1

RESULTSHelp inINTERPRETATION

EIS-01-USB System

Electro

InterstitialScan

Electrical Bio Impedance Analysis

Tissue and microcirculation

Manufacturer Specification

developer SOFTMED Technology4rue de la Presse1000-Brussels- Belgium

Medical device Class 2 a

2

RESULTS AND INTERPRETATION

Electro Scan Gram (ESG)

The Electro Scan Gram (ESG) is a graph of the conductivity valuesmeasured in 3 steps by the EIS system

The EIS system uses a software to control coordinate and direct three specific pre-programmed sequences (1 AC amp 2 DC) of brief barely perceptible current pulses throughan array of 6 symmetrically placed surface electrodes left amp right forehead left amp right hands(palms) and left amp right feet (soles)This 6-electrode array forms 22 electrode pairs or ldquovolumesrdquo (see Table 2 on the folderldquobackground of EIS system) The term ldquovolumerdquo refers to the 3-dimensional anatomicalspace that lies between each electrode pair

The conductivity values measuring by EIS system will be displayed in numerical forms on ascale of +100 to ndash 100 for each of the 22 volumes We call this graphic an Electro Scan Gramor ESGInitially the conductivity (C) is in numerical forms on a scale from 0 to +100 (absolutevalues)

These absolute values for conductivity are converted to the +100 to -100 ESG scale by thedetermination of 2 quantities items 0 N and item 0 A

Item 0 N

Item 0 for the measurement N is determined by an empirically-derived coefficient related tothe age height weight and the gender of the subjectItem 0 AItem 0 for the measurement A is determined by the arithmetic average of measurements ofabsolute values

1

2

1

3

Table 1 EIS Procedure Involves 3 Consecutive Pulse Sequences

Measurement 1 The AC pulse sequence occurs first Each of the 6 electrodes pairs(from this point on called ldquovolumesrdquo) receives a 1 second AC pulse of electricity at 5 Hz50 kHz and 200 KHz frequency at le 800 microA current This 1 second AC pulse has 2purposes The first is to determine body composition (BIA) much like the typicalcommercial AC BIM devices The second reason to start with the AC pulse is that it

Step Type of pulsesequence

Duration ofeach pulse

Number ofpulses

localisation Purpose(s)

1 AC 1s 24 Graph 1 in 1Body composition2Improved signal-to-noise ratio in subsequentDC measurement

2 DC 1s 22 Graph 1 inblueGraph 2 inyellow(N1)and in Red(A1)

Interstitial conductivitymeasurement

3 DC 3s 22 Graph 1 inyellowGraph 2 inbraun(N3)and in green(A3)

Interstitial biochemicalanalysis

2

4

has been observed that DC impedance readings have less noise when preceded by anAC pulse32

The 2 sets of DC pulse sequences are identical in tension at 128 V DCHowever the1st DC set sends 1-second duration pulse of electricity through each of the22 volumes of the sequence while the 2nd DC set sends a 3-second duration electricpulseThe DC voltage is measured at each volumersquos cathode is then fed into the PC foranalysis For practical reasons the voltage data is expressed as ldquoconductivityrdquo which isthe inverse of electrical resistance The reason there are 2 DC sets of pulse sequences isto provide the maximum and the minimum conductivity values for each tissue volumeThe 1st DC set generates the maximum conductivity values because a 1-second electricpulse is too brief a time to permit significant electrical current decay to occurMeasurement 2 This 1st DC set is used to determine the interstitial conductivity valuesand the results for the modelingMeasurement 3 In contrast after 3 seconds substantial loss of electrical energy hasoccurred The electrical pulse energy weakens at a rate of 1t where t = time (Cottrellequation or chronoamperometry)This 2nd DC set is used to determine interstitial biochemical values

Reference values

A series of preliminary clinical studies of DC BIM using the EIS device werecarried out in France and Russia several years ago32 During the clinical investigationsthe control groups of healthy subject were tested to generate a normative data base for theEIS results The Figure below illustrates the composite ESG graphic from the normativedatabase

-150

-100

-50

0

50

100

150

4 3 5 7 9 11 13 15 16 19 21

pat1

pat2

pat3

pat4

pat5

pat6

pat7

pat8

pat9

pat10

pat11

pat12

pat13

pat14

5

If you click on the icon RV you can compare the reference values and the ESG patient

ESG of the patient ESG Reference values

This icon determines the Fast Fourier Transformation of ESG graph (55) (56)This transformation is made for simplified the calculations of algorithms and therefore

the interpretation

6

This icon allows visualising the values of all the 22 measurementsIn absolute value (scale 0100)For the AC measurement (AbsAC) the DC 1 second per volume (Abs1) and DC3 seconds per volume (Abs3)

In ESG values (scale 100-100) for the DC 1 second per volume (N1A1) and DC 3 secondsper volume (N3A3)

Help in Interpretation in ESG graph The ESG graph do not require interpretation all thefollowing results are the analysis of the ESG graph The ESG graph was used as a referenceor criteria of judgment of the clinical investigations

7

ModelingModeling ProcessThese images are synthesized images made by a modeling process and derived frommathematical algorithms of both direct and inverse problems For each organ there are 8steps to the process as illustrated below

Modeling

STATISTICA

1

2

3

4

5

6

7

8

8

Chromatology conventions and scale of valuesThe measurement of conductivity on the level of the localized organs makes it possible tocarry out modeling images according to a chromatology corresponding to the measurement ofconductivity

Scale of colours used for conductivities The colour on the left corresponds to a nullconductivity (min=0) The colour on the right has the most significant conductivity for theimage consideredIn all the modeling images one represents the value of conductivity treated according to avalue between - 100+100

In all the modeling imagesRun the cursor over the images at the top of the modeling window you will see the value (inscale +100-100) of the organs corresponding to the conductivity (see chromatology)Right clicking with the mouse on any organ will visualize the corresponding parameterslinked with the conductivity of this organ

Organic EIS Modeling Example

In this modeling example you can see the estimated functions of the Right lobe of the liverfrom a scan recording done by the EIS system

1

2

1

2

9

Heart EIS Modeling Example

2

1

10

Brain EIS Modeling Example

2

1

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

2

RESULTS AND INTERPRETATION

Electro Scan Gram (ESG)

The Electro Scan Gram (ESG) is a graph of the conductivity valuesmeasured in 3 steps by the EIS system

The EIS system uses a software to control coordinate and direct three specific pre-programmed sequences (1 AC amp 2 DC) of brief barely perceptible current pulses throughan array of 6 symmetrically placed surface electrodes left amp right forehead left amp right hands(palms) and left amp right feet (soles)This 6-electrode array forms 22 electrode pairs or ldquovolumesrdquo (see Table 2 on the folderldquobackground of EIS system) The term ldquovolumerdquo refers to the 3-dimensional anatomicalspace that lies between each electrode pair

The conductivity values measuring by EIS system will be displayed in numerical forms on ascale of +100 to ndash 100 for each of the 22 volumes We call this graphic an Electro Scan Gramor ESGInitially the conductivity (C) is in numerical forms on a scale from 0 to +100 (absolutevalues)

These absolute values for conductivity are converted to the +100 to -100 ESG scale by thedetermination of 2 quantities items 0 N and item 0 A

Item 0 N

Item 0 for the measurement N is determined by an empirically-derived coefficient related tothe age height weight and the gender of the subjectItem 0 AItem 0 for the measurement A is determined by the arithmetic average of measurements ofabsolute values

1

2

1

3

Table 1 EIS Procedure Involves 3 Consecutive Pulse Sequences

Measurement 1 The AC pulse sequence occurs first Each of the 6 electrodes pairs(from this point on called ldquovolumesrdquo) receives a 1 second AC pulse of electricity at 5 Hz50 kHz and 200 KHz frequency at le 800 microA current This 1 second AC pulse has 2purposes The first is to determine body composition (BIA) much like the typicalcommercial AC BIM devices The second reason to start with the AC pulse is that it

Step Type of pulsesequence

Duration ofeach pulse

Number ofpulses

localisation Purpose(s)

1 AC 1s 24 Graph 1 in 1Body composition2Improved signal-to-noise ratio in subsequentDC measurement

2 DC 1s 22 Graph 1 inblueGraph 2 inyellow(N1)and in Red(A1)

Interstitial conductivitymeasurement

3 DC 3s 22 Graph 1 inyellowGraph 2 inbraun(N3)and in green(A3)

Interstitial biochemicalanalysis

2

4

has been observed that DC impedance readings have less noise when preceded by anAC pulse32

The 2 sets of DC pulse sequences are identical in tension at 128 V DCHowever the1st DC set sends 1-second duration pulse of electricity through each of the22 volumes of the sequence while the 2nd DC set sends a 3-second duration electricpulseThe DC voltage is measured at each volumersquos cathode is then fed into the PC foranalysis For practical reasons the voltage data is expressed as ldquoconductivityrdquo which isthe inverse of electrical resistance The reason there are 2 DC sets of pulse sequences isto provide the maximum and the minimum conductivity values for each tissue volumeThe 1st DC set generates the maximum conductivity values because a 1-second electricpulse is too brief a time to permit significant electrical current decay to occurMeasurement 2 This 1st DC set is used to determine the interstitial conductivity valuesand the results for the modelingMeasurement 3 In contrast after 3 seconds substantial loss of electrical energy hasoccurred The electrical pulse energy weakens at a rate of 1t where t = time (Cottrellequation or chronoamperometry)This 2nd DC set is used to determine interstitial biochemical values

Reference values

A series of preliminary clinical studies of DC BIM using the EIS device werecarried out in France and Russia several years ago32 During the clinical investigationsthe control groups of healthy subject were tested to generate a normative data base for theEIS results The Figure below illustrates the composite ESG graphic from the normativedatabase

-150

-100

-50

0

50

100

150

4 3 5 7 9 11 13 15 16 19 21

pat1

pat2

pat3

pat4

pat5

pat6

pat7

pat8

pat9

pat10

pat11

pat12

pat13

pat14

5

If you click on the icon RV you can compare the reference values and the ESG patient

ESG of the patient ESG Reference values

This icon determines the Fast Fourier Transformation of ESG graph (55) (56)This transformation is made for simplified the calculations of algorithms and therefore

the interpretation

6

This icon allows visualising the values of all the 22 measurementsIn absolute value (scale 0100)For the AC measurement (AbsAC) the DC 1 second per volume (Abs1) and DC3 seconds per volume (Abs3)

In ESG values (scale 100-100) for the DC 1 second per volume (N1A1) and DC 3 secondsper volume (N3A3)

Help in Interpretation in ESG graph The ESG graph do not require interpretation all thefollowing results are the analysis of the ESG graph The ESG graph was used as a referenceor criteria of judgment of the clinical investigations

7

ModelingModeling ProcessThese images are synthesized images made by a modeling process and derived frommathematical algorithms of both direct and inverse problems For each organ there are 8steps to the process as illustrated below

Modeling

STATISTICA

1

2

3

4

5

6

7

8

8

Chromatology conventions and scale of valuesThe measurement of conductivity on the level of the localized organs makes it possible tocarry out modeling images according to a chromatology corresponding to the measurement ofconductivity

Scale of colours used for conductivities The colour on the left corresponds to a nullconductivity (min=0) The colour on the right has the most significant conductivity for theimage consideredIn all the modeling images one represents the value of conductivity treated according to avalue between - 100+100

In all the modeling imagesRun the cursor over the images at the top of the modeling window you will see the value (inscale +100-100) of the organs corresponding to the conductivity (see chromatology)Right clicking with the mouse on any organ will visualize the corresponding parameterslinked with the conductivity of this organ

Organic EIS Modeling Example

In this modeling example you can see the estimated functions of the Right lobe of the liverfrom a scan recording done by the EIS system

1

2

1

2

9

Heart EIS Modeling Example

2

1

10

Brain EIS Modeling Example

2

1

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

3

Table 1 EIS Procedure Involves 3 Consecutive Pulse Sequences

Measurement 1 The AC pulse sequence occurs first Each of the 6 electrodes pairs(from this point on called ldquovolumesrdquo) receives a 1 second AC pulse of electricity at 5 Hz50 kHz and 200 KHz frequency at le 800 microA current This 1 second AC pulse has 2purposes The first is to determine body composition (BIA) much like the typicalcommercial AC BIM devices The second reason to start with the AC pulse is that it

Step Type of pulsesequence

Duration ofeach pulse

Number ofpulses

localisation Purpose(s)

1 AC 1s 24 Graph 1 in 1Body composition2Improved signal-to-noise ratio in subsequentDC measurement

2 DC 1s 22 Graph 1 inblueGraph 2 inyellow(N1)and in Red(A1)

Interstitial conductivitymeasurement

3 DC 3s 22 Graph 1 inyellowGraph 2 inbraun(N3)and in green(A3)

Interstitial biochemicalanalysis

2

4

has been observed that DC impedance readings have less noise when preceded by anAC pulse32

The 2 sets of DC pulse sequences are identical in tension at 128 V DCHowever the1st DC set sends 1-second duration pulse of electricity through each of the22 volumes of the sequence while the 2nd DC set sends a 3-second duration electricpulseThe DC voltage is measured at each volumersquos cathode is then fed into the PC foranalysis For practical reasons the voltage data is expressed as ldquoconductivityrdquo which isthe inverse of electrical resistance The reason there are 2 DC sets of pulse sequences isto provide the maximum and the minimum conductivity values for each tissue volumeThe 1st DC set generates the maximum conductivity values because a 1-second electricpulse is too brief a time to permit significant electrical current decay to occurMeasurement 2 This 1st DC set is used to determine the interstitial conductivity valuesand the results for the modelingMeasurement 3 In contrast after 3 seconds substantial loss of electrical energy hasoccurred The electrical pulse energy weakens at a rate of 1t where t = time (Cottrellequation or chronoamperometry)This 2nd DC set is used to determine interstitial biochemical values

Reference values

A series of preliminary clinical studies of DC BIM using the EIS device werecarried out in France and Russia several years ago32 During the clinical investigationsthe control groups of healthy subject were tested to generate a normative data base for theEIS results The Figure below illustrates the composite ESG graphic from the normativedatabase

-150

-100

-50

0

50

100

150

4 3 5 7 9 11 13 15 16 19 21

pat1

pat2

pat3

pat4

pat5

pat6

pat7

pat8

pat9

pat10

pat11

pat12

pat13

pat14

5

If you click on the icon RV you can compare the reference values and the ESG patient

ESG of the patient ESG Reference values

This icon determines the Fast Fourier Transformation of ESG graph (55) (56)This transformation is made for simplified the calculations of algorithms and therefore

the interpretation

6

This icon allows visualising the values of all the 22 measurementsIn absolute value (scale 0100)For the AC measurement (AbsAC) the DC 1 second per volume (Abs1) and DC3 seconds per volume (Abs3)

In ESG values (scale 100-100) for the DC 1 second per volume (N1A1) and DC 3 secondsper volume (N3A3)

Help in Interpretation in ESG graph The ESG graph do not require interpretation all thefollowing results are the analysis of the ESG graph The ESG graph was used as a referenceor criteria of judgment of the clinical investigations

7

ModelingModeling ProcessThese images are synthesized images made by a modeling process and derived frommathematical algorithms of both direct and inverse problems For each organ there are 8steps to the process as illustrated below

Modeling

STATISTICA

1

2

3

4

5

6

7

8

8

Chromatology conventions and scale of valuesThe measurement of conductivity on the level of the localized organs makes it possible tocarry out modeling images according to a chromatology corresponding to the measurement ofconductivity

Scale of colours used for conductivities The colour on the left corresponds to a nullconductivity (min=0) The colour on the right has the most significant conductivity for theimage consideredIn all the modeling images one represents the value of conductivity treated according to avalue between - 100+100

In all the modeling imagesRun the cursor over the images at the top of the modeling window you will see the value (inscale +100-100) of the organs corresponding to the conductivity (see chromatology)Right clicking with the mouse on any organ will visualize the corresponding parameterslinked with the conductivity of this organ

Organic EIS Modeling Example

In this modeling example you can see the estimated functions of the Right lobe of the liverfrom a scan recording done by the EIS system

1

2

1

2

9

Heart EIS Modeling Example

2

1

10

Brain EIS Modeling Example

2

1

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

4

has been observed that DC impedance readings have less noise when preceded by anAC pulse32

The 2 sets of DC pulse sequences are identical in tension at 128 V DCHowever the1st DC set sends 1-second duration pulse of electricity through each of the22 volumes of the sequence while the 2nd DC set sends a 3-second duration electricpulseThe DC voltage is measured at each volumersquos cathode is then fed into the PC foranalysis For practical reasons the voltage data is expressed as ldquoconductivityrdquo which isthe inverse of electrical resistance The reason there are 2 DC sets of pulse sequences isto provide the maximum and the minimum conductivity values for each tissue volumeThe 1st DC set generates the maximum conductivity values because a 1-second electricpulse is too brief a time to permit significant electrical current decay to occurMeasurement 2 This 1st DC set is used to determine the interstitial conductivity valuesand the results for the modelingMeasurement 3 In contrast after 3 seconds substantial loss of electrical energy hasoccurred The electrical pulse energy weakens at a rate of 1t where t = time (Cottrellequation or chronoamperometry)This 2nd DC set is used to determine interstitial biochemical values

Reference values

A series of preliminary clinical studies of DC BIM using the EIS device werecarried out in France and Russia several years ago32 During the clinical investigationsthe control groups of healthy subject were tested to generate a normative data base for theEIS results The Figure below illustrates the composite ESG graphic from the normativedatabase

-150

-100

-50

0

50

100

150

4 3 5 7 9 11 13 15 16 19 21

pat1

pat2

pat3

pat4

pat5

pat6

pat7

pat8

pat9

pat10

pat11

pat12

pat13

pat14

5

If you click on the icon RV you can compare the reference values and the ESG patient

ESG of the patient ESG Reference values

This icon determines the Fast Fourier Transformation of ESG graph (55) (56)This transformation is made for simplified the calculations of algorithms and therefore

the interpretation

6

This icon allows visualising the values of all the 22 measurementsIn absolute value (scale 0100)For the AC measurement (AbsAC) the DC 1 second per volume (Abs1) and DC3 seconds per volume (Abs3)

In ESG values (scale 100-100) for the DC 1 second per volume (N1A1) and DC 3 secondsper volume (N3A3)

Help in Interpretation in ESG graph The ESG graph do not require interpretation all thefollowing results are the analysis of the ESG graph The ESG graph was used as a referenceor criteria of judgment of the clinical investigations

7

ModelingModeling ProcessThese images are synthesized images made by a modeling process and derived frommathematical algorithms of both direct and inverse problems For each organ there are 8steps to the process as illustrated below

Modeling

STATISTICA

1

2

3

4

5

6

7

8

8

Chromatology conventions and scale of valuesThe measurement of conductivity on the level of the localized organs makes it possible tocarry out modeling images according to a chromatology corresponding to the measurement ofconductivity

Scale of colours used for conductivities The colour on the left corresponds to a nullconductivity (min=0) The colour on the right has the most significant conductivity for theimage consideredIn all the modeling images one represents the value of conductivity treated according to avalue between - 100+100

In all the modeling imagesRun the cursor over the images at the top of the modeling window you will see the value (inscale +100-100) of the organs corresponding to the conductivity (see chromatology)Right clicking with the mouse on any organ will visualize the corresponding parameterslinked with the conductivity of this organ

Organic EIS Modeling Example

In this modeling example you can see the estimated functions of the Right lobe of the liverfrom a scan recording done by the EIS system

1

2

1

2

9

Heart EIS Modeling Example

2

1

10

Brain EIS Modeling Example

2

1

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

5

If you click on the icon RV you can compare the reference values and the ESG patient

ESG of the patient ESG Reference values

This icon determines the Fast Fourier Transformation of ESG graph (55) (56)This transformation is made for simplified the calculations of algorithms and therefore

the interpretation

6

This icon allows visualising the values of all the 22 measurementsIn absolute value (scale 0100)For the AC measurement (AbsAC) the DC 1 second per volume (Abs1) and DC3 seconds per volume (Abs3)

In ESG values (scale 100-100) for the DC 1 second per volume (N1A1) and DC 3 secondsper volume (N3A3)

Help in Interpretation in ESG graph The ESG graph do not require interpretation all thefollowing results are the analysis of the ESG graph The ESG graph was used as a referenceor criteria of judgment of the clinical investigations

7

ModelingModeling ProcessThese images are synthesized images made by a modeling process and derived frommathematical algorithms of both direct and inverse problems For each organ there are 8steps to the process as illustrated below

Modeling

STATISTICA

1

2

3

4

5

6

7

8

8

Chromatology conventions and scale of valuesThe measurement of conductivity on the level of the localized organs makes it possible tocarry out modeling images according to a chromatology corresponding to the measurement ofconductivity

Scale of colours used for conductivities The colour on the left corresponds to a nullconductivity (min=0) The colour on the right has the most significant conductivity for theimage consideredIn all the modeling images one represents the value of conductivity treated according to avalue between - 100+100

In all the modeling imagesRun the cursor over the images at the top of the modeling window you will see the value (inscale +100-100) of the organs corresponding to the conductivity (see chromatology)Right clicking with the mouse on any organ will visualize the corresponding parameterslinked with the conductivity of this organ

Organic EIS Modeling Example

In this modeling example you can see the estimated functions of the Right lobe of the liverfrom a scan recording done by the EIS system

1

2

1

2

9

Heart EIS Modeling Example

2

1

10

Brain EIS Modeling Example

2

1

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

6

This icon allows visualising the values of all the 22 measurementsIn absolute value (scale 0100)For the AC measurement (AbsAC) the DC 1 second per volume (Abs1) and DC3 seconds per volume (Abs3)

In ESG values (scale 100-100) for the DC 1 second per volume (N1A1) and DC 3 secondsper volume (N3A3)

Help in Interpretation in ESG graph The ESG graph do not require interpretation all thefollowing results are the analysis of the ESG graph The ESG graph was used as a referenceor criteria of judgment of the clinical investigations

7

ModelingModeling ProcessThese images are synthesized images made by a modeling process and derived frommathematical algorithms of both direct and inverse problems For each organ there are 8steps to the process as illustrated below

Modeling

STATISTICA

1

2

3

4

5

6

7

8

8

Chromatology conventions and scale of valuesThe measurement of conductivity on the level of the localized organs makes it possible tocarry out modeling images according to a chromatology corresponding to the measurement ofconductivity

Scale of colours used for conductivities The colour on the left corresponds to a nullconductivity (min=0) The colour on the right has the most significant conductivity for theimage consideredIn all the modeling images one represents the value of conductivity treated according to avalue between - 100+100

In all the modeling imagesRun the cursor over the images at the top of the modeling window you will see the value (inscale +100-100) of the organs corresponding to the conductivity (see chromatology)Right clicking with the mouse on any organ will visualize the corresponding parameterslinked with the conductivity of this organ

Organic EIS Modeling Example

In this modeling example you can see the estimated functions of the Right lobe of the liverfrom a scan recording done by the EIS system

1

2

1

2

9

Heart EIS Modeling Example

2

1

10

Brain EIS Modeling Example

2

1

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

7

ModelingModeling ProcessThese images are synthesized images made by a modeling process and derived frommathematical algorithms of both direct and inverse problems For each organ there are 8steps to the process as illustrated below

Modeling

STATISTICA

1

2

3

4

5

6

7

8

8

Chromatology conventions and scale of valuesThe measurement of conductivity on the level of the localized organs makes it possible tocarry out modeling images according to a chromatology corresponding to the measurement ofconductivity

Scale of colours used for conductivities The colour on the left corresponds to a nullconductivity (min=0) The colour on the right has the most significant conductivity for theimage consideredIn all the modeling images one represents the value of conductivity treated according to avalue between - 100+100

In all the modeling imagesRun the cursor over the images at the top of the modeling window you will see the value (inscale +100-100) of the organs corresponding to the conductivity (see chromatology)Right clicking with the mouse on any organ will visualize the corresponding parameterslinked with the conductivity of this organ

Organic EIS Modeling Example

In this modeling example you can see the estimated functions of the Right lobe of the liverfrom a scan recording done by the EIS system

1

2

1

2

9

Heart EIS Modeling Example

2

1

10

Brain EIS Modeling Example

2

1

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

8

Chromatology conventions and scale of valuesThe measurement of conductivity on the level of the localized organs makes it possible tocarry out modeling images according to a chromatology corresponding to the measurement ofconductivity

Scale of colours used for conductivities The colour on the left corresponds to a nullconductivity (min=0) The colour on the right has the most significant conductivity for theimage consideredIn all the modeling images one represents the value of conductivity treated according to avalue between - 100+100

In all the modeling imagesRun the cursor over the images at the top of the modeling window you will see the value (inscale +100-100) of the organs corresponding to the conductivity (see chromatology)Right clicking with the mouse on any organ will visualize the corresponding parameterslinked with the conductivity of this organ

Organic EIS Modeling Example

In this modeling example you can see the estimated functions of the Right lobe of the liverfrom a scan recording done by the EIS system

1

2

1

2

9

Heart EIS Modeling Example

2

1

10

Brain EIS Modeling Example

2

1

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

9

Heart EIS Modeling Example

2

1

10

Brain EIS Modeling Example

2

1

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

10

Brain EIS Modeling Example

2

1

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

11

Neurovegetative system effects EIS Modeling Example

The modeling of the neurovegetative systemeffects does not visualise the organs butrather the effects of sympathic andparasympathic system on the organs Theseeffects are also estimated in the scale 100-100

Segmental muscular excitability EIS Modeling Example

1

1

2

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

12

Spine EIS Modeling Example

2

1

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

13

The analysis list Icon

Click on this icon and the entire listing of the organs and vertebra will open When you clickon any organ in the listing you will see at the bottom of the listing the Intracellular ph(icpH) the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebraThe whole list and values can be copied and pasted into the doctors conclusionWarning When the analysis list is open direct reading on modeling with the mouse is notpossible

This icon makes it possible to turn the images in all the directions and tozoom in or out on the organs as well as to move the modeling image upor down within the modeling window

This table allows to make adjustment of temperature toaggravating or reduce the chromatology and to visualise theorigin of the dysfunction

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

14

Help in Interpretation in the results of modeling

Interpretation of the different parts of the modelingThe values are

1 In scale 100 -100 The reference values are 20-20 lt -20 and gt -59 in blue

-20 to -30 Mildo Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduced (spine)o Pressure reduced (vessel)o Inhibitor effect (ANS)

-31 to -59 Significant

o Chronic inflammation (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduced (vessel)o Inhibitor effects (ANS)

lt -60 in dark blue Strongo Degenerative process (tissue)o Excitability reduced (brain muscles)o Osseous density reduce (spine)o Pressure reduce (vessel)o Inhibitor effects (ANS)

20 and lt 59 in yellow lt 30 Mild

o acute inflammation (tissue)o Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 31 Significanto acute inflammation (tissue) and painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)o Stimulating effects (ANS)

gt 60 in red Strongo Acute inflammation and possibility of necrosis (tissue) and

painso Excitability increased (brain muscles)o Blocking part in spine (spine)o Pressure increased (vessel)

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

15

2 In physiologic tissue and microcirculation indicated with the norms and units ofmeasurement

You can see all these parameters on the folder ldquospecificationsrdquo table 1 2 and 3 relatedwith the chromatology and the scale 100-100

Brain Modeling1 Frontal lobes are the zone of the thought

o lt -30=gt Depression fatigueo gt 30 =gt Insomnia behaviour disorders

2 The limbic systems are the zone of emotionso lt -30=gt Emotional disorderso gt 30 =gt hyperactivity lack of concentration aggressively

3 The amygdalas are the zone of anguish or phobiao lt -30=gt Anguisho gt 30 =gt Phobia

Unilateral unbalanceo In the right the disorders is recento In the left the disorder is old

Heart Modeling1 Ventricleso lt -30=gt Reduced cardiac pump activityo gt 30 =gt Hypoxia

2 Vesselso lt -30=gt Reduced pressureo gt 30 =gt Increased pressure

3 Coronaryo gt 20 =gt circulatory disorders in the coronary ( atherosclerosis thrombus high blood

viscosity)4 Baroreceptor reflexo gt 20 =gt hypertension

5 Heart rateo gt 85 =gt Tachycardiao lt 60 =gt Bradycardia

Digestive system Modeling1 Colonso lt -30=gt chronic inflammationo gt 30 =gt acute inflammation2 Stomacho lt -30=gt chronic inflammationo gt 30 =gt acute inflammation3 Livero lt -30=gt chronic inflammation side effects of drugso gt 30 =gt acute inflammation increased cholesterol production4 Pancreaso lt -30=gt chronic inflammation and reduced insulin productiono gt 30 =gt acute inflammation increased insulin production and triglycerides

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

16

Urogenital and renal Modeling1 Kidney

o lt -30=gt kidney function reducedo gt 30 =gt interstitial nephropathy

2 Bladdero lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

3 Prostateo lt -30=gt hypertrophy or possibility of degenerative processo gt 30 =gt hypertrophy or acute inflammation

4 Uteruso lt -30=gt chronic inflammation or menstruationo gt 30 =gt acute inflammation or ovulation

Respiratory system Modeling1 Lungs

o lt -30=gt chronic inflammation or hyperventilationo gt 30 =gt acute inflammation or hypoventilation

2 Trachea and Bronchio lt -30=gt chronic inflammationo gt 30 =gt acute inflammation

Thyroid Modelingo lt -30=gt hypo activity see the value of TSH in estimation interstitial hormoneo gt 30 =gt hyperactivity see the value of TSH in estimation interstitial hormone

Thymus Modelingo lt -30=gt Immunity reducedo gt 30 =gt Immunity increased ( auto immune disease possibility)

Spine Modelingo lt -30=gt osseous density reducedo gt 30 =gt pains blocking zones or deformations

Muscular excitability Modelingo lt -30=gt somesthesia disorderso gt 30 =gt pains or lactic acid

The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)and the zones of articular blockage and vertebral dislocation (yellow)The EIS system also modelizes segmental muscular excitability permitting the localization ofpainful muscular zones (yellow) or zones presenting pain of somesthesia (blue)

Neurovegetative or Autonomic Nervous System (ANS) effects Modelingo lt -30=gt Inhibiting effectso gt 30 =gt Stimulating effects

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

17

Statistical functional risk analysisThis graph represents a statistical analysis of the functional risks of the various systems

Functional risk IconRespiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematicalalgorithms of the inverse problems made from all the clinical testing amp investigations Allthese algorithms were integrated into a statistical program (Statistical version 70) Thisprogram is on EIS softwareThe main risk is I the associated risks with II III or IV Click on any of the branches showinga risk and a window will open listing the possibilities of the risk as related to the system

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

18

While you click on the risk the window indicates the possibility of dysfunction or diseaseaccording to specificity and sensitivity statistical calculations and the software automaticallyzooms on the particular system being studied

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

19

Left Click with the mouse to see the vertebra andRight Click on the mouse to see the segmentary muscularexcitability

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

20

This icon

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysisDISCLAIMER According to the results of the tissue parameters microcirculation andinverses problems issues from clinical tests the software propose some possibilities ofdiseases or dysfunction with a specificity and a sensitivity These possibilities are notdiagnostic but help to regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe risk I is not obligatory significant it can be sometimes mild dysfunctionThe risk will be I for the subject even if this risk is minor

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

21

Estimation of the interstitial Oxidative stress free radicalsThese interstitial fluid free radicals of oxidative stress are estimated on scale 0+ 60 withreference norms from 0 to +20 (red lines)The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretationThe oxygen free radicals (H202 and O2-) increased the entropy Selenium will reduce thesefree radicalsThe ONOOH NO and OH- free radicals increased the DNA damages Manganese will reducethese free radicalsThis graphic explains the mechanism of the free radicals production and which substancesare active in their production and prevention

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

22

Estimation of the interstitial cerebral NeurotransmittersThese values are an estimation of interstitial fluid cerebral neurotransmittersThe calculation is made by the chronoamperometry method (Cottrell equation) in a scale -60+60 with reference norms range from -20 to +20 (red lines)The validation of this measurement are made by the clinical tests in St Louis hospital Botkinhospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretationInterstitial cerebral Serotonin

Decreased =gt Depression emotional disordersIncreased=gt Insomnia behaviour disorders

Interstitial cerebral DopamineIncreased =gt addiction hyperactivity lack of concentration aggressivelyDecreased=gt lack of communication lassitude lack of vitality

Interstitial cerebral CatecholaminesIncreased =gt memory disorders stressDecreased=gt lack of concentration lack of vitality fatigue

Interstitial cerebral AcetylcholineIncreased =gt Cranial parasympathetic increased and effects on the cardiac ratefrequency (tachycardia)Decreased=gt Cranial parasympathetic decreased and effects on the cardiac ratefrequency (bradycardia)

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

23

Statistical estimation of some blood biochemical constants valuesThese values are an estimation of blood venous biochemical constants related to thealgorithms issues from clinical study of Marfino center in 2004 (See the full text inwwwldteckcom) in a scale -60+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER According to the results of the tissues parameters microcirculation andinverses problems issues from clinical tests the software propose an statistical estimation ofsome blood biochemical constants with a specificity and a sensitivityThese estimation are not a measurement but help for regulate more specific and sensitivelaboratory tests These estimations are not available for a patient under medications

These values are a screening of blood biochemical constants disorders if the subject is notunder medicationsTriglycerides depend of the fat mass and depend of pancreatic functionUrea depend of the proteins concentration and kidney functionCreatinine depend of muscle and kidney functionGlucose depend of pancreatic function and or cell insulino resistance When the glucoseincrease possibility of microcirculation disorders cardiovascular ocular and renal disordersAtherogenic Index Ratio LDL (bad cholesterol) and HDL cholesterol (goodcholesterol)This index is the more important for estimated the cardiovascular consequence(coronary) than the total cholesterol andor the DHL cholesterol

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

24

Davenport DiagramThese values of Davenport diagram are measured in interstitial fluid with thechronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbachformula for the PCO2Three type or acidosisalkalosis ratios existMetabolic depends of the level of the bicarbonates Norms SBE=0 Ligns of bicarbonates inblue (Bic) if the bicarbonates increased (SBE positive) the result is metabolic alkalosis if thebicarbonates decreased (SBE negative) the result is metabolic acidosis

Respiratory Norms PCO2= 46 if the PCO2 decreased (on the left) the result is respiratoryalkalosis if the PCO2 decreased (on the right) the result is respiratory acidosis

Interstitial Fluid Norm=733

This icon allows to access to the 22 divisions of the Diagram

Typical Zones

Acute Respiratory Acidosis (7 amp 8)Chronic Respiratory Acidosis (5)Metabolic Alkalosis (3)Acute Respiratory Alkalosis (18 amp 19)Chronic Respiratory Alkalosis (16)Metabolic Acidosis (14)

1

2

3

2

3

1

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

25

Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50years ago Originally this diagram was made with the data from arterial bloodIt was used in hospital for arterial blood gases results and for the patient under anaesthesiaThe value of arterial blood gases analysis is the diagnosis of renal failure or respiratoryinsufficientlyTherefore in the medical office this examination is very rarely utilizedBecause there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells andvery low protein concentrations) the acid base balance depends predominently upon the cellsactivity (mitochondria ATP production) Useage of the interstitial values in the DavenportDiagram will allow relatively early detection of dysfunctions disorders or diseases andgreatly changes the benefits of using this Diagram

Our patient databases from clinical trials were examined with the interstitial DavenportDiagram with the following resultsPatients not undergoing under any drugs

1 On the left of the diagram respiratory acidosis Cardiovascular disorders or diseases Diabetes II Renal disorder Hyperthyroidism Inflammation or germs infections

2 On the right down metabolic acidosis Cancers Renal failure Diabetes I

3 On the right of the diagram Respiratory alkalosis Hypothyroidism

These results are not available for making a diagnosis because they havevery high specificity but not low sensibility

The benefits of the Davenport Diagram is the therapeutic follow up (see thefolder clinical applications)

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

26

Interstitial IonogramsThese values are measured in interstitial fluid with the chronoamperometry method (Cottrellequation) (See clinical tests 2004 MARFINO in wwwldteckcom)

Help in interpretation in interstitial ionogramsThe blood ionogram (sample in capillary) is rarely regulated in medical office the mainindication will be the renal disordersThe reason will be the extreme variability of the results if there is not renal failure or deepmetabolic acidosis or alkalosis (patients in hospital)The interstitial fluid ionogram

1 Is more stable because this compartment is stagnant2 Is not under the dependence of the dilution (intra and extra cellular) which can change

completely the true results for example the hyponatremia of dilutionSo the results of interstitial ionograms should be different from blood ionogram (in particularthe natremia) and are complementaryInterstitial values interpretationPhosphatesIncrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHypomagnesaemia Diarrhoea Tetania Cutaneous affectionsDecrease Hyperparathyroidism Bone affections Osteolysis Hypervitaminose DPotassiumDecrease Possibility of Hyper insulinaemia Hyperthyroidism Interstitial nephropathy

Hypercorticism associed with hypertension (Hyperaldosteronism)Increase Possibility of Hypocorticoadrenal hypoaldosteronism Diabetes keto acidosisHypoinsulinism Muscular troubles Fibrillation conduction troublesDrugs linked with hyper kaliaemia Diuretic B-blockers Inhibitor of Angiotensinogenicenzyme Antibiotics Corticoids Glucose insulin or potassium perfusionCalciumDecrease Possibility of Hypoparathyroidism Hypovitaminose D PancreatitisHyperphosphataemia Hypomagnesaemia Diarrhoea TetaniaLower ventricular contraction Cutaneous affections

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

27

Increase Hyperparathyroidism Bone affections Osteolysis Constipation NauseasHypervitaminose DMagnesiumDecrease Possibility of Intestinal malabsorption Diarrhoeas HyperaldosteronismHyperthyroid Hypoparathyroidism PancreatitisIncrease Possibility of Renal failure Blood volume decreased HypothyroidHyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine SodiumDecrease Possibility of Extra cellular dehydratationIncreased lipidaemia Increased triglycerides Increased glycaemia Water retention EdemaIncrease Possibility of Hyperventilation HyperaldosteronismIronDecrease AnaemiaIncrease Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessmentThese values are an estimation of interstitial fluid hormonal assessment related to the valuesof endocrine organs in the modeling with a scale -60+60 with reference norms range from-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessmentThe interstitial fluid and the blood hormonal assessment are completely different exceptfor the TSH measurement (See clinical test Botkin hospital 2006)The estimation of interstitial fluid hormonal assessment

1 Is more stable because this compartment is stagnant2 Is the true target of the hormones the bloodstream is only a way for the distribution of

the hormones into the tissueInterpretation of the results requires some physiology knowledge in particular thechronobiology and the peak of production of the different hormonesCortisolWith inflammation The production of cortisol is increased The production of cortisolreduces the ACTH production (feedback effect) and DHEA balance in cortico adrenalproduction)

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

28

Without inflammation The peak is the morning (wake up) decrease until 11am then increaseuntil 4pm and then decreaseThyroid HormonesThe production of the thyroid is increased if the body temperature is too high andor if youneed to increase your metabolism (stress effort sport)The production of thyroid hormone reduces the TSH production (feedback effect)At normal body temperature condition and without stress or effortThe peak will be at 11am then decrease or stable related your activityCatecholaminesIncrease with stress and the production is related to your activity and lifestyleReduced catecholamine are related to the symptom of fatigueSexual hormonesFor women related to their menstruation cycleThe production of oestradiol reduces the FSH production (biofeedback effect)For the men the level of testosterone is related to the brain activity Good news increases thelevel of testosterone and bad news depression inflammation reduces the level of testosteroneInsulinIncreases with food intake in particular carbonic hydrate and sugarsDecreases if you do not eatThe level of aldosterone is increased in metabolic acidosisThe level of ADH is increased if there is dehydratationThe level of PTH hormone is related to the calcemia levels

Body Composition estimationThe calculation of the body composition is made according to the Bioelectrical ImpedanceAnalysis (BIA) (62) (63)The BIA analysis uses a range of frequencies between 5Hz and 200 KHz

Help in interpretation in the body compositionThe BMI is not sufficient for estimations of overweight The body composition is necessary tounderstand and follow up a treatment regimeThe body composition is significant for the follow up of sports (fat mass and muscular mass) diabetes (water retention fat mass) and obesity (fat mass water retention)The intracellular and extra cellular water disorders are necessary for follow up the water andsodium disorders (water retention or dehydratation) and in the follow up of diabetescardiovascular diseases and cancers

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

29

Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable andmodifiable tables before impression

Supplementary examinations

Depending on the results of the statistical functional risk a list of supplementaryexaminations is proposed for the risk I and II

Conventional examinations Laboratory tests

The health care professional will choose the final prescription within the clinical context

Diet and micro-nutrition

Warning These recommended or not recommended foods are temporary (4- 6 weeks) theywill be revised to the next examinationThese foods are recommended or not recommended according to an analysis program issuefrom the acid-base balance the main functional risk the BMI and the body compositionWarning The micro nutrition is indicating in particularly vulnerable people such as themalnourished alcoholics cancer sufferers and pregnant women This list of micro nutrimentsis a suggestion of some products according to the analysis of tissue parameters statistical riskanalysis Body composition and BMI the health care professional will choose the finalprescription within the clinical context

Diets are proposed in the form of foods which are recommended or not recommended Micro-nutrition Cooking methods Regime Food associations Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

30

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

31

References Table of acidalkaline foods

Table 19A

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

32

Table 19B

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

33

Table 19C

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

34

Therapeutic follow up

To open this window you must select 2 visits click twice on the last visit then once on thevisit that you wish compared and visit 2 The 2 visits will be shown in the window on thebottom right side of the screen

Modeling and physiological tissue and microcirculation parameters of the organs comparisonexample

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

35

Button 1 ESG graphs comparison example (scale 0100 and 100-100)

Button 2 Free radicals comparison example (oxidative stress)

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

36

Button 3 Ionogram and hormones comparison example

Button 4 Biochemistry values and davenport diagram comparison example

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

37

Button 5 Hormonal Follow up comparison example (for all the visits of the patient)This process will be taking some minutes please wait

Button 6 Acid base balance and body composition comparison example (follow up for allthe visits of the patient)

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

38

Button 7 Acid base balance and body composition follow up for all the visits of the patient

Button 8 Statistical functional risks comparison example (follow up for all the visits of thepatient)

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

39

Time necessary for follow-up treatment visualization

Functional or alternative medicine

Auricular acupuncture somatic acupuncture homeopathy biofeedback

5 minutes

Chiropractic

Immediately following the treatment

Nutrition micro nutrition Plant therapy micro nutrition trace elements nutrition

6 weeks

Allopathic treatments

Antibiotics 3 days Hypotensive therapies 3 weeks Antiagregants 3 weeks Anticoagulant 24 hours Diuretics 3 weeks Antidepressants IRSS 45 days Surgery 24 hours Chemotherapy 1 week

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

40

SummaryA synthesis of the measurements taken in editorial form Estimation of interstitial biochemical values Statistical Main functional Risk Statistical Associated functional Risk General metabolic functions

Physicianrsquo notesYou can find this icon in all the windows of the software You can utilize this window withthe functions cut copy or paste or write your commentary When you click OK thisinformation will be automatically reported in the summary and in the status report for printing

Summary

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

41

Auricular acupuncture ElectroAuriculoGram (EAG)Warning According to new conventions the ElectroAuriculoGram (EAG) displays on theearrsquos points the values of the modeling The ear illustrations provided are courtesy of DrTerry Oleson(USA) The list of points (results analysis points points related to the symptomsand tabagism) is a suggestion according to the analysis of tissue and blood parametersstatistical functional risk analysis and brain analysis The health care professional will choosethe points within the clinical context

Icon Help to choose the points according to the selected symptoms

Icon Help to choose the points in the tabagism treatment

Icon Help to choose the points according to the program analysis

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

42

Somatic Acupuncture

Measurements are displayed in graphic form and are classified in several groupsIn the analysis list Chinese names for the meridians have been retained to specify that theyare bioelectrical points and reflexogenic circuits and not the degree by which the organcorresponding to the meridian is affected While you click on the list you get the resistancevalue of each meridian

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridiansCan be affected unilaterally

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

43

Tendinous muscular meridiansA meridian must be affected bilaterally (right and left)

LO points

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

44

Therapeutic decision aid in choosing somatic acupuncture pointsWarning This list of somatic acupuncturersquos points is a suggestion according to the analysisof the meridian measurements the health care professional will choose the points within theclinical context

HomeopathyThe design was produced by Dr Richard Clement(MD FranceUSA)Warning This list of homeopathic products is a suggestion according to the analysis of tissueand blood parameters statistical risk analysis Body composition and BMI and brain analysisThe health care professional will choose the final prescription within the clinical context

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

45

Bio feedback Program (BFP)The biofeedback program sends alternatively AC with intensity 650microA and frequenciesbetween 1000 Hz and 50 KHz on the 22 volumes of ESGThe biofeedback program provides a regulation of the neurovegetative system (sympatheticand parasympathetic systems) and acts on the stress which affects various volumes of thebodyAccording to the value of each volume the program stimulates or reduces the stress (inversionof polarity)Indication of Use of Biofeedback ProgramThe indications of use the Biofeedback Program depend of the understanding and theconsequence of the stressDefinition of the stress

In medical terms stress is the disruption of homeostasis through physical or psychologicalstimuli Stressful stimuli can be mental physiological anatomical or physical reactions Theterm stress in this context was coined by Austro-Canadian endocrinologist Hans Selye whodefined the General Adaptation Syndrome or GAS paradigm in 1936

General Adaption Syndrome ( 69) (70)

This is a model on stress researched mainly by Hans Selye[3][4] on rats and other animals Hisresearch involved exposing animals to unpleasant or harmful stimuli such as injectionsextreme cold and even vivisection

He found that all animals showed a very similar series of reactions broken into three stagesHe describes this universal response to the stressors as the General Adaption Syndrome orGAS in 1936

Stage one alarm

When the threat or stressor is identified or realized the bodys stress response is a state ofalarm During this stage adrenaline will be produced in order to bring about the fight or flightresponse There is also some activation of the HPA axis producing cortisol

Stage two resistance

If the stressor persists it becomes necessary to attempt some means of coping with the stressAlthough the body begins to try to adapt to the strains or demands of the environment thebody cannot keep this up indefinitely so its resources are gradually depleted

Stage three exhaustion

In the final stage in the GAS model all the bodys resources are eventually depleted and thebody is unable to maintain normal function At this point the initial autonomic nervous systemsymptoms may reappear (sweating raised heart rate etc) If stage three is extended long termdamage may result as the capacity of glands especially the adrenal gland and the immunesystem is exhausted and function is impaired resulting in decompensation The result canmanifest itself in obvious illnesses such as ulcers depression or even cardiovascular problemsalong with other mental issues

46

Neuro-chemistry and Physiology

The neurochemistry of the general adaptation syndrome is now believed to be well understoodalthough much remains to be discovered about how this system interacts with others in thebrain and elsewhere in the body

The body reacts to stress first by releasing the catecholamine hormones epinephrine andnorepinephrine and the glucocorticoid hormones cortisol and cortisone

The hypothalamic-pituitary-adrenal axis (HPA) is a major part of the neuroendocrine systeminvolving the interactions of the hypothalamus the pituitary gland and the adrenal glandsThe HPA axis is believed to play a primary role in the bodys reactions to stress by balancinghormone releases from the adrenaline-producing adrenal medulla and from the corticosteroid-producing adrenal cortex Stress can significantly affect many of the bodys immune systemsas can an individuals perceptions of and reactions to stress The termpsychoneuroimmunology is used to describe the interactions between the mental statenervous and immune systems as well as research on the interconnections of these systems

Actions of cortisol and the catecholamine (68)

Sugars Metabolism increase in the production of sugars by the liver hyperglycaemia andhyperinsulinism (diabetes)Proteins Metabolism increase in the protidic destruction (muscles skin bone)Fat mass Metabolism inhibit the lipogenesis raises cholesterol and triglyceridesWater Calcium and Sodium Metabolism increase the drainage of water by the kidney theretention of salt and the calcium and potassium loss in the urinesBone tissue metabolism and growth inhibition of Growth by action on the cartilageantagonism with the vitamin D and probable inhibition of the growth hormone The stop ofthe growth in the child can occur for amounts relatively lowAction on coagulation increase the risk of thrombosisAction in Brain Euphoria action stimulative on the central nervous system and increase therisk of insomniaBloodstream Action Hypertensive action and hypoxemiaImmunological Action action anti-inflammatory and anti-allergic agent

In excess cortisol Increase the risk of infections

Digestive Action increase the gastric acidity being able to involve an ulcer and decrease thecolon peristaltic actionOxidative stress action Increase the free radicals of oxygenCommon factors of stress

Both negative and positive stressors can lead to stress Some common categories andexamples of stressors include

Sensory pain bright light Life events birth and deaths marriage and divorce Responsibilities lack of money unemployment Workstudy exams project deadlines Personal relationships conflict deception

47

Lifestyle heavy drinking insufficient sleep Early life exposure (eg child abuse) can permanently alter an individuals stress

response Environmental Lack of control over environmental circumstances such as food

housing health freedom or mobility

One evaluation of the different stresses in peoples lives is the Holmes and Rahe stress scale

Chronic stress

Chronic stress is stress that lasts a long time or occurs frequently Chronic stress is potentiallydamaging Family problems a difficult class at school a schedule that is too busy or a longillness can cause chronic stress

Symptoms of chronic stress are

eating problems upset stomach headache backache insomnia anxiety depression or anger

There are many ways to control chronic stress including exercise proper diet timemanagement adequate rest and relaxing hobbies

Oxidative stress

Oxidative stress is caused by an imbalance between the production of reactive oxygen and abiological systems ability to readily detoxify the reactive intermediates or easily repair theresulting damage All forms of life maintain a reducing environment within their cells Thecellular redox environment is preserved by enzymes that maintain the reduced state through aconstant input of metabolic energy Disturbances in this normal redox state can cause toxiceffects through the production of peroxides and free radicals that damage all components ofthe cell including proteins lipids and DNA

In humans oxidative stress is involved in many diseases such as atherosclerosis Parkinsonsdisease and Alzheimers disease and it may also be important in ageing However reactiveoxygen species can be beneficial as they are used by the immune system as a way to attackand kill pathogens and as a form of cell signaling

Protocol of use of the biofeedback program1 To take a dynamic examination2 To register a new visit the patient is in contact with the electrodes face hands and feet toclick on icon BFEThe system sends a variable frequency (between 1000 Hz and 50 KHz) positive or negative(polarity) according to the value of volume and alternatively on 22 volumes into positive ornegative according to the value of volume in the following sequence5 6 7 8 19 20 21 22 11 12 2 4 15 17 1 3 16 18 9 10The process lasts approximately 3 minutes

3 To Click twice on visit BFE and then on the icon ldquoControl measurementrdquo in order tonote the biofeedback effects

48

4 If the effects are overall positive to remake the process 2 times both 6 minutes and

stop the process

Interpretation and help of the results of alternative medicineAuricular and somatic punctureThe EIS system provides the possibility of the visualization of your puncture (permanent in

auricular or laser or electro stimulation) in use of the measurement FCM and follow up

For this control the time will be 5 minutes

Biofeedback programSame possibility of visualization after 3 minutes of sending frequency and or 9 minutes

Same process using of the measurement FCM and follow up

For this control the time will be 5 minutes

HomeopathySame possibility of visualization after taking the treatment ( not on the skin)

Same process using of the measurement FCM and follow up

For this control the time will be 5 minutes

Reliability and stability of the resultsThe results are functional and the reliability is closer to the results of the laboratory tests

EIS system value of reference was determined from clinical investigations

The analytical variation reflects the inaccuracy of the method used one estimates this by

analyzing the test several times

For EIS system the follow up of a subject without treatment during 1 year was made for

more 100 cases with physiological more modification that the follow up of laboratory tests

The intra-individual variation is estimated by the repetition of the examination to the same

individual The clinical investigations at the Botkin hospital made it possible successively to

record the patients 3 times No notable modification

An experiment of Dr Richard Clement was carried out by recording 2 patients on 2 different

computers of mark and in 2 different geographical places No notable modification

The inter-individual variation estimates by the average values of several individuals and is

influenced by variables such as age and gender

The EIS system takes in to account age gender weight and height in the scale measurement

by applying a mathematical formula with a specific coefficient

This calibration is carried out automatically by the software after recording of the patientrsquos

data

Its specificity and its sensitivity (See the results of clinical investigations in

wwwsoftmedtechnologycom)

49

Factors of variationThe conductivity (and the results of physiologic tissue parameters) can be modified by thefactors of this table 16 and must be included for results interpretation Some of these factorsare contraindications for the calculation of body composition

Decrease in conductivity Increase in conductivity Variable factorstemperature of the part lt15deg C

temperature of the part gt 25deg C Contraceptive pill

Tranquilizing Radiotherapy over 20 cigarettes per dayAntidepressant Surgery Seasonal rhythmsBarbiturates Chemotherapy Weekly rhythmsDiuretics CarbonicAnhydrase

Substitute hormonal treatmentpost or menopausic

Circadian rhythms

HBP Medications Hormonal treatment Biological rhythmsStatin Drugs Coffee and caffeine RaceAnticoagulant Puberty PostureAntibioticAnti histamine

Living at high altitude Noise

Morning Intense physical activity 8hours before theexamination

Pregnancy as from the 5thmonth

Exposure to the light Strong alcohol or drugs orstimulants (amphetamines) 12hours before the examination

Metal in the body (pins apartfrom the dental prostheses)

Menopause Fever and infections Immobilization lyingSpa Treatment Vomiting MenstruationFast Lactation

Strict vegetarian Acid food or high contributionprotein

Recent emotional shock

Diarrhoea ObesityHypolipemiants Hemorrhages of all kinds

50

General principles of Interpretation of the resultsLimits of decisionThe interpretation of an EIS scan must not be based only upon a comparison between the

result(s) and the reference values provided by the scan Interpretation also requires a

definition of physiological limits On the other hand physiological limits of decision

fluctuate according to the objectives

Established diagnosis

Follow-up of the patient

Diseases considered

Possible therapies

Prevalence

So it is impossible to make the interpretation of the EIS system without theclinical context

Just like laboratory tests the interpretation of the EIS requires that the user has medical

knowledge of adequate references and a list of variables which can modify the results (See

table 17)

The following specific issues need to be understood and respected if one is to properly

interpret the results of an EIS scan

1 The results obtained by the EIS system should not be used imperatively to confirm nor

deny laboratory tests the results of imagery devices or an electrical activity recording device

Each medical examination or evaluation has its own specificities and results on the same

organ can be different according to the technique used (see table 8 amp 9) EIS scanning brings

new elements of a complementary nature such as physiologic tissue and micro circulation

parameters (see table2) as well as the biochemical values of the interstitial fluid (See table 6)

2 Biochemical values EIS and Laboratory tests further comments

Table 1 shows the differences in concentration of the biochemical values for each

compartment

All the values of interstitial fluid are different from the laboratory testsThere are specifics of this compartment and the interpretation of the results are not thesame that the results of blood or urinary tests These results are complementary(See clinical test in Marfino center 2005 wwwsoftmedtechnologycom)

The pH values are different (ie than arterial blood) because interstitial fluid does not have

the main blood buffering elements (such as Haemoglobin and proteins) The acid base balance

of interstitial fluid is regulated by the cellsrsquo activity and the electrolytic balance between the

extra and intracellular medium

The biochemical values are calculated in interstitial fluid Unlike the bloodstream this

compartment is stagnant

3 The modeling is a representation of the organs as well as the physiopathology of interstitial

fluid which traverses them The physiopathology of interstitial fluid will be a direct reflection

of the cellular activity of these organs EIS does not give information about the physical

structure of organs

51

4 According to the results of the tissues parameters microcirculation and inverses problemsissues from clinical tests the software propose some statistical possibilities of diseases ordysfunction with a specificity and a sensitivity These possibilities are not diagnostic butscreening or help for regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe strong point of the EIS system is the follow up and the early visualization of the effects ofany therapy

5 All data about a cellrsquos blood nerves vessels lymphatic muscles and articulations arecomputed by extrapolation

6 The EIS device provides a lot of results but for the interpretation of cases you do not needall the data The EIS device is a modeling of the human body and perhaps my point will bebetter understood if we make a comparison with another type of modeling the GPS (GlobalPositioning Service)

GPS is a modeling allowing one to find the specific directions about how to get to a specificdestination To use a GPS you must first input both the departure address and the destinationaddress For the EIS system the interpretation requires the same information the departureaddress is the clinical context (check up known pathology symptoms any treatment inprogress antecedents etc) the destination address is the goal you wish to achieve for theclient and what parameters you need to check in relation to the departure address (clinicalcontext)

52

Manufacturer Specification developer

SOFTMED Technology

REF DRampI Version 9 01092007

• RESULTS AND INTERPRETATION
• Electro Scan Gram (ESG)
• Table1EIS Procedure Involves 3 Consecutive Pulse Sequences
• Reference values
• Fast fourie Transformation (FFT)
• Values
• Help in interpretation ESG
• Modeling
• Modeling Process
• Chromatology conventions and scale of values
• Organic EIS Modeling Example
• Heart EIS Modeling Example
• Brain EIS Modeling Example
• Neurovegetative system effects EIS Modeling Example
• Segmental muscular excitability EIS Modeling Example
• Spine EIS Modeling Example
• options icons
• Help in Interpretation in the results of modeling
• Statistical functional risk analysis
• Help in interpretation for the statistical risk analysis
• Estimation of the interstitial Oxidative stressfree radicals
• Help in interpretation
• Estimation of the interstitial cerebral Neurotransmitters
• Help in interpretation
• Statistical estimation of some blood biochemical constants values
• Help in interpretation
• Davenport Diagram
• Help in interpretation of the Davenport Diagram
• Interstitial Ionograms
• Help in interpretation in interstitial ionograms
• Help in interpretation in interstitia lionograms
• Estimation of interstitial Hormonal assessment
• Help in interpretation in estimation of interstitial hormonal assessment
• Body Composition estimation
• Help in interpretation in the body composition
• Supplementary examinations
• Diet and micro nutrition
• References tables acidalkaline foods
• Therapeutic follow up
• Time necessary for follow-up treatment visualization
• Summary
• Physician notes
• Auricular acupuncture
• Somatic acupuncture
• Homeopathy
• Bio feedback Program (BFP)
• Protocol of use of the biofeedback program
• Interpretation and help of the results of alternative medicine
• Reliability and stability of the results
• Factors of variation
• General principles of Interpretation of the results

50

General principles of Interpretation of the resultsLimits of decisionThe interpretation of an EIS scan must not be based only upon a comparison between the

result(s) and the reference values provided by the scan Interpretation also requires a

definition of physiological limits On the other hand physiological limits of decision

fluctuate according to the objectives

Established diagnosis

Follow-up of the patient

Diseases considered

Possible therapies

Prevalence

So it is impossible to make the interpretation of the EIS system without theclinical context

Just like laboratory tests the interpretation of the EIS requires that the user has medical

knowledge of adequate references and a list of variables which can modify the results (See

table 17)

The following specific issues need to be understood and respected if one is to properly

interpret the results of an EIS scan

1 The results obtained by the EIS system should not be used imperatively to confirm nor

deny laboratory tests the results of imagery devices or an electrical activity recording device

Each medical examination or evaluation has its own specificities and results on the same

organ can be different according to the technique used (see table 8 amp 9) EIS scanning brings

new elements of a complementary nature such as physiologic tissue and micro circulation

parameters (see table2) as well as the biochemical values of the interstitial fluid (See table 6)

2 Biochemical values EIS and Laboratory tests further comments

Table 1 shows the differences in concentration of the biochemical values for each

compartment

All the values of interstitial fluid are different from the laboratory testsThere are specifics of this compartment and the interpretation of the results are not thesame that the results of blood or urinary tests These results are complementary(See clinical test in Marfino center 2005 wwwsoftmedtechnologycom)

The pH values are different (ie than arterial blood) because interstitial fluid does not have

the main blood buffering elements (such as Haemoglobin and proteins) The acid base balance

of interstitial fluid is regulated by the cellsrsquo activity and the electrolytic balance between the

extra and intracellular medium

The biochemical values are calculated in interstitial fluid Unlike the bloodstream this

compartment is stagnant

3 The modeling is a representation of the organs as well as the physiopathology of interstitial

fluid which traverses them The physiopathology of interstitial fluid will be a direct reflection

of the cellular activity of these organs EIS does not give information about the physical

structure of organs

51

4 According to the results of the tissues parameters microcirculation and inverses problemsissues from clinical tests the software propose some statistical possibilities of diseases ordysfunction with a specificity and a sensitivity These possibilities are not diagnostic butscreening or help for regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe strong point of the EIS system is the follow up and the early visualization of the effects ofany therapy

5 All data about a cellrsquos blood nerves vessels lymphatic muscles and articulations arecomputed by extrapolation

6 The EIS device provides a lot of results but for the interpretation of cases you do not needall the data The EIS device is a modeling of the human body and perhaps my point will bebetter understood if we make a comparison with another type of modeling the GPS (GlobalPositioning Service)

GPS is a modeling allowing one to find the specific directions about how to get to a specificdestination To use a GPS you must first input both the departure address and the destinationaddress For the EIS system the interpretation requires the same information the departureaddress is the clinical context (check up known pathology symptoms any treatment inprogress antecedents etc) the destination address is the goal you wish to achieve for theclient and what parameters you need to check in relation to the departure address (clinicalcontext)

52

Manufacturer Specification developer

SOFTMED Technology

REF DRampI Version 9 01092007

• RESULTS AND INTERPRETATION
• Electro Scan Gram (ESG)
• Table1EIS Procedure Involves 3 Consecutive Pulse Sequences
• Reference values
• Fast fourie Transformation (FFT)
• Values
• Help in interpretation ESG
• Modeling
• Modeling Process
• Chromatology conventions and scale of values
• Organic EIS Modeling Example
• Heart EIS Modeling Example
• Brain EIS Modeling Example
• Neurovegetative system effects EIS Modeling Example
• Segmental muscular excitability EIS Modeling Example
• Spine EIS Modeling Example
• options icons
• Help in Interpretation in the results of modeling
• Statistical functional risk analysis
• Help in interpretation for the statistical risk analysis
• Estimation of the interstitial Oxidative stressfree radicals
• Help in interpretation
• Estimation of the interstitial cerebral Neurotransmitters
• Help in interpretation
• Statistical estimation of some blood biochemical constants values
• Help in interpretation
• Davenport Diagram
• Help in interpretation of the Davenport Diagram
• Interstitial Ionograms
• Help in interpretation in interstitial ionograms
• Help in interpretation in interstitia lionograms
• Estimation of interstitial Hormonal assessment
• Help in interpretation in estimation of interstitial hormonal assessment
• Body Composition estimation
• Help in interpretation in the body composition
• Supplementary examinations
• Diet and micro nutrition
• References tables acidalkaline foods
• Therapeutic follow up
• Time necessary for follow-up treatment visualization
• Summary
• Physician notes
• Auricular acupuncture
• Somatic acupuncture
• Homeopathy
• Bio feedback Program (BFP)
• Protocol of use of the biofeedback program
• Interpretation and help of the results of alternative medicine
• Reliability and stability of the results
• Factors of variation
• General principles of Interpretation of the results

51

4 According to the results of the tissues parameters microcirculation and inverses problemsissues from clinical tests the software propose some statistical possibilities of diseases ordysfunction with a specificity and a sensitivity These possibilities are not diagnostic butscreening or help for regulate more specific and sensitive supplementary examinationsThese possibilities are not available for a patient under medications (drugs or chemotherapyradiotherapy surgery) In this case the statistical functional risk analysis is a follow up ofeffects of these therapiesThe strong point of the EIS system is the follow up and the early visualization of the effects ofany therapy

5 All data about a cellrsquos blood nerves vessels lymphatic muscles and articulations arecomputed by extrapolation

6 The EIS device provides a lot of results but for the interpretation of cases you do not needall the data The EIS device is a modeling of the human body and perhaps my point will bebetter understood if we make a comparison with another type of modeling the GPS (GlobalPositioning Service)

GPS is a modeling allowing one to find the specific directions about how to get to a specificdestination To use a GPS you must first input both the departure address and the destinationaddress For the EIS system the interpretation requires the same information the departureaddress is the clinical context (check up known pathology symptoms any treatment inprogress antecedents etc) the destination address is the goal you wish to achieve for theclient and what parameters you need to check in relation to the departure address (clinicalcontext)

52

Manufacturer Specification developer

SOFTMED Technology

REF DRampI Version 9 01092007

• RESULTS AND INTERPRETATION
• Electro Scan Gram (ESG)
• Table1EIS Procedure Involves 3 Consecutive Pulse Sequences
• Reference values
• Fast fourie Transformation (FFT)
• Values
• Help in interpretation ESG
• Modeling
• Modeling Process
• Chromatology conventions and scale of values
• Organic EIS Modeling Example
• Heart EIS Modeling Example
• Brain EIS Modeling Example
• Neurovegetative system effects EIS Modeling Example
• Segmental muscular excitability EIS Modeling Example
• Spine EIS Modeling Example
• options icons
• Help in Interpretation in the results of modeling
• Statistical functional risk analysis
• Help in interpretation for the statistical risk analysis
• Estimation of the interstitial Oxidative stressfree radicals
• Help in interpretation
• Estimation of the interstitial cerebral Neurotransmitters
• Help in interpretation
• Statistical estimation of some blood biochemical constants values
• Help in interpretation
• Davenport Diagram
• Help in interpretation of the Davenport Diagram
• Interstitial Ionograms
• Help in interpretation in interstitial ionograms
• Help in interpretation in interstitia lionograms
• Estimation of interstitial Hormonal assessment
• Help in interpretation in estimation of interstitial hormonal assessment
• Body Composition estimation
• Help in interpretation in the body composition
• Supplementary examinations
• Diet and micro nutrition
• References tables acidalkaline foods
• Therapeutic follow up
• Time necessary for follow-up treatment visualization
• Summary
• Physician notes
• Auricular acupuncture
• Somatic acupuncture
• Homeopathy
• Bio feedback Program (BFP)
• Protocol of use of the biofeedback program
• Interpretation and help of the results of alternative medicine
• Reliability and stability of the results
• Factors of variation
• General principles of Interpretation of the results

52

Manufacturer Specification developer

SOFTMED Technology

REF DRampI Version 9 01092007

• RESULTS AND INTERPRETATION
• Electro Scan Gram (ESG)
• Table1EIS Procedure Involves 3 Consecutive Pulse Sequences
• Reference values
• Fast fourie Transformation (FFT)
• Values
• Help in interpretation ESG
• Modeling
• Modeling Process
• Chromatology conventions and scale of values
• Organic EIS Modeling Example
• Heart EIS Modeling Example
• Brain EIS Modeling Example
• Neurovegetative system effects EIS Modeling Example
• Segmental muscular excitability EIS Modeling Example
• Spine EIS Modeling Example
• options icons
• Help in Interpretation in the results of modeling
• Statistical functional risk analysis
• Help in interpretation for the statistical risk analysis
• Estimation of the interstitial Oxidative stressfree radicals
• Help in interpretation
• Estimation of the interstitial cerebral Neurotransmitters
• Help in interpretation
• Statistical estimation of some blood biochemical constants values
• Help in interpretation
• Davenport Diagram
• Help in interpretation of the Davenport Diagram
• Interstitial Ionograms
• Help in interpretation in interstitial ionograms
• Help in interpretation in interstitia lionograms
• Estimation of interstitial Hormonal assessment
• Help in interpretation in estimation of interstitial hormonal assessment
• Body Composition estimation
• Help in interpretation in the body composition
• Supplementary examinations
• Diet and micro nutrition
• References tables acidalkaline foods
• Therapeutic follow up
• Time necessary for follow-up treatment visualization
• Summary
• Physician notes
• Auricular acupuncture
• Somatic acupuncture
• Homeopathy
• Bio feedback Program (BFP)
• Protocol of use of the biofeedback program
• Interpretation and help of the results of alternative medicine
• Reliability and stability of the results
• Factors of variation
• General principles of Interpretation of the results