Isoprene Glycol One unique product for plenty of innovations

2016.11

Aroma chemicals

Cosmetic materials

Phermaceutical

intermediates

Solvents Chemicals

Products

Agrochemical

intermediates

・ Isoprene Glycol

・ Squalane

What is Isoprene Chemical Division?

Isoprene Glycol ( IPG )

Chemical name ： 3-methyl-1,3-butanediol

INCI name : Isopentyldiol

CAS Number : 2568-33-4

Production Site : Kashima Plant

Moisturizer

Solubilizer

Improve Feeling

Assist Preservative

Binder

Multi-function & Well-balanced material

Performances Features

Low odor

Safety

High purity

Unique Functions

Synergy effects

Production Site

Kashima Plant

Kashima plant

Tsukuba research laboratory

Okayama plant

Kurashiki research laboratory

Kurashiki plant

Saijo plant

Osaka head office Tokyo head office

Niigata plant

IPG was launched in 1991 in Japan.

It is produced at Kashima Plant.

Petroleum-derived Glycol.

Applications

Hair conditioner

Hair treatment

Make-up remover

Facial Wash

Hair styling

Lotion, Cream

Body wash

Sunscreen

Face mask

Widely introduced in Cosmetics and Toiletry products !

C5H12O2

IPG100％

203℃

116℃（COC）

< -50℃

250mPa・a

70.0mN/m (1g/L solution)

Physical Properties

Formula

Component

Boiling Point

Flash Point

Freezing Point

Viscosity

Surface Tension

:

:

:

:

:

:

:

Specifications

Appearance

Specific Gravity (20/20℃)

Refractive Index (20℃)

Purity (%)

Water (%)

Content (% Purity – Water)

Acid Value (KOH mg/g)

Ignition Residue (%)

Heavy Metal (ppm)

Arsenic (ppm)

：

：

：

：

：

：

：

：

：

：

colorless liquid

0.974～0.982

1.440～1.446

≧ 99.0

≦ 1.5

≧ 97.0

≦ 1.0

≦ 0.05

≦ 5

≦ 2

Regulatory Status

CRC-SEPA (China)

NDSL (Canada)

ECL (Korea)

ELINCS (EU)

REACH

ENCS (Japan)

PICCS (Philippine)

Swiss (Swiss)

CTFA (US)

ECN (Taiwan)

AICS (Australia)

: Listed

: Listed

: Listed (KE-23542)

: Listed (459-270-7)

: Registered

: Listed (2-240)

: Listed

: Listed (290800)

: Listed

: Listed

: Listed

Safety Data

Acute Toxicity (oral) ： LD50：5.00g/kg（mice）

Irritation (skin) ： Negative（Rabbits）

Irritation (eye) : Negative（Rabbits）

Repeat dose Irritation : Negative（Rabbits, 28days）

Skin sensitization : Negative（Guinea pigs）

Photo irritation : Negative（Guinea pigs）

Photo sensitization : Negative（Guinea pigs）

Genotoxicity : Non-mutagenic for S.typhimurium, E coil（Ames test）

Irritation (human skin) : Negative

Toxixity to fish : LC50：>103mg/l（Rainbow trout）

Safety and Eco-friendly

These data was obtained before the prohibition of animal test.

Repair Effect on Hair

Soaking hair in the solution(5%IPG+5%Sorbitol) for 30minutes.

Comparison photo of pre-treatment and post-treatment.（×700）

Before After

Repair Effect on Hair

＜Preparation＞

＜Procedure＞

1. Soak two bundles of hair in the three types of solution.

(3min, 10min each)

2. Rinse with tap water for 30 seconds, dry for 5 minutes.

3. Clip a bunch of hair to a height of 30cm.

4. Release the ring(6g) from above, record the fall distance.

5. Repeat five times on each to graph the average.

Record the fall distance

1. Soak two bundles of hair in 10% ammonia solution for 30 minutes.

2. Soak for 15 minutes in tap water.

3. Rinsed with tap water flow for 30 seconds.

4. Wipe off the moisture with a towel and dry with the dryer for 5 minutes.

3 types of solution are used:

①5%IPG+5%Sorbitol ②10%IPG ③10%Sorbitol

(Image)

~RING SLIDING TEST~

0

2

4

6

8

10

12

14

16

No damage

No treatment 3min Damaged

No treatment 10min

5%IPG＋

5%Sorbitol

10%Sorbitol

10min

10%IPG

3min 10min 3min

~RING SLIDING TEST~ Sliding

Distance

(cm)

＜Result＞

The solution(5%IPG+5%Sorbitol, soaked 10minutes) resulted in the best.

⇒IPG can be effective to repair damaged hair in combination with Sorbitol.

Irfaq: 10 E 2771-A

Repair Effect on Hair

Silkier

Damaged

No treatment

5%IPG＋

5%Sorbitol

~RING SLIDING TEST (Comparison with other glycols)~ Sliding

Distance

(cm)

Irfaq: 10 E 2626

Repair Effect on Hair

Silkier

0

1

2

3

4

5

6

7

5%DPG＋

5%Sorbitol

5%1,3-BG＋

5%Sorbitol

5%PG＋

5%Sorbitol

Moisturizing Effect

＜Measurement Timing＞

＜Cream＞

“Basic Cream” without moisturizer

“Basic Cream” + IPG 5%

“Basic Cream” + IPG 5% + Sorbitol 5%

“Basic Cream” + Hyaluronate sodium 0.5%

＜Procedure＞

1. Wash 10 application spots with lauryl sulfate sodium solution

and dry.

2. Measure amount of moisture before application.

3. Using every peace of cream 0.1g each. Applied to the same spots.

4. Measure amount of moisture at each timing below.

① Before application ② 5m later ③ 1h later ④ 2h later

~Water Measurement by Corneometer （5 panelists）~

Moisturizing Effect

Ratio of Water Increase in Comparison with before Application

Combination with sorbitol can increase moisturizing effect.

Positive

effect

No effect After 5 min. After 1 Hour After 2 Hours

Ra

tio

of

Wa

ter

Inc

rea

se

(%)

IPG + Sorb.

IPG

IPG

Cleansing Performance

~Sensory Assessments of Cleansing Performance of Glycols by 4 Volunteers~

＜Procedure＞

１. Wash face with a 25% lauryl sulfate sodium solution.

２. Rinse with tap water.

３. Dry with terry towel.

４. Wait for 15 minutes to rebalance skin.

５. Apply liquid foundation and lipstick evenly on each side.

６. Wait for 10 minutes to let make-up dry.

７. Apply 1.0±0.1g test solution on make-up remover pads.（4types）

８. Use pads 10times each to remove, foundation and lipstick respectively.

① IPG ②Monopropylene Glycol ③Butylene Glycol ④Dipropylene Glycol

＜Before＞

Prepare 4 types of glycols 10% water solution

10% Isoprene Glycol

10% Monopropylene

Glycol

10% Butylene Glycol

10% Dipropylene

Glycol

Performance as make-up remover

Foundation 5 5 3 5

Lipstick 8 6 7 7

Skin freshness 7 5 6 5

Absence of stickiness 8 8 6 7

Skin softness after make-up removal 8 8 7 7

Irfaq : 10/ E 2770-A

bad←１～８→good

Cleansing Performance

Sensory Assessment by 4 Volunteers

IPG can stabilize in O/W emulsion

Dispersion Performance in O/W Emulsion

When used 5% in the water phase, oil droplets are finer

compared to the same formula without IPG.

＜with IPG＞ ＜without IPG＞

(anti ageing cream) O/W emulsion

Solubility Data

IPG 1,3-BG PGWater >100 >100 >100

Ethanol >100 >100 >100Cetanol >100 >100 >100

Stearic acid >100 >100 >100Olive oil 0.4 0 0

Glycerin monostearate >100 >100 >100Glycerin tristearate 2 0 0

Cetyl ethylhexanoate 2.7 1 0.6Trimethylstearylammonium

chloride>100 >100 >100

POE(20) sorbitan mono stearate >100 69 >100Sodium POE lauryl ether sulfate >100 >100 >100

Sodium lauryl sulfate >100 65.4 >100Liquid paraffine 1.2 0 0

Squalane 0.8 0 0

SolubitilitySolute

Solubility Data ( IPG, 1,3-BG, PG )

（％）

IPG can be useful to solubilize difficult actives.

＋・・・Good growth

±・・・Growth

－・・・No growth

Bacteriostatic

Comparison of Bacteriostatic (IPG, BG,DPG, PG)

Ensured that the bacteria were not killed.

Content Rate of IPG

Hair conditioner ・・・・・ 4~6%

Hair treatment ・・・・・ 5~7%

Make-up remover ・・・・・ 4~10%

Facial wash ・・・・・ 4~11%

Body wash ・・・・・ 1~5%

Hair wax ・・・・・ 2~11%

Cream ・・・・・ 1~3%

Hand wash ・・・・・ approx.10%

＜Example＞