Introduction

11
Introduction NMR spectroscopy in post- genomic era AC 7121 Spring 2005

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Introduction. NMR spectroscopy in post-genomic era AC 7121 Spring 2005. Nobel for Magnetic Resonance. Isador I. Rabi Nobel Prize in Physics, 1944 For his resonance method for recording the magnetic properties of atomic nuclei. Felix Bloch and Edward M. Purcell , USA - PowerPoint PPT Presentation

Transcript of Introduction

Page 1: Introduction

Introduction

NMR spectroscopy in post-genomic era

AC 7121 Spring 2005

Page 2: Introduction
Page 3: Introduction

Nobel for Magnetic Resonance

Isador I. Rabi

Nobel Prize in Physics, 1944For his resonance method for recording the magnetic properties of atomic nuclei.

Felix Bloch and Edward M. Purcell, USA

Nobel Prize in Physics, 1952

The NMR phenomenon was demonstrated for protons in 1946.

Page 4: Introduction

Richard Ernst, Zurich,

Nobel Prize in Chemistry, 1991For his fundamental contributions to NMR methodology-Nuclear Magnetic Resonance Fourier Transform Spectroscopyhttp://www.nobel.se/chemistry/laureates/1991/ernst-lecture.html

Kurt Wüthrich Nobel Prize in Chemistry, 2002NMR studies of structure and function of biological macromolecules.

. http://www.nobel.se/chemistry/laureates/2002/wuthrich-lecture.html

Nobel for Magnetic Resonance

Page 5: Introduction

Nobel for Magnetic Resonance

Paul C. Lauterbur (Urbana, IL) and Sir Peter Mansfield (Nottingham, UK)Nobel Prize in Physiology or Medicine, 2003For their pioneering contributions which led to the application of magnetic resonance in medical imaging.

                                                  

                           

Page 6: Introduction

Nobel for Magnetic Resonance

Alexeij A. Abrikosow (Argonne, IL) and Vitalij L. Ginzburg (Moscow)

Nobel Prize in Physics, 2003

For pioneering contributions to the theory of type-II superconductors, i.e., those alloys capable of withstanding the high magnetic fields that occur in MR applications.

Page 7: Introduction

1H NMR spectrum of ethanol

•Positions

•Intensities

•Splitting patterns

Page 8: Introduction

Varian A-60 spectrometer(1961) Bruker AV500 spectrometer(1999)

NMR Spectrometer

Page 9: Introduction

From Formula to Structure

C18H21NO3

http://www.acornnmr.com/codeine/1h_chime.htm

Page 10: Introduction

atgggaattg actacgtggt gttttacctc atacccaata tagtgggcgg cttttatatg 61 tttattatgg cgctgggggc ggccaagagg ccgagaagcc acgcctatcc cccgtggag aactacctcg tcgttgtagt tactgtgggc gatgagaggg taatgccggc tttagcggag accgtggccc agctggagag gctggggctg aggtacacag tgctctcctc ccgccccctc cccattaaaa accacatagt agtgccaaaa aagaggacg gctctaaata ccgcgcaatt ctctggttcg ttaagaatta cgccagaaac gacatgtggt atatcttcct tgacgacgac agctacccat tagatacccg atttttacgc gatattgcat attacggagc caggggatgc gtggctggca acggcgtgtt agtgccgagg cccggccgct cagccctcgc atacgcctta gactggatta ggtatttcca cgacttaact cataccgct tttccctcga ggtgctcaga aggcctatat tcggcatgca cggggaattg ttaatagtga ggggggatgt gttgaggagc atctggccgg ctatgggcga caccattacg gaggatttcc gcttcgccat ggagctctta aagcgcaggt acaagacttt tcaaacctcc acaagggtct caattaaaag ccccaactcc ctgagggact tcgtaagaca gagggccagg ggcggcgg tatatcaga ggccgccaag tataaaaacg cctattactt aatcctaacg gcctctccca tcgccctctt cctctcaacc ccggccagct ggctatacgg cttcacaata cccctcttaa tctccgcagt ctacgcctcg gtgtatatat acggtagctt aaaggcgaaa aggtatatat tagacgtgtg gctagcctca tttcttgaat taatgggctt aataatcggc ccgcgagaaaggcgaagaa cttctacgta atagacaaga ggtag

From Sequence to function

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Modern NMR Techniques for Chemistry Research Andrew E. Derome; Pergamon Books Ltd. 1987. (M)

1. 200 and more Basic NMR Experiments a practical Course; S. Braun, H.-O. Kalinowski, S. Berger; Wiley-VCH. (B)

2. Physical Chemistry 4th ed.; Atkins; New York :/Freeman,/c1990. (PC) Chapter 18.

3. Instrumental Analysis 4th ed.; Skoog and Leary; Fort Worth :/Saunders College Pub.(IA) Chapter 14.

4. http://www.cis.rit.edu/htbooks/nmr/

5. http://web.chem.queensu.ca/FACILITIES/NMR/nmr/webcourse

/index.htm

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