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Jacqueline F. McGinty, Ph.D. Interim Dean, College of Graduate Studies NIDA T32 Director Dept. of Neuroscience and Neurobiology of Addiction Research Center Medical University of South Carolina Career Development in Translational Addiction Research

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Career Development in Drug Abuse Research Predoctoral T32->F30/F31 Postdoctoral T32->F32 K Awards NIDA Mentored Clinical Scientists Development Program Award in Drug Abuse and Addiction (K12) PAR- 13-163 (K12) - March 28, 2013 PAR- 13-163 (K12) - March 28, 2013 NIH Pathway to Independence Award (Parent K99/R00) PA-14-042 (K99/R00) - December 19, 2013 PA-14-042 (K99/R00) - December 19, 2013 Mentored Quantitative Research Development Award (Parent K25) PA-14-048 (K25) - December 19, 2013 PA-14-048 (K25) - December 19, 2013 Mentored Patient-Oriented Research Career Development Award (Parent K23) PA-14-049 (K23) - December 19, 2013 PA-14-049 (K23) - December 19, 2013 Mentored Clinical Scientist Research Career Development Award (Parent K08) PA-14-046 (K08) - December 19, 2013 PA-14-046 (K08) - December 19, 2013 Mentored Research Scientist Development Award (Parent K01) PA-14-044 (K01) - December 19, 2013 PA-14-044 (K01) - December 19, 2013 Independent Scientist Award (Parent K02) PA-14-045 (K02) - December 19, 2013 http://www.drugabuse.gov/funding/research-training-career-development http://report.nih.gov/nihdatabook/index.aspx?catid=14 Fellows on NRSA grants, compared with their colleagues without NRSA support, are more likely to be appointed as faculty and more likely to apply for and receive independent NIH support. NIDA Mentoring Guide

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Kirschstein-NRSA pre-doctoral fellowships (F31) Competing applications, awards, and success rates

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Kirschstein-NRSA post-doctoral fellowships (F32) Competing applications, awards, and success rates

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Research Career Development Awards

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Research Career Development Award Success Rates

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http://www.drugabuse.gov/publications/mentoring-guide-drug-abuse-researchers/preface "NIDA offers a strategic set of funding mechanisms to support the development of research scientists through various stages of their careers. These awards are designed to ensure that scientists of the very highest caliber will be available in adequate numbers and in the appropriate research areas and fields to meet the Nation's drug abuse and addiction needs." Nora D. Volkow, M.D., NIDA Director The guide was developed over several years with the help of both mentors and mentees. Work began at a workshop of the College on Problems of Drug Dependence (CPDD) in 2003, continued at a career development seminar of CPDD in 2005, and culminated at the National Institute on Drug Abuse (NIDA) Research Training Institute in 2006. NIDA Mentoring Guide

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NIDA Strategic Plan 2016-2020 The current NIDA Strategic Plan was published in 2010. Since that time, there have been major advances in the science of drug abuse and addiction. In the Strategic Plan for 20162020, NIDA seeks to harness the latest research technologies and apply them to the ever-evolving substance abuse landscape. Toward this goal, NIDA staff developed a draft set of strategic priorities and are seeking feedback to guide the development of NIDAs Strategic Plan. See more at: http://grants.nih.gov/grants/guide/notice- files/NOT-DA-15-005.html#sthash.UuANcvIX.dpuf

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NIDA Strategic Priorities 2016-2020 Increase our knowledge of biological, behavioral, environmental, and developmental factors involved in risk and resilience for drug use and addiction Integrating animal models, behavior, genetics, epigenetics, and other molecular biomarkers for drug abuse and addiction Understand the developmental trajectory of addiction and individual heterogeneity Improve our understanding of brain circuits related to drug abuse and addiction at the cellular, circuit, and connectome levels, including: Normal development and function across the lifespan including mechanisms of reward, self- control, and conditioning Drug effects on neuroplasticity, neural structure, and circuit function across the stages of addiction Neurobiological correlates of recovery Neural-glial, -immune, and neuroendocrine interactions Better define the interactions between addiction and pain, including molecular, genetic, behavioral, and neural-circuit-related factors, to guide the development of alternate treatment strategies for pain patients Improve our understanding of the interaction between addiction and co-occurring conditions Elucidate the impact of mental health, HIV, HCV, pain, etc. on addiction; Understand molecular mechanisms of latent HIV reservoirs in the brains of substance-abusing populations Basic Neuroscience: Improve our understanding of the basic science of drug use, addiction, vulnerability to addiction, and recovery See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-DA-15- 005.html#sthash.UuANcvIX.dpuf

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NIDA Strategic Priorities 2016-2020 Support the development of novel, evidence-based, targeted prevention and treatment interventions including social, behavioral, pharmacological, vaccines, and brain stimulation therapies (e.g., transcranial magnetic stimulation, direct current stimulation, etc.) Accelerate the identification of promising targets and ligands to accelerate new drug discovery and development Accelerate medications development for SUDs Focused development efforts on: Addictions without an FDA approved treatment Detoxification Overdose prevention or reversal Accelerating neurobiological recovery Addressing comorbidities (MH, HIV, HCV, pain) Develop techniques to measure and improve patient compliance in clinical trials Identify measures other than abstinence that can reliably assess SUD treatment outcomes Identify biomarkers of addiction, resilience, and recovery to enable personalized treatment Clinical and Translational Science: Support the development of new and better interventions and treatments that incorporate the diverse needs of individuals with Substance Use Disorders (SUDs) See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-DA-15- 005.html#sthash.UuANcvIX.dpuf

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NEED FOR TEAM SCIENCE: Approaches from single disciplines have done much to advance drug abuse research, but technological, methodological, and other advances have established the need for increasingly multidisciplinary approaches to address more complex questions. DIVERSITY: The demographics of students and mentees are changing continually. As the demographic characteristics of mentees shift, so must the training of mentors. NOT-OD-15-053 http://grants.nih.gov/grants/guide/notice-files/NOT-OD-15- 053.html Release Date: January 12, 2015 Purpose http://grants.nih.gov/grants/guide/notice-files/NOT-OD-15- 053.html The purpose of this notice is to provide an updated diversity statement that describes NIH's interest in the diversity of the NIH-funded workforce. NIDA Strategic Plan 2016-2020

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Trends in race/ethnicity of NIH-supported Ph.D. recipients White Asian/Pacific Islander Hispanic Black

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BIOMEDICAL RESEARCH WORKFORCE WORKING GROUP REPORT National Institutes of Health June 14, 2012

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US Graduate Degrees Awarded, by Field Basic Biomedical MDs

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Years Biomedical PhDs Spend in Postdoctoral Training Most US-trained biomedical PhDs spend fewer than 5 years in postdoctoral positions, although that number has been grown since 2003

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Biomedical Postdoctoral Researchers by Type of Support

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Age at First PhD, First Non Postdoctoral Job, First Tenure Track Job, for US trained Doctorates First PhD First non-postdoc Job First tenure-track Job

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Distribution of NIH RPG Principal Investigators by Degree Type Researchers with an MD or MD/PhD comprise around 30% of NIH-funded Principal Investigators (PIs). The percentage of MDs has declined and the percentage of MD/PhDs has increased slightly in the past few years. PhD MD MD/ PhD

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Estimated Change in Employment Levels in Biomedical Occupations Medical Scientists Postsecondary Teachers Biological Scientists Biochemists Survey of Doctorate Recipients

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Biomedical PhD Job Stats

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McGinty Lab http://academicdepartments.musc.edu/neuro-research/research/lab/McGinty_Lab/index.html