1. Brain-Computer Interface: Alexander Kaplan Headof Laboratory for Neurophysiology and Neuro-Computer Interfaces (NNCI Moscow) Contacts: [email_address] ;http:// brain.bio.msu.ru Lomonosov Moscow State University Faculty of Biology Dean of the Faculty:A cademician Mikhail P. Kirpichnikov Rebuilding radically new output of the Human Brain

2. Dr. Neal Miller (1909-2002 , USA ) ,the psychologist and neuroscientist, was one of the first research workers to demonstrate experimentally: The rats canvoluntarychangeown EEG In Dr. James Olds (1956)paradigm THE POWER OF MIND OVER MATTER i.e. MIND IS REAL POWER! THE KNOWLEDGE IS POWER, OK! What about MINDper se? 3.

A Brain-Computer Interface is a communication system that do not depend on peripheral nerves and muscles

[J. R. Wolpaw et al.Brain- computer interface technology: A reviewof thefirstinternational meeting, IEEETrans. Rehab. Eng., vol. 8, no. 2, pp.164173, 2000]

What is the Definition of BCI ? 4. In the last few years, a lot of labs begin to research the DIRECT communicate interface between brain and external environment Brain-Computer Interface (BCI).The purpose is for human to communicate with external device WITHOUT MUSCLES but DIRECTLYby using only the electrical brain activity - EEG. Peer-reviewed papers To this time we already published some basic papers on EEG computing for example:A.Ya.Kaplanet al.Nonstationary nature of the brain activity as revealed by EEG/MEG .In:Signal processing ,2005;85:21902212 and established new so calledsegmental approachin EEG analysis.BCI has seen increasing interest since 2000 5. 2005 et al. Our startup in BCI research in 2005 6. Neuroscience Letters Article in Press, Accepted Manuscript Copyright 2011 Published by Elsevier IrelandLt ________________________ EVENT-RELATED POTENTIALS IN A MOVING MATRIX MODIFICATION OF THE P300 BCI PARADIGM Sergei L. Shishkin, Ilya P. Ganin, Alexander Ya. Kaplan * M.V.Lomonosov Moscow State University, Faculty of Biology, Dept. of Human and Animal Physiology, Human Brain Research Group, 1/12 Leninskie Gory, Moscow 119991, Russia Our resent BCI research 7. Our nearest patents which incorporate the BCI technology 8.

A possible approach how to overcome

this disconnection isbypassingthe

damaged area by means of a

technical device which can detect

cortex commands and translate ones

to the commands for electronic devices

that replaced the muscle actions.

What is the idea of BCI in Neuroengineering ? The practical idea is very simple: when a disconnection of the main motor pathway occurs, themotor commandsgenerated in the cortex cannot travel through the pyramidal (spinal) tract to reach the executing organ, the muscles. 9.

The aim of BCI research is to establish a new augmented communication system that translates human intentions reflected by suitable brain signals into a control signal for an output device such as a computer.

Brain electrical activity or EEG is a most suitablesignal for BCI implementation

What is fundamental aim of the BCI technology ? 10. Psychological Effort (Intention) Modification of EEG Brain Signals Signal Features Classification Of Intent appropriate feature extraction appropriate feedback strategy user training computer training Environment Brain Computer What islogical scheme of BCI ? 11. Only in USA, more than 200,000 patients live with the motor consequences ofserious injury. Nicolelis, 2001 What is the motivation for BCI Research ? Motivation for Patients:is to give disable people to communicate, to operate prostheses, and even to operate wheelchairs using brain signals Only theINVASIVE SURGEON TECHNIQUEallows putting electrode into a very local area of a brain uniting a few neurons. These neurons could be belong to the cortex center, for example, for finger control. 12. Even if patients can not act, they also can use Brain-Computer Interface (BCI) to communicate with environment or control the devices. The EEG is the residual signal that can be used as command signal for HUNDRED THOUSANDS neurologically impaired patients with: -amyotrophic lateral sclerosis, -stroke,-old man with disabilities , -spinalinjur i es withlimb paralysis (tetraplegia etc.), -Locked-insyndrome What is EEG for BCI Research ? 13.

Philip Kennedy and Roy Bakay (Emory University in Atlanta) were first to install a brain implant in a human that produced signals of high enough quality to simulate movement.

Implant was installed in 1998 and the patient lived long enough to start working with the implant, eventually learning to control a computer cursor.

Kennedy, P.R., Bakay R.A.(1998) Restoration of neural output from a paralysed patient by a direct brain connection. Neuroreport. ;9(8):1707-11 John P. Donoghue, et al.Assistive technology and robotic control using motor cortex ensemble-based neural interface systems in humans with tetraplegia. J Physiol579.3 (2007) pp 603611 10 array of electrodes, each separated by 400 m What is invasive technology for BCI ? 14.

Communication

Neuroprosthetics

Environmental control

Robotics / Manipulators/ Mobility devices

Disability Level and Application:BCI for common people Most Disable people Health people 15.

For more than 40,000 years evolution adapted Homo sapiens brain abilities to control the environment only by means of muscular output.

A contemporary industry (high speed physical objects, processesand informational streams) make this output like bottleneck for human activity

Thought Driven Controlis not fantasy now.

Motivation BCI for Health people 16. How it is possible?EEG code for BCI

In 1990s researchesrealized that if a person canchange her own EEG therefore she can give the conscioussignals to BCI by means of EEG changes.

BCI should react to changes in EEG. If the person could produce two distinct changes in EEG it will make the binary code for BCI!

17.

Only few persons in the world are supported by BCI systems, WHY?:

Because contemporary BCItechnology is not practical, for ex.:

-a lot of time needs to one page typing for disable person

- there is no automation, BCI - actionis needed conscious effort at any moment

- etc

CONCLUSION: we have high level fundamental results but very pure application!

Very sensitive and still unsolved problems in BCI technology 18. 1. Feature extraction; 2. EEG changes classification; 3. Command translation; 4. Feedback Precision microelectronics Neuro- and Psychophysiology Mathematics and Programming Signal processing 1 2 3 4 Neuro- and Psychophysiology 1 Medicine 5 Precision microelectronics 2 Automatic control theory 6 Feedback Functional scheme of internal type BCI 19. Neurophysiology and Psycho- Mathematics Medicine Micro- electronics Statistics Signal processing Programming EEG analysisNeuro theory Mind-body problem Rehabilitation Surgery Clinics Amplifiers Wireless tech Chip design Nanotechnology for dry EEG sensorsand for money Themulti-disciplinary approachis a key for new generation of BCI technology 20.

One mental stateone BCI command

Too slow (24 bit per min 6-8 letters per min)

Low accuracy (no more then 75% for cursor control)

Unpredictable training results (how many days or months?)

What are the problems with internal typeBCI? 21. Alfa Theta Gamma t S(2) S(1) S(3) S(4) S(5) S(6) S( i) Dynamics of neuronal ensembles 22. Go left Go right Go ahead Go back 23. Subject New 1 Finding repeating spatial EEG patterns New 2 On-line EEG pattern classification Selection of functional commands only ABC Electronic drivers Neurofeedback ABC External objects New 3 P > 75% Multimodality Cognitions Emotions Executive part Neurofeedback part Pattern detection part USER part Creativity Moscow Brain-Computer Interface EEG Recognizingsingle channelEEG patterns Setting EEG commands 1, 2, 3, 4, 5 Instrumental conditioningtraining 24.

To design the cognitive training for EEG patter conditioning

To investigate what is the key cortex area for unconscious BCI control - EEG/fMRI study.

To design the adaptive algorithms for unconscious training with EEG pattern recognition

New microelectronics

How to realize the Moscow BCI? 25. (Donchin, 1988, 2000) Flashing of rows/columns containing the desired letter will elicit P300 response at vertex

Online testing :

• 15 or above trials averaging

• Correct letter - 56%of all trials

• Correct row/column 36%

• totally wrong 8%

Experiment Designfor externaltype BCI 26. P300 wave externaltype BCI P300 NCI lab in Moscow P300 driven typing ..I am Ivan Basul High-speed Moscow P300 BCI is only first step for real BCI spelling system 16-20 chatacters per minwith 97% accuracyin Moscow N NCI labis the world record at the moment! P300 27. Attention dissociation is big problem forexternaltype BCI Hybrid Brain-Gaze-Computer Interface (BGCI) is the final decision for Attention dissociation problem. 28. The integration eye tracker date with ongoing EEG datewill correctthe Attention dissociation problem 29. The toy car directly controlledby Dr. Kaplans Brain Kaplan A.Ya., et. al.Unconscious operant conditioning in the paradigm of brain-computer interface based on color perceptionIntern. J. Neuroscience, 2005 115:781802,Kaplan A.Ya., et. al.Nonstationary nature of the brain activity as revealed by EEG/MEG:methodological, practical and conceptual challenges Signal processing.Signal Processing 85 (2005) 21902212 Full-text papersof Dr. Kaplan are available at:http:// brain.bio.msu.ru 30. Motor execution vs. Movement imagination (lee_stbdayAY10.ppt) Execution Subject g3, 16-20 Hz Subject f7, 20-24 Hz time Imagination ERD ERS 500ms 31. Fundamental research in NNC Lab at Faculty of Biology Silicon Skolkovo supports theBCI research for aplications NPO ENERGIYA industry for limb prosthesis and manipulators OUR key project is EEG driven limb prosthesis and manipulators 32. Dr.Emanuel Donchin He designed first BCI for mind driven speller at 1988(University of South Florida) Dr.Christoph Guger ( Graz, Austria ) the owner of g.tec MedicalEngineering GmbH Dr. Philip Kennedy First implantation for BCI (Emory University) Academician Victor A.SadovnichiyRector of Lomonosov MSU (Russia) Partners for collaboration 33.