Interlink between Metabolic pathways

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Dr. Vijay Marakala, MBBS, MD.

Senior LecturerBIOCHEMISTRY

IMS, MSU.

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Metabolism

Sum of all the chemical transformations taking place in a cell or organism, occurs through a

series of enzyme-catalyzed reactions that constitute

metabolic pathways.

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METABOLIC PATHWAY

O Each step in the pathway is catalyzed by a SPECIFIC ENZYME frequently aided by ancillary substances called COENZYMES and COFACTORS

A series of LINKED REACTIONS

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TYPES OF METABOLIC PATHWAYS

O Catabolic (degradation) pathways

O Anabolic (biosynthesis) pathways

O Amphibolic pathways

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STAGES OR PHASES OF

METABOLISM

O Digestion in the gastrointestinal tract

O Absorbed , catabolized to smaller components, and ultimately oxidized to CO2

O Reducing equivalents releasing energy through ETC

PRIMARY

SECONDARY OR INTERMEDIARY AND

TERTIARY METABOLISM

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Precursor Intermediates Product

METABOLIC PATHWAY

Metabolites

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CARBOHYDRATES

PROVISION OF ENERGY

LIPIDS

PROVISION OF ENERGY

PROTEINS

BODY BUILDING PURPOSE

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THE THREE STAGES OF

METABOLISM

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THE THREE STAGES OF

METABOLISM

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Intermediary metabolism

Combined activities of all the metabolic pathways

that interconvert precursors, metabolites,

and products

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CatabolismAnabolism

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If there is excess in energy - converted to building

blocks of proteins, carbohydrates and lipids

CatabolismAnabolism

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THANK YOU