INTERACTION OF NANO-PARITCLES WITH THE LUNG Peter Gehr Institute for Anatomy, University of Bern
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INTERACTION OF NANO-PARITCLES WITH THE LUNG Peter Gehr Institute for Anatomy, University of Bern 38th Joint Meeting Special Session on Nanoparticles Paris OECD Headquarters 7th June, 2005
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INTERACTION OF NANO-PARITCLES WITH THE LUNG Peter Gehr Institute for Anatomy, University of Bern. 38th Joint Meeting Special Session on Nanoparticles Paris OECD Headquarters 7th June, 2005. S. Tschanz. Macrophages in vitro : Laser Scanning Microscopy. without particles. [% of cells]. - PowerPoint PPT Presentation
Transcript of INTERACTION OF NANO-PARITCLES WITH THE LUNG Peter Gehr Institute for Anatomy, University of Bern
INTERACTION OF NANO-PARITCLES WITH THE LUNG
Peter GehrInstitute for Anatomy, University of Bern
38th Joint Meeting Special Session on Nanoparticles
Paris OECD Headquarters7th June, 2005
S. Tschanz
1-mpolystyreneparticles
F-Actin
control + cytochalasin D
78-nmpolystyreneparticles
Macrophages in vitro: Laser Scanning Microscopy
0
20
40
60
80
100
120
1 2
100
0
50
[% of cells] without particles
with particles
control + cyt. D
0.2-mpolystyreneparticles
control + cyt. D0
10
20
30
40
50
60
70
80
90
100
1 2
without particles
with particles100
0
50
[% of cells]
control + cyt. D
without particles
with particles100
0
50
[% of cells]
B. Rothen-Rutishauser, published in Geiser et al., 2005. Environ Health Perspect: doi:10.1289/ehp.8006.
Autofluo-rescence
1-m particles 0.2-m particles
78-nm particles 20-nm particles0.2-m
B. Rothen-Rutishauser, published in Geiser et al., 2005. Environ Health Perspect: doi:10.1289/ehp.8006.
Red Blood Cells in vivo: Analytical Transmission Electron Microscopy
Titanium Dioxide, ~30 nm
Energy Loss [eV]450 550
34
40
coun
ts [
x104 ]
500 nm
N. Kapp
E.R. WeibelN. Kapp
Geiser et al., 2005. Environ Health Perspect: doi:10.1289/ehp.8006.
Acknowledgements
Bern, Institute of Anatomy:
Barbara Rothen-RutishauserMarianne GeiserStephen Kiama GitahiNadine KappBarbara KupferschmidSandra Frank
Barbara TschirrenBeat Haenni
Bern, University Hospital:
Vinzenz Im Hof
University of Calgary:
Samuel Schürch
GSF-Neuherberg/Munich,Institute for Inhalation Biology:
Joachim HeyderWolfgang KreylingHolger Schulz
Supported by the Swiss National Science Foundation, the Silva Casa Foundation and the Swiss Agency for the Environment, Forests and Landscape (SAEFL/BUWAL)
