Joint Programming in Neurodegenerative Disease Research (JPND) · Joint Programming in...
Transcript of Joint Programming in Neurodegenerative Disease Research (JPND) · Joint Programming in...
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Joint Programming in Neurodegenerative Disease Research (JPND)
Coordinating approaches to research across Europe
Adriana MaggiVice-Chair, JPND Executive Board
26/10/2013
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A new Member States-led initiative in Europe which aims to address “grand challenges” to EU society by coordinating national research programmes within the EU to increase the impact and effectiveness of research efforts.
What is Joint Programming?
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COST OF DISORDERS OF THE BRAIN IN EUROPE
Estimates in 2004
Estimates in 2010
(1) Referred to as “effective disorders” in 2005, (2) includes only incident cases in 2010, (3) weighted mean from all countries and diagnoses(5) including also persons with zero costs, (6) excluding indirect costs, (7) excluding PTSD (European Neuropsychopharmacology (2011) 21, 718-779)
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A global health and economic emergency
• Between now and 2050, over 680 million new cases of dementia will be diagnosed worldwide 1
• That’s 680 million people living with dementia in the next 40 years! • more than the population of all of North America (542 million) and nearly as
much as all of Europe (738 million)
• ND are the most expensive of all known diseases• Global cost of dementia in 2010 is $604 billion - 1% of global GDP 2
• Current economic crisis is affecting research budgets
A global health and economic emergency
• Between now and 2050, over 680 million new cases of dementia will be diagnosed worldwide 1
• That’s 680 million people living with dementia in the next 40 years! • more than the population of all of North America (542 million) and nearly as
much as all of Europe (738 million)
• ND are the most expensive of all known diseases• Global cost of dementia in 2010 is $604 billion - 1% of global GDP 2
• Current economic crisis is affecting research budgets
1 – World Alzheimer Report 20122 – WHO Dementia Report 2012
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AN EPIDEMICS FOR NEURODEGENERATION?
INCREASING AGE
LACK OF THERAPIES!
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Impact of a 5-year delay on the onset by stage of
disease, Americans aged 65 and older with AD, 2050
Changing the trajectory
Proportion of American Age 65 and older with Azheimer Disease by Stage of Disease 2010-2050
What if we delay the onset and progression?
Cortesy M. Di Luca 2013
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JPND - The Pilot Project in Joint Programming
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We cannot tackle neurodegenerative diseases by acting as single countries
AlbaniaAustria
BelgiumCanadaCroatia
Czech RepublicDenmarkFinlandFrance
GermanyGreeceHungaryIrelandIsraelItaly
LuxembourgNetherlands
NorwayPoland
PortugalSlovakiaSlovenia
SpainSweden
SwitzerlandTurkey
United Kingdom
JPND is a global research initiative led by countries , with 27 member states, associated countries and third countries participating
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JPND is currently supportedby FP7-JUMPAHEAD (GA. 260774)
Management Board27 countries representedChair Philippe Amouyel (France)
Executive BoardVice-Chair Adriana Maggi (Italy)Rob Buckle (UK)Marlies.Dorloechter) (Germany)Mogens Horder (Denmark)
Scientific Advisory Board18 Members Chosen for scientific excellence and competence
Organisation
Steering CommitteeExecutive Board+Edvard Beem (The Netherlands) Enda Connolly (Ireland)Rainer Girgenrath (Germany)Nihan Eryilmaz (Turkey)
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DEFRAGMENTATION, THIS IS ALL WHAT JPND IS ABOUT
STRATEGIC RESEARCH AGENDA
ALIGNMENT OF EU COUNTRIESON COMMON RESEARCH GOALS
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The SRA goals
To tackle the challenge of Alzheimer’s and other neurodegenerative diseases*, the goals of the JPND Research Strategy are:
* Alzheimer’s disease and other dementias (AD), Parkinson’s disease (PD) and PD-related disorders, Prion disease, motor neurone diseases (MND), Huntington’s disease (HD), Spinocerebellar ataxia (SCA), Spinal muscular atrophy (SMA)
• To develop new treatments and preventive strategies
• To improve health and social care approaches
• To raise awareness and de-stigmatise neurodegenerative disorders
• To alleviate the economic and social burden of these diseases
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Implementation of the SRA
Launch calls aimed at harmonizing EU research in the field of Neurodegenerative Diseases
Organize working groups to create a list of opportunities suited for the SRA implementation
Stimulate the creation of national plans for dementia and aligne these programs
Identify strategies for the implementation of common infrastructures
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What are the conditions that create a ripe environment for innovation?
Joint Transnational Calls
One in 2011 for €16 M
Two in 2012-2013 for €29 M
Two in 2013-2014 for about € 30 M
Centres of Excellence in
Neurodegeneration (CoEN) program
2011 for € 6M ; in 2012-13 for € 8M
night science wanders blind. It hesitates, stumbles, recoils, sweats, wakes with a start. […] There is no way to predict whether night science will ever become day science; whether the prisoner will emerge from the darkness
«Of flies, mice and man» Francois Jacob
Conscious of its progress, proud of its past, sure of its future, day science advances in light and glory
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JPND Call for Proposals:
”European research projects for Cross-Disease Analysis of Pathways related to Neurodegenerative Diseases”
Submission deadline for proposals: 18th February 2014
•Canadian Institutes of Health Research•Finland, Academy of Finland •France, French National Research Agency•Germany, Federal Ministry of Education and Research •Italy
Ministry of Health Ministry of Education, Universities and Research
•Netherlands, The Netherlands Organisation for Health Research and Development •Norway, The Research Council of Norway •Poland, National Science Centre•Portugal, Foundation for Science and Technology•Slovakia, Ministry of Education, Science, Research and Sport of the Slovak Republic•Spain, National Institute of Health Carlos III•Sweden, Swedish Research Council •Turkey, Scientific and Technological Research Council of Turkey
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VALI
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DEFRAGMENTATION, THE JPND APPROACH
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Stimulate the creation of national plans for dementia and aligne these programs
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NATIONAL DEMENTIA PLANS
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“EC sees JPIs as Knowledge Hubs”
JPI e il programmaHorizon 2020
Robert Jan-Smith Direttore Generale DG Research and Innovationdell’European Commision
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……e a livello Nazionale?
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RAPPRESENTANTI ITALIANI NEL JPND
• Executive Board: Adriana Maggi, Unimi, Vice-chair
• Management Board: Maria Uccellatore, MIURFabrizio Tagliavini, IRCCS, Besta
• Comitato Scientifico: Stefano Cappa, IRCCS San Raffaele
• Action group: interazione con Industrie A.Maggi chair
• Action group: Experimental animals A.Maggi chair and F. Blandini, IRCCS Mondino
• Action group: Longitudinal cohorts S. Cappa
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Carlo Caltagirone, Roma Stefano Cappa, MilanoGiovanni Frisoni, BresciaAdriana Maggi, MilanoAlessandro Padovani, BresciaPaolo Maria Rossini, RomaFabrizio Tagliavini, Milano
Gaetano Guglielmi, Min SalMaria Uccellatore, MIUR
Il gruppo di supporto alle attività JPND
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Un piano nazionale per le demenze
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Un piano nazionale per le demenze
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……e a livello Nazionale?
le nostre preoccupazioni
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Italian excellence in the field of neurodegeneration
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IF medio delle ultime 30 pubblicazioniapparse in Pub Med (16/6/2012)
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EPOC-AD: EUROPEAN PLATFORM TO FACILITATE PROOF OF CONCEPT FOR PREVENTION IN
ALZHEIMER’S DISEASE
DRAFT PROPOSAL
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Biomarkers and adaptive trial design in AD; a proposal
Stratification markers
Progression markers
High specificity, high intervention markerse.g. CSF or PET markers of pathology
Best combination of markerse.g. slope measurement in as short a time frame as possible
High sensitivity, low intervention markerse.g. blood based markers discovered by targeted endophenotype design
Unbiased, data-driven discoverye.g. wide range of assessments; short assessment period
Thanks to Simon Lovestone (King’s College, UK)
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EPOC Proposal - DRAFT
• Let’s build a biomarker based GPS system to identify the position of subjects on their trajectory towards developing dementia
• To achieve this, let’s set up large scale longitudinal natural history study• Initially the study will learn about biomarker trajectories• Later the study may become a platform for
pharmacological intervention trials
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Keep up to date
• Visit the JPND website:• http://www.neurodegenerationresearch.eu• http://www.jpnd.eu
• Search our Mapping Database
• Sign up to the JPND News Feeds
• E-mail us: [email protected]
• Follow us on Twitter: @JPNDEurope
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The next Challenges
• To continue implementation beyond phase I
• To partner with European Commission
• To partner with Industry
• To ensure JPND sustainability
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Partnering with Industry
• Substantive participation in development of JPND Research Strategy
• Now Members of Scientific Advisory Board
• Ongoing discussions with EFPIA-IMI
• Enlarge the contacts (pharma, device, IT, diagnosis, imaging, welfare technologies, AAL, …)
• JPND Industry Action Group to develop new public-private-partnerships
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Societal NeedsSocietal Needs Creative research (Idea Generation)
Creative research (Idea Generation)
Innovation(Idea Implementation)
Innovation(Idea Implementation)
• 27 JPND Members
• Member States
• Assoc. Countries
• Third Countries
• Eur. Commission
• Industry
• Public and Users
• 27 JPND Members
• Member States
• Assoc. Countries
• Third Countries
• Eur. Commission
• Industry
• Public and Users
• Common Strategy
• Transnational Calls
• Alignment Actions
• National Plans
• Communication +
Dissemination
• Common Strategy
• Transnational Calls
• Alignment Actions
• National Plans
• Communication +
Dissemination
• New treatments +preventive strategies
• Improved health + social care approaches
• De-stigmatize ND• Alleviate economic and
social burden
• New treatments +preventive strategies
• Improved health + social care approaches
• De-stigmatize ND• Alleviate economic and
social burden
PARTNERSHIP ACTIONS OUTCOMES
JPND ResearchJPND Research
Basic Clinical Healthcare/SocialBasic Clinical Healthcare/Social