K27me2

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K27me2 EZH2 WT EZH2 WT K27me2 EZH2 WT A687V EZH2 K27me1 Supp Figure 3. Biochemical activity of PRC2 complexes containing WT, A687V, Y641N, or A677G EZH2 using a library of 125 histone H3 peptides containing H3K27. Each peptide possesses up to five post-translational modifications, such as lysine and/or arginine methylation; lysine acetylation; or phosphorylation of serine, tyrosine, and/or threonine. Y641N EZH2 A677G EZH2

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K27me1. K27me2. A687V EZH2. Y641N EZH2. A677G EZH2. K27me2. EZH2 WT. EZH2 WT. EZH2 WT. - PowerPoint PPT Presentation

Transcript of K27me2

Page 1: K27me2

K27me2

EZH2 WT EZH2 WT

K27me2

EZH2 WT

A687

V EZ

H2 K27me1

Supp Figure 3. Biochemical activity of PRC2 complexes containing WT, A687V, Y641N, or A677G EZH2 using a library of 125 histone H3 peptides containing H3K27. Each peptide possesses up to five post-translational modifications, such as lysine and/or arginine methylation; lysine acetylation; or phosphorylation of serine, tyrosine, and/or threonine.

Y641

N E

ZH2

A677

G E

ZH2