INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone...
Transcript of INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone...
![Page 1: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/1.jpg)
INTRODUCTION TO LLS THERAPY ACCELERATION PROGRAMOctober 2019
![Page 2: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/2.jpg)
PAGE
BLOOD CANCERS
Every 3 minutes someone in the US is diagnosed with a blood cancer.
More than one third of blood cancer patients do not survive five years after diagnosis.
Despite improved outcomes, we need to do more!
![Page 3: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/3.jpg)
PAGE
OUR MISSION
Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality of life of patients and their families
More than $1.3 billion invested in research
Advocacy to accelerate cures and access
Unparalleled patient support and education
services
![Page 4: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/4.jpg)
PAGELLS Research focuses on discovering and developing therapies to positively impact care for blood cancer patients
Discovery Development Commercialize
Patient Education, Access & Advocacy
Research Grant Programs
TherapyAcceleration
Program®
Beat AML Initiative
![Page 5: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/5.jpg)
PAGE
Research by Funding Mechanism - FY18
TRP 32%
$52.6 Million
Canada 7%
MCL 4%
CDP 20%
TAP 12%
SCOR 18%
Other 5%
![Page 6: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/6.jpg)
PAGETherapy Acceleration Program (TAP)
Strategic initiative established in 2007
Accelerate high-risk innovative blood cancer therapeutics
Meeting LLS Mission is first priority
Generating ROI to further fund LLS Mission is secondary
Biotechnology Accelerator Academic Concierge Co-funding up to 50% Funding up to 100%
LLS TAP
![Page 7: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/7.jpg)
PAGE
Venture Philanthropy since 2007
$120M+ investment 60+ projects 18 in current portfolio
3 FDA Approvals Vyxeos (AML) Yescarta (DLBCL, tFL, PMBCL) Elzonris (BPDCN)
LTherapy Acceleration Program (TAP) Supports Emerging New Therapies
www.lls.org/therapy-acceleration-program
![Page 8: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/8.jpg)
PAGEDevelopment Stages of TAP Portfolio
Current Total
Development Phase
Phase II Reg / Phase III 3 7
Phase II (Non Registration) 7 11
Phase I 5 23
Preclinical 2 19
Clinical Trial Networks/ Patient Care
1 4
TOTAL 18 64
Current Focus:Clinical Proof of Concept
![Page 9: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/9.jpg)
PAGESelect Projects in Current TAP Portfolio
![Page 10: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/10.jpg)
PAGELLS TAP Process
Open to funding application year round All hematological indications Focuses on therapeutics development in the clinic Typically $2-6M dollars (co-funding for companies)
– equity or milestone based Applicants fill out 1-page Inquiry Form to start the process
LLS Staff Evaluation
External Expert
Consultation
TAP Committee
Review
Contract Negotiation &
Execution
Project Management
How to apply for TAP: www.lls.org/therapy-acceleration-program
![Page 11: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/11.jpg)
PAGE
LLS TAP Funding Is Competitive
Average annual number; typically 3-6 month to reach TAP Committee Review
October 2019
![Page 12: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/12.jpg)
PAGELLS TAP Committee
Subcommittee of LLS National Board Members consist of KOLs, IP lawyer, VC-investors in
biotech, Industry veterans
TAP Research performs S&E and recommends TAP projects to the Committee
Company presents to the TAP Committee
The Committee may approve, conditionally approve or reject company funding request
Committee approval provides Research BD to proceed to Term Sheet and then formal Agreement
![Page 13: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/13.jpg)
PAGEKey Criteria
High Unmet Medical Need Innovative Science
First-in-Class
High potential to impact clinical practice
Clinical PoC Study or Registration-Directed Study
Strong IP Position
Competent Management Team
Solid Corporate Finance
![Page 14: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/14.jpg)
PAGE
Why Companies Come to TAPin addition to $$
Deep knowledge of blood cancer landscape
Expertise in hem/onc clinical development within LLS and via KOLs
Connections to patients Advocacy efforts for patients Biotech companies leverage LLS approval to raise
additional funds Track record of success
![Page 15: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/15.jpg)
PAGETAP is Bridging the Gap for Biotech
![Page 16: INTRODUCTION TO LLS HERAPY CCELERATION ROGRAM TAP... · BLOOD CANCERS PAGE Every 3 minutes someone in the US is diagnosed with a blood cancer. More than one third of blood cancer](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed8b2e56714ca7f47686820/html5/thumbnails/16.jpg)
We have one goal: A world without blood cancers
THANK YOU