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Jonathan Chernoff, M.D., Ph.D. Fox Chase Cancer Center 344 Evergreen Road 333 Cottman Avenue Jenkintown, PA 19046 Philadelphia, PA 19111 (215) 572-0214 (215) 728-5319 (215) 728 3616 (fax) J_Chernoff@fccc.edu Personal Birthdate: April 21, 1957 Birthplace: New Haven, CT Citizenship: U.S.A. Education 1978 Yale College, B.A. Molecular Biophysics and Biochemistry 1984 Mount Sinai School of Medicine, M.D. and Ph.D. (Medical Scientist Training Program). Ph.D. Discipline: Biochemistry Postdoctoral Training 7/84-6/87 Resident Department of Internal Medicine University Health Center of Pittsburgh 7/87-6/88 Clinical Fellow Department of Medical Oncology The Johns Hopkins Oncology Center 7/88-7/90 Clinical Fellow Hematology/Oncology Department Beth Israel Hospital 7/88-8/91 Postdoctoral Fellow (Erikson lab) Department of Cellular and Developmental Biology Harvard University Faculty Appointments 9/91-12/96 Associate Member (= Assistant Professor) Fox Chase Cancer Center

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12/96-6/02 Member (with tenure) (= Associate Professor) Fox Chase Cancer Center 12/96-present Adjunct Assistant Professor University of Pennsylvania 4/99-present co-Director, Program in Cancer Biology Fox Chase Cancer Center 6/02-present Senior Member (= Professor) Fox Chase Cancer Center 1/04-present Adjunct Professor Drexel University School of Medicine 12/08-present Stanley Reimann Chair in Oncology Research Fox Chase Cancer Center 12/08-8/10 Vice-President, Deputy Scientific Director Fox Chase Cancer Center 7/10-present Adjunct Professor University of Pennsylvania 8/10-present Scientific Director. Senior Vice-President, Deputy Cancer Center Director Fox Chase Cancer Center Grants (past) Medical Scientist Training Grant 9/78-6/84 PHS NRSA Postdoctoral Grant 7/89-7/91 NIH 1 RO1 CA58836: "A Tumor Suppressing Protein Tyrosine Phosphatase". 1/93-1/98, 1/98-1/03, 1/03-1/08 Council for Tobacco Research, #3480: "Protein Tyrosine Phosphatases as Signal Transduction Probes". 1/93-1/96 W.W. Smith Foundation #C9201: "Proteins Required for Transformation by the v-src Gene". 1/93-1/96

Institutional Pilot Project Grant: "Genetic strategies for Identifying Proteins Involved in Cell Polarity Control". 7/96-7/97

NIH 1 RO1 GM54168: "Regulation of p21-activated Kinases". 8/97-8/ 01 American Cancer Society, #CB-189: "Protein Kinases that Regulate Cell Shape and Polarity". 7/97-7/00, 7/00-7/02, 7/02-7/04 Leukemia Society of America (Scholar): #1005-98 7/97-7/02

PA Tobacco Formula Grant: “Assessing HER-2 Targets in Breast Cancer 1/04-1/06

DOD: NF050032: “Identification of Protein Kinases Required for NF2 Signaling” 12/05-12/07

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CTF: 2007B-05-003 “Synthetic lethal screen of FDA-approved drugs in NF2”. 9/07- 9/08

DOD: NF050030: “Analysis of p21-Activated Kinase Function in Neurofibromatosis Type 2” 12/05-12/09 1,200,000 direct costs Seed Grant: FCCC “Identification of key signaling enzymes required for

embryonic stem cell pluripotency” 7/08- 7/10 150,000 direct costs CTF: 2009A-05-002: “Use of Induced Progenitor Stem Cells to Treat NF1”

9/09 – 9/10 30,000, direct costs American Asthma Foundation: “p21-Activated Kinase-1 as a Novel

Therapeutic Target in Asthma” 7/08-7/11 750,000 direct costs NIH 1 RO1 CA117884-8: "Function of p21-activated Kinases". 1/07-1/12 1,050,000 direct costs

DOD NF093118: “Role of p21-Activated Protein Kinases in Neurofibromatosis 2 6/10 – 6/12 174,500 total costs

(H.-Y. Chow, postdoctoral fellowship) SPORE pilot project: “p21-activated kinases as therapeutic targets in ovarian

cancer” 12/11 – 12/12 50,000 total costs BSF: 2007038 “Spatio-temporal regulation of p21-activated kinases (Pak)

in a T cell model system” 7/08- 7/12 180,000 direct costs DOD NF093039: “Use of Induced Progenitor Stem Cells to Treat NF1” 6/10 – 6/12 150,000 direct costs DOD BC097800: “Role of PTP1B in HER2 Signaling in Breast Cancer” 10/10 – 10/13 523,000 total costs (S. Saha, postdoctoral fellowship) CTF Preclinical Consortium Center: “Preclinical drug testing in NF2” 11/11 – 11/13 250,000 total costs DOD NF130108: “Testing the Role of p21-Activated Kinases in Schwannoma

Formation Using a Novel Genetically Engineered Murine Model that Closely Phenocopies Human NF2 Disease”

4/14 – 4/17 575,000 direct costs Breast Cancer Alliance Exceptional Project Grant: “Dissecting a Breast

Cancer Amplicon using CRISPR/Cas” 2/16 – 2/17 100,000 direct costs

Grants (present)

NIH 1 R01 CA142928: “p21-Activated Kinases as New Therapeutic Targets in Neurofibromatosis Type 1”

1/15 - 1/20 1,125,000 direct costs NIH 1 R01 CA148805: “The Role of p21-Activated Kinases in Malignant

Mesothelioma” 2/16 – 2/21 1,200,000 direct costs NIH 1 R01 CA227184: “Targeting the Rac1 Signaling Pathway in

Malignant Melanoma” 2/18 – 2/23 1,250,000 direct costs Melanoma Research Foundation: “RAC1 mutant melanoma: models and

therapeutics” 10/18 – 10/20 200,000 direct costs ACS 122275-IRG-92-027-18-IRG: “Institutional Research Grant” 6/15 – 6/18 180,000 direct costs

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NIH 1 R01 NS066927 (Jun Li, PI): “Pathophysiology of Conduction Blocks in HNPP” (subcontract from Vanderbilt)

3/14 – 3/17 66,000 direct costs NIH-T32-CA009035-41 (PI: Chernoff): “Training Program in Postdoctoral

Research” 4/16 – 4/21 P30 CA006927 (PI: Fisher): “Comprehensive Cancer Center Program at Fox Chase” 8/16 – 8/21

Honors/Awards Pfizer Travelling Fellow Award 1996 W.W. Smith Charitable Trust Fellowship 1993-1996 American Cancer Society Research Scholar 1993-1998 Leukemia Society of America (Scholar) 1997-2002 Vice-chair, Gordon Conference “Mechanisms of Cell Signalling” 2005 Vice-chair, FASEB “Small G Protein Networks in Cell Dynamics” 2006 Chair, Gordon Conference “Mechanisms of Cell Signalling” 2007 Member, Faculty of 1000 2005- Dozer Lecturer, Ben Gurion University 2007 Member, The Kinome Virtual Academy of the Targeted Proteins Database 2008- Senior Fellow, American Asthma Assn 2008-2011 NF Conference, session leader 2010

Russian Academy of Science, Conference on Gene Expression, session leader 2010 ACS Scientific Research Award, Southeast PA Region 2010 Chair: NF2 Preclinical Consortium 2011-2012 Pennsylvania Drug Discovery Institute, Drug Discovery Award 2013 AACR, Educational Session Leader 2014 Member, Interurban Clinical Club 2016- Senior Faculty Award, 4th Annual Temple Translation Science Symposium 2016 Co-organizer, Celebrating AKT 2016 Chairperson, AACR Gertrude B. Elion Cancer Research Grant Scientific Review Committee 2017 Fellow, American Association for the Advancement of Science (AAAS) 2017 Co-chair AACR Annual Meeting Program Committee 2018

Patents

U.S. Patent Application #PCT/US1998/014412 “Pak kinase genes and polypeptides and methods of use thereof”

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U.S. Patent Application #PCT/US2005/032195 “Methods for screening for inhibitors of autoinhibited proteins”

Certifications and Licensure American Board of Internal Medicine Subspecialty Board -- Medical Oncology Medical License -- Pennsylvania Consulting Scientific Advisory Board: Nexgenix Pharmaceuticals 2004-2011 Genentech 2008-2013 Novartis 2008-2011 NYU Cancer Institute EAB 2011-2016 Case Western Cancer Signaling Program EAB 2012-2014 Scientific Advisory Boards: Tarsa, Pharma-Arava, Enteris 2013-2017 External Advisory Board: U. Miami Epigenetics T32 2017- Teaching "Signal Transduction" (Postdoctoral course at FCCC) 1995 "Signalling to the Cytoskeleton", Physiology Course, Marine Biology Lab, Woods Hole 1997, 1998 "Protein-Tyrosine Phosphatases" Univ Penn BMB-550 2001-2005 "Protein Kinases" Drexel Univ SOM 2005- "Lipid Kinases and Rho Proteins" Drexel Univ SOM 2005- "Protein Kinases" Univ Penn BMB-633 2013-2014 Students and Postdoctoral fellows

High School and College students 1-2 per year since 1992 Graduate students Currently

Feng Liu 1995-1999 Wyeth Pharmaceuticals Olga Mitina 1999-2000 Univ of Munich (Warmuth lab) Mikhail Shepelev 2003-2004 Engelhardt Institute, Moscow Dina Stepanova 2006-2013 RSMU Pharmacology Dept, Moscow Sonali Jalan 2009-2016 Senior Scientist, Merck Rachelle Kosoff 2009-2014 Senior Scientist, Advaxis Mollie Kelly 2010-2014 Novira Therapeutics Galina Semenova 2011-2018 PDF, Wistar Institute Sophia Karchugina 2017- Alexa Cannon 2018- Konstantin Budagyan 2018-

Cao-Zeng 2018- Postdoctoral fellows

Caretha Creasy 1992-1995 Head, Molecular Medicine, GSK Diane Ambrose 1993-1996 Clin. Res. Ctr. UMDNJ

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Robert Louden 1997-1998 Instructor, Haverford College Melissa Reeder 1997-2002 Cell Pathways

Shrikrishna Dadke 1998-2005 Lupin Pharma, India Alexander Beeser 2001-2006 Asst. Prof, Kansas State Elena Sorokina 2002-2005 Instructor, Drexel School of Medicine

Zahara Jaffer 2000-2007 Asst. Dir., Licensing, U. Florida Clemens Hofmann 2001-2007 Sophie Cotteret 2001-2008 Res. Sci. CNRS, Gif-Sur-Yvette Almudena Pacheco 2008-2010 PDF, Drexel Univ SOM

Jenny Yip 2006-2011 Research Scientist, Target Biology Luis Arias 2006-2014 Asst. Prof, National Can. Inst. Mexico Betty Chow 2008-2018 Maria Radu 2008-2018 GSK Sayanti Saha 2008-2013 Business Development, FCCC Christine Lightcap 2008-2010 Spark Therapeutics Tatiana Prudnikova 2012- Daniela Araiza Toro 2014-2016 Asst. Prof, Inst. Quimica, UNAM Cristina Uribe Alvarez2018- FCCC Service Postdoctoral committee 1994-1997 Library committee 1997- Seminars for medical oncology fellows (1x/yr) 1997- Various promotion committees 1997- Program leader, Cancer Biology 1998- Assisted Erica Golemis with setting up FCCC/RSMU 1998-2000 sister-institution program Leap-frog lecture series 2001-2002 FCCC/Ben Gurion University program 2001- FCCC/Drexel liaison 2003- Vice-President’s Advisory Board, Basic Science 2003-2004 Appointments & Promotions 2006-2008 ECOR committee (chair) 2007- Search Committee Chair, EPC Program 2009-2010 Faculty Senate Organizing Committee 2010 Co-leader, EPC Keystone Program 2010-2011 Temple/FCCC Science Integration Committee (co-chair) 2012-2014 FCCC Internal Advisory Board 2015- Nominations Committee (chair) 2013- Editorial Duties Editorial Board: J. Biol. Chem. 1999-2005 Mol. Biol. Cell 2008- Cancer Biol. Ther. 2015-

Frequent reviewer for Nature Cell Biol., Science Signal., Mol. Cell, Curr. Biol., EMBO J., J. Cell Biol., Mol. Cell. Biol., Oncogene, and PNAS.

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Grant Study Sections Ad hoc reviewer for CDB-2 (now MBY-3) 1999, 2000 ACS Cell Signaling and Metastasis 1999, 2002- DOD NF panel A 2002 The Leukemia and Lymphoma Society 2005

Tobacco Related Disease Research Program, CA 1999-2002, 2005-2007

NIH R13 review panel 2008- Program Project Grants;

Univ Virginia PPG "Signaling in Time and Space" 1998, 2003; Univ North Carolina PPG “Biosensors for Sensitive Multiplex Analysis of Endogenous Proteins.” 2007 Univ Wisconsin PPG “Low molecular weight GTPases in vascular biology” 2007

Children’s Tumor Foundation Drug Discovery Initiative Award (co-chair) 2007-

New Jersey Commission on Cancer Research 2008-2011 AIRC - Italian Association for Cancer Research 2009- Member, College of CSR Reviewers 2010- DOD NFRP Integration panel 2010-2012 Fundacio La Murato de TV3 (Spain) 2013- Austrian Science Fund 2013- CCSG site visits: Masonic CCC, JAXCC 2013

NIH Outstanding Investigators panel (R35) 2015 AACR Basic Cancer Research Fellowships

Scientific Review Committee 2016- NIH Provocative Question (PQ6) panel 2016

CCSG site visit: Hollings CC (MUSC) 2018 NIDDK Board of Scientific Counselors Review 2018

Publications ~185, H index = 59 (Web of Science); = 65 (Google Scholar)

Refereed Articles: 1. Chernoff, J., Li, H.C., Cheng, Y.S.E. and Chen, L.B. Characterization of a phosphotyrosyl

protein phosphatase activity associated with a phosphoseryl protein phosphatase of Mr = 95,000 from bovine heart. J. Biol. Chem. 258:7852, 1983.

2. Chernoff, J. and Li, H.C. Multiple forms of phosphotyrosyl- and phosphoseryl-protein phosphatase from cardiac muscle: partial purification and characterization of an EDTA-stimulated phosphotyrosyl-protein phosphatase. Arch. Biochem. Biophys. 226:517, 1983.

3. Li, H.C., Chernoff, J., Chen, L.B. and Kirschonbaum, A. A phosphotyrosyl protein phosphatase activity associated with acid phosphatase from human prostate gland. Eur. J. Biochem. 138:45, 1984.

4. Chernoff, J., Sells, M.A. and Li, H.C. Characterization of phosphotyrosyl protein phosphatase activity associated with calcineurin. Biochem. Biophys. Res. Comm. 121:141, 1984.

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5. Sells, M.A., Chernoff, J., Cerda, A., Bowers, C., Shafritz, D.A., Kase, N., Christman, J.K. and Acs, G. Long-term culture and passage of human fetal liver cells that synthesize albumin. In Vitro Cell. Dev. Biol. 21:216, 1985.

6. Chernoff, J. and Li, H.C. A major phosphotyrosyl-protein phosphatase from bovine heart is associated with a low-molecular-weight acid phosphatase. Arch. Biochem. Biophys. 240:135, 1985.

7. Chernoff, J., Schievella, A.G., Jost, C.J., Erikson, R.L. and Neel, B.G. Cloning of the cDNA of a major human protein-tyrosine-phosphatase. Proc. Natl. Acad. Sci. USA 87:2735-2739, 1990.

8. Ottilie, S., Chernoff, J., Hannig, G., Hoffman, C.S. and Erikson, R.L. A fission yeast gene encoding a protein with features of protein-tyrosine-phosphatases. Proc. Natl. Acad. Sci. USA 88: 3455-3459, 1991.

9. Ottilie, S., Chernoff, J., Hannig, G., Hoffman, C.S. and Erikson, R.L. The fission yeast genes pyp1 and pyp2 encode protein tyrosine phosphatases that negatively regulate mitosis. Mol. Cell. Biol. 12:5571-5580, 1992.

10. Patriotis, C., Makris, A., Chernoff, J., and Tsichlis, P.N. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA 91:9755, 1994.

11. Sells, M.A. and Chernoff, J. Epitope-tagging vectors for eukaryotic protein production. Gene 152:187-189, 1995.

12. Sells, M.A, Li, J. and Chernoff, J. Delivery of protein into cells using polycationic liposomes. BioTechniques 19:72-78, 1995.

13. Knaus, U.G., Morris, S., Dong, H.-J., Chernoff, J., and Bokoch, G.M. Regulation of p21-activated kinases through G protein-coupled receptors. Science 269:221-223, 1995.

14. Creasy, C.L. and Chernoff, J. Cloning and characterization of a human protein kinase with homology to Ste20. J. Biol. Chem. 270:21695-21700, 1995.

15. Bagrodia, S., Taylor, S., Creasy, C.L., Chernoff, J., and Cerione, R.A. Identification of a murine p21Cdc42/Rac activated kinase (PAK). J. Biol. Chem. 270:22731-22738, 1995.

16. Zhang, S., Han, J., Sells, M.A., Chernoff, J., Knaus, U.G., Ulevitch, R.J., and Bokoch, G.M. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270: 23934-23936, 1995.

17. Vambutas, V., Kaplan, D.R., Sells, M.A., and Chernoff, J. NGF stimulates tyrosine phosphorylation and activation of SH-PTP1 in PC12 cells. J. Biol. Chem. 270: 25629-25634, 1995.

18. Creasy, C.L. and Chernoff, J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene 167: 303-306, 1995.

19. Ottilie, S., Miller, P.J., Johnson, D.I., Creasy, C.L., Sells, M.A., Bagrodia, S., Forsburg, S.L., and Chernoff, J. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. EMBO J. 14:5908-5919, 1995.

20. Creasy, C.L., Ambrose, D.M., and Chernoff, J. The human Ste20-like kinase, Mst1, dimerizes and contains an inhibitory domain. J. Biol. Chem. 271:21049-21053, 1996.

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21. Galisteo, M.L., Chernoff, J., Su, Y.-C., Skolnik, E.Y., and Schlessinger, J. The adaptor protein Nck links receptor tyrosine kinases with the serine/threonine kinase Pak1. J. Biol. Chem. 271:20997-21000, 1996.

22. Liu, F., Hill, D.E., and Chernoff, J. Direct binding of the proline rich region of Protein Tyrosine Phosphatase 1B to the Src homology 3 domain of p130Cas. J. Biol. Chem. 271:31290-31295, 1996.

23. Bandyopadhyay, D., Kusari, A., Kenner, K., Liu, F., Chernoff, J., Gustafson, T.A., and Kusari, J. Protein Tyrosine Phosphatase 1B binds to the insulin receptor in vivo and is tyrosine phosphorylated in the presence of insulin. J. Biol. Chem. 272:1639-1645, 1997.

24. Sells, M.A., Knaus, U.G., Bagrodia, S., Ambrose, D., Bokoch, G.M. and Chernoff, J. Human p21-activated kinases (Paks) regulate actin reorganization in mammalian cells. Curr. Biol. 7:202-210, 1997.

25. Tang, Y., Chen, Z., Ambrose, D., Liu, J., Gibbs, J.B., Chernoff, J., and Field, J. Kinase deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol. Cell. Biol. 17:4454-4464, 1997.

26. Liu, F. and Chernoff, J. Protein tyrosine phosphatase 1B interacts with epidermal growth factor receptor in cultured cells. Biochem. J. 327:139-145, 1997.

27. Liu, F., Sells, M.A., and Chernoff, J. Suppression of oncogene-mediated transformation of rat 3Y1 fibroblasts by protein tyrosine phosphatase 1B requires a functional SH3-ligand. Mol. Cell. Biol. 18:250-259, 1998.

28. Liu, F., Sells, M.A., and Chernoff, J. Protein tyrosine phosphatase 1B negatively regulates integrin signaling. Curr. Biol. 8:173-176, 1998.

29. Zhang, B., Chernoff, J., and Zheng, Y. Interaction of Rac1 with GTPases-activating proteins and putative effectors. J. Biol. Chem. 273:8776-8782, 1998.

30. Graves, J.D., Gotoh, Y., Draves, K.E. Ambrose, D., Han, D.K.N., Wright, M., Chernoff, J., Clark, E.A., Krebs, E.G. Caspase-mediated cleavage and activation of the mammalian Ste20-like kinase Mst1 during apoptosis. EMBO J. 17:2224-2234, 1998.

31. Sells, M.A., Barratt, J.T., Caviston, J., Ottilie, S., Leberer, E., and Chernoff, J. Characterization of Pak2, a pleckstrin-homology-domain-containing p21-activated protein kinase from fission yeast. J. Biol. Chem. 273:18490-18498, 1998.

32. Adam, L., Vadlamudi, R., Kondapaka, S.B., Chernoff, J., Mendelsohn, J., and Kumar, R. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J. Biol. Chem. 273:28238-28246, 1998.

33. Wardenburg, J.B., Pappu, R., Bu, J.-Y., Mayer, B., Chernoff, J., Straus, D., and Chan, A.C. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76 Immunity, 9: 607-616, 1998.

34. Sells, M.A., Boyd, J., and Chernoff, J. p21-activated kinase regulates motility in mammalian fibroblasts. J. Cell Biol. 145:837-849, 1999. (cover story)

35. Adam L, Vadlamudi RK, Mandal M, Chernoff J, and Kumar R. p21-activated kinase-1 regulates microfilament reorganization and invasiveness of breast cancer cells. J. Biol. Chem, 275:12041-12050, 2000.

36. Dadke, S, Kusari, J, and Chernoff, J. Down-regulation of insulin signaling by Protein Tyrosine Phosphatase (PTP) 1B is mediated by an N-terminal binding region. J. Biol. Chem. 275:23642-23647, 2000.

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37. Dharmawardhane, S., Schurmann, A., Sells, M.A., Chernoff, J., Schmid, S.L., and Bokoch, G.M. Regulation of macropinocytosis by p21-activated kinase-1. Mol. Biol. Cell 11:3341-3352, 2000.

38. Vadlamudi, R.K., Ratna K., Adam, L., Wang, R.-A., Mandal, M., Nguyen, D., Sahin, A., Chernoff, J., Hung, M.-C., and Kumar, R. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J. Biol. Chem. 275:36238-36244, 2000.

39. Arora, V.K., Molina, R.P., Foster, J.L., Blakemore, J.L., Chernoff, J., Fredericksen, B.L., and Garcia, J.V. Lentiviral Nef specifically activates Pak2. J. Virol. 74:11081-11087, 2000.

40. Sells, M.A., Pfaff, A., and Chernoff, J. Temporal and spatial distribution of activated Pak1 in fibroblasts. J. Cell Biol. 151:1449-1457, 2000.

41. Mota, M. Reeder, M.K., Chernoff, J., and Bazenet, C.E. Evidence for a role of mixed-lineage kinases in neuronal apoptosis. J. Neurosci. 21:4949-4957, 2001

42. Reeder, M.K., Serebriiskii, I.G., Golemis E.A., and Chernoff, J. Analysis of small GTPase signaling pathways using Pak1 mutants that selectively couple to Cdc42. J. Biol. Chem. 276:40606-40613, 2001.

43. Dadke, S. and Chernoff, J. Interaction of Protein-Tyrosine Phosphatase (PTP)1B with its substrates is influenced by two distinct binding domains. Biochem. J. 364:377-383, 2002.

44. Thiel, D.A., Reeder, M.K., Pfaff, A., Coleman, T.R., Sells, M. A., and Chernoff, J. Cell cycle regulated phosphorylation of p21-activated kinase 1 (Pak1) Curr. Biol. 12:1227-1232, 2002. Recommended at F1000 Prime (http://f1000.com/prime/1008958).

45. Li, F., Adam, L., Vadlamudi, R.K., Zhou, H., Sen, S., Chernoff, J., Mandal, M.,and Kumar, R. p21-activated kinase 1 interacts with and phosphorylates Histone H3 in breast cancer cells. EMBO Reports 3:767-773, 2002.

46. Astrinidis, A, Cash, T.P., Hunter, D.S., Walker, C.L., Chernoff, J., and Henske. E.P. Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion, and migration. Oncogene 21:8470-8476, 2002.

47. Serebriiskii, I.G., Mitina, O., Pugacheva, E., Benevolenskaya, E., Kotova, E., Toby, G.G., Khazak, V., Kaelin, W.G., Chernoff, J., and Golemis, E.A. Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome Res. 12:1785-1791, 2002.

48. Penzes, P., Beeser, A., Chernoff, J., Schiller, M.R., Eipper, B.A., Mains, R.E., and Huganir, R.L. Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rac1-GEF kalirin. Neuron 37:263-274, 2003. Recommended at F1000 Prime (http://f1000.com/prime/1011905)

49. Cheung, W.L., Ajiro, K., Samejima, K., Kloc, M., Cheung, P., Mizzen, C.A., Beeser, A., Etkin, L.D., Chernoff, J., Earnshaw, W.C., and Allis, C.D. Apoptosis in vertebrates is characterized by phosphorylation of histone H2B mediated by Mammalian Sterile Twenty kinase Cell, 113:507–517, 2003.

50. Deacon, K., Mistry, P., Chernoff, J., Blank, J.L., and Patel, R. p38 MAP kinase mediates cell death and p21-activated kinase (PAK) mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol. Biol. Cell 14:2071-2087, 2003.

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51. Cotteret, S., Jaffer, Z.M., Beeser, A. and Chernoff, J. p21-activated kinase-5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol. Cell. Biol., 23:5526-5539, 2003.

52. Zegers, M.M.P., Forget, M.A., Chernoff, J., Mostov, K.E., ter Beest, M.B.A., and Hansen, S.H. Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J., 22:4155-4165. 2003. Recommended at F1000 Prime (http://f1000.com/prime/1014981)

53. Dadke, S. and Chernoff, J. Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts. J. Biol. Chem., 278:40607-40611, 2003.

54. Cai, D., Iyer, A., Near, R.I., Felekkis, K.N., Luo, Z., Albanese, C., Peste, R.G., Chernoff, J., and Lerner, A. AND-34/BCAR3, a GDP exchange factor whose over-expression confes anti-estrogen resistance, activates Rac, PAK, and the cyclin D promoter. Cancer Res., 63:6802-6808, 2003.

55. Reynolds, L.F., de Bettigniers, C., Norton, T., Beeser, A., Chernoff, J., and Tybulewicz, V.L.J. Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J. Biol. Chem., 279:18239-18246, 2004.

56. Parsons, M., Monypenny, J., Ameer-Beg, S.M., Millard, T.H., Machesky, L.M., Peter, M., Keppler, M.D., Schiavo, G., Watson, R., Chernoff, J., Zicha, D., Vojnovic, B., Ng, T. Spatially Distinct Binding of Cdc42 to PAK1 and N-WASP in Breast Carcinoma Cells. Mol. Cell. Biol., 25:1680-1695, 2005.

57. Gonzalez Guerrico, A.M., Jaffer, Z.M., Page, R.E., Braunewell, K.-H., Chernoff, J., and Klein-Szanto, A.J.P. Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene, 24:2307-2316, 2005.

58. Leisner, T.M., Liu, M., Jaffer, Z.M., Chernoff, J., Parise, L.V. Essential role of CIB1 in regulating PAK1 activation and cell migration. J. Cell Biol., 170:465-476, 2005.

59. Beeser, A., Jaffer, Z.M., Hofmann, C., and Chernoff, J. Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J. Biol. Chem., 280:36609-36615, 2005.

60. Li, S., Depetris, R., Barford, D., Chernoff, J., and Hubbard, S.R. Crystal structure of protein tyrosine phosphatase 1B bound to the insulin receptor tyrosine kinase. Structure, 13:1643-1651, 2005. Recommended at F1000 Prime (http://f1000.com/prime/1030175)

61. Bartholomew, P.J., Jones, C.W., Benware, A., Hanks, S., Chernoff, J., and LaFlamme, S.E. Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310. Exp. Cell Res., 311:294-306, 2005.

62. Cotteret, S. and Chernoff, J. Nucleocytoplasmic shuttling of Pak5 regulates its anti-apoptotic properties. Mol. Cell Biol., 26:3215-3230, 2006.

63. ten Klooster, J.P., Jaffer, Z.M., Chernoff, J., and Hordijk, P.L. Targeting and activation of Rac1 are mediated by the exchange factor b-Pix. J. Cell Biol., 172:759-769, 2006.

64. Pirruccello, M., Sondermann, H., Pelton, J.G., Pellicena, P., Hoelz, A., Chernoff, J., Wemmer, D.E., and Kuriyan, J. Dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J. Mol. Biol., 361:312-326, 2006.

65. Thullberg, M., Gad, A., Beeser, A., Chernoff, J., and Strömblad, S. The kinase-inhibitory domain of p21-activated kinase 1(PAK1) inhibits cell cycle progression independent of PAK1 kinase activity. Oncogene, 26:1820-1828, 2007.

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66. Dadke, S., Cotteret, S., Yip, S.-C., Jaffer, Z.M., Haj, F., Ivanov A., Rauscher III, F., Shuai, K., Ng, T., Neel, B.G., and Chernoff, J. Regulation of Protein-Tyrosine Phosphatase (PTP) 1B by sumoylation Nat. Cell Biol. 9:80-85, 2007.

67. Rennefahrt, U.E.E., Deacon, S., Parker, S.A., Devarajan, K., Beeser, A., Chernoff, J., Knapp, S., Turk, B.E., and Peterson, J.R., Comprehensive specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J. Biol. Chem. 282:15667-15678, 2007.

68. Friedland, J.C., Lakins, J.N., Kazanietz, M.G., Chernoff, J., Boettiger, D., and Weaver, V.M. α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NFB-dependent apoptosis resistance in 3D mammary acini. J. Cell Sci. 120:3700-3712, 2007.

69. Mao, K., Kobayashi, S., Jaffer, Z.M., Huang, Y., Volden, P., Chernoff, J., and Liang, Q. Regulation of Akt/PKB activity by p21-activated kinase in cardiomyocytes. J. Mol. Cell. Cardiol. 44:429-434, 2008.

70. Deacon, S.W., Beeser, A., Fukui, J.A., Rennefahrt, U.E.E., Myers, C., Chernoff, J., and Peterson, J. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem. Biol., 15:322-331, 2008. (Deacon and Beeser, co-first authors).

71. McDaniel, A.S, Allen, J.D., Park, S.-J., Michels, E.G., Burgin, S.J., Chen, S., Bessler, W.K., Chernoff, J., and Clapp, D.W*. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood 112:4646-4654, 2008.

72. Smith S.D., Jaffer, Z.M., Chernoff, J., and Ridley, A.J. PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J. Cell Sci. 121:3729-3736, 2008.

73. Allen, J.D., Jaffer, Z.M., Burgin, S., Hofmann, C., Sells, M.A., Derr-Yellin, E., Michels, E.G., Bessler, W.K., Ingram, D.A., Chernoff, J.*, and Clapp, D.W.* p21-activated kinase 1 is required in mast cells for FcεRI-mediated inflammatory responses. Blood. 113:2695-2705, 2009. *co-corresponding authors. (Allen and Jaffer, co-first authors, Chernoff and Clapp co-senior authors).

74. Van den Broeke, C., Radu, M., Deruelle, M., Nauwynck, H., Hofmann, C., Jaffer, Z.M., Chernoff, J. and Favoreel, H.W. Alpha-herpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by p21-activated kinases 1 and 2. Proc. Natl. Acad. Sci. 106:8707-8712, 2009.

75. Arias-Romero, L.E., Saha, S., Villamar, O., Yip, S.-C., Ethier, S.P., Zhang, Z-Y., and Chernoff, J. Activation of Src by Protein Tyrosine Phosphatase (PTP)1B is required for ErbB2 transformation of breast epithelial cells. Cancer Res. 69:4582-4588, 2009.

76. Flaiz, C., Chernoff, J. Ammoun, S., Peterson, J.R., and Hanemann, C.R. PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp. Neurology 218:137-144, 2009.

77. Lightcap, C.M., Kari, G., Arias-Romero, L.E., Chernoff, J., Rodeck, U., and Williams, J.C. Interaction with LC8 Is required for Pak1 nuclear import and is indispensable for Zebrafish development. PLoS ONE 4:e6025, 2009.

78. Menges, C., Chen, Y., Mossman, B., Chernoff, J., Yeung, A., and Testa, J.R. A Phosphotyrosine proteomic screen identifies multiple tyrosine kinase signaling pathways aberrantly activated in Malignant Mesothelioma. Genes & Cancer 1:493-505, 2010.

79. Arias-Romero, L., Villamar-Cruz, O., Pacheco, A., Kosoff, R., Huang, M., Muthuswamy,

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S., and Chernoff, J. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene 29:5839-5849, 2010.

80. Molli, P.R., Li, D.Q., Bagheri-Yarmand, R., Pakala, S.B., Katayama, H., Sen, S., Iyer, J., Chernoff, J., Tsai, M.Y., Nair, S.S., and Kumar, R. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J. Cell Biol. 190:101-114, 2010.

81. Chow, H.-Y., Stepanova, D., Koch, J., and Chernoff, J. p21-activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2. PLoS ONE 5:e13791, 2010. doi:10.1371/ journal.pone.0013791.

82. Makhlin, I., Zhang, J., Chernoff, J., and Boorjian, S. The mTOR pathway impacts proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. Brit. J. Urol. 108:E84-90, 2011.

83. Van den Broeke, C., Radu, M., Nauwynck, H.J., Chernoff, J., Favoreel, H.W. Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase. Virus Res. 155:376-380, 2011.

84. De La Mota-Peynado, A., Chernoff, J, and Beeser A. Identification of the atypical extracellular regulated kinase 3 (Erk3) as a novel substrate for p21-activated kinase (Pak) activity. J. Biol. Chem. 286:13603-13611, 2011.

85. Shepelev, M.V., Chernoff, J., and Korobko, I. Rho Family GTPase Chp/RhoV induces PC12 apoptotic cell Death via JNK activation. Small GTPases 2:17-26, 2011.

86. Delorme-Walker, V.D., Peterson, J.R., Chernoff, J., Waterman, C.M., Danuser, G., Dermardirossian, C., Bokoch, G.M. Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J. Cell Biol. 193:1289-1303, 2011. Recommended at F1000 Prime (http://f1000.com/prime/13013958)

87. Sela, M., Bogin, Y., Beach, D., Oellerich, T., Lehne, J., Smith-Garvin, J., Okumura, M., Starosvetsky, E., Kosoff, R., Libman, E., Koretzky, G.A., Kambayashi, T., Urlaub, H., Wienands, J., Chernoff, J., and Yablonski, D. Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and Mast cells. EMBO J. 30:3160-3172, 2011.

88. Li, A., Ma, Y., Mort, R.L., Lindsay, C., Stevenson, D., Strathdee, D., Insall, R.H., Chernoff, J., Snapper, S.B. Jackson, I.J., Larue, L., Sansom, O.J., and Machesky, L.M. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod-driven motility and cell cycle progression. Dev. Cell 21:722-734, 2011.

89. Wang, X., Oh, E., Clapp, D.W., Chernoff, J., and Thurmond,, D.C. Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. J. Biol. Chem. 286:41359-41367, 2011.

90. Taglieri, D.M., Monasky, M.M., Knezevic, I, Sheehan, K.A., Lei, M., Wang X., Chernoff, J., Wolska, B.M., Ke, Y., and Solaro, R.J. Ablation of p21-activated kinase in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2. J. Mol. Cell Cardiol. 51:988-996, 2011.

91. Yip, S.C., Cotteret, S., and Chernoff, J. Sumoylated Protein Tyrosine Phosphatase (PTP)1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin. J. Cell Sci. 125:310-316, 2012.

92. Monasky, M.M., Taglieri, D.M., Patel, B.G., Chernoff, J., Wolska, B.M., Ke, Y., and Solaro, R.J. p21-activated kinase improves myocardial performance during ischemia/reperfusion injury by modulation of Troponin-T and Myosin Light Chain 2

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phosphorylation. Am. J. Physiol. 302:H224-230, 2012. 93. Hoover, W.C., Zhang, W., Xue, Z., Gao, H., Chernoff, J., Clapp, D.W., Gunst, S.J., and

Tepper, R.S. Inhibition of p21-activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. PLoS One 7:e42601, 2012.

94. Jhaveri, K.A., Debnath, P., Chernoff, J., Sanders, J., and Schwartz, M.A. The role of p21-activated kinase in the initiation of atherosclerosis. BMC Cardiovascular Disorders 12:55-62, 2012.

95. Menges, C.W., Sementino, E., Talarchek, J., Xu, J., Chernoff, J., Peterson, J.R., and Testa, J.R. Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Mol. Cancer Res. 10:1178-1188, 2012.

96. Chow, H.Y., Jubb, A.M., Koch, J.N., Jaffer, Z.M., Stepanova, D., Campbell, D.A., Duron, S. G., O'Farrell, M., Cai, Q., Klein-Szanto, A.J., Gutkind, J.S., Hoeflich, K.P., and Chernoff, J. p21-activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res. 72:5966-5975, 2012.

97. Chiang, Y.A., Shao, W., Chernoff, J., and Jin, T. p21-activated protein kinase 1 (Pak1) mediates the crosstalk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis. Endocrinology 154:77-88, 2013.

98. Kosoff, R., Chow, H.Y., Radu, M., and Chernoff, J. Pak2 restrains mast cell FcεRI-signaling through modulation of Rho GEF activity. J. Biol. Chem. 288:974-983, 2013.

99. Radu, M. and Chernoff, J. An in vivo assay to test blood vessel permeability. J. Vis. Exp. 16:e50062, 2013.

100. Dorrance, A.M., De Vita, S., Radu, M., Reddy, P.N.G., McGuinness, M.K., Harris, C.E., Mathieu, R., Lane, S.W., Kosoff, R., Milsom, M.D., Chernoff, J.,* and Williams, D.A. * The Rac GTPase effector p21 Activated Kinase-2 is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood 121:2474-82, 2013 *(co-senior authors)

101. Huynh, N., Yim, M., Chernoff, J., Shulkes, A., Baldwin, G.S., and He, H. p21-activated kinase 1 mediates gastrin-stimulated proliferation of the colorectal mucosa via multiple signalling pathways. Am J Physiol. Gastrointest. Liver Physiol. 304:G561-7, 2013.

102. Rawat, S., Creasy, C.L., Peterson, J., and Chernoff, J. The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylating and inactivating peroxiredoxin-1. J. Biol. Chem. 288:8762-71, 2013.

103. Arias-Romero, L. E., Villamar-Cruz, O., Huang, M., Hoeflich, K.P., and Chernoff, J. p21-activated kinase-1 links ErbB2 to β-catenin in transformation of breast epithelial cells. Cancer Res., 73:3671-82, 2013.

104. Aslan, J., Itakura, A., Haley, K., Tormoen, G., Loren, C., Baker, S., Pang, J., Chernoff, J., and McCarty, O.J.T. PAK signaling coordinates GPVI-mediated platelet aggregation, lamellipodia formation and aggregate stability under shear. Arterioscler. Throm. Vasc. Biol. 33:1544-51, 2013.

105. Aslan, J.E., Baker, S.M., Loren, C.P., Haley, K.M., Itakura, A., Pang, J., Greenberg, D.L., David, L.L., Chernoff, J., Manser, E., and McCarty, O.J.T. The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. Am. J. Physiol. Cell Physiol. 305:C519-28, 2013.

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106. Radu, M., Rawat, S.J., Beeser, A. and Chernoff, J. ArhGAP15, a Rac-specific GTPase Activating Protein, plays a dual role in inhibiting small GTPase signaling. J. Biol. Chem. 288:21117-25. 2013.

107. Itakura A., Aslan, J.E., Kusanto, B.T., Phillips, K.G., Porter, J.E., Newton, P.K., Nan, X., Insall, R.H, Chernoff, J., and McCarty O.J. p21-activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS One 8:e73063, 2013.

108. Licciulli, S., Maksimoska, J., Zhou, C., Troutman, S., Kota, S., Lin, Q., Duron, S., Campbell, D., Chernoff, J., Field, J., Mamorstein, R., and Kissil, J.L. FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of NF2-associated schwannomas. J. Biol. Chem. 288:29105-14, 2013.

109. Chiang, Y.A., Ip, W., Shao, W., Song, Z.E., Chernoff, J., and Jin, T. Activation of GLP-1 signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice. Endocrinology 155:2122-32, 2014.

110. Kelly, M.L., Astsaturov, A., Rhodes, J., and Chernoff, J. A Pak1/Erk signaling circuit acts through Gata6 to regulate cardiovascular development in zebrafish. Dev. Cell 29:350-9, 2014.

111. Phee, H., Au-Yeung, B.B., Pryshchep, O., O'Hagan, K.L., Fairbairn, S.G., Radu, M., Kosoff, R., Mollenauer, M., Cheng, D., Chernoff, J., and Weiss, A. Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. Elife 3:e02270, 2014.

112. Elsherif, L., Ozler, M., Zayed, M.A., Shen, J.H., Chernoff, J., Faber, J.E., and Parise, L.V. Potential compensation among group I PAK members in hindlimb ischemia and wound healing. PLoS One 9:e112239, 2014.

113. Badolia, R., Manne, B.K., Dangelmaier, C., Chernoff, J., and Kunapuli, S.P. Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets. Blood 125:175-84, 2015.

114. Zeng, Y., Broxmeyer, H.E., Staser, K., Chitteti, B.R., Park, S.J., Hahn, S., Cooper, S., Sun, Z., Jiang, L., Yang, X., Yuan, J., Kosoff, R., Sandusky, G., Srour E.F., Chernoff J., and Clapp D.W. Pak2 regulates hematopoietic progenitor cell proliferation, survival and differentiation. Stem Cells 33:1630-41, 2015.

115. Chow, H.Y., Dong, B., Duron, S.G., Campbell, D., Ong, C.C., Hoeflich, K.P., Chang, L.S., Welling, D.B., Yang, Z.j., and Chernoff, J. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget 10:1981-1994, 2015.

116. Ong, C.C., Gierke, S., Pitt, C., Sagolla, M., Cheng, C.K., Zhou, W., Jubb, A.M., Strickland, L., Schmidt, M., Duron, S.G., Campbell, D.A., Zheng, W., Dehdashti, S., Shen, M., Yang, N., Behnke, M.L., Huang, W., McKew, J.C., Chernoff, J., Forrest, W., Haverty, P.M., Chin, S.-F., Rakha, E.A., Green, A.R., Ellis, I.O., Caldas, C., O’Brien, T., Friedman, L.S., Koeppen, H., Rudolph, J., and Hoeflich, K.P. Small molecule inhibition of group I PAKs in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents. Breast Cancer Res. 17:59, 2015.

117. Singh, N. K., Kotla, S., Dyukova, E., Traylor, J.G. Jr. Orr, A.W., Chernoff, J. Marion, T.N., Rao, G.N. Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice. Nat. Comm. 6:7450, 2015.

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118. O'Hagan, K.L., Choi, J., Pryshchep, O., Chernoff, J., and Phee, H. Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance, J. Immunol. 195:1564-1577, 2015.

119. Kosoff,, R.E., Aslan, J.E., Kostyak, J.C., Dulaimi, E., Chow, H.-Y., Prudnikova, T.Y., Radu, M., Kunapuli, S.P., McCarty, O.J.T., and Chernoff, J. Pak2 restrains endomitosis during megakaryopoiesis. Blood 125:2995-3005, 2015.

120. Pandolfi, A., Stanley, R.F., Bartholdy, B., Pendurti, G., Gritsman, K., Boultwood, J., Chernoff, JH., Verma, A., and Steidl, U. PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. Blood 126:1118-1127, 2015.

121. Radu, M., Lyle, K., Hoeflich, K.P., Villamar-Cruz, O., Koeppen, H., and Chernoff, J. p21-activated kinase 2 (Pak2) regulates endothelial development and function through Bmk1/Erk5 pathway. Mol. Cell. Biol. 35:3990-2005, 2015 (cover story).

122. Prudnikova, T,Y., Villamar-Cruz, O., Rawat, S.J., Cai, K.Q., and Chernoff J. Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells. Oncogene 35:2178-2185, 2016.

123. Reddy, P.N.G., Radu, M., Xu, K., Wood, J., Harris, C.E., Chernoff, J., and Williams, D.A. p21 activated kinase 2 regulates HSC cytoskeleton, migration and homing via CDC42 activation and interaction with b-Pix. Blood, 127:1967-1975, 2016.

124. Rawat, S.J., Araiza-Olivera, D., Arias-Romero, L.E., Villamar-Cruz, O., Prudnikova, T.Y., Roder, H., and Chernoff, J. H-ras inhibits the hippo pathway by promoting Mst1/Mst2 heterodimerization. Curr. Biol. 26:1556–1563, 2016. (Featured as “Editor’s Choice,” Sci. Signaling 9:ec154, 2016; Recommended at F1000 Prime (http://f1000.com/prime/726388214).

125. Kurimchak, A.M., Shelton, C., Duncan, K.E., Johnson, K., Brown, J., Shane O’Brien, S., Gabbasov, R., Fink, L., Li, Y.S., Childers, W.E., Connolly, D.C., Chernoff, J., Peterson, J.R. and Duncan, J.S. Adaptation of the kinome promotes resistance to BET bromodomain inhibitors in ovarian cancer. Cell Rep. 16:1273-1286, 2016 (Featured as “Research Highlight,” Nature Rev. Clin. Oncol. 19 Aug 2016; doi:10.1038/nrclinonc.2016.130).

126. Hu, B., Arpag, S., Zhang, X., Mobius, W., Werner, H., Sosinsky, G., Ellisman, M., Zhang, Y., Hamilton, A., Chernoff, J., and Li, J. Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP. PLoS Genet. 12:e1006290, 2016.

127. Villamar-Cruz, O., Prudnikova, T., Araiza-Olivera, D., Pérez-Plasencia, C., Johnson, N., Bernhardy, A., Slifker, M., Renner, C., Chernoff, J., and Arias-Romero, L. Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition, Oncotarget 7:76590-76603, 2016.

128. Prudnikova, T. and Chernoff, J. The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin. Small GTPases, 8:193-198, 2017.

129. Joseph, G.A., Lu, M., Radu, M., Lee, J., Burden, S.J., Chernoff, J., and Krauss, R.S. Group I Paks promote skeletal myoblast differentiation in vivo and in vitro. Mol. Cell. Biol. 37: e00222-16, 2017.

130. Semenova, G., Stepanova, D., Deyev, S.M., and Chernoff, J. Medium throughput biochemical compound screening identified novel agents for pharmacotherapy of

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neurofibromatosis type I. Biochimie 135:1-5, 2017. 131. Semenova, G., Stepanova, D., Dubyk, C., Handorf, E., Deyev, S.M., Lazar, A.J., and

Chernoff, J. Targeting Group I p21-activated kinases to control tumor growth and metastasis in malignant peripheral nerve sheath tumors. Oncogene 36:5421-5431, 2017.

132. Stepanova, D.S., Semenova, G., Kuo, Y.-M., Andrews, A.J., Ammoun, S., Hanemann, C.O., and Chernoff, J. A novel function of the tumor suppressor gene NF2: Merlin controls fatty acid synthesis levels. Cancer Res. 77:5026-5038, 2017.

133. Tan, Y., Sementino, E., Chernoff, J., and Testa, J.R. Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity. Am. J. Cancer Res. 7:1724-1737, 2017.

134. Lu, H., Liu, S., Zhang, G., Wu, B., Zhu, Y., Frederick, D.T., Hu, Y., Zhong, W., Randell, S., Sadek, N., Zhang, W., Chen, G., Cheng, C., Zeng, J., Wu, L.W., Zhang, J., Liu, X., Xu, W., Krepler, C., Sproesser, K., Xiao, M., Miao, B., Liu, J., Song, C.D., Liu, J.Y., Karakousis, G.C., Schuchter, L.M., Lu, Y., Mills, G., Cong, Y., Chernoff, J., Guo, J., Boland, G.M., Sullivan, R.J., Wei, Z., Field, J., Amaravadi, R.K., Flaherty, K.T., Herlyn, M., Xu, X., and Guo, W. PAK signaling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature 550:133-136, 2017. (N.B., author correction published Nature, 2019, 565(7738):E4. doi: 10.1038/s41586-018-0814-7)

135. Zeng, K., Tian, L., Sirek, A., Shao, W., Liu, L., Chiang, Y.T., Chernoff, J., Ng, D.S., Weng, J., and Jin, T. Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression. J. Mol. Cell Biol. 9:384-394, 2017.

136. Zeng, Y., Hahn, S., Stokes, J.L., Hoffman, E.A., Chernoff, J., and Katsanis, E. Pak2 regulates myeloid derived suppressor cell development in mice. Blood Adv. 1:1923-1933, 2017.

137. Araiza-Olivera, D., Feng, Y., Semenova, G., Prudnikova, T., Rhodes, J., and Chernoff, J. Suppression of RAC1-driven malignant melanoma by Group A PAK inhibitors. Oncogene 37:944-952, 2018.

138. Kim, S., Ravi, A., Nguyen, T., Kubiniok, P., Finicle, B., Malacrida, L., Hou, J., Jayashankar, V., Robertson, J., Chernoff, J., Digman, M., Potma, E., Tromberg, B., Thibault, P., and Edinger, A. PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells. Cancer Discovery 8:866-883, 2018.

139. Chow, H.Y., Dong, B., Valencia, C.A., Zeng, C.T., Koch, J.N., Prudnikova, T.Y. and Chernoff, J. Group I Paks are essential for epithelial-mesenchymal transition in an Apc-driven model of colorectal cancer. Nature Comm. 9:3437, 2018.

140. Karchugina, S. and Chernoff, J. Detection of heterodimerization of protein isoforms using an in situ proximity ligation assay. J. Vis. Exp. doi:10.3791/57755, 2018.

141. Wang, X., Binder, P., Wang, S., Radu, M., Zi, M., Collins, L., Khan, S., Li, Y., Sekeres, K., Humphreys, N., Swanton, E., Reid, A., Oceandy, D., Guan, K., Hille, S., Frey, N., M‹ ller, O., Cartwright, E., Chernoff, J., and Liu, W. Pak2 as a novel therapeutic target for cardioprotective endoplasmic reticulum stress response. Circ. Res. 124:696-711, 2019.

142. Kurimchak, A. M., Brown, J., Johnson, K.J., Duncan, K.E., Srivastava, N., Kumar, V., Deihimi, S., Peri, S., Mantia-Smaldone, G.M., Jain, A., Winters, R.M., Sodi, V., O’Brien, S., Zuercher, W.J., Cai, Q., Connolly, D.C., Chernoff, J., Duncan, J.S. Proteogenomic

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interrogation of the kinome identifies MRCKA an integral component of ovarian cancer signaling and emerging therapeutic target. Cell Rep. (in press).

143. Korobeynikov, V., Borakove, M., Feng, Y., Wuest, W.M., Koval, A., Nikonova, A.N., Serebriiskii, I., Chernoff, J., Borges, V.F., Golemis, E.A., Shagisultanova, E. Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer. Breast Cancer Res. Treat. (in press).

144. Kurimchak, A., Shelton, C., Duncan, K., Chernoff, J., Herrera-Montávez, Duncan J. Intrinsic Resistance to MEK to MEK Inhibition Through BET protein mediated kinome reprogramming in NF1-deficient ovarian cancer. Mol. Cancer Res. (in press)

Chapters, Editorials, and Reviews: 1. Chernoff, J., Schievella, A.R., and Neel, B.G. Molecular cloning and expression of a major

human protein tyrosine phosphatase. Adv. Protein Phosphatases 6:59-71, 1991. 2. Sells, M.A. and Chernoff, J. Polymerase chain reaction cloning of related genes. Meth.

Enzymol. 254:184-195, 1995. 3. Sells, M.A. and Chernoff, J. Emerging from the Pak: the p21-activated protein kinase

family. Trends Cell Biol. 7:162-167, 1997. 4. Chernoff, J. Protein tyrosine phosphatases as negative regulators of mitogenic signaling. J.

Cell. Physiol. 180:173-181, 1999. 5. Chernoff, J. Close encounters of the LIM kinase. Nature Cell Biol. 1:E115-117, 1999. 6. Valster, A.H., Hepler, P.K., and Chernoff J. Plant GTPases: the Rhos in bloom. Trends

Cell Biol, 10:141-146, 2000. 7. Chernoff, J. Mitogenic signal transduction, in Basic Science of Cancer, Current Medicine

(Kruh, G.D and Tew, K.D., eds) 75-92, 2000. 8. Serebriiskii, I.G., Mitina, O.V., Chernoff, J., and Golemis, E.A. Use of a two-hybrid dual

bait system to discriminate specificity of protein interactions in small GTPases. Meth. Enzymol. 332:277-300, 2001.

9. Cotteret, S. and Chernoff, J. The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biology 3: 0002.1-0002.8, 2002. (cover story)

10. Chernoff, J. Signal Transduction and Mammalian Cell Growth, in Protein-Protein Interactions: A Molecular Cloning Manual, CSHL Press (Golemis, E.A., ed) 7-13, 2002.

11. Jaffer, Z and Chernoff, J. p21-activated kinases: three more join the Pak. Int J. Biochem. & Cell Biol. 34:713-717, 2002.

12. Nikolic, M. and Chernoff, J. High midsummer for Rho GTPases. Trends Cell Biol. 12:495-497, 2002.

13. Dadke, S. and Chernoff, J. Protein-Tyrosine Phosphatase 1B as a potential drug target for obesity. Curr. Drug Targets – Immune, Endocr. & Metabol. Disord. 3:243-248, 2003.

14. Beeser, A and Chernoff, J. Rho GTPases and Cell Motility, in Rho GTPases, Landes Biosciences publs (Symons, M., ed) 141-154, 2003. ISBN: 1-58706-199-6, epub http://eurekah.com/chapter.php?chapid=1384&bookid=104&catid=56.

15. Valster, A.H., Hepler, P.K., and Chernoff, J. Rho GTPases in plants, in Rho GTPases, Landes Biosciences publs (Symons, M., ed) 219-229, 2003. ISBN: 1-58706-199-6, epub http://www.eurekah.com/abstract.php?chapid=1333&bookid=104&catid=56.

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16. Xiao, G.-H., Chernoff, J,. and Testa, J.R. NF2: The wizardry of Merlin. Genes Chrom. Cancer 38:389-399, 2003.

17. Jaffer, Z. and Chernoff, J. The cross Rho’ds of cell-cell adhesion. J. Biol. Chem. 279:35123-35126, 2004.

18. Hofmann, C., Shepelev, M., and Chernoff, J. The genetics of Pak. J. Cell. Sci. 117:4343-4354, 2004.

19. Sorokina, E. and Chernoff, J. Rho GTPases: new members, new pathways. J. Cell. Biochem. 94:225-231, 2005.

20. Golemis, E.A. and Chernoff, J. Editorial: Analysis and manipulation of intracellular signaling cascades. Methods, 32/4:347-348, 2005.

21. Chernoff J. STK4 (serine/threonine kinase 4). Atlas Genet. Cytogenet. Oncol. Haematol. November 2005. URL: http://AtlasGeneticsOncology.org/Genes/STK4ID42440ch20q11.html

22. Cotteret, S. and Chernoff, J. Pak GITs to Aurora A. Dev. Cell. 9:1–2, 2005. 23. Beeser, A and Chernoff, J. Production and use of a cell permeable inhibitor of group A

Paks (TAT-PID) to analyze signal transduction. Methods 37:203-207, 2005. 24. Peterson, J.R. and Chernoff, J. Src transforms in a Cool way. Nat. Cell Biol. 8:905-907,

2006. 25. Chernoff, J. Pak5. UCSD-Nature Molecule Pages (2007). (doi:10.1038/mp.a000829.01). 26. Chernoff, J. PTP1B. UCSD-Nature Molecule Pages (2008). (doi:10.1038/mp.a000088.01). 27. Chernoff, J. Mst1. UCSD-Nature Molecule Pages (2008). (doi:10.1038/mp.a001348.01). 28. Chernoff, J. Mst2. UCSD-Nature Molecule Pages (2008). (doi:10.1038/mp.a001347.01). 29. Stepanova, D. and Chernoff J. PAK1 (p21/Cdc42/Rac1-activated kinase 1 (STE20

homolog, yeast)). Atlas Genet Cytogenet Oncol Haematol. December 2007. 30. URL: http://AtlasGeneticsOncology.org/Genes/PAK1ID41633ch11q13.html 31. Arias-Romero L.E. and Chernoff, J. A tale of two Paks. Biology of the Cell 100:97-108,

2008. 32. Radu, M. and Chernoff, J. The deMSTification of Mammalian Sterile-20 Kinases. Curr.

Biol. 19:R421-R425, 2009. 33. Pacheco, A. and Chernoff, J. Group I p21-Activated kinases: emerging roles in immune

function and viral pathogenesis. Int J. Biochem. & Cell Biol. 42:13-16, 2010. 34. Van den Broeke, C., Radu, M., Chernoff, J., and Favoreel, H. An emerging role for p21-

activated kinases (Paks) in viral infections. Trends Cell Biol. 20:160-169, 2010. 35. Cerione, R., Chernoff, J., Kahn, R.A., Knaus, U. Gary M. Bokoch (1954–2010), Dev. Cell

18: 357-358, 2010. 36. Yip, S.C., Saha, S., and Chernoff, J. Protein Tyrosine Phosphatase 1B: a cellular double

agent in metabolism and oncogenesis. Trends Biochem. 35:442-449, 2010. 37. Kosoff, R. and Chernoff, J. LOV conquers (sm)all GTPases. F1000 Biology Reports, 2:28

doi:10.3410/B2-28, 2010.

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38. Arias-Romero, L. and Chernoff, J. p21-activated kinases in ErbB2-positive breast cancer: a new therapeutic target? Small GTPases 1:124-128, 2010.

39. Huson, S.M., Acosta, M.T., Belzberg, A., Bernards, A., Chernoff, J., Cichowski, K., Evans, D.G., Ferner, R.E., Giovannini, M., Korf, B., Listernick, R., North, K., Packer, R., Parada, L.F., Peltonen, J., Ramesh, V., Reilly, K., Schorry, E., Uphadyaya, M., Viskochil, D., Zhu, Y., Hunter-Schaedle, K., Giancotti, F. Conference Report: Back to the Future: Proceedings from the 2010 NF Conference. Am. J Med. Gen. 155:307-321, 2010.

40. Arias-Romero, L.E. and Chernoff J. p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target? Small GTPases 1:124-128, 2010.

41. Kelly, M.L. and Chernoff, J. Getting smart about p21-activated kinases. Mol. Cell Biol. 31:386-387, 2011.

42. Semenova, G. and Chernoff, J. PKM2 enters the morpheein academy. Mol. Cell. 45:583-584, 2012.

43. Kelly, M.L. and Chernoff, J. Mouse models of Pak function. Cell Logist. 2:84-88, 2012. 44. Kelly, M.L., Astsaturov, A., and Chernoff, J. Role of p21-activated kinases in

cardiovascular development and function. Cell Mol Life Sci 70:4223-4228, 2013. 45. Arias-Romero, L.E. and Chernoff, J. Targeting Cdc42 in cancer. Exp Op. Ther. Targ.

17:1263, 2013. 46. Hoeflich, K.P., Rudolph, J., Crawford, J., and Chernoff, J. Small molecule inhibitors of Pak.

The Enzymes 34:157-180, 2013.

47. Saha, S. and Chernoff, J. Analysis of PTP1B sumoylation. Methods, 65:201-206, 2014. 48. Radu, M., Semenova, G., Kosoff, R., and Chernoff, J. PAK signalling during the

development and progression of cancer. Nat. Rev. Cancer 14:13-25, 2014. 49. Baker, N.M., Yee Chow, H., Chernoff, J, and Der, C.J. Molecular pathways: targeting

RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers. Clin. Cancer Res. 20:4740-6. 2014.

50. Prudnikova, T.Y., Rawat, S.J., and Chernoff, J. Molecular pathways: targeting the kinase effectors of RHO-family GTPases. Clin. Cancer Res. 21:24-9, 2015.

51. Rawat, S.J. and Chernoff, J. Regulation of mammalian Ste20 (Mst) kinases. Trends Biochem. Sci. 40:149-56, 2015.

52. Does salmon calcitonin cause cancer: a review and meta-analysis. Wells, G., Chernoff, J., Gilligan J.P., and Krause, D.S. Osteoporos. Int. 27:13-9, 2016.

53. Chernoff, J. Rac1. Cancer Therapeutic Targets (Springer New York, J.L. Marshall ed.) 1-5, 2016, doi:10.1007/978-1-4614-6613-0_24-2.

54. Bellacosa, A., Chernoff, J., and Testa, J.R. Alfred G. Knudson (1922–2016), Cell 166: 785-786, 2016.

55. Araiza-Olivera, D. and Chernoff, J. Hras helps Hippo heterodimerize to evade tumor suppression, Small GTPases, doi: 10.1080/21541248.2016.1228794, 2016.

56. Semenova, G. and Chernoff, J. Targeting PAK1. Biochem. Soc. Trans. 45:79-88, 2017. 57. Chernoff, J. Alfred G. Knudson: in Memorium (1922-2106). Cancer Res. 77:815-816, 2017.

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58. Radu, M. and Chernoff, J. Recent advances in methods to assess the activity of the kinome. F1000Research, 6:1004, 2017.

59. Stepanova, D.S. and Chernoff, J. A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis, Oncoscience 5:126-127, 2018.

60. Chernoff, J. How to get and keep your lab funded. Mol. Biol. Cell 29:2519-2521, 2018. Editorial Projects: Golemis E.A. and Chernoff, J. Editors, Analysis and Manipulation of Intracellular Signaling Cascades. Methods, 32/4:347-348. Seminars (unrecorded prior to 1996) 3/96 Clinical Research Institute of Montreal, Canada 4/96 Merck, West Point, PA 6/96 University of Pennsylvania, Philadelphia, PA 10/96 Harvard Medical School, Boston, MA 10/96 Washington University, St Louis, MO 12/96 University of Pennsylvania, Philadelphia, PA 5/97 Cold Spring Harbor meeting on Tyrosine Phosphorylation. Invited Speaker 7/97 Marine Biology Lab, Woods Hole, MA 7/97 Astra Zeneca 10/97 Wistar Institute, Philadelphia, PA 1/98 Merck, West Point, PA 5/98 Johns Hopkins Medical School, Baltimore, MD 6/98 Massachusetts General Hospital Cancer Center, Boston, MA 7/98 Marine Biology Lab, Woods Hole, MA 8/98 Salk Institute meeting on Tyrosine Phosphorylation. Invited Speaker 10/98 University of Massachusetts, Amherst (Invited by Graduate Students) 11/98 Indiana University School of Medicine (Invited by Graduate Students) 11/98 Medical Research Institute, Indianapolis, IN 12/98 Albert Einstein College of Medicine, NY, NY 1/99 Institute of Molecular Genetics, Prague, Czech Republic 2/99 National Cancer Institute, Bethesda, MD 2/99 Astra Zeneca 3/99 FASEB Small GTPases, Santé Fe, NM. Invited Speaker 4/99 M.D. Anderson, Houston, TX 5/99 Onyx Pharmaceuticals, CA 7/99 Englehart Conference, Moscow, Russia. Invited Speaker 7/99 FASEB: Protein Kinases and Phosphorylation, Snowmass CO. Invited Speaker 11/99 Harvard Medical School, Boston, MA 2/00 MCP Hahnemann, Philadelphia, PA 4/00 The Picower Institute, NY 5/00 Medical College of Wisconsin, Milwaukee, WI 5/00 Onyx Pharmaceuticals, CA 5/00 Netherlands Cancer Institute, Amsterdam, Netherlands 5/00 Ludwig Institute for Cancer Research, London, UK 5/00 Aventis Pharmaceuticals, Munich, Germany

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7/00 FASEB: The Ras Superfamily of Small GTP-binding Proteins, Snowmass CO. Invited Speaker

3/01 Albert Einstein College of Medicine, NY, NY 4/01 Indiana University, Indianapolis, IN 4/01 University of North Carolina, , Chapel Hill, NC 4/01 Morphochem Inc., Princeton, NJ 5/01 Sugen, Inc., S. San Francisco, CA 7/01 Ben Gurion University, Beer Sheva, Israel 8/01 Gordon Conference: Mechanisms of Cell Signalling, Oxford UK. Invited speaker 8/01 Karolinska Institute, Huddinge, Sweden 11/01 University of North Carolina, Chapel Hill, NC 3/02 Mount Sinai School of Medicine, NY, NY 4/02 University Medical and Dental College of New Jersey, Newark, NJ 5/02 University of California, Los Angeles, CA 7/02 FASEB: Small G Protein Networks in Cell Dynamics, Snowmass CO. Invited

Speaker 10/02 Stony Brook, NY 10/02 Long Island Jewish Hospital, NY 10/02 Cold Spring Harbor Laboratories, NY 6/03 Gordon Conference: Mechanisms of Cell Signaling, Ventura, CA. Invited speaker 9/03 Mt. Sinai School of Medicine; MD. Ph.D. retreat 12/03 University of Cincinnati, Cincinnati, OH 2/04 Mt. Sinai School of Medicine; MD. Ph.D. dinner, NY, NY 4/04 University of Florida, Tampa, FL 7/04 FASEB: Small G Protein Networks in Cell Dynamics, Snowmass CO. Invited

Speaker 11/04 Columbia University, NY, NY 12/04 Roswell Park Cancer Institute, Buffalo, NY 2/05 University of Pennsylvania, Philadelphia, PA 4/05 New York University, NY, NY 6/05 Gordon Conference: Mechanisms of Cell Signaling, Hong Kong, China. Vice-Chair 9/05 University of Oklahoma, Oklahoma City, OK 11/05 Banbury Conference: Barriers & Solutions in the Use of Mouse Models to Develop

Therapeutic Strategies for NF1 and NF2 - Associated Tumors, Invited Speaker 12/05 Wayne State, Michigan, Detroit, MI 5/06 University of California, Riverside, CA 5/06 Scripps University, La Jolla, CA 5/06 University of South Dakota, Sioux Falls, SD 5/06 Wyeth Pharmaceuticals, Pearl River, NY 7/06 FASEB: Small G Protein Networks in Cell Dynamics, Saxtons River VT. Vice-Chair 10/06 University of Alberta, Edmonton, Canada 2/07 Ben Gurion University, Beer-Sheva, Israel, Dozer Lecturer 2/07 Tel Aviv University, Tel-Aviv, Israel 3/07 University of Virginia, Charlottesville, VA 9/07 Thomas Jefferson School of Medicine, Philadelphia, PA 9/07 University of Gent, Gent, Belgium 9/07 Gordon Conference: Mechanisms of Cell Signaling, Oxford, UK. Chair 9/07 Oxford University, Oxford, UK 10/07 Indiana University School of Medicine, Indianapolis, IN 11/07 University of Illinois School of Medicine, Chicago, IL

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4/08 Genentech, San Francisco, CA 5/08 Georgetown University, Washington, D.C. 5/08 University of Cincinnati, Cincinnati, OH 6/08 Weis Center for Research, Danville, PA 7/08 FASEB: Regulation and Function of Small GTPases, Saxtons River VT, Invited

Speaker 9/08 New York University, NY, NY 10/08 University of Pennsylvania, Philadelphia, PA 1/09 Novartis, Emeryville, CA 8/09 Gordon Conference: Mechanisms of Cell Signaling, Oxford, UK. Invited Speaker 10/09 Kansas State University, Manhattan, KS 10/09 Lankenau Institute for Medical Research 3/10 Novartis, Emeryville, CA 3/10 Genentech, San Francisco, CA 3/10 Case Western, Cleveland, OH 5/10 Mt Sinai School of Medicine, NY, NY 5/10 University of Virginia, Charlottesville, VA 5/10 American Asthma Foundation, San Francisco, CA 6/10 Neurofibromatosis Conference, Baltimore, MD. Session Chair 6/10 Russian Academy of Science conference: Control of Gene Expression, Moscow,

Russia. Session Chair 7/10 FASEB: Protein Kinases and Phosphorylation, Snowmass, CO. Invited Speaker 10/10 University of West Virginia, Morgantown, WV 05/11 Genentech, San Francisco, CA 06/11 FASEB: Regulation and Function of Small GTPases, Saxtons River, VT. Invited Speaker 11/11 Case Western, Cleveland, OH 2/12 Commonwealth Medical College, Scranton, PA 3/12 Memorial Sloan Kettering Cancer Center, NY, NY 5/12 Genentech, San Francisco, CA 6/12 Neurofibromatosis Conference, New Orleans, LA, Invited Speaker 6/12 Rutgers University School of Medicine, Piscataway, NJ 7/12 University of Utah, Provo, UT (two lectures) 9/12 University of North Carolina, Chapel Hill, NC 9/12 Duke University, Durham, NC 10/12 Temple University, Philadelphia, PA 12/12 McGill University, Montreal, Canada 1/13 Astra-Zeneca, Boston, MA 3/13 New York University, MD/PhD retreat, Stowe, VT Keynote Speaker 6/13 FASEB: Regulation and Function of Small GTPases, Snowmass, CO, Invited Speaker 7/13 Albert Einstein Medical School, NY, NY 9/13 National Cancer Institute of Mexico, Mexico City (two lectures), Distinguished

Speaker 11/13 PDDI Annual Drug Discovery Awards, Keynote Presentation, Doylestown, PA 12/13 Temple University, Sol Sherry Thrombosis Center, Philadelphia, PA 3/14 Perlmutter Cancer Center, NYU, NY, NY 4/14 AACR, San Diego, CA, Targeting Rho GTPases and Their Kinase Effectors,

Educational Session Chair 5/14 Ohio State Cancer Center, Columbus, OH

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5/14 University of Leuven, Leuven, Belgium 5/14 Karolinska Institute, Huddinge, Sweden 6/14 Neurofibromatosis Conference, Washington, DC, Invited Speaker 6/14 Biomedicine Research Unit (UBIMED), Mexico City, Mexico, Plenary Lecture 1/15 Oregon Health & Science University, Portland, OR 4/15 Temple University, Philadelphia, PA 6/15 FASEB: Regulation and Function of Small GTPases, Palm Beach, FL, Invited

Speaker 1/16 Medical University of South Carolina, Charleston, SC 2/16 Temple University School of Medicine, Administrative Forum, Philadelphia, PA 2/16 Yale University School of Medicine, New Haven, CT 3/16 Yale University School of Medicine, Grand Rounds, New Haven, CT 5/16 University of North Carolina, Chapel Hill, NC 9/16 Temple University School of Medicine, Translational Day Award lecture 2/17 University of Miami, Miami, FL 5/17 Frederick National Laboratory for Cancer Research, Frederick, MD 5/17 Puerto Rico INBRE and COBRE Scientific Symposium, San Juan, PR., Invited

Speaker 6/17 FASEB: Regulation and Function of Small GTPases, Palm Beach, FL, Invited

Speaker; Session Chair. 8/17 Albert Einstein Medical School, NY, NY 11/17 Sidney Kimmel Cancer Center, Thomas Jefferson, Grand Rounds, Philadelphia, PA 2/18 RISE program seminar, University of Puerto Rico, San Juan, PR. 4/18 UBIMED, UNAM, Mexico City, Mexico 4/18 Instituto de Química, UNAM, Mexico City, Mexico 7/18 Biochemical Society: Small G proteins in cellular signalling and disease, Cambridge,

UK; Invited Speaker 8/18 Coriell Institute, Camden, NJ 9/18 American Society for Biochemistry & Molecular Biology 2018, Frontiers in RAS

Pathobiology and Drug Discovery Special Symposium, Stratton, VT 3/19 UC Davis Cancer Center, Sacramento, CA 5/19 Fundación Ramón Areces: The RAS superfamily and related pathways in health and

disease, Santander, Spain