JouRNAL oF DRuG RESEARCH -...

JouRNAL oF DRuG RESEARCH Vol. 1, No. 1 IN AyuRvEDIC SCIENCES July- September 2015

CoNTENTS

S.No. Particulars Page No.

1. Vijay¡ (Cannabis sativa L.) and its Therapeutic 1-12 Importance in Ayurveda: A Review Rabinarayan Acharya, Kartar Singh Dhiman, Anagha Ranade, Raghawendra Naik, Shashikant Prajapati and Sanjeev Kumar Lale

2. Crude drugs identification: A case study (Part 2) 13-31 Kumar Avinash Bharati and H. B. Singh

3. Traditional Folk Medicinal Practices Among the Indigenous 32-46 People of Dhalai District of Tripura Jyotirmay Choudhury, Devanjal Bora, D. Baruah, T. Borah and B. K. Bharali

4. Pharmacognostic and Preliminary Phytochemical 47-60 Studies on the Flowers of Kovidara: Bauhinia purpurea L. T. R. Shantha, M. Prathapa Reddy, v. Rama Rao, vandana bharthi, R. Kishore Kumar and G.venkateswarlu

5. Plants of Holy Bible and its Usage in Ayurveda 61-74 Rosy R., P. Jeneka Devi, Suneel Babu B., Prerna, Ashish K.Tripathi, Chinmay Rath and G. v. R. Joseph

6. Medico-Ethno-Botanical Survey of Satna Forest Division, 75-101 Madhya Pradesh, INDIA Sugriv Kumar Gaur & Sanjeev Kumar Lale

7. Infomation/Guidelines for the Authors/Contributors for 102-105 JDRAS

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Vijay¡ (Cannabis Sativa L.) and its Therapeutic ......

VijayË (Cannabis sativa L.) and its therapeutic importance in ayurveda: a review

Rabinarayan Acharya1, Kartar Singh Dhiman2, Anagha Ranade3, Raghawendra Naik4, Shashikant Prajapati5 and Sanjeev Kumar Lale6

aBstract

Vijay¡, commonly known as Bha´ga in Hindi and cannabis in English, a drug of herbal origin, has been used by the Ayurvedic physicians, for the management of various disease conditions. Due to its narcotic and addiction effect, this plant has been restricted from medicinal uses. In the recent past this plant has attracted many researchers for its medicinal values i.e. antiemetic against chemotherapy induced vomiting, glaucoma, insomnia, anxiety, depression, epilepsy and pain etc. The paper is an attempt to collect and explore the information related to Vijay¡ from various available Ayurvedic Gra¸thas (Aborginal Texts/Compendium) popularly known as SaÆhit¡s, SÆgraha Graha, Chikits¡ Gra¸tha, Rasa Gra¸thasa and Nigha¸¶us. Ayurveda advocates the judicious use of Vijay¡ after proper áodhana (Processing). It was observed that the processed drug is used as a single or ingredient of 191 formulations which is effective in various disease conditions viz. G¤han¢ (Malabsorption syndrome), Jvara (Fever), Atis¡ra (Diarrhoea), Agn¢m¡ndya (Diminished digestive fire), Aj¢rna (Dyspepsia), Prameha (Urinary disorders), Sa¸g¤han¢ (Irritable bowel syndrome), áiroroga (Disease of head), K¡sa (Cough), KuÀ¶ha (Diseases of skin), P¡n·u (Anemia), Jvar¡t¢s¡ra (Diarrhoea with fever), áotha (Inflammation), á£la (Colic), Abhiny¡sa Jvara (Meningitis), Hikk¡ áv¡sa (Hiccup, Dyspnoea /Asthma), Medoroga (Lipid disorders), á¢tapitta (Urticaria) etc.

Key words Bh¡´ga, Cannabis sativa, Ayurveda, UpaviÀa

Introduction:

Vedas (6000BC), SaÆhit¡s (1500BC-600AD), Nigha¸tus and SaÆgraha Gra¸th¡s (800AD - 1900AD) are the source of information of the drugs obtained from natural origin in Ayurveda.1 Since long, Vijay¡, a drug of herbal origin, has been used by the Ayurvedic physicians, for the management of different disease conditions. The botanical source of the plant is Cannabis sativa L. of the family Cannabinaceae. It is an annual, erect, dioecious herb, one to two meter high, available almost throughout the year; practically naturalized in the sub Himalayan tracts in India and abundantly found in the waste lands from Punjab east wards to Bengal and extending south wards.2

Texts related to Ayurveda in general and medicinal plants in particular systematically recorded the part used, pharmacological properties, áodhana (processing) procedures, actions, indications and contraindications of the plant drug. Its utilization as an ingredient of compound formulations was recorded in various SaÆg¤ha Gra¸th¡s (Compendia of Ayurveda). Considering its therapeutic importance, claimed in various classical texts of Ayurveda and other traditional

J.D.R.A.S. Vol. I, No. 1, (2015) pp. 1-12

1, 3, 4, 5 - Deptt. of Dravyaguna, IPGT&RA, Gujarat Ayurved University, Jamnagar, Gujarat, India, 361 008., 2 & 6 - Central Council for Research in Ayurvedic Sciences, Janakpuri, New Delhi-110058

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Rabinarayan Acharya et. al.

system of medicines, a review of its uses in various diseases with its chemical constituents is presented here, some of the earlier scientists reported the therapeutic aspect of cannabis and cannabinoids 3, the use of cannabis in cancer chemotherapy. The cannabis is also explored by Ethna Russo5 as the ancient lore of cannabis in India and the use of cannabis in medieval period was reported by Chaturvedi et al.6 and the standardization parameters of the drug along with its ethno-medicinal uses, pharmacological, pharmacognostic and chemical studies has also been established.7,8

After extensive review of literature of the plant it was found that many evidences reported in classical texts of Ayurveda, on Vijay¡, has neither been explored nor presented in a systematic manner. This treasure, if explored, can serve as a lead to researcher for the study of this drug extensively. Therefore an attempt has been made to systematic compilation and exploration of the synonyms, properties, actions and various formulations with their Adhik¡ra (prime indication) of Vijay¡ with the help of various SaÆhit¡s (classical texts), Nigha¸¶us (lexicons), Rasa G¤nth¡s (Compendia related to Rasa á¡stras), SaÆg¤ha and Cikits¡ Gra¸tha (compendia of Ayurveda). Results and Discussion: There is no direct reference about the use of the plant Vijay¡, as medicine in the Veda and SaÆhit¡ Gra¸thas of Ayurveda. However, the name Soma and Vijay¡ provided a basis for debate for many authors regarding the existence of Vijay¡ in vedic and SaÆhit¡ period5,9,10. The medicinal uses of Vijay¡ can be traced in the Ayurvedic texts written during the medieval period. In Ayurveda, different traditionally used names, known as Pary¡ya (synonyms) have been attributed to a single plant to describe its morphological description habitat, habit and pharmacological characters.11

there are about 40 synonyms attribute to Vijay¡ to describe its

morphological and pharmacological characters are available in various classical texts of Ayurveda written during different time. On the basis of reported synonyms it is presumed that, flowers are dioecious and blooms in bunches (SaÆvida ma¸jar¢). Most of the synonyms suggest its action on CNS especially indulged in developing delirium, state of euphoria, hallucinations, etc. Many synonyms are of mythological origin indicating its frequent uses and close relation with the society during the ancient period (Table: 1).

Table 1: Synonyms attributed to Vijay¡ by different classical texts of Ayurveda 12-22

pharmacognostical characters

Flower M¡tul¡ni Male and female flowers are separate.

SaÆvida manjar¢ Flower blooms in bunches i.e have inflorescences

synonyms based on pharmacological actions

Central nervous system

Bahuv¡dini, G¡nja Delirium

Ananda, Chhidalhada, HarÀani, M¡din¢, Mohin¢, Ranjik¡,

State of euphoria, hallucinations

Tandr¡k¤ta Drowsiness

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Psychological Manonmana Accomplishes objects of mind

Gastrointestinal disorders

Jay¡ Cures diarrhea/ Control CNS

Other diseases Bh¡¸ga Destroys kaphaja roga

synonyms based on mythological origin

Lord áiva áivam°li Favorite to lord Shiva

Lord Indra áarkr¡sana The worthy food of lord Indra

Blessings Siddhi, Siddhid¡, Trailokya Vijay¡, Bh¡ngi, Vijay¡

That which gives special blessings and is victorious in all three worlds

Related to time Divy¡, K¡laghn¢ PaÀupa¿avin¡¿in¢

Supernatural Overcomes death Liberates creatures from earthly bonds

othersInsecticidal action

Matkunak¡ri Destroying bugs

Classification:

Vijay¡ has been described under UpaviÀa Varga (Group of sub-poisonous plants) by certain texts related to Rasa á¡stra. Its categorization under UpaviÀa Varga (sub-poisonous) may be due to its reported action on CNS, in over use. However, Nigha¸¶us (Lexicons) of Ayurveda details Vijay¡ under different plant groups by keeping the drug under various Vargas like Guduchy¡di, Karvir¡di, Abhay¡di, K¿upa, AuÀadhi and áatapuÀp¡di (Table-2)

Pharmacological properties:

Vijay¡ is having Tik¶a Rasa; UÀ¸a V¢rya; has Laghu T¢kÀ¸a Gun¡s and Ka¶u Vip¡ka. It pacifies Kapha and V¡ta DoÀ¡s, increases Pitta DoÀ¡s and has D¢pana, P¡cana, Ruchya, Madak¡ri and Vyav¡y¢ action. It has also been attributed with G¤¡h¢, Medhya and Ras¡yana action.(Table:2) Rasatara¸agin¢48, have attributed more than 29 pharmacological properties/ indications to Vijay¡ like Nidr¡pradayini /Swapna K¡raka (Induce sleep), Sant¡na k¡raka (improves reproductive capacity), Ëm¡¿aya Balaprada (Provides strengths to gastrointestinal tract), M£trala (Diuretic), Pral¡pana¿¡ka (Relieves delirium) and indicated in disease conditions like Prameha (Urinary disorders), Dhanusthambha (Titanic condition), Ëntra á£la (Gastric pain), V¤kka á£la (Renal Colic), áoÀa (Emaciation), á£la (Colic), Ajir¸a (Dyspepsia), Unm¡da (Insanity), Rakta sanyukta m£trata (Hematuria), Ar¿a (Piles), Jvara (Fever), Vra¸a (Wound), N¡d¢ daurbalya ( Nervine debility), Rajah¿£la (Dysmenorrhea), YakÀm¡ (Tuberculosis), K¡sa (Cough), Ëm¡¿aya¿£la (Intestinal pain), Tamaka áv¡sa (Asthma), Garbha G¤ha, Rakta Pradara (Menorrhagia), Ardh¡vabhedaka (Migraine).

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Table 2: Pharmacological properties attributed to Vijay¡ in different Nigha¸¶us:

Nigha¸¶u/Rasa gra¸tha

Rasa Guna V¢rya Vip¡ka Karma Doshaghnata

Dhanvantari Nigha¸¶u12

(Guduchy¡di Varga)

Tik¶a Laghu, T¢kÀ¸a

UÀ¸a Gr¡h¢, P¡cana Kaphahara, Pittala

áodhala Nigha¸¶u13

(Lakshman¡di Varga)

Laghu UÀ¸a D¢pana, Gr¡h¢, P¡cana,

Kaphav¡tahara, Pittala

Sh¡rangadhara Samhita14

Vyav¡yi

Madanapala Nigha¸¶u15

(Har®taky¡di Varga)


UÀ¸a Gr¡h¢, D¢pana

Kaphahara, Pittala

Kaiyadeva Nigha¸¶u16

(Aushadhi Varga)


UÀ¸a Gr¡h¢, D¢pana, Ruchya, Madak¡ri

Kaphav¡tahara, Pittala

Bh¡vaprak¡sha17

(Har¢taky¡di Varga)Tik¶a Laghu,

T¢kÀ¸aUÀ¸a Gr¡h¢, P¡cana Kaphahara,

Pittala

SiddhabhaiÀaja Manimala18

Laghu Kaphahara

á¡ligr¡ma Nigha¸¶u19

(Ashtavarga)T¢kÀ¸a, Laghu

Medhya, Ras¡yana, D¢panaGr¡h¢, P¡cana

Kaphav¡tahara

P¤ya Nigha¸¶u20

(áatapuÀp¡di Varga)Tik¶a UÀ¸a Ka¶u Pittala

áodhana (Purification/ Processing):

áodhana23 is one of the unique concepts of Ayurveda where the plants possible toxic effects are passed through specific recommended process with certain Bh¡van¡ Dravya (Media) before clinical administration to reduce the toxic effect and make them therapeutically effective, in prescribed doÀa.24 Classical texts of Ayurveda, categories Vijay¡ under UpaviÀa Varga (Sub- poisonous group) and advocated certain áodhana (Purificatory / Processing) procedures before its internal administration. There are four different methods being recommended by various authors for áodhana of Vijay¡. Method I: The leaves of cannabis are to be tied in a cloth and washed in water. This process has to be continued until the greenish colour stops oozing from the leaves. After this, the leaves are dried under the shade and use for the therapeutic purpose1, 2

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Method II: The dry leaves are procured and washed in water and pressed. They are then subjected to drying under direct sun light and later on roasted with Gogh¤ta (Cow's clarified butter). These roasted leaves are to be used for therapeutic purpose3,4

Method III: In another method the Cannabis leaves are to be subjected for Svedana (Fomentation) in Godugdha (Cow’s milk) for approximately 3 hours and then washed with water. After getting it dried, it is being roasted in Goghrita.5

Method IV: The cannabis leaves are to be fomented in the decoction of Babb£la Tvak (Bark of Acacia arabica Willd.: Mimosaceae) for 12 minute with moderate heat and then subjected to drying under direct sun light. Further, they are triturated with Godugdha (Cow’s milk), dried and used for therapeutic purpose.3,4,5,6,7

Formulations: Uses of Vijay¡, as a drug, were gradually increased, during medieval period. SaÆgraha Gra¸thas (Different pharmacopoeia) of Ayurveda reports about 191 formulations of 13 different dosage form having Vijay¡ as an ingredient. It is used, both internally (187 formulations) as well as externally (four formulations), in various 13 dosage forms. Among these 111 Rasa AuÀadhi (Herbo- mineral-metallic preparations), 30 Gu¶ik¡ (Tablet), 17 C£r¸a (Powder); 09 Avaleha (Confectionaries); 4 Ësva (self-generated alcoholic preparations) and oil preparations; 03 Kv¡tha (Decoction) and Gh¤ta preparations and one each in AriÀta (Alcoholic preparations), Modaka (Bolus) preparation, Sattva (Essence), Lauha (Iron base preparation) (Table 3)

Table 3: Vijay¡ containing formulations, arranged in alphabetic order.

Ayurvedic text No. Rogadhik¡ra Dosage forms

Ayurved Prak¡¿a32 1 Ëdhm¡na Rasa

BhaiÀajya Ratn¡val¢26

32 Grahan¢, áotha, At¢s¡ra, Jvar¡tis¡ra, Prameha, áiroroga, Ras¡yana, KuÀ¶ha, V¡tarakta, K¡sa

Taila, Gu¶ik¡, Gh¤ta, C£r¸a, Rasa

Bh¡rata BhaiÀajya Ratn¡kar33

23 Jvara, Ras¡yana, KaÀt¡rtava, Ëmv¡ta, Ras¡yana, At¢s¡ra, Unmada, Grahan¢, KÀ¡ya, Sa¸grahan¢, Svarabheda

Rasa, Avaleha, C£r¸a, Gutik¡, Gh¤ta

Bh¡vprak¡¿a34 4 Atis¡ra, N¡s¡roga, Jvara Avaleha, Putap¡ka, Rasa

B¤had NighantuRatn¡kar35

21 Grahan¢, Atis¡ra, B¡laroga, Jvara, Agnim¡ndya-Aj¢r¸a, Sa¸grahan¢, á¢tapitta, á£la

Avaleha, C£r¸a, Gu¶ik¡, Rasa

B¤had YogaTara¸gin¢36

15 Grahan¢, KÀ¡ya, Ëmav¡ta, Agnim¡ndya, Jvara Atis¡ra Udar Prameha, Sannip¡ta Jvara

C£r¸a, Rasa, Ësava, Gu¶ik¡, Avaleha

Gada Nigraha37 6 Jvara, Gulma, N¡s¡roga, Udara Ësava, C£r¸a, Kv¡tha, Putap¡ka

Nigha¸¶u Ratn¡kara38

1 Atis¡ra Avaleha

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Rasa Cint¡man¢39 5 A¿mar¢, K¡sa, Sann¢pata Jvara, KuÀ¶ha

Gu¶ik¡, Rasa

Rasa Kaumudi40 1 Grahan¢ Rasa

Rasa Mangala41 1 Jvara Rasa

Rasa Prak¡¿aSudh¡kara42

6 Sa¸grahan¢, Prameha, Grahan¢, R¡jayakÀm¡

Rasa, Gut¢ka

Rasaraja Sundara43 29 Sa¸grahan¢, Jvara, Medoroga, á£la, Grahan¢, Agnim¡ndya-Aj¢r¸a, Atis¡ra, Hikk¡ - áv¡sa, Prameha, V¡tavy¡dh¢, Ëmav¡ta, Ar¿a, K¡sa, áiroroga, R¡jayakÀm¡, Jvar¡tis¡ra, Grahan¢, KuÀ¶ha

Gu¶ik¡, Rasa, C£r¸a

Rasa RatnaSamucchaya44

12 V¡jikarana, Grahan¢, á£la, Ar¿a, Agnim¡ndya, V¡tavy¡dh¢, Jvara, Ras¡yana, Sa¸grahan¢

KÀara, Rasa

Rasa Ratn¡kara45 18 Ras¡yana, Grahan¢, , Sa¸grahan¢, V¡jikarana, Agnim¡ndya, Atis¡ra, Jvara, Medoroga, á£la, Udara, Ëmav¡ta, K¡sa, áiroroga, áotha

Avaleha, Ch£rna, Gu¶ik¡, Rasa, Taila

Rasa S¡gara46 1 KÀaya Avaleha

Rasa Sanket K¡lik¡47

2 Grahan¢, V¡jikaran Gu¶ik¡, Rasa

Rasa Tarangin¢ 48 6 V¡j¢karana, áukrastambhaka, V¤kka roga

Rasa, Gu¶ik¡ Modaka.

RasacandaÆ¿u49 20 Grahani, Jvara, K¡sa, Ras¡yana, á¢tapitta, Sa¸grahan¢, Atis¡ra, Medoroga, á£la, R¡jayakÀm¡, Agnim¡ndya, áiroroga, Prameha

Rasa, C£r¸a, Gu¶ik¡

Rasak¡madhenu50 30 Jvara, Apasm¡ra, P¡¸·u, Agnim¡ndya, Sa¸grahan¢, Atis¡ra, Gulma

Rasa, Parpat¢, Gu¶ik¡, C£r¸a, Lepa

Rasamanjar¢51 4 Apasm¡ra, Sa¸grahan¢, V¡j¢karana

Rasa, C£r¸a

Ras¡m¤ta52 1 Aj¢r¸a Rasa

Ras¡yna S¡ra53 3 Prameha, KuÀ¶ha Rasa, Lauha

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Rasayoga Sa¸graha54

46 R¡jayakÀm¡, P¡¸·u, Sthaulya, V¡tavyadh¢, áiroroga, K¡sa, Grahan¢, Jvara, Jvar¡tis¡ra, Agnim¡ndya, Jvar¡tis¡ra, Medoroga, Urustambha, á£la,, Agnim¡ndya-Aj¢r¸a, KuÀ¶ha,

Rasa, Gu¶ik¡, Modaka, C£r¸a

Rasendra Cint¡man¢55

6 Jvara, Medoroga, Vidradh¢, Urustambh

Rasa

Rasendra S¡ra Sa¸graha56

33 áiroroga, Grahan¢, Jvara, Agnim¡ndya, Jvar¡tis¡ra, K¡sa, á£la, Medoroga, Agnim¡ndya-Aj¢r¸a, KuÀ¶ha, Sthaulya, V¡tavyadh¢, Urustambha, Jvar¡tis¡ra, Abhiny¡sa jvara, ViÀamajvara

Rasa, Gu¶ik¡, Lauha

Sahasra Yoga 57 3 Prameha, At¢s¡ra, Ëmavik¡ra Ësava, Gu¶ik¡

á¡ra¸gdhar Sahit¡14

2 R¡jayakÀm¡, Sa¸grahan¢ Rasa

Vangasena58 3 Ras¡yana, Udara, N¡s¡roga Avaleha, Rasa

Vridam¡dhava59 1 Prameha Kv¡tha

Yoga Tarangin¢60 2 V¡jikarana, Grahan¢ Avaleha, C£r¸a

Yogachint¡man¢61 3 R¡jayakÀm¡, V¡jikarana Rasa, Gu¶ik¡, Avaleha

Yogaratn¡kara62 17 Agnim¡ndya, At¢s¡ra, Grahan¢, Ras¡yana, KuÀ¶ha, Jvara, K¡sa, Medoroga, Urustambha

Ësava, Avaleha, C£r¸a, Gu¶ik¡, Kv¡tha, Rasa

Indications:

Formulations containing Vijay¡ are effective in more than 29 disease conditions like Grahan¢ (Malabsorption syndrome), Jvara (Fever), Atis¡ra (Diarrhoea), Agn¢m¡ndya- Aj¢r¸a (Dyspepsia) Prameha (Urinary disorders), Sa¸grahan¢ (Irritable bowel syndrome), áiroroga (Disease of head), K¡sa (Cough), KuÀ¶ha (Diseases of skin), P¡¸·u (Anemia) Jvar¡tis¡ra (Diarrhoea with fever) áotha (Inflammation), á£la (Colic), Abhiny¡sa Jvara (Meningitis), Hikk¡ áv¡sa (Hiccup, Dyspnoea / Asthma), Medoroga (Obesity) and á¢tapitta (Urticaria) etc. (Table: 3)

Highest number of formulations was found to be indicated in Grahan¢(30), followed by Jvara (17), Atis¡ra (9) and Agn¢m¡ndya/Aj¢r¸a (7), Prameha (06) and SaÆgraha´i. (Table 3).

The main part use of Vijay¡, for medicinal purpose, is its leaf in áodhita (Processed) form in a dose of 125-250 mg.

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Table 4: Indications of formulation having Vijay¡ as an ingredient in different classical texts of Ayurveda

Sr No Disease Probable English

Equivalent term (AFI)63Number of

formulations

1 Grahan¢ Malabsorption syndrome 30

2 Jvara Fever 17

3 At¢s¡ra Diarrhoea 9

4 Agn¢m¡ndya Diminished digestive fire 7

5 Prameha Urinary disorders 6

6 SaÆgrahan¢ Malabsorption syndrome 5

7 P¡¸·u Anemia 4

8 áiroroga Disease of head 4

9 K¡sa Cough 3

10 KuÀ¶ha Dermatopathies 3

11 R¡jayakÀm¡ Tuberculosis 3

12 Sannip¡ta Roga Disease due to vitiation of all Dosha 3

13 áotha Inflammation 3

14 Jvar¡tis¡ra Diarrhoea with fever 2

15 N¡s¡roga Disease of nose 2

16 á£la Colic 2

17 Udara Diseases of abdomen 2

18 Urustambha Stiffness in thigh muscles 2

19 V¡tavy¡dh¢ Diseases due to Vata dosha 2

20 Abhiny¡sa Jvara Meningitis 1

21 Ar¿a Haemorrhoids 1

22 A¿mar¢ Calculus 1

23 Hikk¡ áv¡sa Hiccup,Dyspnoea/Asthma 1

24 Medoroga Lipid disorders 1

25 á¢tapitta Urticaria 1

26 Svarabheda Hoarseness of voice 1

27 V¡tarakta Gout 1

28 Vidradhi Abscess 1

29 V¤kka Roga Disorders of Kidney 1

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Conclusion :

Vijay¡ is found throughout India and its description can be traced since ancient era. Its medicinal use has been highlighted since the medieval period. Vijay¡ should be administered internally after specific áodhana (processing) as recommended by classical texts of Ayurveda. Vijay¡ has been attributed with different pharmacological properties i.e Tik¶a Rasa; Laghu T¢kÀ¸a Guna, UÀ¸a V¢rya and Ka¶u Vip¡ka. It pacifies Kapha and V¡ta DoÀas, increases Pitta DoÀa and has D¢pana, P¡cana, Rocana, Madak¡r¢ and Vyav¡y¢ action. It has also been attributed to 29 pharmacological properties and actions, can be administered in more than 13 dosage form and useful to combat more than 29 disease conditions such as Grahan¢(Malabsorption syndrome), Jvara (Fever), Atis¡ra (Diarrhoea), Agnim¡ndya (Diminished digestive fire), Ajir¸a ( Dyspepsia) Prameha (Urinary disorders), SaÆgrahani (Malabsorption syndrome) etc. Vijay¡ fulfills the criteria of a good and effective drug, as recommended in the classical texts of Ayurveda. More intensive scientific study on various classically claimed disease conditions of Vijay¡ is the need of the time. references :1. Sharma PV. Ayurved ka Vaigyanik Itihas. Varanasi: Chaukhambha Orientalia; 2001.2. Anonymous. Ayurvedic pharmacopoeia of India Vol.1, Part I. Delhi. The Controller of

Publication; 1990.3. Philips R. Therapeutic aspects of cannabis and cannabinoids. British journal of

psychiatry.2001; 178: 107-115. 4. Ungerleider JT. Cannabis and cancer chemotherapy: a comparision of oral delta -9

THC and prochlorperazine. Therese Andrysiak, RN, Lynn Fairbank, James Goodnight, Gregory Saran, and Kay Jamison Cancer. 1982; 50: 636-645.

5. Russo E. Cannabis in India: ancient lore and modern medicine, Cannabinoids as therapeutics. Switzerland. Birkhauser verlag. 2005.

6. Chaturvedi GN, Twari SK and Rai NP. Medicinal use of opium and cannabis in medieval India. Indian journal of History of science. 1981; 16(1): 31-35.

7. Anonymous. Quality standards of Indian Medicinal plants, Vol. IV: New Delhi; Indian Council of Medical Research; 2006.

8. Anonymous. Reviews on Indian Medicinal plants, Vol.V: New Delhi; Indian Council of Medical Research; 2007.

9. Grierson GA. The hemp plant in Sanskrit and Hindi literature. Indian Antiquity. 1894; 260-262.

10. Dwarakanath C. Use of opium and cannabis in the traditional systems of medicine in Indian Bullition of Narcotics. 1965; 17: 15-19.

11. Acharya RN. Nomenclature of medicinal plants through classical technical term paryaya (synonyms) - A review. New Delhi: Sabdayana Commission for Scientific and Technical Terminology, Ministry of Human Resource Development, Department of Higher Education, Govt. of India. 2011; 121-126.

12. Sharma AP (2005). Dhanvantari nighantu Guduchyadi varga. , edited by Dr. Guruprasad Sharma . Chaukhambha orientalia, Varanasi; 39.

13. Vaidyacharya Shodhala: Shodhala Nighantu (Namasangraha and Gunasangraha). Lakshmanadi varga. Edited by Prof. Priya Vrat Sharma (1978). Oriental Institute, Baroda.;75.

14. Sharangdhara (2006). Sharangdhar Samhita. With commentaries Aadhamalla and Kasiramas Gudarth Dipika. edited by Pt.Parashuram Shastri Vidyasagar. Chaukhamnha Surbharati Prakashana,Varanasi.

15. Nripamadanpala (2009). Madanpala Nighantu. Abhayadi varga, Edited by Pandit Hariharprasad Tripathi , Chaukhamba Krishnadas Academy, Varanasi; 91.

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16. Acharya Kaiyadeva (2006). Kaiya deva Nighantu (Pathyapathya - Vibhidaka), Aushadhi varga, Edited and translated by Prof. Priyavata Sharma and Dr. Guru Prasad Sharma . Chaukhamba Orientalia, Varanasi; 648.

17. Shri Bhavamishra (2006). Bhavprakasha Nighantu. Haritakyadi varga, Commentary by Prof. K. C. Chunekar. Edited by Late Dr. G.S. Pandey Chaukhamba Bharati Academy, Varanasi; 141.

18. Kavi Shri Krishanaram Bhatt (2003). Siddhabhaishajmanimala with ‘Vaishwanara’ Hindi commentary. Edited by Shri R. Kalachara Bhatt, Chawkhambha Krishnadas Academy, Varanasi.

19. Shaligrama (2011): Shaligram nighantu. 1st ed., Khemraj Srikrishnadas Prakashan, Mumbai.

20. Sharma PV (2004). Priya nighantu. 1st ed. Chaukhamba Surabharati Prakashan, Varanasi.21. S. D. Kamat (2006). Saraswati nighantu. Karpuradi varga 19, 35. Chaukhambha Sanskrit

Pratisthan, Delhi.22. Shivadatta Mishra (1952). Shivakosha. edited by R. G. Harshe . Samarth Bharat Press,

Poona; 276, 469.23. Rabinarayan Acharya; Shodhana (2014): An Ayurvedic detoxification technique and its

impact on certain medicinal plants: conservation, cultivationad exploration of therapeutic potential of medicinal plants, Central Council of Research in Ayurvdic Scienses, department of Ayush, Govt of India.

24. Illanchezian R, Rosy J and Acharya R. Importance of media in Shodhana (purification/processing) of poisonous herbal drugs. Ancient science of life. 2010; 30(2): 27-30.

25. Acharya YT (1998). Rasamrutam. english translated by Dr. Damodar Joshi & Dr. G. Prabhakara Rao Chaukhambha Sanskrit Bhawan, Varanasi.

26. Vinod lal Sen (2005): Bhaishyajya ratnavali. edited by Gyanendra Pandey. Appendix C, Chaukhambha Sanskrit Series Office, Varanasi; 529.

27. Pranacharya Shree Sadanand Sharma (2009): Rasatarangini. Edited by Kashinath Shastri. Motilal Banarasidas, Delhi.

28. Vishwanath Dwivedi(1997): Rasendrasambhava. Chowkhamba Sanskrit Series Office, Varanasi.

29. Bhudeb Mookerjee (1998): Rasa-Jala-Nidhi or Ocean of Indian chemistry, Medicine & Alchemy. Vol.1Chaukhambbha publishers, Varanasi.

30. Trimbaknath Sharma (2001). Rasamitra. Chaukhanbha Sanskrit series office, Varanasi.31. Pandit Dattaram Chobe(2000): Bruhat Rasarajasundara. Chaukhambha Orientalia,

Varanasi; 234.32. Acharya Shri Madhava (2007). Ayurvedaprakasha. Edited with the Arthavidyotini &

Arthaprakasini Sanskrit & Hindi commentaries by Vaidy Vachaspati Shri Gulraj Mishra, Chaukhamba bharati Academy, Vatranasi.

33. Anonymous (2005). Bharatbhaishajyaratnakara, edited by Nagindas Chhaganlal Shah, B Jain Publishers, New Delhi.

34. Mishra Brahma Shankar (2005): Bhavaprakasha Samhita. Part- 2. Chaukhambha Sasnskrit Sansthan, Varanasi.

35. Anonymous (1993). Shaligrama Nighantu Bhushana, Bruhat Nighantu Ratnakar Part 7-8, by Shri Shaligramvaishyavarya. Khemaraja Shrikrishnadas Prakashana, Mumbai.

36. Anonymous (2005). Brihat yoga tarangini, Bharatbhaishajyaratnakara, edited by Nagindas Chhaganlal Shah, B Jain Publishers, New Delhi.

37. Shodhala (2003). Gada nigraha, With Hindi commentary ‘Vidyotani’ by Shri Indradev Tripathi. edited by Shri Gangasahay Pandey . Chaukhambha Sanskrit prakashan,Varanasi.

38. Bhishagvara Krishnashashtri navare (2011): Nighantu Ratnakara. Chaukhmbha Sanskrit Pratishthan, Delhi.

39. Acharya Anantadev Soori (2003). Rasachintamani. Translated by Prof. Siddhinandana Mishra. Chaukhamba publishers, Varanasi.

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40. Bhisgvara Jananachandra Sharma (2003). Rasakaumudi. Edited by Sri Bhahmasankar Mishra . Chaukhamba bharati academy, Varanasi.

41. Anonymous (2005). Brihat yoga tarangini, Bharatbhaishajyaratnakara, edited by Nagindas Chhaganlal Shah. B Jain Publishers, New Delhi.

42. Acharya Yashodhara (1998). Rasaprakashasudhakara. Translated by Siddhinandana Mishra . Chaukhamba Orientalia, Varanasi.

43. Anonymous (2005). Brihat yoga tarangini, Bharatbhaishajyaratnakara, edited by Nagindas Chhaganlal Shah. B Jain Publishers, New Delhi.

44. Ambikadatta Shastri (2010): Rasaratnasamuchhaya. Chaukhamba amarabharati Prakashana, Varanasi.

45. Siddha Nityanatha (2001). Rasaratnakara. Hindi commentary by Lt. Lala Shalagramaji Khemraj Shrikrishnadas Prakashana, Mumbai.

46. Anonymous (2005). Brihat yoga tarangini, Bharatbhaishajyaratnakara, edited by Nagindas Chhaganlal Shah .B Jain Publishers, New Delhi.

47. Kayastha camunda (2005). Rasa Sanketa Kalika. English translated by Uttam Vaidya and Prammi Satyagraha Sastry. Chowkhambha Krishnadas Academy, Varanasi.

48. Sadananda sharma (2009). Rasa tarangini, edited by Kashinath shastri, Motilal banarasidas publishers, New delhi.

49. Datto Balllal Borkar (1983). Rasachandanshu. Shri Gajanan Book Depo, Pune.50. Sri Chudamani Mishra (1999). Rasakamdhenu. “Suvivrtti” hindi commentary by Sri

Gulraj Sharma Mishra and Vd. Santosh Kumar Sharma. Chaukhamba Orientalia, Varanasi.

51. Acharya Shalinath: Rasamanjari. Siddhiprada hindi translated by Prof. Siddhinandan Mishra (2003). Chaukhamba Orientalia,Varanasi.

52. Trayambakanath sharma (2001). Rasamrita. Choukhambha Sanskrit series office, Varanasi.

53. Shyamsundaracharya Vaishya (2005). Rasayanasara. Chokhamba Krishnadas Academy, Varanasi.

54. Vaidya Pandit Hari prapannaji (2010). Rasayogasagara with Sanskrit and English introduction & Notes. Vol. 1, Choukhambha Krishnadas Academy, Varanasi.

55. Acharya Dhundhuknath (2000). Rasendrachintamani with ‘Siddhiprada’ commentary. Hindi translated by Prof. Siddhinandan Mishra. Chaukhamba orientalia, Varanasi.

56. Ramatej Pandey and Neelakantha Mishra (2000). Rasendrasara samgraha with Rasayani hindi commentary. Chaukhamba Sanskrit Pratisthana, Delhi.

57. Anonymous (2004). Sahasrayoga, Sanskrit-Hindi-English anuvada, transaleted by Dr.Ramnivas Sharma and Dr. Surendra Sharma, Reprint edition. Chaukhmbha Sanskrit Pratisthana, Delhi.

58. Vangasena (2009). Vangasenasamhita, with ‘Hari’ commentary by Pandit Hariharaprasad Trivedi, 1st edition. Chaukhambha Sanskrita Series Office, Varanasi.

59. Acharya Madhav (2007). Vrinda madhav, edited and translated by Premvati tewari, 1st edition . Chaukhambha Visvabharati, Varanasi.

60. Shri Trimalla Bhatt (1956). Yogatarangini samhita, edited by Acharya Shri Shricharantirth Maharaj, The Rasashala Aushadhashrama, Gondal.

61. Trimalla Bhatta (2003). Yogatarangini, Chaukhamba Vidya Bhavana, Varanasi.62. Anonymous (2008). Yogaratnakar with ‘Vidyotini’ Hindi commentary by

VaidyaLakshmipati Shastri, edited by Brahmashankara Shastri. Chaukhambha Prakashan, Varanasi.

63. Anonymous: Ayurvedic Formulary of India, part-1. New Delhi. Government of India, Ministry of health and family welfare, Dept. of Indian system of medicine & Homoeopathy, The Controller of publications.;1978

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bl 'kks/k i= esa fot;k ls lEcaf/kr lwpukvksa dks fofHkUu izfl) vk;qosZfnd xzaFkks tSls] lfgarkvksa] laxzg xzaFkks] fpfdRlk xzaFkks] jl xzaFkks] vkSj fu?k.Vqvksa ls ,d= fd;k x;k gS vkSj ;g ns[kk x;k gS fd ;g vkS"kf/k 191 ;ksxksa esa ç;ksx fd x;h gS] tks fd 29 ls vf/kd jksxksa esa ykHknk;d gSA tks fd bl çdkj gS xzg.kh ¼ekyCl‚I’kZu flaMªksEl½] Toj ¼Qhoj½] vfrlkj] vfXueka|] vth.kZ ¼fMlisfIl;k½] fgDdk ¼;wfjujh fMlv‚MZj½] laxzg.kh ¼bfjZVscy cksosy flaMªksEl@ekyCl‚I’kZu½] f’kjksjksx ¼f’kj 'kwy & gsM,d½] dkl ¼dQ½] dq"B ¼fMtht v‚Q+ fLdu½] ik.Mq ¼,uhfe;k½] Tojfrlkj] 'kksFk] 'kwy ¼dksfyd½] vfHkU;kl Toj ¼eSfuatkbfVl½] fgDdk Üokl ¼fgDdwi fMlfu;k@vLFkek½] esnksjksx ¼vkscsflVh½] 'khrfiÙk] blds vfrfjä oSn jl] xq.k] oh;Z] foikd] ,oa nks"kdeksZ ds }kjk bldk iz;ksx ;qfäiwoZd fofHkUu jksxksa esa dj ldrk gSA fu/kkZfjr 'kks/ku çfØ;k ds }kjk 'kq) djus ds iÜpkr] iz;ksT;kax ds :i esa blds i=ksa dks 125&250 fexzk- dh ek=k esa mi;ksx djrs gSaA bl vkS"kf/k dks fofHkUu :i esa tSls vfj"V] vklo] voysg] pw.kZ] ?k`r] xqfVdk] DokFk] ykSg] eksnd] iqVikd vkfn ds :i esa mi;ksx djrs gSA vkèkqfud le; esa bldk iz;ksx dSalj dh fpfdRlk ls gq, miæo tSls osnuk oeu dks de djus esa fd;k tk jgk gSaA

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