McGinty v. Zuckerberg, Sandberg - class action complaint.pdf
Jacqueline F. McGinty, Timothy W. Whitfield Jr., William J. Berglind.
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Transcript of Jacqueline F. McGinty, Timothy W. Whitfield Jr., William J. Berglind.
Jacqueline F. McGinty, Timothy W. Whitfield Jr., William J. Berglind
Chronic neurobiological disorder Detrimental effects Compulsive behavior Preoccupation
Neurological Development: Increased drug-seeking behavior Attenuation of other behaviors
Reward Pathway Learning Key areas
Cognition Goals Many connections
Executive Function Decision making Troubleshooting Novel / Dangerous / Difficult situations Overcoming strong habitual response
Neuroadaptations TrkB
Plasticity Behavioral coping Neuroprotection Associative learning
Increased BDNF Production NAc
NAc expression: Behavioral
sensitization CPP
Kristy R. Crooks, Daniel T. Kleven, Ramona M. Rodriguiz, William C. Wetsel, James O. McNamarae,
+ pTrkB in Nac dnTrkB mice
Tet-off system
bdnf
P!Cascade to mRNA
Normal TrkBdnTrkB bdn
f
No P Occurs!
DOX TAKEN FROM DIET!
TrkB expression: Sensitization CPP Feeds reward
pathway
Increased BDNF Production PFC
attenuation
PFC BDNF < drug induced NAc GLU levels
PFC BDNF normalizes NAc p-ERK
Fabio Fumagalli, Lucia Caffino, Giorgio Racagni, Marco Andrea Riva,
Chronic stress: Sensitizes behavioral
response Facilitates
reinstatement Affects BDNF
expression
Chronically stressed male rats acute cocaine
BDNF & TrkB PFC Hippocampus
Stressed rats : Restraint swim tests No habituation
BDNF neuroprotection reward pathway
BDNF Site specific use Protect executive functioning