IVMS Intro to Biochemistry Lecture 13 -Protein
86
Gkjhmolkstry 18 NOBOWAD SWKBHKSDOX Srjtokb 1 Sroparoe abe prosobtoe gy Larh Klmjtop Hray, L.E. Gaskh Loekhad Xhkobhos & H@ U oahmor Woforobho rosjurhos9 Jrnabkh hmolkstry Gkjhmolkstry‘^k`kpoeka Srjtokb-^k`kpoeka
-
Upload
marc-imhotep-cray-md -
Category
Documents
-
view
214 -
download
0
Transcript of IVMS Intro to Biochemistry Lecture 13 -Protein
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 1/86
Gkjhmolkstry 18NOBOWAD SWKBHKSDOX
Srjtokb
1
Sroparoe abe prosobtoe gy
Larh Klmjtop Hray, L.E.Gaskh Loekhad Xhkobhos & H@ Uoahmor
Woforobho rosjurhos9
Jrnabkh hmolkstry Gkjhmolkstry‘^k`kpoeka Srjtokb-^k`kpoeka
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 2/86
7
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 3/86
8
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 4/86
5
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 5/86
?
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 6/86
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 7/86
>
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 8/86
=
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 9/86
;
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 10/86
13
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 11/86
11
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 12/86
17
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 13/86
18
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 14/86
15
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 15/86
1?
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 16/86
16
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 17/86
1>
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 18/86
1=
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 19/86
1;
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 20/86
73
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 21/86
71
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 22/86
77
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 23/86
78
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 24/86
75
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 25/86
7?
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 26/86
76
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 27/86
7>
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 28/86
7=
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 29/86
7;
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 30/86
83
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 31/86
81
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 32/86
87
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 33/86
88
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 34/86
85
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 35/86
8?
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 36/86
86
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 37/86
8>
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 38/86
8=
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 39/86
8;
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 40/86
53
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 41/86
51
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 42/86
57
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 43/86
58
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 44/86
55
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 45/86
5?
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 46/86
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 47/86
5>
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 48/86
5=
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 49/86
5;
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 50/86
?3
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 51/86
?1
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 52/86
?7
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 53/86
?8
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 54/86
?5
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 55/86
??
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 56/86
?6
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 57/86
?>
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 58/86
?=
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 59/86
?;
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 60/86
63
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 61/86
61
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 62/86
67
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 63/86
68
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 64/86
65
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 65/86
6?
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 66/86
66
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 67/86
6>
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 68/86
6=
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 69/86
6;
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 70/86
Xullary
>3
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 71/86
Umo Alkbj Ahkes. Add prjtokbs aro pjdylorsjf alkbj ahkes, wmkhm aro gkfubhtkjbad jrnabkhhjlpjubes tmat hjbtakb gjtm ab alkbj nrjupabe a hargjxydato nrjup. Ekfforobhos kb tmo W
nrjups jf alkbj ahkes hauso ekfforobhos kb tmoprjportkos jf alkbj ahkes abe prjtokbs. Ywkttorkjbs. Umo prosobho jf gjtm alkbj
nrjups abe hargjxyd nrjups kb alkbj ahkesla`os kt pjsskgdo fjr alkbj ahkes tj oxkst kbsovorad kjbkh fjrls, kbhduekbn tmo fjrl jf azwkttorkjb. Umo zwkttorkjb ks a ekpjdar fjrl kbwmkhm tmo bot hmarno jb tmo kjb ks zorj.
Woahtkjb jf Alkbj Ahkes. Alkbj ahkes habubeornj roahtkjbs hmarahtorkstkh jf abyfubhtkjbad nrjup kb tmo ljdohudo. Uwjroahtkjbs jf klpjrtabho aro tmo roahtkjb jftwj hystokbo ljdohudos tj fjrl a ek sudfkeo,
abe tmo roahtkjb jf alkbj nrjups abehargjxydato nrjups jf ekfforobt ljdohudos tjfjrl poptkeo (alkeo) dkb`anos.
>1
K S ke L m 733
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 72/86
Klpjrtabt Soptkeos. Ljro tmab 733poptkeos mavo goob smjwb tj go ossobtkad tjtmo prjpor fubhtkjbkbn jf tmo mulab gjey.Mjrljbos abe ob`opmadkbs aro aljbn tmopoptkeos fjr wmkhm fubhtkjbs mavo goobkeobtkfkoe.
Hmarahtorkstkhs jf Srjtokbs. Srjtokbs arodarno pjdylors jf alkbj ahkes. Ahkekh abegaskh prjportkos jf prjtokbs aro eotorlkboe gytmo ahkekh jr gaskh hmarahtor jf tmo W nrjupsjf tmo alkbj ahkes hjlprkskbn tmo prjtokb.Srjtokbs porfjrl bulorjus klpjrtabt
fubhtkjbs kb tmo gjey. Srjtokbs aro hdasskfkoestruhturaddy as fkgrjus jr ndjgudar. Umoy arohdasskfkoe jb tmo gasks jf hjlpjsktkjb assklpdo jr hjbiunatoe.
Umo Srklary Xtruhturo jf Srjtokbs. Umoprklary struhturo jf a prjtokb ks tmo soquobhojf alkbj ahkes kb tmo pjdylorkh hmakb. Umks
nkvos add prjtokbs ab keobtkhad gah`gjbo jfhargjb abe bktrjnob atjls mode tjnotmor gypoptkeo dkb`anos. Umo ekfforobho kb prjtokbs kstmo soquobho jf W nrjups attahmoe tj tmogah`gjbo.
>7
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 73/86
Umo Xohjbeary Xtruhturo jf Srjtokbs. Srjtokb hmakbs aro mode kb hmarahtorkstkh smaposhaddoe sohjbeary struhturos gy myerjnobgjbes. Uwj spohkfkh struhturos tmat mavo goob
keobtkfkoe aro tmo adpma-modkx abe tmo gota-pdoatoe smoot. Umo Uortkary Xtruhturo jf Srjtokbs. A tmkre
dovod jf hjlpdoxkty kb prjtokb struhturo rosudtsfrjl kbtorahtkjbs gotwoob tmo W nrjups jfprjtokb hmakbs. Umoso kbtorahtkjbs kbhdueoeksudfkeo grkenos, sadt grkenos, myerjnobgjbes, abe myerjpmjgkh attrahtkjbs.
Umo Quatorbary Xtruhturo jf Srjtokbs. Xjlo fubhtkjbad prjtokbs hjbskst jf twj jrljro pjdypoptkeo hmakbs mode tjnotmor gyfjrhos suhm as kjbkh attrahtkjbs, eksudfkeogrkenos, myerjnob gjbes, abe myerjpmjgkh
fjrhos. Umo arrabnolobt jf tmoso pjdypoptkeostj fjrl tmo fubhtkjbad prjtokb ks haddoe tmoquatorbary struhturo jf tmo prjtokb.
>8
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 74/86
Srjtokb Myerjdysks abeEobaturatkjb. Umo poptkeo (alkeo)dkb`anos jf poptkeos abe prjtokbs hab
go myerjdyzoe ubeor apprjprkatohjbektkjbs. Umks eostrjys tmo prklarystruhturo abe prjeuhos sladdorpoptkeos jr alkbj ahkes. Umohmarahtorkstkh sohjbeary, tortkary, abe
quatorbary struhturos jf prjtokbs habadsj go eksruptoe gy hortakb pmyskhadjr hmolkhad hjbektkjbs suhm asoxtrolo tolporaturos jr pM vaduos.Umo eksruptkjb jf tmoso struhturos kshaddoe eobaturatkjb, abe hausos tmoprjtokb tj gohjlo bjbfubhtkjbad abe,kb sjlo hasos, tj prohkpktato.
>5
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 75/86
Fjrlatkvo Assosslobt
>?
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 76/86
Uj hroato a prjtokb, alkbjahkes aro dkb`oe vka a(b)
ZZZZ gjbe.alkeoahotadostor
otmorhargjxydkh
>6
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 77/86
alkeo
>>
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 78/86
Umo prjtokb assjhkatoewktm hjbbohtkvo tkssuo
suhm as tobejbs ks9 fkgrjnoblyjskbhjddanob
`oratkb
>=
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 79/86
hjddanob
>;
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 80/86
A prjtokb hab go eobaturoegy wmkhm jf tmo fjddjwkbn.
ahkesgasosmoatadd jf tmo agjvo
=3
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 81/86
add jf tmo agjvo
=1
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 82/86
Fjr tmo oxalpdodkstoe kb Fknuro 7,wmat typo jfstruhturo ks
smjwb: prklarysohjbearytortkary
quatorbary
=7
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 83/86
sohjbeary
=8
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 84/86
Fjr tmo oxalpdo
dkstoe kb Fknuro 8,wmat typo jfstruhturo kssmjwb:
prklarysohjbearytortkaryquartorbary
=5
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 85/86
quartorbary
=?
8/13/2019 IVMS Intro to Biochemistry Lecture 13 -Protein
http://slidepdf.com/reader/full/ivms-intro-to-biochemistry-lecture-13-protein 86/86
Umo obeUmab` yju fjr yjur attobtkjb
Furtmor Xtuey9Gkjhmolkstry abe Hodd GkjdjnyHjddono jf Xakbt Goboekht abe Xakbt Ijmb's _bkvorskty - Gkjhmolkstry Jbdkbo Kbekaba _bkvorskty - Loekhad Gkjhmolkstry Sano LKU - Gkjdjny Myportoxtgjj`
BDL - Gkjhmolkstry BDL - Ljdohudar Hodd Gkjdjny _bkvorskty jf _tam - BotGkjhmol
