JOURNAL OF VIROLOGYVOLUME 36 0 NUMBER 3 0 DECEMBER 1980

EDITORIAL BOARDRobert R. Wagner, Editor-in-Chief (1982)University of Virginia School of Medicine,

Charlottesville

Dwight L. Anderson, Editor (1983)School of Dentistry,

University ofMinnesota,Minneapolis

David T. Denhardt, Editor (1982)University of Western OntarioLondon, Ontario, Canada

Harold S. Ginsberg, Editor (1984)Columbia UniversityNew York, N. Y.

Edward M. Scolnick, Editor (1982)National Cancer Institute

Bethesda, Md.

David Baltimore (1981)Amiya K. Baaerjee (1982)

jeaneth 1. Berns (1982)IH. L Bishop (1982)DavlW9otstein (1982)Michael A. Bratt (1980)Dennis T. Brown (1981)Ahmad 1. Bukhari (1981)Purnell Choppin (1980)John M. Coffin (1980)Richard W. Compans (1982)Geoffrey M. Cooper (1981)Nicbolas R. Cozzarelli (1980)Clive Dickson (1981)Walter Doerfier (1980)Harrison Echols (1981)Elvera Ebrenfeld (1980)Robert N. Eisenaa (1982)Suzanoe U. Emerson (1980)Lynn Enquist (1981)Erw* . Fleissner (1980)S. Jaze Flint (1981)Robert M. Friedman (1982)Larry M. Gold (1982)Hidesaburo Hanafusa (1980)William S. Hayward (1981)John J. Holland (1981)

Nancy Hopkins (1980)Calderon Howe (1982)Alice S. Huang (1981)D. C. Kelly (1982)Tlomas J. Kelly, Jr. (1982)George Khoury (1981)Jonathan A. King (1981)David W. Kingsbury (1982)Lloyd M. Kozloff (1982)Robert M. Knig (1980)Robert A. L i 1981)Richard A. Lerner (1981)Myron Levine (1982)Tomas Lindahl (1981)David M. Livingston (1980)Ronald B. Luftig (1981)Robert MartiDn (1981)Lois K. Miller (1982)Robert C. Miller (1980)Gisela Mosig (1982)Bernard Moss (1980)Joseph S. Pagano (1982)J. Thomas Parsons (1980)Ulf G. Petterson (1980)Lennart Philipson (1981)Peter G. W. Plagemann (1980)Craig R. Pringle (1980)

Fred Rapp (1981)Dan S. Ray (1980)M. E. Reicn (1982)Bernard E. Reilly (1980)Willham S. Robinson (1980)BenardRo (1982)Roland R. Rueckert (1982)Norman P. Salman (1981)Joseph Sambook (1982)Priscila A. Schaffer (1981)Sondra S ger (1980)Phlp A. Sharp (1982)Aaron J. Shatkln (1982)Saul J. Silverstein (1982)Lee D. Simon (1981)Kai Simn (1981)Alan E. Smith (1980)Patricia G. Spear (1981)F. William Studier (1981)Lawrence S. Sturnan (1982)Donald F. Summers (1982)William C. Summers (1980)John M. Taylor (1981)Howard M. Temin (1982)David C. Ward (1980)Ernest Winocour (1982)Julius Youngner (1982)

Giseila Pollock, Acting Managing EditorSusan Birch, Production Editor

1913 I St., NW, Washington, DC 20006

Albert Balows, President (1980-1981)J. Mebsen Joseph, Secretary

The Journal of Virology (ISSN 0022-538X), a publication ofthe American Society for Microbiology, 1913 1 St., NW, Wash-ington, DC 20006, is devoted to the dissemination offundamentalknowledge concerning viruses of bacteria, plants, and animals.Inves ators are invited to submit reports of original research inall areas of basic virology, including biochemistry, biophysics,genetics, immunology, morphology, and physiology. Instructionsto Authors are published in the January issue each year. TheJournal is issued monthly, four volumes per year. The nonmem-ber subscription price is $90 per year, single copies are $8. Themember subscription price is $21 per year. Correspondencerelating to subscriptions, reprints, defective copies, availability ofback issues, lost or late proofs, disposition of submitted manu-

and general editorial matters should be directed to theASS Publications Office, 1913 I St., NW, Washington, DC20006 (area 202 833-9680).

ai* : idbm 119*lkA ,-1 E 11IrA ff,fl ( I fo

EX OFFICIOFrederick C. Neidhardt, President-Elect (1980-1981)

Brinton M. Miller, Treasurer

Second-class postage paid at Washington, DC 20006, and atadditional mailing offices.Made in the U.S.A.Copyright i 1980, American Society for Microbiology.All Rights Reserved.

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Author IndexAAwine, James C., 701

:jBErson, Steven M., 676

Bastow, K. F., 746Battula, Narayana, 709Bearzotti-Le Berre, Monique,

652Bellamy, A. R., 894Bernard, Jacqueline, 652Boettiger, David, 883Brown, Dennis T., 775Buetti, Elena, 734

4ai, Enzo, 816Chowdhury, Kamal, 878Clark, Daniel R., 766,~i~,Fulmer, 872

Cowra, Jon H., 796Cooper, Geoffrey M., 684Courtney, Richard J., 665

lxy, G., 746De, arun K., 847de Kinkelin, P., 652Demsey, Anthony, 872Diggelmann, Heidi, 734Dorsch-Hasler, Karoline, 837

Eberle, R., 665Erwin, Christine, 775

Faras, A. J., 805Feitelson, Mark A., 787

Fujinaga, Kei, 639

Gerlich, Wolfram H., 787Grandgenett, Duane P., 889Groner, Bernd, 734

Halbert, Donald N., 860Hanafusa, Hidesaburo, 676Harris, Tixnothy J. R., 659Harvey, J. D., 894Hayward, William S., 676Heilman, Carole A., 878Howley, Peter M., 878Hu, James, 692Huang, Alice S., 756Hulen, Christian, 633Hynes, Nancy E., 734

Israel, Mark A., 878

Jenkins, Nancy A., 684

Kawka, Douglas, 872Khoury, George, 701Krzyzek, R. A., 805

Labedan, Bernard, 633Lambert, Dennis M., 837Lau, A. F., 805Law, Ming-Fan, 878Lazzarini, Robert A., 796Legault-Demare, Jean, 633

Lodish, Harvey F., 719

Marion, Patricia L., 787Mason, William S., 829Mbuy, Gustave N., 837Minson, A. C., 746Mitchell, R. L., 805

Nayak, Debi P., 847Neel, Benjamin G., 676

Peters, Gordon G., 692Pignatti, Pier F., 816Pons, Marcel W., 837Porter, Mary, 719

Ralph, S. J., 894Rao, Donald D., 756Raskas, Heschel J., 860Rentier-Delrue, Francoise, 878Robinson, William S., 787Rosenberg, Naomi E., 766

Sawada, Yukiharu, 639Schiff, Ron D., 889Seal, Geeta, 829Spector, David J., 860Steimer, Kathelyn S., 883Summers, Jesse, 829

Takemoto, Kenneth K., 878Todaro, George J., 709

Wildy, P., 746Witte, Owen N., 766

ACKNOWLEDGMENT

The following have served as invited special reviewers for the Journal during 1980, and their

help is greatly appreciated.

Stuart AaronsonJosef AloniJames AlwineChristian AnfinsenRalph B. ArlinghausJ. Thomas AugustRichard AxelJohn P. BaderCarrado BaglioniL. Andrew BallClaudio BascilicoRobert BassinKaren BeemonThomas BenjaminPeter B. BergetAlan BernsteinEdward BirkenmeierJ. Michael BishopKlaus BisterDavid BoettingerMichael BotchanSidney BreeseSean BrennanDoris BucherClarence A. BullerJanet ButelR. CallahanAllan M. CampbellRobert CardiffEsther ChangRobert ChanockCraig CohenMarc CollettDonald L. CourtJohn DahlbergJames E. DarnellVittorio DefendiE. DeHarvinAlbert DeLeuMelvin DePamphilisMichael DexterRavi DharHeidi DiggelmannGiampiero di MayorcaDino DinaJoseph DipaoloGideon DreyfusEdward J. DuboviPeter H. DuesbergWalter EckhartJohn ElderRay EricksonMary K. EstesLeonard EvansHung FanAnthony J. FarasBernard FieldsPeter FischingerWilliam FolkC. Fred FoxHeinz Fraenkel-ConratRichard M. Franklin

Mike FriedRobert J. GaloE. Peter GeiduschekJohn GemnRaymond GildenRobert GoldbergNeil GoldmanMichael GottesmanT. GrafAngus F. GrahamDuane GrandgenettAllan GranoffMaurice GreenBeverly GriffinNeal B. GromanPeter GrussAshley HaaseGordon HagerStephen C. HarrisonJanet HartleyWilliam HaseltineIan H. HolmesJerard HorowitzPeter HowleyS. HughesAnthony HunterJames IhleMark IsraelGilbert JayGeorge JohnsonRichard JohnsonWolfgang K. JoklikDavid KabatPaul J. KaesbergRobert KamenWilliam KamenC. Yong KangAlbert KapikianAlbert KaplanKathleen KennedyS. I. T. KennedySaul KitEdward KuffChing-Juh LaiMichael LaiLloyd LawPaul LebowitzPeter LengyelArnold J. LevineA. LindbergMaxine LinialPaul S. LovettRex E. LovrienDouglas LowyRoderick MacLeodManley MandelJack ManiloffJames ManleyStuart MarcusG. Steven MartinMalcolm A. MartinHeather D. Mayor

Philip McAllisterD. James McCorquodaleJoseph MelnickTrudy G. MorrisonK. MulliniFrederick A. MurphyJohn R. MurphyDaniel NathansPaul E. NeimanRobert NewarthAbner L. NotkinsRobert NowinskiStephen O'BrienPaul O'DonnellMichael B. A. OldstonePeter M. PaleseAmon PanetTakis PapasArthur PardeeWade ParksIra PastanJanice PeroJacques PerraultSidney PestkaWilliam A. Petri, Jr.Ralf F. PettersonPaula PithaRobert PollackAlan R. PriceCarol PrivesAl RabsonUlf RappJames A. RawlesJohn ReeveDaniel RifldinRichard RobertsBetty Jo RobertsonHarriett RobinsonJohn K. RoseJeff RosenNaomi RosenbergEllen RothenbergWallace P. RoweSandra RuscettiM. SarngadharanAndreas S. ScheidCharles ScherrMilton SchlesingerJeffrey SchlomManfred SchweigerBartholomew M. SeftonRoland SeifPeter ShankJoel B. SheffieldThomas ShenkCharles SherrThomas ShihRobert W. SimpsonMaxine SingejAnna Skalka<D. Peter SnustadMitchell Sogin

S0

William A. StarkJesse SummerRaquel SussmanWaclaw SzybalskiPeter TegtmeyerSatvir TevethiaRobert E. ThachGeorge TodaroThomas A. TrautnerStephen TronickPhilip TsichlisGeorge Vande WoudeJames L. Van EttenHarold Varmus

Leland VelicerAnne K. VidaverPeter K. VogtVolker VogtDon WalkerDuard L. WalkerL. H. WangHuber R. WarnerRobert E. WebsterRobert A. WeinbergI. B. WeinsteinPeter WeisbeekSherman WeissmanHeiner Westphal

Sue WicknerEvelyn WilkinS. G. WilkinsonMark WillinghamGary A. WilsonEckard WimmerOwen WitteRobert YangWen YangHamish YoungHoward A. YoungJack J. ZakowskiPaul ZamecnikHarold Zur Hausen

AUTHOR INDEX

VOLUME 36

AI-Shaiiwari Abdul J. N., 120Alwine, James, 143Alwine, James C., 701Anderson, Dwight L., 236Anderson, Steven M., 676

Bacchetti, Silvia, 361Bacheler, L. T., 254Baltimore, David, 547Baluda, M. A., 317, 325Barwise, A. H., 224Bastow, K. F., 746Battula, Narayana, 709Bearzotti-Le Berre, Monique,652

Bellamy, A. R., 894Bernard, Jacqueline, 652Berns, Anton J. M., 254Bia, Frank J., 245Bishop, J. Michael, 50, 575Bister, Klaus, 617Boettiger, David, 883Bosselman, R. A., 254Briskin, M. J., 325Brown, Dennis T., 775Bucher, D. J., 586Buetti, Elena, 734Burnette, W. Neal, 280

Cardiff, Robert D., 109Carlson, Karin, 1Cassai, Enzo, 816Cassingena, Rolando, 295Chang, Esther H., 408Chattopadhyay, Sisir K., 499Chen, J. H., 162Chowdhury, Kamal, 566,878Clark, Daniel R., 766Coca-Prados, M., 353Coffnan, Robert, 547Cohen, Gary H., 429Collins, Fulmer, 872Condra, Jon H., 796Cooper, Geoffrey M., 684Copeland, Terry D., 115Courtney, Richard J., 665Curtis, Peter J., 133

Darby, G., 746Davis, J. F., 586De, Barun K., 847DeFeo, Deborah, 408de Kinkelin, P., 652DeLorbe, William J., 50Demsey, Anthony, 872Diebold, Mary A., 541

Diggelmann, Heidi, 734di Mayorca, Giampiero, 480Dimock, Kenneth, 361Dixon, Richard A. F., 189Doerfiler, W., 22Doerfler, Walter, 41Dorsch-Hasler, Karoline, 837Duesberg, P. H., 591Duesberg, Peter H., 617

Eberle, R., 665Eckhart, Walter, 125Ehrenfeld, Ellie, 387Eick, Dirk, 41Eisenberg, Roselyn J., 429Eisenman, Robert N., 62Ellis, Ronald W., 408Emerson, Suzanne U., 309Enjuanes, Luis, 299Erwin, Christine, 775

Fan, H., 254Fanning, Thomas G., 109Fanshier, Lois, 575Faras, Anthony J., 236, 805Feitelson, Mark A., 787Fenno, James, 280Fong, Caroline K. Y., 245Friis, R. R., 22Fujinaga, Kei, 337, 639

Garon, Claude F., 566Gerlich, Wolfram H., 787Gerling, David, 264Gershowitz, Alan, 601Gilmer, Tona M., 271Goldbach, Rob, 366Goldman, Neil, 143Gomatos, Peter J., 556Goodman, Howard M., 50Grandgenett, Duane P., 115, 889Green, Michael R., 79Gregoriades, Anastasia, 470Griffin, James D., 488Grigoriev, V. B., 586Groman, N. B., 526Groner, Bernd, 734Gruss, Peter, 143

Haas, Martin, 606Haberer, Klaus, 264Halbert, Donald N., 860Hall, Dwight H., 103Hanafusa, Hidesaburo, 676Harris, Timothy J. R., 659Harvey, J. D., 894

i

Hawke, Mary, 506Hayward, William S., 676Heilman, Carole A., 395, 878Highfield, Peter E., 271Hillyard, R. L., 325Holland, John J., 627Horak, Ivan, 299Horodyski, Frank M., 627Horwich, Arthur, 125Howley, Peter M., 395, 878Hsiung, G. D., 245Hsu, M.-T., 353Hu, James, 692Huang, Alice S., 756Hulen, Christian, 633Hunsmann, G., 291Hynes, Nancy E., 734

Ihle, James N., 299Ishimoto, Akinori, 18Israel, Mark A., 395, 566, 878Ito, Yoshiaki, 566

Jay, Gilbert, 143Jenkins, Nancy A., 684Johnson, K. M., 465Jongstra, Jan, 606Jovanovich, Susan, 595

Kawka, Douglas, 872Keith, Jerry M., 601Kelley, J. Michael, 309Kelly, D. C., 224Kennedy, S. Ian T., 440Kharitonenkov, I. G., 586Khoury, George, 143, 701Kieff, Elliott, 506Kiggans, James O., Jr., 181Kiley, M. P., 465King, Walter, 506Kingpford, Laura, 309Klimenko, S. M., 586Koop, Allen H., 125Krueger, Robert G., 533, 541Krzyzek, Richard A., 236, 805

Labedan, Bernard, 633Lai, M. H. T., 254Lambert, Dennis M., 837Lander, Marilyn R., 499Lau, A. F., 805Lavialle, Christian, 295Law, Ming-Fan, 395,878Iarini, Robert A., 796Lee, John C., 299Lee, W.-H., 591

ii AUTHOR INDEX

Lee, Wen-Hwa, 617Legault-Demare, Jean, 633Leung, Wai-Choi, 361Light, Susan E., 566Linial, Maxine, 62, 280, 450Livingston, David M., 488Lodish, Harvey F., 719Long, Deborah, 429Lowy, Douglas R., 408Luciw, Paul A., 50

Maandag, E. C. Robanus, 254Maniloff, Jack, 264Marion, Patricia L., 787Martin, G. S., 591Maryak, Jean M., 408Mason, William S., 62, 829Mbuy, Gustave N., 837McKennett, M. A., 254Minson, A. C., 746Mitchell, R. L., 805Moore, N. F., 224Morrison, T. G., 171Moscovici, Carlo, 575Moss, Bernard, 601Muzyczka, Nicholas, 611

Nayak, Debi P., 847Neel, Benjamin G., 676

O'Callaghan, Dennis J., 204Oroszlan, Stephen, 115

Parsons, J. Thomas, 271Pass, Franklin, 236Pater, Alan, 480Pater, Mary M., 480Pedrali-Noy, Guido, 457Peters, Gordon G., 692Pignatti, Pier F., 816Pons, Marcel W., 837Porter, Mary, 719Pritchett, Randall F., 152Puma, John P., 109

Raab-Traub, Nancy, 506Rabin, M., 526Rafield, Lori F., 271Ralph, S.-J., 894Rao, Donald D., 756Raskas, Heschel J., 860Rawlins, Dan R., 611Regnery, R. L., 465Rentier-Delrue, Francoise, 878Reynolds, Fred H., Jr., 374Rezelman, Geertje, 366Rhoades, Marc, 622Richards, Oliver C., 387Robinson, P. J., 291Robinson, Robin A., 204Robinson, William S., 787Roeder, Robert G., 79Rohrschneider, Larry, 280Rosenberg, Naomi E., 766Rotter, Varda, 547Rowe, Wallace P., 499Rubin, Harvey, 488Russell, Diane L., 103

Sargent, R. Geoffrey, 103Sarkar, Nurul H., 556Sawada, Yukiharu, 639Schaffer, Priscilla A., 189Schiff, Ron D., 889Schirrmacher, V., 291Schneider, J., 291Schwartz, Joanna, 622Scolnick, Edward M., 408Seal, Geeta, 829Seif, Roland, 421Shank, Peter R., 450Shih, Thomas Y., 408Showe, Michael K., 220Simmons, Daniel T., 519Simpson, D., 171Smiley, James R., 361Smith, Paul F., 120Souza, L. M., 317, 325Spadari, Silvio, 457Spangler, Gregory J., 488Spector, David J., 860

Spilling, C. R., 224Spriggs, Dale R., 533, 541Stabel, S., 22Stabel, Silvia, 41Stamatos, Nicholas M., 556Steimer, Kathelyn S., 883Stephenson, John R., 374Stern, David F., 440Suarez, Horacio G., 295Summers, Jesse, 829Summers, William C., 245

Takemoto, Kenneth K., 878Thomas-Powell, Ann L., 506Todaro, George J., 709Traub, Franz, 220Trofatter, Kenneth F., 103

Vance, Ralph B., 204Van de Ven, Wim J. M., 374van Driel, Roel, 220Van Kammen, Albert, 366Varmus, Harold E., 50v.d. Putten, H., 254Vennstrom, Bjorn, 575Verma, Inder M., 254Vidali, G., 353Villarreal, Luis P., 595

Wagner, Robert R., 93Wahl, Jeffrey M., 622Walker, I. O., 224Watts, Susan L., 236Wiktor, Tadeusz J., 133Wildy, P., 746Witte, Owen N., 547, 766Wunner, William H., 133

Yang, Den-Mei, 181Yang, Wen K., 181Yoshida, Kouichi, 337Young, Howard A., 408

Zakomirdin, J. A., 586Zakowski, Jack J., 93

J. VIROL.

SUBJECT INDEX

VOLUME 36

Abelson murine leukemia virusantibodies against P50, 547mutants deficient in kinase activity and lymphoid

cell transformation, 766P120-associated protein kinase activity, 374transformation-defective mutants, 374

Acholeplasma laidlawiimycoplasma virus MVL3, 264

Acholeplasma laidlawii strain JAlcellular components, 120mycoplasma virus type 2, 120

Adeno-associated virusgenome transcripts, 79mapping of major RNAs, 79

Adenovirushuman cell line 293, 860regulation of integrated sequences, 860

Adenovirus type 7DNA fragment-transformed cells, 337unique mRNA species from early region 1, 337

Adenovirus type 12DNA integration sites, 22hamster cell line T637 revertants as tools in analysis

of integration patterns, 41mRNA mapping, 639transformed hamster cells and hamster tumor cells,

22Adenovirus type 2-simian virus 40

chimeric splice junction, new, 143hybrid viral mRNA, 143

AKR virusendogenous ecotropic virus ofMus musculus molos-sinu, 499

Amber codonconstruction in simian virus 40 T-antigen gene, 611site-directed mutagenesis, 611

Amino acid sequence analysisavian myeloblastosis virus reverse transcriptase sub-

units, 115Anogenital wartshuman papillomavirus, 236

Aphidicolinherpes simplex virus DNA polymerase inhibition,

457vaccinia virus DNA polymerase inhibition, 457

Aphthovirusesfoot-and-mouth disease viruses, 659RNA nucleotide sequences, 659

Asymmetric recombinationnondefective Rous sarcoma virus, 591

Avian acute leukemia virusesphosphorylation of nonstructural proteins, 617

Avian erythroblastosis virusmolecular cloning of genome, 575mRNA's, 676oncogenic virus recovery, 575transfection of chicken cells, 575

Avian Fujinami sarcoma virusphosphorylation of nonstructural proteins, 617

Avian infectious bronchitis virusmapping intracellular RNA species to genome, 440multiplication strategy, 440

Avian myeloblastosis virusacute myeloblastic leukemia-associated restriction

endonuclease fragments, 317amino acid sequence analysis of reverse transcrip-

tase subunits, 115chicken cells, 162endogenous, 162genome identification, 317, 325restriction endonuclease analysis of DNA from A

proviral recombinants and leukemic myeloblastclones, 325

Avian oncovirusmutant (SE21Q16) deficient in genomic RNA, 450provirus deletion, 450

Avian retroviruspp32 DNA endonuclease, partial phosphorylation in

vivo, 889Avian retrovirusespolymerase proteins, synthesis and processing, 62wild-type and mutant, 62

Avian sarcoma viruscircular DNA molecules, 50molecular cloning and characterization, 50molecular cloning of closed circular DNA, 271nonpermissive and permissive cells, 805protein kinase activity, pp6OsC and src, 805recombinant clones, structural and biological char-

acterization, 271reverse transcriptase, 692selective packaging of tRNA's, 692

Baboon type C viral DNAinfectious, 709integration sites, 709physical map, 709

Bacteriophage lambdaMoloney murine leukemia viral DNA, molecular

cloning, 254Bacteriophage T4

cytosine-containing DNA, 1endonuclease SalI, KpnI, BglI, and BamHI, 1gene 63, suppressors of mutations, 103genetic map and map of cleavage sites, 1preheat proteinase zymogen, 220RNA ligase, 103tail fiber attachment, 103

Bacteriophage T5deletion mutant, 622heterogeneity, 633second-step-transfer DNA injection, 633

BALB/c miceMoloney leukemia virus, 299

.m

iv SUBJECT INDEX

splenic T-cell lymphoma cell line, 299unique defective type C virus, 299

BALB/c myeloma retrovirusesimmunological analysis, 533mink cell focus-inducing activity, 541peptide mapping, 533ppl2 structural protein, 533

BHK-21 cellsSindbis virus membrane protein distribution, 775

Bottom component RNAcowpea mosaic virus, 366cowpea protoplasts, 366

Chicken cellsendogenous avian myeloblastosis virus information,

162Circular DNA molecules

avian sarcoma virus, 50molecular cloning and characterization, 50

Coronavirusavian infectious bronchitis virus, mapping intracel-

lular RNA species to genome, 440multiplication strategy, 440

Corynebacteriophagesheteroimmune, 526superinfection exclusion, 526

Cowpea mosaic virusbottom component RNA expression, 366cowpea protoplasts, 366

Cowpea protoplastsbottom component RNA expression, 366cowpea mosaic virus, 366

CV1 cellsnuclear transcript leakage, 595simian virus 40-infected, 595

Cyanogen bromide-cleaved peptidescarbohydrate content, 309vesicular stomatitis virus glycoprotein, 309

Cycloheximideherpes simplex virus thymidase kinase transcripts,

361CytomegalovirusDNA nucleotide sequence heterogeneity, 152strains Towne and AD169, 152

Cytosine-containing DNAbacteriophage T4, 1

Defective interfering particlesvesicular stomatitis virus, 627vesicular stomatitis virus RNA synthesis, 756

Deletion mutantbacteriophage T5, 622

Densonucleosis virusstructural proteins, 224

Dinucleotide sequencesvaccinia virus mRNA's, 601

DNA cloninggenomic, 395human papilloma virus, 395

DNA fragmentcloned, 566oncogenic potential, 566pBR322, 566polyoma virus, 566

J. VIROL.

DNA injectionbacteriophage T5, 633second-step-transfer, 633

DNA integration sitesadenovirus type 12, 22transformed hamster cells and hamster tumor cells,

22DNA nucleotide sequence heterogeneity

cytomegalovirus strains Towne and AD169, 152DNA polymerases

aphidicolin inhibition, 457herpes simplex virus, 457vaccinia virus, 457

DNA-protein complexesherpes simplex virus, 816

Ebola virusvirion nucleic acid, 465

Endonucleases Sall, KpnI, Bgil, and BamHIbacteriophage T4 cytosine-containing DNA, 1genetic map and map of cleavage sites, 1

Envelope assembly mutantRous sarcoma virus, 883

Epstein-Barr virusrestringently infected, growth-transformed cell line,

506viral RNA, 506

Equine herpesviruseshamster embryo cells, 204oncogenic transformation, 204

Equine herpesvirus type 1persistent infection and oncogenic transformation ofhamster embryo cells, 204

Escherichia colipolyoma small T antigen, 125

Focus formationecotropic murine leukemia viral genome, 18S+L- mink cells, 18

Foot-and-mouth disease virusesRNA nucleotide sequences, 659

Friend murine leukemia viruspossible cell surface receptor, 291viral envelope glycoprotein complexes, 291

Gene 63bacteriophage T4, 103RNA ligase, 103suppressors of mutations, 103tail fiber attachment, 103

Glycoproteins gA and gBherpes simplex virus type 1, 665

Glycoproteins gD and gCherpes simplex virus type 1, 429synthesis and processing, 429

GPXVnew endogenous herpesvirus of guinea pigs, 245

GR micemouse mammary tumor virus, selective amplifica-

tion, 109Ground squirrel hepatitis virus

surface antigens, 787Guinea pigs

VOL. 36, 1980

herpesvirus, new endogenous, 245

Hamster cell line T637adenovirus type 12-transformed, 41revertants as tools in analysis of integration pat-

terns, 41Hamster cells

adenovirus type 12 DNA integration sites, 22transformed, 22

Hamster embryo cellsoncogenic transformation by equine herpesvuses,

204Hamster tumor cells

adenovirus type 12 DNA integration sites, 22Harvey murine sarcoma virus

rat genetic sequences, dual evolutionary origin, 408HeLa cells

defective interfering influenza viruses, 847persistent infection, 847

Hepatitis B virusPekin ducks, 829

Herpes simplex viruscycloheximide, 361DNA polymerases, mechanism of inhibition by aphi-

dicolin, 457DNA-protein complexes, 816thymidine kinase transcripts, 361

Herpes simplex virus type 1glycoproteins gA and gB, 665glycoproteins gD and gC, synthesis and processing,

429immediate early protein VP175, 189temperature-sensitive mutants, fine-structure map-

ping and functional analysis, 189Herpes simplex virus type 2

reversion to thymidine kinase-negative phenotype,746

thymidine kinase gene-carrying cells, 746Herpesvirus

biological and molecular characterization of newendogenous, 245

guinea pigs, 245Histone modifications

simian virus 40 nucleoprotein complexes, intracel-lular forms, 353

Human amnion cellscloned human polyoma virus JC DNA, 878

Human cell line 293adenovirus-transformed, 860

Human hepatitis B virusPekin ducks, 829surface antigens, 787

Human papilloma viruscloning of genomic DNAs, 395homologous polynucleotide sequence analysis, 395

Human papovavirusRF virus, arrangement of the genome, 480

Human polyoma viruscloned JC DNA, 878human amnion cells, 878

Hybrid viral mRNAadenovirus type 2-simian virus 40, 143chimeric splice junction, new, 143

Influenza

SUBJECT INDEX v

M protein interaction with viral lipid and phospha-tidylcholine vesicles, 470

Influenza virusM-protein incorporation into liposomes, 586

Influenza virusesdefective interfering, 847MDBK and HeLa cells, 847persistent infection, 847

5-Iodo-2'-deoxyuridine and mitomycin Ccooperative effect, 295simian virus 40-Chinese hamster kidney cell inter-

action, 295

JC virushuman amnion cell transformation, 878

Leukemiaacute myeloblastic, 317, 325avian myeloblastosis virus genome, 317, 325restriction endonuclease analysis of DNA, 325restriction endonuclease fragments, 317

Lymphomagenesisabrogation, 606radiation leukemia virus-induced, 606

MDBK cellsdefective interfering influenza viruses, 847persistent infection, 847

Membrane-associated proteinslocalization by hydrophobic membrane probes and

cross-linking reagents, 93vesicular stomatitis virus, 93

Mink cell focus-inducing activityBALB/c myeloma retroviruses, 541

Mink S+L- cellsecotropic murine leukemia viral genome, 18focus formation, 18

Minus-strand RNA3' end, 387heterogeneity, 387poliovirus replicative form, 387

Molecular cloningavian erythroblastosis virus genome, 575avian sarcoma virus closed circular DNA, 271bacteriophage lambda, 254Moloney murine leukemia viral DNA, 254oncogenic virus recovery, 575recombinant clones, structural and biological char-

acterization, 271transfection of chicken cells, 575

Moloney leukemia virusBALB/c mice, 299splenic T-cell lymphoma cell line, 299unique defective type C virus, 299

Moloney murine leukemia virusmolecular cloning ofDNA in bacteriophage lambda,

254Mouse mammary tumor virusGR mice, 109proviral DNA characterization, 734selective amplification, 109site-specific molecular clones, 734

M proteininfluenza, 470

vi SUBJECT INDEX

viral lipid and phosphatidylcholine vesicles, 470M-protein

influenza virus, 586mRNA mapping

adenovirus type 12, 639mRNA's

avian erythroblastosis virus, 676mRNA species

adenovirus type 7 early region 1, 337unique, 337

mRNA translationrabies virus, 133Xenopus laevis oocytes, 133

Multiplication strategycoronaviruses, 440RNA-containing viruses, 440

Murine leukemia virusecotropic, 18focus formation by S+L- mink cells, 18

Murine sarcoma viruscore polyprotein cleavage, 872defective particles, structure of and alterations to,

872envelope proteins, 872

Murine type C retroviruscovalently closed circular DNAs, 181cycloheximide-treated cells, 181

Mus musculus molossinusAKR virus, 499endogenous ecotropic virus, 499

Mycoplasma virus MVL3Acholeplasma laidlawii, 264adsorption, capping, and release, 264

Mycoplasma virus type 2Acholeplasma laidlawii strain JAl cellular com-

ponents, 120

Newcastle disease virusglycoprotein synthesis, stability, and cleavage in

absence of glycosylation, 171Nonstructural proteins

avian acute leukemia viruses, 617avian Fujinami sarcoma virus, 617phosphorylation, 617

Nuclear transcriptsleakage in simian virus 40-infected CV1 cells, 595

Nucleic acidsrespiratory syncytial virus, 837

Nucleocapsid assemblyvesicular stomatitis virus-infected permeable cells,

796Nucleoprotein complexes

histone modifications, 353simian virus 40 intracellular forms, 353

Nucleotide sequencesaphthovirus RNAs, 659foot-and-mouth disease virus RNAs, 659

Oncogenic transformationequine herpesviruses, 204hamster embryo cells, 204

P50Abelson murine leukemia virus-induced tumors, 547

antibodies, 547Papillomavirus

anogenital warts, 236human, 236

Papovavirushuman, 480RF virus, arrangement of the genome, 480Tau antigen characterization, 519

pBR322polyoma DNA fragment, 566

Pekin ducksvirus related to human hepatitis B virus, 829

Phosphorylationavian retrovirus pp32, 889

Poliovirusminus-strand RNA, 3'-end heterogeneity, 387replicative form, 387

Polycytidylate-dependent RNA polymerase activitysmall reovirus-specific particle, 556

Polymerase proteinsavian retroviruses, wild-type and mutant, 62synthesis and processing, 62

Polynucleotide sequence analysishomologous, 395human papilloma virus, 395

Polyoma viruscell transformation, 421cleavage with BamHI and EcoRI, 566cloned DNA fragment oncogenic potential, 566cloned human JC DNA, 878early gene region, 566Escherichia coli, 125human amnion cells, 878pBR322, 566small T antigen, 125

ppl2BALB/c myeloma retroviruses, 533immunological analysis, 533peptide mapping, 533

pp32 DNA endonucleaseavian retrovirus, 889partial phosphorylation in vivo, 889

Protein kinase activityAbelson murine leukemia virus transformation-de-

fective mutants, 374avian sarcoma virus-infected cells, 805impaired P120-associated, 374pp60 and src, 805

Protein synthesistranslational control, 719vesicular stomatitis virus infection, 719

Proviral DNAcharacterization with site-specific molecular clones,

734mouse mammary tumor virus, 734

Provirusesexogenously acquired, 684Rous-associated virus-0, 684

Rabies virusmRNA translation, 133Xenopus laevis oocytes, 133

Radiation leukemia virus

J. VIROL.

VOL. 36, 1980

lymphomagenesis abrogation, 606Rainbow trout

viral hemorrhagic septicemia, 652Rat genetic sequences

dual evolutionary origin, 408Harvey murine sarcoma virus, 408

ReceptorsFriend murine leukemia virus, 291

Reovirusparticle with polycytidylate-dependent RNA po-

lymerase activity, 556subunit structure of spike, 894

Replicationvesicular stomatitis virus-infected permeable celLs,

796Replicative form

minus-strand RNA, 3'-end heterogeneity, 387poliovirus, 387

Respiratory syncytial virusnucleic acids, 837

Retroviruscovalently closed circular DNAs, 181cycloheximide-treated cells, 181murine type C, 181

RetrovirusesBALB/c myeloma, 533mink cell focus-inducing activity, 541peptide mapping and immunological analysis of

ppl2, 533Reverse transcriptase

avian sarcoma virus, 692packaging of tRNA's, 692

Reverse transcriptase subunitsamino acid sequence analysis, 115avian myeloblastosis virus, 115

RF virusgenome arrangement, 480

RNA expressionbottom component, 366cowpea mosaic virus, 366cowpea protoplasts, 366

RNA ligasebacteriophage T4 gene 63, 103

RNA synthesisdefective interfering particle transcription and rep-

lication, 756vesicular stomatitis virus, 756

Rous-associated virus-0exogenously acquired proviruses, 684

Rous sarcoma virusasymmetric recombination between deletion mu-

tants, 591envelope assembly mutant, 883nonconditional mutants, 280nondefective, 591viral glycoproteins, synthesis and processing, 280

Simian virus 40amber codon construction by site-directed mutagen-

esis, 611CV1 celLs, 595histone modification, 353low-molecular-weight virus-encoded T antigen, 488nuclear transcript leakage, 595

SUBJECT INDEX vui

nucleoprotein complexes, intracellular forms, 353small RNA mapping and characterization of synthe-

sis, 701spliced and unspliced late 19S RNAs, 595T-antigen gene, 611Tau antigen characterization, 519

Simian virus 40-Chinese hamster kidney cell interac-tion

5-iodo-2'-deoxyuridine and mitomycin C coopera-tive effect, 295

virus replication, 295Sindbis proteinsmembrane association, 775

Sindbis virusmembrane protein distribution, 775wild-type virus- and maturation-defective mutant-

infected BHK-21 cells, 775Small T antigenEscherichia coli, 125polyoma virus, 125

Spike proteinreovirus, 894

Superinfection exclusionheteroimmune corynebacteriophages, 526

Surface antigensground squirrel hepatitis virus, 787human hepatitis B virus, 787

Tail fiber attachmentbacteriophage T4 gene 63, 103

T antigenlow-molecular-weight, 488simian virus 40-transformed cells, 488

Tau antigenscharacterization, 519papovavirus-transformed cells, 519simian virus 40-infected monkey cells, 519uninfected monkey cells, 519

T-cell lymphoma cell lineMoloney leukemia virus-induced splenic, 299unique defective type C virus, 299

Temperature-sensitive mutantsfine-structure mapping, 189functional analysis, 189herpes simplex virus type 1 immediate early proteinVP175, 189

Thymidine kinase geneherpes simplex virus type 2, 746reversion to thymidine kinase-negative phenotype,

746Thymidine kinase transcripts

cycloheximide, 361herpes simplex virus, 361

Transformation-defective mutantsAbelson murine leukemia virus, 374impaired P120-associated protein kinase activity,

374Translational control

protein synthesis, 719vesicular stomatitis virus infection, 719

tRNA packagingavian sarcoma virus, 692reverse transcriptase, 692

Type C virus

viii SUBJECT INDEX

Moloney leukemia virus-induced splenic T-cell lym-phoma cell line, 299

unique defective, 299

Vaccinia virusdinucleotide sequences, 601DNA polymerases, mechanism of inhibition by aphi-

dicolin, 457mRNA's synthesized in vitro, 601

Vesicular stomatitis viruscyanogen bromide-cleaved peptides, 309defective interfering particles, 627, 756glycoprotein, 309membrane-associated proteins, localization by hy-

drophobic membrane probes and cross-linking re-agents, 93

nucleocapsid assembly, 796permeable cells, 796persistently infected cells, 627replication, 796RNA synthesis, 756

transcription and replication, 756translational control of protein synthesis, 719

Viral DNAinfectious baboon type C, 709integration, 709physical map, 709

Viral glycoproteinssynthesis and processing in Rous sarcoma virus

nonconditional mutants, 280Viral hemorrhagic septicemia

polypeptide synthesis, 652rainbow trout, 652thermoresistant virus variant, 652wild-type virus strain, 652

Virion nucleic acidEbola virus, 465

VP175herpes simplex virus type 1, 189

Xenopus laevisrabies mRNA translation in oocytes, 133

J. VIROL.

JOURNALOF

VIROLOGY

VOLUME 36

WASHINGTON, DC 20006

1980

JOURNAL OF VIROLOGYVOLUME 36 0 1980

EDITORIAL BOARDRobert R. Wagner, Editor-in-Chief(1982)University of Virginia School ofMedicine,

Charlottesville

Dwight L. Anderson, Editor (1983)School of Dentistry,

University of Minnesota,Minneapolis

DavW T. Denhardt, Editor (1982)University of Western OntarioLondon, Ontario, Canada

Harold S. Ginsberg, Editor (1984)Columbia UniversityNew York, N. Y.

Edward M. Scolnick, Editor (1982)National Cancer Institute

Bethesda, Md.

David Baltimore (1981)Amiya K. Banerjee (1982)Kenneth 1. Berms (1982)David H. L. Bishop (1982)David Botstein (1982)Michael A. Bratt (1980)Dennis T. Brown (1981)Abmad 1. Bukhari (1981)Purnell Cboppin (1980)John M. Coffin (1980)Richard W. Compans (1982)Geoffrey M. Cooper (1981)Nicholas R. Cozzarelli (1980)Clive Dickson (1981)Walter Doerfler (1980)Harrison Echols (1981)Elvera Ehrenfeld (1980)Robert N. Eisenman (1982)Suzanne U. Emerson (1980)Lynn Enquist (1981)Erwin J. Fleissner (1980)S. Jane Flint (1981)Robert M. Friedman (1982)Larry M. Gold (1982)Hidesaburo Hanafusa (1980)William S. Hayward (1981)John J. Holland (1981)

Nancy Hopkins (1980)Calderon Howe (1982)Alice S. Huang (1981)D. C. Kelly (1982)Thomas J. Kelly, Jr. (1982)George Khoury (1981)Jonathan A. King (1981)David W. Kingsbury (1982)Lloyd M. Kozioff (1982)Robert M. Krug (1980)Robert A. Lazzarini 1981)Richard A. Lerner (1981)Myron Levine (1982)Tomas Lindahl (1981)David M. lvingston (1980)Ronald B. Luftig (1981)Robert Martin (1981)Lois K. Miller (1982)Robert C. Miller (1980)Gisela Mosig (1982)Bernard Moss (1980)Joseph S. Pagano (1982)J. Thomas Parsons (1980)Ulf G. Petterson (1980)Lennart Philipson (1981)Peter G. W. Plageman (1980)Craig R. Pringle (1980)

Fred Rapp (1981)Dan S. Ray (1980)M. E. Reichmann (1982)Bernard E. Reilly (1980)William S. Robinson (1980)Bernard Rolzman (1982)Roland R. Rueckert (1982)Norman P. Salzman (1981)Joseph Sambrook (1982)Priscilla A. Schaffer (1981)Sondra Schlesinger (1980)Phillip A. Sharp (1982)Aaron J. Shatkin (1982)Saul J. Silverstein (1982)Lee D. Simon (1981)Kd Simons (1981)Alan E. Smith (1980)Patricia G. Spear (1981)F. William Studier (1981)Lawrence S. Sturman (1982)Donald F. Summers (1982)WEUam C. Summers (1980)John M. Taylor (1981)Howard M. Temin (1982)David C. Ward (1980)Ernest Winocour (1982)Julius Youngner (1982)

Gisella Polock, Acting Managing EditorSusan Birch, Production Editor

1913 I St., NW, Washington, DC 20006

Albert Balows, President (1980-1981)J. Mehsen Joseph, Secretary

The Journal of Virology (ISSN 0022-538X), a publication ofthe American Society for Microbiology, 1913 I St., NW, Wash-ington, DC 20006, is devoted to the dissemination offundamentalknowledge concerning viruses of bacteria, plants, and animals.Investigators are invited to submit reports of original research inall areas of basic virology, including biochemistry, biophysics,genetics, immunology, morphology, and physiology. Instructionsto Authors are published in the January issue each year. TheJournal is issued monthly, four volumes per year. The nonmem-ber subscription price is $90 per year; single copies are $8. Themember subscription price is $21 per year. Correspondencerelating to subscriptions, reprints, defective copies, availability ofback issues, lost or late proofs, disposition of submitted manu-scripts, and general editorial matters should be directed to theASM Publications Office, 1913 I St., NW, Washington, DC20006 (area 202 833-9680).

EX OFFICIOFrederick C. Neidhardt, President-Elect (1980-1981)

Brinton M. Miller, Treasurer

Second-class postage paid at Washington, DC 20006, and atadditional mailing offices.Made in the U.S.A.Copyright i) 1980, American Society for Microbiology.All Rights Reserved.

The code at the top of the first page of an article in this journalindicates the copyright owner's consent that copies of the articlemay be made for personal use, or for personal use of specificclients. This consent is given on the condition, however, that thecopier pay the stated per-copy fee through the Copyright Clear-ance Center, Inc., P.O. Box 765, Schenectady, New York 12301,for copying beyond that permitted by Sections 107 and 108 ofthe U.S. Copyright Law. This consent does not extend to otherkinds of copying, such as copying for general distribution, foradvertising or promotional purposes, for creating new collectiveworks, or for resale.

Volume 36 Contents for October 1980 Number 1

Animal VirusesLack of Focus Formation of S+L- Mink Cells by the Ecotropic

Murine Leukemia Viral Genome. AKINORI ISHIMOTO ....... 18-21Integration Sites of Adenovirus Type 12 DNA in Transformed Ham-

ster Cells and Hamster Tumor Cells. S. STABEL, W. DOER-FLER, * AND R. R. FRIIS .......... ......................... 22-40

Revertants of Adenovirus Type 12-Transformed Hamster Cell LineT637 as Tools in the Analysis of Integration Patterns. DIRKEICK, SILVIA STABEL, AND WALTER DOERFLER* ............. 41-49

Molecular Cloning and Characterization of Avian Sarcoma VirusCircular DNA Molecules. WILLIAM J. DELORBE,* PAUL A.Luciw, HOWARD M. GOODMAN, HAROLD E. VARMUS, AND J.MICHAEL BISHOP ...................................... 50-61

Synthesis and Processing of Polymerase Proteins of Wild-Type andMutant Avian Retroviruses. ROBERT N. EISENMAN,* WILLIAMS. MASON, AND MAXINE LINIAL ....... ..................... 62-78

Transcripts of the Adeno-Associated Virus Genome: Mapping of theMajor RNAs. MICHAEL R. GREEN AND ROBERT G. ROEDER* 79-92

Localization of Membrane-Associated Proteins in Vesicular Stoma-titis Virus by Use of Hydrophobic Membrane Probes and Cross-Linking Reagents. JACK J. ZAKOWSKI AND ROBERT R.WAGNER .......................... 93-102

Selective Amplification of Mouse Mammary Tumor Virus in Mam-mary Tumors of GR Mice. THOMAS G. FANNING, JOHN P.PUMA, AND ROBERT D. CARDIFF* .......................... 109-114

Amino Acid Sequence Analysis of Reverse Transcriptase Subunitsfrom Avian Myeloblastosis Virus. Terry D. Copeland, DuaneP. Grandgenett, and Stephen Oroszlan* ...... ............... 115-119

Interaction of Mycoplasma Virus Type 2 with Cellular ComponentsofAcholeplasma laidlawii Strain JAl. ABDUL J. N. AL-SHAM-MARI* AND PAUL F. SMITH ......... ........................ 120-124

Expression of the Gene for the Polyoma Small T Antigen in Esche-richia coli. ARTHUR HORWICH, ALLEN H. KooP,* AND WAL-TER ECKHART ............................................. 125-132

Rabies mRNA Translation in Xenopus laevis Oocytes. WILLIAM H.WUNNER,* PETER J. CURTIS, AND TADEUSZ J. WIKTOR ...... 133-142

New Chimeric Splice Junction in Adenovirus Type 2-Simian Virus40 Hybrid Viral mnRNA. GEORGE KHOURY,* JAMES ALWINE,NEIL GOLDMAN, PETER GRUSS, AND GILBERT JAY ..... ...... 143-151

DNA Nucleotide Sequence Heterogeneity Between the Towne andAD169 Strains of Cytomegalovirus. RANDALL F. PRITCHErr . 152-161

Expression of Endogenous Avian Myeloblastosis Virus Informationin Different Chicken Cels. J. H. CHEN ....... ............. 162-170

Synthesis, Stability, and Cleavage of Newcastle Disease Virus Gly-coproteins in the Absence of Glycosylation. T. G. MORRISON*AND D. SIMPSON ............... .......................... 171-180

Covalently Closed Circular DNAs of Murine Type C Retrovirus:Depressed Formation in Cells Treated with Cycloheximide EarlyAfter Infection. WEN K. YANG,* DEN-MEI YANG, AND JAMES0. KIGGANS, JR................... 181-188

* Asterisk refers to person to whom inquiries regarding the paper should be addressed.

CONTENTS

Fine-Structure Mapping and Functional Analysis of Temperature-Sensitive Mutants in the Gene Encoding the Herpes SimplexVirus Type 1 Immediate Early Protein VP175. RICHARD A. F.DIXON AND PRISCILLA A. SCHAFFER* ...... ................. 189-203

Oncogenic Transformation by Equine Herpesviruses. II. Coestablish-ment of Persistent Infection and Oncogenic Transformation ofHamster Embryo Cells by Equine Herpesvirus Type 1 Prepa-rations Enriched for Defective Interfering Particles. ROBIN A.ROBINSON, RALPH B. VANCE, AND DENNIS J. O'CALLAGHAN*. 204-219

Densonucleosis Virus Structural Proteins. D. C. KELLY,* N. F.MOORE, C. R. SPILLING, A. H. BARWISE, AND I. 0. WALKER .. 224-235

Anogenital Warts Contan Several Distinct Species of Human Pap-ilHlomavirus. RICHARD A. KRZYZEK,* SUSAN L. WATTS, DWIGHTL. ANDERSON, ANTHONY J. FARAS, AND FRANKLIN PASS ...... 236-244

New Endogenous Herpesvirus of Guinea Pigs: Biological and Molec-ular Characterization. FRANK J. BIA,* WILLIAM C. SUMMERS,CAROLINE K. Y. FONG, AND G. D. HSIUNG ..... ............. 245-253

Molecular Cloning of Unintegrated and a Portion of IntegratedMoloney Murine Leukemia Viral DNA in BacteriophageLambda. ANTON J. M. BERNS,* M. H. T. LAI, R. A. BOSSEL-MAN, M. A. MCKENNETT, L. T. BACHELER, H. FAN, E. C.ROBANUS MAANDAG, H. V.D. PUTTEN, AND INDER M. VERMA 254-263

Molecular Cloning of Avian Sarcoma Virus Closed Circular DNA:Structural and Biological Characterization of Three Recombi-nant Clones. PETER E. HIGHFIELD, LORI F. RAFIELD, TONAM. GILMER, AND J. THOMAS PARSONS* ...... ................ 271-279

Synthesis and Processing of Viral Glycoproteins in Two Noncondi-tional Mutants of Rous Sarcoma Virus. MAXINE LINIAL,*JAMES FENNO, W. NEAL BURNETTE, AND LARRY ROHR-SCHNEIDER ............................................... 280-290

Possible Cell Surface Receptor for Friend Murine Leukemia VirusIsolated with Viral Envelope Glycoprotein Complexes. P. J.ROBINSON,* G. HUNSMANN, J. SCHNEIDER, AND V. SCHIRR-MACHER ................................................. 291-294

Simian Virus 40-Chinese Hamster Kidney Cell Interaction. V. Co-operative Effect of 5-Iodo-2'-Deoxyuridine and Mitomycin C inthe Enhancement of Virus Replication in Infected Cells.HoRACIo G. SUALREZ,* CHRISTIAN LAVIALLE, AND ROLANDOCASSINGENA .............................................. 295-297

Bacterial VirusesCorrelation Between Genetic Map and Map of Cleavage Sites for

Sequence-Specific Endonucleases SAIl, KpnI, BgiI, and BamHIin Bacteriophage T4 Cytosine-Containing DNA. KARINCARLSON ................................................ 1-17

Suppressors of Mutations in the Bacteriophage T4 Gene Coding forBoth RNA Ligase and Tail Fiber Attachment Activities.DWIGHT H. HALL,* R. GEOFFREY SARGENT, KENNETH F. TRo-FATTER, AND DIANE L. RUSSELL .......... ................. 103-108

Probable Localization of the Bacteriophage T4 Prehead ProteinaseZymogen in the Center of the Prehead Core. ROEL VANDRIEL,* FRANZ TRAUB, AND MICHAEL K.SHOWE............. 220-223

Adsorption, Capping, and Release of a Complex Bacteriophage byMycoplasma Cells. KLAUS HABERER, JACK MANILOFF, * ANDDAVID GERLING ........................................... 264-270

CONTENTS

Volume 36 Contents for November 1980 Number2Animal Viruses

Characterization of a Unique Defective Type C Virus Associatedwith a Moloney Leukemia Virus-Induced Splenic T-Cell Lym-phoma Cell Line. IVAN HoRAK, JOHN C. LEE, Luis ENJUANES,AND JAMES N. IHLE* ............. ........................ 299-308

Separation of Cyanogen Bromide-Cleaved Peptides of the VesicularStomatitis Virus Glycoprotein and Analysis of Their Carbohy-drate Content. LAURA KINGSFORD, SUZANNE U. EMERSON, *AND J. MICHAEL KELLEY .......... ....................... 309-316

Identification of the Avian Myeloblastosis Virus Genome. I. Identi-fication of Restriction Endonuclease Fragments Associated withAcute Myeloblastic Leukemia. L. M. SOUZA AND M. A.BALUDA* ................................................ 317-324

Identification of the Avian Myeloblastosis Virus Genome. II. Restric-tion Endonuclease Analysis of DNA from A Proviral Recombi-nants and Leukemic Myeloblast Clones. L. M. SOUZA, M. J.BRISKIN, R. L. HELIYARD, AND M. A. BALUDA* ..... ......... 325-336

Unique Species of mRNA from Adenovirus Type 7 Early Region 1in Cells Transformed by Adenovirus Type 7 DNA Fragment.KoUICHI YOSHIDA AND KEI FUJINAGA* ..................... 337-352

Intracellular Forms of Simian Virus 40 Nucleoprotein Complexes.III. Study of Histone Modifications. M. COCA-PRADOS, G. Vi-DALI, AND M.-T. Hsu* .................................... 353.-360

Herpes Simplex Virus Thymidine Kinase Transcripts Are Absentfrom Both Nucleus and Cytoplasm During Infection in thePresence of Cycloheximide. WAI-CHoI LEUNG,* KENNETH Di-MOCK, JAMES R. SMILEY, AND SILVIA BACCHETrI.. 361-365

Abelson Murine Leukemia Virus Transformation-Defective Mutantswith Impaired P120-Associated Protein Kinase Activity. FREDH. REYNOLDS, JR., WIM J. M. VAN DE VEN, AND JOHN R.STEPHENSON* .. ................................. ... . 374-386

Heterogeneity of the 3' End of Minus-Strand RNA in the PoliovirusReplicative Form. OLIVER C. RICHARDS* AND ELLIE EH-RENFELD....... 387-394

Cloning of Human Papilloma Virus Genomic DNAs and Analysis ofHomologous Polynucleotide Sequences. CAROLE A. HErL-MAN,* MING-FAN LAw, MARK A. ISRAEL, AND PETER M.HOWLEY...... 395-407

Dual Evolutionary Origin for the Rat Genetic Sequences of HarveyMurine Sarcoma Virus. RONALD W. ELUS,* DEBORAH DEFEo,JEAN M. MARYAK, HowARD A. YOUNG, THOMAS Y. SHIH,ESTHER H. CHANG, DOUGLAS R. LOWY, AND EDWARD M.SCOLNICK ............................................ 408-420

Factors Which Disorganize Microtubules of Microfilaments Increasethe Frequency of Cell Transformation by Polyoma Virus.ROLAND SEIF..................................... 421-428

Synthesis and Processing of Glycoproteins gD and gC of HerpesSimplex Virus Type 1. GARY H. COHEN,* DEBORAH LONG, ANDROSELYN J. EISENBERG ................. ............. 429-439

Coronavirus Multiplication Strategy. II. Mapping the Avian Infec-tious Bronchitis Virus Intracellular RNA Species to the Ge-nome. DAVID F. STERN* AND S. IAN T. KENNEDY .......... 440-449

CONTENTS

Avian Oncovirus Mutant (SE21Q1b) Deficient in Genomic RNA:Characterization of a Deletion in the Provirus. PETER R.SHANK* AND MAXINE LINIAL .............................. 450-456

Mechanism of Inhibition ofHerpes Simplex Virus and Vaccinia VirusDNA Polymerases by Aphidicolin, a Highly Specific Inhibitor ofDNA Replication in Eucaryotes. GUIDO PEDRALI-NOY ANDSILVIO SPADARI*.457-464

Virion Nucleic Acid of Ebola Virus. RUSSELL L. REGNERY,* KARLM. JOHNSON, AND MICHAEL P. KILEY.465-469

Interaction of Influenza M Protein with Viral Lipid and Phosphati-dylcholine Vesicles. ANASTASIA GREGORIADES.470-479

Arrangement of the Genome of the Human Papovavirus RFVirus. ALAN PATER,* MARY M. PATER, AND GIAMPIERO DIMAYORCA.480-487

Identification and Initial Characterization of a New Low-Molecular-Weight Virus-Encoded T Antigen in a Line of Simian Virus 40-Transformed Cells. GREGORY J. SPANGLER, JAMES D. GRIF-FIN, HARVEY RUBIN, AND DAVID M. LIVINGSTON*.488-498

Close Similarity Between Endogenous Ecotropic Virus of Mus mus-culus molossinus and AKR Virus. SISIR K. CHATTOPADHYAY, *MARILYN R. LANDER, AND WALLACE P. ROWE.499-505

Epstein-Barr Virus RNA. V. Viral RNA in a Restringently Infected,Growth-Transformed Cell Line. WALTER KING, ANN L.THOMAS-POWELL, NANCY RAAB-TRAUB, MARY HAWKE, ANDELLIOTT KIEFF*.506-518

Characterization of Tau Antigens Isolated from Uninfected andSimian Virus 40-Infected Monkey Cells and Papovavirus-Trans-formed Cels. DANIEL T. SIMMONS.519-525

BALB/c Myeloma Retroviruses: Peptide Mapping and Immunolog-ical Analysis of the ppl2 Structural Protein. DALE R. SPRIGGSAND ROBERT G. KRUEGER ................................ 533-540

BALB/c Myeloma Retroviruses Have Mink Cell Focus-InducingActivity. DALE R. SPRIGGS, MARY A. DIEBOLD, AND ROBERTG. KRUEGER*.541-546

Abelson Murine Leukemia Virus-Induced Tumors Elicit AntibodiesAgainst a Host Cell Protein, P50. VARDA ROTTER, OWEN N.WITTE, ROBERT COFFMAN, AND DAVID BALTIMORE*.547-555

Small Reovirus-Specific Particle with Polycytidylate-DependentRNA Polymerase Activity. PETER J. GOMATOS,* NICHOLAS M.STAMATOS, AND NURUL H. SARKAR.556-565

A Cloned Polyoma DNA Fragment Representing the 5' Half of theEarly Gene Region Is Oncogenic. KAMAL CHOWDHURY,* SU-SAN E. LIGHT, CLAUDE F. GARON, YOSHIAKI ITO, AND MARK A.ISRAEL.566-574

Molecular Cloning of the Avian Erythroblastosis Virus Genome andRecovery of Oncogenic Virus by Transfection of ChickenCells. BJORN VENNSTROM,* LOIS FANSHIER, CARLO MOSCO-VICI, AND J. MICHAEL BISHOP.575-585

Incorporation of Influenza Virus M-Protein into Liposomes. D. J.BUCHER,* I. G. KHARITONENKOV, J. A. ZAKOMIRDIN, V. V.GRIGORIEV, S. M. KLIMENKO, AND J. F. DAVIS.586-590

Generation of Nondefective Rous Sarcoma Virus by AsymmetricRecombination Between Deletion Mutants. G. S. MARTIN,*W.-H. LEE, AND P. H. DUESBERG .......................... 591-594

CONTENTS

Leakage of Nuclear Transcripts Late in Simian Virus 40-InfectedCV1 Cells: Quantitation of Spliced and Unspliced Late 19SRNAs. Luis P. VILLARREAL* AND SUSAN JOVANOVICH 595-600

Dinucleotide Sequences at the 5' Ends of Vaccinia Virus mRNA'sSynthesized In Vitro. JERRY M. KEITH, ALAN GERSHOWITZ,AND BERNARD Moss* ..................................... 601-605

Abrogation of Radiation Leukemia Virus-Induced Lymphomagenesisby Antisera to Thymotropic but Not to Ecotropic or Dual-Tropic Viruses. MARTIN HAAs* AND JAN JONGSTRA . 606-610

Construction of a Specific Amber Codon in the Simian Virus 40 T-Antigen Gene by Site-Directed Mutagenesis. DAN R. RAWLINSAND NICHOLAS MUZYCZA* ............................ 611-616

Phosphorylation of the Nonstructural Proteins Encoded by ThreeAvian Acute Leukemia Viruses and by Avian Fujinami SarcomaVirus. KLAUS BISTER, WEN-HwA LEE, AND PETER H.DUESBERG* ............................................... 617-621

Viruses Isolated from Cells Persistently Infected with VesicularStomatitis Virus Show Altered Interactions with Defective In-terfering Particles. FRANK M. HORODYSKI AND JOHN J.HOLLAND* ............................................... 627-631

Bacterial VirusesSuperinfection Exclusion by Heteroimmune Corynebacteriophages.

N. B. GROMAN* AND M. RABIN ....................... 526-532New Deletion Mutant of Bacteriophage T5. MARC RHOADES,*

JOANNA SCHWARTZ, AND JEFFREY M. WAHL ..... ........... 622-626

Plant VirusesExpression of Bottom Component RNA of Cowpea Mosaic Virus in

Cowpea Protoplasts. GEERTJE REZELMAN, ROB GOLDBACH,*AND ALBERT VAN KAMMEN ......... ...................... 366-373

Volume 36 Contents for December 1980 Number 3

Animal VirusesMappings of Adenovirus 12 mRNA's Transcribed from the Trans-

forming Region. YUKIHARU SAWADA AND KEI FUJINAGA* ... 639-651Viral Hemorrhagic Septicemia of Rainbow Trout: Selection of a

Thermoresistant Virus Variant and Comparison of PolypeptideSynthesis with the Wild-Type Virus Strain. P. DE KINKELIN,*MONIQUE BEARZOrrI-LE BERRE, AND JACQUELINE BERNARD 652-658

Comparison of the Nucleotide Sequence at the 5' End of RNAs fromNine Aphthoviruses, Including Representatives of the SevenSerotypes. TIMOTHY J. R. HARRIS.659-664

gA and gB Glycoproteins of Herpes Simplex Virus Type 1: TwoForms of a Single Polypeptide. R. EBERLE AND RICHARD J.COURTNEY* .............................................. 665-675

Avian Erythroblastosis Virus Produces Two mRNA's. STEVEN M.ANDERSON,* WILLIAM S. HAYWARD, BENJAMIN G. NEEL, ANDHIDESABURO HANAFUSA .......... ........................ 676-683

Integration, Expression, and Infectivity of Exogenously AcquiredProviruses of Rous-Associated Virus-0. NANCY A. JENKINSAND GEOFFREY M. COOPER* .............................. 684-691

CONTENTS

Reverse Transcriptase as the Major Determinant for Selective Pack-aging of tRNA's into Avian Sarcoma Virus Particles. GORDONG. PETERS* AND JAMES Hu ......... ...................... 692-700

Simian Virus 40-Associated Small RNA: Mapping on the SimianVirus 40 Genome and Characterization of Its Synthesis. JAMESC. ALWINE* AND GEORGE KHOURY ....... .................. 701-708

Physical Map of Infectious Baboon Type C Viral DNA and Sites ofIntegration in Infected Cells. NARAYANA BATTULA* ANDGEORGE J. TODARO ............. .......................... 709-718

Translational Control of Protein Synthesis After Infection by Vesic-ular Stomatitis Virus. HARVEY F. LODISH* AND MARYPORTER ................................................. 719-733

Characterization of Endogenous and Exogenous Mouse MammaryTumor Virus Proviral DNA with Site-Specific MolecularClones. BERND GRONER,* ELENA BUETrI, HEIDI DIGGEL-MANN, AND NANCY E. HYNES ........ ...................... 734-745

Properties of Cells Carrying the Herpes Simplex Virus Type 2 Thy-midine Kinase Gene: Mechanisms of Reversion to a ThymidineKinase-Negative Phenotype. K. F. BASTOW, G. DARBY, P.WILDY, AND A. C. MINSON* ......... ...................... 746-755

RNA Synthesis of Vesicular Stomatitis Virus. X. Transcription andReplication by Defective Interfering Particles. DONALD D.RAO AND ALICE S. HUANG* ......... ...................... 756-765

Abelson Murine Leukemia Virus Mutants Deficient in Kinase Activ-ity and Lymphoid Cell Transformation. NAOMI E. ROSEN-BERG,* DANIEL R. CLARK, AND OWEN N. WITrE ..... ....... 766-774

Intracellular Distribution of Sindbis Virus Membrane Proteins inBHK-21 Cells Infected with Wild-Type Virus and Maturation-Defective Mutants. CHRISTINE ERWIN AND DENNIS T.BROWN*.... 775-786

Structural Relationships Between the Surface Antigens of GroundSquirrel Hepatitis Virus and Human Hepatitis B Virus.WOLFRAM H. GERLICH, MARK A. FEITELSON, PATRICIA L. MAR-ION, AND WILLIAM S. ROBINSON* ....... ................... 787-795

Replicative RNA Synthesis and Nucleocapsid Assembly in VesicularStomatitis Virus-Infected Permeable CelLs. JON H. CONDRA*AND ROBERT A. LAZZARINI ......... ....................... 796-804

Association of pp6Osrc and src Protein Kinase Activity with thePlasma Membrane of Nonpermissive and Pernissive Avian Sar-coma Virus-Infected Cells. R. A. KJRZYZEK, R. L. MITCHELL,A. F. LAU, AND A. J. FARAS* ........ ...................... 805-815

Analysis of Herpes Simplex Virus Nucleoprotein Complexes Ex-tracted from Infected Cells. PIER F. PIGNATTI* AND ENZOCASSAI .................................................. 816-828

Virus of Pekin Ducks with Structural and Biological Relatedness toHuman Hepatitis B Virus. WILLIAM S. MASON,* GEETA SEAL,AND JESSE SUMMERS ........... .......................... 829-836

Nucleic Acids of Respiratory Syncytial Virus. DENNIS M. LAM-BERT,* MARCEL W. PONS, GUSTAVE N. MBUY, AND KAROLINEDORSCH-HASLER ................ ......................... 837-846

Defective Interfering Influenza Viruses and Host CelLs: Establish-ment and Maintenance of Persistent Influenza Virus Infectionin MDBK and HeLa Cells. BARUN K. DE AND DEBI P.NAYAK...*.............................................. 847-859

CONTENTS

Regulation of Integrated Adenovirus Sequences During AdenovirusInfection of Transformed Cells. DAVID J. SPECTOR, DONALDN. HALBERT, AND HESCHEL J. RASKAS* ........... ......... 860-871

Structure of and Alterations to Defective Murine Sarcoma VirusParticles Lacking Envelope Proteins and Core PolyproteinCleavage. ANTHONY DEMSEY,* FULMER COLLINS, AND DOUG-LAS KAWRKA.......... 872-877

Cloned Human Polyomavirus JC DNA Can Transform Human Am-nion Cells. PETER M. HOWLEY,* FRANCOISE RENTIER-DEL-RUE, CAROLE A. HEILMAN, MING-FAN LAW, KAMAL CHOW-DHURY, MARK A. ISRAEL, AND KENNETH K. TAKEMOTO ...... 878-882

Envelope Assembly Mutant of Rous Sarcoma Virus. KATHELYN S.-STEIMER* AND DAVID BOETTIGER ......................... 883-888

Partial Phosphorylation In Vivo of the Avian Retrovirus pp32DNA Endonuclease. RON D. SCHIFF AND DUANE P.GRANDGENETT* ................... .... 889-893

Subunit Structure of the Reovirus Spike. S. J. RALPH, J. D.HARVEY, AND A. R. BELLAMY ............................. 894-896

Bacternil VirusesEvidence for Heterogeneity in Populations of T5 Bacteriophage. II.

Some Particles Are Unable to Inject Their Second-Step-Trans-fer DNA. CHRISTIAN HULEN,* BERNARD LABEDAN, AND JEANLEGAULT-DEMARE.633-638

INDEX TO DATE OF ISSUE

Date of Issue

9 October 198030 October 198020 November 1980

Month

OctoberNovemberDecember

Pages

1-297299-631633-896