutes (8-10 slides) ofstudent¿s own doctoral project following by 5 slides outlining connection between the project and any endocrinology subjectdiscussed during the course and the potential impact of this connection on the student¿s project.

Attending the lab work is compulsory. Up to two lectures can be missed, but every missed lecture has toObligatoriska moment : be compensated by literature work with a half-page summary.

8 - 16Antal studenter : Selection will be made based on the necessity for a student to attend the course. Urval av studenter :

Several outstanding researchers from USA, UK and Germany are expecting to give lectures.Ytterligare information :

Kursansvarig : Andrei ChaginEj satt

[email protected]

Kontaktpersoner : -

Title : Basic principles in molecular imaging for medical diagnostics throughmagnetic resonance physics




Särskild behörighet : --To understand the basic principles of magnetic resonance (MR) and how these are implemented inKursens lärandemål :

magnetic resonance imaging and spectroscopy --To distinguish between anatomic and molecular imaging through MR. --To beable to interpret an MR spectrum, in general terms. --To be able to explain why mathematics are essential for processing of MRsignals. --To be able to conceptualize and generate new ways of thinking about the possibilities offered by more advancedmathematical approaches for processing MR signals, and how these could potentially impact upon medical diagnostics.

The basic principles of magnetic resonance physics, as these apply to Magnetic Resonance Imaging (MRI) andKursens innehåll : Magnetic Resonance Spectroscopy (MRS) are presented. We review how biological signals are processed with data analyticaltechniques in current practice, the limitations of these techniques as they impact upon clinical diagnostics and the potential impact ofnew analytical methods for improving detection of malignant and other pathological processes. 1. Introductory lecture: Molecularimaging through MR physics/an overview 2. Basic principles of magnetic resonance imaging and magnetic resonance spectroscopy(MRS). 3. Fundamentals of signal processing for medical applications 4. Magnetic resonance spectroscopic imaging (MRSI), safetyconsiderations in MR. 5. Review and future perspectives: Advances in signal processing for MR physics

The basis of the Course is lectures in which the students should strive to actively participate with questions andArbetsformer : comments. Handouts of each lecture with ample space for note taking will be provided. Each lecture will be accompanied byhomework which the students should prepare and to which they will receive detailed feedback. Group work is encouraged, as longas each student ensures that he/she has thoroughly and completely grasped all the material. There will be one open afternoon perweek during which students can meet with the teachers to ask questions and explore areas of interest. Before the examinationthere will be a practice oral examination for each student to test his/her knowledge and receive feedback from the teachers. It is ourexperience that students who attend all the lectures, complete the reading and homework, actively participate and attend thepractice oral examination will be able to handle the examination in a satisfactory manner.

The examination is written, closed-book. It is our experience that students who attend all the lectures, complete theExamination : reading and homework, actively participate and attend the practice oral examination will be able to handle the examination in asatisfactory manner.

It is vital that the students attend all the lectures and complete the homework. If the student has a validObligatoriska moment : reason for an absence, he/she will need to complete the reading for the lecture, turn in the homework and then come to the openafternoon for review and feedback.

5 - 20Antal studenter : We will strive to admit all applicants who would like to enter the course. If there are more applicants thanUrval av studenter :

places, we will preference to those nearer completion of their PhD, and then will plan another course for those who are earlier in thedoctoral program.

The lectures are tentatively planned for Monday, Wednesday and Thursday afternoons, and one more dayYtterligare information : will be devoted to more interactive learning sessions, with a focus upon the practical exercises. The students will also be able tocommunicate with the teachers via email. The specific content of the course is outlined in the course contents. Please, be aware ofthat the course requires two weeks of full-time dedication from those attending the course, inclusive self study and teacher-guidedstudying and examination.

Kursansvarig : Karen BelkicInstitutionen för onkologi-patologi

[email protected]

Karolinska Institutet Helicopter Bldg P9PO Box 26017177Stockholm

Kontaktpersoner : Karen BelkicInstitutionen för onkologi-patologi

[email protected]

Karolinska Institutet Helicopter Bldg P9PO Box 260

17177Stockholm

Title : Introduction to R statistical analysis for biologists




Särskild behörighet : After the completion of the course, the participants will be able to make use of R for exploring and analyzingKursens lärandemål :

data sets. More specifically, the participants will be able to manage data sets, perform descriptive data analysis, generate plots forgraphical display of data, and to perform tests such as Regression and ANOVA. A very specific goal is to provide the participantswith a long-term tool and the guidelines for improving their knowledge on it.

Data sets and formats in R. Descriptive statistics. Graphical display of data. Classical tests. Regression,Kursens innehåll : ANOVA, Kruskal-Wallis. Experimental design. Graphical display of analysis. Use of documentation in R.

The course consists of lectures, computer excercises and project work.Arbetsformer : The acquired knowledge and skills will be examined in two ways: by successfully completing computer exercises andExamination :

by a individual project (analysis of a selected data set; which can be provided by the student).Attendance is compulsory in lectures and computer excercises. Absence from obligatory moments isObligatoriska moment :

compensated according to the instructions of the course director.10 - 15Antal studenter :

Selection is based on the relevance of the course content for the doctoral project, and the personal motivationUrval av studenter : included in the course application.

The course takes place at CMB at KI Solna campus, in the seminar room A216. Entrance Berzeliusv 35.Ytterligare information : The course director is Dr. David Gomez-Cabrero at the Department of Medicine, Solna. Email [email protected].


[email protected]

Kontaktpersoner : -

Title : Psykoneuroimmunologi




Särskild behörighet : At the end of the course the doctoral student will be able to: Describe the essential concepts inKursens lärandemål :

psychoneuroimmunology - the basic mechanisms by which the nervous, the endocrine and the immune system communicate, andwhy behavior is relevant in this communication. Critically comment on the literature in the field of psychoneuroimmunology Choosean adequate design for his/her own research questions in psychoneuroimmunology

The main content of the course is an overview of present knowledge in psychoneuroimmunology: the functionalKursens innehåll : relations between the nervous system, the endocrine system, the immune system and behavior.

Lectures will provide an overview of the essential concepts and the research in the different areas ofArbetsformer : psychoneuroimmunology for the use of the doctoral student in the preparation of the examination assignment. The doctoral studenthas access to supervision in the preparation of the written examination.

The examinations will be done in a mandatory seminar, with oral as well as written contributions from eachExamination : participant. The examination has two main parts: 1) Written presentation with a review of a selected topic ofpsychoneuroimmunology, as agreed upon with the course leader. 2) Written (2-3 pages) and oral presentation of a study that is wellmotivated in background of the current state of knowledge/lack of knowledge in psychoneuroimmunology.

Examination seminar. In case of absence from the scheduled examination seminar, another occasion forObligatoriska moment : examination can be arranged as agreed upon with the course leader.

5 - 30Antal studenter : If there is more applicants than maximum number of students a selection will be made from the givenUrval av studenter :

motivation to attend the course. Basic knowledge in neuroscience and immunology is strongly recommended. The course will be given 2Ytterligare information :

weeks full time during the given course period. Please observe: The course is given in english.

Kursansvarig : Anna Nixon AndreassonInstitutionen för klinisk neurovetenskap

[email protected]

Kontaktpersoner : -

Title : Microdosimetry - a course on principles and applications in radiationdosimetry biophysics and medical physics.




All PhD students with interest in Medical Physics, Radiation Physics, Radiation Biology. The student must beSärskild behörighet : familiar with classical radiation dosimetry quantities

The student will acquire theoretical knowledge and experimental skills in microdosimetry. The students at theKursens lärandemål : end of the course are expected to be able to describe the elements of the microdosimetry, decide on experimental and calculationmethods, and critically examine the literature. The knowledge and skills acquired from this course will equip the student to carry outrelevant research and measurements in the lab and the clinic.

Week 1: Lectures and tutorials Week 2: project Week 3: project Week 4: Project report and exam preparation Kursens innehåll : Week 4: Examination at the end of the week

This is a 4 weeks duration course, comprising: 1week lectures ( requires presence at KI, tutorials, exercises bothArbetsformer : theoretical and laboratory experiments); carrying out a project lasting 2 weeks (at home institution); 4th week writing project report,reading and exam preparation. The experimental part will focus on instrumentation and measurements. Tutorial part is intended toincrease knowledge and understanding of the subject. Tutorials will be conducted in the form of discussion of questions and theliterature, problem solving, and computer exercises. Faculty: Professor Hooshang Nikjoo, Radiation Biophysics Group, DepartmentOncology-Pathology, Karolinska Instituttet. Professor Lennar Lindborg, Radiation Biophysics Group, DepartmentOncology-Pathology, Karolinska Instituttet. Professor Paolo Colautti, INFN, Laboratori Nazionali di Legnaro, Viale dell¿Università 2,Legnaro, Italy. Dr Jan Lillhök, Swedish Radiation Safety Authority (SSM), Stockholm, Sweden. Professor Shuzo Uehara, School ofHealth Sciences, Kyushu University, Fukuoka, Japan. Professor Anthony Waker, University of Ontario Institute of Tecnology,Ontario, Canada. DAY 1 Session 1 (AM) Review of interaction of radiation with matter Objectives: The student will learn aboutphotons, electrons, and ions interactions with matter including track structure. Syllabus: (a) Interactions of charged particles withmatter (b) Track structure Session 2 (PM) Tutorial 1: Questions and exercises on the morning session; computer exercises on tracksimulation DAY 2 Session 3 (AM) Elements of Microdosimetry Objectives: The student will learn about Microdosimetry quantitiesand their moments and the relations between microdosimetric and classical quantities. Syllabus: (a) Stochastic Quantities (b)Relations to classical quantities Syllabus: Session 4 (PM) Discussions and calculations of different microdosimetric distributions, ofenergy imparted, lineal and specific energy, Poisson distributions in microdosimetry DAY 3 Session5 (AM) ExperimentalMicrodosimetry Objectives: The student will learn about microdosimetry measurements Syllabus: (a) Simulation principle of tissuevolumes. (b) Different detectors (c) Measurement methods (d) Calibration methods Session 6 (PM) Tutorial 3: Experimentalexercises and discussions. Measurements in a radiation therapy treatment room DAY 4 Session 7 (AM) Applications ofMicrodosimetry Objectives: The student will learn and discuss applications in radiation protection Syllabus: (a) Quantities in radiationprotection (b) Relation: Quality factor and lineal energy Session 8 (PM) Tutorial 4: Experimental exercises and discussions. Determination of a quality factor in the environment of a neutron source with different instruments DAY 5 Session 9 (AM) Applications of Microdosimetry Objectives: The student will learn and discuss applications in radiation therapy and radiationbiophysics/ biology Syllabus: (a) Weighting factor in therapy (ICRU/IAEA) (b) Microdosimetric approaches Session 10 (PM) Applications of Microdosimetry Objectives: The student will learn about applications to radiation biophysics/biology

1. Grading is based on tutors assessment during the week 1; project report; and the written examination. 2.Examination : Examination will take place at the end of week 4. It will be in writing to be administered/invigilated by the student'sinstitution/university. 2. A formal Project Report to be submitted to the project tutor in week 4.

All parts are comulsory. A maximum of 1 day lecture and tutorial can be missed due to illness. This can beObligatoriska moment : compensated by attending an additional tutorial session.

10 - 30Antal studenter : Selection of applicants are made by the date of registrationUrval av studenter :

The course will take place at the Karolinska Institutet. The duration is 4 weeks Week 1 (Monday -Friday):Ytterligare information : Lectures and tutorials. Lectures will be in the mornings, 8-11:30 hrs. Tutorials (experiment, theory and computation) in theafternoons, 13-17 hrs. Weeks 2-3: A project to be carried out at the student own institute/university. Projects are mostlytheoretical/computation unless the student has access to experimental setup. Week 4: Writing project report, and preparation forexamination. Week 4: Exam at the end of the 4th week at the student's home institution. FACULTY: Professor Hooshang Nikjoo(Karolinska Instituttet), Professor Lennart Lindborg (Karolinska Instituttet), Professor Paolo Colautti (INFN, Legnaro, Italy), Dr JanLillhök (Swedish Radiation Safety Authority, Stockholm), Professor Shuzo Uehara (Kyushu University, Japan), Professor AnthonyWaker (University of Ontario, Canada).

Kursansvarig : hooshang NikjooInstitutionen för [email protected]

Kontaktpersoner : -

Title : In vivo imaging of tissue transplanted into the anterior chamber of the eye.




Completion of the course ¿laboratory animal science¿ or equivalent is a plus but is not required forSärskild behörighet : acceptance to the course.

On completion of the course, the students will be able to explain the procedure for transplantation of tissueKursens lärandemål : into the anterior chamber of the eye, to use fluorescent probes for in vitro and in vivo imaging of cell function, to describe thelimitations of this particular imaging technique, and to select appropriate protocols for image analysis.

The course contains both theoretical aspects and laboratory training focusing on in vivo imaging, including theKursens innehåll : use of fluorescent probes for cell function, transplantation into the anterior chamber of the mouse eye, confocal microscopy for invitro and in vivo imaging, and image analysis.

The course is full time and is organized at the Rolf Luft Research Center for Diabetes and Endocrinology. TheArbetsformer : lectures will cover theory related to animal anesthesia and transplantation, in vivo imaging techniques, fluorescent probes, virustransduction of biosensors for cell function, microscopy, image processing and analysis. Students will form 3 groups for the practicalsessions. Each group will work on pancreatic islets isolation, virus transduction, in vitro imaging, transplantations of isolated isletsinto the anterior chamber of the mouse eye, in vivo imaging, and image analysis. Students will present their project and discuss theresults on the last day of the course. While the practicals will be focusing on project revolving around pancreatic islets due to theresearch field of our laboratory, the application of this technique to other tissues for specific research studies will be assessed in thelectures and discussions.

The learning outcomes will be assessed individually during the practical sessions and via a final examination in theExamination : form of student presentations of group projects.

Demonstrations, laboratory practicals, and project presentations are compulsory parts of the course. ToObligatoriska moment : compensate for absence, the student will have the opportunity to complement the laboratory training and to present the assignedgroup project.

7 - 9Antal studenter : Doctoral students registered at the Karolinska Institutet will be given priority. Additionally, the selection will beUrval av studenter :

based on the relevance of the course for the student¿s research project and the motivation given in the application to the course.The course is full time and is organized at the Rolf Luft Research Center for Diabetes and Endocrinology.Ytterligare information :

The lectures will cover theory related to animal anesthesia and transplantation, in vivo imaging techniques, fluorescent probes, virustransduction of biosensors for cell function, microscopy, image processing and analysis. Students will form 3 groups for the practicalsessions. Each group will work on pancreatic islets isolation, virus transduction, in vitro imaging, transplantations of isolated isletsinto the anterior chamber of the mouse eye, in vivo imaging, and image analysis. Students will present their project and discuss theresults on the last day of the course. While the practicals will be focusing on projects revolving around pancreatic islets due to theresearch field of our laboratory, the application of this technique to other tissues for specific research studies will be assessed in thelectures and discussions.

Kursansvarig : Erwin IlegemsEj satt

[email protected]

Kontaktpersoner : -

Title : Advanced diagnostic methods for hearing impaired children




Grundutbildning inom området hörsel, öron, språk eller talSärskild behörighet : After the course the students will be able to; Summarize the theoretical background of several diagnosticKursens lärandemål :

methods in hearing assessment of children Describe the background and possible causes of hearing loss and relate theassessment methods to different causes of hearing loss when possible Critically review current research in the area of hearingassessment in children Analyze and explain the pros- and cons of different methods for hearing assessment and diagnosis Suggestand argue for test batteries for assessment of hearing impairment in different patient cases Use and argue for current bestmethodology for examination and analysis of different methods for hearing assessment and diagnosis Identify needs for extendedknowledge in the area of hearing assessment and diagnosis

The course will offer a theoretical background regarding diagnoses of hearing impairment with focus on children.Kursens innehåll : Furthermore, methodology for advanced assessment of hearing impairment and actual research related to these methods will becritically reviewed and discussed. Practical, hands-on experiences will be offered in connection to some of the methods. Particularfocus will be given validity and reliability as well as clinical implementation of methods for assessment.

Independent reading as preparation for lectures. Teaching: lectures at campus. Practical hands-on exercises will beArbetsformer : offered for some of the methods. Use of the learning plat-form PingPong for distribution of materials. Search and critical review ofliterature related to a case.

Description and analysis of at least 3 different hearing assessment methods in a fictive or real case. A written essayExamination : with presentation of the case including a theory based discussion and conclusion with two clinically relevant research questions. Anoral presentation and discussion in the group.

Seminars and practical exercises are compulsory. If a student is not present at a compulsory moment, theObligatoriska moment : student will be given an extra written assignment as compensation.

4 - 15Antal studenter : Priority will be given to PhD students within the HÖST research education program.Urval av studenter :

Lectureres include experts in the field including PhD James Hall III from University of Florida USA. TheYtterligare information : course will be given partly as a distance course during the summer. Lectures seminars and practical exercises will be concentratedto week 23 and 24 (11th to 21st of June). Examination will take place in the end of August.

Kursansvarig : Åsa SkjönsbergInstitutionen för klinisk vetenskap, intervention och teknik

[email protected]

Kontaktpersoner : Ann-Christin JohnsonInstitutionen för klinisk vetenskap, intervention och teknik

[email protected]

Title : Transplantation immunology



ForskarnivåNivå : Department of Medicine, HuddingeKursansvarig institution :

IngenSärskild behörighet : After the course, each student is expected to be able to: - Discuss immunological principles of relevance toKursens lärandemål :

transplantation and relate those to normal immunological reactions. - Relate relevant methods used for investigations and diagnosisin relation to stem cell and organ transplantation. - Discuss the cutting-edge of preclinical transplantation research. - Discussdiagnostic principles before and after transplantation that are under development. - Give a historical perspective of clinical andpreclinical transplantation. - Reflect over the future of clinical transplantation immunology.

The aim of the course is to give preclinical and clinical doctoral students within cell biology, immunology,Kursens innehåll : transfusion medicine, hematology, transplantation surgery and internal medicine an updated and in-depth view of transplantationimmunology. For this purpose, the biology, diagnostics and therapy of diseases in which transplantation is a treatment modality willbe highlighted. An interdisciplinary view on research, diagnosis and therapy will be taken by integrating knowledged obtaind fromdifferent angles, such as cell biology, molecular biology, immunology, transfusion medicine, hematology, internal medicine,transplantation surgery and oncology. The course will thus connect preclinical and clinical transplantation research and focus on celltherapy, treatment of graft-versus-host disease and immunological monitoring after transplantation.

The course will encompass both preclinical to clinical research (bench-to-bedside) and will to some extent be builtArbetsformer : on real patient cases. Besides lectures, participants will be stimulated to interactive learning at seminars and discussions in smallergroups with clinically active teachers.

The examination of the intended learing outcomes will be both oral and written. The oral examination will be basedExamination : on the group work and will be done in the form of a presentation for the course. The written examination will consist of generalquestions that test the understanding of the corse content. During the oral presentation, each student is supposed to activelyparticipate.

Teaching in seminar form, case presentation and the examination are compulsory. In case such an activityObligatoriska moment : is missed, possibilities for complementary learning will be organized. The forms for such learning will be decided by the organizers.

8 - 25Antal studenter : In case the number of applicants increase the number of seats, a selection will be made based on an overallUrval av studenter :

evaluation of the reserach profile of the applicant, the personal motivation and the expected usefulness of the course of theapplicant.

The course will be held at Clinical Immunology F71, Karolinska University Hospital Huddinge. AYtterligare information : translational perspective on transplantation immunology will be provided based on lectures, case studies and teaching in seminarform. Lectures will be given by international guests as well as in-house experts in clinical and preclinical transplantation. The coursewill run during one week according to the following scheme: - Day 1 will be allocated to hematopoietic stem cell transplantation andfocus on the theory, research and clinical aspects. A focus will be on new treatments and immunological diagnostics before and aftertransplantation. - Day 2 will have a similar structure, but will focus on organ transplantation - Day 3 will focus on new forms oftreatments that are under development with both forms of transplantation, for example cell therapy of infections after transplantation,relaps of the disease and transplantation of pancreatic islets. - Day 4 will used for a group work, e.g. regarding the scientific basisfor a new treatment modality, the clinical and laboratory evaluation of a treatment principle, or a similar topic. The work will beconducted in smaller groups. Supervision will be provided. - Day 5 in the morning will be for examination.

Kursansvarig : Petter HoglundInstitutionen för medicin, [email protected]

Kontaktpersoner : -

Title : Cochlear Implants




Grundutbildning inom området hörsel, öron, språk eller talSärskild behörighet : After the course the students will be able to; Summarize the theoretical background of medical, behavioralKursens lärandemål :

and technical aspects of Cochlear Implants Describe and discuss the background and possible causes of hearing loss and relatethem to possible decisions for CI Understand, suggest and discuss the rehabilitation process after CI Analyze and explain the pros-and cons of different assessment methods during the rehabilitation process after CI Use and discuss current knowledge abouttechnical function, signal processing and programming of CI Critically review and be able to summarize current research in the areaof CI Identify needs for extended knowledge in the area of CI

The course is interdisciplinary and covers medical, behavioral and technical aspects of Cochlear Implants (CI).Kursens innehåll : The course will offer a theoretical background regarding all these aspects of CI. This includes decisions for operation, the process ofrehabilitation for adults and children as well as technical function, signal processing and programming. Practical experiences andauscultations at the clinic will be offered. Actual research related to these aspects will be critically reviewed and discussed.

Independent reading as preparation for lectures. Teaching: lectures and seminars at campus. Practical exercisesArbetsformer : and observations. Search and critical review of scientific literature. Part of the course will be held as a distance course using thelearning platform PingPong.

Description and analysis of at least one different aspect of CI based on scientific literature. A written essay includingExamination : a theory based discussion and conclusion with two clinically relevant research questions. An oral presentation and discussion in thegroup

Seminars and practical exercises and observations are compulsory. If a student is not present at aObligatoriska moment : compulsory moment, the student will be given an extra written assignment as compensation.

4 - 15Antal studenter : Priority will be given to PhD students with the area of the HÖST research education programUrval av studenter :

The course will be given as a part-time course spread out during VT2011. Partly as a distance course withYtterligare information : lectures at the Huddinge campus during 1-2 days/month.

Kursansvarig : Ann-Christin JohnsonInstitutionen för klinisk vetenskap, intervention och teknik

[email protected]

Kontaktpersoner : Ellika SchallingInstitutionen för klinisk vetenskap, intervention och [email protected]

Title : Non-coding RNA and cancer




Särskild behörighet : At the end of the course, the students are expected to be able to: - understand the diversity of non-codingKursens lärandemål :

RNAs and their importance in tumorigenesis and tumor progression. - describe the various methodologies for non-coding RNAresearch, account for applications and apply relevant approaches in their own projects..

Non-coding RNAs are key regulators of gene expression with important impact in many biological processes.Kursens innehåll : Recent research has identified different classes of non-coding RNA and their roles in cancer development and progression. Throughshort introductory lectures and in-depth discussion of key papers from the recent literature, this course will cover an up-to-dateintroduction to the biogenesis of diverse non-coding RNAs (including small RNAs and long non-coding intergenic RNAs) and theirmechanisms of gene regulation, methodologies for non-coding RNA research, the expression and function of non-coding RNAs incancer development, and their potential clinical implications.

The course consists of lectures, seminars and problem-based discussions. In addition, the students are required toArbetsformer : submit a research proposal on a topic related to non-coding RNA and cancer.

The examination of the course includes: (1) attendance of all lectures and seminars, (2) completion and participationExamination : in problem-based discussion, and (3) reviewing and presenting research proposal related to non-coding RNA.

The students are expected to attend all lectures and seminars, as well as to complete all assignments. InObligatoriska moment : the case of absence, the student will be asked to compensate by completing another written assignment given by the courseorganizer.

10 - 20Antal studenter : Criteria for selection will be based on the relevance of the course to the student's research project and theUrval av studenter :

personal motivation for participation in this course.This full-time course will be held at Center for Molecular Medicine L8:01, Karolinska UniversityYtterligare information :

Hospital-Solna. The lecturers include several outstanding researchers in the field.

Kursansvarig : Weng-onn LuiInstitutionen för molekylär medicin och [email protected]

Kontaktpersoner : -

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