Iselets of Langerhans
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B A D F Islets of Langerhans > Clusters of Rounded Endocrine cells amougst the Exocine Pancreas > 1-2% of total volume of pancrease, 500K/pancreas Function 1) Regulate Serum Glucose > Insulin: lowers blood sugar > Glucagon: raises blood sugar 2) Somatostatin 3) VIP 4) 5HT 6) Amylin 7) Pancreatic Polypeptide Cell Types in the Islets of Langerhans Alpha: 15-20% Glucagon @ Outer Mantle Beta: 70% Insulin @ Inner Core Delta <5% Somatostatin @ Outer Mantle F-cell rare Pancreatic PPT Blood Supply is "Core-to-Mantle" and carries "Secretogogues" (like glucose) from Inside to Outside "Insulo-Acinar Portal System" >>> Portal Vein >>> Liver > Glucagon >>> Insulin > Insulin >>> Insuline (Autocrine) > Insulin ---x Glucagon > Somatostatin ---x (Insulin + Glucagon) SS~R~Exocrine Cells ---x HCO3 + Digestive Enzymes Cell Morphology > made for regulated secretion of peptide hormones > Large RER, prominentn Golgi, Storage Granules (Dense-Core Secretory vesicles with HALOs) glycoprotein Innervation: Sympathetic + Parasympathetic, 10% of cells are Synapsed Upon > Gap Junctions between B-Cells Islets of Langerhans D B A Insulin Somatostatin Glucagon To Portal Vein Blood Flow Insulin Glucagon Somatostatin
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Transcript of Iselets of Langerhans
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BA
DF
Islets of Langerhans > Clusters of Rounded Endocrine cells amougst the Exocine Pancreas > 1-2% of total volume of pancrease, 500K/pancreas
Function 1) Regulate Serum Glucose > Insulin: lowers blood sugar > Glucagon: raises blood sugar 2) Somatostatin 3) VIP 4) 5HT 6) Amylin 7) Pancreatic Polypeptide
Cell Types in the Islets of Langerhans Alpha: 15-20% Glucagon @ Outer Mantle Beta: 70% Insulin @ Inner Core Delta >> Portal Vein >>> Liver > Glucagon >>> Insulin > Insulin >>> Insuline (Autocrine) > Insulin ---x Glucagon > Somatostatin ---x (Insulin + Glucagon) SS~R~Exocrine Cells ---x HCO3 + Digestive EnzymesCell Morphology
> made for regulated secretion of peptide hormones > Large RER, prominentn Golgi, Storage Granules (Dense-Core Secretory vesicles with HALOs) glycoprotein
Innervation: Sympathetic + Parasympathetic, 10% of cells are Synapsed Upon > Gap Junctions between B-Cells
Islets of Langerhans
D
B
A
Insulin
Somatostatin
Gluc
agon
To Portal Vein
Bloo
d Fl
ow
Insu
lin
GlucagonSom
atostatin
