Jackie Oldham - MIMIT

Joining forces to identify and address unmet clinical need through technology innovation

Copyright 2009 Property of MIMIT

1st International Affiliate of

1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

A Center at

VA Boston

2009 2010

International Affiliates

CIMIT: A formal consortium among 13 Boston institutions, MIMIT and A*Star Singapore

http://www.ehponline.org/docs/2002/110p1051-1055devine/vabost.jpg



Joining Forces to Transform Healthcare

Drive innovation on the basis of unmet clinical need

Create technology innovation partnerships

Leverage of investment



MIMITTM - Innovation Development Pathway

Project Proposals

Industry Engagement

MIMIT Funding

Site Miner dialogue with

clinical community

Clinical Unmet Need

Industry targeted

scoping or other

introduction

Dissemination of need

To the widest group of scientists, engineers and designers.

Validation of need

Projectaward

Forum

Optional Industry

Funding or involvement

Best Ideas

Six month review Facilitated

Grant Funding

Other

Unmet Need Market Analysis Integration of need and solution Project DeliveryLicense/spin

out/other

Operational/ Management

team

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–Outputs• Identification and dissemination of existing

technology solutions• 22 unmet healthcare needs pump-primed• 3x leverage on initial investment (after 1 year)• Enhanced industry liaison opportunity• Longer term – patents / VC funding / licence

agreement / royalties– 1 project licence agreement and £5m VC funding

• Translational research opportunity / research outputs

• Optimised partnership opportunity



MIMIT workshops

MIMIT: CIMIT

Science Bridges award

Science Bridge Connections

University of Manchester

UHSM

CMFT Adults

CMFT Children’s

Tissue Engineering

Chemical Eng & cardiovascular Med

Pharmacy / biomaterials

Mathematics

The Christie

Wolfson Molecular Imaging/ neurology

Rehab Science

Plastic surgery

Respiratory medicine

Biomedical imaging

ENT

Anaesthetics

Paediatric oncology

Paediatric ICU

Neurology

Neonatology

Terenghi

Yuan

El-deredy

Parker

Lionheart

McCann

Oldham

McGrouther

Woodcock

Fowler

Herholz

Homer

Coleman

Makin

Playfor

Martland

Tirelli

Psychological Sciences

Electrical Eng.

Victor

MIT

Harvard Medical School

Draper Lab

Boston University

Brigham Women’s

Massachusetts General

Boston Children’s

Tissue EngineeringGuttag

Biomed Engineering

Radiology

Neurology

Biomedical Engineering

Rehabilitation Services

Pathology & Health Sciences

Laryngeal Surgery and Voice Rehab

Anaesthetics

Paediatric ICU

Grinstaff

Kikinis

Schacter

Trevejo

Borenstein

Zaman

Stevenson

Schoen

Hillman

Goldman

Wolf

Gaydecki

SRFTAdult ICU Dark

MIMIT workshops

Joint AHSC collaboration (via TTO’s) •Hospital Acquired Infection collaboration with the National Innovation Centre •Enhancing functional independence collaboration with Arthritis Research UK and the National Innovation Centre



Need unique to

organisation

Unmet need identified By 2-3 organisations

Universal unmet need

Retain exclusive rights to

innovate towards locally

Shared unmet needs with co rights to innovate to in collaboration

Scope unmet needs in agreed areas of mutual interest:Low probability of need

being universal

High probability of need

being universal •Collaboration to select preferred innovation target•Competition to find best solutions•Progress through jointly awarded funding initiatives or independently



‘Demand led’ opportunities:– Benefits to patients and clinicians by definition and

validation of unmet healthcare needs and a commitment to develop innovative solutions

– Best potential for development of good solutions by a wide scoping of expertise amongst organisations

– Best chance for success by selection of best projects

– Optimised leverage of investment to support innovation developments



The outputs:• World wide patents granted• SME collaboration FEMEDA• UMIP & TRUSTECH facilitated

licence agreement• >£5million venture capital

funded• Phase IV study complete• Global company expressions of

interest• >£200k industry sponsored

research funding• Bionow Healthcare Project of

the Year 2010• Sales commencing 2013

The need: Solving stress incontinence

The solution: Novel ‘tampon like’ pelvic floor muscle stimulator



The outputs:• Funding leveraged £627k

including EPSRC and Williamson Trust

• Numerous conference presentations

• High impact publications• Patent protected• PhD studentships

awarded

The need: Reducing histopathological subjectivity in determining prostatic malignancy

The solution: Objective spectroscoping grading system for prostate cancer biopsies



The outputs:• Patent filed • Funding leveraged £595k

including Medical Futures grant, NIHR i4i, UMIP PoP

• Numerous high impact publications

• PhD studentship funded (Newby Trust)

• Clinical trials underway

The need: Surgical repair of severed peripheral nerves

The solution: Novel fabricated polymer peripheral nerve conduits



The outputs:• Novel microgel and

testing models developed• Funding leveraged £215k

(EPSRC)• PhD studentship• Patent protected• Numerous high impact

publications

The need: Replacement for degenerate intervertebral discs to treat low back pain

The solution: New biomaterials for regeneration of degenerate intevertebral disc



The outputs:• Prototype developed &

undergoing clinical evaluation • Funding leveraged £664k

(Wellcome Trust, EPSRC, UMIP, MIMIT Science Bridges)

• UMIP PoP funding awarded• Patents filed and granted (UK,

EU & US) • Numerous publications &

international conference presentations / plenary

The need: Treatment for chronic pain hampered by lack of knowledge of the brains' response (fEITER)

The solution: Real time pain assessment using electrical impedance tomography (EIT)



The outputs:• Patents filed• UMIP PoP funding

awarded £80k • RCUK Science Bridges

award £100k• Industry collaboration

The need: Point of care testing for respiratory disease

The solution: Novel breath collection device and identification of pathogen specific biomarkers

2008



The outputs:• Prototype developed• Clinical testing underway• Further support from

TRUSTECH• Funding leveraged £43k

MRC Interdisciplinary Award

The need: Difficult to monitor compliance with knee exercises in the home

The solution: Compliance monitoring device



The outputs:• Collaboration established

with Boston Children’s Hospital

• £50k Science Bridges award

• Animal studies underway

The need: Reducing ventilator-associated lung injury

The solution: Continuous non-invasive image guidance at the bedside



The outputs:• Collaboration established with

Harvard Medical School / Brigham & Women’s and £50k Science Bridges award

• UK collaboration with Imperial College London and the Walton Centre NHS Foundation Trust, Liverpool

• £603k funding leveraged including Astro Fund

• Tracer markers identified & absract accepted British Neuro-oncology Society Annual meeting 2012

•

The need: Difficult to visualise glioma tumour margins when operating

The solution: Using PET and diffusion weighted MRI in the operating room to facilitate glioma tumour management



The outputs:• Collaboration established

with Harvard Medical School & Brigham & Women’s,

• £100k Science Bridges award made

• Phantom studies complete

• Ethical approval for human pilot granted

The need: Difficulty with functional imaging of the lung

The solution: Fusion of EIT and MRI data of the lung



Acknowledgments

Manchester Academic Health Science Centre (MAHSC)

National Innovation Centre



1st International Affiliate of

Jackie Oldham - MIMIT

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