Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be...
Transcript of Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be...
![Page 1: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/1.jpg)
Is there gene*c resistance of Nellore ca2le to both *cks and gastro-intes*nal parasites?
FabioLuizBuraneloToralDepartmentofAnimalScience/UFMG
AndreaWilson’sgroup
GeneAcsandGenomicsDivision/Roslin
13thMeeAngEdinburghAllianceforComplexTraitGeneAcs
RoyalSocietyofEdinburgh
![Page 2: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/2.jpg)
Brazilian ca2le
• 210-220Mheads
• ~80%beefcaQle• 168–176Mheads
• ~70%Zebubreeds• ~75%Nelloreorcrossbred
• 88–92MNelloreorcrossbred
![Page 3: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/3.jpg)
Nellore is widely distributed over Brazil
PonteseLacerda,MT CarlosChagas,MG
![Page 4: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/4.jpg)
Nellore is exposed to great seasonal varia*on
NeloreLemgruber NeloreIRCA
![Page 5: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/5.jpg)
Animals should stay healthy along the year
Toreproduce Togrowth
ABSPecplanDanielResende
![Page 6: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/6.jpg)
To achieve sustainability in livestock produc*on • Animalbreeding• Sanity• NutriAon• Animalwelfare• Etc…
![Page 7: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/7.jpg)
The annual cost with an*parasi*c for ruminants in Brazil – 2016
R$852.5M £198.2M
AdaptedfromSINDAN(2017).
![Page 8: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/8.jpg)
Animal breeding is about to explore differences between and within breeds
Selec:onCrossbreeding
![Page 9: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/9.jpg)
Significant difference between gene*c groups for *ck counts
AdaptedfromIbellietal.(2012).
![Page 10: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/10.jpg)
Non significant difference between gene*c groups for number of eggs per gram
Oliveiraetal.(2013).
![Page 11: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/11.jpg)
Non significant effect of gastrointes*nal nematodes on Nellore growth Meannumberofnematodesintheresistant(n=10)andsuscep:ble(n=10)groupsofNelloreyoungbullsnaturallyinfectedbygastrointes:nalnematodes
Bodyweightoftheresistant(n=10)andsuscep:ble(n=10)groupsofNelloreyoungbulls,naturallyinfectedwithgastrointes:nalnematodes
Nematodes Resistant Suscep:ble Significance
Haemonchusspp. 156 1,272 <0.01
Cooperiaspp. 1,500 4,807 <0.05
Oesophagostomumspp. 100 174
Trichurisspp. 22 22
Total 1,778 6,275 <0.05
AdaptedfromBricarelloetal.(2007).
![Page 12: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/12.jpg)
Non significant effect of *ck and gastrointes*nal nematodes on Nellore growth Group N Mean(g/day) SE(g/day)
Tick
High 533 557.37 3.24
Low 568 552.17 3.12
Nematodes
High 520 553.28 3.32
Low 581 555.84 3.12
Barbosa(2016).
![Page 13: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/13.jpg)
Do *cks and nematodes affect Nellore performance?
• Yes.So,whytheresearchersdidn’tfindthis?
• No.So,whythefarmersspendsomuchmoneyonparasitetreatments?
![Page 14: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/14.jpg)
Increase food safety in beef
• GeneAcvariaAonforresistancetoparasites(Acks,nematodesandEimeriaspp.)
• SelecAonasacomplementarytoolinparasitecontrolprograms
• ReducetheuAlizaAonofchemicalsinbeefcaQleproducAonsystems
![Page 15: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/15.jpg)
Data recording in a Nellore seedstock farm
• Youngbullsonpastureperformancetests(294d)• Groupsof30-35animals(8groups/year)• 70dofadaptaAon• EvaluaAons(weightandparasitecounts)every56d,unAl550daysofage• Upto5measurements/animal
• FromApril2011toMay2017• 7,871Ackcounts(1,713animals,130sires)• 7,292nematodesandEimeriaspp.counts(1,712animals,130sires)• 5,920animalsinthepedigree
![Page 16: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/16.jpg)
Distribu*ons of parasite counts are neither Gaussian nor Poisson
![Page 17: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/17.jpg)
FiPng of Zero Inflated Poisson distribu*ons
• Tickcountindairycows(Silvaetal.,2011)
• Tickcountinsheep(Sae-Limetal.,2017)
• Faecaleggcountinsheep(Wangetal.,2017)
• NumberofmasAAscasesindairycows(Rodriges-MoQaetal.,2007)
![Page 18: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/18.jpg)
FiPng of ZIP distribu*ons
![Page 19: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/19.jpg)
The interpreta*ons of gene*c parameters are not trivial under ZIP models • ThereisnoobviouslyusefuldefiniAonofheritability(Rodrigues-MoQaetal.,2007).
• WeassessedtheimportanceofaddiAvegeneAcdifferencesbetweenanimalsfijngmodelswithoutandwithaddiAvegeneAceffect.
• WeassessedtherelaAonshipbetweenphenotypesandbreedingvalues(underliabilityscale).
![Page 20: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/20.jpg)
Low phenotypic correla*on between parasite counts
0.11(0.09,0.13)
0.04(0.02,0.06)
0.14(0.11,0.16)
![Page 21: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/21.jpg)
Gene*c varia*on was found to be important
Addi:vegene:ceffectParasite Without WithTick 42,532 42,515Nematodes 38,545 38,527Eimeriaspp. 33,366 33,359
DevianceinformaAoncriterionaccordingtostaAsAcalmodels
![Page 22: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/22.jpg)
Gene*c varia*on was found to be important
Tick Nematode Eimeriaspp.Effect Mean Median S.D. Mean Median S.D. Mean Median S.D.
Animal(A) 0.140 0.137 0.023 0.289 0.289 0.012 0.187 0.176 0.047Permanentenvironment(Pe)
0.211 0.209 0.018 0.238 0.238 0.009 0.600 0.596 0.046
Group(Gr) 1.037 1.030 0.085 0.416 0.412 0.038 4.658 4.615 0.046
A/(A+Pe+Gr) 0.101 0.306 0.034(A+Pe)/(A+Pe+Gr) 0.253 0.559 0.145
![Page 23: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/23.jpg)
Correla*ons between breeding values are low to moderate
0.30(0.27,0.32)
0.01(-0.02,0.03)
-0.07(-0.09,-0.04)
![Page 24: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/24.jpg)
Moderate rela*onships between breeding values and phenotypes
0.59(0.56,0.62)
0.77(0.75,0.79)
0.41(0.37,0.45)
Tick Nematode Eimeriaspp.
![Page 25: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/25.jpg)
Animals with the best breeding values have smaller parasite counts
![Page 26: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/26.jpg)
Animals with the best breeding values have smaller parasite counts
![Page 27: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/27.jpg)
Animals with the best breeding values have smaller parasite counts
![Page 28: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/28.jpg)
Conclusions
• ThereisgeneAcresistanceofNellorecaQletobothAcksandgastro-intesAnalparasitesAcks.
• TickandnematodescountsmaybegeneAcallycorrelated.
• BreedingvaluesunderliabilityscalesareusefulforselecAonofresistantanimals.
![Page 29: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/29.jpg)
Next steps
• GWASforresistancetoAcksandgastro-intesAnalparasites.
• TofitmodelsaccounAngforinfecAvity.
• IstheregeneAccorrelaAonbetweenresistanceandinfecAvity?
![Page 30: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/30.jpg)
Acknowledge
• UFMG• CNPq• FAPEMIG• CAPES• MundoNovoRanch
• RonaldoLeite• EduardoCardoso• DanielGoncalves• AndreaWilson• OsvaldoAnacleto
![Page 31: Is there genec resistance of Nellore cale to both cks and ... · Gene*c varia*on was found to be important Tick Nematode Eimeria spp. Effect Mean Median S.D. Mean Median S.D. Mean](https://reader035.fdocuments.in/reader035/viewer/2022081611/5f038ca27e708231d4099a36/html5/thumbnails/31.jpg)
Acknowledge
• JuanPabloBoteroCarrera• TiagoLucianoPassafaro• LiviaLoioladosSantos• DalinnedosSantos• FernandaRaidan• MullerGomes• GlausenLima
• AdrianeBarbosa• LarissaKretli• MarianaMamedes• AndresaMelo• GabrielaGouveia• VirgíniaRibeiro• LuizaAbreu• Etc…Thankyou!