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Transcript of Jorge Flechas MD, MPH Hendersonville, NC 28792 ... TO TREAT FIBROMYALGIA AND SOCIAL ISOLATION Jorge...
OXYTOCIN TO TREAT FIBROMYALGIA AND SOCIAL ISOLATION
Jorge Flechas MD MPHHendersonville NC 28792
Oxytocin and Stem Cells
Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes
There is a oxytocinoxytocin receptor (OTOTR) system in the heart Activation of cardiac OTR stimulates the release of atrialnatriuretic peptide (ANP) which is involved in regulation of blood pressure and cell growth
Oxytocin and Stem cells
OTOTR system plays an important role in cardiogenesis by promoting cardiomyocyte differentiation
Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes Joanne PaquindaggerDagger Bogdan A Danalachedaggersect Marek Jankowskisect Samuel M McCannpara and Jolanta Gutkowskasect Laboratoire de Neuroendocrinologie Deacuteveloppementale Deacutepartementde Chimie et de Biochimie Universiteacute du Queacutebec Montreal QC Canada H3C 3P8 sectLaboratoire de BiochimieCardiovasculaire Centre Hospitalier de lrsquoUniversiteacute de Montreacuteal (CHUM) Hoˆ tel-Dieu Montreal QC Canada H2W 1T7 and paraPennington Biomedical Research Center Louisiana State University Baton Rouge LA 70808-4124
Oxytocin and Osteoporosis
Oxytocin Controls Differentiation of Human Mesenchymal Stem Cells and Reverses Osteoporosis
STEM CELLS
Volume 26 Issue 9 pages 2399ndash2407 September 2008
Oxytocin and Osteoporosis
ovariectomized (OVX) mice and rats which become osteoporotic and exhibit disequilibrium of osteoblasts and adipocytes which share the same precursor cell and an inverse relationship exists between the two lineages Therefore identifying signaling pathways that stimulate mesenchymal stem cells osteogenesis at the expense of adipogenesis balance have significant decreased OT levels compared to sham-operated controls Subcutaneous OT injection reverses bone loss in OVX mice and reduces marrow adiposity Clinically plasma OT levels are significantly lower in postmenopausal women developing osteoporosis than in their healthy counterparts Taken together these results suggest that plasma OT levels represent a novel diagnostic marker for osteoporosis and that OT administration holds promise as a potential therapy for this disease
Oxytocin and Muscle Maintenance
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
Published 10 Jun 2014
Christian Elabd et all
DOI 101038ncomms5082
1
NATURE COMMUNICATIONS
| 54082 | DOI 101038ncomms5082 | wwwnaturecomnaturecommunications
Macmillan Publishers Limited All rights reserved
Oxytocin levels Decline with age
The regenerative capacity of skeletal muscle declines with age Previous studies suggest that
this process can be reversed by exposure to young circulation however systemic age-specific
factors responsible for this phenomenon are largely unknown Here we report that
oxytocinmdasha hormone best known for its role in lactation parturition and social behavioursmdashis
required for proper muscle tissue regeneration and homeostasis and that plasma levels of
oxytocin decline with age
Oxytocin Signaling
Inhibition of oxytocin signalling in young animals reduces muscle
regeneration whereas systemic administration of oxytocinrapidly improves muscle
regeneration by enhancing aged muscle stem cell activationproliferation They further show that the genetic lack of
Oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia
Considering that oxytocin is an FDA-approved drug this work reveals a potential novel and
safe way to combat or prevent skeletal muscle ageing
Fibromyalgia and Oxytocin
Plasma oxytocin levels in female fibromyalgia syndrome
Zeitschrift fuumlrRheumatologie gt 2000 gt 59 gt 6 gt 373-379
Fibromyalgia and Oxytocin
Fibromyalgia syndrome (FMS) is a chronic pain disorder where 90 of the patients struck by the disorder are women The neuropeptide oxytocinis known to have antinociceptive and analgesic as well as anxiolytic and antidepressant effects which makes this neuropeptide of interest in fibromyalgia research The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain stress depression anxiety and to the positive item happiness
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin and Stem Cells
Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes
There is a oxytocinoxytocin receptor (OTOTR) system in the heart Activation of cardiac OTR stimulates the release of atrialnatriuretic peptide (ANP) which is involved in regulation of blood pressure and cell growth
Oxytocin and Stem cells
OTOTR system plays an important role in cardiogenesis by promoting cardiomyocyte differentiation
Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes Joanne PaquindaggerDagger Bogdan A Danalachedaggersect Marek Jankowskisect Samuel M McCannpara and Jolanta Gutkowskasect Laboratoire de Neuroendocrinologie Deacuteveloppementale Deacutepartementde Chimie et de Biochimie Universiteacute du Queacutebec Montreal QC Canada H3C 3P8 sectLaboratoire de BiochimieCardiovasculaire Centre Hospitalier de lrsquoUniversiteacute de Montreacuteal (CHUM) Hoˆ tel-Dieu Montreal QC Canada H2W 1T7 and paraPennington Biomedical Research Center Louisiana State University Baton Rouge LA 70808-4124
Oxytocin and Osteoporosis
Oxytocin Controls Differentiation of Human Mesenchymal Stem Cells and Reverses Osteoporosis
STEM CELLS
Volume 26 Issue 9 pages 2399ndash2407 September 2008
Oxytocin and Osteoporosis
ovariectomized (OVX) mice and rats which become osteoporotic and exhibit disequilibrium of osteoblasts and adipocytes which share the same precursor cell and an inverse relationship exists between the two lineages Therefore identifying signaling pathways that stimulate mesenchymal stem cells osteogenesis at the expense of adipogenesis balance have significant decreased OT levels compared to sham-operated controls Subcutaneous OT injection reverses bone loss in OVX mice and reduces marrow adiposity Clinically plasma OT levels are significantly lower in postmenopausal women developing osteoporosis than in their healthy counterparts Taken together these results suggest that plasma OT levels represent a novel diagnostic marker for osteoporosis and that OT administration holds promise as a potential therapy for this disease
Oxytocin and Muscle Maintenance
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
Published 10 Jun 2014
Christian Elabd et all
DOI 101038ncomms5082
1
NATURE COMMUNICATIONS
| 54082 | DOI 101038ncomms5082 | wwwnaturecomnaturecommunications
Macmillan Publishers Limited All rights reserved
Oxytocin levels Decline with age
The regenerative capacity of skeletal muscle declines with age Previous studies suggest that
this process can be reversed by exposure to young circulation however systemic age-specific
factors responsible for this phenomenon are largely unknown Here we report that
oxytocinmdasha hormone best known for its role in lactation parturition and social behavioursmdashis
required for proper muscle tissue regeneration and homeostasis and that plasma levels of
oxytocin decline with age
Oxytocin Signaling
Inhibition of oxytocin signalling in young animals reduces muscle
regeneration whereas systemic administration of oxytocinrapidly improves muscle
regeneration by enhancing aged muscle stem cell activationproliferation They further show that the genetic lack of
Oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia
Considering that oxytocin is an FDA-approved drug this work reveals a potential novel and
safe way to combat or prevent skeletal muscle ageing
Fibromyalgia and Oxytocin
Plasma oxytocin levels in female fibromyalgia syndrome
Zeitschrift fuumlrRheumatologie gt 2000 gt 59 gt 6 gt 373-379
Fibromyalgia and Oxytocin
Fibromyalgia syndrome (FMS) is a chronic pain disorder where 90 of the patients struck by the disorder are women The neuropeptide oxytocinis known to have antinociceptive and analgesic as well as anxiolytic and antidepressant effects which makes this neuropeptide of interest in fibromyalgia research The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain stress depression anxiety and to the positive item happiness
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin and Stem cells
OTOTR system plays an important role in cardiogenesis by promoting cardiomyocyte differentiation
Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes Joanne PaquindaggerDagger Bogdan A Danalachedaggersect Marek Jankowskisect Samuel M McCannpara and Jolanta Gutkowskasect Laboratoire de Neuroendocrinologie Deacuteveloppementale Deacutepartementde Chimie et de Biochimie Universiteacute du Queacutebec Montreal QC Canada H3C 3P8 sectLaboratoire de BiochimieCardiovasculaire Centre Hospitalier de lrsquoUniversiteacute de Montreacuteal (CHUM) Hoˆ tel-Dieu Montreal QC Canada H2W 1T7 and paraPennington Biomedical Research Center Louisiana State University Baton Rouge LA 70808-4124
Oxytocin and Osteoporosis
Oxytocin Controls Differentiation of Human Mesenchymal Stem Cells and Reverses Osteoporosis
STEM CELLS
Volume 26 Issue 9 pages 2399ndash2407 September 2008
Oxytocin and Osteoporosis
ovariectomized (OVX) mice and rats which become osteoporotic and exhibit disequilibrium of osteoblasts and adipocytes which share the same precursor cell and an inverse relationship exists between the two lineages Therefore identifying signaling pathways that stimulate mesenchymal stem cells osteogenesis at the expense of adipogenesis balance have significant decreased OT levels compared to sham-operated controls Subcutaneous OT injection reverses bone loss in OVX mice and reduces marrow adiposity Clinically plasma OT levels are significantly lower in postmenopausal women developing osteoporosis than in their healthy counterparts Taken together these results suggest that plasma OT levels represent a novel diagnostic marker for osteoporosis and that OT administration holds promise as a potential therapy for this disease
Oxytocin and Muscle Maintenance
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
Published 10 Jun 2014
Christian Elabd et all
DOI 101038ncomms5082
1
NATURE COMMUNICATIONS
| 54082 | DOI 101038ncomms5082 | wwwnaturecomnaturecommunications
Macmillan Publishers Limited All rights reserved
Oxytocin levels Decline with age
The regenerative capacity of skeletal muscle declines with age Previous studies suggest that
this process can be reversed by exposure to young circulation however systemic age-specific
factors responsible for this phenomenon are largely unknown Here we report that
oxytocinmdasha hormone best known for its role in lactation parturition and social behavioursmdashis
required for proper muscle tissue regeneration and homeostasis and that plasma levels of
oxytocin decline with age
Oxytocin Signaling
Inhibition of oxytocin signalling in young animals reduces muscle
regeneration whereas systemic administration of oxytocinrapidly improves muscle
regeneration by enhancing aged muscle stem cell activationproliferation They further show that the genetic lack of
Oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia
Considering that oxytocin is an FDA-approved drug this work reveals a potential novel and
safe way to combat or prevent skeletal muscle ageing
Fibromyalgia and Oxytocin
Plasma oxytocin levels in female fibromyalgia syndrome
Zeitschrift fuumlrRheumatologie gt 2000 gt 59 gt 6 gt 373-379
Fibromyalgia and Oxytocin
Fibromyalgia syndrome (FMS) is a chronic pain disorder where 90 of the patients struck by the disorder are women The neuropeptide oxytocinis known to have antinociceptive and analgesic as well as anxiolytic and antidepressant effects which makes this neuropeptide of interest in fibromyalgia research The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain stress depression anxiety and to the positive item happiness
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin and Osteoporosis
Oxytocin Controls Differentiation of Human Mesenchymal Stem Cells and Reverses Osteoporosis
STEM CELLS
Volume 26 Issue 9 pages 2399ndash2407 September 2008
Oxytocin and Osteoporosis
ovariectomized (OVX) mice and rats which become osteoporotic and exhibit disequilibrium of osteoblasts and adipocytes which share the same precursor cell and an inverse relationship exists between the two lineages Therefore identifying signaling pathways that stimulate mesenchymal stem cells osteogenesis at the expense of adipogenesis balance have significant decreased OT levels compared to sham-operated controls Subcutaneous OT injection reverses bone loss in OVX mice and reduces marrow adiposity Clinically plasma OT levels are significantly lower in postmenopausal women developing osteoporosis than in their healthy counterparts Taken together these results suggest that plasma OT levels represent a novel diagnostic marker for osteoporosis and that OT administration holds promise as a potential therapy for this disease
Oxytocin and Muscle Maintenance
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
Published 10 Jun 2014
Christian Elabd et all
DOI 101038ncomms5082
1
NATURE COMMUNICATIONS
| 54082 | DOI 101038ncomms5082 | wwwnaturecomnaturecommunications
Macmillan Publishers Limited All rights reserved
Oxytocin levels Decline with age
The regenerative capacity of skeletal muscle declines with age Previous studies suggest that
this process can be reversed by exposure to young circulation however systemic age-specific
factors responsible for this phenomenon are largely unknown Here we report that
oxytocinmdasha hormone best known for its role in lactation parturition and social behavioursmdashis
required for proper muscle tissue regeneration and homeostasis and that plasma levels of
oxytocin decline with age
Oxytocin Signaling
Inhibition of oxytocin signalling in young animals reduces muscle
regeneration whereas systemic administration of oxytocinrapidly improves muscle
regeneration by enhancing aged muscle stem cell activationproliferation They further show that the genetic lack of
Oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia
Considering that oxytocin is an FDA-approved drug this work reveals a potential novel and
safe way to combat or prevent skeletal muscle ageing
Fibromyalgia and Oxytocin
Plasma oxytocin levels in female fibromyalgia syndrome
Zeitschrift fuumlrRheumatologie gt 2000 gt 59 gt 6 gt 373-379
Fibromyalgia and Oxytocin
Fibromyalgia syndrome (FMS) is a chronic pain disorder where 90 of the patients struck by the disorder are women The neuropeptide oxytocinis known to have antinociceptive and analgesic as well as anxiolytic and antidepressant effects which makes this neuropeptide of interest in fibromyalgia research The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain stress depression anxiety and to the positive item happiness
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin and Osteoporosis
ovariectomized (OVX) mice and rats which become osteoporotic and exhibit disequilibrium of osteoblasts and adipocytes which share the same precursor cell and an inverse relationship exists between the two lineages Therefore identifying signaling pathways that stimulate mesenchymal stem cells osteogenesis at the expense of adipogenesis balance have significant decreased OT levels compared to sham-operated controls Subcutaneous OT injection reverses bone loss in OVX mice and reduces marrow adiposity Clinically plasma OT levels are significantly lower in postmenopausal women developing osteoporosis than in their healthy counterparts Taken together these results suggest that plasma OT levels represent a novel diagnostic marker for osteoporosis and that OT administration holds promise as a potential therapy for this disease
Oxytocin and Muscle Maintenance
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
Published 10 Jun 2014
Christian Elabd et all
DOI 101038ncomms5082
1
NATURE COMMUNICATIONS
| 54082 | DOI 101038ncomms5082 | wwwnaturecomnaturecommunications
Macmillan Publishers Limited All rights reserved
Oxytocin levels Decline with age
The regenerative capacity of skeletal muscle declines with age Previous studies suggest that
this process can be reversed by exposure to young circulation however systemic age-specific
factors responsible for this phenomenon are largely unknown Here we report that
oxytocinmdasha hormone best known for its role in lactation parturition and social behavioursmdashis
required for proper muscle tissue regeneration and homeostasis and that plasma levels of
oxytocin decline with age
Oxytocin Signaling
Inhibition of oxytocin signalling in young animals reduces muscle
regeneration whereas systemic administration of oxytocinrapidly improves muscle
regeneration by enhancing aged muscle stem cell activationproliferation They further show that the genetic lack of
Oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia
Considering that oxytocin is an FDA-approved drug this work reveals a potential novel and
safe way to combat or prevent skeletal muscle ageing
Fibromyalgia and Oxytocin
Plasma oxytocin levels in female fibromyalgia syndrome
Zeitschrift fuumlrRheumatologie gt 2000 gt 59 gt 6 gt 373-379
Fibromyalgia and Oxytocin
Fibromyalgia syndrome (FMS) is a chronic pain disorder where 90 of the patients struck by the disorder are women The neuropeptide oxytocinis known to have antinociceptive and analgesic as well as anxiolytic and antidepressant effects which makes this neuropeptide of interest in fibromyalgia research The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain stress depression anxiety and to the positive item happiness
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin and Muscle Maintenance
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
Published 10 Jun 2014
Christian Elabd et all
DOI 101038ncomms5082
1
NATURE COMMUNICATIONS
| 54082 | DOI 101038ncomms5082 | wwwnaturecomnaturecommunications
Macmillan Publishers Limited All rights reserved
Oxytocin levels Decline with age
The regenerative capacity of skeletal muscle declines with age Previous studies suggest that
this process can be reversed by exposure to young circulation however systemic age-specific
factors responsible for this phenomenon are largely unknown Here we report that
oxytocinmdasha hormone best known for its role in lactation parturition and social behavioursmdashis
required for proper muscle tissue regeneration and homeostasis and that plasma levels of
oxytocin decline with age
Oxytocin Signaling
Inhibition of oxytocin signalling in young animals reduces muscle
regeneration whereas systemic administration of oxytocinrapidly improves muscle
regeneration by enhancing aged muscle stem cell activationproliferation They further show that the genetic lack of
Oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia
Considering that oxytocin is an FDA-approved drug this work reveals a potential novel and
safe way to combat or prevent skeletal muscle ageing
Fibromyalgia and Oxytocin
Plasma oxytocin levels in female fibromyalgia syndrome
Zeitschrift fuumlrRheumatologie gt 2000 gt 59 gt 6 gt 373-379
Fibromyalgia and Oxytocin
Fibromyalgia syndrome (FMS) is a chronic pain disorder where 90 of the patients struck by the disorder are women The neuropeptide oxytocinis known to have antinociceptive and analgesic as well as anxiolytic and antidepressant effects which makes this neuropeptide of interest in fibromyalgia research The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain stress depression anxiety and to the positive item happiness
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin levels Decline with age
The regenerative capacity of skeletal muscle declines with age Previous studies suggest that
this process can be reversed by exposure to young circulation however systemic age-specific
factors responsible for this phenomenon are largely unknown Here we report that
oxytocinmdasha hormone best known for its role in lactation parturition and social behavioursmdashis
required for proper muscle tissue regeneration and homeostasis and that plasma levels of
oxytocin decline with age
Oxytocin Signaling
Inhibition of oxytocin signalling in young animals reduces muscle
regeneration whereas systemic administration of oxytocinrapidly improves muscle
regeneration by enhancing aged muscle stem cell activationproliferation They further show that the genetic lack of
Oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia
Considering that oxytocin is an FDA-approved drug this work reveals a potential novel and
safe way to combat or prevent skeletal muscle ageing
Fibromyalgia and Oxytocin
Plasma oxytocin levels in female fibromyalgia syndrome
Zeitschrift fuumlrRheumatologie gt 2000 gt 59 gt 6 gt 373-379
Fibromyalgia and Oxytocin
Fibromyalgia syndrome (FMS) is a chronic pain disorder where 90 of the patients struck by the disorder are women The neuropeptide oxytocinis known to have antinociceptive and analgesic as well as anxiolytic and antidepressant effects which makes this neuropeptide of interest in fibromyalgia research The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain stress depression anxiety and to the positive item happiness
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin Signaling
Inhibition of oxytocin signalling in young animals reduces muscle
regeneration whereas systemic administration of oxytocinrapidly improves muscle
regeneration by enhancing aged muscle stem cell activationproliferation They further show that the genetic lack of
Oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia
Considering that oxytocin is an FDA-approved drug this work reveals a potential novel and
safe way to combat or prevent skeletal muscle ageing
Fibromyalgia and Oxytocin
Plasma oxytocin levels in female fibromyalgia syndrome
Zeitschrift fuumlrRheumatologie gt 2000 gt 59 gt 6 gt 373-379
Fibromyalgia and Oxytocin
Fibromyalgia syndrome (FMS) is a chronic pain disorder where 90 of the patients struck by the disorder are women The neuropeptide oxytocinis known to have antinociceptive and analgesic as well as anxiolytic and antidepressant effects which makes this neuropeptide of interest in fibromyalgia research The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain stress depression anxiety and to the positive item happiness
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Fibromyalgia and Oxytocin
Plasma oxytocin levels in female fibromyalgia syndrome
Zeitschrift fuumlrRheumatologie gt 2000 gt 59 gt 6 gt 373-379
Fibromyalgia and Oxytocin
Fibromyalgia syndrome (FMS) is a chronic pain disorder where 90 of the patients struck by the disorder are women The neuropeptide oxytocinis known to have antinociceptive and analgesic as well as anxiolytic and antidepressant effects which makes this neuropeptide of interest in fibromyalgia research The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain stress depression anxiety and to the positive item happiness
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Fibromyalgia and Oxytocin
Fibromyalgia syndrome (FMS) is a chronic pain disorder where 90 of the patients struck by the disorder are women The neuropeptide oxytocinis known to have antinociceptive and analgesic as well as anxiolytic and antidepressant effects which makes this neuropeptide of interest in fibromyalgia research The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain stress depression anxiety and to the positive item happiness
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Fibromyalgia and oxytocin
Methods Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls Besides the daily ratings depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI)
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Fibromyalgia and Oxytocin
Results Depressed patients according to the BDI differed significantly with low levels of oxytocincompared to the non-depressed patients and the controls Low levels of oxytocin were also seen in high scoring pain stress and depression patients according to the daily ratings however these subgroups were small A negative correlation was found between the scored symptoms depression and anxiety and oxytocinconcentration and a positive correlation between the item happiness and oxytocin
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburloa et al
Psychoneuroendocrinology (2007) 32 407ndash410
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin is Antistress
Cerebrospinal fluid and plasmatic levels of oxytocin(OT) have been found to change in mood disorders In post-mortem studies the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased Moreover OT is considered as an endogenous antistress hormone It has also revealed antidepressive effects OT may contribute to the dysregulation of the HPA system in major depression Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r frac14 058 p frac14 0003) and anxiety (r frac14 061 p frac14 0005)
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin and social behavior
Oxytocin vasopressin and human social behavior
Markus Heinrichs Bernadette von Dawans
Frontiers in Neuroendocrinology 30 (2009) 548ndash557Gregor Domes
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
A better understanding of the neurobiology and neurogenetics of human social cognition and behavior has important implications for the current development of novel clinical approaches for mental disorders that are associated with social deficits (eg autism spectrum disorder social anxiety disorder and borderline personality disorder) This review focuses on our recent knowledge of the behavioral endocrine genetic and neural effects of OT and AVP in humans and provides a synthesis of recent advances made in the effort to implicate the oxytocinergic system in the treatment of psychopathological states
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Autism and oxytocin
Plasma Oxytocin Levels in Autistic Children
Charlotte Modahl LeeAnne Green Deborah Fein Mariana Morris Lynn Waterhouse Carl Feinstein and Harriet Levin
BIOL PSYCHIATRY 271 199843270-277
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Table 2 Levels of Plasma OT in Autistic and Normal Children (pgmL)
Autistic (n = 29) Normal (n = 30)
Mean (SD) 064 (058) 116 (077)
Median 045 106
Range 0-248 0-272
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin and Autistic Disorder Alterations in Peptide Forms
LeeAnne Green Deborah Fein Charlotte Modahl Carl Feinstein Lynn Waterhouse and Mariana Morris
Biol Psychiatry 200150609ndash613 copy 2001 Society of Biological Psychiatry
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin (OT) is synthesized as a prohormonethat is sequentially processed to peptides These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides OT-Gly OT-Gly-Lys and OT-Gly-Lys-Arg which are designated together as OT-X As an extension of our previous study finding decreased plasma OT in autism studies were conducted to determine whether there were changes in OT peptide forms in autistic children
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Oxytocin levels in Autism
Plasma levels of OT were lower in the autistic group (8 09) than in the control group (14 10) whereas OT-X levels were higher (autistic 29 29 control 20 22 t 23 p 03) The ratio between OT-X and OT was much higher in the autistic group (47 59) compared to the control group (18 25 t 45 p 0001) with a more than two-fold difference
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
Target tissue of oxytocin is the Amygdala of the brain
See my lecture on wwwyoutubecom
Flechas autism oxytocin
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
Hideyuki Inoue et al
DOI httpdxdoiorg101016jbiopsych201007019
