ITN TrialShare: Promoting reproducible research and transparency in clinical trials Adam Asare, PhD...
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Transcript of ITN TrialShare: Promoting reproducible research and transparency in clinical trials Adam Asare, PhD...
ITN TrialShare: Promoting reproducible research and transparency in clinical trials
Adam Asare, PhDDirector, Data Analysis
12/11/2012
2
Reproducibility of results in published literature
Ionnidis, P. et al. Repeatability of published microarray gene expression analyses. Nat Gen , 41:2, Feb 2009
Immune Tolerance Network(ITN)
Clinical trials consortium whose mission is to accelerate the development of immune tolerance therapies
Therapeutic areas include: allergy/asthma, transplantation, and autoimmune diseases Over 50 Phase I/II clinical trials NIH/NIAID funded for over 12 years, ~30M/yearNumerous academic and industry partners
Core objectives: Innovation & CollaborationDevelop novel assay technologiesSupport rigorous and reproducible researchAdhere to standardized platforms and processesUse best practices approach to statistical methodology Disseminate data and results to research community
Web access to data and analyses: itntrialshare.org
Data analysis study archive
Manuscript figures and analysis code console
Download data and code baseRe-run analysis within system
Original Analysis
User-defined analysis figure and output
Data
Code
Create a new paradigm for research publishing Generate high-profile manuscripts that are interactive at the data and code level
Query for information regarding how the published data was generatedAllow exploration of alternative analysis approaches
Benefits realizedAllows rapid review of data and analysis approaches by study team internally for manuscript developmentPublic resource available to the research community for reference datasets and analysis approaches
Expect additional functionality to be phased in over time
Funding Attribution Slide: General ITN
National Institute of Diabetes & Digestive & Kidney Diseases
F U N D E D B Y :
National Institute of Allergy & Infectious Diseases
FoodAllergyInitiative