Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9....
Transcript of Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9....
![Page 1: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/1.jpg)
Introduction of SOP’s and Tools for the VL Monitoring and Drug
Resistance Project
Dr Rochelle AdamsAnnual Workshop on Advanced Clinical Care
Elangeni Hotel
30 August 2019
![Page 2: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/2.jpg)
Our new ART Guidelines are Coming
![Page 3: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/3.jpg)
Virologic Management of Patients
So
urc
e: 2
01
9 A
RT
Clin
ica
l Gu
idelin
es
Do a thorough assessment of the cause of an elevated
VL. Consider the possibility of:
A. Adherence problems
B. Bugs (Intercurrent infections)
C. In-Correct ART dosage
D. Drug Interactions
E. REsistance
Routine VL monitoring at 6 months on ART, 12 months on ART, and 12-monthly thereafter
VL > 1000 c/mL
VL > 1000 c/mL
NNRTI-based regimen
(EFV/NVP)
Consider switching to 2ND Lnine if
virological failure confirmed, i.e.
VL > 1000 c/mL on two consecutive
occasions and adherence issues
addressed
InSTI (DTG) or PI-based regimen*
Consider switching to second-line if virological failure
confirmed, i.e. VL > 1000 c/mL on at least three
occasions over the course of two years, or VL >
1000 c/mL with immunological or clinical failure
(i.e. declining CD4 and/or opportunistic infections)
Repeat VL after 3 months
!VL 50-999 c/mLVL < 50 c/mL
Routine VL
monitoring
![Page 4: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/4.jpg)
SOP’s and Tools
• Developed from best practices seen in
eThekwini to:
Provide framework and step by step process for
operationalising the VL Algorithm
Speak to the 2019 guidelines
Be implemented at any level of facility running ART
programs
Be applicable for the management of paediatric and
nonpregnant adolescent and adult patients on ART
![Page 5: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/5.jpg)
Algorithms, Registers, SOP’s, Tools for VL Monitoring and Management
Algorithm
Algorithm for managing
patients with their first VL ≥
50 c/ml
Algorithm for managing non-
pregnant patients on a DTG/PI based regimen for 12
months with two VL ≥ 1000 c/ml
Register
Baseline Chart audit tool
VL Sample log
First High VL register
High VL register for Patients on DTG Or
Protease Inhibitor Based Regimens > 12 Months
With 2 VL ≥1000
Adherence Tools
EAC sessions for paediatric
patients
EAC sessions for adolescent
patients
EAC sessions for adult patients
Baseline EAC Plan
Quality Assurance Tools for
Ongoing Audits
Adult chart review Tool
Paediatric chart review Tool
Roles and Responsibilities of QA team members
VL Champion activities
Standard Operating Procedure for First Line Viral Load Management
Standard Operating Procedure for the Management of high viral load in non-pregnant adolescents
and adults on an INSTI- based or Protease Inhibitor (PI) - based antiretroviral therapy
![Page 6: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/6.jpg)
Algorithms
We have updated the
Algorithms which now speak
to paediatrics and adults
![Page 7: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/7.jpg)
Registers
![Page 8: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/8.jpg)
Enhanced Adherence Counselling Worksheets
Adolescent
Paediatric
Paediatric, Adolescent, Adult Tools
Adult
![Page 9: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/9.jpg)
Quality assurance tools
![Page 10: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/10.jpg)
•It’s a simple statement at the top of the algorithm
•Applicable to all non pregnant ART patients
•But in your facility
•Who makes sure it gets done?
•What do we do to make sure its done?
•When do we do it?
•How do we do it?
Routine VL monitoring at 6 months on ART, 12 months on
ART, and 12-monthly thereafter
![Page 11: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/11.jpg)
Addressing Roles and Responsibilities
![Page 12: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/12.jpg)
The SOP that holds MOST of it together
• Part A:
• Outlines essential
procedures required
to ensure a
successful VL
monitoring
• Part B:
• Management of the
first episode of a VL≥
50 c/mL
• Used in conjunction
with
• Adherence tools
• Algorithm 1
• Register 3
![Page 13: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/13.jpg)
Making VL Monitoring Routine Tools
Register 1: Baseline Chart
audit tool:
• Once off process to verify
clinic ART registry
• Identify active patients and
patient VL status
Register 2: VL sample log
• Catalogues all VL done
• For tracing results (barcode)
• For identifying
unsuppressed VL
![Page 14: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/14.jpg)
![Page 15: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/15.jpg)
![Page 16: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/16.jpg)
Standard Operating Procedure for Managing Non- Pregnant ART Patients With First Viral Load ≥ 50 copies/ml
Algorithm 1
• Outlays routine tasks from
SOP on the right for
making VL Monitoring
routine
• Visit by visit process and
management after 1st
unsuppressed VL
• Use with Register 3 which
tracks patient mx and
outcomes
• Supported by adherence
tools
![Page 17: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/17.jpg)
What to do if 2 VL ≥ 1000 c/mL on DTG or PI?
So our guideline
says this
So we
developed
this
![Page 18: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/18.jpg)
![Page 19: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/19.jpg)
Standard Operating Procedure for Managing Non-Pregnant Patients on a DTG/PI based Regimen for 12 Months & 2 Viral Loads ≥ 1000 copies/ml
Algorithm 2
• Outlays routine tasks from
SOP on the right for
making VL Monitoring
routine
• Visit by visit process and
management after 1st
unsuppressed VL
• Use with Register 4 which
tracks patient
management and
outcomes
![Page 20: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/20.jpg)
Other evidence that they work anywhere!
•Facility in Eastern Cape
•Current TROA +- 1700
•SOP’s and Tools presented 27 March 2019
•Project implemented 01 April 2019
• .
Jan 2019 Feb 2019 March 2019
VL Due 17 22 20
VL done 5 6 3
VL coverage 29.4% 27.3% 15%
VL suppressed 5 6 3
![Page 21: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/21.jpg)
Activities
• Utilizing Base line V/L audit chart, V/L register, FLART register, SLART register.
• VL champion takes 2 hours out of her 8 hours per day dedicated to the project
• Retrieval of VL due patients day before by data capturer
• Reminders attached: Sticker/Lab form
• Files distributed to all consulting rooms in the morning
• Queue marshal directs patients to correct rooms as they
arrive
• Data capturer collects files for VL Champion at the end of
the day
• Chart audits of 118 patients with unsuppressed VL
![Page 22: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/22.jpg)
Results
•Aim:• To improve viral load completion rate from 14% to 90% starting from the 01 April 2019 to the 31 May 2019.
March 19 April 19 May 19 June 2019
VL Due
20 92 150 89
VL done
3 231 283 138
VL coverage
15%
![Page 23: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/23.jpg)
First of last 2 slides!
How do we assess how our patients are being managed and
intervene with targeted interventions?
![Page 24: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/24.jpg)
Quality Assurance Tools for Ongoing Audits
Paediatric & Adult Tools
• 2 Pager
• Reviews initiation visit
• TB screening cascade
• VL monitoring and
management
• Switch from NNRTI to
DTG
• Basic Mx of abnormal
results
• Completion of other
routine care
![Page 25: Introduction of SOP’s and Tools for the VL Monitoring and Drug … of SOP’s and... · 2019. 9. 12. · SOP’s and Tools •Developed from best practices seen in eThekwini to:](https://reader033.fdocuments.in/reader033/viewer/2022060912/60a672aedcce10006d32db0b/html5/thumbnails/25.jpg)
Acknowledgements
The CQUIN Learning Network
25
• Dr Henry Sunpath- Project Co-Ordinator
• CAPRISA ACC Staff
• eThekwini District Management and DOH
Facility staff
• UKZN Department of Infectious Disease
• Maternal and Adolescent Child Health
• REVAMP team
• Epicentre
This project was supported by the Grant or Cooperative Agreement Number U2GGH001142, funded by the Centers for Disease Control and Prevention. Itscontents are solely the responsibility of the presenters and do not necessarilyrepresent the official views of the U.S. Centers for Disease Control and
Prevention or the U.S. Department of Health and Human Services