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USAJohnson Matthey2001 Nolte DriveWest Depford, NJ 08066Tel: +1 856 384 [email protected]

FranceJohnson Matthey SASZl Paris Nord 2, BP 5124095956 Roissy CGD, FranceTel: +33 1 48 17 21 [email protected]

UKJohnson MattheyOrchard Road, Royston, HertfordshireSG8 5HE UKTel: +44(0) 1763 [email protected]

IndiaJohnson Matthey Chemicals India Pvt LtdPlot No. 6A, MIDC Industrial EstateTaloja, Dist. Raigad, Maharashtra, 41020, IndiaTel: +91 22 2740 [email protected]

BeneluxJohnson Matthey SASPegasuslaan 51831 Diegem, BelguimTel: +32 2 [email protected]

ChinaJohnson Matthey (Shanghai)586 Dong Xing RoadSong Jiang Industrial Zone 201613, Shanghai, ChinaTel: +86 21 33528282 ext [email protected]

JapanJohnson Matthey JapanImperial Tower 14th Floor, 1-1-1 Uchisaiwai-cho, Chiyoda-kuTokyo 100-0011 JapanTel: +81 3 5511 [email protected]

IsraelN. Intrater & AssociatesP.O. Box 21016, 5, Lurie StreetTel-Aviv, Israel 61210Tel: +972 3 [email protected]

SpainC.J. Chamber Hispania, S.L.08840 VilladecansBarcelona 08840 SpainTel: +34 93 [email protected]

GermanyJohnson MattheyMerowingerplatz 1A40225 DüsseldorfTel: +49 172 66 12 [email protected]

Eastern EuropeD’Orland KEG Ltd.Liason O� ce, Tr. Kpt. Jarosse 6Brno, CZ-602 00 Brno, Czech RepublicTel: +4205 452 [email protected]

EsterasesFor Biocatalytic Resolution of Chiral Acids

Application:

• Stereoselective hydrolysis of esters

• Stereoselective esteri� cation of carboxylic acids

• Can be carried out in organic solvents or aqueous mixtures

• Mild conditions; tolerant of wide range of functionality

LipasesFor the Production of Enantiomerically Pure Amines and Alcohols

• Stereoselective acylation of amines

• Rapid access to both R and S stereoisomers

• Can be carried out in organic solvents or aqueous mixtures

Range of Enzyme TechnologyEnzyme Development• Enzyme screening kits

• Custom screening of enzymes

• Commercial enzymes

Enzyme Production• Large scale production of enzymes

• Custom fermentation and fermentation development

Process Development• Large-scale production of chiral compounds, custom synthesis

and technology transfer

Enzyme Classes

Alcohol DehydrogenaseApplication: A broad range of carbonyl compounds (including

aldehydes, aliphatic, aromatic, cyclic ketones, diketones, ketoacetals and ketoesters) can be asymmetrically reduced to their correspond-ing chiral alcohols with high enantioselectivity using these enzymes.

Aldehyde ReductaseApplication: NAD(P) dependent dehydrogenation of primary

alcohols to the corresponding aldehydes and inverse reaction to give primary alcohols.

Esterases/Lipases Application: Enantioselective hydrolysis, synthesis and transesteri-

� cation of esters of primary, secondary and tertiary alcohols. Enanti-

oselective synthesis/hydrolysis of amides.

TransaminasesApplication: Asymmetric reductive amination via amino transfer

mechanism, for the synthesis of chiral amines.

Ene ReductaseApplication: Stereoselective reduction of alkenes.

Aldehyde DehydrogenenaseApplication: Aldehyde dehydrogenases catalyse the oxidation of

aldehydes to their corresponding carboxylic acides with NAD+NADP+ as cofactor.

Enzymatic system for Cofactor Recycling

Example Reactions

Asymmetric reduction of ethyl 3-ketobutyrate to ethyl (R)-3-hydroxybu-tyrate. (S)-speci� c ADH for the reduction to the opposite enantiomer is also available.

Asymmetric reduction of 3,3,4,4,4-penta� uorobutanone to (R)-penta� uo-robutan-2-ol. (S)-speci� c ADH for the reduction to the opposite enantio-mer is also available.

Asymmetric reduction of 2-acetylpyridine to (R)-2-(1-hydroxyethyl)pyridine. (S)-speci� c ADH for the reduction to the opposite enantiomer is also available.

ADH

NAD(P)+

O

OO

BrO

OOH

Br

NAD(P)H

ADH

NAD(P)+

O

F

F

F

FF

OH

F

F

F

FF

NAD(P)H

ADH

NAD(P)+

N

OH

N

O

NAD(P)H

Alcohol Dehydrogenases (ADH)For Biocatalytic Ketone Reduction

Application: Stereoselective reduction of ketones to produce enantio-merically-pure alcohols

• Broad range of ketones reduce with high stereo-selectivity

• Both R and S alcohols can be produced

• Yields often near 100% of theoretical

• Mild conditions; few, if any, side product

Examples of structurally diverse ketones:

Products include:

• Tens of di� erent commercially available ketoreductases

• Enzymes sold in convenient screening set for rapid

identi� cation of the best biocatalyst for a desired reduction.

• All enzymes available on commercial scale

JOHNSON MATTHEY CATALYSIS AND CHIRAL TECHNOLOGIES is pleased to o� er a continually expanding, novel family of

biocatalysts which enhances the chiral capabilities of our chemo-catalyst technology o� ering. This combined portfolio of catalytic

technology allows us to design the most e� ective synthetic route for our clients.

You now have one reliable resource for your chemo- and biocatalysis needs.

O

2-heptanone Ethyl 4,4,4-trifl oro-3-ketobutyrate

Ethyl 3-keto-butanoate 3,3,4,4,4-pentafl uorobutanone

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