International Regulome Consortium Toronto – October 29, 2005 Cindy Bell, VP, National Genomics...
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International Regulome Consortium
Toronto – October 29, 2005Cindy Bell, VP, National Genomics ProgramGenome Canada
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Genome Canada – Organizational Structure
Genome Centres
Board of Directors
Science and Industry Advisory Committee
Prairie
Ontario
Québec
Atlantic
B.C.
Genome Canada(President & CEO)
Functional Genomics GenotypingSequencingProteomics
Bioinformatics Automation
GELS
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Funding and Investments
GenomeCanadalaunch
2000 2001 2002 2003 2004 2005 2006
Comp Iprojectsbegin
Comp IIprojectsbegin
AppliedHealthprojectsbegin
Comp IIIprojectsbegin
Comp I &Comp IIprojectsend
FederalBudget2000$160 M
FederalBudget2001$140 M
FederalBudget2003$75 M
FederalBudget2004$60 M
FederalBudget2005$165 M
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Genome Canada = $600 millionPartner Funding = $600 millionTotal Funding = $1,200 million
Sectors
Genome Canada Portfolio
(September 2005)
B.C. Prairie Ontario Quebec Atlantic Total
Agriculture 2 4 1 1 8
Bioinformatics 1 1
Environment 1 2 1 4
Fisheries 2 2 4
Forestry 2 1 2 1 6
GE3LS 2 2 3 2 9
Health 18 4 20 20 3 65
Technology
Development
2 3 5
Platforms 5 1 2 1 1 10
Total Projects 32 13 33 26 8 112
50 Genome Canada-funded projects are expected to end by March 31, 2006.
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Why International?
Leverage core StrengthsComplementary ScienceFacilitiesResourcesFunding
Visibility / Branding Recruitment Emerging Opportunities
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National Genomics StrategyInternational Partners
Sweden
U.K.Denmark
Spain Norway
GenomeCanada
GenomeQuebec
GenomeAtlantic
GenomeOntario
GenomeB.C.
Nether-lands
Estonia
GenomePrairie
USA
Australia
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International Projects – Mechanisms for Support
• Investigator Initiated (regular application to Genome Canada with an international
partner)
• Bilateral Competition (e.g., Genome Canada/Geñoma Espana)
• Community Led (e.g., Bovine project)
• International Consortium Initiative (e.g., SGC)
September 2005
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USA 30 %
UK 25 %
Japan 25 %
China 10%
Canada 10 %The HapMap will describe patterns of DNA sequence variation. It will be a key resource to find genes and responses to drugs.
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TitleHigh Throughput Mammalian Functional Analysis for the Discovery of Novel Determinants of Human Disease
Goals The International Knock-out Mouse Project is a worldwide effort to generate knock-out mutations in every gene in the mouse genome
Budget (CDN$) $23.6 million (maximum approved budget)
PartnersAffiliated with the European Conditional Mouse Mutagenesis Project
Project LeadersGeoff Hicks, University of ManitobaJanet Rossant, Mount Sinai Hospital
North AmericanConditional MouseMutagenesis Project
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Project Locations Canada Spain
Flatfish Genomics
(Halibut & Sole)
IMB, Halifax
IRTA, Barcelona
$ 2.0 M $ 3.0 M
Grapevine Genomics
(Wine & Table grapes)
UBC, Vancouver
CSI, Madrid
$ 3.1 M $ 3.1 M
Neurodevelopment Disorders University of Toronto
CRG, Barcelona
$ 2.6 M $ 2.6 M
TOTALS $ 7.7 M $8.7 M
Genome CanadaGenoma España
Joint Projects
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Total Budget $53 million US
Funding Partners NIH’s NHGRI $25 million
USDA 11 million
State of Texas 10 million
Genome Canada 5 million
Australia & New Zealand 2 million
Sequencing Efforts
Genomic DNA sequencing – Baylor College of Medicine
Gene sequencing – Genome BC platform at BC Cancer Agency & U. of Alberta
Bovine GenomeSequencing Project
(Bos taurus)
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International Consortium Initiative
• Designed for unique international projects with potential for significant impact on Canadian science
• Project must be led by a Canadian researcher and request a minimum of $50 million over 3 years
• Genome Canada will pay up to 25% of total costs
• Workshop funds available to help develop consortia
• One proposal and five workshops have been approved to date
September 2005
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Goals
Determine the three-dimensional structure of more than 350 human proteins
Encourage the development of new and improved drugs
Location Univ. of Toronto (lead) and Univ. of Oxford
CEO Aled Edwards, University of Toronto
Funding
(CAN$ over 3 yrs)
Wellcome Trust $46 MNordic Node $15 MGenome Canada $15 MORDCF $15 MOIT $ 7 MGlaxoSmithKlein $ 6 MCIHR $ 6 M TOTAL= $110 M
FeaturesLargest health research project funded in CanadaProtein structures will be in public domain
Canada-UK Structural Genomics Consortium
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Canada
Finland, Sweden, Norway, Denmark, Netherlands, UK
Estonia
United Kingdom
Vision: Foster international harmonization for public projects in population genomics
Public Population Project in Genomics
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150 rue Metcalfe Street, Suite 2100Ottawa, OntarioCANADA K2P 1P1Tel: (613)751-4460Fax: (613)751-4474
www.genomecanada.ca