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IsoniazidBy Philisile, Chemistry Research.

Isoniazid is also known as Nydrazid, 4-pyridinecarboxylic acid, and isonicotinylhydrazine (INH),

C6H7N3O.

Taken from Zentiva products,http://www.zentiva.cz/default.aspx/en/productwide?Kod=03303&DetailType=detail&Type=10

Major Functions:

Isoniazid is used to treat tuberculosis and prevent disease development in people who have had anexposure to mycobacterium tuberculosis. It is used as a preventative therapy for People who are infectedwith HIV, and people who have been reported to have medical conditions that increase the risks of

tuberculosis like diabetes mellitus, silicosis and leukemia.

www.nandlalbankatlal.com/other-images/10010-1.jpg

Chemical mechanism or interaction:

Isoniazid (INH) is activated by the heme enzyme catalase peroxidase (KatG) which is found within themycobacterium tuberculosis.

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http://en.wikipedia.org/wiki/Carbonhttp://en.wikipedia.org/wiki/Hydrogenhttp://en.wikipedia.org/wiki/Hydrogenhttp://en.wikipedia.org/wiki/Nitrogenhttp://en.wikipedia.org/wiki/Oxygenhttp://en.wikipedia.org/wiki/Hydrogenhttp://en.wikipedia.org/wiki/Nitrogenhttp://en.wikipedia.org/wiki/Oxygenhttp://en.wikipedia.org/wiki/Carbon

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1. Drugs.com. http://www.drugs.com/pro/isoniazid-tablets.html (accessed Nov, 25,2009).

2. IPCSINCHEM: Isoniazid (PIM 288)http://www.inchem.org/documents/pims/pharm/pim288.htm(accessed Nov, 23, 2009).

3. MedicineNet.com: Drug Induced Liver Diseasehttp://www.medicinenet.com/drug_induced_liver_disease/page8.htm (accessed Nov,25, 2009).

4. Richard V. Wolfenden (2003). Adduct affinity and drug resistance,http://www.pnas.org/content/100/24/13881.full(accessed Nov 23, 2009).

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http://www.drugs.com/pro/isoniazid-tablets.htmlhttp://www.inchem.org/documents/pims/pharm/pim288.htmhttp://www.medicinenet.com/drug_induced_liver_disease/page8.htmhttp://www.pnas.org/content/100/24/13881.fullhttp://www.drugs.com/pro/isoniazid-tablets.htmlhttp://www.inchem.org/documents/pims/pharm/pim288.htmhttp://www.medicinenet.com/drug_induced_liver_disease/page8.htmhttp://www.pnas.org/content/100/24/13881.full