11-111 The Work of Gregor Mendel -1 The Work of Gregor Mendel
Introduction to Genetics Chapter 11. 11- 1 The Work of Gregor Mendel Every living thing – plant or...
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Transcript of Introduction to Genetics Chapter 11. 11- 1 The Work of Gregor Mendel Every living thing – plant or...
![Page 1: Introduction to Genetics Chapter 11. 11- 1 The Work of Gregor Mendel Every living thing – plant or animal, microbe or human being – has a set of characteristics.](https://reader036.fdocuments.in/reader036/viewer/2022062313/56649cda5503460f949a42e0/html5/thumbnails/1.jpg)
Introduction to Genetics
Chapter 11
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11- 1 The Work of Gregor Mendel
• Every living thing – plant or animal, microbe or human being – has a set of characteristics inherited from its parents
• Since the beginning of recorded history, people have wanted to understand how that inheritance is passed from generation to generation
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Genetics• The scientific study of heredity
• Heredity- the passing on of characteristics from parents to offspring
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Other important Vocabulary words:
• Heredity *dominant• Trait *recessive• Gamete *law of segregation• Fertilization *phenotype• Zygote *genotype• Pollination *homozygous• Hybrid *heterozygous• Allele *law of independent assortment
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Gregor Mendel• Austrian Monk• Born 1822 in Czech
Republic• Worked at monastery and
taught high school• Tended the monastery
garden in Austria• Grew peas and became
interested in the traits that were expressed in different generations of peas
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Why the pea plant?
• Reproduce sexually (use gametes)
• Easy to cross pollinate ensuring control of the parental generation
• Easy to study one trait at a time
• Very distinguishable traits
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• Mendel was the first person to succeed in predicting how traits are transferred from one generation to the next.
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True breeding• If allowed to self pollinate they
would produce offspring identical to themselves
• He was also able to cross breed peas for different traits
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Genes and Dominance• Mendel studied seven different
pea plant traits
• Each trait he studied had a contrasting form
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Pea Plant Traits
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Genes and Dominance• The offspring of crosses between
parents with different traits are called Hybrids
• When Mendel crossed plants with different traits he expected them to blend, but that’s not what happened at all.
• All of the offspring had the character of only one of the parents
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Mendel’s generations
• Parents: (P) trait of height. Tall x Short
• First generation: (F1) All tall
• Second generation: (F2) allowed first generation tall plants to self pollinate. ¾ were tall and ¼ were short
• * “F” stands for filial- son or daughter
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Mendel drew two conclusions
1. “Rule of Unit Factors”
Inheritance is determined by factors that are passed from generation to generation – today we call these factors genes
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Alleles• Different forms of a gene
• Examples: Gene of plant height: alleles for tallness, alleles for shortness
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Mendel’s 2nd conclusion
2. The Rule of Dominance
• Some alleles are dominant and some are recessive
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dominant• Covers up the recessive form
Ex.) T = tall
• “observed trait of an organism that masks the recessive form of a trait”
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recessive• Gets covered up in the presence
of a dominant allele
Ex.) t = short
• “trait of an organism that can be masked by the dominant form of a trait”
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Expression of Alleles
• Upper case letter represent dominant alleles and lower case letters represent recessive alleles.
• Examples: for plant height
• T= tall t=short
• TT= tall
• tt= short
• Tt= tall
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Law of Segregation• Mendel wanted to answer another
question
Q: Had the recessive alleles disappeared? Or where they still present in the F1 plants?
• To answer this he allowed the F1 plants to produce an F2 generation by self pollination
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P1 Parental
Tall Short All Tall
F1 F2
3 tall : 1 short
75% tall
25% short
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The F1 Cross• The recessive traits reappeared!
• Roughly 1/4 of the F2 plants showed a recessive trait
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Explanation of the F1 Cross• The reappearance indicated that at some point
the allele for shortness had been separated from the allele for tallness
• Mendel suggested that the alleles for tallness and shortness in the F1 plants were segregated from each other during the formation of sex cells or gametes
• When each F1 plant flowers, the two alleles segregate from each other so that each gamete carries only a single copy of each gene. Therefore, each F1 plant produces two types of gametes – those with the allele for tallness and those with the allele for shortness
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30 minute video
• http://www.youtube.com/watch?v=6OPJnO9W_rQ
• Watch this at home if you need more help
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Probability and Punnett Squares
• Mendel kept obtaining similar results, he soon realized that the principals of probability could be used to explain the results of genetic crosses
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Probability• The likelihood that a particular
event will occur
• The way in which alleles segregate is random like a coin flip
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Punnett Square Vocab
• Phenotype
• Genotype
• Homozygous
• heterozygous
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Punnett Square• Diagram used to determine
genetic crosses
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Homozygous• Organisms that have 2 identicle
alleles for a trait
Ex.) TT , tt
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Heterozygous• Have two different alleles for a
trait
Ex.) Tt
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Phenotype• Physical characteristics – (words)
Ex.) tall
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Genotype• Genetic make-up - (letters)
Ex.) Tt, TT, tt
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Bozeman biology video
• http://www.youtube.com/watch?v=NWqgZUnJdAY&feature=related
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11-3 Exploring Mendelian Genetics
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• Mendel wondered if alleles segregate during the formation of gametes independently
• Does the segregation of one pair of alleles affect the segregation of another pair of alleles?
• For example, does the gene that determines whether round or wrinkled in shape have anything to do with the gene for color?
• Must a round seed also be yellow?
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All heterozygous 9:3:3:1 Ratio
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Independent Assortment• Genes that segregate
independently do not influence each others inheritance
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A Summary of Mendel’s Principles
• The inheritance of biological characteristics is determined by individual units known as _______________. In organisms that reproduce sexually, _______________ are passed from parents to offspring
Genes
Genes
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A Summary of Mendel’s Principles
• In cases in which 2 or more forms of a gene are present, some forms of the gene may be _______________________ or ___________________________
• In most sexually reproducing organisms, each adult has two copies of each gene – one from each parent. These genes are segregated from each other when gametes are formed
• The alleles for different genes usually segregate independently of one another
dominantrecessive
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Incomplete Dominance• When one allele is not dominant
over another
• Four o’clock flowers
• The heterozygous phenotype is somewhat in-between the two homozygous phenotypes
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Codominance• When both alleles contribute to
the phenotype of an organism
Ex.) Speckled Chickens
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Multiple Alleles• When more than two possible
alleles exist in a population
Ex.) blood type
• IA
• IB
• i
Dominant
Recessive
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Human Blood TypesPhenotype Genotype
A
B
AB
O
IAIA or IAi
IBIB or IBi
IAIB
ii
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Polygenic Traits• Traits controlled by two or more
genes
Ex.) eye color, skin color
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Genetics and the Environment• The characteristics of any organism,
is not only determined by the genes it inherits
• Characteristics are determined by interactions between genes and the environment
• Ex.) genes may affect a plants height but the same characteristic is influenced by climate, soil conditions and availability of water
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Do Now• Human hair is inherited by
incomplete dominance. Human hair may be curly (CC) or straight (cc). The heterozygous genotype (Cc) produces wavy hair. Show a cross between two parents with wavy hair
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Do Now• A man is suing his wife on grounds of
infidelity. The man claims that the child is blood type O and therefore must be fathered by someone else. Can he use this evidence in court if he and his wife both have heterozygous B genotypes?
• Show the cross of the two parents
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11 – 4 Meiosis
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Objectives• What happens during the events
of meiosis?
• What is the difference between mitosis and meiosis?
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• Gregor Mendel did not know where the genes he had discovered were located in the cell
• Genes are located on ______________________ in the cell ______________
Meiosis
chromosomesnucleus
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Mendel’s principles of genetics require at least 2 things
1. Each organism must inherit… a single copy of every gene from each of its parents
2. When an organism produces its own gametes… these two sets of genes must be separated from each other so that each gamete contains just one set of genes
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Chromosome NumberEx.) fruit fly 8 chromosomes
• 4 from mom, 4 from dad
Ex.) Humans 46 chromosomes
• 23 from mom, 23 from dad
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Homologous• Chromosomes that each have a
corresponding chromosome from the opposite sex parent
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Diploid• A cell that contains both sets
of homologous chromosomes (2N)–Body cells
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Haploid• A cell that contains only a single
set of chromosomes (1N)–Sex cells (gametes)
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Meiosis• A process of reduction division
in which the number of chromosomes per cell is cut in half through the separation of homologous chromosomes in a diploid cell–Makes sex cells
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Meiosis usually involves 2 divisions
• Meiosis I
• Meiosis II
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Meiosis I• prior to meiosis I, each
chromosome is replicated
• The cells then begin to divide similar to mitosis
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Prophase I• Each chromosome pairs with its
corresponding homologous chromosome to form a structure called a _____________________ - has 4 chromatids
Tetrad
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Crossing over• When chromosomes exchange
portions of their chromatids and results in the exchange of alleles
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Crossing over• Leads to new combinations of alleles
• The homologous chromosomes separate, and 2 new cells are formed
• Although each cell now has 4 chromatids something is different. Because each pair of homologous chromosomes was separated, neither of the daughter cells has two complete sets of chromosomes that it would have in a diploid cell
• The two sets have been shuffled
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Meiosis II• The two cells produced by
meiosis I now enter a second meiotic division
• Unlike the 1st division, no chromosomes are replicated
• Each cell’s chromosomes has 2 chromatids
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Metaphase II• 2 chromosomes line up in the
center of each cell
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Anaphase II• The paired chromatids separate
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Telophase II• Forms 4 daughter cells each with
2 chromatids
• These 4 daughter cells are now haploid (N) – just 2 chromosomes each
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Gamete Formation• In male animals, the haploid
gametes produced by meiosis are called sperm
• In some plants they are called pollen
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Spermatogenesis
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Gamete Formation• In females, generally only one of the
cells produced by meiosis is involved in reproduction
• This female gamete is called an egg• The other 3 cells that do not receive
as much cytoplasm as the egg are called polar bodies
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oogenisis
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Comparing Mitosis and Meiosis
• Mitosis results in the production of two genetically identical diploid cells, whereas meiosis produces four genetically different haploid cells
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Comparing Mitosis and Meiosis
46
46 46
46
23 23 23 23
Mitosis Meiosis
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11-5 Linkage and Gene Maps
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Gene Linkage• When genes are located on the
same chromosome they are inherited together (Linkage)
• It’s the chromosomes that assort independently not individual genes
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• When genes are formed on the same chromosome, this does not mean that they are linked forever
• Crossing over during meiosis sometimes separates genes that had been on the same chromosome onto homologous chromosomes
• Cross over events occasionally separate and exchange linked genes and produce new combinations of alleles
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Q: Why is this good?A: Generates genetic diversity
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Gene Maps
• 1911 Alfred Sturtevant
• hypothesized that the further apart genes were, the more likely they were to be separated by a crossover in meiosis
• the rate at which linked genes were separated and recombined could then be used to produce a “map” of distances between genes
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Gene map• Shows the location of each gene