Chapter 6. Physics is the branch of science that deals with the interactions of matter and energy.
is the branch of learning that deals with how the organism ...
Transcript of is the branch of learning that deals with how the organism ...
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is the branch of learning that deals with how the organism reacts to the presence of micro- and nano-particles
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PM10Nanoparticle
Red cells
Scale of dimensions of biological and synthetic materials
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5 micron
Examples of environmental pollution from a foundry
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6ControlV2LeukemiaIV6Neu-LexovaIII10AnomaliesII
7Anencephalic birthI
No. CasesPathologies
Analyzed samples:
liver, kidney, lung, bladder, gonads, brain, placenta
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Control samplesLiver
Lung
Heart
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Placenta
PC
O
Ca
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Brain
C
Cr
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Acute Mieloid Leukemia from Mantua(n. int. 478 MN - 481 MN)
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Kidney
C,P,O,CaZn,S,Cl,FeDebris13
C,O,Si,Cl,Ca,S,Na,P,Al,K,Fe,MgCluster of Debris12
C,P,O,Ca,Na,Cl,S,Fe,ZnCluster of Debris11
C,Bi,O,Na,P,Si,NDebris 0,5 µm10
C,Fe,O,Cl,Cr,S,Si,Ca,Na,MgCluster of debris9
C,Fe,O,Cl,Cr,S,Si,Ca,Na,MgDebris 0,2 µm8
C,Cr,O,Cl,SDebris 2 µm7
C,O,Si,Cl,Ca,S,Na,P,Al,K,Fe,MgDebris 7 µm6
C,Si,O,Na,Ca,K,Cl,P,N,sDebris 5 µm5
C,O,Fe,Na,P,S,Cl,NDebris 2 µm4
C,O,Cl,Fe,S,Na,P,NDebris 2 µm3
C,O,Cl,Fe,S,P,Cr,Na,NDebris 2 µm2
C,O,Cl,Na,S,P,NBiological tissue1
Chemical elementsMorphologyN°
Analysis
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Kidney
Stainless steel nanoparticles
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Kidney
Bismuth particle
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Limph-node
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C,Zn,P,S,Cl,Ca7 µm debris5
C,Fe,Si,O,Cl,Mn,Zn,Cu,S,Al,Ca0,1 - 2 µm spherules 4
Si,C,O,Na,Cl,Al,Ca,K,Mg,Fe1 - 4 µm debris3
C,Ni,O,Cl,Si,Ca,NaCluster of 2 µm spherules2
C,O,Cl,Na,S,PBiological tissue1
ElementsMorphologyN°
Analisi
Heart
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HeartDebris of Iron-
Manganese-Copper-Zinc
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HeartCluster of
nanoparticles of Nickel
compound
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Brain with Titanium
nanoparticles
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Spleen of a spina byphida caseCT 485 A
C,P,O,Fe,Na,Ca,S,Mg100 µm clusters
9
C,Ca,O,Si,Ti,Al,P,S,Cl,NaK,Fe,Mg5 µmclusters8
C,O,Ba,S,Ca,Si,Al,Na,Fe10 µm clusters7
C,O,Fe,Si,Al,Na,S2 µm debris6
C,O,P,Fe,Zn,Ca,S,N0,5 - 2 µm clusters5
Si,C,O,P,P,Na,S,N7 µm debris4
C,O,P,Fe,Na,Ca,Mg,Sclusters3
C,Si,O,Al,Na,Ca,P,S,N5 µm debris2
C,O,S,P,Na,NBiological tissue1
ElementsMorphologyAnalysis
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Spleen
Iron-Phosphorus-Zinc PrecipitatesPFeZn
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Kidney
Iron-Phosphorus Precipitates
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Liver
Fe
Cu Zn
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Spina Byphida KidneyB 46/06 CT 487 B
487 CT
Laboratorio dei Biomateriali- Dott. Gatti
800-nm toxic particle of Lead
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Spina byphida
Liver A 251/06
Laboratorio dei Biomateriali- Dott. Gatti
488 CT
Stainless steel Nanoparticle
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Spina byphida Liver
B 251/06 488 B
Bismuth Nanocristals
Laboratorio dei Biomateriali- Dott. Gatti
488 CT
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Laboratorio dei Biomateriali- Dott. Gatti
489 CT
Spleen
B 925/06CT 489 B
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Spleen
Chromium-Iron Debris
Cr
Fe
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20-week Foetus of uncertain sex
MORRIS SYNDROME
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Ca,P,C,O,S,Zn,Fecalcification4
C,O,S,Ba3 µm debris3
Ca,P,C,O,S,Zn,Fecalcification2
C,O,S,Naplacenta1
ElementsMorphologyAnalysis
Placenta (MN 498 A)
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PLACENTA
MN 498 A)
S Ba
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C,Ca,O1 -10 µm debris4
C,S,Fe,O,Si0,2 µm-4 µm cluster3
C,Fe,O,Na3 µm debris2
C,O,S,Na,PTissue1
ElementsMorphologyAnalysis
Brain (MN 498 B)
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Brain
S
Fe
Nanoparticles of Sulphur-Iron from a refinery pollution
(MN 498 B)
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Lung (MN 498 C)
Zn,Al,C,Ocluster6
C,O,Bi,Na,P,S0,5 µm debris5
Fe,C,O,Si,P,S,Ti,Mnnanoparticles4
C,Fe,O,Cr,Ni,Si,P,S,Na 2 µm debris3
Fe,C,O,Si,P,S,Ti,Mn0,2 µm-10 µm cluster2
C,O,P,S,Natissue1
ElementsMorphologyAnalysis
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Lung
Nanoparticles of Iron
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Bi
Fe
Cr Ni
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21-week male Foetus Spontaneous Delivery with corionamnionite.
Found particles ofZinc,
Lead-Calcium-Bromide,Cerium-Phosphorus,
Gold-SulphurSilver-Sulphur
Tinin placenta, liver and lung
MN 499
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Heart
Ag
S
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Liver
Zn
Cr
Fe
Ni
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Kidney
Zn
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19-week male foetus with16-CROMOSOMIC TRISOMIA
Found particles and precipitates of Aluminium
Titanium-Antimony,
MN 500
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C,Zr,Si,O,Na,Fe1-5 µm debris
7
O,Al,C,Parea with
Alluminium6
O,Cr,C,S0,1 -5 µmdebris5
C,P,Ca,Fe,Na,S,Znprecipitates4
Ti,C,O,Sb,Cr,P,Na5 µm debris
3
C,Fe,O,P,Si,Na2 µm debris2
C,O,S,Naplacenta1
ElementsMorphologyAnalysis
Placenta (MN 500 A)
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Al
P
PLACENTA is full of ALLUMINIUM
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Lung
Al
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Heart(MN 501 D
La Ce Nd Fe
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Neu-Laxova syndrome is a rare congenital abnormality characterised by intrauterine growth restriction, microcephaly, facial dysmorphy, short
neck, edema, scaly skin and perinatal death. Additional features such as spina biphida,
cryptorchidism and shallow orbital cavities have been reported. Chromosomal analysis in reported
cases has revealed a normal karyotype and an autosomal recessive inheritance has been
postulated.
Neu-Laxova syndrome
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The 6 cases of Neu-Lexova occurred within 20 months
present similar contamination
• Particles of Antimony• Tin and Stainless steel• Bismuth-Chlorine• Strontium-Sodium• Lead-Bismuth and Zinc
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111 MA - Liver
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111 MA - Liver
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111 MA - Liver
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111 MA - Liver
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111 MA
Kidney
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156 MA
Liver
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156 MA
Liver
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Impact of the environmental nanopollution
Disease
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Associazione CarloBortolani Onlus
The study was supported by
The group of Nanopathology
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The ability to think differently today from yesterday distinguishes the wise man from the stubborn.
J.Steinbeck (Nober Prize 1962)