James W. Tunnell - Department of Biomedical Engineering

1 of 21 Pages James W. Tunnell, Ph.D

James W. Tunnell Department of Biomedical Engineering

The University of Texas at Austin 1 University Station C0800

Austin, TX 78712-0238 512.232.2110

[email protected] http://www.bme.utexas.edu/research/tunnell/

EDUCATION AND TRAINING 2005 Postdoctoral Fellow, Massachusetts Institute of Technology, Cambridge, MA 2003 Ph.D. in Bioengineering, Rice University, Houston, TX 1998 B.S. in Electrical Engineering, University of Texas, Austin, TX PROFESSIONAL APPOINTMENTS 2011- Assoc. Professor, Biomedical Engineering, University of Texas at Austin, Austin, TX 2011- Undergraduate Faculty Advisor, Biomedical Engineering, University of Texas at Austin, Austin, TX 2005-2011 Asst. Professor, Biomedical Engineering, University of Texas at Austin, Austin, TX 2005-2006 Visiting Scientist, Spectroscopy Laboratory, MIT, Cambridge, MA 2005-2008 Faculty for NSF IGERT Program, University of Texas at Austin, Austin, TX 2002-2005 Postdoctoral Fellow, Spectroscopy Laboratory, MIT, Cambridge, MA 2001 Graduate Research Internship, R&D, Thermage Inc., Hayward, CA 1999 Visiting Research Assistant, Beckman Laser Institute, University of California, Irvine, CA 1995-1997 Cooperative Engineering Education Program, Motorola Inc., Boynton Beach, FL HIGHLIGHTED HONORS, AWARDS, PROFESSIONAL ACTIVITIES Chair, Engineering Conferences International, Advances in Optics for Biotechnology and Surgery, 2013 Outstanding Graduate Alumnus Award, Bioengineering, Rice University, 2010 ING Professor of Excellence, University of Texas, 2010 Coulter Fellow, Wallace H. Coulter Foundation, 2010 Program Chair, CLEO (Conf. on Lasers and Electro-Optics) - Applications Annual Meeting, 2011 Board of Associate Editors, Annals of Biomedical Engineering, 2010- Co-Chair, Technical Program – BMES (Biomedical Engineering Society) Annual Meeting 2010 Chair, Biological and Medical Applications Subcommittee – CLEO Annual Meeting, 2009 “20 Greatest Inventions of the Next Decade”, Business Week, 2009 Early Career Award (Phase II), Wallace H. Coulter Foundation, 2008 R01 Project Grant – National Institutes of Health/National Cancer Institute, 2008-2013 Ralph E. Powe Junior Faculty Enhancement Award, Oak Ridge Associated Universities, 2007 Early Career Award (Phase I), Wallace H. Coulter Foundation, 2006 National Research Service Award – National Institutes of Health/National Cancer Institute, 2004 Best Basic Science Paper (Student/Resident) – Am. Soc. for Laser Medicine and Surgery, 2000 Cox Fellowship, Rice University, 1998 Cooperative Engineering Education Program, University of Texas at Austin, 1998

HIGHLIGHTED RESEARCH ACTIVITIES Research Funding ($4.5M, 2005-2011): NIH, NSF, Coulter Foundation, Am Soc. Las. Surg. Peer reviewed journal articles/proceedings: 30/20 Patents and patent applications: 4 Professional memberships: Optical Society of America (OSA), The International Society for Optical Engineers

(SPIE), IEEE Engineering in Medicine and Biology (IEEE-EMBS), IEEE Photonics Society (IEEE-LEOS), Biomedical Engineering Society (BMES), Fellow-American Society for Laser Medicine and Surgery (ASLMS), American Society for Engineering Education (ASEE)


RESEARCH SUMMARY My current research program at the University of Texas at Austin focuses on two primary projects centered on the use of optical techniques for the diagnosis and treatment of cancer. Noninvasive diagnosis of skin cancer: A critical need exists for the noninvasive detection of skin cancer. The current standard-of-care in the identification of skin cancer is visual inspection followed by biopsy and histopathology of suspicious skin sites. Since a physician is required to perform this biopsy, there is often a delay in diagnosis, resulting in deeper, more aggressive tumors and increased mortality from malignant melanoma. Current estimates state that fifty biopsies are required to find a single melanoma skin cancer (MSC) and five biopsies are required to find a single nonmelanoma skin cancer (NMSC). Given the current incidence of MSC and NMSC in the US alone (60,000 and 1,200,000 per year, respectively), more than 8 million biopsies at a cost of about $2.8 billion are being performed each year on benign skin lesions. We are developing optical spectroscopy for the clinical, noninvasive diagnosis of skin cancer. We have developed a clinical spectrometer prototype (Rajaram Appl Opt 2010) and associated algorithms (Rajaram J Biomed Opt 2008, Rajaram Lasers Surg Med 2010) to perform a noninvasive spectral diagnosis, or a so called “optical biopsy”. We have recently conducted clinical pilot studies in collaboration with MD Anderson Cancer Center and the University of Texas Medical Branch. This device has been tested in over 100 patients, and our results demonstrate that the accuracy of this device is as good or better than the dermatologist’s clinical diagnosis, but without requiring a biopsy (Rajaram Lasers Surg Med 2010). This work has received over $1.3M from the Wallace H. Coulter Foundation (Phase I and II Early Career Awards), the National Institutes of Health, the Norman Hackerman Advanced Research Program, the American Society for Laser Surgery and Medicine, and DermDx Inc. The intellectual property generated from this work has been licensed to a startup company (DermDx Inc., Fresno, CA), and we are working collaboratively to conduct clinical trials and commercialize this technology. Combined imaging and treatment of solid tumors using nanovectors: Metal nanoparticles (NP) have gained interest as a novel platform for integrated cancer imaging and therapy due to their highly desirable spectral and molecular properties. Applications of NPs have recently been demonstrated for in vivo targeting and photothermal therapy of murine tumors. Much of the promise in this and related nanotechnologies rely not only on their therapeutic effect but also their diagnostic potential. However, there are currently limited techniques available for imaging these particles in vivo. We have developed three imaging strategies for metal nanoparticles for the combined imaging and treatment of solid tumors. First, we demonstrated for the first time that gold/silica nanoshells exhibit bright two-photon induced photoluminescence (TPIP) when excited using a NIR femtosecond laser. This finding enables their use as direct luminescence-based contrast agents for non-linear microscopy in bulk tissue (Park Opt Express 2008), and we have used this luminescence to characterize the NP’s targeting kinetics to solid tumors (Park Lasers Surg Med 2010). Second, we demonstrated that diffuse optical spectroscopy (DOS) can be used to measure NP concentrations within bulk tissue noninvasively (Zaman IEEE J Sel Top Quant Electr 2007). Finally, we have shown that NIR narrowband imaging (NBI) can be used as a noncontact intra-operative imaging technique to visualize wide-field distributions of NPs within tumors (Puvanakrishnan J Biomed Opt 2009). We are further developing this method to be used for margin demarcation during surgical excision of pancreatic tumors. These imaging technologies allow for both the study of the targeting kinetics of NP vectors as well as combined imaging and treatment strategies of cancer. Intellectual property for the DOS and NBI technologies have been licensed to private companies for further development and commercialization (Nanotox Inc. and Nanospectra Biosciences, respectively). These projects have received over $2.5M in funding from the National Institutes of Health, American Society for Laser Surgery and Medicine, and the Tate Foundation.


RESEARCH FUNDING Current and Completed

Role Co-PI Title Agency Tunnell Portion

Grant Total

Grant Period

Co-Principal Investigator Krishnan

Thermoradiotherapy - Development and Validation of a New Paradigm in Cancer Therapeutics.

Tate Foundation/

UT Seed Grant $14,375 $28,750 1/01/06 –

12/31/06

Principal Investigator Spectral Diagnosis of Early

Cutaneous Melanoma Coulter

Foundation $236,776 $236,776 8/01/06 – 07/31/08

Co-Principal Investigator Krishnan

In vivo quantitative tomographic imaging of EGFR-conjugated quantum dots.

Tate Foundation/

UT Seed Grant $10,000 $20,000 1/01/07 –

12/31/07

Principal Investigator In vivo tumor targeting using

metal nanoparticles

Oak Ridge Associated Universities

$5,000 $5,000 6/01/07 – 5/31/08

Principal Investigator

Metal nanoparticle mediated imaging, targeting, and treatment of cancer

NIH/NCI

R01 CA132032 $1,510,092 $1,510,092 5/05/08 –

2/27/13


Rajaram (student)

Effect of pigment packaging in diffuse reflectance measurements

American Society for

Laser Medicine and Surgery

$5,000 $5,000 7/01/08 – 6/30/09


Park (student)

Two photon imaging of tumors using nanoshells



$5,000 $5,000 7/01/08 – 6/30/09


Puvana-krishnan (student)

NIR narrowband imaging of gold/silica nanoshells in tumors



$5,000 $5,000 7/01/09 – 6/30/10


Multiphoton imaging and photothermal therapy of tumors using nanoshells



$130,944 $130,944 7/01/08 – 12/30/10

Principal Investigator Spectral Diagnosis of

Cutaneous Malignancy Coulter

Foundation $260,000 $260,000 8/01/08 – 01/31/11


Supplement: Metal nanoparticle mediated imaging, targeting, and treatment of cancer

NIH/NCI

R01 CA132032-02W1

$157,046 $157,046 9/01/09 – 2/27/12

Subcontract PI Goodrich

SBIR Phase I: Nanoparticle-based radio-imaging and ablation of lung cancer

NSF 0945088 $6,160 $149,296 1/1/10 – 10/31/10


Combined Raman, reflectance, and fluorescence spectroscopy for the detection of skin cancer.

DermDx Inc. $69,000 $69,000 5/1/10 – 10/31/10



Development of a hyper-spectral spectroscopic instrument for non-invasive diagnosis of cancer

NIH/NCRR

R21 RR026259 $554,400 $554,400 7/01/10 –

6/30/2013

Principal Investigator Noninvasive detection of skin

cancer

Texas Higher Education

Coordinating Board

$197,220 $197,220 7/01/10 – 8/31/12

Co-Principal Investigator

Krishnan/Schwartz

Integrated Imaging and Photothermal Ablation of Pancreatic Cancer Resection Margins

NIH/NCI

R21 CA133691 $110,000 $387,025 7/15/10 –

6/30/12

Co-Principal Investigator Schwartz

Narrowband Imaging of Breast Cancer Margins Using Nanoparticles to Guide Surgical Resection

NIH/NCI

SBIR Topic 286 $59,918 $200,000 9/24/10 –

5/31/10


Shared instrumentation grant: Multiphoton microscope for biomedical engineering applications

NIH/NCRR

S10 RR027950 $600,000 $600,000 4/1/11 –

3/31/12

Totals $3,935,931 $4,520,549

Pending

Role Co-PI Title Agency Tunnell Portion

Grant Total

Grant Period

Co-Principal Investigator

Naga-varapu

Multi modal (DDx) device for diagnosis of skin cancer

NIH/NCI

1R43RR030758$236,000 $706,706 9/01/11 –

8/31/13


Noninvasive Skin Cancer Diagnosis Using Multi-modal Spectroscopy

NIH/NIBIB

1R01EB014948 $2,438,774 $2,438,774 4/01/12 –

3/31/17


Noninvasive Skin Cancer Diagnosis Using Multi-modal Spectroscopy

CPRIT $1,400,000 $1,400,000 12/01/11 –11/30/14


REFEREED PUBLICATIONS

In Preparation

Nichols B, Rajaram N, Tunnell JW. Performance of a look-up table based approach for measuring tissue optical properties with diffuse optical spectroscopy. Biomed Opt Express (in prep), 2011

Puvanakrishnan P, Park J, Bish S, Tunnell JW. Fractional dosing of metal nanoparticles to solid tumors enhances uptake. ACS Nano, 2011

Puvanakrishnan P, Tunnell JW. System for real-time narrowband imaging of plasmonic nanoparticles in tissue. Appl Opt, 2011

Lim L, Nichols B, Rajaram N, Migden M, Reichenberg J, Tunnell JW. Noninvasive diagnosis of melanoma using muilti-modal spectroscopy. Science Translational Medicine (in prep.), 2011

In Review

Izquierdo-Roman A, Vogt WC, Robertson JL, Lim L, Nichols B, Tunnell JW, Rylander CG. Effects of localized compression on diffuse reflectance spectra of ex vivo porcine skin. Lasers Surg Med (in review) 2011

Vogt WC, Izquierdo-Román A, Nichols B, Lim L, Tunnell JW, Rylander CG. Effects of Mechanical Indentation on Diffuse Reflectance Spectra, Light Transmission, and Optical Properties in Ex Vivo Porcine Skin. Lasers in Surgery and Medicine (in review) 2011

Puvanakrishnan P, Tunnell JW. Narrow band imaging of squamous cell carcinoma tumors using topically delivered anti-EGFR conjugated gold nanorods. Lasers Surg Med, (in review) 2011

Pattani V, Tunnell JW. Thermal efficiency of nanorods and nanoshells for heating biological tissues. Lasers Surg. Med. (in review), 2011

Published/In press

1. Bish S, Rajaram N, Nichols B, Tunnell JW. A noncontact probe for diffuse optical spectroscopy of tissue. J Biomed Opt (in press), 2011

2. Zaman R, Oliver J, Welch AJ, Tunnell JW, Zhang XJ, Rylander HG, Micro-patterned Drug Delivery Device for Light-Activated Drug Release. Lasers Surg Med (in press) 2011

3. Hessel CM, Pattani V, Rasch M, Panthani M, Koo B, Tunnell JW, Korgel BA, Copper Selenide Nanocrystals for Photothermal Therapy Nano Letters 11(6):2560-2566, 2011

4. Barman I, Dingari NC, Rajaram N, Tunnell JW, Dasari RR, Feld MS. Rapid and accurate determination of tissue optical properties using least-squares support vector machines. Biomedical Optics Express 2(3): 592–599, 2011 [PMCID: PMC3047364]

5. Zaman RT, Rylander HG, Rajaram N, Wang T, Asokan N, Tunnell JW, Welch AJ. Changes in morphology and optical properties of sclera and choroidal layers due to hyperosmotic agent. J Biomed Opt 16(7), 077008, 2011

6. Lim L, Rajaram N, Nichols B, Tunnell JW. The effect of probe pressure on combined diffuse reflectance and laser induced fluorescence spectroscopy of in human skin. J Biomed Opt 16, 011012, 2011

7. Zaman RT, Rajaram N, Walsh A, Oliver J, Rylander HG, Tunnell JW, Welch AJ, Mahadevan-Jansen A. Variation of Fluorescence in Tissue with Temperature. Lasers Surg Med 43(1):36-42, 2011

8. Rajaram N, Reichenberg JS, Migden M, Nguyen T, Tunnell JW. Pilot clinical study for quantitative spectral diagnosis of non-melanoma skin cancer. Lasers Surg Med 42:716-727, 2010

9. Wang Y, Bish S, Tunnell JW, Zhang XJ. MEMS Scanner enabled real-time Depth sensitive Hyperspectral Imaging of Biological Tissue. Opt Express 18(23):24101–24108, 2010 (also appeared in Virtual Journal of Biomedical Optics 6(1), 2010)

10. Hessel CM, Rasch M, Hueso JL, Goodfellow B, Akhavan VA, Puvanakrishnan P, Tunnell JW, and Korgel BA. Alkyl Passivation and Amphiphilic Polymer Coating of Silicon Nanocrystals for Medical Diagnostic Imaging. Small 6(18):2026-2034, 2010


11. Park J, Estrada A, Schwartz JA, Diagaradjane P, Krishnan S, Dunn AK, Tunnell JW. Intra-organ biodistribution of gold nanoparticles using intrinsic two photon induced photoluminescence. Lasers Surg. Med. 42(7):630-639, 2010 (cover feature)

12. Yan C, Pattani V, Tunnell JW, Ren P. Temperature-induced unfolding of epidermal growth factor (EGF): insight from molecular dynamics simulation. Journal of Molecular Graphics and Modeling 29:2-12, 2010

13. Rajaram N, Gopal A, Zhang X, Tunnell JW. Experimental validation of the effects of microvasculature pigment packaging on in vivo diffuse reflectance spectroscopy. Lasers Surg. Med. 42:680–688, 2010

14. Erickson T, Mazur A, Cuccia D, Durkin A, Tunnell JW. A Lookup-Table Method for Imaging Optical Properties with Structured Illumination Beyond the Diffusion Theory Regime. J Biomed Opt 15(3):036013, 2010

15. Rajaram N, Aramil T, Lee K, Reichenberg JS, Nguyen TH, Tunnell JW. Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy. Appl Opt 49(2):142-152, 2010 (also appeared in Virtual Journal of Biomedical Optics, 5(3), 2010)

16. Puvanakrishnan P, Park J, Diagaradjane P, Schwartz JA, Coleman C, Gill-Sharp KL, Sang KL, Payne JD, Krishnan S, Tunnell JW. Near infrared narrowband imaging of gold/silica nanoshells in tumors. J Biomed Opt 14(2):024044, 2009

17. Lau C, Scepanovic O, Mirkovic J, McGee S, Yu CC, Fulgham S, Wallace M, Tunnell JW, Bechtel K, Feld MS. Re-evaluation of model-based light scattering spectroscopy for tissue spectroscopy. J Biomed Opt 14(2):024031, 2009

18. Rajaram N, Nguyen TH, Tunnell JW. A Lookup-table based inverse model for measuring optical properties of turbid media. J Biomed Opt 13(5): 050501, 2008

19. Diagaradjane P, Shetty A, Wang J, Elliot A, Schwartz J, Shentu S, Park HC, Deorukhkar A, Stafford J, Cho S, Tunnell JW, Hazle J, Krishnan S. Modulation of in vivo tumor radiation response via vascular-focused hyperthermia – characterizing gold nanoshells as integrated anti-hypoxic and localized vascular disrupting agent. Nano Lett 8(5); 1492-1500, 2008

20. Park J, Estrada A, Sharp K, Sang K, Schwartz JA, Smith D, Coleman C, Payne JD, Korgel B, Dunn AK, Tunnell JW. Two-photon-induced photoluminescence imaging of tumors using near-infrared excited gold nanoshells. Opt Express 16(3):1590-1599, 2008 (also appeared in Virtual Journal of Biomedical Optics, 3(3), 2008)

21. Zaman RT, Diagaradjane P, Wang J, Schwartz JA, Rajaram N, Gill-Sharp K, Cho S, Rylander HG, Payne DJ, Krishnan S, Tunnell JW. In vivo detection of gold nanoshells in tumors using diffuse optical spectroscopy. IEEE J Sel Top Quant Elec 13(6):1715-1720, 2007

22. Yu CC, Lau C, Tunnell JW, Hunter M, Kalashnikov M, Fang-Yen C, Fulghum SF, Badizadegan K, Dasari RR, Feld MS. Assessing epithelial cell nuclear morphology using azimuthal light scattering spectroscopy. Opt Lett 31(21):3119-3121, 2006

23. Pikkula BM, Tunnell JW, Chang DW, Anvari B. Effects of droplet velocity, diameter, and film height on heat removal during cryogen spray cooling. Ann Biomed Eng 32(8):1131-1140, 2004

24. Tunnell JW, Desjardins A, Galindo L, Georgakoudi I, McGee SA, Mirkovic J, Muller M, Nazemi J, Nguyen FT, Wax A, Zhang Q, Dasari RR, Feld MS. Instrumentation for multimodal spectroscopic diagnosis of epithelial dysplasia. Technol Cancer Res Treat 2(6):505-514, 2003

25. Dai T, Pikkula BM, Tunnell JW, Chang D, Anvari B. Thermal response of human skin epidermis to 595-nm laser irradiation at high incident dosages and long pulse durations in conjunction with cryogen spray cooling: an ex-vivo study. Lasers Surg Med 33(1):16-24, 2003

26. Tunnell JW, Chang D, Johnston C, Torres JH, Patrick CW, Miller MJ, Thomsen SL, Anvari B. Effects of cryogen spray cooling and high radiant exposures on selective vascular injury during laser irradiation of human skin. Arch Dermatol 139:743-750, 2003

(Editorial Review: Anderson RR. Fire and Ice. Arch Dermatol 139:787-788, 2003)

27. Tunnell JW, Wang L, Anvari B. Optimum pulse duration and radiant exposure for vascular laser therapy of dark port-wine stain skin: a theoretical study. Applied Optics 42(7):1367-1378, 2003

28. Pikkula BM, Tunnell JW, Anvari B. Methodology for characterizing heat removal mechanism in human skin during cryogen spray cooling. Ann Biomed Eng 31:493-504, 2003


29. Tunnell JW, Torres JH, Anvari B. Methodology for estimation of time-dependent surface heat flux due to cryogen spray cooling. Ann Biomed Eng 30:19-33, 2002

30. Pikkula BM, Torres JH, Tunnell JW, Anvari B. Cryogen spray cooling: implications of droplet size and spray density on heat removal. Lasers Surg Med 28:103-112, 2001

31. Torres JH, Tunnell JW, Pikkula BM, Anvari B. An analysis of heat removal during cryogen spray cooling and effects of simultaneous airflow application. Lasers Surg Med 28:477-486, 2001

32. Tunnell JW, Nelson JS, Torres JH, Anvari B. Epidermal protection with cryogen spray cooling during high fluence pulsed dye laser irradiation: an ex vivo study. Lasers Surg Med 27(4):373-383, 2000

REFEREED CONFERENCE PROCEEDINGS 1. Wang Y, Bish S, Tunnell JW, and Zhang XJ. MEMS-enabled hyperspectral imaging system for fast CTC

screening. Proc SPIE (in press), 2012

2. Bish S, Wang Y, Tunnell JW, and Zhang XJ, MEMS based handheld functional fast hyperspectral imaging system. The 16th International Conference on Solid-State Sensors, Actuators and Microsystems, June 5-9, 2011, Beijing, China

3. Park J, Estrada A, Sharp K, Sang K, Schwartz JA, Smith DK, Diagaradjane P, Krishnan S, Payne JD, Coleman CL, Korgel BA, Dunn AK, Tunnell JW. Two-photon-induced photoluminescence imaging of gold nanoshell tumor bio-distribution. Proc SPIE 71920T:1-9, 2009

4. Puvanakrishnan P, Park JS, Diagaradjane P, Schwartz JA, Coleman CL, Sharp KL, Sang K, Payne JD, Krishnan S, Tunnell JW. Narrowband imaging of tumors using gold nanoshells. Proc SPIE 716912:1-8, 2009

5. Rajaram N, Kovacic D, Migden MF, Reichenberg J, Nguyen T, Tunnell JW. In vivo spectral analysis of skin cancer. Proc SPIE 7161, 716102-1, 2009

6. Zaman RT, Rylander III HG, Rajaram N, Wang T, Asokan N, Tunnell JW, Welch AJ. Morphological and optical properties changes of sclera due to hyper-osmotic agent. Proc SPIE 71750D:1-10, 2009

7. Tunnell JW, Park J, Estrada A, Sharp K, Sang K, Wang J, Schwartz JA, Coleman C, Payne JD, Dunn AK. Microscopy of gold nanoshells in tumors using two-photon induced photoluminescence. 2008 Digest of the LEOS Summer Topical Meetings, p71-72, 2008

8. Park J, Estrada A, Schwartz JA, Payne JD, Dunn AK, Tunnell JW. 3D Microscopy of gold nanoshells in tumors using two-photon induced photoluminescence. Proc SPIE 6869, 68690L, 2008

9. Rajaram N, Aramil T, Lee K, Tunnell JW. A clinical instrument for spectral diagnosis of cutaneous malignancy. Proc SPIE 6848, 68480R, 2008

10. Diagaradjane P, Shetty A, Wang J, Schwartz J, Shentu S, Park CH, Deorukhar A, Elliot AM, Stafford JR, Cho S, Tunnell JW, Hazle J, Krishnan S. Gold nanoshell mediated hyperthermia enhances the efficacy of radiation therapy. Proc SPIE 6865, 68650N, 2008

11. Dai T, Tunnell JW, Pikkula BM, Chang DW, Anvari B. Thermal response of human skin epidermis to 595 nm laser irradiation and cryogen spray cooling: an ex vivo study. Proc. SPIE, 4949:1-9, 2003

12. Tunnell JW, Wang LH, Anvari B. Increased radiant exposures for cutaneous laser therapy: a mathematical model based on histology. Proc. IEEE-EMBS, 2273-2274, 2002

13. Pikkula BM, Tunnell JW, Anvari B. Methodology for estimating instantaneous heat removal from human skin in response to cryogen spray cooling. Proc. IEEE-EMBS, 2275-2276, 2002

14. Dai T, Tunnell JW, Pikkula BM, Anvari B. High incident fluence and long pulse laser irradiation in conjunction with cryogen spray cooling: an ex-vivo study. Proc. IEEE-EMBS, 2271-2272, 2002

15. Tunnell JW, Stern RA, Pope KA. RF non-ablative cutaneous thermal therapy. Proc. SPIE, 4609, 75-81, 2002

16. Tunnell JW, Chang D, Johnston C, Torres JH, Patrick CW, Miller MJ, Thomsen SL, Anvari B. In vivo study of epidermal protection by cryogen spray cooling during pulsed laser irradiation at high radiant exposures. Proc. SPIE 4609, 67-74, 2002

17. Pikkula BM, Domankevitz Y, Tunnell JW, and Anvari B. Cryogen spray cooling: effects of cryogen film on light transmission and heat removal. Proc. SPIE, 4609, 50-56, 2002


18. Tunnell JW, Torres JH, Anvari B. Estimation of surface heat flux due to cryogen spray cooling using an inverse heart transfer formulation. Bioengineering Conference ASME BED-Vol. 50:125-126, 2001

19. Pikkula BM, Tunnell JW, Torres JH, Anvari B. Mechanism of heat removal for cryogen spray cooling. Bioengineering Conference ASME BED-Vol. 50:121-122, 2001

20. Anvari B, Pikkula BM, Tunnell JW, and Torres JH. Thermal and fluid characteristics during cryogen spray cooling. Proc. SPIE, 4244: 105-112, 2001

REVIEW ARTICLES

1. Wallace MB, Sullivan D, Rustgi AK, Tunnell JW, and Feld MS. Advanced Imaging and Technology in

Gastrointestinal Neoplasia: Summary of the AGA-NCI Symposium. Gastroenterology 130(4):1333-1342, 2006

2. Tunnell JW, Haka AS, McGee SA, Mirkovic J, Feld MS. Diagnostic tissue spectroscopy and its applications to gastrointestinal endoscopy. Tech Gastrointestinal Endo 5:65-73, 2003

BOOKS/BOOK CHAPTERS 1. Pattani V, Tunnell JW. “Optical imaging of plasmonic nanoparticles.” Cancer Nanotechnology: Principles and

Applications in Radiation Oncology Taylor & Francis Group, (in prep.) 2011

2. Tunnell JW. Ed. “Biophotonics Series: In vivo clinical imaging and diagnostics” McGraw-Hill, New York, 2011

3. Erickson T, Tunnell JW. “Gold Nanoshells in Biomedical Applications.” Nanomaterials for the Life Sciences: Mixed metal nanomaterials, Vol. 3 Ed. Chulla Kumar, Wiley-VCH, pgs. 1-44, 2009


PATENTS 1. Tunnell JW, Puvanakrishnan P, Park JS, Payne D. “Narrowband imaging using near infrared absorbing

nanoparticles.” Joint with Nanospectra Biosciences Inc., International App. No.: PCT/US2009/01736 (Licensed to Nanospectra Biosciences Inc. Houston, TX)

2. Tunnell JW, Rajaram N. “Systems and Methods for diagnosis of epithelial lesions” U.S. Provisional Pat. App. Serial No. 61/089,736 August 18, 2008 (Licensed to DermDx, Fresno, CA)

3. Tunnell JW, Zaman R. “Method for measuring metal nanoparticles in tissue.” U.S. Provisional Pat. App. Serial No. 60/944,309 June 15, 2007(U.S. Pat. App. Serial No. 12/139,620 and PCT filed 6/2008) (Licensed to NanoTox Inc., Austin, TX)

4. Bish S, Tunnell JW.”Noncontact spectroscopic probe for tissue characterization” U.S. Provisional App. (filed 4/12/10)

INVITED PRESENTATIONS 1. Tunnell JW. Commercializing Biophotonics devices. Technology Entrepreneurship Seminar Series. University

of Texas at Austin, Austin, TX, September 30, 2011

2. Tunnell JW. Nanoparticle based imaging and treatment of cancer. Symposium on Nanobiophotonics, CLEO: QELS – Fundamental Science, Baltimore, MD, May 1-6, 2011

3. Tunnell JW. Spatial frequency domain imaging of tissues. 2nd Annual DLP Applications and Technology Symposium. AT&T Conference Center. University of Texas at Austin, Austin, TX, April 23, 2010

4. Tunnell JW. Cutting Edge technologies in tumor margin detection. Annual meeting of the American Society for Laser Medicine and Surgery. Phoenix, AZ, April 17, 2010

5. Tunnell JW. Optical nanotechnology for the combined imaging and treatment of cancer. Invited talk - 93rd Annual meeting of the Optical Society of America, Frontiers in Optics. San Jose, CA, October 11-15th, 2009

6. Tunnell JW. Optical nanotechnology for the combined imaging and treatment of cancer. Seminar –

Department of Biomedical Engineering. University of California, Irvine, CA, May 14th, 2009 7. Tunnell JW. The symbiotic relationship between marine scientists and biomedical engineers: the noninvasive

detection of skin cancer. Seminar – Harte Research Institute. Texas A&M University, Corpus Christi, TX, May 8th, 2009

8. Tunnell JW. Biophotonics in cancer detection and treatment. Seminar - Department of Biomedical

Engineering. Texas A&M University, College Station, TX, April 13th, 2009

9. Tunnell JW. Spectral diagnosis of skin cancer. Enabling Breakthrough in Medical Electronics. Texas Life-Science Collaboration. Texas State University, Round Rock, TX, March 11, 2009

10. Tunnell JW. Spectral diagnosis of cutaneous malignancy. Translating Medical and Biological Engineering:

Bringing Technologies to Life. Annual Event for the American Institute for Medical and Biological Engineering (AIMBE). National Academy of Sciences, Washington, DC, February 11th, 2009

11. Tunnell JW. Biophotonics in cancer detection and treatment. Seminar - Department of Biomedical

Engineering. Rice University, Houston, TX, November 4th, 2008 12. Park J, Estrada A, Schwartz JA, Payne JD, Dunn AK, Tunnell JW. Microscopy of gold nanoshells in tumors

using two-photon induced photoluminescence. IEEE LEOS. Acapulco, Mexico, July 21-23, 2008 13. Tunnell JW. Optical strategies for detection, targeting and treatment of cancer. NSF IGERT Seminar, The

University of Texas at Austin, Austin, TX February 15, 2008


14. Tunnell JW. Opportunities for biomedical engineering in world health. UT for REED (Rural Enhancement through Education and Design), The University of Texas at Austin, Austin, TX, September 24, 2007

15. Tunnell JW. Monitoring metal nanoparticles in vivo. Advances in Oncology Institutional Grand Rounds. MD

Anderson Cancer Center, Houston, TX, July 13, 2007 16. Tunnell JW. Thermoradiotherapy – Development and validation of a new paradigm in cancer therapeutics.

Annual Biomedical Engineering Conference – UT Center for Biomedical Engineering. MD Anderson Cancer Center, Houston, TX, December 12, 2006

17. Tunnell JW. Optical strategies for detection, targeting and treatment of cancer. NSF IGERT Seminar, The

University of Texas at Austin, Austin, TX December 1st, 2006 18. Tunnell JW. Detection of dysplasia and metaplasia in the esophagus using optical spectroscopy. Annual

Biomedical Engineering Conference – UT Center for Biomedical Engineering. MD Anderson Cancer Center, Houston, TX, December 12-13, 2005

19. Tunnell JW. Real-time multi-modal optical spectroscopy for early cancer detection. Engineering Conferences

International – Advances in Optics for Biotechnology, Medicine, and Surgery. Copper Mountain, CO, July 24-28, 2005

20. Tunnell JW. Real-time spectral diagnosis of precancer. 4th International Cervical Cancer Meeting. MD

Anderson Cancer Center, Houston, TX, May 19-22, 2005 21. Tunnell JW. Real-time detection of dysplasia in patients with Barrett’s esophagus. Lester Wolfe Workshop in

Laser Biomedicine – Optical Imaging of Pre-cancer in the Esophagus, Massachusetts General Hospital, Cambridge, MA, April 12, 2005

22. Tunnell JW and Feld MS. Spectroscopic imaging of colon dysplasia. NIH/AGA Symposium on Advanced

Imaging and Technology in Gastrointestinal Neoplasia. Bethesda, MD, October 4-5, 2004

23. Tunnell JW and Feld MS. Spectroscopy, fluorescence imaging, and reflectance imaging. NIH/AGA Symposium on Advanced Imaging and Technology in Gastrointestinal Neoplasia. Bethesda, MD, October 4-5, 2004

24. Tunnell JW, Desjardins A, McGee SA, Mirkovic J, Nazemi J, Badizadegan K, Dasari RR, Feld MS. Real-time in vivo diagnosis of epithelial precancer using multimodal optical spectroscopy. Great Lakes Photonics Symposium. Cleveland, OH, June 7-11, 2004

INVITED WORKSHOPS The Academy of Medicine, Engineering, & Science of Texas, Annual Meeting, Austin, TX Jan. 6-7, 2011 Wallace H. Coulter Foundation – Coulter College, Ft. Lauderdale, FL August 9-11, 2010 Wallace H. Coulter Foundation – Coulter College, Ft. Lauderdale, FL August 10-12, 2009 American Institute for Medical and Biological Engineers, Annual Event, Washington, DC Feb. 11-13, 2009 Wallace H. Coulter Foundation – Coulter College, Ft. Lauderdale, FL August 4-7, 2008 Protégé – The Academy of Medicine, Engineering, & Science of Texas, Annual Meeting, Houston, TX Jan.

10-11, 2008 Wallace H. Coulter Foundation Early Career Awardee Workshop, Miami, FL August 15-16, 2007 Wallace H. Coulter Foundation Early Career Awardee Workshop, Chicago, October 11, 2006


SELECTED PRESENTATIONS 1. Mereck S, Lichtey W, Tunnell JW. Controlled Drug Delivery from Alginate Spheres in Design-Based Learning

Course. Annual Meeting of the American Society for Engineering Education, San Antonio, TX June 10-13, 2012

2. Bish S, Wang Y, Zhang J, Tunnell JW. Diffuse reflectance imaging system for spatial mapping of tissue optical properties. SPIE International Symposium on Biomedical Optics, San Jose, CA January 21-26, 2012

3. Lim L, Nichols B, Rajaram N, Reichenberg J, Migden M, Tunnell JW. Clinical study for spectral diagnosis of in vivo melanoma and non-melanoma skin cancer diagnosis. SPIE International Symposium on Biomedical Optics, San Jose, CA January 21-26, 2012

4. Wang Y, Bish S, Tunnell JW, and Zhang XJ. MEMS-enabled hyperspectral imaging system for fast CTC screening. SPIE International Symposium on Biomedical Optics, San Jose, CA January 21-26, 2012

5. Puvanakrishnan P, Diagaradjane P, Schwartz JA, Krishnan S, Tunnell JW. Targeted gold nanorods as probes for EGFR-overexpression in squamous cell carcinomas. Biomedical Engineering Society Annual Meeting, Hartford, CT October 11-15, 2011

6. Lim L, Nichols B, Rajaram N, Reichenberg J, Migden M, Tunnell JW. Clinical, Non-invasive in vivo Diagnosis of Melanoma Skin Cancer using Multimodal Spectral Diagnosis (SD). Biomedical Engineering Society Annual Meeting, Hartford, CT October 11-15, 2011

7. Barman I, Dingari NC, Rajaram N, Tunnell JW, Dasari RR, Feld MS. Enhanced Optical Property

Determination in Biological Tissues using a Non-Linear Calibration Framework. FACSS Conference, Reno, NV, October 2-7, 2011

8. Nichols B, Rajaram N, Tunnell JW. Performance of a look-up table based inverse model for steady state diffuse optical spectroscopy. Engineering Conferences International, Advances in Optics for Biotechnology, Medicine, and Surgery XII, Naples, FL, June 5-9, 2011

9. Pattani V, Tunnell JW. A comparative study of photothermal heating efficiency of gold nanoshells and nanorods. Engineering Conferences International, Advances in Optics for Biotechnology, Medicine, and Surgery XII, Naples, FL, June 5-9, 2011

10. Bish S, Tunnell JW. Non-Contact Diffuse Reflectance Probe with a DMD Spatial Filter for Tunable Collection Geometries. Engineering Conferences International, Advances in Optics for Biotechnology, Medicine, and Surgery XII, Naples, FL, June 5-9, 2011

11. Lim L, Nichols B, Migden M, Reichenberg J, Tunnell JW. Clinical Study for Spectral Diagnosis of in vivo Melanoma and Non-Melanoma Skin Cancer Diagnosis. Engineering Conferences International, Advances in Optics for Biotechnology, Medicine, and Surgery XII, Naples, FL, June 5-9, 2011

12. Puvanakrishnan P, Park J, Diagaradjane P, Goodrich GP, Schwartz JA, Krishnan S, Tunnell JW. Real-time near-infrared narrow band imaging of tumors using gold nanoparticles. Engineering Conferences International, Advances in Optics for Biotechnology, Medicine, and Surgery XII, Naples, FL, June 5-9, 2011

13. Rajaram N, Reichenberg JR, Tunnell JW. Pilot clinical study for non-invasive diagnosis of non-melanoma skin cancer. 69th Annual Meeting of the American Academy of Dermatology, New Orleans, LA, February 4-8, 2011

14. Puvanakrishnan P, Park J, Diagaradjane P, Goodrich GP, Schwartz JA, Krishnan S, Tunnell JW. In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy. Annual meeting of the American Society for Laser Medicine and Surgery. Grapevine, TX, April 1-3, 2011

15. Puvanakrishnan P, Diagaradjane P, Goodrich GP, Schwartz JA, Krishnan S, Tunnell JW. Narrowband

imaging of targeted gold nanorods in tumors. Annual meeting of the American Society for Laser Medicine and Surgery. Grapevine, TX, April 1-3, 2011


16. Zaman R, Oliver J, Welch AJ, Tunnell JW, Rylander HG, Signal variation of fluorescein dye in anterior

chamber and vitreous eye. Annual meeting of the American Society for Laser Medicine and Surgery. Grapevine, TX, April 1-3, 2011

17. Bish S, Wang Y, Tunnell JW, and Zhang XJ, MEMS based handheld functional fast hyperspectral imaging system. The 16th International Conference on Solid-State Sensors, Actuators and Microsystems, June 5-9, 2011, Beijing, China

18. Bish S, Wang Y, Zhang XJ, Tunnell JW. MEMS Based Hyperspectral Imaging System Towards Imaging of Biological Tissue. Biomedical Engineering Society Annual Meeting, Austin, TX October 6-9, 2010

19. Puvanakrishnan P, Park J, Diagaradjane P, Goodrich GP, Krishnan K, Tunnell JW. Wide-Field Near-Infrared Narrow Band Imaging of Gold Nanoparticles’ Distribution in Tumors. Biomedical Engineering Society Annual Meeting, Austin, TX October 6-9, 2010

20. Puvanakrishnan P, Bosch M, Hessel C, Rasch M, Korgel B, Tunnell JW. Uptake of Polymer Coated Silicon

Nanocrystals in Cancer Cells. Biomedical Engineering Society Annual Meeting, Austin, TX October 6-9, 2010 21. Wang Y, Bish S, Gopal A, Tunnell JW, Zhang XJ. MEMS Scanner Enabled Real-Time Depth Sensitive

Hyperspectral Imaging. 2010 International Conference on Optical MEMS and Nanophotonics, Sapporo, Japan August 9-12, 2010

22. Rajaram N, Reichenberg J, Tunnell JW. Spectral diagnosis of skin cancer. Central Texas Clinical Research Forum, Austin, TX, May 7, 2010

23. Lim L, Rajaram R, Nichols B, Tunnell JW. Time resolved study of probe pressure effects on skin fluorescence and reflectance spectroscopy measurements. OSA Biomedical Optical Spectroscopy and Diagnostics. Miami, FL, April 11-14, 2010

24. Erickson T, Tunnell JW. An empirical method for imaging optical properties with structured illumination beyond the diffusion regime. OSA Biomedical Optical Spectroscopy and Diagnostics. Miami, FL, April 11-14, 2010

25. Bish S, Tunnell JW. Development of a noncontact probe for diffuse optical spectroscopy of skin. OSA Biomedical Optical Spectroscopy and Diagnostics. Miami, FL, April 11-14, 2010

26. Sun J, Rajaram N, Migden M, Reichenberg JS, Tunnell JW. Parametric and empirical spectral analysis for non-invasive diagnosis of basal cell carcinoma. OSA Biomedical Optical Spectroscopy and Diagnostics. Miami, FL, April 11-14, 2010

27. Rajaram N, Migden M, Reichenberg JS, Nguyen T, Tunnell JW. Pilot clinical study for quantitative spectral diagnosis of non-melanoma skin cancer. OSA Biomedical Optical Spectroscopy and Diagnostics. Miami, FL, April 11-14, 2010

28. Pattani V, Campbell M, Tunnell JW. Nanoparticle-mediated photothermal therapy of tumors: a comparative study of photothermal efficiency for different particle types. Annual meeting of the American Society for Laser Medicine and Surgery. Phoenix, AZ, April 17, 2010

29. Rajaram N, Nichols BS, Reichenberg JS, Tunnell JW. Diffuse optical spectroscopy for the diagnosis of skin cancer: an optimized lookup table based model for determining tissue optical properties. Annual meeting of the American Society for Laser Medicine and Surgery. Phoenix, AZ, April 17, 2010

30. Nichols BS, Rajaram N, Tunnell JW. Optimization of a look-up table model adept in extracting optical properties of tissue. Biomedical Engineering Society 2009 Annual Meeting, Pittsburg, PA, October 7-10, 2009

31. Rajaram N, Kovacic D, Migden MR, Reichenberg JS, Nguyen TH, Tunnell JW, Clinical Spectral Diagnosis of Non-Melanoma Skin Cancer: Initial Pilot Study. European Conferences on Biomedical Optics. Munich, Germany, June 14-18, 2009


32. Rajaram N, Gopal A, Zhang XJ, Tunnell JW. Spectral diagnosis of cutaneous malignancy: effect of pigment

packaging on diffuse reflectance measurements. 29th Annual Meeting for the American Society for Laser Medicine and Surgery, Washington, DC, April 1-5, 2009

33. Park J, Estrada A, Sharp K, Sang K, Schwartz JA, Smith DK, Diagaradjane P, Coleman C, Payne JD, Krishnan S, Korgel BA, Dunn AK, Tunnell JW. Investigation of gold nanoparticle transport kinetics using two-photon induced photoluminescence imaging. 29th Annual Meeting for the American Society for Laser Medicine and Surgery, Washington, DC, April 1-5, 2009

34. Zaman R, Rajaram N, Walsh A, Oliver J, Rylander HG, Tunnell JW, Welch AJ, Mahadevan-Jansen A.

Variation of fluorescence with temperature. 29th Annual Meeting for the American Society for Laser Medicine and Surgery, Washington, DC, April 1-5, 2009

35. Park J, Estrada A, Schwartz JA, Payne JD, Dunn AK, Tunnell JW. Two photon microscopy of gold

nanoparticles bio-distribution in tumors. SPIE International Symposium on Biomedical Optics, San Jose, CA January 24-29, 2009

36. Puvanakrishnan P, Diagaradjane P, Schwartz J, Payne D, Krishnan S, Tunnell JW. Narrowband imaging of

tumors using gold nanoshells. SPIE International Symposium on Biomedical Optics, San Jose, CA January 24-29, 2009

37. Rajaram N, Kovacic D, Migden MF, Reichenberg J, Nguyen T, Tunnell JW. In vivo spectral analysis of skin

cancer. SPIE International Symposium on Biomedical Optics, San Jose, CA January 24-29, 2009 38. Zaman RT, Rylander III HG, Rajaramn N, Wang T, Asokan N, Tunnell JW, Welch AJ. Morphological and

optical properties changes of sclera due to hyper-osmotic agent. SPIE International Symposium on Biomedical Optics, San Jose, CA January 24-29, 2009

39. Suggs LJ, Tunnell JW, Diller K, Crawford R. Implementing Redesign in the BME Senior Capstone Experience.

ASEE Annual Conference, Pittsburgh, PA June 22-25, 2008 40. Park J, Estrada A, Schwartz JA, Payne JD, Dunn AK, Tunnell JW. Microscopy of gold nanoshells in tumors

using two-photon induced photoluminescence. Conference on Lasers and Electro-optics (CLEO). San Jose, CA, May 2-9, 2008

41. Reichenberg J, Kovacic D, Rajaram N, Nguyen T, Tunnel JW. Spectral Diagnosis of cutaneous malignancy.

Central Texas Clinical Research Forum. Austin, TX, May 9, 2008 42. Rajaram N, Tunnell JW. A look-up table based inverse model for measuring tissue optical properties. OSA

Biomedical Optical Spectroscopy and Diagnostics. St. Petersburg, FL, March 16-19, 2008 43. Feld MS, Lau C, Scepanovic O, McGee SA, Mircovic J, Yu CC, Fulghum S, Tunnell JW, Backman V,

Georgakoudi I, and Bechtel K. The Role of Light Scattering Spectroscopy in Spectral Diagnosis of Disease. OSA Biomedical Optical Spectroscopy and Diagnostics. St. Petersburg, FL, March 16-19, 2008

44. Rajaram N, Tunnell JW. A look-up table based inverse model for measuring tissue optical properties. Houston

Society for Engineering in Medicine and Biology (HSEMB). Houston, TX, February 7-8, 2008 45. Rajaram N, Tunnell JW. Determining the optical properties of turbid media using a LUT-based inverse model.

Lasers in Modern Biology and Medicine – AJ Welch Symposium. Austin, TX, January 28-29, 2008 46. Park J, Estrada A, Schwartz JA, Payne JD, Dunn AK, Tunnell JW. 3D Microscopy of gold nanoshells in

tumors using two-photon induced photoluminescence. SPIE International Symposium on Biomedical Optics: Plasmonics in Biology and Medicine V, San Jose, CA January 19-24, 2008

47. Rajaram N, Aramil T, Lee K, Tunnell JW. A clinical instrument for spectral diagnosis of cutaneous malignancy.

SPIE International Symposium on Biomedical Optics: Advanced Clinical and Diagnostic Systems VI, San Jose, CA January 19-24, 2008


48. Diagaradjane P, Shetty A, Wang J, Schwartz J, Shentu S, Park CH, Deorukhar A, Elliot AM, Stafford JR, Cho

S, Tunnell JW, Hazle J, Krishnan S. Gold nanoshell mediated hyperthermia enhances the efficacy of radiation therapy. SPIE International Symposium on Biomedical Optics: Plasmonics in Biology and Medicine V, San Jose, CA January 19-24, 2008

49. Park J, Rajaram N, Tunnell JW. Combined fluorescence and reflectance hyperspectral imaging for cancer

detection. Advances in Optics for Biotechnology, Medicine and Surgery – Engineering Conferences International, Naples, Florida June 10-14, 2007

50. Rajaram N, Aramil T, Lee K, Tunnell JW. A clinical spectrometer for early detection of cutaneous malignancy.

Advances in Optics for Biotechnology, Medicine and Surgery – Engineering Conferences International, Naples, Florida June 10-14, 2007

51. Zaman R, Diagaradjane P, Krishnan S, Tunnell JW. Measuring gold nanoparticle concentrations in tissue

using diffuse optical spectroscopy. Conference on Lasers and Electro-optics (CLEO). Baltimore, MD, May 6-11, 2007

52. Aramil TJ, Lee K, Rajaram N, Tunnell JW. A clinical spectrometer for the spectral diagnosis of cutaneous

melanoma. Houston Society for Engineering in Medicine and Biology (HSEMB). Houston, TX, February 8-9, 2007

53. Rasoulian M, Voss J, Revia R, Zaman R, Smith DK, Korgel BA, Tunnell JW. Structured illumination

tomography using gold nanoparticle contrast agents. Houston Society for Engineering in Medicine and Biology (HSEMB). Houston, TX, February 8-9, 2007

54. Park J, Tunnell JW. Combined fluorescence and reflectance hyperspectral imaging for in vivo cancer

detection. Houston Society for Engineering in Medicine and Biology (HSEMB). Houston, TX, February 8-9, 2007

55. Rajaram N, Dagani GT, Fakhoury JR, Zhang X, Tunnell JW. Effect of inhomogeneous distribution of

chromophores on diffuse reflectance measurements in tissue. Houston Society for Engineering in Medicine and Biology (HSEMB). Houston, TX, February 8-9, 2007

56. Zaman R, Schwartz J, Wang J, Diagaradjane P, Krishnan S, Tunnell JW. Measuring gold nanoparticle

concentrations in tissue using diffuse optical spectroscopy. Houston Society for Engineering in Medicine and Biology (HSEMB). Houston, TX, February 8-9, 2007

57. Kornguth S, Sessler J, Tunnell JW, Digiovanni J, Dudley JP, Kornguth D, Emelianov S. 3T magnetic

resonance, photoacoustic, and elasticity imaging of tumors in mice. Cambridge Health Institute: Imaging Week, In Vivo Molecular Imaging, La Jolla, CA. November 14-15, 2006

58. Yu CC, Lau C, Tunnell JW, Hunter M, Kalashnikov M, Fang-Yen C, Fulghum SF, Badizadegan K, Dasari RR,

Feld MS. Assessing epithelial cell nuclear morphology with azimuthal light scattering spectroscopy. OSA Biomedical Optical Spectroscopy and Diagnostics. Ft. Lauderdale, FL, March 19-22, 2006

59. Wallace MB, Tunnell JW, Jost C, Lewin D, Wildi S, Badizadegan K, Galindo L, McGee S, Mirkovic J, Nazemi

J, Dasari RR, Feld MS. Real-time optical detection of dysplasia in Barrett’s esophagus using tri-modal (diffuse reflectance, fluorescence, light-scattering) spectroscopy. American Gastroenterological Association – Digestive Disease Week 2005. Chicago, IL May 14-19, 2005

60. Tunnell JW, Desjardins A, McGee SA, Mirkovic J, Nazemi J, Dasari RR, Feld MS. Effects of epithelial nuclear

size and density on elastic scattering spectroscopy: an experimental study using two-layer tissue phantoms. OSA Biomedical Optical Spectroscopy and Diagnostics. Miami, FL, April 14-17, 2004

61. Tunnell JW, Wang LH, Anvari B. Increased radiant exposures for cutaneous laser therapy: a mathematical model based on histology. 2nd Joint Meeting of the IEEE-EMBS/BMES. Houston, TX, October 23-26, 2002


62. Pikkula BM, Tunnell JW, Anvari B. Methodology for estimating instantaneous heat removal from human skin in response to cryogen spray cooling. 2nd Joint Meeting of the IEEE-EMBS/BMES. Houston, TX, October 23-26, 2002

63. Dai T, Tunnell JW, Pikkula BM, Anvari B. High incident fluence and long pulse laser irradiation in conjunction with cryogen spray cooling: an ex-vivo study. 2nd Joint Meeting of the IEEE-EMBS/BMES. Houston, TX, October 23-26, 2002

64. Pope KA, Tunnell JW. Radio frequency energy delivery to the skin: computer model with contact cooling and histology. 22nd Annual Meeting for American Society for Laser Surgery and Medicine. Atlanta, GA, April 10-14, 2002

65. Tunnell JW, Wang L, Anvari B. Protecting human skin epidermis with cryogen spray cooling during laser therapy: comparisons between mathematical model and histological results. 22nd Annual Meeting for American Society for Laser Surgery and Medicine. Atlanta, GA, April 10-14, 2002

66. Pikkula BM, Tunnell JW, Anvari B. Cryogen spray cooling: effect of droplet velocity on heat removal. 22nd Annual Meeting for American Society for Laser Surgery and Medicine. Atlanta, GA, April 10-14, 2002

67. Tunnell JW, Stern RA, Pope KA. Capacitive RF electrode for non-ablative cutaneous thermal therapy. SPIE International Symposium on Biomedical Optics: Cutaneous Applications of Lasers: Dermatology and Plastic Surgery. San Jose, CA, January 19-25, 2002

68. Tunnell JW, Chang D, Johnston C, Torres JH, Patrick CW, Miller MJ, Anvari B. In-vivo study of epidermal protection by cryogen spray cooling during high fluence laser irradiation. SPIE International Symposium on Biomedical Optics: Cutaneous Applications of Lasers: Dermatology and Plastic Surgery. San Jose, CA, January 19-25, 2002

69. Tunnell JW, Torres JH, Milner TE, Anvari B. Skin thermal response to cryogen spray cooling using and inverse heat transfer formulation. 21st Annual Meeting for American Society for Laser Surgery and Medicine. New Orleans, LA, April 18-22, 2001

70. Tunnell JW, Chang D, Johnston C, Torres JH, Patrick CW, Miller MJ, Anvari B. Epidermal protection during high fluence laser irradiation using cryogen spray cooling: and in vivo study. Nineteenth Annual Houston Conference on Biomedical Engineering Research. Houston, TX, February 8-9, 2001

71. Tunnell JW, Torres JH, Anvari B. High fluence dermatological laser surgery using cryogen spray cooling. Optical Society of America Annual Meeting. Providence, RI, October 22-26, 2000

72. Tunnell JW, Nelson JS, Torres JH, Anvari B. Epidermal protection with cryogen spray cooling during high fluence pulsed dye laser irradiation: an ex vivo study. 20th Annual Meeting for American Society for Laser Surgery and Medicine, Reno, NV, April 7-9, 2000

73. Tunnell JW, Nelson JS, Torres JH, Anvari B. Protecting human epidermis from high fluence pulsed dye laser irradiation with cryogen spray cooling: an ex vivo study. Eighteenth Annual Houston Conference on Biomedical Engineering Research. Houston, TX, February 10-11, 2000


TEACHING EXPERIENCE My teaching activities at the University of Texas have centered on teaching five biomedical engineering courses at the undergraduate and graduate level: four already taught and one under development. The four courses I have taught include BME303 Introduction to Computing for Biomedical Engineers (enrollment ~100), BME301 Biotechnology and World Health (enrollment ~40), BME 370 Principles of Engineering Design (enrollment ~90), and BME 377T/381J Fundamentals of Biomedical Optics (enrollment ~30). While I adapted BME 301, 303, and 370 from existing course, I developed BME377T/381J as a new course. In addition, I am currently developing BME102L Fundamentals of Engineering Design to be taught for the first time in the Fall 2010. This laboratory course serves as a hands-on introduction to engineering design for first year BME students. I received academic development funds to support this development. Finally, I have been actively involved in the curriculum planning of BME’s lab courses (BME 102L, 221, 251, 370), and I serve as the supervising faculty for BME251 Biomedical Engineering Image and Signal Processing Laboratory. Academic Development Academic Development Funds, Cockrell School of Engineering, University of Texas at Austin - “Development of first-year design lab for Biomedical Engineering”, $11,883 Instructional Workshops National Effective Teaching Institute – American Society for Engineering Education (ASEE), Louisville, KY, June 17-19, 2010 Instructor (Fall 2010, Fall 2011): BME102L – Introduction to Biomedical Engineering Design Principles, The University of Texas at Austin, Austin, TX Faculty Supervisor (Spring 2010, Spring 2011): BME251 – Biomedical Engineering Image and Signal Processing Laboratory (Instructor: Bobby Knight), The University of Texas at Austin, Austin, TX Instructor (Spring 2009, Spring 2010, Spring 2011): BME377T/BME381J – Fundamentals of Biomedical Optics, The University of Texas at Austin, Austin, TX Instructor (Spring 2008): BME381J.1 – Laser-Tissue Interactions, The University of Texas at Austin, Austin, TX Instructor (Fall 2007, Fall 2008): BME370 – Principles of Engineering Design for Biomedical Engineers, The University of Texas at Austin, Austin, TX Instructor (Spring 2006, Spring 2007): BME301 – Biotechnology and World Health, The University of Texas at Austin, Austin, TX Instructor (Fall 2005, Fall 2006): BME303 - Introduction to Computing Systems for Biomedical Engineers, The University of Texas at Austin, Austin, TX Guest Lecturer (Spring 2006, 2007): BME314 Engineering Foundations of BME, University of Texas at Austin, Austin, TX Guest Lecturer (Fall 2007): Nanomedicine, “NIR metal nanoparticles for imaging and therapy in oncology, University of Texas at Austin, Austin, TX and MD Anderson Cancer Center, Houston, TX Guest Lecturer (Spring 2006, 2007, 2008): BME251 Biomedical Engineering Laboratory, University of Texas at Austin, Austin, TX Guest Lecturer (Spring 2008, Spring 2009, Spring 2010): BME301 – Biotechnology and World Health, The University of Texas at Austin, Austin, TX


STUDENT RELATED SERVICE PhD Supervisions Completed: Narasimhan Rajaram, Biomedical Engineering, UT Austin, 2010 Dr. Rajaram is now a postdoctoral fellow at Duke University, Durham, NC. Jaesook Park, Biomedical Engineering, UT Austin, 2010 Dr. Park is now a postdoctoral fellow at Asan Medical Center, Seoul, Korea. MS Supervisions Completed: Raiyan Zaman, M.S., Electrical and Computer Engineering, UT Austin, 2006 Priyaveena Puvanakrishnan, M.S., Biomedical Engineering, UT Austin, 2009 Tim Erickson, MS, Biomedical Engineering, 2009 Varun Patanni, M.S., Biomedical Engineering, UT Austin, 2010 PhD Students (Current): Priyaveena Puvanakrishnan, PhD student (candidacy 4/10), Biomedical Engineering, 2007 – present Varun Patanni, Ph.D. student, Biomedical Engineering, 2008 – present Sam Lim, Ph.D. student, Biomedical Engineering, 2008 – present Sheldon Bish, Ph.D. student, Biomedical Engineering, 2008 - present Bin Yang, Ph.D. student, Biomedical Engineering, 2010 - present Student Awards (Univ. of Texas): Narasimhan Rajaram – Newport-Spectra Physics Research Excellence Award, SPIE San Jose, CA 2008 Priyaveena Puvanakrishnan – Newport-Spectra Physics Research Exc. Award, SPIE San Jose, CA 2009 Jaesook Park – Travel Grant, Engineering Conferences International, 2007 Narasimhan Rajaram – Travel Grant, Engineering Conferences International, 2007 Jaesook Park – ASLMS 2008 student research grant - $5000 grant Narasimhan Rajaram - ASLMS 2008 student research grant - $5000 grant Jaesook Park – Newport-Spectra Physics Research Excellence Award, SPIE San Jose, CA 2008 Brandon Nichols – Undergraduate Research Fellowship, UT Cooperative Society, 2008-2009, $1000 Priyaveena Puvanakrishnan – ASLMS 2009 student research grant - $5000 grant Narasimhan Rajaram - Graduate Student Professional Development Award - $400, UT BME, 2009 Brandon Nichols – 2009 SPIE Scholarship in Optical Science and Engineering, SPIE, 2009, $2000 Narasimhan Rajaram - Graduate Student Travel Award - $125, UT CSE, 2009 Varun Pattani - USAF Grant for Graduate Students and Post-Doctoral Fellows Currently Involved Full-Time in

Biomedical Laser Research, 2010 - $1,000 Varun Pattani – Best Basic Science Paper (Student/Resident) – Am. Soc. for Laser Medicine & Surgery, 2010 David Chau – Undergraduate CPRIT Fellowship - $5000, 2010 Matthew Bosch – Undergraduate Research Fellowship, University of Texas, $948, 2010 Priyaveena Puvanakrishnan – “Hot Topics Invited Talk”, Engineering Conferences International, $500, 2011 Priyaveena Puvanakrishnan – “Graduate Student Award”, Biomedical Engineering Society, 2011 Priyaveena Puvanakrishnan – 2nd place, Proctor and Gamble Seminar Competition, $500, 2011

Dissertation Committee: Bo Chen, Ph.D. (2007), Biomedical Engineering; AJ Welch, Chair Francis Tseng, Ph.D. (2007), Electrical and Computer Engineering; Yale Patt, Chair Chris Hoy, M.S. (2007), Mechanical Engineering; Adela Ben-Yakar, Chair Chris Hoy, Ph.D. (candidacy 7/2008), Mechanical Engineering; Adela Ben-Yakar, Chair Nick Durr, Ph.D. (candidacy 5/2008), Biomedical Engineering; Adela Ben-Yakar, Chair Kimberly Homan, Ph.D. (candidacy 5/2008), Biomedical Engineering; Stanislav Emelianov, Chair Eric Spivey, Ph.D. (candidacy 2/2009), Biomedical Engineering; Andrew Dunn/Jason Shear, co-Chairs Arnold Estrada, Ph.D. (candidacy 3/2009), Biomedical Engineering; Andrew Dunn, Chair Aswhin Parthasarathy, Ph.D. (candidacy 3/2009), Biomedical Engineering; Andrew Dunn, Chair Adrien Ponticorvo, Ph.D. (candidacy 3/2009), Biomedical Engineering; Andrew Dunn, Chair Jinze Qiu, Ph.D. (candidacy 10/2009) Biomedical Engineering; Thomas Milner, Chair Jinyang Liang, Ph.D. (candidacy 10/2009), Electrical and Computer Engineering; Michael Becker, Chair


Undergraduate Advising: Tim Aramil, B.S. 2007, Biomedical Engineering (F2005 - SP2007) Kelvin Lee, B.S. 2007, Biomedical Engineering (F2005 - SP2007) Jennifer Voss, B.S. student, Biomedical Engineering (SP2006 – F2007) Michael Rasoulian, B.S. student, Biomedical Engineering (SP2006 – F2007) Dat Le, B.S. student, Biomedical Engineering (SP2006 – F2007) Ted Yang, B.S. student, Biomedical Engineering (SP2006 – SP2008) Richard Revia, B.S. student, Biomedical Engineering (SP2006 – F2007) Colby Anger, B.S. student, BME (SP2007 – F2007) Matt Campbell, B.S. student, BME (SP2006 – SP2009), UT Southwestern Medical School, 2009 Jason Yiu, B.S. student, BME (F2008) Jared McAllister, B.S. student, BME (F2008), Washington Univ. Medical School 2010 Brandon Nichols, B.S. student, BME (F2008 – S2011, Duke University, PhD in BME) Matthew Bosch, B.S. student, BME (F2009 – SP2011, Rice University, MS in BME) David Chau, B.S. student, BME (SP2010 – SP2011) Joseph N Nayigiziki, B.S. student, BME (SP2010 – SP2011) Ernest Puckett, B.S. student, BME (SP2010 – SP2011)

David Do, B.S. student, BME (F2011 - Present) Matthew Liu, B.S. student, BME (SP2011 - F2011) Evan Luther, B.S. student, BME (F2010 - SP2010) Jerin Jose, B.S. student, BME (S2011-present) Whiney Wang, B.S. student, BME (S2011-present) Dereck Ho, B.S. student, BME (S2011) Alexandra Atalis, B.S. student, BME (SP2011 – present) Anirudh Sharma, B.S. student, BME (F2011 – present)

BME371 - Senior Project Design Team (Spring 2006, 2007, 2009, 2010, 2011)

2011-2012: Christopher Albert, Frederick Caberto, Utsab Das, Dominic Nguyen. Improvments for a visually impaired walking cane.

2011-2012: NSF REU2007 – Matthew Huddle (Weslayan University, MN) summer 2007 NSF REU2008 – Jessica Gamboa (University of Arizona), summer 2008 Plan II Honors Mentor – Undergraduate

Plan II Honors mentor, Spring 2008 – Huram Mok Plan II Honors mentor, Spring 2008 – Haley Kensing


UNIVERSITY SERVICE Administrative Undergraduate Faculty Advisor, 2011 – present

University Committees Institutional Animal Care and Use Committee (IACUC), UT-Austin, Fall 2009 - present Nanoscience and Nanotechnology Doctoral Portfolio Program, Advisory Committee, 2010-present Graduate Assembly, Admissions and Enrollment Committee, 2011 - 2012 Graduate Assembly, Administrative Committee, 2010 - 2011 CSE Engineering Honors Committee, 2005-2006, 2009-2010, 2010-2011 CSE Public Affairs Advisory Committee, 2008-2009 CSE Staff Excellence Awards Committee, Spring 2008 BME GSC Executive Committee, 2011–2012 BME Graduate Admissions Committee, 2006-present BME Safety committee, 2009-2010 BME Undergraduate Curriculum Committee, Fall 2009 – present BME Adjunct/Adjoint Appointment Committee, Spring 2009 - present

Student Organizations Faculty Sponsor: Univ. of Texas for REED – Rural Enhancement through Engineering & Design, 2007–pres. Faculty Sponsor: Biomedical Optics Graduate Organization (BOGO) – (SPIE student chapter), 2008 – pres. Participation: “Lunch with an Engineer”, Women in Engineering Program (WEP) – University of Texas at

Austin – (2006, 2007, 2009, 2010) Fireside Chat: University of Texas Biomedical Engineering Society (BMES) – Spring 2007, Spring 2008 Fireside Chat: University of Texas, Tau Beta Pi – Spring 2006 Reviewer: Graduate & Industry Networking (GAIN) Conference, Univ. of Texas at Austin, February 21, 2007 Lecture: UT Open House – Univ. of Texas at Austin: “Detecting and Treating Cancer with Light”, Spring 2008 Lecture: Women in Engineering (WEP) – Consider Every Option (CEO) – University of Texas at Austin

“Detecting and Treating Cancer with Light”, June 17, 2008 Lecture: Women in Engineering (WEP) – Design Your World (DYW) – University of Texas at Austin

“Detecting and Treating Cancer with Light”, July 25, 2008 Lecture: Women in Engineering (WEP) – Consider Every Option (CEO) – University of Texas at Austin

“Detecting and Treating Cancer with Light”, June 9, 2009 Lecture: CSE Engineering Honors Seminar and Luncheon – University of Texas, Feb. 21, 2009 Reviewer: Graduate & Industry Networking (GAIN) Conference, Univ. of Texas at Austin, February 27, 2009 Lecture: UT Open House – Univ. of Texas at Austin: “Detecting and Treating Cancer with Light”, Spring 2009 Lecture: “Detecting and Treating Cancer with Light”, BIO102C, University of Texas, March 23, 2009 Panel Discussion – “ASEE Professor Panel - The Top Five Things You Wish You Had Known About Being a

New Faculty Member”, Am. Soc. Eng. Edu., April 15, 2009 Lecture: “Detecting and Treating Cancer with Light”, Beta Mu Epsilon (BME Honors Society), University of

Texas, September 16, 2009 Lecture: Women in Engineering (WEP) – Consider Every Option (CEO) – University of Texas at Austin

“Detecting and Treating Cancer with Light”, June 11, 2010 Participation: Lunch with Equal Opportunity in Engineering (EOE) Longhorn Program – University of Texas at

Austin, September 17, 2011


PROFESSIONAL SERVICE Editorial Boards Associate Editor – Annals of Biomedical Engineering, 2010-present

State Level Boards 2011 Tuning Oversight Council for Engineering and Science (TOCES), Texas Higher Education Coordinating

Board Professional Society/Conference Organization General Chair – Engineering Conferences International, Advances in Optics and Biotechnology, Medicine,

and Surgery XIII, 2013 Co-director – “How to Use Optical Diagnostics in Clinical Laser Medicine” course, American Society for Laser

Medicine and Surgery, Annual Conference, 2011 Program Chair - CLEO-Applications, 2011 Program Committee – “Clinical and Biomedical Spectroscopy” – European Conference of Biomedical Optics

(ECBO), Munich, Germany, 22-27 May 2011 Chair, Molecular Probes and Nanobio-optics Technical Group, Optical Society of America, 2011-2013 Research and Development Committee, Am. Soc. for Laser Medicine & Surgery, 2010-2013 Program Committee – Biophotonics Conference, IEEE Photonics Society 23rd Annual Meeting, Denver, CO

Nov. 7-11, 2010 Program Committee – CLEO-Applications, 2010 (inaugural committee board) Technical Program Co-Chair – Biomedical Engineering Society Annual Meeting, Austin, TX, September, 2010 Program Committee – Biophotonics Conference, IEEE Photonics Society 22nd Annual Meeting, Belek-

Antalya, Turkey, Oct. 4-8, 2009 Chair – Subcommittee on Biological and Medical Applications, CLEO (Conference on Lasers and Electro-

Optics), Baltimore, MA, May 29 – June 5, 2009 Program Committee – IEEE LEOS (Laser and Electro-Optics Society) 21st Annual Meeting, Newport Beach,

CA, Nov. 9-13, 2008 Program Committee - IEEE LEOS (Lasers and Electro-Optics Society) Summer Topicals 2008 “Next Frontiers

in Optical Communications, Optofluidics & Advanced Nanobiophotonics” Acapulco, Mexico July 21-23, 2008 Program Committee, Subcommittee on Biological and Medical Applications, CLEO (Conference on Lasers

and Electro-Optics), San Jose, CA May 2-9, 2008 Program Committee, CLEO (Conference on Lasers and Electro-Optics), Baltimore, MD May 6-11, 2007 Program Committee, OSA Topical Meeting on Biomedical Optics, Ft. Lauderdale, FL April 14-17, 2004

Conference Session Chair “Biomedical Tomography”, CLEO (Conf. on Lasers & Electro-Optics), Baltimore, MD May 31 - June 5, 2009 “Advanced Biophotonics Nanoscopy”, IEEE LEOS (Lasers and Electro-Optics Society) Summer Topicals

2008 “Next Frontiers in Optical Communications, Optofluidics and Advanced Nanobiophotonics” Acapulco, Mexico July 21-23, 2008

“Nanoparticles & Molecular Approaches for Biosensing”, CLEO (Conf. on Lasers &Electro-Optics), San Jose, CA May 2-9, 2008

“Deep Tissue Imaging”, CLEO (Conference on Lasers and Electro-Optics), San Jose, CA May 2-9, 2008 “Nanoparticles and Rheology”, CLEO (Conf. on Lasers & Electro-Optics), Baltimore, MD May 6-11, 2007 “Cellular Imaging”, CLEO (Conference on Lasers and Electro-Optics), Baltimore, MD May 6-11, 2007

Professional Memberships Fellow, American Society for Laser Medicine and Surgery (ASLMS) Optical Society of America (OSA) The International Society for Optical Engineers (SPIE) IEEE Engineering in Medicine and Biology (IEEE-EMBS) IEEE Photonics Society (IEEE-LEOS) Biomedical Engineering Society (BMES) American Society for Engineering Education (ASEE)

Reviewer NIH – ICMIC Review Panel, 2011 NIH – Challenge Grants (RC1), 2009


NIH – Small Business Biomedical Imaging (ZRG1 SBMI-F (11) (B) October 27, 2005 NIH – Special Emphasis Panel/Scientific Review Group 2009/10 ZRG1 BST-M (58) R July 20, 2009 Journal Peer Review: PNAS, J Biomed Opt, Opt Lett, Lasers Surg Med, Appl Opt, Ann Biomed Eng, J

Nanopart Res, Crit Rev Biomed Eng, IEEE Trans Biomed Eng, J Opt Soc Am A, Opt Exp, Photochem Photobiol, Phys Med Biol, IEEE J Sel Top Quant Elect, Tissue Engineering

Book Review: Cambridge University Press

James W. Tunnell - Department of Biomedical Engineering

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