John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau...
-
Upload
jayson-skinner -
Category
Documents
-
view
214 -
download
0
Transcript of John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau...
![Page 1: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/1.jpg)
John Marks MDChief: Section of Colorectal Surgery Main Line Health System
Professor: Lankenau Institute of Medical Research
Director: Fellowship in Minimally Invasive Colorectal Surgery and Rectal Cancer Management
When to operate for diverticulitis: Acute vs Chronic
![Page 2: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/2.jpg)
• 50% > 60 years• 80% > 80 years• 10% of those with diverticulosis may go on to develop
diverticulitis– 75% of cases are simple– Very small subset require surgery
Incidence of Diverticulosis
![Page 3: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/3.jpg)
• Simple
• Complicated– Abscess– Fistula– Stenosis
• Perforation
Diverticulitis: A Spectrum
![Page 4: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/4.jpg)
• Study selection bias• Few prospective randomized trials
– Patrick Ambrosetti MD
• Overall Studies are of poor quality overall
Studying Diverticulitis
![Page 5: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/5.jpg)
• Acute– Free perforation– Peritonitis– Acute abdomen
When to Operate
![Page 6: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/6.jpg)
• Chronic– Complicated diverticulitis
• Abscess• Fistula• Stenosis
– Medically refractory– 2 or more hospitalizations– 1 hospitalization < 50 yrs– Immunocompromised
When to Operate: Standard Teaching
![Page 7: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/7.jpg)
Hinchey Classification
• Stage I: Pericolic abscess or phlegmon
• Stage II: Pelvic, intra-abdominal or retroperitoneal abscess
• Stage III: Generalized purulent peritonitis
• Stage IV: Generalized fecal peritonitis
![Page 8: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/8.jpg)
• Classic indications called into question• Minority of patients develop subsequent attacks• Are we justified in telling people that they will
avoid life threatening situations with elective resection?
• What is the effect on QOL?
Simple Diverticulitis
![Page 9: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/9.jpg)
• Percutaneous drainage of abscess• Hartmann’s
– Laparoscopic vs. Open• Resection with primary anastomosis
– proximal diverting stoma– on table lavage
• Laparoscopic lavage
Complicated Diverticulitis Options
![Page 10: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/10.jpg)
Overall Diverticulitis RecurrencesN = 502
Timing of first recurrent attack of acute diverticulitis for all patients.
Eglinton et al. Br J Surg 2010
![Page 11: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/11.jpg)
Simple DiverticulitisN = 320/502
Timing of first recurrent attack of acute diverticulitis for patients with an uncomplicated first attack.
Eglinton et al. Br J Surg 2010
![Page 12: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/12.jpg)
Complicated DiverticulitisN = 165
Timing of first recurrent attack of acute diverticulitis for patients with a complicated first attack.
Eglinton et al. Br J Surg 2010
![Page 13: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/13.jpg)
• “The timing of elective colectomy in diverticulitis: A decision analysis.” Salem et al. J Amer Coll Surg 2004– Markov model of clinical pathways– Simulation based on statewide hospital discharge
database– Colectomy after 4th episode
• lower mortality• Fewer colostomy • Decreased cost
Timing of Elective Colectomy in Diverticulitis
![Page 14: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/14.jpg)
Management Strategies
Salem et al. J Amer Coll Surg 2004
![Page 15: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/15.jpg)
• “Timing of prophylactic surgery in prevention of diverticulitis recurrence: A cost-effectiveness analysis.” Richards et al. Dig Dis Sci 2002.– Markov model as well– Probabilities based on published data– Compared surgery after 1, 2 and 3 episodes– Surgery after 3rd attack = decreased cost
Timing of Elective Colectomy in Diverticulitis
![Page 16: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/16.jpg)
Timing of Elective Colectomy in Diverticulitis
Richards et al. Dig Dis Sci 2002.
![Page 17: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/17.jpg)
• Urgent admissions: big increase• Urgent surgery: very small increase
– Improvement in antibiotics– Interventional procedures
• Elective surgery: increasing– Laparoscopy
Trends in Management2002 – 2007
![Page 18: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/18.jpg)
Masoomi et al. Arch Surg 2010
Diverticulitis Admissions
(2002) 179k 210k (2007)
Nationwide Inpatient Sample (NIS) database
![Page 19: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/19.jpg)
Masoomi et al. Arch Surg 2010
Elective & Urgent Surgeries
![Page 20: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/20.jpg)
Masoomi et al. Arch Surg 2010
Role of Laparoscopic Resection
![Page 21: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/21.jpg)
• Percutaneous drainage of abscess• Hartmann’s
– Laparoscopic vs. Open• Resection with primary anastomosis
– proximal diverting ileostomy– on table lavage
• Laparoscopic lavage
Complicated Diverticulitis Options
![Page 22: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/22.jpg)
• Gold standard for Hinchey III & IV• Significant complications
– Wound infection 30%– Stoma complications 10%– Leak rate 30% with reversal– Overall mortality 15-30%
• Primary resection & anastomosis for Hinchey I & II• Resection & anastomosis w/ protective stoma for
Hinchey III
Hartmann’s Procedure
![Page 23: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/23.jpg)
• Alternative for Hinchey I and II– Diverting proximal stoma for Hinchey III
• Reduced post-operative mortality• Avoidance of stoma• Lower SSI• Studies flawed with selection bias• No large randomized trials
Hartmann’s vs. Primary Anastomosis
![Page 24: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/24.jpg)
Bauer VP, Clinics in Colorectal Surgery 2009
Hartmann’s vs. Primary Anastomosis
N = no. of patients
MortalityStoma
ComplicationAbdominal
AbscessAnastomotic
LeakWound
Infection
Abbas et al, 2007
18 studies
HP 526 19% 7-12% 8% 22.6%
HP reversal 8%PRA 358 9% 4% 5.5% 14%
Salem et al, 2004
54 studies
HP 1051 18% 10.3% 24.2%
HP reversal 787 0.8% 4.3% 4.9%PRA 569 9.9% 9.6%
Constantinides et al, 2006
15 studies
HP 416 15.1% 8.7% 22.3%
HP reversal 3.9%PRA 547 4.9% 3.9% 9.6%PRA & stoma 8.3%
![Page 25: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/25.jpg)
• Franklin et al. World J Surg, 2008• N = 40• All pts with peritonitis • 33% with free air on CXR• Hinchey 2b, 3 and 4 (intraop finding)• No readmissions for complicated disease
– Average f/u 96 months (range 1 – 120 months)
• 24 patients underwent subsequent elective surgery
Laparoscopic Lavage Methods
![Page 26: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/26.jpg)
• Described for Hinchey class II, III, & IV• Culture of purulent material• 4 – 12 L of warm saline reported• Drain placement near colonic lesion• Adhesions to the colon left untouched• Visible perforations closed w/ suture, omental patch,
fibrin glue• IV antibiotics x 7 days minimum
Laparoscopic Lavage Methods
![Page 27: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/27.jpg)
• Karoui et al. Dis Colon & Rectum 2009• N = 59
– 35 lavage– 24 resection with anastomosis and diverting ostomy
• Case matched study• Hinchey 3
Laparoscopic Lavage Methods
![Page 28: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/28.jpg)
Laparoscopic Lavage
Karoui et al. Dis Colon & Rectum 2009
N = 59
![Page 29: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/29.jpg)
Lavage vs. Resection w/ IleostomyLaparoscopic Group Open Group P
Stage I N = 35 N = 24 Mortality 0 0 Morbidity 10 (28%) 10 (42%) NS Abdominal 4 (11%) 7 (29%) NS Extra-abdominal 6 (17%) 3 (12.5%) NSLOS (days, median, ranges) 8 (5-18) 17 (11-52) <0.0001Stage 2 N = 25 N = 24 Mortality 0 0 NS Morbditiy 3 (12%) 3 (12.5%) NS Abdominal 2 (8%) 2 (8%) NS Extra-abdominal 1 (4%) 1 (4%) NSLOS (days, median, ranges) 7 (5-11) 6 (4-10) NSStage 1 + Stage 2 N = 25 N = 24 Mortality 0 0 Morbidity 6 (24%) 12 (50%) NS Abdominal 4 (16%) 9 (37.5%) 0.0507 Extra-abdominal 3 (12%) 4 (17%) NSLOS (days, median, ranges) 14 (11-24) 23.5 (16-52) < 0.0001
Karoui et al. Dis Colon & Rectum 2009
N = 59
![Page 30: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/30.jpg)
Accuracy of CT Hinchey Class
![Page 31: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/31.jpg)
Alamili et al. Dis Colon & Rectum 2009
Laparoscopic Lavage
![Page 32: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/32.jpg)
• Diverticulitis vs IBS• Evidence of diverticula only on CT• No fever or leukocytosis• 88% pain-free at 12 months• Histologic evidence of inflammation in 76%
Smoldering DiverticulitisN = 47
Horgan et al. Dis Colon & Rectum 2001
![Page 33: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/33.jpg)
• N = 46• Patients evaluated had CT documented attack of diverticulitis• Multiple validated questionnaires used preop, 3, 6 and 12 months
post-op• Evaluation of GI, urologic and sexual function
– GIQLI – IPSS (international prostate symptom score) - men– EIIF-5 (international index of erectile function)– UDI (urinary distress inventory) - women
Quality of Life after Lap Colectomy
Forgione et al. Annals of Surgery, 2009
![Page 34: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/34.jpg)
Quality of LifeN = 46
*denotes significant difference (P < 0.05).
Forgione et al. Annals of Surgery, 2009
![Page 35: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/35.jpg)
• Functional results following elective laparoscopic sigmoidectomy
after CT-proven diverticulitis. – Ambrosetti et al, J Gastrointest Surg 2007
• N = 43• Mean follow up 40 months (3-76)• Post operative questionnaire
– Recurrent disease– Bowel function– New abdominal pain– Overall satisfaction
• Overall satisfaction rate 95%
Functional Results
![Page 36: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/36.jpg)
Postoperative Results
Results Number of Patients(N)
Percentage(%)
Bowel function Better 24 56 Unchanged 16 37 Worse 3 7New abdominal pain 4 9.3Degree of satisfaction Excellent 20 47 Good 17 40 Mediocre 6 13Would you go back to surgery 41 95
Recurrence 0
N = 43
Ambrosetti et al, J Gastrointest Surg 2007
![Page 37: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/37.jpg)
Why the CT appreciation of severity?
A. To guide the therapeutic strategies:1. Mild diverticulitis: conservative ambulatory care
(antibiotics?)2. Stage Ia: conservative care with oral antibiotics3. Stage Ib and II: hospitalization, iv antibiotics, eventual CT
drainage, possible surgery4. Stage III and IV: surgery
B. To evaluate the chances of secondary bad outcome after a first episode of acute diverticulitis susccessfully treated conservatively
![Page 38: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/38.jpg)
So, where is the challenge ?
The existence of an associated abscess
![Page 39: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/39.jpg)
Why ?
1. Frequent (between 15 to 20%)
rao et al. am j radiol 1998ambrosetti et al. eur radiol 2002werner et al. eur radiol 2003
2. Difficult to diagnose bioclinically 3. Therapeutically challenging
![Page 40: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/40.jpg)
Types of acute treatment
Should we drain ?« …small pericolic abscess may resolve with antibiotic therapy and bowel rest… »« …today the decision to drain remains to be individualized 1 »
1. The Standard Task Force and the American Society of Colon and Rectum Surgeons, Dis Colon Rectum 2000; 43: 289-97
![Page 41: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/41.jpg)
Secondary treatment
1. « Recently, some surgeons have suggested that surgical resection may not be mandatory in every case after successful percutaneous drainage: however, at present there are insufficient data to support universal endorsement of this concept »
The Standard Task Force and the American Society of Colon and Rectum Surgeons, Dis Colon Rectum 2000; 43: 289-97
2. « …do a percutaneous drainage where possible, followed later by sigmoid resection in most cases… »
European Association of Endoscopic Surgery, Surg Endosc 1999; 13: 430-6
![Page 42: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/42.jpg)
Abscess associated to diverticulitis
• Between october 1986 to october 1997:– 465 patients had a CT evaluation– 76 (16.3%) had an associated mesocolic or
pelvic abscess– 73 patients could be followed-up– Median follow-up: 43 months (2 – 180)
– 26 women and 47 men with a mean age of 68 (30 – 94)
Ambrosetti et al. Dis colon rectum, march 2005
![Page 43: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/43.jpg)
Abscess associated to diverticulitis
• Therapeutic principles:– Percutaneous CT drainage of abscess were done
only if no bioclinical improvement were noted after 48 hours of parenteral antibiotics
– Elective colectomy after successful conservative management of the abscess was not an absolute indication and was adapted for each patient
![Page 44: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/44.jpg)
Associated abscess
Location and CT percutaneous drainage
n drained not drained (%) (%)
Mesocolic 45 11 (24) 34 (76)Pelvic 28 8 (29) 20 (71)
![Page 45: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/45.jpg)
Surgical vs conservative treatment:no op.: conservative treatment
op. 1: surgery during 1st hospitalisationop. 2: surgery later on
N No op. (%)
Op. 1 (%)
Op. 2 (%)
mesocolic 45 22 (49) 7 (15) 16 (36)
Pelvic 28 8 (29) 11 (39) 9 (32)
![Page 46: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/46.jpg)
Long-term evolution
1. No patient needed an emergency surgical treatment
2. 15 patients (21%) died during the course of the follow-up. No one died from complications related to the diverticular disease
![Page 47: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/47.jpg)
Essential findings
1. Initial CT is indispensable to confirm the diagnosis and precise the severity of the diverticulitis
2. Patients with a pelvic abscess should be immediately drained
3. Mesocolic abscess ≥ 5 cm should probably be drained immediately
4. Secondary colectomy after pelvic abscess seems highly reasonnable
5. Secondary colectomy after successful conservative treatment of mesocolic abscess is probably not mandatory for all patients
![Page 48: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/48.jpg)
Acute left colonic diverticulitis
Prospective study October 1986 – October 1997 University Hospital Geneva
![Page 49: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/49.jpg)
Acute diverticulitis: prospective study
542 patients290 women and 252 men
Mean age: 64 (23-97)
![Page 50: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/50.jpg)
Acute diverticulitis: profile of the study
Patients included:1. Clinical and history compatibility2. Radiological confirmation (CT and water-soluble contrast enema=GE)3. Histological diagnosis4. 1st hospital admission
Patients excluded:No radiological or histological confirmation
![Page 51: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/51.jpg)
Acute diverticulitis: radiological criteria (CT and GE)
Moderate diverticulitis Severe diverticulitis
CT: localized wall thickening (>=5mm)
Inflammation of pericolic fat
The same + at least one of the following:Abscess
Extraluminal air/ contrast
GE: segmental lumen narrowing
Tethered mucosa+/- mass effect
The same + at least one of the following:
Extraluminal air/ contrast
![Page 52: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/52.jpg)
Acute diverticulitisLong-term follow-up after a 1st acute episode
of left colonic diverticulitis:is surgery mandatory ?
R. Chautems, P. Ambrosetti, C. SoraviaAmerican Society of Colorectal Surgeons
San Diego, June 2001
Dis Colon Rectum 2002; 45: 962-966
![Page 53: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/53.jpg)
Acute diverticulitis: aims of the study
• To evaluate on a long term (9.5 years) the outcome of 118 patients treated medically with success for a 1st episode of diverticulitis
• To determine risk factors of poor evolution• To assess the place of surgery• To propose a timing for surgery
![Page 54: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/54.jpg)
Acute diverticulitis:Post hospitalisation evolution
No complications: 80 patients (68%)
Evolutive complications: 38 patients (32%)
24 deaths (20%)
21 not related to diverticular diseaseNo emergency operation
![Page 55: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/55.jpg)
Identification of initial parameters predictive of evolutive complications
Age
Severity of the inflammation on CT
![Page 56: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/56.jpg)
• Diverticulitis is common• Most patients w/ initial episodes of disease will not
recur• Most patients who undergo surgery in elective
circumstances are very satisfied w/ their outcomes• Laparoscopic resection for diverticulitis is safe and
effective
Conclusion
![Page 57: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/57.jpg)
• 284 patients with diverticulitis treated laparoscopically• 143 had previous abdominal surgery• Procedures
– 256 L colectomy– 1 AR Rectopexy– 3 Hartmann’s Procedures– 12 Hartmann’s Reversal– 12 Other
Our Laparoscopic Experience
![Page 58: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/58.jpg)
• ASA Class– 11 patients ASA Class I– 143 patients ASA Class II– 121 patients ASA Class III– 4 patients ASA Class IV– 5 patients ASA Class N/A
• Average OR Time 271 minutes (112 – 894 minutes)• Avg EBL 189 cc (10 – 1200cc)• Avg largest incision 5.3 cm (1.5 – 15.0 cm)• Avg Discharge POD 5.2 days (2 – 43 days)
Our Laparoscopic Experience
![Page 59: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/59.jpg)
• Morbidity 10.6%– 2 atrial fibrillation– 2 anastomotic leak– 1 anastomotic stenosis– 5 arrhythmia– 2 bowel perforation– 1 DVT– 3 GI bleed– 1 internal hernia– 3 intraabdominal abscess– 2 UTI– 4 wound infection
– 2 prolonged ileus– 1 aspiration pneumonia– 1 anemia– 1 sepsis– 1 drug rash– 1 intraabdominal hematoma
• 1 Mortality 0.3%
Our Laparoscopic Experience
![Page 60: John Marks MD Chief: Section of Colorectal Surgery Main Line Health System Professor: Lankenau Institute of Medical Research Director: Fellowship in Minimally.](https://reader035.fdocuments.in/reader035/viewer/2022062517/56649eba5503460f94bc24d5/html5/thumbnails/60.jpg)
• Conversion Rate 1.4%– All converted to laparoscopic assisted lower
midline incision– Dense adhesive disease
Our Laparoscopic Experience