INTRANASAL DRUG

DELIVERY TO BRAIN

By K.Bharath ReddyFathima Institute of PharmacyKADAPA.

AN APPROACH TO BYPASS BLOOD BRAIN BARRIER

ABSTRACT As the people have been suffering from many

CNS disorders, like Alzheimers disease, spinal cord injuries, parkinsons disease, brain strokes etc., so many drugs have been developed but they failed in showing the concentration required for action. But this drug delivery is a targeted drug delivery where the drug directly enters into the brain. Fortunately as there is a direct connection to brain via Olfactory lobe which is responsible for olfaction, it is easy to deliver drugs to CNS. This drug delivery does not need modification of drug, no first pass metabolism and there are many advantages with some limitations.

OVERVIEW• DRUG DELIVERY• HOW DOES IT WORK ?• ADVANTAGES• LIMITATIONS• APPLICATIONS• CONCLUSION

Drug delivery

Def: Movement of drug from the site of administration.

If we want to understand drugdelivery in a best a best manner it depends on how best we understand Pharmacokinetics and pharmacodynamics

Pharmacokinetics.-what a body does to drug

Pharmacodynamics.-what a drug does to body

What is BLOOD BRAIN BARRIER ?

Direct contact

Why Intranasal drug delivery ?

HOW DOES IT WORK ?

Lipophillichydrophillic

Different methods of drug administration to CNS

Advanvantages Non invasive, rapid, comfortable.

No modification of drug is needed.

Targetting CNS

Reducing side effects

NO FIRST PASS METABOLISM

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Do we really need Intranasal drug delivery ?

CHALENGE

S

Effective targetting,cost effective.

improved

efficacy.

side effect

s &product life

extention.

Patient

compliance & biologic

al degradation

.

1.Concentration varies

2.Nasal congestion

3.Anosmia

4.Partial degradation

Limitations

Applications 1.Delivery of protein therapeutic agents2.Delivery of DNA plasmids3.Delivery of small molecules4.Drug delivery based organic pharmaceuticals like propranalol,estradiol,Nitroglycerine

Conclusio

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