Karin Johansson ICT for Health DG Information Society & Media European Commission Infrastructures...

Karin Johansson

ICT for HealthDG Information Society & Media

European Commission

Infrastructures use, requirements & prospect in

ICT for health domain

Outline

• ICT for Health research activities

• Relevant Grid-related activities• Where are we going in the

short/medium term?• Where do we go beyond FP7?

WHO ARE WE? ICT for Health (eHealth) Unit, European Commission

Information Society and Media DG

• eHealth unit:– established in 1989– supported to date > 450 projects worth > € 1 Billion– currently funds eHealth projects (€ 100 Million/year)

• The vision (since 1994): “eHealth-enabled citizen-centred care” or equivalently “eHealth-enabled continuity of care”

• Today’s focus– R&D:

• Personal Health Systems• Patient Safety• Modelling and Simulation of Human Physiology and Disease

(Virtual Physiological Human)

– Support to deployment: eHealth Action plan, Large Scale Pilots, Lead market initiative, Recommendation on Interoperability of EHRs, Communication on Telemedicine (2009)

Budget for research supported by the ICT for Health unit in FP7

Overall € 340 M over 4 years (2007-2010)

– Personalisation of Healthcare• Personal Health Systems (PHS)

€ 72 M in 2007 - € 63 M in 2009

– Patient safety (PS) - avoiding medical errors

€ 30 M in 2007 - € 30 M in 2009

– Predictive Medicine – Virtual Physiological Human (VPH)

• Modelling/simulation of human physiology and disease

€ 72 M in 2007 - € 5 M in 2009 - € 63 M in 2010

Next work programme will cover 2011-2012 and will be published on CORDIS in Oct-Nov 2010.

Outline




Where are Grid activities most relevant?

• VPH – Need for data capacity originates from

biomedical informatics roots– Huge demand on

• Data storage/management• Computing power

• Patient Safety (PS)– Early detection of public health events– Re-use of EHR data for research

purposes

The Virtual Physiological Human is a methodological and technological framework that once established will enable the investigation of the human body as a single complex system.

One of the 12 pioneer projects in FP6, The VPH research roadmap developed by project STEP in 2007:

www.europhysiome.org - Personalised (patient-specific) healthcare solutions

- Early diagnostics & predictive medicine

- Understanding diseases for the first time across several biological levels

Based on the ideas of the International Physiome project

The Virtual Physiological Human (VPH) concept

http://www.europhysiome.org/

Virtual Physiological Human: a schematic picture

Knowledge of biological and physiologicalpathways, processes etc

Computational resources

Data access

Data processing

Modelling

Construction and/or refinement of models on different temporal and

spatial scales

Integration of models

Multiscale model

verification

Health care professionals

Hospital

PatientSpecific Data• -omics• imaging• clinical• pharma

Datamanagement

Prediction,Early Diagnosis,Treatment

Application

Clin

ical v

alid

atio

n

Patient

Technical focus: • Patient-specific computational modelling and

simulation of organs targeting specific clinical needs.

• Data integration and new knowledge extraction.

Clinical focus:• Simulation environments for surgery training,

planning and intervention.• Prediction of disease or early diagnosis.• Simulation and assessment of the efficacy and

safety of specific drugs.

First VPH Call: FP7 call 2

Results of the 1st VPH call: 15 FP7 projects

Networking NoE

Osteoporosis

IP

Alzheimer's/ BM & diagnosis STREPHeart /CV

disease STREP

Cancer STREP

Liver surgery STREP

Heart/ LVD surgery STREP

Oral cancer/ BM D&T STREP

CV/ Atheroschlerosis IP

Breast cancer/ diagnosis STREP

Vascular/ AVF & haemodialysis STREP

Liver cancer/RFA therapy STREP

Security and Privacy in VPH CA

Grid access CA

Heart /CV disease STREP

Industry

ClinicsReproduction from VPH NoE

Parallel VPH projects

http://www.euheart.eu/

http://hamam-project.org/cms/website.php

http://www.euheart.eu/

Second VPH call: FP7 call 4International Cooperation on VPH

Focus:

• Interoperability (interfaces databases, web services, mark-up languages, meta-data, ontologies)

• Tools and services for global cooperation (for modelling/simulation, curated models, interconnected libraries)

• International validation environment (joint verification of clinical relevance of models)

Budget: 5M€Results: 5 proposals selected, all of which include

international partners.

ICT for Patient safety

Focus of Call:• ICT for safer surgery

• ICT for integration of clinical research and clinical care

• ICT-enabled early detection of public health events

Budget: 30M€Results: 9 retained (2 IPs, 6 STREPs, 1 SA)But: Public health policy is mainly the responsibility

of Directorate General Health and Consumer (DG SANCO) projects

DEISA/PRACE Symposium – Amsterdam, NL ••• 14

eInfrastructure: the European HPC Service

PRACE

National/Regional

DEISA and EGI

National

Local


DEISA: ‘virtual’ HPC services

12 sites in 7 countries connected at 10 Gb/s

Over 22,000 CPUs with an aggregated peak performance of close to 1 Peta flops

Running larger parallel applications in individual sites

Enabling workflow applications with grid technologies (UNICORE)

Providing a global data management service

Extreme Computing Initiative

NGI-E NGI-I

NGI-Nordic States

NGI-DNGI-F

NGI-UKNGI-IRL

NGI-GR

NGI-P

NGI-CZNGI-A

NGI-NLNGI-PONGI-B

NGI-SK

Coordinating entity (EGI)

Key elements of new scheme: Coordination/pooling of National and European funding

for sustainable service provision and for more efficient planning of investments

Service provisioning beyond project cycles One-stop-shop service provisioning (including training)

to users who want to access grid-based resources

EGI_DS (Design study)

establishing new organisational model for sustainable grid service provisioning


PRACE: preparatory phase

Late 2009: 1PF in the top 5

Late 2010: 2 PF in the top 5; 1PF in the top 10

2011: 3 PF in the top 5; 2 PF in the top 10

2020: an exaflop in the top 5

Outline




Virtual Physiological Humanfuture activities

Keep the overall VPH goals: Early diagnostics & Predictive medicine Personalised (Patient-specific) healthcare solution

By means of: Modelling & simulation of human physiology and disease-

related processes Add emphasis on tools/infrastructure for biomedical

researchers

VPH in 2010 Call 6 expected to open November 2009 and to close in

April 2010 Budget 63M€

VPH infrastructureneeds

Demand for: Data management Computing power

Requirements (coupling research activities with applications)

No longer sufficient to make technological advances within the GRID research

Engage users Usability/user accessibility Routinely used in applied research in other domains (VPH and

others) Develop culture of sharing

VPH Call 6

Focus a):Patient-specific computer based models and simulation Multiscale models & simulation of organs/systems

targeting specific clinical needs. Better understanding of the functioning of the

organs and their pathologies aiming at prediction/early diagnosis.

Emphasis on: Integration of existing models Clinical benefits demonstrated Data acquisition, medical, clinical, bio research (if

needed) < 25% Access to external computing facilities supported

VPH call 6

Focus b):ICT tools, services and infrastructures for bio-medical researchers to support at least 2 of the 3 activities: 1. Share data and knowledge 2. Jointly develop and share models/simulators3. Create collaborative environments

Interface to access to resources like Grid/HPC infrastructures

Ability to interface with existing medical research infrastructure

Complement/compatible with existing methods/standards to be suggested by VPH-NoE

VPH Call 6

Focus c) & d)Evaluation and assessment of VPH Projects w.r.t.

optimal use and contribution of Shared tools/infrastructure Clinical achievements Market potential/ penetration

Observatory on achievements and evolution of the broader BMI field (e.g. bioinformatics, Medical informatics, neuro-informatics):

Facilitate communication between projects Dissemination and trainingAim at: Sustaining cross collaboration among different fields Build on related NoEs.

Outline




Support projects cutting across research, innovation and deployment

As part of COM(2009)116 on « A strategy for ICT R&D Innovation in Europe », the Commission proposed

• Limited set of project cases that cut across the innovation chain

• Each project focused on specific characteristics of a pan-European service infrastructures addressing a specific societal goal

• To speed up the achievement of results there is a need to orchestrate efforts across research, innovation and deployment

– e.g. multi-financed large-scale initiatives in FP and CIP and national and regional actions including procurement of R&D and innovation

Example projects cutting across research, innovation and deployment

European Large Scale Action in ICT for Health

• ICT service infrastructure for personal healthcare– Specific societal goal: better integrated care and management

of chronic diseases at the point of need; continuous and personalised care …

– Specific characteristics: accuracy of measurements, remote control by health professionals, self-monitoring …

Contact persons

• DG Information Society and MediaUnit “ICT for Health”

http://ec.europa.eu/information_society/ehealth

• Virtual Physiological Human team:Joël Bacquet ([email protected])Karin Johansson ([email protected])Amalia Vlad ([email protected])

• eInfrastructure team:Enric Mitjana ([email protected])Maria Ramalho ([email protected])Bernhard Fabianek ([email protected])

Contact person for EGI-related part of FP7-INFRASTRUCTURES-2010-2:Monika Kacik ([email protected])

http://ec.europa.eu/information_society/ehealth

Karin Johansson ICT for Health DG Information Society & Media European Commission Infrastructures...

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