IVIG reimbursement in Czech Republic - Ústav imunologie...
Transcript of IVIG reimbursement in Czech Republic - Ústav imunologie...
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IVIG reimbursement in Czech Republic
Anna SedivaInstitute of ImmunologyPrague, Czech Republic
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Czech Republic
history of immunology in Czechoslovakia
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Czech Immunology
"Czech School of Immunology" founded by Milan Hašek, co-discoverer of the immunological tolerance phenomenon.
Gregor Mendelgenetics
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Czech clinical immunology immunodeficiences
First book on immunedeficiences1979
„bubble boy“1980
Prof.Good in Czechoslovakia 1969
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XLA - Bruton agammaglobulinemiacase report history of Czech patients
Dystonia Deafness Protein DDP Mohr-Tranebjaerg syndrome,mitochondrial disease
typical clinical symptomatology of XLA associated with deafness and mentalretardation
exon 19 deletion of BTK deletion of DDP X 22q ‚contiguous deletionsyndrome‘
two brothers with atypical form of XLA
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Diagnosis and therapy in time
1975-1980diagnosis made on clinical picture andlaboratory investigationof humoral immunity
1983-1984first flow cytometer inCzechoslovakiamissing B lymphocytes
1980-1995substitution -plasma or IVIG czecho-slovak production
Allergic reactions, complications. Discontinued in 90´s.
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Diagnosis and therapy in time
2004Patients in USA and Lithuania
1993XLA gene discovery
1995deletion of exon 19
2000 Continuous deletion syndrome2002-2004mitochondrial disease
molecular diagnostics inCzech RepublicESID
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Time, Czechoslovakia and IVIG
1957 IMUNA –plasma fractionationŠarišské Michalany
1945 1968
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Time, Czechoslovakia and IVIG
1989 velvet revolution
socialisticstate directedhealth care system
communism capitalism
gradual development of health insurance
Czech IVIG partly covered European IVIG partly covered
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ESID and European cooperation
IVIGsc immunoglobulins
Diagnostic guidelineswww.esid.org
Therapeutic guidelines
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humoralcellularphagocyticcomplementotherPrimary immunodeficiences
Europe Czech Republic Inst. of Immunology
66%
18%
7%6% 3%
961278%
7%
2%
11% 2%
577
36%
44%
3%
13%4%
118
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IVIG current situation, Czech Republic immunodeficiences
centers for IDexcellent clinical effect
reimbursement policiesfrequent changesuncertainity
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IVIG current situation, Europe immunodeficiences
hospital care out-patient care
Czech Republic covered reimbursement based on fixed sum, problems with new patients
France covered covered
Germany covered if > 24g/dose covered
Greece covered at the moment γ-globulin is not allowed for outpatient care, yet
Hungary covered covered
Netherlands covered insurance company has to approve beforehand, but mostly it is covered
Poland covered covered
Spain covered covered
Sweden covered partly covered home care
United Kingdom covered covered
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IVIG current situation, Czech Republic autoimmunity
Kawasaki diseaseITP
others
1 g 4x1018 molecules IgG
reimbursed on an individual basis
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IVIG current situation, Czech Republic problems
moneyLow immunoglobulins, no infection?Near normal immunoglobulins with infections?Autoimmunity?
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IVIG perspectives
substitution based on therapeutic guidelinesproduction of specific molecular targeted IVIGIVIG in autoimmune diseases
IVIG in cancermolecular technologies in IVIGproductionIVIG production in plantsmucosal immunoglobulins
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