Ivana Pavlinac Dodig, M.D., Ph.D.neuron.mefst.hr/docs/katedre/neuroznanost/Basic... · o C1-C4 =...
Transcript of Ivana Pavlinac Dodig, M.D., Ph.D.neuron.mefst.hr/docs/katedre/neuroznanost/Basic... · o C1-C4 =...
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Ivana Pavlinac Dodig, M.D., Ph.D.
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1. Organization of the CNS 2. Spinal cord 3. Pathways of the spinal cord
1. Long ascending tracts
2. Long descending tracts
4. Spinal cord in cross sections
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Grey Matter = Cell Body
White Matter = Myelinated axon
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Cortex Nucleus (CNS) Ganglion (PNS); exception: Basal Ganglia
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Nerve (PNS) Tract (CNS) Fasciculus/Funiculus = group of fibers with common
origin and destination Lemniscus = ribbon-like fiber tract Peduncle = massive group of fibers (usually several tracts)
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Tracts are named with origin first, then destination Corticobulbar tract
Corticospinal tract
Spinocerebellar tract
Mammilothalamic tract
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Spinal cord is SMALL! 40-45 cm long
1 cm wide at widest point
Does not extend all the way to the bottom of the spinal column
From foramen magnum to intervertebral disc (L1-L2); continues as filum terminale (to sacral canal)
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Pars cervicalis
Pars thoracica
Pars lumbalis
Conus medullaris & filum terminale
Upper 2/3 of the vertebral column
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Pattern of grey/white matter is reversed in the cord White matter tracts on outside
Grey matter on the inside
Staining reverses this!!!
White matter
(tracts of axons)
Grey matter
(cell bodies)
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White matter - funiculi: Dorsal (posterior) Lateral Ventral (anterior)
Gray matter – buterfly shaped – horns:
Anterior Posterior Intermediolateral cell
column (IML)
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Posterior (dorsal) horn Intermediate grey Anterior (ventral) horn
Laminar organisation
Rexed laminae
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Spinal cord is segmented anatomically Input and output occurs in groups of rootlets
arranged in a series longitudinally along the cord
Dorsal rootlets = Input (carry sensory information)
Ventral rootlets = Output (motor neurons)
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Dorsal and ventral roots
Common spinal nerve trunk
(1-2 mm)
Dorsal and ventral ramus
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31 pair of spinal nerves
8 cervical (C1 - C8)
12 Thoracic (T1 - T12)
5 Lumbar (L1 - L5)
5 Sacral (S1 - S5)
1 Coccygeal
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The spinal cord is housed within the vertebral column
Each cord segment has a corresponding vertebra of the same name (e.g., C3)
Spinal nerves enter/exit underneath their corresponding vertebral segment
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But wait! Something doesn’t add up!
How can spinal nerves exit below their corresponding vertebral segment if the cord is only 40cm-45cm long?
Answer: Spinal nerves extend down to the appropriate vertebral segment forming the cauda equina
This means cord segments and vertebral segments don’t line up
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Each set of rootlets forms a spinal nerve that innervates a corresponding segment of
the body
Area of the skin supplied by the right and left dorsal roots of
a single spinal segment.
Overlapping areas!
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Cord is not of uniform thickness throughout its length. Why not?
Answer:
Segments of the cord innervate parts of the body that differ in complexity
There are fewer white matter tracts lower in the cord.
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2 enlargements:
▪ Cervical (C5-T1)
▪ Lumbar (L1-S2)
o C1-C4 = plexus cervicalis
o C5-T1 = plexus brachialis
o L1-L4 = plexus lumbalis
o L4-S2 = plexus sacralis
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Cervical enlargement
C5 - T1
Lumbar enlargement
L1 – S2
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Association
Projection
Commissural
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Exteroceptive (from surface): touch, vibration, pain, temperature, localization
Proprioceptive (deep, protopathic): locomotor system (periost, tendon and muscle spindles, joints); mostly nonconscious!
Interoceptive: from visceral system; mostly nonconscious! Base for proper function of the autonomic reflexes, homeostasis, neuroendocrine system
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Tractus spinothalamicus
Tractus spinocerebelaris
Fasciculus gracilis and cuneatus
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1. Direct pathway (pain, temperature, simple tactile sensations)
▪ Neospinothalamic tract
2. Indirect pathways (affective, autonomic, endocrine, motor, and arousal components of pain, and simple tactile sensations)
▪ Paleospinothalamic
▪ Spinoreticular
▪ Spinomesencephalic tracts 23
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Dorsal root ganglion
Dorsal root Dorsal horn (nucleus
proprius)
Lateral white column
Neuron I Neuron II
Tractus neospinothalamicus
Ventral posterolateral
nucleus of thalamus
Neuron III
Capsula interna Postcentral
gyrus (area 3,1,2)
Receptors in skin
Anterior white commissure
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Neurons located in the dorsal horn and intermediate gray matter
Ascend contralaterally and ipsilaterally Synapses in reticular formation Project in midline and intralaminar thalamic
nuclei – diffuse projections to the cortex and limbic regions (cingulate gyrus)
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Neurons located in the dorsal horn and intermediate gray matter
Ascend contralaterally and ipsilaterally Synapses in medullary and pontine reticular
formation Project in midline and intralaminar thalamic
nuclei – diffuse projections to the cerebral cortex
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Neurons located in the dorsal horn and intermediate gray matter
Ascend to the midbrain (PAG)
Descending projections to the spinal cord to inhibit pain sensations
Transmission to the amygdala via parabrachial nuclei?
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Neospinothalamic tract
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Neospinothalamic tract – anesthesia, thermoanesthesia, loss of simple tactile sensations
Sacral sparing – damage to the neospinothalamic tract leaves intact the pain, temperature, and simple tactile sensations in sacral dermatomes (lesion in the gray matter first affects thoracic and cervical fibers due to somatotopic organization of the tract)
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Tactile sense: vibration, deep touch, two-point discrimination
Kinesthetic sense: position and movement
Sacral and lumbar part = medial fasciculus gracilis (Goll’s fascicle)
Toracal and cervical part = lateral fasciculus cuneatus (Burdach’s fascicle)
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Dorsal root ganglion
Dorsal root Dorsal horn
Ipsilateral dorsal columns
Neuron I Neuron II
Fasciculus gracilis and
cuneatus
Nucl. gracilis and cuneatus
Neuron III
Postcentral gyrus (area
3,1,2)
Receptors in dermis;
proprioceptors
Medial lemniscus
Ventral posterolateral nucleus of thalamus
Capsula interna
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Dorsal (posterior) columns
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Tractus spinocerebellaris anterior – information about whole limb movement and postural adjustments (lower limb)
Tractus spinocerebellaris rostralis – upper limb
Tractus spinocerebellaris posterior – status of individual muscles and groups of muscles + tractus cuneocerebellaris
All enter cerebellum ipsilaterally!!! 33
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Dorsal root ganglion
Dorsal root Dorsal horn
Lateral funiculus
Neuron I Neuron II
Tractus spinocerebellaris
anterior
Superior cerebellar peduncle
Cerebellum (anterior lobe)
Receptors in tendons
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Dorsal root ganglion
Dorsal root Dorsal horn
Lateral funiculus
Neuron I Neuron II
Tractus spinocerebellaris
rostralis
Inferior cerebellar peduncle
Cerebellum (anterior lobe)
Receptors in tendons
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Dorsal root ganglion
Dorsal root Dorsal horn
(nucl. dorsalis of Clarke)
Lateral funiculus
Neuron I Neuron II
Tractus spinocerebellaris
posterior
Inferior cerebellar peduncle (restiform body)
Cerebellum (anterior lobe)
Receptors in joints, tendons
and muscles
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Nonconscious proprioception of upper limb
Rostral to C8 (no nucl. dors. of Clarke)
Ipsilaterally in the fasciculus cuneatus
Neuron II = accessory cuneate nucleus
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Tractus neospinothalamicus
Tractus spinocerebelaris
Fasciculus gracilis et cuneatus
Neuron I Dorsal root ganglion
Neuron II Dorsal horn
(nucleus proprius)
Dorsal horn (nucl. dorsalis
Clarke)
Nucl. gracilis et cuneatus
Neuron III thalamus thalamus
Function Pain and temperature Nonconscious proprioception
Discriminative touch and kinesthesia
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Corticospinal tract Rubrospinal tract
Tectospinal tract Vestibulospinal tract Reticulospinal tract
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Flexor motor system, fine movements of the limbs
Antigravity muscles, posture, and balance
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Homunculus – precentral gyrus Primary motor cortex
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Capsula interna
Crus cerebri
Pyramids
Anterior horn*
Neuron I
(upper
motoneuron) Tractus corticospinalis lateralis (90%)
Ventral root
Neuron II
(lower
motoneuron)
Spinal nerve
Precentral gyrus (area 4)
Tractus corticospinalis anterior (10%)
Corona radiata
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90% fibers cross at pyramidal decussation → lateral funicle (tractus corticospinalis lateralis): limb muscles
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10% fibers descend ipsilaterally (tractus corticospinalis anterior) and cross at the level of lower motoneuron: axial muscles
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Lower motor neuron paralysis:
•loss of voluntary movement,
•flaccid paralysis,
•loss of muscle tone,
•atrophy of muscles,
•loss of all reflexes
Upper motor neuron paralysis:
•loss of voluntary movement,
•spasticity,
•increased deep tendon reflexes,
•loss of superficial reflexes,
•Babinski sign
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monoplegia
hemiplegia
diplegia
paraplegia
quadriplegia (tetraplegia)
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Tractus corticospinalis
Neuron I (upper motoneuron)
Precentral gyrus (area 4)
Neuron II (lower motoneuron)
Spinal cord: anterior horn
*Plexus brachialis: C5-Th1
Plexus lumbosacralis: L1-S5
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Reflex arc – spinal segment:
Aferent neuron
Interneuron = Renshaw’s cell
Eferent neuron
Efector (muscle)
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Motor responses to afferent stimulation
Automatic reactions – fast response to pain and noxious
stimuli
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Triceps muscle stretch elicited by tapping the tendon causes agonists (triceps) to contract and antagonists
(biceps) to relax.
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Tractus rubrospinalis Tractus tectospinalis Tractus vestibulospinalis
(medialis and lateralis) Tractus reticulospinalis Fasciculus longitudinalis
medialis
Fasciculi proprii – intrinsic
reflex mechanisms of the spinal cord
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Nucleus ruber
Interneurons
Ventral horn
Ventral tegmental decussation
Inferior olive
Sensorimotor cortex
• Facilitation of flexor motor neurons
• Inhibition of extensor motor neurons
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Upper cervical segments
Colliculus superior
• Aid in directing head movements
in response to auditory and visual stimuli
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Interneurons Motor
neurons Extensor muscles
Vestibular apparatus
Nucl. vestibularis lateralis
Cerebellum
-
+
• Facilitation of ipsilateral extensor muscles
• Maintaining upright posture and balance
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• Adjustment of head position in response to
changes in posture (i.e. while walking)
Ventral horn Nucl. vestibularis
medialis
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Motor functions
Medullary (lateral) reticulospinal tract – supresses extensor spinal reflexes
Pontine (medial) reticulospinal tract – facilitates extensor spinal reflexes
Autonomic functions (ventrolateral medulla – IML of thoracolumbar cord)
Modulation of pain (enkephalinergic)
Midbrain PAG nucl. raphe magnus dorsal horn interneurons spinothalamic system
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MLF Ipsilateral upper cervical
motor neurons
Colliculus superior
Nucl. vestibularis medialis
Reticular formation
-
• Mainly ascending fibers!!!
• Head position control in response to excitation by the labyrinth
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Anterior median fissure
Anterior white commisure
Posterior median sulcus
Posterior intermediate sulcus
Tract of
Lissauer
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Segments of the spinal cord have a similar organization, but vary in appearance.
Always know where you are in the cord (i.e., cervical, thoracic, lumbar, sacral)
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Cervical cord is wide, flat, almost oval in appearance.
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Cervical
Cervical Enlargement
What’s different about the cervical enlargement?
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Less white matter than cervical
Rounder appearance Less prominent ventral
horns than cervical enlargement
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Less white matter than thoracic
Rounder appearance Larger ventral horns, especially
in lumbar enlargement
Lumbar
Lumbar Enlargement
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Not much white matter Mostly grey, although not much
of that either
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IML = T1-L2
Clarke’s nucleus = C8-L3
Fasciculus cuneatus = above T6
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Corticospinal tract Voluntary movement
Dorsal columns
Discriminative touch
Conscious proprioception
Spinocerebellar tract (dorsal and ventral)
Unconscious proprioception
Spinothalamic tract
Pain/temperature
Corticospinal tracts
Dorsal Columns
Spinothalamic tracts
Spinocerebellar tracts
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