John Paquet III BME 181 S01 04 March 2013. Deteriorates memory, cognition, and behavioral abilities...
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Transcript of John Paquet III BME 181 S01 04 March 2013. Deteriorates memory, cognition, and behavioral abilities...
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John Paquet IIIBME 181 S0104 March 2013
![Page 2: John Paquet III BME 181 S01 04 March 2013. Deteriorates memory, cognition, and behavioral abilities Progressively worsens with age Memory loss,](https://reader035.fdocuments.in/reader035/viewer/2022070412/5697bf811a28abf838c8580b/html5/thumbnails/2.jpg)
Deteriorates memory, cognition, and behavioral abilities
Progressively worsens with age
Memory loss, difficulty sleeping, uncontrollable behavior, confusion
Cannot be cured, prevented, or slowed
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Affects 5.4 million people in US 6th leading cause of death in US 3rd costliest disease in US for healthcare costs
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Fornix◦Memory
Frontal lobe◦Behavior and cognition
Junctions of cognition, behavior, and memory pathways◦ To reduce impact of plaques
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Few tests thus far, but promising results Find certain letters/shapes among many on paper◦With pacemaker off, found a couple◦After period of constant stimulation, found 30
Pilot trial of 6 patients in Canada◦After year of continuous stimulation:
improved memory Significantly more brain activity
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Normal risks of brain surgery
Complications if parts break or move around
Dizziness, speech or vision issues, others◦ Potentially reversible
Treatment of AD with DBS may cost $50-100k for insurance◦May come down by time treatment is available
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Current drugs have been ineffective
DBS could help people with early-stage or mild AD◦Much of connectivity remains
Potential for reviving circuitry in the brain provides hope amidst the Alzheimer’s epidemic
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Alzheimer's Association. 2012 Alzheimer's disease facts and figures. Alzheimer's and Dementia: The Journal of the Alzheimer's Association. March 2012; 8:131–168.
“Alzheimer’s disease.” A.D.A.M. Medical Encyclopedia. U.S. National Library of Medicine, 26 Sept. 2011 <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001767/>
“Deep Brain Stimulation.” CNS Diseases. 2013 <http://cnsdiseases.com/deep-brain-stimulation> “Deep brain stimulation.” MedlinePlus Medical Encyclopedia. U.S National Library of Medicine. U.S.
National Library of Medicine, 27 Feb. 2013 <http://www.nlm.nih. gov/medlineplus/ency/article/007453.htm>
“Deep brain stimulation.” Wikipedia. Wikimedia Foundation, 03 Jan. 2013 http://en.wikipedia. org/wiki/Deep_brain_stimulation>
“Electric brain stimulation may treat Alzheimer's.” CBSNews. CBS Interactive, 21 Jan. 2013 <http://www.cbsnews.com/ 8301-204_162-57564987/electric-brain-stimulation-may-treat-alzheimers/>
“Ohio State Implants First Brain Pacemaker To Treat Alzheimer's.” The Ohio State University Wexner Medical Center, 22 Jan. 2013 <http://medicalcenter.osu.edu/mediaroom/releases/Pages/Ohio-State-Implants-First-Brain-Pacemaker-To-Treat-Alzheimer's.aspx>
“Pacemaker-like device studied in Alzheimer's treatment.” CBSNews. CBS Interactive, 6 Dec. 2012 <http://www.cbsnews.com/ video/watch/?id=50136498n>