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  • Journal of Ayurveda Official publication of National Institute of Ayurveda, Jaipur, Rajasthan 95

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    ORIGINAL REASEARCH ARTICLE - PHARMACEUTICAL STUDY

    Pharmaceutical and Analytical Exploration Of Sanjivani Vati - An Ayurvedic Formulation

    *Dr. Vimal Tewari, **Dr. Deepika Tewari, ***Dr. Amit Kumar Dixit

    *R.O.(Ayu.), **R.O.(Ayu.), RARIID, Patna, CCRAS, Ministry of AYUSH, Government of India, Patna, ***R.O.(Ayu.), RARIMD, CCRAS, Ministry of AYUSH, Government of India, Bengaluru.

    ABSTRACT

    Sanjivani vati is a common Ayurvedic polyherbal formulation described in Ayurvedic formulary of India and widely used for various communicable diseases and other ailments i.e. fever especially infectious (Visham jwara), cold, cough, urinary tract infections, indigestion (Ajirna), and helps to strengthen the immune system and hence re- juvenate the body. Sanjivani vati comprise equal parts of Vidanga, Sunthi, Pippali, Haritaki, Amalaki, Vibhitaki, Vaca, Guduchi, Bhallataka and Vatsanabha. Gomutra (Cow urine) a very essential component is used to levigate the ingredients which helps to bind the pills. It has tremendous effects on fever, indigestion (Ajirna) and upper respiratory tract infection. Vatsnabha and Bhallataka are the two poisonous drugs among the components that increase its quality tremendously. In the present study, an attempt has been made to congregate the various reference of Sanjivani vati to show diversity in formulary and therapeutic indications. Sanjivani vati has been prepared in the pharmacy by follow- ing the standard operative procedures and Qualitative and Quantitative characterization of the drug was evaluated by using standard guidelines. The data generated in the present study may serve as a beneficial tool to maintain the quality aspects of Sanjivani vati.

    Keywords : Sanjivani vati; Physicochemical; Polyherbal; Gomutra; Ayurveda

    Address of Correspondence: Dr. Vimal Tewari R.O. (Ayu.), CCRAS, Ministry of AYUSH, GoI, Patna

    Email ID : vimalayuccras@gmail.com

    Contact No : 8840816388

    Introduction:

    Ayurvedic system of medicine is one of the most ancient sciences that have holistic approach towards patients. It is full of fundamental principles for better health and longevity of life. Its empirical guidelines help in maintaining a balance in the body, mind and consciousness through disciplined lifestyle and in

    How to Site the Article : Tewari V, Tewari D, Dixit AM, Pharmaceutical and Analytical Exploration Of Sanjivani Vati - An Ayurvedic Formulation, JOA XIII-3, 2019; 95 - 101

    JOA journalofayurveda.in ISSN No:2321-0435

  • Journal of Ayurveda Official publication of National Institute of Ayurveda, Jaipur, Rajasthan 96

    Tewari V, Tewari D, Dixit AM, Pharmaceutical and Analytical Exploration Of Sanjivani Vati - An Ayurvedic Formulation, JOA XIII-3, 2019; 95 - 101

    treating ailments as well. Ayurvedic medicines help the body by its two principle i.e. enhancing body’s inbuilt ability of fighting and treat the illness itself. Sanjivani vati have unique combination of various herbal drugs and Cow urine helps to rejuvenate and strengthen the body so increases immune power to counteract the adverse conditions and treat the ailment also. Since many decades Sanjivani vati have been recommended in the treatment of diseases of diverse origin as it has very balanced and appropriate combination of those herbal drugs that affect almost all body tissues and make them strong to endure adverse condition.

    First time Saragdhar wrote this formulation in his book under vati kalpana. In this formulation, the powder of Vidang (Embelia ribes), Nagara (Zingiber officinale), Pippali (Piper longum), Haritaki (Terminalia chebula.), Amalaki (Phyllanthus emblica), Vibhitaka (Terminalia bellirica), Vaca (Acorus calamus), Gudduci (Tinospora cordifolia), Bhallataka (Semecarpus anacardium), and Vatsanabha (Aconitum ferox) in equal amount have been taken & levigate them with Cow urine (Gomutra). After levigation pills of the weight of ‘Gunja’ is made. It has been indicated in Ajirna, Gulma, Visuchika, Sarpadansta and Sannipata. Sarangdhar mentioned ‘Adraka swarasa’ as anupana in all aforesaid disorders[1].

    In routine practice it is used in high grade fever like typhoid, malaria and other of unknown origin. It is helpful in allergic rhinitis and arrests loose motions in intestinal infections & worm infestation. In general way it is always used to alleviate the symptoms found in gastro intestinal disturbances. It corrects the Vata, Kapha and Vata-Kapha dominant conditions. It is stated that the recommendation of Sanjivani vati in Pitta predominant

    Prakruti and Pitta predominant diseases should be in strict surveillance. The reference of Sarandhar samhita has been quoted by Ayurvedic formulary of India (AFI) also and is supposed to be used by either manufacturer[2]. Proper validation and standardization of herbal preparations is utmost important in developing era. This is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or a quality assurance for production and manufacturing of drugs. Therefore, the present was undertaken to set some important parameters for the standardization of widely used Ayurvedic herbal formulation Sanjivani vati.

    Material & Methods

    Literature review

    A comprehensive review has been made to compile the various reference of Sanjivani vati to show diversity in formulary and therapeutic indications. The data available is presented in a systematic manner with reference to their ingredients, therapeutic uses, dose, dosage form and anupana.

    Procurement of ingredients

    For a standard finished product, the raw materials of acceptable variety & standards have been obtained from N.I.A. Pharmacy where certification of identity & purity is done by well-established standardization shell. Fresh cow urine was collected from nearby cowshed. Among the ingredients Bhallataka and Vatsanabha are two poisonous herbal drugs used, so purification of its part is necessary before using in preparation of Sanjivani vati. The table 1 exhibits the desirable part of the plant and its weight that have been used in the preparation of Sanjivani vati.

    Table I. Contents, part used and their quantity used in the preparation of Sanjivani vati.

    S. No. Name of Drug Part used Form of

    Part used Weight

    (Powder) Vidanga Fruit Powder 15gm Sunthi Rhizome Powder 15gm Pippali Fruit Powder 15gm

    Haritaki Fruit rind Powder 15gm

  • Journal of Ayurveda Official publication of National Institute of Ayurveda, Jaipur, Rajasthan 97

    Tewari V, Tewari D, Dixit AM, Pharmaceutical and Analytical Exploration Of Sanjivani Vati - An Ayurvedic Formulation, JOA XIII-3, 2019; 95 - 101

    Amalaki Fruit rind Powder 15gm Vibhitaki Fruit rind Powder 15gm

    Vaca Root Powder 15gm Guduchi Stem Powder 15gm

    Bhallataka Fruit Powder 15gm Vatsanabha Root Powder 15gm Cow urine Urine Urine Quantity sufficient

    Purification of Bhallataka

    The fruit of Bhallataka has Tary oil in his pericarp that contains Anacardic acid which causes blisters when it comes in contact to the skin so it is utmost necessary to purify before use. Conventionally brick powder (Istika churna) is used to adsorb the oil from exposed fruit[3].

    A big bag containing brick powder (Istika churna) was made for the procedure. After removal of thalamus, the black and slightly hard top part of the fruits, the fruits were kept in deep of brick powder. Safety measures were followed to avoid any skin interaction. The whole arrangement was leaved for seven days. At the end of seventh day all fruits were rubbed rigorously in brick powder very safely. There after fruits were recollected and washed in water to remove adhered brick powder and dried in shade. The whole process has taken eight days to complete.

    Purification of Vatsanabha

    The process that is used for purification of Vatsanabha is called Swedana (Fomentation in sun). Vatsanabha is also a poisonous herbal drug. It is stated in the classic that it can be used orally after proper purification. Cow urine is stated for its purification[4].

    Fresh and dried roots of Vatsanabha were cut in small pieces and bundled in thin cloth. Knot was made very loose. Each bundle was kept in utensil full of cow urine. This whole arrangement was kept in sharp sun rays for three days and each day, cow urine was replaced totally. At the end of third day every bundle was taken out and all pieces of Vatsanabha were collected. There after roots were washed with fresh water. Further the whole pieces were kept in shade to dry completely. The whole process

    was taken four days to complete.

    Preparation of Sanjivani vati

    Sanjivani vati was prepared by following standard guidelines mentioned by Ayurvedic Formulary of India. (AFI-1, Section 12/35, P.No.154 (Sha. S. M. K. 7th Ch.18- 21). Fresh and dried part of every plant were powdered and sieved through 100 mesh sieve separately. Fine powder of all plants part of exact quantity 15 gm, were taken in a big steel utensil and mixed together properly. There after the whole mixture was kept in mortar. Fresh and measured quantity (500 ml) of cow urine, Bhavana Dravya, was taken and poured in mortar very gently. Sufficient quantity of cow urine is necessary whereby lump could not form during levigation. To blend the mixers uniformly an